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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for nkx6.3

Z-value: 0.40

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Transcription factors associated with nkx6.3

Gene Symbol Gene ID Gene Info
nkx6.3
ENSDARG00000060529 NK6 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx6.3dr11_v1_chr8_+_38415374_384153740.449.7e-06Click!

Activity profile of nkx6.3 motif

Sorted Z-values of nkx6.3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_15433518 5.05 ENSDART00000026180
fabp7a
fatty acid binding protein 7, brain, a
chr17_+_15433671 5.00 ENSDART00000149568
fabp7a
fatty acid binding protein 7, brain, a
chr16_+_46111849 4.58 ENSDART00000172232
sv2a
synaptic vesicle glycoprotein 2A
chr16_-_12173554 3.68 ENSDART00000110567
ENSDART00000155935
clstn3
calsyntenin 3
chr9_-_31278048 3.03 ENSDART00000022204
zic5
zic family member 5 (odd-paired homolog, Drosophila)
chr2_-_1486023 3.02 ENSDART00000113774
si:ch211-188c16.1
si:ch211-188c16.1
chr14_+_14662116 2.87 ENSDART00000161693
cetn2
centrin, EF-hand protein, 2
chr6_+_54187643 2.47 ENSDART00000056830
pacsin1b
protein kinase C and casein kinase substrate in neurons 1b
chr20_-_40755614 2.31 ENSDART00000061247
cx32.3
connexin 32.3
chr21_-_13123176 2.24 ENSDART00000144866
ENSDART00000024616
fam219aa
family with sequence similarity 219, member Aa
chr11_-_44801968 1.72 ENSDART00000161846
map1lc3c
microtubule-associated protein 1 light chain 3 gamma
chr21_-_26918901 1.62 ENSDART00000100685
lrfn4a
leucine rich repeat and fibronectin type III domain containing 4a
chr16_-_12173399 1.61 ENSDART00000142574
clstn3
calsyntenin 3
chr20_+_40457599 1.40 ENSDART00000017553
serinc1
serine incorporator 1
chr6_-_16717878 1.30 ENSDART00000153552
nomo
nodal modulator
chr2_+_2223837 1.27 ENSDART00000101038
ENSDART00000129354
tmie
transmembrane inner ear
chr9_+_21793565 1.23 ENSDART00000134915
rev1
REV1, polymerase (DNA directed)
chr16_-_22294265 1.22 ENSDART00000124718
aqp10a
aquaporin 10a
chr4_-_1801519 1.20 ENSDART00000188604
ENSDART00000135749
nudt4b
nudix (nucleoside diphosphate linked moiety X)-type motif 4b
chr21_+_34088110 1.13 ENSDART00000145123
ENSDART00000029599
ENSDART00000147519
mtmr1b
myotubularin related protein 1b
chr20_-_48485354 1.10 ENSDART00000124040
ENSDART00000148437
insm1a
insulinoma-associated 1a
chr2_-_55298075 1.09 ENSDART00000186404
ENSDART00000149062
rab8a
RAB8A, member RAS oncogene family
chr25_-_3058687 1.07 ENSDART00000149117
ENSDART00000137950
si:ch1073-296i8.2
si:ch1073-296i8.2
chr16_-_42965192 1.06 ENSDART00000113714
mtx1a
metaxin 1a
chr4_+_43522680 1.00 ENSDART00000182252
si:dkeyp-53e4.4
si:dkeyp-53e4.4
chr21_+_34088377 0.91 ENSDART00000170070
mtmr1b
myotubularin related protein 1b
chr3_+_18795570 0.88 ENSDART00000042368
fahd1
fumarylacetoacetate hydrolase domain containing 1
chr11_-_34219211 0.85 ENSDART00000098472
tmem44
transmembrane protein 44
chr25_-_8660726 0.74 ENSDART00000168010
ENSDART00000171709
ENSDART00000163426
unc45a
unc-45 myosin chaperone A
chr25_+_24291156 0.72 ENSDART00000083407
b4galnt4a
beta-1,4-N-acetyl-galactosaminyl transferase 4a
chr6_-_12588044 0.71 ENSDART00000047896
slc15a1b
solute carrier family 15 (oligopeptide transporter), member 1b
chr2_-_9818640 0.59 ENSDART00000139499
ENSDART00000165548
ENSDART00000012442
ENSDART00000046587
ap2m1b
adaptor-related protein complex 2, mu 1 subunit, b
chr6_-_37469775 0.57 ENSDART00000156546
plcxd1
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr9_-_43538328 0.45 ENSDART00000140526
znf385b
zinc finger protein 385B
chr17_-_49438873 0.42 ENSDART00000004424
znf292a
zinc finger protein 292a
chr5_+_60590796 0.39 ENSDART00000159859
tmem132e
transmembrane protein 132E
chr23_-_35790235 0.38 ENSDART00000142369
ENSDART00000141141
ENSDART00000011004
mfsd5
major facilitator superfamily domain containing 5
chr8_+_52314542 0.37 ENSDART00000013059
ENSDART00000125241
dbnlb
drebrin-like b
chr10_+_39248911 0.35 ENSDART00000170079
ENSDART00000167974
foxred1
FAD-dependent oxidoreductase domain containing 1
chr13_+_36958086 0.35 ENSDART00000024386
frmd6
FERM domain containing 6
chr5_+_34623107 0.26 ENSDART00000184126
enc1
ectodermal-neural cortex 1
chr20_-_43750771 0.23 ENSDART00000100605
ttc32
tetratricopeptide repeat domain 32
chr5_-_30620625 0.15 ENSDART00000098273
tcnl
transcobalamin like
chr3_-_26787430 0.13 ENSDART00000087047
rab40c
RAB40c, member RAS oncogene family
chr17_-_31483469 0.07 ENSDART00000062907
ENSDART00000061547
ltk
leukocyte receptor tyrosine kinase
chr15_-_34668485 0.07 ENSDART00000186605
bag6
BCL2 associated athanogene 6
chr4_-_2380173 0.06 ENSDART00000177727
nap1l1
nucleosome assembly protein 1-like 1

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx6.3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.3 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.4 3.0 GO:0033278 cell proliferation in midbrain(GO:0033278)
0.3 1.2 GO:0070987 error-free translesion synthesis(GO:0070987)
0.3 1.1 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
0.3 1.3 GO:1900145 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.2 1.2 GO:1901906 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.2 3.7 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.2 1.1 GO:0060221 retinal rod cell differentiation(GO:0060221)
0.1 2.9 GO:0007099 centriole replication(GO:0007099)
0.1 1.7 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 0.7 GO:0006857 oligopeptide transport(GO:0006857)
0.1 0.4 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.1 3.0 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 0.4 GO:0035677 posterior lateral line neuromast hair cell development(GO:0035677)
0.0 2.0 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 4.6 GO:0006836 neurotransmitter transport(GO:0006836)
0.0 0.1 GO:0070285 pigment cell development(GO:0070285)
0.0 0.4 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.7 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.0 0.5 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.1 0.6 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 4.6 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 2.5 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.7 GO:0000421 autophagosome membrane(GO:0000421)
0.0 1.1 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 2.9 GO:0005814 centriole(GO:0005814)
0.0 1.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.4 GO:0002102 podosome(GO:0002102)
0.0 5.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 0.7 GO:0032580 Golgi cisterna membrane(GO:0032580)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 10.1 GO:0005504 fatty acid binding(GO:0005504)
0.3 1.2 GO:0015105 arsenite transmembrane transporter activity(GO:0015105)
0.2 1.2 GO:0034431 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.2 2.0 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.2 0.9 GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.1 0.7 GO:0033842 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity(GO:0033842)
0.1 0.8 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.1 0.7 GO:0042936 dipeptide transporter activity(GO:0042936) dipeptide transmembrane transporter activity(GO:0071916)
0.1 1.2 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.7 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.6 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 1.7 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 1.1 GO:0031490 chromatin DNA binding(GO:0031490)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.9 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes