Project

PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

Navigation
Downloads

Results for nfe2l1b+nfe2l2b

Z-value: 1.06

Motif logo

Transcription factors associated with nfe2l1b+nfe2l2b

Gene Symbol Gene ID Gene Info
ENSDARG00000076533 nuclear factor, erythroid 2-like 1b
ENSDARG00000089697 nuclear factor, erythroid 2-like 2b
ENSDARG00000114820 nuclear factor, erythroid 2-like 1b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nfe2l1bdr11_v1_chr12_+_28854410_28854410-0.795.3e-21Click!
nfe2l2bdr11_v1_chr6_-_10902916_109029160.084.5e-01Click!

Activity profile of nfe2l1b+nfe2l2b motif

Sorted Z-values of nfe2l1b+nfe2l2b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_38750871 19.20 ENSDART00000114238
ENSDART00000052325
ENSDART00000137001
coagulation factor II (thrombin)
chr5_-_63509581 15.04 ENSDART00000097325
complement component 5
chr14_+_21107032 13.68 ENSDART00000138319
ENSDART00000139103
ENSDART00000184735
aldolase b, fructose-bisphosphate
chr22_+_38229321 13.61 ENSDART00000132670
ENSDART00000104504
si:ch211-284e20.8
chr11_+_37216668 12.24 ENSDART00000173076
zgc:112265
chr2_+_1486822 10.22 ENSDART00000132500
complement component 8, alpha polypeptide
chr16_+_26777473 9.67 ENSDART00000188870
cadherin 17, LI cadherin (liver-intestine)
chr12_+_6041575 9.19 ENSDART00000091868
glucose-6-phosphatase a, catalytic subunit, tandem duplicate 2
chr2_-_38035235 9.06 ENSDART00000075904
cerebellin 5
chr7_+_25036188 8.90 ENSDART00000163957
ENSDART00000169749
sb:cb1058
chr20_+_25581627 8.59 ENSDART00000030229
cytochrome P450, family 2, subfamily P, polypeptide 9
chr20_-_25518488 8.36 ENSDART00000186993
cytochrome P450, family 2, subfamily N, polypeptide 13
chr8_-_10932206 7.77 ENSDART00000124313
nuclear receptor subfamily 1, group H, member 5
chr1_+_26411496 7.66 ENSDART00000112263
Rho guanine nucleotide exchange factor (GEF) 38
chr20_-_30370884 7.57 ENSDART00000062429
allantoicase
chr7_-_26270014 7.54 ENSDART00000079347
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chr10_+_28428222 7.42 ENSDART00000135003
si:ch211-222e20.4
chr4_+_5249494 7.02 ENSDART00000150391
si:ch211-214j24.14
chr7_+_33172066 6.82 ENSDART00000174013
si:ch211-194p6.12
chr2_-_6039757 6.79 ENSDART00000013079
sterol carrier protein 2a
chr6_-_49526510 6.66 ENSDART00000128025
ribosomal protein S26, like
chr15_-_1745408 6.17 ENSDART00000182311
syntaxin 1A (brain)
chr8_+_554531 6.03 ENSDART00000193623

chr3_-_32541033 6.00 ENSDART00000151476
ENSDART00000055324
reticulocalbin 3, EF-hand calcium binding domain
chr2_+_37207461 5.88 ENSDART00000138952
ENSDART00000132856
ENSDART00000137272
ENSDART00000143468
apolipoprotein Da, duplicate 2
chr5_+_57924611 5.80 ENSDART00000050949
B-cell translocation gene 4
chr8_+_24745041 5.71 ENSDART00000148872
solute carrier family 16, member 4
chr23_+_26017227 5.44 ENSDART00000002939
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr17_-_45104750 5.30 ENSDART00000075520
aldehyde dehydrogenase 6 family, member A1
chr25_+_37443194 5.11 ENSDART00000163178
ENSDART00000190262
solute carrier family 10, member 3
chr13_-_4223955 5.10 ENSDART00000113060
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
chr11_+_30306606 5.04 ENSDART00000128276
ENSDART00000190222
UDP glucuronosyltransferase 1 family, polypeptide B4
chr8_-_2506327 5.03 ENSDART00000101125
ENSDART00000125124
ribosomal protein L6
chr2_+_11031360 4.91 ENSDART00000180020
ENSDART00000145093
acyl-CoA thioesterase 11a
chr18_-_46010 4.85 ENSDART00000052641
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr21_-_5881344 4.82 ENSDART00000009241
ribosomal protein L35
chr21_+_1647990 4.81 ENSDART00000148540
ferrochelatase
chr6_+_13201358 4.80 ENSDART00000190290

chr23_+_39695827 4.78 ENSDART00000113893
ENSDART00000186679
transmembrane and coiled-coil domains 4
chr6_-_23931442 4.62 ENSDART00000160547
SEC16 homolog B, endoplasmic reticulum export factor
chr16_-_22192006 4.59 ENSDART00000163338
interleukin 6 receptor
chr11_+_30310170 4.40 ENSDART00000127797
UDP glucuronosyltransferase 1 family, polypeptide B3
chr23_-_270847 4.39 ENSDART00000191867
ankyrin repeat and sterile alpha motif domain containing 1Aa
chr14_-_970853 4.36 ENSDART00000130801
acyl-CoA synthetase long chain family member 1b
chr1_-_33645967 4.29 ENSDART00000192758
claudin g
chr16_-_25606235 4.27 ENSDART00000192741
zgc:110410
chr13_+_33688474 4.23 ENSDART00000161465

chr10_-_1961576 4.21 ENSDART00000042441
teratocarcinoma-derived growth factor 1
chr6_+_60112200 4.21 ENSDART00000008243
PRELI domain containing 3
chr7_+_49654588 4.14 ENSDART00000025451
ENSDART00000141934
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7b
chr18_+_808911 4.09 ENSDART00000172518
cytochrome c oxidase subunit Vab
chr3_+_33300522 4.09 ENSDART00000114023
heat shock protein, alpha-crystallin-related, 9
chr2_+_26647472 4.05 ENSDART00000145415
ENSDART00000157409
tocopherol (alpha) transfer protein
chr2_-_24398324 4.01 ENSDART00000165226
zgc:154006
chr4_-_17805128 3.96 ENSDART00000128988
Spi-2 proto-oncogene
chr17_+_27456804 3.96 ENSDART00000017756
ENSDART00000181461
ENSDART00000180178
cathepsin L.1
chr23_+_4890693 3.93 ENSDART00000023537
troponin C type 1a (slow)
chr1_+_47486104 3.89 ENSDART00000114746
leucine rich repeat containing 58a
chr22_+_3156386 3.87 ENSDART00000161212
ribosomal protein L36
chr3_+_58092212 3.78 ENSDART00000156059
si:ch211-256e16.7
chr5_-_20123002 3.77 ENSDART00000026516
peroxisomal membrane protein 2
chr24_-_27452488 3.76 ENSDART00000136433
chemokine (C-C motif) ligand 34b, duplicate 8
chr16_+_30604387 3.75 ENSDART00000058785
family with sequence similarity 210, member Ab
chr6_-_10835849 3.75 ENSDART00000005903
ENSDART00000135065
ATP synthase membrane subunit c locus 3b
chr6_-_52675630 3.72 ENSDART00000083830
syndecan 4
chr19_-_10330778 3.69 ENSDART00000081465
ENSDART00000136653
ENSDART00000171232
coiled-coil domain containing 106b
chr11_+_11974708 3.68 ENSDART00000125060
zgc:64002
chr9_+_426392 3.63 ENSDART00000172515
basic leucine zipper and W2 domains 1b
chr17_-_51938663 3.62 ENSDART00000179784
ergosterol biosynthesis 28 homolog
chr18_+_44673990 3.61 ENSDART00000018625
N-ethylmaleimide-sensitive factor attachment protein, alpha b
chr17_+_24006792 3.59 ENSDART00000122415
si:ch211-63b16.4
chr8_+_28467893 3.57 ENSDART00000189724
solute carrier family 52 (riboflavin transporter), member 3
chr1_-_59104145 3.57 ENSDART00000132495
ENSDART00000152457
si:zfos-2330d3.1
si:zfos-2330d3.7
chr21_+_17768174 3.50 ENSDART00000141380
retinoid X receptor, alpha a
chr22_-_36774219 3.50 ENSDART00000056151
ENSDART00000168711
aminoacylase 1
chr12_+_48841419 3.48 ENSDART00000125331
discs, large homolog 5b (Drosophila), tandem duplicate 1
chr25_-_13050959 3.46 ENSDART00000169041
chemokine (C-C motif) ligand 35, duplicate 1
chr9_+_23770666 3.45 ENSDART00000182493
si:ch211-219a4.3
chr15_-_34418525 3.44 ENSDART00000147582
alkylglycerol monooxygenase
chr9_-_23152092 3.43 ENSDART00000180155
ENSDART00000186935
LY6/PLAUR domain containing 6B
chr13_+_16279890 3.37 ENSDART00000101775
ENSDART00000057948
annexin A11a
chr23_+_44049509 3.37 ENSDART00000102003
TXK tyrosine kinase
chr1_-_52494122 3.35 ENSDART00000131407
aspartoacylase (aminocyclase) 3, tandem duplicate 2
chr24_-_10006158 3.32 ENSDART00000106244
zgc:171750
chr22_-_17677947 3.30 ENSDART00000139911
tight junction protein 3
chr10_-_40448736 3.29 ENSDART00000137644
ENSDART00000168190
trace amine associated receptor 20p
chr3_-_7656059 3.26 ENSDART00000170917
JunB proto-oncogene, AP-1 transcription factor subunit b
chr7_-_45990681 3.25 ENSDART00000165441
si:ch211-260e23.7
chr2_-_24069331 3.24 ENSDART00000156972
ENSDART00000181691
ENSDART00000157041
solute carrier family 12 (potassium/chloride transporter), member 7a
chr24_-_39186185 3.20 ENSDART00000123019
ENSDART00000191114
nucleotide binding protein 2 (MinD homolog, E. coli)
chr1_-_45320126 3.20 ENSDART00000133572
si:ch73-90k17.1
chr1_-_53880639 3.19 ENSDART00000010543
LTV1 ribosome biogenesis factor
chr24_-_26485098 3.14 ENSDART00000135496
ENSDART00000009609
ENSDART00000133782
ENSDART00000141029
ENSDART00000113739
eukaryotic translation initiation factor 5A
chr21_-_20840714 3.13 ENSDART00000144861
ENSDART00000139430
complement component 6
chr20_-_13765749 3.06 ENSDART00000133529
opsin 8, group member c
chr11_-_270210 3.05 ENSDART00000005217
ENSDART00000172779
aminolevulinate, delta-, synthase 1
chr7_-_73815262 3.04 ENSDART00000185351
zgc:165555
chr9_-_42861080 3.03 ENSDART00000193688
titin, tandem duplicate 1
chr14_-_14659023 3.02 ENSDART00000170355
ENSDART00000159888
ENSDART00000172241
NAD(P) dependent steroid dehydrogenase-like
chr10_+_39248911 3.01 ENSDART00000170079
ENSDART00000167974
FAD-dependent oxidoreductase domain containing 1
chr4_+_77948517 2.99 ENSDART00000149305
protein kinase C and casein kinase substrate in neurons 2
chr20_-_43459761 2.96 ENSDART00000137422
Pim proto-oncogene, serine/threonine kinase, related 133
chr17_+_24684778 2.95 ENSDART00000146309
ENSDART00000082237
zinc finger protein 593
chr7_+_24574824 2.90 ENSDART00000189871
si:dkeyp-75h12.7
chr3_-_34078179 2.89 ENSDART00000191687
immunoglobulin heavy variable 6-2
chr4_+_18824959 2.86 ENSDART00000146141
ENSDART00000040424
solute carrier family 26 (anion exchanger), member 3
chr25_+_469855 2.85 ENSDART00000104717
ribosomal L24 domain containing 1
chr7_+_49695904 2.84 ENSDART00000183550
ENSDART00000126991
achaete-scute family bHLH transcription factor 1b
chr5_-_33274943 2.83 ENSDART00000143435
ENSDART00000145222
ENSDART00000004797
kynurenine aminotransferase 1
chr22_+_19289970 2.82 ENSDART00000137976
ENSDART00000132386
si:dkey-21e2.15
chr18_-_43866001 2.82 ENSDART00000150218
trehalase (brush-border membrane glycoprotein)
chr3_+_59411956 2.80 ENSDART00000166982
SEC14-like lipid binding 1
chr12_+_16281312 2.79 ENSDART00000152500
protein phosphatase 1, regulatory subunit 3Cb
chr2_-_30734098 2.78 ENSDART00000133769
retinitis pigmentosa 1 (autosomal dominant)
chr3_-_34107685 2.78 ENSDART00000151130
immunoglobulin heavy variable 4-3
chr14_-_9281232 2.76 ENSDART00000054693
ankyrin repeat and SOCS box-containing 12b
chr15_+_46853252 2.72 ENSDART00000186040
zgc:153039
chr25_-_28926330 2.72 ENSDART00000155173
electron transfer flavoprotein beta subunit lysine methyltransferase
chr16_+_21426524 2.71 ENSDART00000182869
gasdermin Eb
chr25_-_35139520 2.70 ENSDART00000189008

chr25_+_29472361 2.69 ENSDART00000154857
interleukin 17 receptor E-like
chr20_-_43079478 2.69 ENSDART00000060982
sorting nexin 9b
chr13_-_38039871 2.69 ENSDART00000140645

chr6_+_42475730 2.68 ENSDART00000150226
macrophage stimulating 1 receptor a
chr15_+_5973909 2.67 ENSDART00000126886
ENSDART00000189618
immunoglobulin superfamily, member 5b
chr24_-_25098719 2.67 ENSDART00000193651
pleckstrin homology-like domain, family B, member 2b
chr21_-_45086170 2.67 ENSDART00000188963
Rap guanine nucleotide exchange factor (GEF) 6
chr3_+_3810919 2.67 ENSDART00000056035

chr8_-_32385989 2.67 ENSDART00000143716
ENSDART00000098850
lipase, endothelial
chr19_+_15441022 2.65 ENSDART00000098970
ENSDART00000140276
lin-28 homolog A (C. elegans)
chr18_+_33276609 2.62 ENSDART00000137208
vomeronasal 2 receptor, x3
chr20_-_38746889 2.60 ENSDART00000140275
tripartite motif containing 54
chr15_+_36187434 2.59 ENSDART00000181536
ENSDART00000099501
ENSDART00000154432
mannan-binding lectin serine peptidase 1
chr12_+_4900981 2.58 ENSDART00000171507
CD79b molecule, immunoglobulin-associated beta
chr25_+_15939275 2.57 ENSDART00000126641
PTPRF interacting protein, binding protein 2b (liprin beta 2)
chr4_+_25220674 2.56 ENSDART00000066934
inter-alpha-trypsin inhibitor heavy chain family, member 5
chr7_-_21925863 2.55 ENSDART00000191213
si:dkey-85k7.10
chr25_+_36347126 2.54 ENSDART00000152449
si:ch211-113a14.22
chr24_+_21346796 2.54 ENSDART00000126519
shisa family member 2b
chr11_+_41936435 2.52 ENSDART00000173103
aldehyde dehydrogenase 4 family, member A1
chr25_-_16554757 2.51 ENSDART00000154480
si:ch211-266k8.6
chr16_-_29557338 2.50 ENSDART00000058888
HORMA domain containing 1
chr16_+_50163352 2.50 ENSDART00000153890
ENSDART00000060522
si:ch211-231m23.4
chr15_-_12270857 2.49 ENSDART00000170093
si:dkey-36i7.3
chr10_-_40352250 2.49 ENSDART00000150821
trace amine associated receptor 20f
chr24_+_38301080 2.49 ENSDART00000105672
myosin binding protein C, fast type b
chr4_+_30785713 2.45 ENSDART00000165945
si:dkey-178j11.5
chr7_+_49681040 2.43 ENSDART00000176372
ENSDART00000192172
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7b
chr1_+_57145072 2.43 ENSDART00000152776
si:ch73-94k4.4
chr3_-_39171968 2.41 ENSDART00000154494
si:dkeyp-57f11.2
chr25_+_35134393 2.40 ENSDART00000185379

chr7_+_6969909 2.39 ENSDART00000189886
actinin alpha 3b
chr11_+_6009984 2.38 ENSDART00000185680
GTP binding protein 3, mitochondrial
chr17_-_43031763 2.36 ENSDART00000132754
ENSDART00000050399
Niemann-Pick disease, type C2
chr20_+_10727022 2.36 ENSDART00000104185
si:ch211-182e10.4
chr7_-_11020900 2.36 ENSDART00000182976

chr14_+_16036139 2.35 ENSDART00000190733
PRELI domain containing 1a
chr7_-_5029478 2.35 ENSDART00000193819
leukotriene B4 receptor
chr8_+_42718135 2.32 ENSDART00000158900
zgc:194007
chr24_-_38192003 2.32 ENSDART00000109975
C-reactive protein 7
chr16_+_43077909 2.32 ENSDART00000014140
RUN domain containing 3b
chr1_+_53221858 2.31 ENSDART00000191877

chr1_+_56886214 2.30 ENSDART00000152718
ENSDART00000182408
si:ch211-1f22.8
chr5_-_9073433 2.30 ENSDART00000099891
ATP synthase membrane subunit eb
chr3_+_3545825 2.30 ENSDART00000109060

chr9_+_23714406 2.28 ENSDART00000189445
glycophorin C (Gerbich blood group)
chr9_+_54984537 2.27 ENSDART00000029528
motile sperm domain containing 2
chr22_+_28337429 2.26 ENSDART00000166177
interphotoreceptor matrix proteoglycan 2b
chr21_-_2814709 2.25 ENSDART00000097664
semaphorin 4D
chr9_+_1162216 2.24 ENSDART00000165295
serine/threonine kinase 24a (STE20 homolog, yeast)
chr22_-_5744491 2.24 ENSDART00000145014
BCDIN3 domain containing
chr18_-_43866526 2.24 ENSDART00000111309
trehalase (brush-border membrane glycoprotein)
chr10_-_40348132 2.23 ENSDART00000150706
trace amine associated receptor 20h
chr2_+_3881000 2.23 ENSDART00000081897
membrane protein, palmitoylated 7b (MAGUK p55 subfamily member 7)
chr21_-_24865217 2.23 ENSDART00000101136
immunoglobulin superfamily, member 9Bb
chr10_-_40557210 2.23 ENSDART00000135297
trace amine associated receptor 18b
chr5_+_33498253 2.22 ENSDART00000140993
membrane-spanning 4-domains, subfamily A, member 17c.2
chr3_-_55139127 2.22 ENSDART00000115324
hemoglobin, alpha embryonic 1.3
chr23_-_14769523 2.22 ENSDART00000054909
glutathione synthetase
chr7_+_41812190 2.22 ENSDART00000113732
ENSDART00000174137
origin recognition complex, subunit 6
chr18_+_19101679 2.20 ENSDART00000139114
si:dkey-242h9.5
chr6_-_43616936 2.20 ENSDART00000149301
forkhead box P1b
chr7_+_36539124 2.19 ENSDART00000173653
chromodomain helicase DNA binding protein 9
chr19_-_44955710 2.18 ENSDART00000165246
si:ch211-233f16.1
chr7_+_22702437 2.17 ENSDART00000182054
si:dkey-165a24.9
chr1_-_57629639 2.17 ENSDART00000158984
zmp:0000001289
chr15_-_31366742 2.16 ENSDART00000125585
odorant receptor, family D, subfamily 111, member 3
chr10_-_36223005 2.16 ENSDART00000159962
odorant receptor, family D, subfamily 109, member 6
chr18_-_15559817 2.16 ENSDART00000061681
si:ch211-245j22.3
chr7_-_37917517 2.16 ENSDART00000173795
HEAT repeat containing 3
chr15_+_17030473 2.15 ENSDART00000129407
perilipin 2
chr22_+_19220459 2.15 ENSDART00000163070
si:dkey-21e2.7
chr24_+_12945803 2.13 ENSDART00000005105
proteasome activator subunit 1
chr2_+_21048661 2.12 ENSDART00000156876
ras responsive element binding protein 1b
chr7_-_28658143 2.12 ENSDART00000173556
adhesion G protein-coupled receptor G1
chr10_+_14982977 2.11 ENSDART00000140869
si:dkey-88l16.3
chr15_+_46853505 2.11 ENSDART00000159844
zgc:153039
chr15_-_36357889 2.11 ENSDART00000156377
si:dkey-23k10.5
chr13_-_11971148 2.11 ENSDART00000066230
ENSDART00000185614
zgc:110197
chr12_-_3962372 2.10 ENSDART00000016791
eukaryotic translation initiation factor 3, subunit C

Network of associatons between targets according to the STRING database.

First level regulatory network of nfe2l1b+nfe2l2b

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 20.2 GO:0030194 positive regulation of blood coagulation(GO:0030194) positive regulation of coagulation(GO:0050820) positive regulation of hemostasis(GO:1900048)
2.5 7.6 GO:0000256 allantoin catabolic process(GO:0000256)
1.9 7.5 GO:0010755 regulation of plasminogen activation(GO:0010755)
1.7 5.1 GO:0009162 deoxyribonucleoside monophosphate metabolic process(GO:0009162)
1.7 5.1 GO:0005991 trehalose metabolic process(GO:0005991)
1.6 4.8 GO:0006601 creatine metabolic process(GO:0006600) creatine biosynthetic process(GO:0006601)
1.5 9.2 GO:0032367 intracellular cholesterol transport(GO:0032367)
1.5 4.4 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
1.4 4.2 GO:0090008 hypoblast development(GO:0090008)
0.9 2.8 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.9 3.7 GO:0036445 neuronal stem cell division(GO:0036445) somatic stem cell division(GO:0048103)
0.9 4.6 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.9 2.7 GO:0050995 negative regulation of lipid catabolic process(GO:0050995)
0.9 3.6 GO:0010807 regulation of synaptic vesicle priming(GO:0010807)
0.9 5.3 GO:0006574 thymine catabolic process(GO:0006210) valine catabolic process(GO:0006574) thymine metabolic process(GO:0019859)
0.9 4.3 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.8 2.5 GO:0060631 regulation of meiosis I(GO:0060631)
0.8 3.9 GO:0046485 ether lipid metabolic process(GO:0046485)
0.7 3.0 GO:0098908 regulation of neuronal action potential(GO:0098908)
0.6 1.9 GO:0003223 ventricular compact myocardium morphogenesis(GO:0003223)
0.6 1.9 GO:0048340 paraxial mesoderm morphogenesis(GO:0048340) paraxial mesoderm formation(GO:0048341)
0.6 3.6 GO:0032218 riboflavin transport(GO:0032218)
0.6 17.1 GO:0019835 cytolysis(GO:0019835)
0.6 3.4 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.6 2.2 GO:1903798 regulation of production of small RNA involved in gene silencing by RNA(GO:0070920) regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903798)
0.5 12.6 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.5 2.5 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.4 3.1 GO:0045901 positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.4 1.3 GO:0044785 meiotic cell cycle phase transition(GO:0044771) metaphase/anaphase transition of meiotic cell cycle(GO:0044785) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994) regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902102) negative regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902103) regulation of meiotic chromosome separation(GO:1905132) negative regulation of meiotic chromosome separation(GO:1905133)
0.4 5.4 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.4 10.2 GO:0006884 cell volume homeostasis(GO:0006884)
0.4 1.5 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.4 5.1 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.4 3.2 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.4 2.1 GO:0070445 regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.4 1.4 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.3 1.0 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.3 1.7 GO:1901073 chitin biosynthetic process(GO:0006031) glucosamine-containing compound biosynthetic process(GO:1901073)
0.3 1.4 GO:0089709 L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.3 2.1 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
0.3 4.4 GO:0070189 kynurenine metabolic process(GO:0070189)
0.3 3.3 GO:0030104 water homeostasis(GO:0030104)
0.3 16.9 GO:0042738 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.3 4.1 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.3 2.2 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.3 2.4 GO:0031179 peptide modification(GO:0031179)
0.3 3.0 GO:0001765 membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.3 0.9 GO:0001779 natural killer cell differentiation(GO:0001779)
0.3 1.5 GO:2001293 malonyl-CoA metabolic process(GO:2001293)
0.3 4.4 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.3 7.9 GO:0006783 heme biosynthetic process(GO:0006783)
0.3 1.9 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.3 4.0 GO:0006775 fat-soluble vitamin metabolic process(GO:0006775)
0.3 4.8 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.3 2.0 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.2 2.7 GO:0031294 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.2 6.0 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.2 5.0 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.2 10.3 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.2 1.6 GO:0061511 centriole elongation(GO:0061511)
0.2 2.0 GO:0033077 T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594)
0.2 2.1 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.2 3.6 GO:0019433 triglyceride catabolic process(GO:0019433)
0.2 1.0 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.2 0.8 GO:0033119 negative regulation of RNA splicing(GO:0033119) negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.2 1.2 GO:0048260 positive regulation of receptor-mediated endocytosis(GO:0048260) protein localization to early endosome(GO:1902946)
0.2 3.9 GO:0014823 response to activity(GO:0014823)
0.2 16.9 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.2 1.2 GO:0060334 regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.2 0.6 GO:0061341 non-canonical Wnt signaling pathway involved in heart development(GO:0061341)
0.2 1.9 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.2 2.9 GO:0009651 response to salt stress(GO:0009651)
0.2 6.8 GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.2 1.3 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.2 5.9 GO:0007568 aging(GO:0007568)
0.2 1.6 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.2 1.4 GO:0051013 microtubule severing(GO:0051013)
0.2 1.9 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.2 4.4 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.2 0.5 GO:0033212 iron assimilation(GO:0033212)
0.2 1.5 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.2 2.7 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.2 0.5 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.2 0.8 GO:0045822 negative regulation of heart contraction(GO:0045822) negative regulation of blood circulation(GO:1903523)
0.1 2.8 GO:0005979 regulation of glycogen biosynthetic process(GO:0005979) regulation of glucan biosynthetic process(GO:0010962)
0.1 0.6 GO:0014826 regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.1 3.0 GO:0010257 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1 1.9 GO:0051445 regulation of meiotic cell cycle(GO:0051445)
0.1 0.4 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.1 1.9 GO:0005980 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.1 7.5 GO:0007602 phototransduction(GO:0007602)
0.1 4.5 GO:0001878 response to yeast(GO:0001878)
0.1 2.6 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.1 0.7 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.1 1.3 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.1 0.4 GO:0019418 sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)
0.1 2.6 GO:0030183 B cell differentiation(GO:0030183)
0.1 1.0 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.1 3.4 GO:0032506 cytokinetic process(GO:0032506)
0.1 1.5 GO:0006991 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.1 0.9 GO:0035188 hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.1 1.0 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.1 3.5 GO:0032526 response to retinoic acid(GO:0032526)
0.1 0.6 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.1 0.8 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.1 6.6 GO:0015914 phospholipid transport(GO:0015914)
0.1 0.7 GO:1901673 regulation of mitotic spindle assembly(GO:1901673)
0.1 0.8 GO:0035912 establishment of cell polarity involved in ameboidal cell migration(GO:0003365) aorta morphogenesis(GO:0035909) dorsal aorta morphogenesis(GO:0035912)
0.1 1.5 GO:0001516 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.1 0.5 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.1 5.7 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.1 2.2 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.1 0.7 GO:0048662 regulation of smooth muscle cell proliferation(GO:0048660) negative regulation of smooth muscle cell proliferation(GO:0048662)
0.1 3.1 GO:0002377 immunoglobulin production(GO:0002377)
0.1 7.7 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 4.9 GO:0050871 phagocytosis, recognition(GO:0006910) positive regulation of B cell activation(GO:0050871)
0.1 2.0 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.1 4.0 GO:0070830 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.1 0.4 GO:0035989 tendon development(GO:0035989)
0.1 1.3 GO:0046549 retinal cone cell development(GO:0046549)
0.1 2.1 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.1 2.7 GO:0000281 mitotic cytokinesis(GO:0000281)
0.1 1.8 GO:0006491 N-glycan processing(GO:0006491)
0.1 1.3 GO:0042574 retinal metabolic process(GO:0042574)
0.1 2.2 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.1 0.9 GO:0048769 sarcomerogenesis(GO:0048769)
0.1 1.2 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.1 2.2 GO:0006270 DNA replication initiation(GO:0006270)
0.1 3.1 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 1.1 GO:0046514 ceramide catabolic process(GO:0046514)
0.1 8.7 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.1 0.2 GO:0009182 purine deoxyribonucleoside diphosphate metabolic process(GO:0009182) deoxyribonucleoside triphosphate biosynthetic process(GO:0009202) dGDP metabolic process(GO:0046066)
0.1 1.5 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 0.3 GO:0044034 viral genome replication(GO:0019079) negative stranded viral RNA replication(GO:0039689) viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) multi-organism metabolic process(GO:0044033) multi-organism biosynthetic process(GO:0044034)
0.1 2.1 GO:2000045 regulation of G1/S transition of mitotic cell cycle(GO:2000045)
0.1 5.6 GO:0006334 nucleosome assembly(GO:0006334)
0.1 0.5 GO:0048532 anatomical structure arrangement(GO:0048532)
0.1 1.1 GO:0015671 gas transport(GO:0015669) oxygen transport(GO:0015671)
0.1 0.9 GO:0050926 regulation of positive chemotaxis(GO:0050926) positive regulation of positive chemotaxis(GO:0050927) induction of positive chemotaxis(GO:0050930)
0.1 2.3 GO:0051057 positive regulation of Ras protein signal transduction(GO:0046579) positive regulation of small GTPase mediated signal transduction(GO:0051057)
0.1 2.0 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.1 1.5 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.1 3.1 GO:0035082 axoneme assembly(GO:0035082)
0.1 0.7 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.0 5.1 GO:0031101 fin regeneration(GO:0031101)
0.0 0.9 GO:0051289 protein homotetramerization(GO:0051289)
0.0 0.8 GO:0007032 endosome organization(GO:0007032)
0.0 2.1 GO:0007062 sister chromatid cohesion(GO:0007062)
0.0 3.4 GO:0045930 negative regulation of mitotic cell cycle(GO:0045930)
0.0 0.6 GO:0007035 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.0 14.3 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 0.6 GO:0097061 dendritic spine morphogenesis(GO:0060997) dendritic spine organization(GO:0097061)
0.0 0.3 GO:0097477 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.0 1.0 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 0.4 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.0 2.8 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 0.8 GO:0015701 bicarbonate transport(GO:0015701)
0.0 1.4 GO:0042246 tissue regeneration(GO:0042246)
0.0 0.3 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.3 GO:0044380 protein localization to cytoskeleton(GO:0044380)
0.0 0.5 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 4.1 GO:0007601 visual perception(GO:0007601)
0.0 1.3 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)
0.0 6.7 GO:0000122 negative regulation of transcription from RNA polymerase II promoter(GO:0000122)
0.0 2.8 GO:0045666 positive regulation of neuron differentiation(GO:0045666)
0.0 2.7 GO:0042472 inner ear morphogenesis(GO:0042472)
0.0 1.8 GO:1990266 neutrophil migration(GO:1990266)
0.0 1.6 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.0 0.3 GO:0008089 anterograde axonal transport(GO:0008089)
0.0 2.6 GO:0048793 pronephros development(GO:0048793)
0.0 0.2 GO:0006517 protein deglycosylation(GO:0006517)
0.0 1.4 GO:0051028 mRNA transport(GO:0051028)
0.0 1.1 GO:0030100 regulation of endocytosis(GO:0030100)
0.0 1.2 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.0 2.2 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.0 1.1 GO:0000724 double-strand break repair via homologous recombination(GO:0000724)
0.0 1.9 GO:0006364 rRNA processing(GO:0006364)
0.0 1.6 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.2 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 2.7 GO:0060271 cilium morphogenesis(GO:0060271)
0.0 0.3 GO:0006360 transcription from RNA polymerase I promoter(GO:0006360)
0.0 0.7 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 2.1 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.4 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.9 15.0 GO:0005579 membrane attack complex(GO:0005579)
0.9 3.6 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.6 2.6 GO:0019815 B cell receptor complex(GO:0019815)
0.5 2.1 GO:0008537 proteasome activator complex(GO:0008537)
0.5 1.5 GO:0044316 cone cell pedicle(GO:0044316)
0.5 1.8 GO:0017177 glucosidase II complex(GO:0017177)
0.5 2.3 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.4 3.0 GO:1990130 Iml1 complex(GO:1990130)
0.4 6.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.3 0.9 GO:0097541 axonemal basal plate(GO:0097541)
0.3 2.1 GO:0001650 fibrillar center(GO:0001650)
0.3 4.1 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.3 3.2 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.3 6.8 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.3 16.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 1.0 GO:0031429 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.2 1.5 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 1.8 GO:0046930 pore complex(GO:0046930)
0.2 1.6 GO:0005663 DNA replication factor C complex(GO:0005663)
0.2 1.7 GO:0030428 cell septum(GO:0030428)
0.2 2.2 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.2 2.8 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 1.4 GO:0070652 HAUS complex(GO:0070652)
0.2 6.6 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.1 6.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 2.7 GO:0009925 basal plasma membrane(GO:0009925)
0.1 1.3 GO:0070449 elongin complex(GO:0070449)
0.1 4.7 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.1 12.7 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.1 1.8 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 2.1 GO:0016282 eukaryotic 43S preinitiation complex(GO:0016282)
0.1 4.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 2.2 GO:0045180 basal cortex(GO:0045180)
0.1 1.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 2.1 GO:0008278 cohesin complex(GO:0008278)
0.1 2.7 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.1 9.6 GO:0016324 apical plasma membrane(GO:0016324)
0.1 1.8 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 4.5 GO:0005643 nuclear pore(GO:0005643)
0.1 7.4 GO:0005795 Golgi stack(GO:0005795)
0.1 0.5 GO:0048500 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1 7.2 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 0.6 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 1.9 GO:0043186 P granule(GO:0043186)
0.1 5.6 GO:0000786 nucleosome(GO:0000786)
0.1 0.6 GO:0005903 brush border(GO:0005903)
0.1 6.4 GO:0005925 focal adhesion(GO:0005925)
0.0 0.9 GO:0042555 MCM complex(GO:0042555)
0.0 1.1 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 6.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 59.1 GO:0005615 extracellular space(GO:0005615)
0.0 2.1 GO:0005811 lipid particle(GO:0005811)
0.0 8.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 5.9 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.3 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.4 GO:0014704 intercalated disc(GO:0014704)
0.0 23.9 GO:0005576 extracellular region(GO:0005576)
0.0 1.4 GO:0005861 troponin complex(GO:0005861)
0.0 0.8 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.6 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 1.5 GO:0005840 ribosome(GO:0005840)
0.0 0.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.4 GO:0016342 catenin complex(GO:0016342)
0.0 0.3 GO:0036157 outer dynein arm(GO:0036157)
0.0 9.9 GO:0005815 microtubule organizing center(GO:0005815)
0.0 0.1 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 1.8 GO:0030018 Z disc(GO:0030018)
0.0 0.3 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.2 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 12.4 GO:0005783 endoplasmic reticulum(GO:0005783)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 13.7 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
1.7 5.1 GO:0004555 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
1.5 4.4 GO:0047804 cysteine-S-conjugate beta-lyase activity(GO:0047804)
1.0 3.1 GO:0016748 succinyltransferase activity(GO:0016748)
0.9 6.6 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.9 5.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.8 7.6 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.6 6.8 GO:0004046 aminoacylase activity(GO:0004046)
0.6 3.6 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.6 3.6 GO:0032217 riboflavin transporter activity(GO:0032217)
0.6 3.4 GO:0030548 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.5 9.0 GO:0031729 CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729)
0.5 6.8 GO:0016408 C-acyltransferase activity(GO:0016408)
0.5 1.9 GO:0004135 glycogen debranching enzyme activity(GO:0004133) 4-alpha-glucanotransferase activity(GO:0004134) amylo-alpha-1,6-glucosidase activity(GO:0004135)
0.5 3.8 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.5 3.2 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.5 1.8 GO:0001607 neuromedin U receptor activity(GO:0001607)
0.4 2.2 GO:0043295 glutathione binding(GO:0043295)
0.4 1.3 GO:0043878 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity(GO:0043878)
0.4 10.2 GO:0015379 cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379)
0.4 4.4 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.4 3.5 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.4 5.4 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.4 2.3 GO:0008142 oxysterol binding(GO:0008142)
0.4 1.5 GO:0033204 ribonuclease P RNA binding(GO:0033204)
0.4 3.4 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.4 1.9 GO:0004307 diacylglycerol cholinephosphotransferase activity(GO:0004142) ethanolaminephosphotransferase activity(GO:0004307)
0.4 1.8 GO:0015288 porin activity(GO:0015288)
0.4 2.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.3 1.0 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.3 13.6 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.3 2.3 GO:0004974 leukotriene receptor activity(GO:0004974)
0.3 3.0 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.3 4.2 GO:0070697 activin receptor binding(GO:0070697)
0.3 2.2 GO:0004984 olfactory receptor activity(GO:0004984) odorant binding(GO:0005549)
0.3 6.8 GO:0070492 oligosaccharide binding(GO:0070492)
0.3 3.8 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.3 3.2 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.3 2.4 GO:0036374 peptidyltransferase activity(GO:0000048) glutathione hydrolase activity(GO:0036374)
0.3 16.9 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.3 0.8 GO:0000810 diacylglycerol diphosphate phosphatase activity(GO:0000810)
0.2 2.7 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.2 0.9 GO:0072571 ADP-D-ribose binding(GO:0072570) mono-ADP-D-ribose binding(GO:0072571)
0.2 29.9 GO:0061135 endopeptidase inhibitor activity(GO:0004866) endopeptidase regulator activity(GO:0061135)
0.2 1.7 GO:0004100 chitin synthase activity(GO:0004100)
0.2 4.4 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 2.9 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.2 1.6 GO:0031419 cobalamin binding(GO:0031419)
0.2 1.8 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.2 12.9 GO:0001594 trace-amine receptor activity(GO:0001594)
0.2 2.8 GO:2001069 glycogen binding(GO:2001069)
0.2 7.8 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.2 1.8 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 0.5 GO:0001163 RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.2 0.9 GO:0042609 CD4 receptor binding(GO:0042609)
0.2 0.5 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086)
0.2 4.3 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
0.2 4.6 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.2 9.4 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.2 2.1 GO:0016783 sulfurtransferase activity(GO:0016783)
0.2 0.8 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.1 1.5 GO:0008242 omega peptidase activity(GO:0008242)
0.1 4.1 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.6 GO:0031708 endothelin B receptor binding(GO:0031708)
0.1 0.9 GO:0017040 ceramidase activity(GO:0017040)
0.1 1.6 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 7.5 GO:0009881 photoreceptor activity(GO:0009881)
0.1 3.9 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 9.3 GO:0003823 antigen binding(GO:0003823)
0.1 30.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 1.0 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.1 0.4 GO:0070224 sulfide:quinone oxidoreductase activity(GO:0070224)
0.1 24.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 1.0 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.1 8.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 0.8 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 1.4 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.1 2.0 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 1.6 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.1 0.6 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 2.1 GO:0031369 translation initiation factor binding(GO:0031369)
0.1 0.5 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.1 1.1 GO:0031720 haptoglobin binding(GO:0031720)
0.1 2.0 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.1 2.2 GO:0008171 O-methyltransferase activity(GO:0008171)
0.1 1.2 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 8.7 GO:0004896 cytokine receptor activity(GO:0004896)
0.1 6.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 0.8 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.1 3.9 GO:0015485 cholesterol binding(GO:0015485)
0.1 6.6 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.1 1.0 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.1 3.7 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 1.4 GO:0051011 microtubule minus-end binding(GO:0051011)
0.1 2.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.0 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.1 2.0 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.1 3.1 GO:0043022 ribosome binding(GO:0043022)
0.1 3.6 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.1 2.1 GO:0042923 neuropeptide binding(GO:0042923)
0.1 0.3 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.1 6.2 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.1 0.7 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 2.1 GO:0042562 hormone binding(GO:0042562)
0.0 1.3 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 3.5 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.6 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 3.1 GO:0003678 DNA helicase activity(GO:0003678)
0.0 1.8 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 1.8 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.5 GO:0031267 small GTPase binding(GO:0031267)
0.0 1.2 GO:0004629 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0 1.5 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.2 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 2.2 GO:0051082 unfolded protein binding(GO:0051082)
0.0 5.1 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 1.3 GO:0005178 integrin binding(GO:0005178)
0.0 0.3 GO:0045503 dynein light chain binding(GO:0045503)
0.0 4.3 GO:0042802 identical protein binding(GO:0042802)
0.0 2.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 2.8 GO:0008170 N-methyltransferase activity(GO:0008170)
0.0 0.7 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.4 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 3.8 GO:0016829 lyase activity(GO:0016829)
0.0 0.2 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 1.5 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 2.7 GO:0005179 hormone activity(GO:0005179)
0.0 0.6 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.2 GO:0052796 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0 1.6 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 1.4 GO:0045296 cadherin binding(GO:0045296)
0.0 0.2 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 1.0 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 4.7 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 1.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.5 GO:0015293 symporter activity(GO:0015293)
0.0 2.4 GO:0008134 transcription factor binding(GO:0008134)
0.0 0.5 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.0 1.2 GO:0008083 growth factor activity(GO:0008083)
0.0 0.7 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity(GO:0008757)
0.0 1.4 GO:0005125 cytokine activity(GO:0005125)
0.0 1.7 GO:0035091 phosphatidylinositol binding(GO:0035091)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 19.2 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.6 4.6 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.4 16.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.4 14.5 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.2 3.7 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.2 0.9 ST JAK STAT PATHWAY Jak-STAT Pathway
0.2 3.8 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 3.1 PID GLYPICAN 1PATHWAY Glypican 1 network
0.1 1.6 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 0.4 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.1 1.8 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.9 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.7 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 1.6 PID ATR PATHWAY ATR signaling pathway
0.0 5.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.2 PID BCR 5PATHWAY BCR signaling pathway
0.0 1.2 NABA COLLAGENS Genes encoding collagen proteins
0.0 1.8 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 1.7 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.2 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.4 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.7 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.6 PID RAC1 PATHWAY RAC1 signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 19.2 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
2.1 6.2 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
1.1 31.0 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.9 19.1 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.8 5.1 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.6 7.9 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.5 4.6 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.3 6.3 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.3 2.2 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.3 7.5 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.3 3.1 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.3 3.0 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.3 1.8 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.2 3.7 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 1.8 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.2 1.8 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 2.2 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 1.6 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.1 2.2 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1 15.8 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.1 3.0 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.6 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 1.2 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 1.0 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.1 1.6 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.1 2.7 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 0.9 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.1 1.9 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 1.5 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 3.1 REACTOME REGULATION OF APOPTOSIS Genes involved in Regulation of Apoptosis
0.1 1.0 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.1 6.5 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 1.4 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 1.2 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.6 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.8 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.4 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.0 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 2.4 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 1.0 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.1 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.7 REACTOME HOST INTERACTIONS OF HIV FACTORS Genes involved in Host Interactions of HIV factors
0.0 0.5 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 0.4 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 1.1 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 2.3 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.0 0.5 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 0.4 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.6 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)