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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for nkx1.2lb

Z-value: 0.69

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Transcription factors associated with nkx1.2lb

Gene Symbol Gene ID Gene Info
ENSDARG00000099427 NK1 transcription factor related 2-like,b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx1.2lbdr11_v1_chr14_+_15064870_15064870-0.312.2e-03Click!

Activity profile of nkx1.2lb motif

Sorted Z-values of nkx1.2lb motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_34002185 7.81 ENSDART00000046599
zygote arrest 1-like
chr24_-_28245872 5.91 ENSDART00000167861
cytochrome c oxidase subunit IV isoform 1, like
chr23_-_24263474 5.71 ENSDART00000160312
heat shock protein family, member 7 (cardiovascular)
chr25_-_27819838 5.22 ENSDART00000067106
leiomodin 2 (cardiac) a
chr6_+_6924637 4.80 ENSDART00000065551
ENSDART00000151393
sterile alpha motif and leucine zipper containing kinase AZK
chr23_-_44965582 4.52 ENSDART00000163367
transferrin receptor 2
chr8_-_23780334 4.37 ENSDART00000145179
ENSDART00000145894
zgc:195245
chr12_+_3078221 4.27 ENSDART00000148835
ENSDART00000149427
sarcoglycan, alpha
chr23_-_35064785 4.11 ENSDART00000172240

chr13_-_17723417 3.92 ENSDART00000183834
voltage-dependent anion channel 2
chr7_+_54642005 3.87 ENSDART00000171864
fibroblast growth factor 19
chr6_-_7720332 3.76 ENSDART00000135945
ribosomal protein SA
chr19_-_18313303 3.72 ENSDART00000164644
ENSDART00000167480
ENSDART00000163104
si:dkey-208k4.2
chr2_+_6253246 3.67 ENSDART00000058256
ENSDART00000076700
zona pellucida glycoprotein 3b
chr19_-_9662958 3.51 ENSDART00000041094
chloride channel, voltage-sensitive 1a
chr20_-_14114078 3.07 ENSDART00000168434
ENSDART00000104032
si:ch211-223m11.2
chr6_+_28051978 3.06 ENSDART00000143218
si:ch73-194h10.2
chr9_-_21912227 2.91 ENSDART00000145576
LIM domain 7a
chr17_+_16429826 2.80 ENSDART00000136078
EF-hand calcium binding domain 11
chr9_-_50000144 2.69 ENSDART00000123416
sodium channel, voltage-gated, type I, alpha
chr20_+_43925266 2.63 ENSDART00000037379
chloride intracellular channel 5b
chr17_-_53329704 2.55 ENSDART00000193895
exonuclease 3'-5' domain containing 1
chr13_-_36798204 2.46 ENSDART00000012357
salvador family WW domain containing protein 1
chr20_+_14114258 2.43 ENSDART00000044937
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3b
chr12_-_19119176 2.39 ENSDART00000149180
aconitase 2, mitochondrial
chr22_-_35330532 2.27 ENSDART00000172654

chr16_+_54263921 2.24 ENSDART00000002856
dopamine receptor D2 like
chr23_+_43255328 2.24 ENSDART00000102712
transglutaminase 2, C polypeptide A
chr6_-_54179860 2.15 ENSDART00000164283
ribosomal protein S10
chr21_+_16145980 1.85 ENSDART00000135119
pyroglutamylated RFamide peptide receptor 4
chr25_+_36312459 1.84 ENSDART00000182484

chr15_+_9327252 1.84 ENSDART00000144381
sarcoglycan, gamma
chr2_-_52020049 1.79 ENSDART00000128198
ENSDART00000135331
sodium channel, voltage gated, type XII, alpha a
chr19_-_3255725 1.76 ENSDART00000105165
immune-related, lectin-like receptor 1
chr21_+_4368735 1.70 ENSDART00000182817

chr5_-_67629263 1.66 ENSDART00000133753
zinc finger and BTB domain containing 20
chr16_-_11798994 1.65 ENSDART00000135408
cornifelin
chr1_-_17715493 1.63 ENSDART00000133027
si:dkey-256e7.8
chr21_+_4410733 1.61 ENSDART00000136831
ENSDART00000131612
si:dkey-84o3.7
chr3_+_17537352 1.52 ENSDART00000104549
hypocretin (orexin) neuropeptide precursor
chr21_+_4348600 1.49 ENSDART00000138463
si:dkey-84o3.2
chr13_-_9213207 1.49 ENSDART00000139861
ENSDART00000140524
si:dkey-33c12.11
chr21_-_21570134 1.42 ENSDART00000174388
odorant receptor, family H, subfamily 133, member 4
chr1_-_44812014 1.40 ENSDART00000139044
si:dkey-9i23.8
chr22_+_30089054 1.35 ENSDART00000185369
adducin 3 (gamma) a
chr2_+_19522082 1.34 ENSDART00000146098
Pim proto-oncogene, serine/threonine kinase, related 49
chr21_+_4328348 1.33 ENSDART00000131658
ENSDART00000143799
si:dkey-84o3.7
chr20_-_16972351 1.33 ENSDART00000148312
ENSDART00000186702
si:ch73-74h11.1
chr13_+_9468535 1.28 ENSDART00000135088
ENSDART00000164270
ENSDART00000099619
ENSDART00000164656
si:dkey-265c15.6
chr7_+_34453185 1.25 ENSDART00000173875
ENSDART00000173921
ENSDART00000173995
si:cabz01009626.1
chr17_-_15189397 1.23 ENSDART00000133710
ENSDART00000110507
WD repeat and HMG-box DNA binding protein 1
chr13_-_9236905 1.23 ENSDART00000142597
ENSDART00000147176
ENSDART00000181670
si:dkey-33c12.12
si:dkey-112g5.12
chr13_+_9496748 1.22 ENSDART00000147050
ENSDART00000102120

chr4_-_29753895 1.20 ENSDART00000150742
si:dkey-191j3.1
chr10_+_39212898 1.15 ENSDART00000159501
STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
chr21_+_4429001 1.14 ENSDART00000134520
si:dkey-84o3.6
chr13_-_9070754 1.14 ENSDART00000143783
ENSDART00000102121
ENSDART00000140820
ENSDART00000184210
si:dkey-112g5.12
chr13_-_30142087 1.09 ENSDART00000110157
trypsin domain containing 1
chr2_+_10007113 1.08 ENSDART00000155213
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3b
chr11_-_2131280 1.07 ENSDART00000008409
calcium binding and coiled-coil domain 1b
chr4_+_63790028 1.05 ENSDART00000160964
si:dkey-92j16.2
chr13_+_35955562 1.04 ENSDART00000137377
si:ch211-67f13.7
chr14_-_30945515 1.02 ENSDART00000161540
si:zfos-80g12.1
chr4_+_306036 1.02 ENSDART00000103659
mesogenin 1
chr2_+_25315591 1.01 ENSDART00000161386
fibronectin type III domain containing 3Ba
chr11_+_31864921 0.96 ENSDART00000180252
diaphanous-related formin 3
chr1_+_55758257 0.95 ENSDART00000139312
trans-2,3-enoyl-CoA reductase b
chr8_-_17822259 0.92 ENSDART00000063587
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5b
chr13_-_9159852 0.87 ENSDART00000170185
ENSDART00000158697
ENSDART00000143393
ENSDART00000164973
ENSDART00000159910
si:dkey-112g5.16
chr14_+_1687357 0.85 ENSDART00000174675
histamine receptor H2a
chr25_+_469855 0.84 ENSDART00000104717
ribosomal L24 domain containing 1
chr13_-_9111927 0.81 ENSDART00000133815
ENSDART00000109783
ENSDART00000142540
ENSDART00000192613
si:dkey-19p15.4
si:dkey-112g5.12
chr13_-_9184132 0.81 ENSDART00000135289
ENSDART00000136309
ENSDART00000132630
si:dkey-33c12.10
chr13_+_9521629 0.81 ENSDART00000149870
ENSDART00000137666
si:dkey-19p15.4
chr7_+_24881680 0.80 ENSDART00000058843
kelch repeat-containing protein
chr13_-_9045879 0.80 ENSDART00000155463
ENSDART00000140041
ENSDART00000137454
si:dkey-112g5.11
chr2_+_19578079 0.77 ENSDART00000144413
Pim proto-oncogene, serine/threonine kinase, related 50
chr8_+_7756893 0.73 ENSDART00000191894
FYVE, RhoGEF and PH domain containing 1
chr16_+_16849220 0.70 ENSDART00000047409
ENSDART00000142155
myosin, heavy chain 14, non-muscle
chr23_-_1348933 0.69 ENSDART00000168981

chr4_-_9891874 0.60 ENSDART00000067193
adrenomedullin 2a
chr14_+_918287 0.56 ENSDART00000167066

chr24_-_32582378 0.54 ENSDART00000066590
retinol dehydrogenase 12, like
chr13_-_9257728 0.52 ENSDART00000145985
ENSDART00000169991
ENSDART00000132764
zgc:173425
chr25_+_20272145 0.50 ENSDART00000109605
si:dkey-219c3.2
chr2_+_10006839 0.50 ENSDART00000160304
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3b
chr4_-_45115963 0.47 ENSDART00000137248
si:dkey-51d8.6
chr5_-_3991655 0.45 ENSDART00000159368
myosin XIX
chr16_+_4078240 0.43 ENSDART00000160890
inositol polyphosphate-5-phosphatase B
chr4_-_48957129 0.40 ENSDART00000150426
zinc finger protein 1064
chr5_-_51619742 0.40 ENSDART00000188537
orthopedia homeobox b
chr7_+_20384408 0.40 ENSDART00000173809
si:dkey-33c9.6
chr15_-_14552101 0.39 ENSDART00000171169
numb homolog (Drosophila)-like
chr4_+_11458078 0.36 ENSDART00000037600
ankyrin repeat domain 16
chr14_-_30587814 0.35 ENSDART00000144912
ENSDART00000149714
transmembrane protein 265
chr23_-_31913069 0.31 ENSDART00000135526
mitochondrial fission regulator 2
chr8_-_39822917 0.31 ENSDART00000067843
zgc:162025
chr8_+_21384288 0.27 ENSDART00000079263
forkhead-associated (FHA) phosphopeptide binding domain 1
chr9_+_1313418 0.25 ENSDART00000191361
caspase 8, apoptosis-related cysteine peptidase, like 2
chr4_-_44611273 0.24 ENSDART00000156793
zinc finger protein 1115
chr4_-_42039794 0.23 ENSDART00000110313
si:dkeyp-85d8.5
chr9_+_35015747 0.21 ENSDART00000140110
GA binding protein transcription factor, alpha subunit
chr13_+_12761707 0.21 ENSDART00000015127
zgc:100846
chr7_+_20383841 0.16 ENSDART00000052906
si:dkey-33c9.6
chr6_+_23026714 0.15 ENSDART00000124948
signal recognition particle 68
chr1_-_20928772 0.10 ENSDART00000078277
methylsterol monooxygenase 1
chr2_+_35728033 0.09 ENSDART00000002094
ankyrin repeat domain 45
chr8_-_20243389 0.04 ENSDART00000184904
alkaline ceramidase 1
chr8_-_4031121 0.01 ENSDART00000169474
ENSDART00000163754
myotubularin related protein 3

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx1.2lb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.5 GO:0072512 ferric iron transport(GO:0015682) transferrin transport(GO:0033572) trivalent inorganic cation transport(GO:0072512)
0.8 5.7 GO:0003319 cardioblast migration to the midline involved in heart rudiment formation(GO:0003319)
0.6 5.2 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.5 5.9 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.4 1.5 GO:0042755 eating behavior(GO:0042755)
0.3 1.0 GO:0048341 paraxial mesoderm morphogenesis(GO:0048340) paraxial mesoderm formation(GO:0048341)
0.3 0.8 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.3 4.7 GO:0060046 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.3 5.9 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.2 3.9 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.2 2.2 GO:0051967 negative regulation of cytosolic calcium ion concentration(GO:0051481) negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 1.0 GO:0043201 response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031)
0.1 2.6 GO:0034587 piRNA metabolic process(GO:0034587)
0.1 3.9 GO:0048665 neuron fate specification(GO:0048665)
0.1 1.1 GO:0031998 regulation of fatty acid beta-oxidation(GO:0031998)
0.1 0.4 GO:0071871 response to monoamine(GO:0071867) response to catecholamine(GO:0071869) response to epinephrine(GO:0071871)
0.1 1.6 GO:0090481 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.1 1.8 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.1 2.2 GO:0018149 peptide cross-linking(GO:0018149)
0.1 0.9 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 0.4 GO:0021767 mammillary body development(GO:0021767)
0.1 2.4 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.1 3.5 GO:0030050 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.1 1.2 GO:0043687 protein N-linked glycosylation via asparagine(GO:0018279) post-translational protein modification(GO:0043687)
0.1 0.3 GO:0097065 anterior head development(GO:0097065)
0.0 6.1 GO:0006821 chloride transport(GO:0006821)
0.0 1.4 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 0.2 GO:0036268 swimming(GO:0036268)
0.0 1.0 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.0 1.4 GO:0007602 phototransduction(GO:0007602)
0.0 0.3 GO:0009060 aerobic respiration(GO:0009060)
0.0 0.7 GO:0046847 filopodium assembly(GO:0046847)
0.0 2.4 GO:0051260 protein homooligomerization(GO:0051260)
0.0 1.1 GO:0006414 translational elongation(GO:0006414)
0.0 6.9 GO:0006412 translation(GO:0006412)
0.0 0.4 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 2.9 GO:0030155 regulation of cell adhesion(GO:0030155)
0.0 1.8 GO:0048738 cardiac muscle tissue development(GO:0048738)
0.0 0.5 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 1.2 GO:0006261 DNA-dependent DNA replication(GO:0006261)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 6.1 GO:0016012 sarcoglycan complex(GO:0016012)
0.5 2.6 GO:1990923 PET complex(GO:1990923)
0.4 5.9 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.2 3.9 GO:0046930 pore complex(GO:0046930)
0.1 1.0 GO:0061700 GATOR2 complex(GO:0061700)
0.1 5.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 5.2 GO:0036379 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.1 1.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 1.3 GO:0030057 desmosome(GO:0030057)
0.1 3.1 GO:0005902 microvillus(GO:0005902)
0.1 0.4 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 2.2 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 2.6 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.2 GO:0043596 nuclear replication fork(GO:0043596)
0.0 2.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 1.4 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.5 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.2 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0 1.6 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 4.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.8 GO:0022626 cytosolic ribosome(GO:0022626)
0.0 1.2 GO:0016459 myosin complex(GO:0016459)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.5 GO:0004998 transferrin receptor activity(GO:0004998)
0.8 2.4 GO:0003994 aconitate hydratase activity(GO:0003994)
0.8 3.9 GO:0015288 porin activity(GO:0015288)
0.3 3.7 GO:0035804 structural constituent of egg coat(GO:0035804)
0.3 1.2 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.2 5.2 GO:0005523 tropomyosin binding(GO:0005523)
0.2 5.9 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 3.5 GO:0008308 voltage-gated chloride channel activity(GO:0005247) voltage-gated anion channel activity(GO:0008308)
0.2 1.0 GO:0032190 acrosin binding(GO:0032190)
0.2 3.8 GO:0043236 laminin binding(GO:0043236)
0.2 2.2 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.2 1.6 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.1 1.0 GO:0070728 leucine binding(GO:0070728)
0.1 3.9 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 0.9 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.1 2.2 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 1.9 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.1 1.8 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.1 3.5 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 2.6 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.0 0.4 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.0 1.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 2.6 GO:0005254 chloride channel activity(GO:0005254)
0.0 0.2 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 1.4 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.5 GO:0016251 obsolete general RNA polymerase II transcription factor activity(GO:0016251)
0.0 1.1 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 6.1 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 1.7 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 3.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.9 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 2.4 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 0.1 GO:0000254 C-4 methylsterol oxidase activity(GO:0000254)
0.0 1.0 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.0 3.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.8 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 3.8 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.1 3.9 PID FGF PATHWAY FGF signaling pathway
0.0 1.0 PID CDC42 PATHWAY CDC42 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.9 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 2.4 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 2.5 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 5.9 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.7 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.5 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.2 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation