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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for nkx2.5

Z-value: 0.70

Motif logo

Transcription factors associated with nkx2.5

Gene Symbol Gene ID Gene Info
ENSDARG00000018004 NK2 homeobox 5
ENSDARG00000116714 NK2 homeobox 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx2.5dr11_v1_chr14_+_24241241_242412410.533.2e-08Click!

Activity profile of nkx2.5 motif

Sorted Z-values of nkx2.5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_48609521 5.90 ENSDART00000060765
natriuretic peptide B
chr4_-_4119396 4.83 ENSDART00000067409
ENSDART00000138221
leiomodin 2 (cardiac) b
chr12_-_26423439 4.34 ENSDART00000113978
synaptopodin 2-like b
chr9_+_30475563 4.32 ENSDART00000133118
gap junction protein, alpha 5a
chr7_-_16562200 4.17 ENSDART00000169093
ENSDART00000173491
cysteine and glycine-rich protein 3 (cardiac LIM protein)
chr13_+_28702104 4.02 ENSDART00000135481
si:ch211-67n3.9
chr25_-_28674739 3.70 ENSDART00000067073
leucine rich repeat containing 10
chrM_+_4993 3.69 ENSDART00000093600
NADH dehydrogenase 2, mitochondrial
chr19_-_28360033 3.20 ENSDART00000186994
si:dkey-261i16.5
chr16_-_17200120 2.95 ENSDART00000147739
glyceraldehyde-3-phosphate dehydrogenase
chr6_+_24817852 2.50 ENSDART00000165609
BarH-like homeobox 2
chr20_-_53996193 2.29 ENSDART00000004756
heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1
chr2_+_55916911 2.27 ENSDART00000189483
ENSDART00000183647
ENSDART00000083470
ataxia, cerebellar, Cayman type b
chr20_-_28642061 2.23 ENSDART00000135513
regulator of G protein signaling 6
chr10_-_39153959 2.18 ENSDART00000150193
ENSDART00000111362
solute carrier family 37 (glucose-6-phosphate transporter), member 4b
chr20_-_25671342 2.09 ENSDART00000182775
si:dkeyp-117h8.2
chr19_-_3261019 2.06 ENSDART00000134407
si:ch211-133n4.12
chr11_-_12634017 2.02 ENSDART00000158286
ENSDART00000193090

chr5_+_31944270 1.98 ENSDART00000147850
uracil DNA glycosylase b
chr23_-_35756115 1.98 ENSDART00000043429
junctophilin 2
chr11_-_29082175 1.94 ENSDART00000123245
immunoglobin superfamily, member 21a
chr11_-_29082429 1.91 ENSDART00000041443
immunoglobin superfamily, member 21a
chr23_-_24856025 1.88 ENSDART00000142171
synaptotagmin VIa
chr20_+_50956369 1.85 ENSDART00000170854
gephyrin b
chr11_-_8782871 1.84 ENSDART00000158546
si:ch211-51h4.2
chr15_-_17138640 1.84 ENSDART00000080777
mitochondrial ribosomal protein L28
chr1_+_34243650 1.83 ENSDART00000147201
solute carrier family 5 (sodium/choline cotransporter), member 7a
chr13_-_6218248 1.81 ENSDART00000159052
si:zfos-1056e6.1
chr22_+_18389271 1.78 ENSDART00000088270
YjeF N-terminal domain containing 3
chr22_-_19552796 1.77 ENSDART00000148088
ENSDART00000105485
si:dkey-78l4.14
chr4_-_4795205 1.73 ENSDART00000039313
zgc:162331
chr15_-_47937204 1.72 ENSDART00000154705
si:ch1073-111c8.3
chr23_+_2778813 1.68 ENSDART00000142621
DNA topoisomerase I
chr1_-_45633955 1.66 ENSDART00000044057
septin 3
chr3_+_19207176 1.66 ENSDART00000087803
relaxin 3a
chr9_-_34944604 1.65 ENSDART00000140563
ENSDART00000136812
DCN1, defective in cullin neddylation 1, domain containing 2a
chr20_+_23498255 1.61 ENSDART00000149922
palladin, cytoskeletal associated protein
chr11_-_12452482 1.59 ENSDART00000159554
zgc:174354
chr9_+_17862858 1.58 ENSDART00000166566
diacylglycerol kinase, eta
chr21_-_25484990 1.58 ENSDART00000180289
connector enhancer of kinase suppressor of Ras 2b
chr17_+_30205258 1.53 ENSDART00000076596
ENSDART00000153795
spermatogenesis associated 17
chr12_+_26706745 1.48 ENSDART00000141401
Rho GTPase activating protein 12b
chr14_-_32255126 1.46 ENSDART00000017259
fibroblast growth factor 13a
chr6_+_27304503 1.46 ENSDART00000154759
espin like a
chr16_+_13993285 1.36 ENSDART00000139130
ENSDART00000130353
si:dkey-85k15.7
farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)
chr7_-_32833153 1.32 ENSDART00000099871
ENSDART00000099872
solute carrier family 17 (vesicular glutamate transporter), member 6b
chr6_+_374875 1.32 ENSDART00000171698
si:zfos-169g10.3
chr19_-_6873107 1.32 ENSDART00000124440

chr14_+_23874062 1.31 ENSDART00000172149
SH3 domain containing ring finger 2
chr11_-_12363941 1.30 ENSDART00000192304
zgc:174353
chr12_-_19862912 1.30 ENSDART00000145788
shisa family member 9a
chr6_-_29195642 1.29 ENSDART00000078625
dermatopontin
chr22_+_25236888 1.29 ENSDART00000037286
zgc:172218
chr11_-_12379541 1.28 ENSDART00000171717
zgc:174353
chr13_-_37620091 1.25 ENSDART00000135875
ENSDART00000193270
ENSDART00000018064
zgc:152791
chr21_+_31434251 1.25 ENSDART00000040740
ENSDART00000130157
si:ch211-12m10.1
si:ch211-166i24.1
chr6_-_10168822 1.22 ENSDART00000151016
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1a
chr8_+_30921403 1.21 ENSDART00000043251
derlin 3
chr20_-_42102416 1.20 ENSDART00000186378
ENSDART00000188253
ENSDART00000186458
solute carrier family 35, member F1
chr2_+_27010439 1.18 ENSDART00000030547
cadherin 7a
chr17_+_25955003 1.17 ENSDART00000156029
glutamate receptor, ionotropic, delta 1a
chr5_-_31712399 1.15 ENSDART00000141328
phosphatidylinositol-4-phosphate 5-kinase-like 1
chr17_-_30205302 1.15 ENSDART00000156827
si:dkey-27l15.1
chr24_+_10039165 1.12 ENSDART00000144186
POU class 6 homeobox 2
chr17_+_13088594 1.12 ENSDART00000193207
gem (nuclear organelle) associated protein 2
chr25_+_36152215 1.11 ENSDART00000036147
iroquois homeobox 5b
chr7_-_23971497 1.08 ENSDART00000173603
si:dkey-183c6.8
chr14_+_11762991 1.08 ENSDART00000110004
FERM and PDZ domain containing 3
chr6_-_7726849 1.08 ENSDART00000151511
solute carrier family 25, member 38b
chr7_-_40122139 1.07 ENSDART00000173982
si:ch73-174h16.5
chr11_-_12417952 1.06 ENSDART00000135694
si:dkey-27d5.9
chr3_-_5664123 1.06 ENSDART00000145866
si:ch211-106h11.1
chr12_+_44610912 1.06 ENSDART00000179030
ENSDART00000178008
family with sequence similarity 196 member A
chr5_-_29122615 1.06 ENSDART00000144802
whirlin b
chr12_-_1694053 1.03 ENSDART00000169370

chr14_-_2267515 1.02 ENSDART00000180988
ENSDART00000130712
protocadherin 2 alpha a 15
chr10_-_24371312 1.01 ENSDART00000149362
phosphatidylinositol transfer protein, alpha b
chr8_-_13823091 0.99 ENSDART00000177174
ENSDART00000137021
calcium binding protein 4
chr24_-_11057305 0.98 ENSDART00000186494
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1b
chr14_+_31493119 0.98 ENSDART00000006463
PHD finger protein 6
chr3_+_14463941 0.97 ENSDART00000170927
calponin 1, basic, smooth muscle, b
chr3_-_7170661 0.97 ENSDART00000190345

chr11_-_12379359 0.97 ENSDART00000187551
zgc:174353
chr3_-_13599482 0.97 ENSDART00000166639
Tu translation elongation factor, mitochondrial
chr9_+_2452672 0.96 ENSDART00000193993
chimerin 1
chr11_-_12334546 0.95 ENSDART00000127768
zgc:91850
chr10_-_34867401 0.93 ENSDART00000145545
doublecortin-like kinase 1a
chr13_-_28610965 0.93 ENSDART00000043156
cytochrome P450, family 17, subfamily A, polypeptide 1
chr6_+_515181 0.93 ENSDART00000171374
si:ch73-379f7.5
chr6_+_55285578 0.93 ENSDART00000180183
zgc:109913
chr22_-_30881738 0.91 ENSDART00000059965
si:dkey-49n23.1
chr24_+_1294176 0.90 ENSDART00000106637
si:ch73-134f24.1
chr17_-_16342388 0.89 ENSDART00000017930
potassium channel, subfamily K, member 13a
chr17_-_7436766 0.89 ENSDART00000162002
glutamate receptor, metabotropic 1b
chr18_-_47662696 0.87 ENSDART00000184260

chr10_-_24319526 0.86 ENSDART00000148480
inositol polyphosphate-5-phosphatase Kb
chr13_-_31346392 0.86 ENSDART00000134343
ribosomal RNA processing 12 homolog
chr23_-_333457 0.85 ENSDART00000114486
UHRF1 binding protein 1
chr2_+_42318012 0.85 ENSDART00000138137
finTRIM family, member 8
chr22_+_36914636 0.83 ENSDART00000150948
Pim proto-oncogene, serine/threonine kinase, related 205
chr11_-_12530304 0.80 ENSDART00000143061
zgc:174354
chr3_+_24459709 0.79 ENSDART00000180976
chromobox homolog 6b
chr11_+_11347031 0.79 ENSDART00000172429
ENSDART00000193128
si:dkey-23f9.6
chr16_+_34493987 0.79 ENSDART00000138374
si:ch211-255i3.4
chr25_-_11016675 0.79 ENSDART00000099572
mesoderm posterior ab
chr1_-_57129179 0.79 ENSDART00000157226
ENSDART00000152469
si:ch73-94k4.2
chr9_-_22158325 0.78 ENSDART00000114568
crystallin, gamma M2d16
chr6_+_58622831 0.77 ENSDART00000128793
Sp7 transcription factor
chr11_-_8208464 0.77 ENSDART00000161283
Pim proto-oncogene, serine/threonine kinase, related 203
chr15_+_44366556 0.77 ENSDART00000133449
guanylate cyclase 1 soluble subunit alpha 2
chr25_-_29080063 0.76 ENSDART00000181911
ENSDART00000138087
cytochrome c oxidase subunit Vaa
chr25_+_16194979 0.75 ENSDART00000185592
ENSDART00000158582
ENSDART00000161109
ENSDART00000139013
microtubule associated monooxygenase, calponin and LIM domain containing 2b
chr8_-_4100365 0.75 ENSDART00000142846
cut-like homeobox 2b
chr7_-_35083585 0.75 ENSDART00000192732
agouti related neuropeptide
chr4_+_45357558 0.74 ENSDART00000150769
si:ch211-162i8.5
chr22_+_25242322 0.73 ENSDART00000134628
si:ch211-226h8.8
chr2_-_43850637 0.73 ENSDART00000136077
zinc finger E-box binding homeobox 1a
chr6_+_11250316 0.71 ENSDART00000137122
ATG9 autophagy related 9 homolog A (S. cerevisiae)
chr13_-_8229977 0.70 ENSDART00000139728
si:ch211-250c4.4
chr7_-_41403022 0.70 ENSDART00000174285

chr7_-_20464133 0.70 ENSDART00000078192
canopy4
chr8_+_7756893 0.69 ENSDART00000191894
FYVE, RhoGEF and PH domain containing 1
chr8_+_3431671 0.69 ENSDART00000017850
cytosolic thiouridylase subunit 1 homolog (S. pombe)
chr22_+_25236657 0.68 ENSDART00000138012
zgc:172218
chr3_+_56163276 0.67 ENSDART00000166709
ENSDART00000158540
si:ch73-374l24.1
chr4_-_60049792 0.67 ENSDART00000158199
zinc finger protein 1033
chr4_-_65036768 0.67 ENSDART00000184455
si:ch211-283l16.1
chr3_+_35812040 0.67 ENSDART00000075903
ENSDART00000147712
cytokine receptor-like factor 3
chr12_-_13336703 0.66 ENSDART00000134356
LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
chr19_+_46240171 0.66 ENSDART00000162785
mitogen-activated protein kinase 15
chr15_+_24212847 0.65 ENSDART00000155502
seizure related 6 homolog b
chr8_+_25254435 0.65 ENSDART00000143554
adenosine monophosphate deaminase 2b
chr7_+_38685654 0.64 ENSDART00000180003
synaptotagmin XIII
chr2_+_37424261 0.64 ENSDART00000132427
polyhomeotic homolog 3 (Drosophila)
chr14_+_31493306 0.64 ENSDART00000138341
PHD finger protein 6
chr13_-_50614639 0.64 ENSDART00000170527
ventral expressed homeobox
chr5_+_30680804 0.64 ENSDART00000078049
PDZ domain containing 3b
chr17_-_608857 0.63 ENSDART00000163431
kelch like family member 28
chr22_+_724639 0.63 ENSDART00000105323
zgc:162255
chr1_+_46598764 0.62 ENSDART00000053240
calcium binding protein 39-like
chr5_-_13564961 0.62 ENSDART00000146827
si:ch211-230g14.3
chr7_+_40638210 0.62 ENSDART00000052236
motor neuron and pancreas homeobox 1
chr7_-_38664947 0.62 ENSDART00000100546
ENSDART00000112405
six-cysteine containing astacin protease 1
chr3_+_19446997 0.61 ENSDART00000079352
zgc:123297
chr1_-_28860732 0.61 ENSDART00000177588
translocase of inner mitochondrial membrane domain containing 1
chr4_+_37406676 0.61 ENSDART00000130981
si:ch73-134f24.1
chr21_+_13205859 0.60 ENSDART00000102253
spectrin alpha, non-erythrocytic 1
chr12_+_19030391 0.60 ENSDART00000153927
si:ch73-139e5.2
chr11_-_12232929 0.60 ENSDART00000127611
si:ch211-156l18.4
chr18_-_50986704 0.59 ENSDART00000191435

chr6_-_25952848 0.59 ENSDART00000076997
ENSDART00000148748
LIM domain only 4b
chr7_+_23457803 0.59 ENSDART00000024191
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1
chr22_-_18387059 0.59 ENSDART00000007769
testis-specific serine kinase 6
chr19_+_7810028 0.59 ENSDART00000081592
ENSDART00000140719
aquaporin 10b
chr6_+_15373153 0.59 ENSDART00000155865
teleost multiple tissue opsin 2a
chr22_+_39058269 0.58 ENSDART00000113362
inositol hexakisphosphate kinase 1
chr7_+_22585447 0.58 ENSDART00000149144
cholinergic receptor, nicotinic, beta 1 (muscle) like
chr11_+_11360641 0.57 ENSDART00000159765
si:dkey-23f9.7
chr4_-_77130289 0.57 ENSDART00000174380

chr23_+_26946429 0.57 ENSDART00000185564
calcium channel, voltage-dependent, beta 3b
chr4_+_13428993 0.56 ENSDART00000067151
si:dkey-39a18.1
chr14_+_49602 0.55 ENSDART00000035581
otopetrin 1
chr20_+_44311448 0.54 ENSDART00000114660
opsin 8, group member b
chr1_-_46981134 0.53 ENSDART00000130607
pbx/knotted 1 homeobox 1.2
chr22_+_2830703 0.53 ENSDART00000145463
ENSDART00000144785
si:dkey-20i20.8
chr2_+_24352497 0.52 ENSDART00000134909
Pim proto-oncogene, serine/threonine kinase, related 68
chr4_-_77135076 0.52 ENSDART00000174184
zgc:173770
chr7_-_35083184 0.52 ENSDART00000100253
ENSDART00000135250
ENSDART00000173511
agouti related neuropeptide
chr10_-_40410884 0.52 ENSDART00000150818
trace amine associated receptor 20n
chr18_+_33675664 0.51 ENSDART00000140043
si:dkey-47k20.8
chr2_-_3611960 0.50 ENSDART00000184579
phosphotriesterase related
chr6_+_58832155 0.49 ENSDART00000144842
dynactin 2 (p50)
chr11_-_18017287 0.49 ENSDART00000155443
glutamine-rich 1
chr15_-_35134918 0.49 ENSDART00000157196
si:ch211-272b8.7
chr4_-_77125693 0.48 ENSDART00000174256

chr23_+_3594171 0.48 ENSDART00000159609
si:dkey-9l20.3
chr2_+_33726862 0.47 ENSDART00000146745
si:dkey-31m5.5
chr4_-_72609735 0.46 ENSDART00000174299
ENSDART00000159227
si:cabz01054394.6
chr17_+_50074372 0.46 ENSDART00000113644
vacuolar protein sorting 39 homolog (S. cerevisiae)
chr24_+_15655233 0.46 ENSDART00000143160
F-box protein 15
chr22_+_1330477 0.45 ENSDART00000157567

chr7_-_59311165 0.45 ENSDART00000171105
meiosis 1 associated protein
chr10_+_8481660 0.45 ENSDART00000109559

chr1_+_47178529 0.45 ENSDART00000158432
ENSDART00000074450
ENSDART00000137448
MORC family CW-type zinc finger 3b
chr7_-_25930594 0.44 ENSDART00000192834

chr4_+_73606482 0.44 ENSDART00000150765
si:ch211-165i18.2
chr21_-_14803366 0.43 ENSDART00000190872
si:dkey-11o18.5
chr3_+_23654233 0.43 ENSDART00000078428
homeobox B13a
chr5_+_47975758 0.42 ENSDART00000097429

chr3_+_54744069 0.41 ENSDART00000134958
ENSDART00000114443
si:ch211-74m13.3
chr15_-_11955485 0.41 ENSDART00000160286
si:dkey-202l22.3
chr3_+_34919810 0.41 ENSDART00000055264
carbonic anhydrase Xb
chr22_+_26793389 0.40 ENSDART00000165381
Pim proto-oncogene, serine/threonine kinase, related 69
chr17_+_46739693 0.39 ENSDART00000097810
Pim proto-oncogene, serine/threonine kinase, related 22
chr23_+_7710447 0.39 ENSDART00000168199
kinesin family member 3B
chr19_+_43119698 0.38 ENSDART00000167847
ENSDART00000186962
ENSDART00000187305
eukaryotic translation elongation factor 1 alpha 1, like 1
chr8_+_25962833 0.37 ENSDART00000086583
si:dkey-72l14.4
chr17_-_45155181 0.37 ENSDART00000185274
transmembrane p24 trafficking protein 8
chr5_-_42083363 0.36 ENSDART00000162596
chemokine (C-X-C motif) ligand 11, duplicate 5
chr4_-_39111612 0.36 ENSDART00000150394
si:dkey-122c11.8

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx2.5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 5.9 GO:1905072 cardiac jelly development(GO:1905072)
1.0 4.2 GO:0035994 response to muscle stretch(GO:0035994)
0.6 1.9 GO:0072579 establishment of synaptic specificity at neuromuscular junction(GO:0007529) molybdenum incorporation into molybdenum-molybdopterin complex(GO:0018315) metal incorporation into metallo-molybdopterin complex(GO:0042040) glycine receptor clustering(GO:0072579)
0.6 1.8 GO:1900620 acetylcholine biosynthetic process(GO:0008292) acetate ester biosynthetic process(GO:1900620)
0.6 2.3 GO:1903428 regulation of nitric oxide biosynthetic process(GO:0045428) positive regulation of nitric oxide biosynthetic process(GO:0045429) positive regulation of reactive oxygen species biosynthetic process(GO:1903428) positive regulation of nitric oxide metabolic process(GO:1904407)
0.5 4.8 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.4 1.8 GO:0010874 regulation of cholesterol efflux(GO:0010874)
0.4 2.0 GO:0097510 base-excision repair, AP site formation via deaminated base removal(GO:0097510)
0.4 1.1 GO:1904983 transmembrane glycine transport from cytosol to mitochondrion(GO:1904983)
0.3 1.0 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.3 0.9 GO:0030238 female sex determination(GO:0030237) male sex determination(GO:0030238)
0.3 3.7 GO:0061026 cardiac muscle tissue regeneration(GO:0061026)
0.2 1.0 GO:0021557 oculomotor nerve development(GO:0021557)
0.2 1.4 GO:0045337 farnesyl diphosphate biosynthetic process(GO:0045337)
0.2 2.3 GO:0006798 polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.2 3.7 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.2 4.6 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.2 1.3 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.2 1.3 GO:0008343 adult feeding behavior(GO:0008343) positive regulation of feeding behavior(GO:2000253)
0.2 0.8 GO:0033688 regulation of osteoblast proliferation(GO:0033688) craniofacial suture morphogenesis(GO:0097094)
0.1 0.7 GO:0070587 regulation of cell-cell adhesion involved in gastrulation(GO:0070587)
0.1 1.3 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1 0.8 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 0.8 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.1 0.7 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143) protein urmylation(GO:0032447)
0.1 3.9 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 1.7 GO:0045116 protein neddylation(GO:0045116)
0.1 1.2 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.1 1.5 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 1.7 GO:0006265 DNA topological change(GO:0006265)
0.1 0.5 GO:0007060 male meiosis chromosome segregation(GO:0007060)
0.1 1.2 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.1 2.9 GO:0050821 protein stabilization(GO:0050821)
0.1 0.3 GO:0060063 Spemann organizer formation at the embryonic shield(GO:0060063)
0.1 0.3 GO:0061355 Wnt protein secretion(GO:0061355)
0.1 0.3 GO:0070987 error-free translesion synthesis(GO:0070987)
0.1 0.6 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.1 0.7 GO:0044805 late nucleophagy(GO:0044805)
0.1 1.6 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1 1.3 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.1 0.6 GO:0006833 water transport(GO:0006833)
0.1 1.2 GO:0060034 notochord cell differentiation(GO:0060034)
0.1 0.8 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.5 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.1 1.9 GO:0007340 acrosome reaction(GO:0007340)
0.1 0.8 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.1 0.1 GO:0010658 negative regulation of muscle cell apoptotic process(GO:0010656) muscle cell apoptotic process(GO:0010657) striated muscle cell apoptotic process(GO:0010658) regulation of muscle cell apoptotic process(GO:0010660) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664)
0.1 0.6 GO:0042661 regulation of mesodermal cell fate specification(GO:0042661)
0.1 0.4 GO:0043584 nose development(GO:0043584)
0.1 0.6 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 1.7 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.6 GO:0032264 IMP salvage(GO:0032264)
0.0 0.6 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.9 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.3 GO:0002753 cytoplasmic pattern recognition receptor signaling pathway(GO:0002753)
0.0 0.1 GO:0002940 tRNA N2-guanine methylation(GO:0002940)
0.0 0.3 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 1.1 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.6 GO:0007631 feeding behavior(GO:0007631)
0.0 1.3 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.6 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 0.1 GO:0072512 ferric iron transport(GO:0015682) transferrin transport(GO:0033572) trivalent inorganic cation transport(GO:0072512)
0.0 0.4 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 0.1 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) mediolateral intercalation(GO:0060031)
0.0 0.9 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 1.5 GO:0051017 actin filament bundle assembly(GO:0051017)
0.0 1.1 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.6 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.2 GO:0016119 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.0 0.4 GO:0032418 lysosome localization(GO:0032418)
0.0 10.4 GO:0006397 mRNA processing(GO:0006397)
0.0 0.2 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 0.1 GO:0060465 pharynx development(GO:0060465)
0.0 1.2 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)
0.0 0.3 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 0.5 GO:0039020 pronephric nephron tubule development(GO:0039020)
0.0 0.5 GO:0060037 pharyngeal system development(GO:0060037)
0.0 0.9 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 0.1 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
0.0 0.3 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 4.0 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 1.8 GO:0007601 visual perception(GO:0007601)
0.0 0.3 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.0 GO:0030314 junctional membrane complex(GO:0030314)
0.3 4.3 GO:0005922 connexon complex(GO:0005922)
0.2 1.2 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.2 0.6 GO:0033268 node of Ranvier(GO:0033268)
0.1 1.3 GO:0002142 stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142) stereocilium tip(GO:0032426)
0.1 1.1 GO:0032797 SMN complex(GO:0032797)
0.1 2.3 GO:0043209 myelin sheath(GO:0043209)
0.1 0.7 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.1 8.8 GO:0030018 Z disc(GO:0030018)
0.1 1.3 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 1.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 5.5 GO:0030017 sarcomere(GO:0030017)
0.1 0.8 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 1.7 GO:0099569 presynaptic cytoskeleton(GO:0099569)
0.1 3.7 GO:0070469 respiratory chain(GO:0070469)
0.0 0.6 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 1.8 GO:0043204 perikaryon(GO:0043204)
0.0 1.8 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.3 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 1.5 GO:0030426 growth cone(GO:0030426)
0.0 0.7 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 1.2 GO:0016342 catenin complex(GO:0016342)
0.0 0.9 GO:0099634 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 3.9 GO:0005912 adherens junction(GO:0005912)
0.0 3.0 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 0.7 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 1.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.9 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.6 1.9 GO:0061599 molybdopterin adenylyltransferase activity(GO:0061598) molybdopterin molybdotransferase activity(GO:0061599)
0.5 1.8 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.5 1.4 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.4 1.2 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.3 1.3 GO:0031782 type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.3 4.3 GO:0005243 gap junction channel activity(GO:0005243)
0.2 0.6 GO:0030251 cyclase inhibitor activity(GO:0010852) guanylate cyclase inhibitor activity(GO:0030251)
0.2 2.3 GO:0004309 exopolyphosphatase activity(GO:0004309)
0.2 3.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 2.0 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.1 4.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 1.0 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.1 0.9 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.1 0.8 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 1.7 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.1 0.9 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.1 0.8 GO:0043914 NADPH:sulfur oxidoreductase activity(GO:0043914)
0.1 1.1 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.1 2.3 GO:0005523 tropomyosin binding(GO:0005523)
0.1 1.3 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.1 1.2 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.1 1.7 GO:0097602 cullin family protein binding(GO:0097602)
0.1 1.8 GO:0016854 racemase and epimerase activity(GO:0016854)
0.1 1.1 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 6.0 GO:0051427 hormone receptor binding(GO:0051427)
0.1 0.6 GO:0015168 glycerol transmembrane transporter activity(GO:0015168)
0.1 1.7 GO:0030371 translation repressor activity(GO:0030371)
0.1 1.6 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 0.6 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 1.5 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 2.5 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 0.9 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 0.3 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.3 GO:0042936 dipeptide transporter activity(GO:0042936) dipeptide transmembrane transporter activity(GO:0071916)
0.0 0.3 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 1.0 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.6 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828)
0.0 1.6 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 1.2 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.4 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 1.2 GO:0016307 phosphatidylinositol phosphate kinase activity(GO:0016307)
0.0 1.3 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.1 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.0 0.1 GO:0004998 transferrin receptor activity(GO:0004998)
0.0 0.8 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.4 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.2 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 0.6 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 1.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.4 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.2 GO:0003834 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.0 0.3 GO:0002039 p53 binding(GO:0002039)
0.0 0.7 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.3 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 6.4 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.7 GO:0000049 tRNA binding(GO:0000049)
0.0 6.6 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0090079 translation activator activity(GO:0008494) translation regulator activity, nucleic acid binding(GO:0090079)
0.0 0.4 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 1.7 GO:0005179 hormone activity(GO:0005179)
0.0 0.4 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 1.2 GO:0045296 cadherin binding(GO:0045296)
0.0 2.3 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.6 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 0.8 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.1 GO:0072518 Rho-dependent protein serine/threonine kinase activity(GO:0072518)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 0.7 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 2.3 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 2.9 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.7 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.3 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.3 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 1.0 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 1.0 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 0.7 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 0.1 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.2 PID LPA4 PATHWAY LPA4-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.9 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 0.9 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.1 0.7 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 0.6 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 1.6 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 1.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.4 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.8 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 0.7 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.3 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.2 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 2.4 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 1.1 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 0.2 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.7 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.3 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.3 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 1.0 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases