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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for nkx1.2la

Z-value: 0.74

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Transcription factors associated with nkx1.2la

Gene Symbol Gene ID Gene Info
nkx1.2la
ENSDARG00000006350 NK1 transcription factor related 2-like,a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx1.2ladr11_v1_chr13_+_40770628_407706280.683.9e-14Click!

Activity profile of nkx1.2la motif

Sorted Z-values of nkx1.2la motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_21129752 11.45 ENSDART00000169764
syt1a
synaptotagmin Ia
chr2_-_38000276 11.09 ENSDART00000034790
pcp4l1
Purkinje cell protein 4 like 1
chr6_+_57541776 10.21 ENSDART00000157330
necab3
N-terminal EF-hand calcium binding protein 3
chr11_+_30057762 10.14 ENSDART00000164139
nhsb
Nance-Horan syndrome b (congenital cataracts and dental anomalies)
chr8_+_16025554 9.51 ENSDART00000110171
elavl4
ELAV like neuron-specific RNA binding protein 4
chr2_+_50608099 8.37 ENSDART00000185805
ENSDART00000111135
neurod6b
neuronal differentiation 6b
chr18_+_21408794 7.78 ENSDART00000140161
necab2
N-terminal EF-hand calcium binding protein 2
chr5_+_37903790 7.77 ENSDART00000162470
tmprss4b
transmembrane protease, serine 4b
chr17_-_12385308 7.45 ENSDART00000080927
snap25b
synaptosomal-associated protein, 25b
chr20_+_43925266 7.06 ENSDART00000037379
clic5b
chloride intracellular channel 5b
chr5_-_25723079 6.65 ENSDART00000014013
gda
guanine deaminase
chr15_-_33925851 6.61 ENSDART00000187807
ENSDART00000187780
mag
myelin associated glycoprotein
chr12_-_41684729 6.16 ENSDART00000184461
jakmip3
Janus kinase and microtubule interacting protein 3
chr1_-_50859053 6.14 ENSDART00000132779
ENSDART00000137648
si:dkeyp-123h10.2
si:dkeyp-123h10.2
chr21_+_6751760 6.05 ENSDART00000135914
olfm1b
olfactomedin 1b
chr4_+_9669717 5.75 ENSDART00000004604
si:dkey-153k10.9
si:dkey-153k10.9
chr21_+_6751405 5.28 ENSDART00000037265
ENSDART00000146371
olfm1b
olfactomedin 1b
chr10_+_37137464 5.17 ENSDART00000114909
cuedc1a
CUE domain containing 1a
chr23_+_28582865 5.15 ENSDART00000020296
l1cama
L1 cell adhesion molecule, paralog a
chr8_-_50888806 4.49 ENSDART00000053750
acsl2
acyl-CoA synthetase long chain family member 2
chr19_-_13286722 4.32 ENSDART00000168296
ENSDART00000158330
zfpm2b
zinc finger protein, FOG family member 2b
chr16_+_14033121 4.30 ENSDART00000135844
rusc1
RUN and SH3 domain containing 1
chr20_+_19512727 4.25 ENSDART00000063696
atraid
all-trans retinoic acid-induced differentiation factor
chr15_+_23799461 4.21 ENSDART00000154885
si:ch211-167j9.4
si:ch211-167j9.4
chr16_+_23984179 4.07 ENSDART00000175879
apoc2
apolipoprotein C-II
chr10_-_5581487 4.01 ENSDART00000141943
syk
spleen tyrosine kinase
chr6_+_7421898 3.96 ENSDART00000043946
ccdc65
coiled-coil domain containing 65
chr20_-_29864390 3.80 ENSDART00000161834
ENSDART00000132278
rnf144ab
ring finger protein 144ab
chr18_+_24919614 3.62 ENSDART00000008638
rgma
repulsive guidance molecule family member a
chr21_-_33995710 3.38 ENSDART00000100508
ENSDART00000179622
ebf1b
early B cell factor 1b
chr5_+_36611128 3.36 ENSDART00000097684
nova1
neuro-oncological ventral antigen 1
chr6_+_37301341 3.29 ENSDART00000104180
zranb2
zinc finger, RAN-binding domain containing 2
chr10_-_40968095 3.25 ENSDART00000184104
npffr1l1
neuropeptide FF receptor 1 like 1
chr21_-_43015383 3.22 ENSDART00000065097
dpysl3
dihydropyrimidinase-like 3
chr13_-_8692860 3.09 ENSDART00000058107
mcfd2
multiple coagulation factor deficiency 2
chr15_+_34592215 3.04 ENSDART00000099776
tspan13a
tetraspanin 13a
chr15_-_47115787 3.01 ENSDART00000192601
CABZ01079081.1

chr11_+_16152316 2.92 ENSDART00000081054
tada3l
transcriptional adaptor 3 (NGG1 homolog, yeast)-like
chr17_+_24318753 2.90 ENSDART00000064083
otx1
orthodenticle homeobox 1
chr7_+_54642005 2.87 ENSDART00000171864
fgf19
fibroblast growth factor 19
chr22_-_20011476 2.86 ENSDART00000093312
ENSDART00000093310
celf5a
cugbp, Elav-like family member 5a
chr11_-_21528056 2.86 ENSDART00000181626
srgap2
SLIT-ROBO Rho GTPase activating protein 2
chr1_-_19215336 2.81 ENSDART00000162949
ENSDART00000170680
ptprdb
protein tyrosine phosphatase, receptor type, D, b
chr20_-_42102416 2.77 ENSDART00000186378
ENSDART00000188253
ENSDART00000186458
slc35f1
solute carrier family 35, member F1
chr5_+_1079423 2.74 ENSDART00000172231
si:zfos-128g4.2
si:zfos-128g4.2
chr4_+_16885854 2.68 ENSDART00000017726
etnk1
ethanolamine kinase 1
chr5_-_51619742 2.67 ENSDART00000188537
otpb
orthopedia homeobox b
chr11_-_30158191 2.60 ENSDART00000155278
ENSDART00000156121
scml2
Scm polycomb group protein like 2
chr21_+_11834880 2.58 ENSDART00000081661
nudt2
nudix (nucleoside diphosphate linked moiety X)-type motif 2
chr18_+_17827149 2.56 ENSDART00000190237
ENSDART00000189345
ZNF423
si:ch211-216l23.1
chr22_-_26865361 2.43 ENSDART00000182504
hmox2a
heme oxygenase 2a
chr11_+_16153207 2.42 ENSDART00000192356
tada3l
transcriptional adaptor 3 (NGG1 homolog, yeast)-like
chr23_+_12134839 2.41 ENSDART00000128551
ENSDART00000141204
ttll9
tubulin tyrosine ligase-like family, member 9
chr24_-_21689146 2.39 ENSDART00000105917
urad
ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase
chr15_-_14552101 2.28 ENSDART00000171169
numbl
numb homolog (Drosophila)-like
chr15_-_30505607 2.27 ENSDART00000155212
msi2b
musashi RNA-binding protein 2b
chr8_+_18011522 2.24 ENSDART00000136756
ssbp3b
single stranded DNA binding protein 3b
chr20_-_13774826 2.23 ENSDART00000063831
opn8c
opsin 8, group member c
chr13_-_8692432 2.22 ENSDART00000058106
mcfd2
multiple coagulation factor deficiency 2
chr1_+_33668236 2.11 ENSDART00000122316
ENSDART00000102184
arl13b
ADP-ribosylation factor-like 13b
chr14_-_4556896 2.07 ENSDART00000044678
ENSDART00000192863
GABRA2
gamma-aminobutyric acid type A receptor alpha2 subunit
chr16_+_23975930 2.05 ENSDART00000147858
ENSDART00000144347
ENSDART00000115270
apoc4
apolipoprotein C-IV
chr10_+_17235370 2.05 ENSDART00000038780
sppl3
signal peptide peptidase 3
chr15_+_15856178 2.05 ENSDART00000080338
dusp14
dual specificity phosphatase 14
chr6_-_12275836 2.03 ENSDART00000189980
pkp4
plakophilin 4
chr24_-_31425799 2.02 ENSDART00000157998
cngb3.1
cyclic nucleotide gated channel beta 3, tandem duplicate 1
chr6_-_40922971 1.95 ENSDART00000155363
sfi1
SFI1 centrin binding protein
chr22_-_8725768 1.94 ENSDART00000189873
ENSDART00000181819
si:ch73-27e22.1
si:ch73-27e22.8
si:ch73-27e22.1
si:ch73-27e22.8
chr23_-_20051369 1.91 ENSDART00000049836
bgnb
biglycan b
chr4_+_11458078 1.81 ENSDART00000037600
ankrd16
ankyrin repeat domain 16
chr7_+_34620418 1.76 ENSDART00000081338
slc9a5
solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
chr23_-_15216654 1.75 ENSDART00000131649
sulf2b
sulfatase 2b
chr17_+_43032529 1.71 ENSDART00000055611
ENSDART00000154863
isca2
iron-sulfur cluster assembly 2
chr16_+_23976227 1.70 ENSDART00000193013
apoc4
apolipoprotein C-IV
chr8_-_13184989 1.69 ENSDART00000135738
zgc:194990
zgc:194990
chr22_-_10055744 1.69 ENSDART00000143686
si:ch211-222k6.2
si:ch211-222k6.2
chr16_-_31351419 1.67 ENSDART00000178298
ENSDART00000018091
mroh1
maestro heat-like repeat family member 1
chr4_+_5255041 1.66 ENSDART00000137966
ccdc167
coiled-coil domain containing 167
chr4_+_9400012 1.63 ENSDART00000191960
tmtc1
transmembrane and tetratricopeptide repeat containing 1
chr1_-_19502322 1.60 ENSDART00000181888
ENSDART00000044030
kitb
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog b
chr5_-_68074592 1.58 ENSDART00000165052
ENSDART00000018792
spag7
sperm associated antigen 7
chr16_+_32051572 1.58 ENSDART00000039109
leng1
leukocyte receptor cluster (LRC) member 1
chr1_-_28860732 1.52 ENSDART00000177588
timmdc1
translocase of inner mitochondrial membrane domain containing 1
chr19_+_5480327 1.49 ENSDART00000148794
jupb
junction plakoglobin b
chr13_-_9886579 1.35 ENSDART00000101926
si:ch211-117n7.7
si:ch211-117n7.7
chr21_-_2341937 1.29 ENSDART00000158459
zgc:193790
zgc:193790
chr8_+_11325310 1.22 ENSDART00000142577
fxn
frataxin
chr4_-_2975461 1.16 ENSDART00000150794
plekha5
pleckstrin homology domain containing, family A member 5
chr4_-_3353595 1.15 ENSDART00000009076
pik3cg
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
chr21_-_15200556 1.11 ENSDART00000141809
sfswap
splicing factor SWAP
chr22_-_26865181 1.10 ENSDART00000138311
hmox2a
heme oxygenase 2a
chr4_-_61691066 1.09 ENSDART00000159114
znf1129
zinc finger protein 1129
chr14_+_30795559 1.08 ENSDART00000006132
cfl1
cofilin 1
chr11_+_2506516 1.04 ENSDART00000130886
ENSDART00000189767
NABP2
si:ch73-190f16.2
chr1_+_15258641 1.02 ENSDART00000033018
pi4k2b
phosphatidylinositol 4-kinase type 2 beta
chr1_-_33351780 1.01 ENSDART00000178996
gyg2
glycogenin 2
chr7_-_40630698 1.00 ENSDART00000134547
ube3c
ubiquitin protein ligase E3C
chr11_-_29737088 0.96 ENSDART00000159828
si:ch211-218g23.6
si:ch211-218g23.6
chr17_+_15983557 0.95 ENSDART00000190806
clmn
calmin
chr18_+_7073130 0.94 ENSDART00000101216
ENSDART00000148947
si:dkey-88e18.2
si:dkey-88e18.2
chr5_+_13394543 0.94 ENSDART00000051669
ENSDART00000135921
tctn2
tectonic family member 2
chr16_-_27677930 0.90 ENSDART00000145991
tbrg4
transforming growth factor beta regulator 4
chr16_-_30434279 0.87 ENSDART00000018504
zgc:77086
zgc:77086
chr25_+_19489370 0.80 ENSDART00000091132
glsl
glutaminase like
chr25_+_20715950 0.79 ENSDART00000180223
ergic2
ERGIC and golgi 2
chr10_-_5847655 0.75 ENSDART00000192773
ankrd55
ankyrin repeat domain 55
chr7_-_31922432 0.70 ENSDART00000188398
lin7c
lin-7 homolog C (C. elegans)
chr11_-_16152400 0.69 ENSDART00000123665
arpc4l
actin related protein 2/3 complex, subunit 4, like
chr9_-_41062412 0.68 ENSDART00000193879
ankar
ankyrin and armadillo repeat containing
chr16_-_32837806 0.67 ENSDART00000003997
MCHR2
si:dkey-165n16.5
chr9_-_11676491 0.66 ENSDART00000022358
zc3h15
zinc finger CCCH-type containing 15
chr8_-_39822917 0.60 ENSDART00000067843
zgc:162025
zgc:162025
chr21_+_13387965 0.59 ENSDART00000134347
zgc:113162
zgc:113162
chr7_+_6652967 0.59 ENSDART00000102681
pnp5a
purine nucleoside phosphorylase 5a
chr2_+_53204750 0.58 ENSDART00000163644
zgc:165603
zgc:165603
chr13_+_10621257 0.54 ENSDART00000008603
prepl
prolyl endopeptidase-like
chr21_+_21195487 0.54 ENSDART00000181746
ENSDART00000184832
rictorb
RPTOR independent companion of MTOR, complex 2b
chr16_-_31622777 0.53 ENSDART00000137311
ENSDART00000002930
phf20l1
PHD finger protein 20 like 1
chr10_-_28118035 0.53 ENSDART00000190836
ENSDART00000088852
med13a
mediator complex subunit 13a
chr20_+_29209615 0.52 ENSDART00000062350
katnbl1
katanin p80 subunit B-like 1
chr12_+_30706158 0.48 ENSDART00000133869
kcnk1a
potassium channel, subfamily K, member 1a
chr20_+_28803977 0.47 ENSDART00000153351
ENSDART00000038149
fntb
farnesyltransferase, CAAX box, beta
chr11_-_39118882 0.46 ENSDART00000113185
ENSDART00000156526
ap5b1
adaptor-related protein complex 5, beta 1 subunit
chr24_-_29586082 0.45 ENSDART00000136763
vav3a
vav 3 guanine nucleotide exchange factor a
chr25_+_34938317 0.45 ENSDART00000042678
vps4a
vacuolar protein sorting 4a homolog A (S. cerevisiae)
chr21_+_45223194 0.43 ENSDART00000150902
si:ch73-269m14.3
si:ch73-269m14.3
chr8_+_18588551 0.41 ENSDART00000177476
ENSDART00000063539
prrg1
proline rich Gla (G-carboxyglutamic acid) 1
chr20_+_29209767 0.40 ENSDART00000141252
katnbl1
katanin p80 subunit B-like 1
chr8_-_51930826 0.40 ENSDART00000109785
cabin1
calcineurin binding protein 1
chr8_-_25034411 0.38 ENSDART00000135973
nfyal
nuclear transcription factor Y, alpha, like
chr23_-_1660708 0.37 ENSDART00000175138
CU693481.1

chr22_+_9522971 0.36 ENSDART00000110048
strip1
striatin interacting protein 1
chr14_-_14659023 0.36 ENSDART00000170355
ENSDART00000159888
ENSDART00000172241
nsdhl
NAD(P) dependent steroid dehydrogenase-like
chr2_-_20788698 0.36 ENSDART00000181823
CABZ01020455.1

chr23_+_29885019 0.36 ENSDART00000167059
aurkaip1
aurora kinase A interacting protein 1
chr15_+_45640906 0.35 ENSDART00000149361
ENSDART00000149079
sagb
S-antigen; retina and pineal gland (arrestin) b
chr13_-_10620652 0.32 ENSDART00000135000
ENSDART00000191587
si:ch73-54n14.2
camkmt
si:ch73-54n14.2
calmodulin-lysine N-methyltransferase
chr7_-_50410524 0.31 ENSDART00000083346
hypk
huntingtin interacting protein K
chr4_-_45115963 0.30 ENSDART00000137248
si:dkey-51d8.6
si:dkey-51d8.6
chr7_-_8712148 0.28 ENSDART00000065488
tex261
testis expressed 261
chr1_-_7970653 0.25 ENSDART00000188909
si:dkey-79f11.7
si:dkey-79f11.7
chr17_+_21964472 0.24 ENSDART00000063704
ENSDART00000188904
crip3
cysteine-rich protein 3
chr9_+_43799829 0.23 ENSDART00000186240
ube2e3
ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
chr20_-_47188966 0.17 ENSDART00000152965
si:dkeyp-104f11.9
si:dkeyp-104f11.9
chr20_+_29209926 0.17 ENSDART00000152949
ENSDART00000153016
katnbl1
katanin p80 subunit B-like 1
chr3_-_39180048 0.16 ENSDART00000049720
cdk21
cyclin-dependent kinase 21
chr4_+_11723852 0.14 ENSDART00000028820
mkln1
muskelin 1, intracellular mediator containing kelch motifs
chr6_+_40832635 0.10 ENSDART00000011931
ruvbl1
RuvB-like AAA ATPase 1
chr22_-_5252005 0.03 ENSDART00000132942
ENSDART00000081801
ncln
nicalin
chr9_+_35015747 0.00 ENSDART00000140110
gabpa
GA binding protein transcription factor, alpha subunit

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx1.2la

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 18.0 GO:0042983 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
2.2 6.6 GO:0006145 purine nucleobase catabolic process(GO:0006145)
1.3 4.0 GO:0045579 positive regulation of B cell differentiation(GO:0045579)
1.1 4.2 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.8 2.4 GO:0019628 allantoin metabolic process(GO:0000255) urate catabolic process(GO:0019628) urate metabolic process(GO:0046415)
0.7 3.6 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.7 2.1 GO:1903441 receptor localization to nonmotile primary cilium(GO:0097500) protein localization to ciliary membrane(GO:1903441)
0.6 3.5 GO:0006788 heme oxidation(GO:0006788)
0.6 2.9 GO:2001223 negative regulation of neuron migration(GO:2001223)
0.5 7.5 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.5 11.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.5 4.0 GO:0003352 regulation of cilium movement(GO:0003352)
0.4 2.7 GO:0021767 mammillary body development(GO:0021767)
0.4 1.6 GO:0038093 Fc receptor signaling pathway(GO:0038093)
0.4 1.1 GO:0030043 actin filament fragmentation(GO:0030043)
0.3 1.5 GO:0002159 desmosome assembly(GO:0002159)
0.3 2.6 GO:0006167 AMP biosynthetic process(GO:0006167)
0.3 1.3 GO:0006660 phosphatidylserine catabolic process(GO:0006660) monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.3 3.2 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.2 1.7 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.2 2.1 GO:0006465 signal peptide processing(GO:0006465)
0.2 5.2 GO:0045773 positive regulation of axon extension(GO:0045773)
0.2 4.1 GO:0042953 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.2 1.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.2 4.5 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.2 2.9 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.2 1.8 GO:1990118 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 5.3 GO:0043966 histone H3 acetylation(GO:0043966)
0.1 2.3 GO:0021772 olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988)
0.1 0.7 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.1 2.4 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 0.5 GO:0018343 protein farnesylation(GO:0018343)
0.1 2.0 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.1 0.9 GO:0044528 regulation of mitochondrial mRNA stability(GO:0044528)
0.1 13.0 GO:0002088 lens development in camera-type eye(GO:0002088)
0.1 0.6 GO:0097065 anterior head development(GO:0097065)
0.1 0.8 GO:0006537 glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543)
0.1 2.9 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 0.9 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.1 1.2 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 3.8 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.1 2.3 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 1.2 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 5.7 GO:0007605 sensory perception of sound(GO:0007605)
0.1 1.0 GO:0007032 endosome organization(GO:0007032)
0.0 0.5 GO:0038203 TORC2 signaling(GO:0038203)
0.0 3.4 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 2.2 GO:0007602 phototransduction(GO:0007602)
0.0 0.4 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.0 0.3 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
0.0 3.2 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 9.2 GO:0008380 RNA splicing(GO:0008380)
0.0 0.2 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.7 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 1.0 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 2.0 GO:0007601 visual perception(GO:0007601)
0.0 0.5 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.8 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.1 GO:0060420 regulation of heart growth(GO:0060420)
0.0 4.9 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 4.3 GO:0000122 negative regulation of transcription from RNA polymerase II promoter(GO:0000122)
0.0 2.0 GO:0042742 defense response to bacterium(GO:0042742)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 11.4 GO:0042584 chromaffin granule membrane(GO:0042584)
1.2 7.5 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.5 2.1 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.5 4.1 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.4 5.2 GO:0044295 axonal growth cone(GO:0044295)
0.4 4.1 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.2 10.0 GO:0043204 perikaryon(GO:0043204)
0.2 4.0 GO:0005858 axonemal dynein complex(GO:0005858)
0.2 0.7 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.2 3.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 10.2 GO:0031985 Golgi cisterna(GO:0031985)
0.1 2.9 GO:0045335 dendritic spine head(GO:0044327) phagocytic vesicle(GO:0045335)
0.1 0.5 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.1 1.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 7.1 GO:0034707 chloride channel complex(GO:0034707)
0.1 2.1 GO:0060170 ciliary membrane(GO:0060170)
0.1 1.5 GO:0030057 desmosome(GO:0030057)
0.1 0.9 GO:0036038 MKS complex(GO:0036038)
0.1 2.3 GO:0005844 polysome(GO:0005844)
0.0 0.5 GO:0044545 NSL complex(GO:0044545)
0.0 0.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.8 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 4.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.1 GO:0097255 R2TP complex(GO:0097255)
0.0 0.5 GO:0031932 TORC2 complex(GO:0031932)
0.0 4.2 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.5 GO:0030426 growth cone(GO:0030426)
0.0 2.4 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.3 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.5 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.0 9.0 GO:0030054 cell junction(GO:0030054)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0030882 lipid antigen binding(GO:0030882)
1.0 5.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.6 3.5 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.4 4.5 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.4 6.6 GO:0033691 sialic acid binding(GO:0033691)
0.3 3.2 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.3 2.1 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.2 11.4 GO:0001786 phosphatidylserine binding(GO:0001786)
0.2 3.6 GO:0015026 coreceptor activity(GO:0015026)
0.2 7.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.2 0.7 GO:0097016 L27 domain binding(GO:0097016)
0.2 2.4 GO:0070739 protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.2 2.6 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.2 1.5 GO:0045294 alpha-catenin binding(GO:0045294)
0.2 1.8 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.2 2.0 GO:0005223 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.2 1.2 GO:0016530 metallochaperone activity(GO:0016530)
0.1 1.0 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 1.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 2.9 GO:0031267 small GTPase binding(GO:0031267)
0.1 7.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 1.6 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1 0.5 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.1 4.8 GO:0019239 deaminase activity(GO:0019239)
0.1 1.2 GO:0052812 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.1 1.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 2.1 GO:0033549 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.1 5.3 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 2.9 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 3.8 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 0.8 GO:0004359 glutaminase activity(GO:0004359)
0.1 7.1 GO:0005254 chloride channel activity(GO:0005254)
0.1 0.6 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.1 4.3 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 1.7 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 2.4 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 2.2 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 3.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 2.6 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 0.4 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 0.5 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 6.2 GO:0019900 kinase binding(GO:0019900)
0.0 2.0 GO:0045296 cadherin binding(GO:0045296)
0.0 2.2 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.1 GO:0043139 5'-3' DNA helicase activity(GO:0043139)
0.0 0.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 18.0 GO:0005509 calcium ion binding(GO:0005509)
0.0 5.8 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 2.8 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 7.5 GO:0046983 protein dimerization activity(GO:0046983)
0.0 1.6 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 2.6 GO:0042393 histone binding(GO:0042393)
0.0 0.2 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.0 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.1 1.1 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 4.3 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 6.6 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.1 3.6 PID BMP PATHWAY BMP receptor signaling
0.1 1.2 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.1 2.9 PID FGF PATHWAY FGF signaling pathway
0.1 1.2 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.4 PID AURORA A PATHWAY Aurora A signaling
0.0 0.4 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 6.6 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.4 4.1 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.3 2.9 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.3 3.2 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 1.1 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.2 2.7 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.2 4.0 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.2 3.7 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.1 2.1 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 5.3 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.1 2.2 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 3.6 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 1.0 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 1.8 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.2 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 2.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.5 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis