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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for nkx2.3+nkx2.7

Z-value: 1.20

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Transcription factors associated with nkx2.3+nkx2.7

Gene Symbol Gene ID Gene Info
ENSDARG00000021232 NK2 transcription factor related 7
ENSDARG00000039095 NK2 homeobox 3
ENSDARG00000113490 NK2 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx2.7dr11_v1_chr8_-_50287949_50287949-0.205.6e-02Click!
nkx2.3dr11_v1_chr13_-_40411908_40411917-0.187.9e-02Click!

Activity profile of nkx2.3+nkx2.7 motif

Sorted Z-values of nkx2.3+nkx2.7 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_3828560 17.83 ENSDART00000185273
ENSDART00000179091
glutamate decarboxylase 1b
chr22_-_13851297 14.68 ENSDART00000080306
S100 calcium binding protein, beta (neural)
chr20_+_18551657 14.31 ENSDART00000147001
si:dkeyp-72h1.1
chr13_+_38430466 13.51 ENSDART00000132691
adhesion G protein-coupled receptor B3
chr12_-_25916530 13.25 ENSDART00000186386
synuclein, gamma b (breast cancer-specific protein 1)
chr15_-_15357178 12.81 ENSDART00000106120
3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2
chr20_-_39271844 12.79 ENSDART00000192708
clusterin
chr17_+_23298928 12.27 ENSDART00000153652
zgc:165461
chr4_+_21129752 11.64 ENSDART00000169764
synaptotagmin Ia
chr14_+_29609245 11.41 ENSDART00000043058
si:dkey-34l15.2
chr11_+_7324704 11.21 ENSDART00000031937
DIRAS family, GTP-binding RAS-like 1a
chr24_-_6158933 11.21 ENSDART00000021609
glutamate decarboxylase 2
chr24_+_2519761 10.70 ENSDART00000106619
neuritin 1a
chr12_+_24342303 10.24 ENSDART00000111239
neurexin 1a
chr5_-_58939460 9.80 ENSDART00000122413
melanoma cell adhesion molecule a
chr1_+_45085194 9.78 ENSDART00000193863
si:ch211-151p13.8
chr8_+_24861264 9.31 ENSDART00000099607
solute carrier family 6 (neutral amino acid transporter), member 17
chr7_-_28148310 9.18 ENSDART00000044208
LIM domain only 1
chr17_-_12389259 9.13 ENSDART00000185724
synaptosomal-associated protein, 25b
chr5_+_23622177 9.12 ENSDART00000121504
connexin 27.5
chr8_+_31821396 9.00 ENSDART00000077053
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr21_-_43015383 8.90 ENSDART00000065097
dihydropyrimidinase-like 3
chr11_+_30057762 8.85 ENSDART00000164139
Nance-Horan syndrome b (congenital cataracts and dental anomalies)
chr12_+_34953038 8.79 ENSDART00000187022
ENSDART00000123988
ENSDART00000027034
QKI, KH domain containing, RNA binding 2
chr1_+_40023640 8.75 ENSDART00000101623
leucine-rich repeat LGI family, member 2b
chr20_-_28800999 8.67 ENSDART00000049462
RAB15, member RAS oncogene family
chr18_+_24921587 8.21 ENSDART00000191345
repulsive guidance molecule family member a
chr3_+_29714775 8.05 ENSDART00000041388
calcium channel, voltage-dependent, gamma subunit 2a
chr24_+_34606966 7.70 ENSDART00000105477
leucine rich repeat transmembrane neuronal 2
chr13_+_24834199 7.60 ENSDART00000101274
zgc:153981
chr9_+_40939336 7.57 ENSDART00000100386
myostatin b
chr4_+_12615836 7.55 ENSDART00000003583
LIM domain only 3
chr23_-_14990865 7.42 ENSDART00000147799
ndrg family member 3b
chr16_+_32059785 7.42 ENSDART00000134459
si:dkey-40m6.8
chr3_-_28250722 7.40 ENSDART00000165936
RNA binding fox-1 homolog 1
chr12_+_3022882 7.36 ENSDART00000122905
Rac family small GTPase 3b
chr17_-_6399920 7.35 ENSDART00000022010
human immunodeficiency virus type I enhancer binding protein 2b
chr12_+_5081759 7.28 ENSDART00000164178
proline-rich transmembrane protein 2
chr5_-_10946232 7.14 ENSDART00000163139
ENSDART00000031265
reticulon 4 receptor
chr16_+_20161805 7.14 ENSDART00000192146
chromosome 16 C2orf66 homolog
chr17_-_44247707 7.01 ENSDART00000126097
orthodenticle homeobox 2b
chr15_-_12319065 6.94 ENSDART00000162973
ENSDART00000170543
FXYD domain containing ion transport regulator 6
chr2_+_22702488 6.94 ENSDART00000076647
kinesin family member 1Ab
chr21_+_28958471 6.93 ENSDART00000144331
ENSDART00000005929
protein phosphatase 3, catalytic subunit, alpha isozyme
chr9_-_51323545 6.89 ENSDART00000139316
solute carrier family 4, sodium bicarbonate transporter, member 10b
chr11_-_6188413 6.72 ENSDART00000109972
chemokine (C-C motif) ligand 44
chr7_-_24699985 6.71 ENSDART00000052802
calbindin 2b
chr15_-_6247775 6.51 ENSDART00000148350
Down syndrome cell adhesion molecule b
chr25_-_7683316 6.49 ENSDART00000128820
si:ch211-286c4.6
chr18_+_40381102 6.49 ENSDART00000136588
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like
chr10_-_8033468 6.45 ENSDART00000140476
ATPase H+ transporting V0 subunit a2a
chr22_+_27090136 6.45 ENSDART00000136770
si:dkey-246e1.3
chr22_-_33679277 6.41 ENSDART00000169948

chr16_+_9779680 6.38 ENSDART00000154253
zgc:92912
chr21_+_18353703 6.35 ENSDART00000181396
ENSDART00000166359
si:ch73-287m6.1
chr14_+_25465346 6.32 ENSDART00000173436
si:dkey-280e21.3
chr24_+_22759451 6.18 ENSDART00000135392
si:dkey-7n6.2
chr20_+_34717403 6.15 ENSDART00000034252
prepronociceptin b
chr5_-_14373662 6.12 ENSDART00000183694
tet methylcytosine dioxygenase 3
chr18_+_9637744 6.12 ENSDART00000190171
piccolo presynaptic cytomatrix protein b
chr19_+_24872159 6.11 ENSDART00000158490
si:ch211-195b13.1
chr23_+_28374458 6.10 ENSDART00000140058
ENSDART00000144240
zgc:153867
chr6_-_41229787 6.03 ENSDART00000065013
synaptoporin
chr23_+_44741500 5.98 ENSDART00000166421
ATPase Na+/K+ transporting subunit beta 2a
chr21_+_9628854 5.96 ENSDART00000161753
ENSDART00000160711
mitogen-activated protein kinase 10
chr9_+_21722733 5.92 ENSDART00000102021
SRY (sex determining region Y)-box 1a
chr9_-_1702648 5.86 ENSDART00000102934
heterogeneous nuclear ribonucleoprotein A3
chr25_-_9805269 5.82 ENSDART00000192048
leucine rich repeat containing 4C
chr22_+_18389271 5.78 ENSDART00000088270
YjeF N-terminal domain containing 3
chr15_+_26399538 5.72 ENSDART00000159589
reticulon 4 receptor-like 1b
chr7_+_32722227 5.70 ENSDART00000126565
si:ch211-150g13.3
chr9_-_32753535 5.69 ENSDART00000060006
oligodendrocyte lineage transcription factor 2
chr7_-_26497947 5.64 ENSDART00000058910
SRY (sex determining region Y)-box 19b
chr16_-_55028740 5.62 ENSDART00000156368
ENSDART00000161704
zgc:114181
chr2_+_20332044 5.49 ENSDART00000112131
phospholipid phosphatase related 4a
chr3_-_35800221 5.47 ENSDART00000031390
CASK interacting protein 1
chr15_+_36115955 5.44 ENSDART00000032702
somatostatin 1, tandem duplicate 2
chr2_+_26656283 5.44 ENSDART00000133202
ENSDART00000099208
aspartate beta-hydroxylase
chr9_-_3671911 5.42 ENSDART00000102900
Sp5 transcription factor a
chr12_+_7497882 5.42 ENSDART00000134608
phytanoyl-CoA 2-hydroxylase interacting protein-like b
chr6_-_11780070 5.41 ENSDART00000151195
membrane-associated ring finger (C3HC4) 7
chr5_-_28679135 5.39 ENSDART00000193585
tenascin C
chr19_-_42391383 5.35 ENSDART00000110075
ENSDART00000087002
pleckstrin homology domain containing, family O member 1a
chr24_-_8729531 5.32 ENSDART00000082346
transcription factor AP-2 alpha
chr5_+_32009080 5.25 ENSDART00000186885
suppressor of cancer cell invasion
chr1_-_11973341 5.21 ENSDART00000159981
ENSDART00000066638
G protein-coupled receptor kinase 4
chr19_+_42886413 5.19 ENSDART00000151298
cAMP-regulated phosphoprotein, 21
chr8_-_33114202 5.14 ENSDART00000098840
Ral GEF with PH domain and SH3 binding motif 1
chr1_-_23110740 5.11 ENSDART00000171848
ENSDART00000086797
ENSDART00000189344
ENSDART00000190858
adhesion G protein-coupled receptor L3.1
chr9_-_18735256 5.11 ENSDART00000143165
TSC22 domain family, member 1
chr5_-_31901468 5.10 ENSDART00000147814
ENSDART00000141446
coronin, actin binding protein, 1Cb
chr5_+_36611128 5.09 ENSDART00000097684
neuro-oncological ventral antigen 1
chr10_+_37137464 5.03 ENSDART00000114909
CUE domain containing 1a
chr8_+_3820134 5.03 ENSDART00000122454
citron rho-interacting serine/threonine kinase b
chr19_+_37848830 5.01 ENSDART00000042276
ENSDART00000180872
neurexophilin 1
chr23_+_19590006 4.99 ENSDART00000021231
sarcolemma associated protein b
chr17_+_19630272 4.97 ENSDART00000104895
regulator of G protein signaling 7a
chr19_-_44089509 4.97 ENSDART00000189136
RAD21 cohesin complex component b
chr13_-_14487524 4.88 ENSDART00000141103
GDNF family receptor alpha 4a
chr14_-_24410673 4.87 ENSDART00000125923
chemokine (C-X-C motif) ligand 14
chr1_+_33969015 4.86 ENSDART00000042984
ENSDART00000146530
eph receptor A6
chr3_+_9379877 4.85 ENSDART00000182080

chr21_-_42100471 4.84 ENSDART00000166148
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr19_-_7358184 4.83 ENSDART00000092379
oxidation resistance 1b
chr24_+_41915878 4.81 ENSDART00000171523
transmembrane protein 200C
chr10_+_22381802 4.78 ENSDART00000112484
neuroligin 2b
chr6_-_30210378 4.78 ENSDART00000157359
ENSDART00000113924
leucine rich repeat containing 7
chr21_+_34088110 4.77 ENSDART00000145123
ENSDART00000029599
ENSDART00000147519
myotubularin related protein 1b
chr23_-_7799184 4.76 ENSDART00000190946
ENSDART00000165427
myelin transcription factor 1b
chr1_-_22512063 4.66 ENSDART00000031546
ENSDART00000190987
cholinergic receptor, nicotinic, alpha 6
chr1_-_50859053 4.65 ENSDART00000132779
ENSDART00000137648
si:dkeyp-123h10.2
chr14_-_3381303 4.62 ENSDART00000171601
im:7150988
chr15_-_34213898 4.61 ENSDART00000191945
ENSDART00000186089
ets variant 1
chr15_-_20024205 4.55 ENSDART00000161379
autism susceptibility candidate 2b
chr14_-_2206476 4.55 ENSDART00000081870
protocadherin 2 alpha b 6
chr7_-_28147838 4.54 ENSDART00000158921
LIM domain only 1
chr19_+_1184878 4.53 ENSDART00000163539
scratch family zinc finger 1a
chr13_-_43599898 4.52 ENSDART00000084416
ENSDART00000145705
actin binding LIM protein 1a
chr12_+_39685485 4.50 ENSDART00000163403

chr17_-_42213285 4.49 ENSDART00000140549
NK2 homeobox 2a
chr12_+_18578597 4.48 ENSDART00000134944
glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein, b
chr24_-_8729716 4.45 ENSDART00000183624
transcription factor AP-2 alpha
chr9_+_17983463 4.45 ENSDART00000182150
A kinase (PRKA) anchor protein 11
chr15_-_31514818 4.45 ENSDART00000153978
high mobility group box 1b
chr3_+_60721342 4.42 ENSDART00000157772
forkhead box J1a
chr14_-_4682114 4.41 ENSDART00000014454
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4
chr18_+_10884996 4.40 ENSDART00000147613
microtubule associated monooxygenase, calponin and LIM domain containing 3a
chr10_+_29698467 4.38 ENSDART00000163402
discs, large homolog 2 (Drosophila)
chr8_+_22582146 4.33 ENSDART00000157655
ENSDART00000189892

chr10_-_8032885 4.32 ENSDART00000188619
ATPase H+ transporting V0 subunit a2a
chr9_+_51265283 4.30 ENSDART00000137426
glucagon b
chr13_+_19322686 4.29 ENSDART00000058036
empty spiracles homeobox 2
chr11_-_27501027 4.26 ENSDART00000065889
wingless-type MMTV integration site family, member 7Aa
chr14_+_49135264 4.24 ENSDART00000084119
si:ch1073-44g3.1
chr12_+_21298317 4.23 ENSDART00000178562
carbonic anhydrase Xa
chr6_+_40661703 4.19 ENSDART00000142492
enolase 1b, (alpha)
chr5_+_20147830 4.16 ENSDART00000098727
SV2 related protein a
chr9_+_31534601 4.15 ENSDART00000133094
si:ch211-168k14.2
chr7_+_24023653 4.11 ENSDART00000141165
TERF1 (TRF1)-interacting nuclear factor 2
chr11_+_31323746 4.10 ENSDART00000180220
ENSDART00000189937
signal-induced proliferation-associated 1 like 2
chr19_+_26718074 4.06 ENSDART00000134455
zgc:100906
chr22_+_5176255 4.05 ENSDART00000092647
ceramide synthase 1
chr12_+_33038757 4.01 ENSDART00000153146
RNA binding fox-1 homolog 3a
chr4_+_12111154 3.93 ENSDART00000036779
transmembrane protein 178B
chr9_-_33107237 3.93 ENSDART00000013918
calsequestrin 2
chr8_+_26874924 3.93 ENSDART00000141794
ribosomal modification protein rimK-like family member A
chr24_+_25069609 3.82 ENSDART00000115165
APC membrane recruitment protein 2
chr21_+_22404662 3.80 ENSDART00000183455
LMBR1 domain containing 2b
chr16_-_29480335 3.78 ENSDART00000148930
leucine rich repeat and Ig domain containing 4b
chr16_+_39159752 3.75 ENSDART00000122081
syntabulin (syntaxin-interacting)
chr12_+_15008582 3.73 ENSDART00000003847
myosin light chain, phosphorylatable, fast skeletal muscle b
chr13_+_24662238 3.73 ENSDART00000014176
muscle segment homeobox 3
chr5_-_12407194 3.72 ENSDART00000125291
kinase suppressor of ras 2
chr18_-_41375120 3.71 ENSDART00000098673
pentraxin 3, long a
chr12_-_8958353 3.66 ENSDART00000041728
cytochrome P450, family 26, subfamily A, polypeptide 1
chr19_+_20178978 3.63 ENSDART00000145115
ENSDART00000151175
transformer 2 alpha homolog
chr8_-_9570511 3.58 ENSDART00000044000
plexin A3
chr25_+_14165447 3.55 ENSDART00000145387
SH3 and multiple ankyrin repeat domains 2
chr19_-_28789404 3.54 ENSDART00000191453
ENSDART00000026992
SRY (sex determining region Y)-box 4a
chr6_+_52350443 3.50 ENSDART00000151612
ENSDART00000151349
si:ch211-239j9.1
chr3_-_30061985 3.47 ENSDART00000189583
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr18_+_11970987 3.45 ENSDART00000144111
si:dkeyp-2c8.3
chr14_-_33894915 3.43 ENSDART00000143290
urotensin-related peptide 1
chr1_+_7517454 3.39 ENSDART00000016139
LanC antibiotic synthetase component C-like 1 (bacterial)
chr19_+_9459050 3.39 ENSDART00000186419
si:ch211-288g17.3
chr14_+_36628131 3.36 ENSDART00000188625
ENSDART00000125345
si:dkey-237h12.3
chr6_+_37623693 3.34 ENSDART00000144812
ENSDART00000182709
tubulin, gamma complex associated protein 5
chr6_+_21001264 3.33 ENSDART00000044519
ENSDART00000151278
connexin 44.2
chr8_-_19467011 3.31 ENSDART00000162010
zgc:92140
chr23_+_37458602 3.27 ENSDART00000181686
cytidine deaminase a
chr24_+_26039464 3.27 ENSDART00000131017
tyrosine kinase, non-receptor, 2a
chr13_+_38990939 3.26 ENSDART00000145979
collagen, type XIX, alpha 1
chr2_+_39108339 3.25 ENSDART00000085675
calsyntenin 2
chr8_-_50888806 3.21 ENSDART00000053750
acyl-CoA synthetase long chain family member 2
chr11_+_30244356 3.20 ENSDART00000036050
ENSDART00000150080
retinoschisin 1a
chr5_+_32206378 3.20 ENSDART00000126873
ENSDART00000051361
myosin, heavy polypeptide 2, fast muscle specific
chr20_-_23171430 3.13 ENSDART00000109234
spermatogenesis associated 18
chr14_+_3449780 3.11 ENSDART00000163849
transient receptor potential cation channel, subfamily C, member 3
chr16_-_13680692 3.11 ENSDART00000047452
ubiquitin-conjugating enzyme E2S
chr16_+_46459680 3.11 ENSDART00000101698
rapunzel 3
chr22_-_3564563 3.10 ENSDART00000145114
protein tyrosine phosphatase, receptor type, s, a
chr19_+_13099541 3.10 ENSDART00000171607
ENSDART00000165448
ENSDART00000170365
regulating synaptic membrane exocytosis 2b
chr8_-_19051906 3.09 ENSDART00000089024
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Bb
chr14_-_2203124 3.08 ENSDART00000124171
si:dkeyp-115d7.2
chr20_-_35052823 3.08 ENSDART00000153033
kinesin family member 26Bb
chr24_+_11334733 3.08 ENSDART00000147552
ENSDART00000143171
si:dkey-12l12.1
chr2_+_30786773 3.08 ENSDART00000019029
ENSDART00000145681
ATPase H+ transporting V1 subunit H
chr1_-_13271569 3.05 ENSDART00000127838
protocadherin 18a
chr1_-_13271085 3.02 ENSDART00000193663
protocadherin 18a
chr11_+_44804685 3.02 ENSDART00000163660
striatin, calmodulin binding protein
chr17_-_14700889 3.01 ENSDART00000179975
protein tyrosine phosphatase type IVA, member 2a
chr21_+_28478663 2.95 ENSDART00000077887
ENSDART00000134150
solute carrier family 22 (organic anion transporter), member 6, like
chr10_+_33744098 2.94 ENSDART00000147775
relaxin/insulin-like family peptide receptor 2a
chr7_+_73397283 2.85 ENSDART00000174390

chr10_+_42690374 2.83 ENSDART00000123496
Rho-related BTB domain containing 2b
chr5_-_67145505 2.83 ENSDART00000011295
retinal outer segment membrane protein 1a
chr2_-_32352946 2.82 ENSDART00000144870
ENSDART00000077151
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1a
chr20_-_47732703 2.80 ENSDART00000193975
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr17_-_3986236 2.78 ENSDART00000188794
ENSDART00000160830
si:ch1073-140o9.2
chr5_+_32009542 2.75 ENSDART00000182025
ENSDART00000179879
suppressor of cancer cell invasion

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx2.3+nkx2.7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
9.7 29.0 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
3.1 9.3 GO:0015824 proline transport(GO:0015824)
2.7 13.5 GO:0016322 neuron remodeling(GO:0016322)
2.2 11.2 GO:0061551 trigeminal ganglion development(GO:0061551)
2.1 6.2 GO:0021530 spinal cord oligodendrocyte cell fate specification(GO:0021530)
1.9 7.6 GO:0045843 negative regulation of striated muscle tissue development(GO:0045843) negative regulation of muscle tissue development(GO:1901862)
1.8 5.4 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582) axon regeneration at neuromuscular junction(GO:0014814) positive regulation of synaptic growth at neuromuscular junction(GO:0045887)
1.7 6.7 GO:1900271 regulation of presynaptic cytosolic calcium ion concentration(GO:0099509) regulation of long-term synaptic potentiation(GO:1900271)
1.6 8.2 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
1.4 5.8 GO:0010874 regulation of cholesterol efflux(GO:0010874)
1.4 5.7 GO:0021742 abducens nucleus development(GO:0021742)
1.3 5.2 GO:0044068 modification by symbiont of host morphology or physiology(GO:0044003) modulation by symbiont of host cellular process(GO:0044068)
1.3 6.3 GO:0016103 diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
1.2 4.8 GO:0003322 pancreatic A cell development(GO:0003322)
1.1 5.5 GO:0032656 interleukin-13 production(GO:0032616) regulation of interleukin-13 production(GO:0032656)
1.1 3.3 GO:0009972 cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
1.1 5.4 GO:0042264 peptidyl-aspartic acid modification(GO:0018197) peptidyl-aspartic acid hydroxylation(GO:0042264)
1.1 4.2 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
1.0 4.8 GO:0070208 protein heterotrimerization(GO:0070208)
0.9 3.7 GO:0060074 synapse maturation(GO:0060074)
0.9 5.6 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.9 2.7 GO:0048917 posterior lateral line ganglion development(GO:0048917)
0.9 4.4 GO:0060296 regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.8 5.5 GO:0048069 eye pigmentation(GO:0048069)
0.8 10.8 GO:0007035 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.8 16.6 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.7 8.9 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.7 3.6 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.7 6.1 GO:0060118 vestibular receptor cell differentiation(GO:0060114) vestibular receptor cell development(GO:0060118)
0.7 2.0 GO:0010863 positive regulation of phospholipase C activity(GO:0010863) regulation of phospholipase C activity(GO:1900274)
0.6 9.1 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.6 8.2 GO:0014036 neural crest cell fate commitment(GO:0014034) neural crest cell fate specification(GO:0014036)
0.6 10.2 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.6 2.3 GO:1902260 negative regulation of potassium ion transmembrane transporter activity(GO:1901017) negative regulation of potassium ion transmembrane transport(GO:1901380) negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.6 13.9 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.5 4.4 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
0.5 7.5 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.5 3.1 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.5 5.0 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.5 5.0 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.5 1.9 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.5 7.0 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.5 6.9 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.5 6.4 GO:0035493 SNARE complex assembly(GO:0035493)
0.4 7.1 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.4 1.3 GO:1903673 mitotic cytokinetic process(GO:1902410) mitotic cleavage furrow formation(GO:1903673)
0.4 7.4 GO:0021654 rhombomere boundary formation(GO:0021654)
0.4 2.0 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.4 2.7 GO:0070206 protein trimerization(GO:0070206) protein homotrimerization(GO:0070207)
0.4 2.2 GO:0021634 optic nerve formation(GO:0021634)
0.3 1.7 GO:0000012 single strand break repair(GO:0000012)
0.3 2.4 GO:0018344 protein geranylgeranylation(GO:0018344)
0.3 6.2 GO:0032204 regulation of telomere maintenance(GO:0032204)
0.3 1.9 GO:0060823 canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060823) regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827)
0.3 6.0 GO:0071436 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.3 1.2 GO:0043461 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.3 6.9 GO:0015701 bicarbonate transport(GO:0015701)
0.3 3.2 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.3 6.3 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.3 2.0 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.3 17.2 GO:0050919 negative chemotaxis(GO:0050919)
0.3 2.2 GO:0043584 nose development(GO:0043584)
0.3 1.9 GO:0030728 ovulation(GO:0030728)
0.3 1.6 GO:0097250 mitochondrial respiratory chain supercomplex assembly(GO:0097250)
0.3 8.7 GO:0032482 Rab protein signal transduction(GO:0032482)
0.3 1.1 GO:0042754 negative regulation of circadian rhythm(GO:0042754)
0.3 1.3 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.3 1.0 GO:0010259 multicellular organism aging(GO:0010259)
0.3 4.4 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.3 1.5 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.2 1.2 GO:1901841 regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.2 2.9 GO:0030816 activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762)
0.2 4.4 GO:0051932 synaptic transmission, GABAergic(GO:0051932)
0.2 0.7 GO:0015871 choline transport(GO:0015871)
0.2 3.4 GO:0007398 ectoderm development(GO:0007398)
0.2 29.3 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)
0.2 4.1 GO:0046473 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.2 9.8 GO:0071696 ectodermal placode development(GO:0071696)
0.2 0.7 GO:0055109 invagination involved in gastrulation with mouth forming second(GO:0055109) morphogenesis of an epithelial fold(GO:0060571)
0.2 3.1 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481) negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.2 3.1 GO:0021772 olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988)
0.2 10.6 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.2 10.8 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.2 2.4 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.2 1.1 GO:0072575 hepatocyte proliferation(GO:0072574) epithelial cell proliferation involved in liver morphogenesis(GO:0072575)
0.2 6.0 GO:0070593 dendrite self-avoidance(GO:0070593)
0.2 4.5 GO:0030032 lamellipodium assembly(GO:0030032)
0.2 1.0 GO:0050938 regulation of xanthophore differentiation(GO:0050938)
0.2 0.6 GO:0021523 somatic motor neuron differentiation(GO:0021523)
0.2 10.7 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.2 6.1 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2 1.1 GO:0070650 actin filament bundle distribution(GO:0070650)
0.2 1.5 GO:0031113 regulation of microtubule polymerization(GO:0031113)
0.2 1.4 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.2 0.5 GO:0043416 regulation of skeletal muscle tissue regeneration(GO:0043416)
0.2 0.9 GO:2001106 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.2 1.3 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.2 10.2 GO:0007254 JNK cascade(GO:0007254)
0.2 9.0 GO:1901214 regulation of neuron death(GO:1901214)
0.2 3.3 GO:0007020 microtubule nucleation(GO:0007020)
0.1 0.7 GO:0007624 ultradian rhythm(GO:0007624)
0.1 1.0 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.1 6.3 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.1 1.6 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.1 0.7 GO:0010586 miRNA metabolic process(GO:0010586)
0.1 1.0 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.1 0.7 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.1 3.2 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.1 3.8 GO:0048935 peripheral nervous system neuron development(GO:0048935)
0.1 3.8 GO:0071875 adrenergic receptor signaling pathway(GO:0071875)
0.1 1.2 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 0.7 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.1 9.2 GO:0019722 calcium-mediated signaling(GO:0019722)
0.1 0.8 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.1 1.7 GO:0051402 neuron apoptotic process(GO:0051402)
0.1 2.3 GO:1902287 semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.1 9.6 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.1 2.4 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 1.2 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.1 11.4 GO:0007224 smoothened signaling pathway(GO:0007224)
0.1 6.6 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.1 2.7 GO:0039020 pronephric nephron tubule development(GO:0039020)
0.1 1.9 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.1 1.8 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.1 1.0 GO:0033198 response to ATP(GO:0033198)
0.1 0.6 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.1 3.2 GO:0043652 engulfment of apoptotic cell(GO:0043652)
0.1 1.5 GO:0006265 DNA topological change(GO:0006265)
0.1 0.8 GO:0043490 acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.1 3.9 GO:0036269 swimming behavior(GO:0036269)
0.1 14.7 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.1 2.0 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 2.0 GO:0090148 membrane fission(GO:0090148)
0.1 2.2 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.1 0.4 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.1 0.7 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.1 2.1 GO:0048846 axon extension involved in axon guidance(GO:0048846) neuron projection extension involved in neuron projection guidance(GO:1902284)
0.1 2.1 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.1 2.6 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.1 1.7 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.1 0.9 GO:0014823 response to activity(GO:0014823)
0.0 7.7 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)
0.0 2.1 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.0 1.4 GO:0010669 epithelial structure maintenance(GO:0010669)
0.0 0.3 GO:0097477 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.0 0.8 GO:0060021 palate development(GO:0060021)
0.0 0.2 GO:0097066 response to thyroid hormone(GO:0097066)
0.0 0.6 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.4 GO:0051877 pigment granule aggregation in cell center(GO:0051877)
0.0 3.6 GO:0007626 locomotory behavior(GO:0007626)
0.0 2.1 GO:0006096 glycolytic process(GO:0006096)
0.0 0.9 GO:0048920 posterior lateral line neuromast primordium migration(GO:0048920)
0.0 0.2 GO:0048923 posterior lateral line neuromast hair cell differentiation(GO:0048923)
0.0 2.2 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 3.8 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 3.5 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.0 1.2 GO:0050684 regulation of mRNA processing(GO:0050684)
0.0 3.7 GO:0006979 response to oxidative stress(GO:0006979)
0.0 1.6 GO:0048332 mesoderm morphogenesis(GO:0048332)
0.0 0.1 GO:0048730 epidermis morphogenesis(GO:0048730)
0.0 1.0 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.1 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.0 1.3 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.1 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 8.1 GO:0016311 dephosphorylation(GO:0016311)
0.0 0.4 GO:0006801 superoxide metabolic process(GO:0006801)
0.0 4.1 GO:0033674 positive regulation of kinase activity(GO:0033674)
0.0 4.1 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 1.7 GO:0030042 actin filament depolymerization(GO:0030042)
0.0 4.0 GO:0030334 regulation of cell migration(GO:0030334)
0.0 0.2 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 2.1 GO:0002040 sprouting angiogenesis(GO:0002040)
0.0 0.7 GO:0003009 skeletal muscle contraction(GO:0003009) multicellular organismal movement(GO:0050879) musculoskeletal movement(GO:0050881)
0.0 0.4 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.1 GO:0051443 positive regulation of ubiquitin-protein transferase activity(GO:0051443)
0.0 0.1 GO:0008105 asymmetric protein localization(GO:0008105) apical protein localization(GO:0045176)
0.0 0.9 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.0 0.3 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.0 0.5 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.4 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 1.2 GO:0006936 muscle contraction(GO:0006936)
0.0 0.2 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 2.1 GO:0007018 microtubule-based movement(GO:0007018)
0.0 0.7 GO:0034968 histone lysine methylation(GO:0034968)
0.0 2.0 GO:0042391 regulation of membrane potential(GO:0042391)
0.0 0.7 GO:0042594 response to starvation(GO:0042594)
0.0 0.1 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.2 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.2 GO:0090307 mitotic spindle assembly(GO:0090307) microtubule cytoskeleton organization involved in mitosis(GO:1902850)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 24.4 GO:0042583 chromaffin granule(GO:0042583)
2.3 13.5 GO:0043083 synaptic cleft(GO:0043083)
1.6 4.8 GO:0060077 inhibitory synapse(GO:0060077)
1.5 9.1 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
1.2 6.9 GO:0005955 calcineurin complex(GO:0005955)
1.1 10.8 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.8 3.3 GO:0008274 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.8 8.1 GO:0032593 insulin-responsive compartment(GO:0032593)
0.8 5.5 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.7 5.0 GO:0030892 nuclear cohesin complex(GO:0000798) mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990) nuclear meiotic cohesin complex(GO:0034991)
0.7 26.1 GO:0043679 axon terminus(GO:0043679)
0.6 6.0 GO:0090533 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.6 2.4 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.6 3.9 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.5 4.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.5 5.0 GO:0098982 GABA-ergic synapse(GO:0098982)
0.5 1.9 GO:0097268 cytoophidium(GO:0097268)
0.5 7.2 GO:0036038 MKS complex(GO:0036038)
0.4 10.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.4 2.0 GO:0045273 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.3 1.8 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.3 1.7 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.3 1.1 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.3 5.8 GO:0002116 semaphorin receptor complex(GO:0002116)
0.3 14.6 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.3 4.1 GO:0070187 telosome(GO:0070187)
0.3 0.8 GO:0005828 kinetochore microtubule(GO:0005828)
0.3 9.3 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.3 1.9 GO:0030897 HOPS complex(GO:0030897)
0.3 5.0 GO:0048788 cytoskeleton of presynaptic active zone(GO:0048788) presynaptic active zone cytoplasmic component(GO:0098831)
0.3 10.1 GO:0031225 anchored component of membrane(GO:0031225)
0.2 2.0 GO:0035060 brahma complex(GO:0035060)
0.2 3.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.2 2.3 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.2 2.1 GO:0071564 npBAF complex(GO:0071564)
0.2 14.8 GO:0005871 kinesin complex(GO:0005871)
0.2 8.9 GO:0030426 growth cone(GO:0030426)
0.1 1.2 GO:0035032 extrinsic component of vacuolar membrane(GO:0000306) phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.1 1.0 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.1 3.3 GO:0048786 presynaptic active zone(GO:0048786)
0.1 1.5 GO:0036449 microtubule minus-end(GO:0036449)
0.1 1.8 GO:0048179 activin receptor complex(GO:0048179)
0.1 3.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 1.0 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.1 1.0 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 3.1 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 2.0 GO:0033176 proton-transporting V-type ATPase complex(GO:0033176)
0.1 11.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 1.8 GO:0005682 U5 snRNP(GO:0005682)
0.1 0.5 GO:0030314 junctional membrane complex(GO:0030314)
0.1 2.1 GO:0071011 precatalytic spliceosome(GO:0071011)
0.1 6.0 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 7.7 GO:0008021 synaptic vesicle(GO:0008021)
0.1 6.4 GO:0031201 SNARE complex(GO:0031201)
0.1 2.1 GO:0005844 polysome(GO:0005844)
0.1 1.0 GO:0000815 ESCRT III complex(GO:0000815)
0.1 0.8 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 13.5 GO:0030424 axon(GO:0030424)
0.1 0.5 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 1.4 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 8.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 1.0 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0 0.5 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 1.8 GO:0016605 PML body(GO:0016605)
0.0 1.3 GO:0005940 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 16.7 GO:0043005 neuron projection(GO:0043005)
0.0 2.2 GO:0016592 mediator complex(GO:0016592)
0.0 0.6 GO:0030008 TRAPP complex(GO:0030008)
0.0 1.6 GO:0016342 catenin complex(GO:0016342)
0.0 0.2 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.7 GO:0030496 midbody(GO:0030496)
0.0 0.5 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 1.5 GO:0005581 collagen trimer(GO:0005581)
0.0 4.4 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 1.3 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.8 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 0.1 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024) nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908)
0.0 0.4 GO:0000145 exocyst(GO:0000145)
0.0 1.6 GO:0016459 myosin complex(GO:0016459)
0.0 0.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.7 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
9.7 29.0 GO:0004351 glutamate decarboxylase activity(GO:0004351)
4.4 13.3 GO:1903136 cuprous ion binding(GO:1903136)
3.7 14.7 GO:0044548 S100 protein binding(GO:0044548)
2.1 6.3 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
1.4 5.4 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
1.3 3.9 GO:0072591 N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590) citrate-L-glutamate ligase activity(GO:0072591)
1.2 6.9 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
1.0 5.9 GO:0008158 hedgehog receptor activity(GO:0008158)
0.9 5.6 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.9 4.3 GO:0031769 glucagon receptor binding(GO:0031769)
0.8 13.6 GO:0048495 Roundabout binding(GO:0048495)
0.8 3.3 GO:0051059 NF-kappaB binding(GO:0051059)
0.8 5.5 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.7 8.9 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.7 10.8 GO:0051117 ATPase binding(GO:0051117)
0.7 3.4 GO:0043295 glutathione binding(GO:0043295)
0.7 2.0 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.7 9.3 GO:0022851 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.6 25.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.6 6.0 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.6 2.4 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.6 4.1 GO:0004630 phospholipase D activity(GO:0004630)
0.6 5.6 GO:0016805 dipeptidase activity(GO:0016805)
0.5 4.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.5 2.7 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.5 3.0 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.5 6.9 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.5 1.9 GO:0003883 CTP synthase activity(GO:0003883)
0.5 4.8 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.5 6.1 GO:0031628 opioid receptor binding(GO:0031628)
0.5 3.3 GO:0004126 cytidine deaminase activity(GO:0004126)
0.5 12.5 GO:0051787 misfolded protein binding(GO:0051787)
0.4 6.6 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.4 8.2 GO:0015026 coreceptor activity(GO:0015026)
0.4 7.5 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.4 10.9 GO:0017080 sodium channel regulator activity(GO:0017080)
0.4 2.1 GO:0004743 pyruvate kinase activity(GO:0004743)
0.3 2.4 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.3 5.2 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.3 1.9 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.3 4.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.3 11.2 GO:0019003 GDP binding(GO:0019003)
0.3 6.0 GO:0001671 ATPase activator activity(GO:0001671)
0.3 3.2 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.3 9.6 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.3 2.0 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.3 1.1 GO:0071889 14-3-3 protein binding(GO:0071889)
0.3 5.0 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.3 5.8 GO:0016854 racemase and epimerase activity(GO:0016854)
0.2 1.7 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.2 2.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2 11.6 GO:0001786 phosphatidylserine binding(GO:0001786)
0.2 1.7 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.2 4.4 GO:0008301 DNA binding, bending(GO:0008301)
0.2 3.7 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 18.3 GO:0016247 channel regulator activity(GO:0016247)
0.2 3.1 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.2 3.2 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.2 5.5 GO:0042577 lipid phosphatase activity(GO:0042577)
0.2 1.5 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.2 3.4 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.2 1.2 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.2 0.4 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.2 5.8 GO:0017154 semaphorin receptor activity(GO:0017154)
0.2 0.7 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.2 1.1 GO:0032052 bile acid binding(GO:0032052)
0.2 11.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 6.0 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.2 11.1 GO:0008009 chemokine activity(GO:0008009)
0.2 4.5 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.2 7.0 GO:0044325 ion channel binding(GO:0044325)
0.2 3.8 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.2 3.6 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 1.2 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.1 11.4 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 4.4 GO:0051018 protein kinase A binding(GO:0051018)
0.1 4.1 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 7.8 GO:0017124 SH3 domain binding(GO:0017124)
0.1 2.8 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 1.5 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.1 1.8 GO:0017002 activin-activated receptor activity(GO:0017002)
0.1 1.5 GO:0051011 microtubule minus-end binding(GO:0051011)
0.1 2.0 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 4.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 0.6 GO:0016880 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.1 0.8 GO:0043515 kinetochore binding(GO:0043515)
0.1 3.8 GO:0008013 beta-catenin binding(GO:0008013)
0.1 1.0 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 3.3 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 0.7 GO:0008263 mismatch base pair DNA N-glycosylase activity(GO:0000700) pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
0.1 4.4 GO:0071949 FAD binding(GO:0071949)
0.1 2.8 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 0.4 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.1 0.7 GO:0035198 miRNA binding(GO:0035198)
0.1 0.8 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.1 2.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 1.5 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 10.0 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 9.0 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.1 21.1 GO:0003924 GTPase activity(GO:0003924)
0.0 0.7 GO:0002039 p53 binding(GO:0002039)
0.0 1.7 GO:0003684 damaged DNA binding(GO:0003684)
0.0 1.0 GO:0000339 RNA cap binding(GO:0000339)
0.0 14.5 GO:0005096 GTPase activator activity(GO:0005096)
0.0 7.0 GO:0015293 symporter activity(GO:0015293)
0.0 0.8 GO:0031267 small GTPase binding(GO:0031267)
0.0 0.5 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 11.1 GO:0051015 actin filament binding(GO:0051015)
0.0 1.7 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.4 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 3.8 GO:0008083 growth factor activity(GO:0008083)
0.0 2.1 GO:0003777 microtubule motor activity(GO:0003777)
0.0 3.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.6 GO:0030165 PDZ domain binding(GO:0030165)
0.0 3.3 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 2.6 GO:0005179 hormone activity(GO:0005179)
0.0 0.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.2 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.2 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 2.9 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.0 0.1 GO:0030619 U1 snRNA binding(GO:0030619)
0.0 0.4 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 1.9 GO:0005262 calcium channel activity(GO:0005262)
0.0 0.1 GO:0030332 cyclin binding(GO:0030332)
0.0 0.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 3.8 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 6.4 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.4 10.7 PID RHOA PATHWAY RhoA signaling pathway
0.3 5.4 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.3 4.6 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.3 6.0 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.3 13.6 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.2 11.3 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.2 3.1 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.2 2.8 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.2 2.9 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.2 4.9 PID EPHA FWDPATHWAY EPHA forward signaling
0.2 6.2 PID BMP PATHWAY BMP receptor signaling
0.2 3.0 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.1 0.7 PID GLYPICAN 1PATHWAY Glypican 1 network
0.1 2.2 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 7.1 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.1 2.2 PID AP1 PATHWAY AP-1 transcription factor network
0.1 3.2 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 0.4 PID ALK2 PATHWAY ALK2 signaling events
0.1 4.1 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 12.1 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 1.2 PID CONE PATHWAY Visual signal transduction: Cones
0.1 1.2 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 2.1 PID FGF PATHWAY FGF signaling pathway
0.1 1.7 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 1.3 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 3.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.4 PID AURORA B PATHWAY Aurora B signaling
0.0 0.3 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.0 0.4 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.8 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.4 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.9 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.3 PID ARF 3PATHWAY Arf1 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 14.7 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
1.1 12.5 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.8 11.2 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.8 3.1 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.7 6.0 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.7 7.5 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.6 9.3 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.5 4.7 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.4 6.9 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.3 10.7 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.3 2.8 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.3 2.7 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.3 3.3 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.3 2.1 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.3 4.1 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.2 1.9 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.2 3.6 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.2 1.7 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 3.2 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 0.7 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 2.6 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 1.7 REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.1 2.2 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 1.0 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 2.1 REACTOME KINESINS Genes involved in Kinesins
0.1 4.5 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.0 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 1.0 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 0.2 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.0 0.7 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.4 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 4.5 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 1.3 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 5.5 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.9 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.4 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.5 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 2.5 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.4 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.3 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.4 REACTOME RNA POL I TRANSCRIPTION INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.0 0.8 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.3 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.1 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane