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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for nr2f2

Z-value: 1.98

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Transcription factors associated with nr2f2

Gene Symbol Gene ID Gene Info
ENSDARG00000040926 nuclear receptor subfamily 2, group F, member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nr2f2dr11_v1_chr18_-_23875370_23875370-0.381.6e-04Click!

Activity profile of nr2f2 motif

Sorted Z-values of nr2f2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_108414 46.04 ENSDART00000170044
apolipoprotein A-Ib
chr19_+_9277327 37.77 ENSDART00000104623
ENSDART00000151164
si:rp71-15k1.1
chr17_-_30702411 36.59 ENSDART00000114358
zgc:194392
chr9_-_9982696 35.84 ENSDART00000192548
ENSDART00000125852
UDP glucuronosyltransferase 1 family a, b
chr7_+_25036188 35.51 ENSDART00000163957
ENSDART00000169749
sb:cb1058
chr18_+_13162728 35.23 ENSDART00000101472
tyrosine aminotransferase
chr10_-_322769 35.19 ENSDART00000165244
v-akt murine thymoma viral oncogene homolog 2, like
chr13_+_37022601 33.28 ENSDART00000131800
ENSDART00000041300
estrogen receptor 2b
chr6_+_60055168 30.24 ENSDART00000008752
phosphoenolpyruvate carboxykinase 1 (soluble)
chr19_-_27564458 25.13 ENSDART00000123155
si:dkeyp-46h3.6
chr20_-_15090862 25.12 ENSDART00000063892
ENSDART00000122592
si:dkey-239i20.2
chr22_-_23668356 24.75 ENSDART00000167106
ENSDART00000159622
ENSDART00000163228
complement factor H
chr16_+_11558868 23.51 ENSDART00000112497
ENSDART00000180445
zgc:198329
chr8_+_30709685 23.37 ENSDART00000133989
ureidopropionase, beta
chr16_+_23913943 22.90 ENSDART00000175404
ENSDART00000129525
apolipoprotein A-IV b, tandem duplicate 1
chr12_-_6033824 22.35 ENSDART00000131301
ENSDART00000139419
ENSDART00000032050
glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1
chr18_-_43866526 22.11 ENSDART00000111309
trehalase (brush-border membrane glycoprotein)
chr12_+_6041575 21.71 ENSDART00000091868
glucose-6-phosphatase a, catalytic subunit, tandem duplicate 2
chr22_+_15624371 20.33 ENSDART00000124868
lipoprotein lipase
chr16_-_22294265 20.20 ENSDART00000124718
aquaporin 10a
chr22_-_24818066 20.07 ENSDART00000143443
vitellogenin 6
chr3_+_12732382 19.82 ENSDART00000158403
cytochrome P450, family 2, subfamily k, polypeptide 19
chr3_-_36750068 19.66 ENSDART00000173388
ATP-binding cassette, sub-family C (CFTR/MRP), member 6b, tandem duplicate 1
chr18_+_40462445 19.34 ENSDART00000087645
UDP glucuronosyltransferase 5 family, polypeptide C2
chr13_-_9886579 18.79 ENSDART00000101926
si:ch211-117n7.7
chr16_-_31675669 18.21 ENSDART00000168848
ENSDART00000158331
complement component 1, r subcomponent
chr10_-_21542702 17.82 ENSDART00000146761
ENSDART00000134502
zgc:165539
chr17_-_49407091 17.59 ENSDART00000021950
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b
chr2_-_20120904 17.53 ENSDART00000186002
ENSDART00000124724
dihydropyrimidine dehydrogenase b
chr21_-_27443995 17.23 ENSDART00000003508
complement component bfb
chr13_-_22843562 16.99 ENSDART00000142738
phenazine biosynthesis like protein domain containing
chr10_+_19569052 16.97 ENSDART00000058425

chr7_-_52096498 16.51 ENSDART00000098688
ENSDART00000098690
cytochrome P450, family 2, subfamily X, polypeptide 10.2
chr5_-_3839285 16.40 ENSDART00000122292
MLX interacting protein like
chr18_-_43866001 16.13 ENSDART00000150218
trehalase (brush-border membrane glycoprotein)
chr25_-_20049449 16.12 ENSDART00000104315
zgc:136858
chr9_+_38292947 16.11 ENSDART00000146663
transcription factor CP2-like 1
chr17_-_2573021 15.97 ENSDART00000074181
zona pellucida glycoprotein 3, tandem duplicate 2
chr22_-_17595310 15.17 ENSDART00000099056
glutathione peroxidase 4a
chr24_-_2843107 15.07 ENSDART00000165290
cytochrome b5 type A (microsomal)
chr17_-_2578026 14.86 ENSDART00000065821
zona pellucida glycoprotein 3, tandem duplicate 2
chr18_+_17611627 14.76 ENSDART00000046891
cholesteryl ester transfer protein, plasma
chr6_-_1768724 13.95 ENSDART00000162488
ENSDART00000163613
zgc:158417
chr3_-_3496738 13.81 ENSDART00000186849

chr13_+_8696825 13.77 ENSDART00000109059
tetratricopeptide repeat domain 7A
chr17_-_2595736 13.72 ENSDART00000128797
zona pellucida glycoprotein 3, tandem duplicate 2
chr3_+_12744083 13.66 ENSDART00000158554
ENSDART00000169545
cytochrome P450, family 2, subfamily k, polypeptide 21
chr23_-_24488696 13.66 ENSDART00000155593
transmembrane protein 82
chr17_-_2590222 13.52 ENSDART00000185711

chr20_-_43741159 13.23 ENSDART00000192621
si:dkeyp-50f7.2
chr22_-_7050 13.19 ENSDART00000127829
ATPase family, AAA domain containing 3
chr18_+_18861359 12.90 ENSDART00000144605
plasmolipin
chr10_-_22797959 12.78 ENSDART00000183269
procollagen C-endopeptidase enhancer a
chr8_+_39802506 12.71 ENSDART00000018862
HNF1 homeobox a
chr3_+_12755535 12.46 ENSDART00000161286
cytochrome P450, family 2, subfamily K, polypeptide17
chr9_+_33216945 12.20 ENSDART00000134029
si:ch211-125e6.12
chr9_+_21151138 12.12 ENSDART00000133903
hydroxyacid oxidase 2 (long chain)
chr17_-_25737452 11.44 ENSDART00000152021
si:ch211-214p16.3
chr21_-_28523548 11.41 ENSDART00000077910
ependymin-like 2
chr20_-_25522911 11.30 ENSDART00000063058
cytochrome P450, family 2, subfamily N, polypeptide 13
chr3_-_18805225 10.94 ENSDART00000133471
ENSDART00000131758
methionine sulfoxide reductase B1a
chr16_+_32029090 10.91 ENSDART00000041054
transmembrane channel-like 4
chr2_+_3533458 10.80 ENSDART00000133007
glutamic pyruvate transaminase (alanine aminotransferase) 2, like
chr17_+_48314724 10.57 ENSDART00000125617
SPARC related modular calcium binding 1
chr3_+_12710350 10.41 ENSDART00000157959
cytochrome P450, family 2, subfamily K, polypeptide 18
chr11_+_6115621 10.28 ENSDART00000165031
ENSDART00000027666
ENSDART00000161458
nuclear receptor subfamily 2, group F, member 6b
chr12_-_5120339 10.20 ENSDART00000168759
retinol binding protein 4, plasma
chr5_-_62317496 10.13 ENSDART00000180089
zgc:85789
chr7_-_38183331 10.11 ENSDART00000149382
ATP-binding cassette, sub-family C (CFTR/MRP), member 12
chr7_-_24520866 10.09 ENSDART00000077039
fatty acid amide hydrolase 2b
chr20_+_2281933 10.01 ENSDART00000137579
si:ch73-18b11.2
chr19_+_17386393 9.92 ENSDART00000034837
ribosomal protein L15
chr1_+_24387659 9.91 ENSDART00000130356
quinoid dihydropteridine reductase b2
chr22_+_15331214 9.88 ENSDART00000136566
sulfotransferase family 3, cytosolic sulfotransferase 4
chr23_-_44786844 9.85 ENSDART00000148669
si:ch73-269m23.5
chr12_-_5120175 9.78 ENSDART00000160729
retinol binding protein 4, plasma
chr25_+_18587338 9.67 ENSDART00000180287
MET proto-oncogene, receptor tyrosine kinase
chr17_-_2584423 9.67 ENSDART00000013506
zona pellucida glycoprotein 3, tandem duplicate 2
chr11_+_41838801 9.48 ENSDART00000014871
aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
chr22_-_38274188 9.32 ENSDART00000139420
ENSDART00000015117
ELAV like neuron-specific RNA binding protein 2
chr6_+_27624023 9.16 ENSDART00000147789
solute carrier organic anion transporter family, member 2A1
chr4_-_19693978 9.11 ENSDART00000100974
ENSDART00000040405
staphylococcal nuclease and tudor domain containing 1
chr20_-_52967878 9.00 ENSDART00000164460
GATA binding protein 4
chr17_+_450956 8.95 ENSDART00000183022
ENSDART00000171386
zgc:194887
chr2_-_24407933 8.79 ENSDART00000088584
si:dkey-208k22.6
chr6_-_2627488 8.75 ENSDART00000044089
ENSDART00000158333
ENSDART00000155109
hydroxypyruvate isomerase
chr15_-_34418525 8.56 ENSDART00000147582
alkylglycerol monooxygenase
chr19_-_3303995 8.55 ENSDART00000105150
si:ch211-133n4.9
chr7_+_59649399 8.51 ENSDART00000123520
ENSDART00000040771
ribosomal protein L34
chr23_-_46040618 8.49 ENSDART00000161415

chr10_-_11385155 8.36 ENSDART00000064214
placenta-specific 8, tandem duplicate 1
chr17_+_20173882 8.18 ENSDART00000155379
si:ch211-248a14.8
chr9_+_8380728 8.17 ENSDART00000133501
si:ch1073-75o15.4
chr18_-_6534357 8.12 ENSDART00000192886
DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
chr12_-_31457301 8.02 ENSDART00000043887
ENSDART00000148603
acyl-CoA synthetase long chain family member 5
chr7_-_51953807 7.97 ENSDART00000174102
ENSDART00000145645
ENSDART00000052054
cytochrome P450, family 2, subfamily X, polypeptide 10.2
chr16_-_33001153 7.90 ENSDART00000147941
malic enzyme 1, NADP(+)-dependent, cytosolic
chr16_-_21785261 7.89 ENSDART00000078858
si:ch73-86n18.1
chr24_-_30275204 7.75 ENSDART00000164187
sorting nexin 7
chr21_+_33454147 7.70 ENSDART00000053208
ribosomal protein S14
chr11_+_6116096 7.65 ENSDART00000159680
nuclear receptor subfamily 2, group F, member 6b
chr3_+_58167288 7.44 ENSDART00000155874
ENSDART00000010395
ubiquinol-cytochrome c reductase core protein 2a
chr16_+_23960933 7.42 ENSDART00000146077
apolipoprotein Eb
chr5_-_20205075 7.30 ENSDART00000051611
D-amino-acid oxidase, tandem duplicate 3
chr15_+_28268135 7.13 ENSDART00000152536
ENSDART00000188550
myosin Ic, paralog b
chr3_+_12718100 7.08 ENSDART00000162343
ENSDART00000192425
cytochrome P450, family 2, subfamily k, polypeptide 20
chr5_+_31605322 7.06 ENSDART00000135037
si:dkey-220k22.3
chr3_+_31662126 7.03 ENSDART00000113441
myosin, light chain kinase 5
chr17_-_15274648 6.84 ENSDART00000141257
c-ros oncogene 1 , receptor tyrosine kinase
chr4_-_5317006 6.73 ENSDART00000150867
si:ch211-214j24.15
chr20_-_36809059 6.69 ENSDART00000062925
solute carrier family 25, member 27
chr1_+_56886214 6.60 ENSDART00000152718
ENSDART00000182408
si:ch211-1f22.8
chr23_-_33738945 6.58 ENSDART00000136386
si:ch211-210c8.7
chr5_-_24238733 6.55 ENSDART00000138170
phospholipid scramblase 3a
chr3_+_31680592 6.52 ENSDART00000172456
myosin, light chain kinase 5
chr19_-_9648542 6.50 ENSDART00000172628
chloride channel, voltage-sensitive 1a
chr19_-_3056235 6.46 ENSDART00000137020
block of proliferation 1
chr2_-_3614005 6.38 ENSDART00000110399
phosphotriesterase related
chr4_+_74396786 6.33 ENSDART00000127501
ENSDART00000174347
zmp:0000001020
chr6_+_53429228 6.31 ENSDART00000165067
abhydrolase domain containing 14B
chr16_-_21489514 6.30 ENSDART00000149525
ENSDART00000148517
ENSDART00000146914
ENSDART00000186493
ENSDART00000193081
ENSDART00000186017
membrane protein, palmitoylated 6a (MAGUK p55 subfamily member 6)
chr4_+_5317483 6.29 ENSDART00000150366
si:ch211-214j24.10
chr8_-_8698607 6.26 ENSDART00000046712
zgc:86609
chr17_-_6613458 6.24 ENSDART00000175024
si:ch211-189e2.3
chr10_+_9561066 6.21 ENSDART00000136281
si:ch211-243g18.2
chr9_+_54984537 6.18 ENSDART00000029528
motile sperm domain containing 2
chr17_+_15213496 6.18 ENSDART00000058351
ENSDART00000131663
glucosamine-phosphate N-acetyltransferase 1
chr2_+_3533117 6.16 ENSDART00000132572
glutamic pyruvate transaminase (alanine aminotransferase) 2, like
chr5_+_43870389 6.16 ENSDART00000141002
zgc:112966
chr21_+_45685757 6.15 ENSDART00000160530
SEC24 homolog A, COPII coat complex component
chr18_-_15771551 6.14 ENSDART00000130931
ENSDART00000154079
si:ch211-219a15.3
chr17_-_29194219 5.95 ENSDART00000157340
spectrin, beta, non-erythrocytic 5
chr12_-_10508952 5.93 ENSDART00000152806
zgc:152977
chr7_+_24520518 5.84 ENSDART00000173604
bloodthirsty-related gene family, member 9
chr6_+_39506043 5.83 ENSDART00000086260

chr3_-_36419641 5.81 ENSDART00000173545
component of oligomeric golgi complex 1
chr21_+_29179887 5.71 ENSDART00000161941
si:ch211-57b15.1
chr25_-_12803723 5.70 ENSDART00000158787
carbonic anhydrase Va
chr1_-_53468160 5.69 ENSDART00000143349
zgc:66455
chr19_+_48024457 5.68 ENSDART00000163823
karyopherin (importin) beta 1
chr25_+_34247107 5.61 ENSDART00000148507
BCL2 interacting protein 2
chr18_+_1615 5.60 ENSDART00000082450
homer scaffolding protein 2
chr10_+_35526528 5.54 ENSDART00000184110
pleckstrin homology-like domain, family B, member 2a
chr3_+_1179601 5.51 ENSDART00000173378
TRIO and F-actin binding protein b
chr21_-_22724980 5.46 ENSDART00000035469
complement component 1, q subcomponent, A chain
chr4_-_31064105 5.38 ENSDART00000157670
si:dkey-11n14.1
chr8_-_22542467 5.35 ENSDART00000182588
ENSDART00000134542
cold shock domain containing E1, RNA-binding
chr21_+_25236297 5.30 ENSDART00000112783
transmembrane protein 45B
chr5_-_36549024 5.26 ENSDART00000097671
zgc:158432
chr2_+_42715995 5.25 ENSDART00000143419
ENSDART00000183914
ENSDART00000184371
ENSDART00000185485
ENSDART00000037332
finTRIM family, member 12
chr9_+_1654284 5.23 ENSDART00000062854
nuclear factor, erythroid 2-like 2a
chr5_-_8171625 5.20 ENSDART00000167643
solute carrier family 1 (glial high affinity glutamate transporter), member 3a
chr25_+_34246625 5.16 ENSDART00000082578
BCL2 interacting protein 2
chr9_+_30464641 5.15 ENSDART00000128357
gap junction protein, alpha 5a
chr2_-_57076687 5.11 ENSDART00000161523
solute carrier family 25, member 42
chr8_-_4097722 5.08 ENSDART00000135006
cut-like homeobox 2b
chr12_+_2648043 5.04 ENSDART00000082220
growth differentiation factor 2
chr17_-_6076266 4.99 ENSDART00000171084
epoxide hydrolase 2, cytoplasmic
chr22_+_15323930 4.96 ENSDART00000142416
si:dkey-236e20.3
chr18_+_25546227 4.93 ENSDART00000085824
peroxisomal biogenesis factor 11 alpha
chr8_+_999421 4.93 ENSDART00000149528
fatty acid binding protein 1b, tandem duplicate 1
chr23_+_44634187 4.90 ENSDART00000143688
si:ch73-265d7.2
chr23_+_2740741 4.84 ENSDART00000134938
zgc:114123
chr23_-_18017946 4.74 ENSDART00000104592
peptidase M20 domain containing 1, tandem duplicate 2
chr9_-_46382637 4.59 ENSDART00000085738
lactase
chr5_+_9218318 4.55 ENSDART00000137774
si:ch211-12e13.1
chr16_+_33143503 4.54 ENSDART00000058471
ENSDART00000179385
rhomboid, veinlet-like 2 (Drosophila)
chr18_-_7400075 4.53 ENSDART00000101250
si:dkey-30c15.13
chr1_-_59240975 4.51 ENSDART00000166170
multivesicular body subunit 12A
chr16_+_38360002 4.48 ENSDART00000087346
ENSDART00000148101
zgc:113232
chr3_+_34121156 4.45 ENSDART00000174929
aldehyde dehydrogenase 3 family, member B1
chr7_-_51775688 4.38 ENSDART00000149793
bone morphogenetic protein 15
chr16_+_23960744 4.38 ENSDART00000058965
apolipoprotein Eb
chr7_+_4384863 4.37 ENSDART00000042955
ENSDART00000134653
slc12a10.3 solute carrier family 12 (sodium/potassium/chloride transporters), member 10, tandem duplicate 3
chr19_-_27564980 4.33 ENSDART00000171967
si:dkeyp-46h3.8
chr2_-_55861351 4.33 ENSDART00000059003
retinal homeobox gene 2
chr18_-_46183462 4.31 ENSDART00000021192
potassium channel, subfamily K, member 6
chr6_+_39499623 4.28 ENSDART00000036057
si:ch211-173n18.3
chr11_+_6116503 4.16 ENSDART00000176170
nuclear receptor subfamily 2, group F, member 6b
chr8_+_20825987 4.08 ENSDART00000133309
si:ch211-133l5.4
chr14_-_32876280 4.07 ENSDART00000173168
si:rp71-46j2.7
chr12_+_1609563 4.05 ENSDART00000163559
solute carrier family 39 member 11
chr6_-_1587291 4.03 ENSDART00000067592
ENSDART00000178877
zgc:123305
chr23_+_9522942 3.97 ENSDART00000137751
oxysterol binding protein-like 2b
chr21_-_1640547 3.96 ENSDART00000151041
zgc:152948
chr3_-_34561624 3.94 ENSDART00000129313
septin 9a
chr24_+_38199829 3.85 ENSDART00000058205
ENSDART00000190285
immunoglobulin light 3 variable 3
chr7_+_33136545 3.85 ENSDART00000173485
intelectin 2
chr10_-_35410518 3.85 ENSDART00000048430
gamma-aminobutyric acid (GABA) A receptor, rho 3a
chr11_+_2198831 3.83 ENSDART00000160515
homeobox C6b
chr3_+_32553714 3.82 ENSDART00000165638
paired box 10
chr5_+_37035978 3.82 ENSDART00000167418
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr18_+_50523870 3.80 ENSDART00000151593
ubiquitin-like 7b (bone marrow stromal cell-derived)
chr20_+_39250673 3.80 ENSDART00000153003
RALBP1 associated Eps domain containing 1
chr20_+_6535438 3.78 ENSDART00000145763
si:ch211-191a24.4
chr11_+_77526 3.70 ENSDART00000193521

chr8_-_33154677 3.70 ENSDART00000133300
zinc finger and BTB domain containing 34
chr2_-_24407732 3.69 ENSDART00000180612
ENSDART00000153688
ENSDART00000179913
si:dkey-208k22.6
chr25_+_36348401 3.69 ENSDART00000103006
histone cluster 1 H2A family member 3
chr3_-_58582663 3.63 ENSDART00000180055

Network of associatons between targets according to the STRING database.

First level regulatory network of nr2f2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
12.7 38.2 GO:0005991 trehalose metabolic process(GO:0005991)
10.1 60.8 GO:0034372 triglyceride-rich lipoprotein particle remodeling(GO:0034370) very-low-density lipoprotein particle remodeling(GO:0034372) reverse cholesterol transport(GO:0043691)
8.2 40.9 GO:0019482 beta-alanine metabolic process(GO:0019482) beta-alanine biosynthetic process(GO:0019483)
7.6 30.2 GO:0006114 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401) short-chain fatty acid catabolic process(GO:0019626) response to dexamethasone(GO:0071548)
5.9 35.2 GO:0006572 tyrosine catabolic process(GO:0006572)
3.9 11.8 GO:0071830 chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830) intermediate-density lipoprotein particle clearance(GO:0071831)
3.8 18.8 GO:0006660 phosphatidylserine catabolic process(GO:0006660) monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
3.3 33.3 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
3.2 54.2 GO:0060046 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
2.9 20.0 GO:0046865 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)
2.7 8.1 GO:1901836 regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901836)
2.7 8.0 GO:0015911 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) plasma membrane long-chain fatty acid transport(GO:0015911) fatty acid transmembrane transport(GO:1902001) positive regulation of anion transmembrane transport(GO:1903961) regulation of fatty acid transport(GO:2000191) positive regulation of fatty acid transport(GO:2000193)
2.2 4.4 GO:0060283 negative regulation of oocyte development(GO:0060283)
1.8 7.3 GO:0006522 alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080) D-alanine family amino acid metabolic process(GO:0046144) D-alanine metabolic process(GO:0046436) D-alanine catabolic process(GO:0055130)
1.7 8.6 GO:0046485 ether lipid metabolic process(GO:0046485)
1.7 87.8 GO:0017144 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
1.5 4.5 GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510)
1.5 9.0 GO:0048795 swim bladder morphogenesis(GO:0048795)
1.4 9.9 GO:1902222 L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
1.3 4.0 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
1.2 8.7 GO:0046487 glyoxylate metabolic process(GO:0046487)
1.2 7.4 GO:0016559 peroxisome fission(GO:0016559)
1.2 20.3 GO:0019433 triglyceride catabolic process(GO:0019433)
1.2 17.6 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
1.1 4.4 GO:2000275 regulation of oxidative phosphorylation uncoupler activity(GO:2000275)
1.0 11.3 GO:0006797 polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
1.0 3.1 GO:0072020 proximal straight tubule development(GO:0072020)
1.0 3.9 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.9 3.5 GO:0055107 Golgi to secretory granule transport(GO:0055107)
0.9 9.7 GO:0021683 cerebellar granular layer development(GO:0021681) cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.9 20.1 GO:0032355 response to estradiol(GO:0032355)
0.9 5.2 GO:0001955 blood vessel maturation(GO:0001955)
0.8 7.9 GO:0006108 malate metabolic process(GO:0006108)
0.7 11.8 GO:1901571 icosanoid transport(GO:0071715) fatty acid derivative transport(GO:1901571)
0.7 9.3 GO:0007143 female meiotic division(GO:0007143)
0.7 5.6 GO:0021553 olfactory nerve development(GO:0021553) olfactory nerve morphogenesis(GO:0021627) olfactory nerve formation(GO:0021628)
0.7 5.5 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.5 5.2 GO:0071379 cellular response to prostaglandin stimulus(GO:0071379)
0.5 1.6 GO:0045040 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.5 2.9 GO:0070813 hydrogen sulfide metabolic process(GO:0070813)
0.5 2.9 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
0.5 6.2 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.5 3.7 GO:0051673 membrane disruption in other organism(GO:0051673)
0.5 1.8 GO:0032534 regulation of microvillus organization(GO:0032530) regulation of microvillus assembly(GO:0032534)
0.4 2.7 GO:0003272 endocardial cushion formation(GO:0003272)
0.4 12.7 GO:0003323 type B pancreatic cell development(GO:0003323)
0.4 6.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.4 2.7 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.4 6.5 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.3 2.0 GO:0048194 Golgi vesicle budding(GO:0048194)
0.3 9.4 GO:0051923 sulfation(GO:0051923)
0.3 7.7 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.3 1.0 GO:0050787 response to mercury ion(GO:0046689) detoxification of mercury ion(GO:0050787)
0.3 2.9 GO:1901998 toxin transport(GO:1901998)
0.3 18.2 GO:0031638 zymogen activation(GO:0031638)
0.3 12.5 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.3 6.7 GO:0009409 response to cold(GO:0009409)
0.3 7.6 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.3 3.1 GO:0034312 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.3 1.9 GO:0016139 glycoside metabolic process(GO:0016137) glycoside catabolic process(GO:0016139)
0.3 5.7 GO:0048251 elastic fiber assembly(GO:0048251)
0.3 6.7 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.3 22.7 GO:0006956 complement activation(GO:0006956)
0.2 3.5 GO:1901642 nucleoside transport(GO:0015858) nucleoside transmembrane transport(GO:1901642)
0.2 10.6 GO:0002072 optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.2 1.1 GO:0018197 peptidyl-aspartic acid modification(GO:0018197) peptidyl-aspartic acid hydroxylation(GO:0042264)
0.2 1.5 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.2 0.8 GO:0071867 response to monoamine(GO:0071867) response to catecholamine(GO:0071869) response to epinephrine(GO:0071871)
0.2 1.4 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.2 6.3 GO:0017121 phospholipid scrambling(GO:0017121)
0.2 3.0 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.2 5.9 GO:0006998 nuclear envelope organization(GO:0006998)
0.2 2.6 GO:0044872 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.2 8.0 GO:0048546 digestive tract morphogenesis(GO:0048546)
0.2 8.6 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.2 5.7 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.2 0.7 GO:0001774 microglial cell activation(GO:0001774)
0.2 3.5 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.2 4.3 GO:0030322 stabilization of membrane potential(GO:0030322)
0.2 5.8 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.2 4.4 GO:0006884 cell volume homeostasis(GO:0006884)
0.2 1.5 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.2 2.1 GO:0010996 response to auditory stimulus(GO:0010996)
0.2 2.9 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.2 4.1 GO:1903845 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.2 7.7 GO:0099515 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.2 2.9 GO:0097475 motor neuron migration(GO:0097475)
0.2 1.2 GO:0070836 membrane raft assembly(GO:0001765) membrane raft organization(GO:0031579) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.1 2.8 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.1 8.9 GO:0051693 actin filament capping(GO:0051693)
0.1 0.4 GO:0072679 thymocyte migration(GO:0072679)
0.1 2.8 GO:0048679 regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.1 1.3 GO:1900407 regulation of cellular response to oxidative stress(GO:1900407)
0.1 13.2 GO:0006979 response to oxidative stress(GO:0006979)
0.1 28.0 GO:0006869 lipid transport(GO:0006869)
0.1 3.5 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 9.9 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 1.9 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 4.3 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.1 3.9 GO:0002377 immunoglobulin production(GO:0002377)
0.1 10.8 GO:0006821 chloride transport(GO:0006821)
0.1 2.5 GO:0016082 synaptic vesicle priming(GO:0016082)
0.1 2.5 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1 6.9 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.1 5.4 GO:0007605 sensory perception of sound(GO:0007605)
0.1 0.5 GO:0006574 valine catabolic process(GO:0006574)
0.1 2.6 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.1 10.9 GO:0030041 actin filament polymerization(GO:0030041)
0.1 2.9 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 1.9 GO:0001757 somite specification(GO:0001757)
0.1 3.1 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.1 1.4 GO:0031103 axon regeneration(GO:0031103)
0.1 0.3 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.1 1.4 GO:0007257 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.1 3.0 GO:0018298 protein-chromophore linkage(GO:0018298)
0.1 1.0 GO:0019835 cytolysis(GO:0019835)
0.1 4.8 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.1 1.3 GO:0018149 peptide cross-linking(GO:0018149)
0.1 0.4 GO:0016576 histone dephosphorylation(GO:0016576) negative regulation of signal transduction in absence of ligand(GO:1901099) regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001239) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.1 10.1 GO:0016042 lipid catabolic process(GO:0016042)
0.1 2.8 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.1 0.4 GO:0031048 chromatin silencing by small RNA(GO:0031048)
0.1 0.9 GO:0018216 peptidyl-arginine methylation(GO:0018216)
0.0 7.8 GO:0001889 liver development(GO:0001889)
0.0 2.8 GO:0006606 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.0 2.1 GO:0006937 regulation of muscle contraction(GO:0006937)
0.0 1.0 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 2.5 GO:0022406 membrane docking(GO:0022406) vesicle docking(GO:0048278)
0.0 0.1 GO:0034729 histone H3-K79 methylation(GO:0034729) regulation of transcription regulatory region DNA binding(GO:2000677)
0.0 1.0 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.3 GO:0030216 keratinocyte differentiation(GO:0030216)
0.0 1.3 GO:0006282 regulation of DNA repair(GO:0006282)
0.0 3.4 GO:0006364 rRNA processing(GO:0006364)
0.0 0.8 GO:0006284 base-excision repair(GO:0006284)
0.0 0.6 GO:0043652 engulfment of apoptotic cell(GO:0043652)
0.0 10.1 GO:0043066 negative regulation of apoptotic process(GO:0043066)
0.0 2.2 GO:0006334 nucleosome assembly(GO:0006334)
0.0 1.2 GO:0002224 toll-like receptor signaling pathway(GO:0002224)
0.0 0.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 2.3 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 2.0 GO:0016197 endosomal transport(GO:0016197)
0.0 0.0 GO:0009750 response to fructose(GO:0009750)
0.0 2.1 GO:0033674 positive regulation of kinase activity(GO:0033674)
0.0 0.6 GO:0009247 glycolipid biosynthetic process(GO:0009247)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 66.4 GO:0042627 chylomicron(GO:0042627)
3.9 11.8 GO:0034362 low-density lipoprotein particle(GO:0034362)
3.1 12.5 GO:0061689 tricellular tight junction(GO:0061689)
3.0 14.8 GO:0034364 high-density lipoprotein particle(GO:0034364)
2.2 6.5 GO:0070545 PeBoW complex(GO:0070545)
1.4 10.9 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
1.1 9.1 GO:0031332 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.6 6.3 GO:0042788 polysomal ribosome(GO:0042788)
0.6 2.5 GO:1990909 Wnt signalosome(GO:1990909)
0.6 6.3 GO:0072546 ER membrane protein complex(GO:0072546)
0.5 3.9 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.5 9.7 GO:0009925 basal plasma membrane(GO:0009925)
0.4 5.8 GO:0017119 Golgi transport complex(GO:0017119)
0.4 5.2 GO:0005922 connexon complex(GO:0005922)
0.3 8.5 GO:0005840 ribosome(GO:0005840)
0.3 0.9 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.3 5.9 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.3 6.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.3 4.5 GO:0000813 ESCRT I complex(GO:0000813)
0.2 1.0 GO:0005579 membrane attack complex(GO:0005579)
0.2 5.5 GO:0045180 basal part of cell(GO:0045178) basal cortex(GO:0045180)
0.2 1.6 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.2 1.9 GO:0098799 mitochondrial outer membrane translocase complex(GO:0005742) outer mitochondrial membrane protein complex(GO:0098799)
0.2 9.0 GO:0030496 midbody(GO:0030496)
0.2 7.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 2.7 GO:0005869 dynactin complex(GO:0005869)
0.2 9.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625) cytosolic ribosome(GO:0022626)
0.1 2.8 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.1 7.7 GO:0005902 microvillus(GO:0005902)
0.1 8.8 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 3.9 GO:0031105 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.1 14.3 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 51.5 GO:0031012 extracellular matrix(GO:0031012)
0.1 3.8 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 2.1 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 133.6 GO:0005576 extracellular region(GO:0005576)
0.1 7.5 GO:0005882 intermediate filament(GO:0005882)
0.1 5.0 GO:0031201 SNARE complex(GO:0031201)
0.1 46.1 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 1.0 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 2.4 GO:0031225 anchored component of membrane(GO:0031225)
0.0 43.2 GO:0005739 mitochondrion(GO:0005739)
0.0 2.0 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 2.9 GO:0030018 Z disc(GO:0030018)
0.0 0.4 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 2.2 GO:0000786 nucleosome(GO:0000786)
0.0 0.5 GO:0034707 chloride channel complex(GO:0034707)
0.0 4.8 GO:0005667 transcription factor complex(GO:0005667)
0.0 72.3 GO:0016021 integral component of membrane(GO:0016021)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
12.7 38.2 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
9.2 46.0 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
6.8 20.3 GO:0034185 apolipoprotein binding(GO:0034185)
5.0 20.2 GO:0015105 arsenite transmembrane transporter activity(GO:0015105)
4.9 54.2 GO:0035804 structural constituent of egg coat(GO:0035804)
4.8 33.3 GO:1903924 estradiol binding(GO:1903924)
3.9 11.8 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
3.5 17.5 GO:0002058 uracil binding(GO:0002058) pyrimidine nucleobase binding(GO:0002061) dihydropyrimidine dehydrogenase (NADP+) activity(GO:0017113)
2.9 20.1 GO:0045735 nutrient reservoir activity(GO:0045735)
2.9 20.0 GO:0034632 retinol transporter activity(GO:0034632)
2.8 25.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
2.7 10.9 GO:0033745 L-methionine-(R)-S-oxide reductase activity(GO:0033745)
2.6 13.2 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
2.5 7.6 GO:0004301 epoxide hydrolase activity(GO:0004301)
2.5 17.6 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
2.5 9.9 GO:0004155 6,7-dihydropteridine reductase activity(GO:0004155) NADH binding(GO:0070404)
2.0 7.9 GO:0004473 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
1.8 7.3 GO:0003884 D-amino-acid oxidase activity(GO:0003884)
1.7 5.1 GO:0071077 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
1.6 101.5 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
1.4 18.8 GO:0047372 acylglycerol lipase activity(GO:0047372)
1.2 8.7 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
1.2 35.2 GO:0008483 transaminase activity(GO:0008483)
1.1 3.4 GO:0008022 protein C-terminus binding(GO:0008022)
1.1 7.7 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
1.0 13.5 GO:0004687 myosin light chain kinase activity(GO:0004687)
1.0 11.3 GO:0004309 exopolyphosphatase activity(GO:0004309)
1.0 8.6 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.9 2.7 GO:0043878 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity(GO:0043878)
0.9 12.9 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.8 30.2 GO:0030145 manganese ion binding(GO:0030145)
0.8 48.2 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.7 8.0 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.6 1.9 GO:0004557 alpha-galactosidase activity(GO:0004557)
0.6 4.4 GO:0070698 type I activin receptor binding(GO:0070698)
0.6 14.8 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.6 9.2 GO:0015245 fatty acid transporter activity(GO:0015245)
0.6 5.5 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.6 12.1 GO:0010181 FMN binding(GO:0010181)
0.5 6.5 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.5 3.1 GO:0017040 ceramidase activity(GO:0017040)
0.5 5.9 GO:0043495 protein anchor(GO:0043495)
0.5 4.4 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.5 2.4 GO:0070573 metallodipeptidase activity(GO:0070573)
0.5 38.6 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.5 1.8 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.5 1.4 GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113)
0.5 3.2 GO:0030274 LIM domain binding(GO:0030274)
0.4 2.6 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.4 7.8 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.4 5.2 GO:0005243 gap junction channel activity(GO:0005243)
0.4 6.5 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.4 2.2 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.3 4.0 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.3 10.9 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.3 1.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.3 1.8 GO:0004630 phospholipase D activity(GO:0004630)
0.2 1.4 GO:0042169 SH2 domain binding(GO:0042169)
0.2 15.1 GO:0009055 electron carrier activity(GO:0009055)
0.2 6.1 GO:0015248 sterol transporter activity(GO:0015248)
0.2 0.9 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.2 8.1 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.2 2.0 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.2 7.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.2 6.4 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.2 2.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 2.1 GO:0030172 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.2 1.6 GO:0015250 water channel activity(GO:0015250)
0.2 4.3 GO:0022841 leak channel activity(GO:0022840) potassium ion leak channel activity(GO:0022841) narrow pore channel activity(GO:0022842)
0.2 2.1 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.2 3.9 GO:0070492 oligosaccharide binding(GO:0070492)
0.2 3.0 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.2 2.6 GO:0016018 drug binding(GO:0008144) cyclosporin A binding(GO:0016018)
0.2 2.8 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.2 1.9 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.2 1.4 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.2 35.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 1.8 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.2 9.1 GO:0004521 endoribonuclease activity(GO:0004521)
0.1 1.5 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.1 7.7 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 3.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 19.4 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.1 1.3 GO:0043142 single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116) single-stranded DNA-dependent ATPase activity(GO:0043142)
0.1 15.8 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.1 1.5 GO:0008422 beta-glucosidase activity(GO:0008422)
0.1 0.5 GO:0008442 3-hydroxyisobutyrate dehydrogenase activity(GO:0008442)
0.1 16.9 GO:0016798 hydrolase activity, acting on glycosyl bonds(GO:0016798)
0.1 3.8 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 6.2 GO:0048029 monosaccharide binding(GO:0048029)
0.1 2.6 GO:0004623 phospholipase A2 activity(GO:0004623)
0.1 8.9 GO:0008146 sulfotransferase activity(GO:0008146)
0.1 2.9 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 6.5 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.1 10.1 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.1 9.3 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.1 0.8 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.1 5.0 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 13.0 GO:0030246 carbohydrate binding(GO:0030246)
0.1 2.9 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 1.3 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 0.3 GO:0050780 mu-type opioid receptor binding(GO:0031852) dopamine receptor binding(GO:0050780) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 3.0 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.1 4.2 GO:0001594 trace-amine receptor activity(GO:0001594)
0.1 11.1 GO:0005125 cytokine activity(GO:0005125)
0.1 10.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 1.0 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.1 0.8 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 1.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 47.1 GO:0008270 zinc ion binding(GO:0008270)
0.0 0.4 GO:0002020 protease binding(GO:0002020)
0.0 0.7 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 2.7 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 1.3 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 4.5 GO:0016853 isomerase activity(GO:0016853)
0.0 0.9 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.1 GO:0031151 histone methyltransferase activity (H3-K79 specific)(GO:0031151)
0.0 2.0 GO:0051427 hormone receptor binding(GO:0051427)
0.0 1.7 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 1.6 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.0 0.4 GO:0030506 ankyrin binding(GO:0030506)
0.0 1.1 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 1.9 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 3.5 GO:0008134 transcription factor binding(GO:0008134)
0.0 3.7 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 7.8 GO:0005198 structural molecule activity(GO:0005198)
0.0 0.1 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0 1.8 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)
0.0 2.5 GO:0015293 symporter activity(GO:0015293)
0.0 0.5 GO:0005254 chloride channel activity(GO:0005254)
0.0 5.1 GO:0046983 protein dimerization activity(GO:0046983)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 78.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.4 9.7 PID ARF6 PATHWAY Arf6 signaling events
0.3 5.2 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2 5.0 PID ALK1 PATHWAY ALK1 signaling events
0.1 7.1 PID CMYB PATHWAY C-MYB transcription factor network
0.1 5.3 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 4.3 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 3.8 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.1 1.4 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 1.3 PID ARF 3PATHWAY Arf1 pathway
0.1 1.1 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 6.7 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.9 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.9 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.2 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
10.1 30.2 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
7.1 42.8 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
6.2 24.8 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
2.9 23.4 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
2.0 20.3 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
1.5 14.8 REACTOME LIPOPROTEIN METABOLISM Genes involved in Lipoprotein metabolism
1.1 9.2 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
1.0 8.0 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.7 9.0 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.7 4.3 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.7 3.6 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.7 12.7 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.5 5.5 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.4 6.0 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.4 6.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.3 11.3 REACTOME MYOGENESIS Genes involved in Myogenesis
0.3 15.1 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.2 2.9 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.2 26.1 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.2 38.1 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.2 9.4 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2 3.5 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.2 2.4 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.2 0.7 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.1 3.1 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 8.1 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 1.5 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.1 1.4 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 1.8 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 5.1 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism
0.0 1.0 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 1.5 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import