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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for otx5

Z-value: 0.69

Motif logo

Transcription factors associated with otx5

Gene Symbol Gene ID Gene Info
ENSDARG00000043483 orthodenticle homolog 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
otx5dr11_v1_chr15_+_47903864_47903864-0.302.9e-03Click!

Activity profile of otx5 motif

Sorted Z-values of otx5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_3629201 11.37 ENSDART00000136577
ENSDART00000132121
inter-alpha-trypsin inhibitor heavy chain 3a
chr15_-_5815006 9.21 ENSDART00000102459
retinol binding protein 2a, cellular
chr14_-_41308561 7.35 ENSDART00000138232
ADP-ribosylation factor-like 13A
chr4_-_17409533 6.00 ENSDART00000011943
phenylalanine hydroxylase
chr4_-_8030583 5.90 ENSDART00000113628
si:ch211-240l19.8
chr20_+_53441935 5.85 ENSDART00000175214
apolipoprotein Bb, tandem duplicate 2
chr10_+_28428222 5.39 ENSDART00000135003
si:ch211-222e20.4
chr12_-_4301234 4.30 ENSDART00000152377
ENSDART00000152521
carbonic anhydrase XVb
chr20_-_33566640 4.26 ENSDART00000159729
si:dkey-65b13.9
chr4_-_77432218 4.19 ENSDART00000158683
solute carrier organic anion transporter family, member 1D1
chr4_-_77125693 4.05 ENSDART00000174256

chr16_+_34111919 3.83 ENSDART00000134037
ENSDART00000006061
ENSDART00000140552
transcription elongation factor A (SII), 3
chr3_-_54544612 3.43 ENSDART00000018044
angiopoietin-like 6
chr3_+_49521106 3.37 ENSDART00000162799
crumbs homolog 3a
chr25_+_192116 3.25 ENSDART00000153983
zgc:114188
chr5_-_69180587 3.11 ENSDART00000156681
ENSDART00000160753
zgc:171967
chr3_+_12725343 3.10 ENSDART00000188583
cytochrome P450, family 2, subfamily k, polypeptide 20
chr11_+_29671661 3.08 ENSDART00000024318
ENSDART00000165024
ring finger protein 207a
chr4_+_18804317 3.08 ENSDART00000101043
solute carrier family 26 (anion exchanger), member 3, tandem duplicate 2
chr16_-_26537103 3.03 ENSDART00000134908
ENSDART00000008152
serum/glucocorticoid regulated kinase 2b
chr4_-_77130289 3.03 ENSDART00000174380

chr3_+_16762483 3.02 ENSDART00000132732
transmembrane protein 86B
chr3_+_16229911 2.98 ENSDART00000121728
ribosomal protein L19
chr23_-_31266586 2.85 ENSDART00000139746
si:dkey-261l7.2
chr10_-_1961930 2.63 ENSDART00000122446
teratocarcinoma-derived growth factor 1
chr11_+_18037729 2.62 ENSDART00000111624
zgc:175135
chr21_-_20733615 2.58 ENSDART00000145544
si:ch211-22d5.2
chr23_+_44349252 2.55 ENSDART00000097644
eph receptor B4b
chr24_+_10898671 2.46 ENSDART00000106272
si:dkey-37o8.1
chr10_-_20445549 2.46 ENSDART00000064613
lysyl oxidase-like 2a
chr5_-_69180227 2.37 ENSDART00000154816
zgc:171967
chr18_-_16795262 2.36 ENSDART00000048722
adenosine monophosphate deaminase 3b
chr16_+_23403602 2.35 ENSDART00000159848
S100 calcium binding protein W
chr4_-_76303301 2.35 ENSDART00000158504
zgc:174944
chr3_+_48561112 2.34 ENSDART00000159682
solute carrier family 16 (monocarboxylate transporter), member 5b
chr15_+_5973909 2.33 ENSDART00000126886
ENSDART00000189618
immunoglobulin superfamily, member 5b
chr14_+_15620640 2.32 ENSDART00000188867
si:dkey-203a12.9
chr8_+_24747865 2.30 ENSDART00000078656
solute carrier family 16, member 4
chr18_-_50799510 2.29 ENSDART00000174373
transaldolase 1
chr4_-_76105527 2.27 ENSDART00000159108
zgc:110171
chr24_-_28245872 2.23 ENSDART00000167861
cytochrome c oxidase subunit IV isoform 1, like
chr11_-_11336986 2.21 ENSDART00000016677
zgc:77929
chr22_-_16154771 2.15 ENSDART00000009464
solute carrier family 30 (zinc transporter), member 7
chr4_-_75795899 2.10 ENSDART00000157925
si:dkey-261j11.1
chr10_+_6013076 2.09 ENSDART00000167613
ENSDART00000159216
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr14_+_15430991 2.08 ENSDART00000158221
si:dkey-203a12.5
chr4_+_20566371 2.07 ENSDART00000127576

chr7_-_66864756 2.05 ENSDART00000184462
ENSDART00000189424
adenosine monophosphate deaminase 3a
chr10_-_22506044 2.02 ENSDART00000100497
zgc:172339
chr4_+_9508505 1.99 ENSDART00000080842
kit ligand b
chr15_+_31426768 1.98 ENSDART00000014270
odorant receptor, family C, subfamily 103, member 1
chr11_+_14287427 1.96 ENSDART00000180903
si:ch211-262i1.3
chr3_-_20957011 1.96 ENSDART00000159787
ENSDART00000180531
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 4, like
chr17_-_25737452 1.94 ENSDART00000152021
si:ch211-214p16.3
chr4_+_42175261 1.91 ENSDART00000162193
si:ch211-142b24.2
chr2_+_7192966 1.91 ENSDART00000142735
si:ch211-13f8.1
chr23_-_45955177 1.90 ENSDART00000165963
ENSDART00000186649
ENSDART00000185773

chr17_+_50701748 1.90 ENSDART00000191938
ENSDART00000183220
ENSDART00000049464
fermitin family member 2
chr16_-_40043322 1.81 ENSDART00000145278
si:dkey-29b11.3
chr4_+_76973771 1.73 ENSDART00000142978
si:dkey-240n22.3
chr22_-_26484268 1.71 ENSDART00000110293
zgc:194551
chr6_-_39764995 1.68 ENSDART00000085277
phosphofructokinase, muscle b
chr7_-_26049282 1.68 ENSDART00000136389
ENSDART00000101124
ribonuclease, RNase K a
chr9_+_18829360 1.65 ENSDART00000006514
general transcription factor IIF, polypeptide 2b
chr22_+_25140904 1.62 ENSDART00000143114
si:dkeyp-20e4.8
chr10_-_36738619 1.60 ENSDART00000093000
ENSDART00000157179
si:ch211-176g13.7
chr22_-_8509215 1.60 ENSDART00000140146
si:ch73-27e22.3
chr9_+_1313418 1.57 ENSDART00000191361
caspase 8, apoptosis-related cysteine peptidase, like 2
chr15_-_36727462 1.56 ENSDART00000085971
nephrosis 1, congenital, Finnish type (nephrin)
chr16_-_25741225 1.56 ENSDART00000130641
B cell CLL/lymphoma 3
chr18_-_40684756 1.55 ENSDART00000113799
ENSDART00000139042
si:ch211-132b12.7
chr25_+_19041329 1.55 ENSDART00000153467
leucine-rich repeats and transmembrane domains 2b
chr19_-_2115040 1.55 ENSDART00000020497
sorting nexin 13
chr4_+_25558849 1.51 ENSDART00000113663
ENSDART00000100755
ENSDART00000111416
ENSDART00000127840
ENSDART00000168618
ENSDART00000111820
ENSDART00000113866
ENSDART00000110107
ENSDART00000111344
ENSDART00000108548
zgc:195175
chr8_+_6954984 1.51 ENSDART00000145610
si:ch211-255g12.6
chr20_+_51478939 1.51 ENSDART00000149758
toll-like receptor 5a
chr4_+_62431132 1.50 ENSDART00000160226
si:ch211-79g12.1
chr23_+_39854566 1.50 ENSDART00000190423
ENSDART00000164473
ENSDART00000161881
si:ch73-217b7.1
chr20_+_9128829 1.50 ENSDART00000064144
ENSDART00000137450
bisphosphate nucleotidase 1
chr25_-_27819838 1.49 ENSDART00000067106
leiomodin 2 (cardiac) a
chr21_-_43428040 1.49 ENSDART00000148325
serine/threonine protein kinase 26
chr4_-_13614797 1.48 ENSDART00000138366
ENSDART00000165212
interferon regulatory factor 5
chr19_-_3261019 1.46 ENSDART00000134407
si:ch211-133n4.12
chr23_+_39963599 1.46 ENSDART00000166539
FYVE and coiled-coil domain containing 1a
chr9_-_12574473 1.46 ENSDART00000191372
ENSDART00000193667
insulin-like growth factor 2 mRNA binding protein 2a
chr18_+_48758916 1.45 ENSDART00000060098
gem (nuclear organelle) associated protein 7
chr18_+_33490315 1.45 ENSDART00000140885
ENSDART00000155210
vomeronasal 2 receptor, h1
chr3_+_46764278 1.43 ENSDART00000136051
ENSDART00000164930
protein kinase C substrate 80K-H
chr19_+_43715911 1.42 ENSDART00000006344
CAP, adenylate cyclase-associated protein 1 (yeast)
chr25_-_17552299 1.40 ENSDART00000154327
si:dkey-44k1.5
chr1_+_8110562 1.38 ENSDART00000112160
si:dkeyp-9d4.5
chr14_+_2487672 1.38 ENSDART00000170629
ENSDART00000123063
fibroblast growth factor 18a
chr18_-_42071876 1.37 ENSDART00000193288
ENSDART00000189021
ENSDART00000019245
Rho GTPase activating protein 42b
chr14_+_31751260 1.37 ENSDART00000169796
si:dkeyp-11e3.1
chr11_-_3366782 1.35 ENSDART00000127982
sulfite oxidase
chr16_+_23404170 1.34 ENSDART00000170061
S100 calcium binding protein W
chr17_+_4427463 1.34 ENSDART00000131593
si:zfos-364h11.2
chr16_+_44906324 1.32 ENSDART00000074960
cd22 molecule
chr4_+_58667348 1.32 ENSDART00000186596
ENSDART00000180673

chr9_+_20519846 1.31 ENSDART00000109680
ENSDART00000142220
V-set domain containing T cell activation inhibitor 1
chr4_-_14470071 1.31 ENSDART00000143773
plexin b2a
chr3_-_54524194 1.30 ENSDART00000155406
ENSDART00000111791
si:ch73-208g10.1
chr25_+_469855 1.29 ENSDART00000104717
ribosomal L24 domain containing 1
chr3_-_27647845 1.24 ENSDART00000151625
si:ch211-157c3.4
chr11_+_6136220 1.23 ENSDART00000082223
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr16_+_52343905 1.20 ENSDART00000131051
interferon lambda receptor 1
chr2_-_31686353 1.20 ENSDART00000126177
ENSDART00000056679
E2F transcription factor 5
chr17_-_8592824 1.19 ENSDART00000127022

chr4_+_18441988 1.15 ENSDART00000040827
non-SMC condensin II complex, subunit H2
chr4_+_36616118 1.14 ENSDART00000160058
ENSDART00000170506
si:dkey-151g22.1
chr4_-_71554068 1.13 ENSDART00000167414
si:dkey-27n6.1
chr23_+_7505943 1.13 ENSDART00000135787
HCK proto-oncogene, Src family tyrosine kinase
chr10_-_1961576 1.12 ENSDART00000042441
teratocarcinoma-derived growth factor 1
chr4_+_43245188 1.11 ENSDART00000150310
si:dkey-29j8.1
chr8_-_2543327 1.11 ENSDART00000134115
si:ch211-51h9.6
chr24_+_17005647 1.09 ENSDART00000149149
zinc finger protein, X-linked
chr11_-_15090564 1.09 ENSDART00000162079
solute carrier family 1 (glutamate transporter), member 8a
chr18_+_27218737 1.09 ENSDART00000111450
pleckstrin homology domain containing, family A member 7a
chr4_-_49133107 1.08 ENSDART00000150806
zinc finger protein 1146
chr14_+_15191176 1.07 ENSDART00000183447
ENSDART00000193093
ENSDART00000169309
si:dkey-203a12.2
chr3_-_25119839 1.06 ENSDART00000154724
chondroadherin-like a
chr4_+_75575252 1.06 ENSDART00000166536
si:ch211-227e10.1
chr4_-_76186742 1.05 ENSDART00000163970
si:ch211-106j21.4
chr20_+_6533260 1.05 ENSDART00000135005
ENSDART00000166356
si:ch211-191a24.4
chr11_+_31558207 1.05 ENSDART00000140204
egl-9 family hypoxia-inducible factor 1b
chr4_+_70341246 1.04 ENSDART00000123408
si:ch211-76m11.3
chr19_-_9760994 1.04 ENSDART00000139727
si:dkey-14o18.2
chr23_+_25291891 1.00 ENSDART00000016248
proliferation-associated 2G4, b
chr8_+_2656231 1.00 ENSDART00000160833
family with sequence similarity 102, member Aa
chr8_+_21297217 1.00 ENSDART00000142836
inositol 1,4,5-trisphosphate receptor, type 3
chr14_-_1280907 1.00 ENSDART00000186150

chr2_+_51783120 0.99 ENSDART00000177559
crystallin, gamma N1
chr12_+_9320783 0.97 ENSDART00000152526
potassium voltage-gated channel, subfamily H (eag-related), member 6b
chr1_+_8111009 0.96 ENSDART00000152192
si:dkeyp-9d4.5
chr9_+_3519191 0.96 ENSDART00000008606
methyltransferase like 8
chr4_-_49884959 0.95 ENSDART00000190248
si:dkey-156k2.3
chr1_-_46859398 0.95 ENSDART00000135795
1-acylglycerol-3-phosphate O-acyltransferase 3
chr12_-_30777540 0.94 ENSDART00000126466
ectonucleoside triphosphate diphosphohydrolase 1
chr6_+_46481024 0.93 ENSDART00000155596
si:dkey-7k24.5
chr4_-_71471302 0.91 ENSDART00000187687
si:ch211-76m11.5
chr24_+_36317544 0.91 ENSDART00000048640
ENSDART00000156096
pseudouridylate synthase 3
chr11_+_31680513 0.90 ENSDART00000139900
ENSDART00000040305
diaphanous-related formin 3
chr20_-_45722895 0.90 ENSDART00000153273
glycerophosphocholine phosphodiesterase 1
chr17_+_16046132 0.89 ENSDART00000155005
si:ch73-204p21.2
chr1_+_29515160 0.89 ENSDART00000152226
si:dkey-228l14.1
chr4_+_43225728 0.89 ENSDART00000158639
ENSDART00000141339
ENSDART00000137770
ENSDART00000166019
si:ch211-76m11.5
chr22_+_38164486 0.88 ENSDART00000137521
transmembrane 4 L six family member 18
chr20_+_30725778 0.88 ENSDART00000062532
NHS-like 1b
chr22_-_26005894 0.87 ENSDART00000105088
platelet-derived growth factor alpha polypeptide a
chr24_+_19518303 0.87 ENSDART00000027022
ENSDART00000056080
sulfatase 1
chr4_-_71214516 0.86 ENSDART00000169997
si:ch211-205a14.7
chr13_+_25486608 0.85 ENSDART00000057689
BCL2 associated athanogene 3
chr10_+_19525839 0.85 ENSDART00000162912
ENSDART00000158512
V-set and immunoglobulin domain containing 8a
chr18_+_33353755 0.85 ENSDART00000144160
vomeronasal 2 receptor, h13
chr6_-_39521832 0.85 ENSDART00000065038
activating transcription factor 1
chr18_+_45862414 0.84 ENSDART00000024615
arginyl aminopeptidase like 1
chr15_-_29510074 0.83 ENSDART00000184070

chr9_+_343062 0.83 ENSDART00000164012
ENSDART00000164365
BPI fold containing family C, like
chr7_+_8456999 0.82 ENSDART00000172880
jacalin 4
chr4_-_52783184 0.82 ENSDART00000172283
si:dkey-4j21.2
chr17_+_31237866 0.80 ENSDART00000076943
prolactin releasing hormone 2 receptor
chr4_-_39186893 0.79 ENSDART00000150371
ENSDART00000121804
ENSDART00000133901
si:ch211-22k7.9
chr6_+_32834760 0.79 ENSDART00000121562
cylindromatosis (turban tumor syndrome), like
chr22_-_12726556 0.79 ENSDART00000105776
family with sequence similarity 207, member A
chr1_-_58009216 0.77 ENSDART00000143829
nucleoredoxin like 1
chr3_+_14157090 0.76 ENSDART00000156766
si:ch211-108d22.2
chr5_-_1827575 0.76 ENSDART00000171193
mutated in colorectal cancers
chr4_-_33763221 0.76 ENSDART00000132613
ENSDART00000191816
ENSDART00000188473
si:ch211-197f20.1
chr4_-_56103062 0.75 ENSDART00000165784
ENSDART00000190846
si:dkey-16p6.1
chr3_+_23703704 0.74 ENSDART00000024256
homeobox B6a
chr18_+_2189211 0.74 ENSDART00000170827
cell cycle progression 1
chr4_+_58661331 0.74 ENSDART00000188763

chr3_+_26144765 0.74 ENSDART00000146267
ENSDART00000043932
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
chr12_-_16558106 0.74 ENSDART00000109033
si:dkey-269i1.4
chr4_-_61419027 0.73 ENSDART00000181567
ENSDART00000187397
ENSDART00000180671
ENSDART00000164053
ENSDART00000187395
zinc finger protein 1021
chr4_+_51201875 0.72 ENSDART00000189875
ENSDART00000186722

chr22_-_26100282 0.72 ENSDART00000166075
platelet-derived growth factor alpha polypeptide a
chr4_+_67994238 0.71 ENSDART00000160968
si:ch211-133h13.1
chr4_-_34459615 0.71 ENSDART00000169144
ENSDART00000167022
si:ch211-64i20.3
chr4_-_43919359 0.71 ENSDART00000184163
ENSDART00000158019
ENSDART00000191745
ENSDART00000181638
ENSDART00000150827
zinc finger protein 1104
chr22_-_5006119 0.69 ENSDART00000187998
retinal homeobox gene 1
chr12_+_31537604 0.68 ENSDART00000153340
si:ch73-205h11.1
chr13_+_22863516 0.67 ENSDART00000113082
ENSDART00000189200
heterogeneous nuclear ribonucleoprotein H3 (2H9)
chr9_-_3519253 0.67 ENSDART00000169586
ddb1 and cul4 associated factor 17
chr4_-_34460301 0.67 ENSDART00000192977
si:ch211-64i20.3
chr21_+_5080789 0.67 ENSDART00000024199
ATP synthase F1 subunit alpha
chr3_+_24094581 0.67 ENSDART00000138270
ENSDART00000131509
coatomer protein complex, subunit zeta 2
chr20_+_29587995 0.67 ENSDART00000153339
ADAM metallopeptidase domain 17b
chr24_+_14527935 0.66 ENSDART00000134846
si:dkeyp-73g8.5
chr4_-_47095583 0.66 ENSDART00000183595
ENSDART00000183279
ENSDART00000191638
si:dkey-26m3.3
chr3_-_26183699 0.65 ENSDART00000147517
ENSDART00000140731
si:ch211-11k18.4
chr5_-_30074332 0.65 ENSDART00000147963
beta-carotene oxygenase 2a
chr4_+_57192681 0.65 ENSDART00000190438
si:dkey-16p6.4
chr4_-_67984478 0.65 ENSDART00000160623
si:ch211-223k15.1
chr4_+_46812891 0.65 ENSDART00000189655
ENSDART00000162329
si:ch211-215p11.3
chr4_+_35227135 0.65 ENSDART00000161023
ENSDART00000182403
si:ch211-276i6.1
chr4_+_60547709 0.65 ENSDART00000158732
si:dkey-211i20.5
chr4_-_63559311 0.64 ENSDART00000164415
si:dkey-16p6.1
chr12_-_30777743 0.64 ENSDART00000148888
ectonucleoside triphosphate diphosphohydrolase 1
chr7_-_17779644 0.64 ENSDART00000128504
si:dkey-106g10.7

Network of associatons between targets according to the STRING database.

First level regulatory network of otx5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 7.3 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500) protein localization to ciliary membrane(GO:1903441)
1.2 3.7 GO:0090008 hypoblast development(GO:0090008)
1.2 5.8 GO:0006642 triglyceride mobilization(GO:0006642)
0.8 2.4 GO:0010656 negative regulation of muscle cell apoptotic process(GO:0010656) muscle cell apoptotic process(GO:0010657) striated muscle cell apoptotic process(GO:0010658) regulation of muscle cell apoptotic process(GO:0010660) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664)
0.7 2.1 GO:1902767 farnesyl diphosphate biosynthetic process, mevalonate pathway(GO:0010142) isoprenoid biosynthetic process via mevalonate(GO:1902767)
0.6 2.5 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.5 6.0 GO:0006558 L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.5 2.3 GO:0009052 pentose-phosphate shunt, non-oxidative branch(GO:0009052)
0.4 1.3 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.4 1.2 GO:2000008 regulation of protein localization to cell surface(GO:2000008) negative regulation of protein localization to cell surface(GO:2000009)
0.4 1.6 GO:0042754 negative regulation of circadian rhythm(GO:0042754)
0.4 1.5 GO:0034146 toll-like receptor 5 signaling pathway(GO:0034146)
0.4 1.1 GO:0045218 zonula adherens maintenance(GO:0045218)
0.3 1.6 GO:0003261 cardiac muscle progenitor cell migration to the midline involved in heart field formation(GO:0003261)
0.3 1.5 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.3 1.2 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.3 1.6 GO:0071405 response to methanol(GO:0033986) cellular response to methanol(GO:0071405)
0.2 4.3 GO:0008354 germ cell migration(GO:0008354)
0.2 2.3 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.2 4.2 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.2 0.7 GO:0014724 regulation of twitch skeletal muscle contraction(GO:0014724) regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448) negative regulation of striated muscle contraction(GO:0045988) relaxation of skeletal muscle(GO:0090076)
0.2 0.9 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.2 2.0 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.2 2.4 GO:0032264 IMP salvage(GO:0032264)
0.2 2.2 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.2 1.5 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.2 3.4 GO:1902017 regulation of cilium assembly(GO:1902017)
0.1 3.1 GO:0015701 bicarbonate transport(GO:0015701)
0.1 0.4 GO:1904729 regulation of intestinal absorption(GO:1904478) regulation of intestinal lipid absorption(GO:1904729)
0.1 3.0 GO:1901888 regulation of cell junction assembly(GO:1901888)
0.1 0.5 GO:0014743 regulation of muscle hypertrophy(GO:0014743)
0.1 0.5 GO:0016038 absorption of visible light(GO:0016038)
0.1 0.6 GO:0030326 embryonic limb morphogenesis(GO:0030326)
0.1 1.4 GO:0030816 activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762)
0.1 0.9 GO:2000290 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)
0.1 0.7 GO:1905097 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.1 0.6 GO:0035332 positive regulation of hippo signaling(GO:0035332)
0.1 6.3 GO:0006414 translational elongation(GO:0006414)
0.1 0.3 GO:0015884 folic acid transport(GO:0015884) drug transport(GO:0015893) methotrexate transport(GO:0051958) reduced folate transmembrane transport(GO:0098838)
0.1 0.5 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1 0.2 GO:0002828 regulation of type 2 immune response(GO:0002828)
0.1 0.7 GO:0046247 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.1 2.1 GO:0006829 zinc II ion transport(GO:0006829)
0.1 0.5 GO:0034389 lipid particle organization(GO:0034389)
0.1 1.5 GO:0071545 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.1 1.4 GO:0006491 N-glycan processing(GO:0006491)
0.1 3.1 GO:0042738 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.1 1.9 GO:0055008 cardiac muscle tissue morphogenesis(GO:0055008)
0.1 1.0 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.1 4.6 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 1.2 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 1.6 GO:0003094 glomerular filtration(GO:0003094)
0.0 1.8 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.9 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.6 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0 1.4 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.9 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.0 4.2 GO:0048545 response to steroid hormone(GO:0048545)
0.0 0.4 GO:0030431 sleep(GO:0030431)
0.0 0.5 GO:0060061 Spemann organizer formation(GO:0060061)
0.0 0.8 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 1.0 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.0 1.3 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 2.3 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.0 1.9 GO:0007098 centrosome cycle(GO:0007098)
0.0 0.8 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 1.3 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 0.7 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 1.6 GO:0050919 negative chemotaxis(GO:0050919)
0.0 0.7 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 1.1 GO:0002224 toll-like receptor signaling pathway(GO:0002224)
0.0 1.5 GO:0051028 mRNA transport(GO:0051028)
0.0 0.1 GO:0061549 sympathetic ganglion development(GO:0061549)
0.0 1.7 GO:0090305 nucleic acid phosphodiester bond hydrolysis(GO:0090305)
0.0 0.7 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 0.2 GO:0019233 sensory perception of pain(GO:0019233)
0.0 0.3 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 1.4 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.0 5.9 GO:0006412 translation(GO:0006412)
0.0 1.7 GO:0001756 somitogenesis(GO:0001756)
0.0 0.1 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 29.5 GO:0035556 intracellular signal transduction(GO:0035556)
0.0 0.3 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.3 GO:0000154 rRNA modification(GO:0000154)
0.0 0.3 GO:0030574 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.0 0.8 GO:0060027 convergent extension involved in gastrulation(GO:0060027)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 5.8 GO:0034359 mature chylomicron(GO:0034359)
0.4 1.4 GO:0017177 glucosidase II complex(GO:0017177)
0.3 1.9 GO:0031258 lamellipodium membrane(GO:0031258)
0.2 5.6 GO:0060170 ciliary membrane(GO:0060170)
0.2 1.6 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.2 0.7 GO:0031673 H zone(GO:0031673)
0.2 1.1 GO:0005913 cell-cell adherens junction(GO:0005913) zonula adherens(GO:0005915)
0.2 1.4 GO:0034719 SMN-Sm protein complex(GO:0034719)
0.2 2.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 0.4 GO:0034457 Mpp10 complex(GO:0034457)
0.1 1.2 GO:0000796 condensin complex(GO:0000796)
0.1 0.4 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 0.7 GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 0.8 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 4.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 0.8 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.1 0.7 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 1.0 GO:0030667 secretory granule membrane(GO:0030667)
0.0 0.5 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 2.0 GO:0030175 filopodium(GO:0030175)
0.0 4.4 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 2.5 GO:0005604 basement membrane(GO:0005604)
0.0 1.5 GO:0005776 autophagosome(GO:0005776)
0.0 0.1 GO:0005655 nucleolar ribonuclease P complex(GO:0005655)
0.0 0.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.7 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 5.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 3.2 GO:0005840 ribosome(GO:0005840)
0.0 0.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 2.8 GO:0048471 perinuclear region of cytoplasm(GO:0048471)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.2 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.7 2.1 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.7 6.0 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.6 5.8 GO:0070325 low-density lipoprotein particle receptor binding(GO:0050750) lipoprotein particle receptor binding(GO:0070325)
0.5 4.3 GO:0072518 Rho-dependent protein serine/threonine kinase activity(GO:0072518)
0.5 2.0 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.5 1.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.4 4.4 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.4 2.3 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.4 3.0 GO:0016803 ether hydrolase activity(GO:0016803)
0.4 1.1 GO:0070097 delta-catenin binding(GO:0070097)
0.3 0.9 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.3 3.7 GO:0070697 activin receptor binding(GO:0070697)
0.2 1.0 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.2 0.6 GO:0004377 GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity(GO:0004377)
0.2 3.1 GO:0030544 Hsp70 protein binding(GO:0030544)
0.2 0.6 GO:0000810 diacylglycerol diphosphate phosphatase activity(GO:0000810)
0.2 1.6 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.2 0.5 GO:0005502 11-cis retinal binding(GO:0005502)
0.2 1.4 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.2 0.7 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.2 3.1 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 0.6 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.1 2.5 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 6.3 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 3.7 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 2.6 GO:0005003 ephrin receptor activity(GO:0005003)
0.1 1.4 GO:0005222 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.1 1.6 GO:0048495 Roundabout binding(GO:0048495)
0.1 1.3 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.1 0.5 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 0.3 GO:0015350 reduced folate carrier activity(GO:0008518) methotrexate transporter activity(GO:0015350)
0.1 5.3 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.1 0.9 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 1.4 GO:0045134 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.1 1.0 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 2.2 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 3.0 GO:0015459 potassium channel regulator activity(GO:0015459)
0.1 2.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.7 GO:0003834 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.1 0.9 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 1.2 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.1 1.5 GO:0008252 nucleotidase activity(GO:0008252)
0.1 1.1 GO:0005080 protein kinase C binding(GO:0005080)
0.1 1.0 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.1 0.9 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.8 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 3.1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 0.7 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.7 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 7.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 1.9 GO:0005178 integrin binding(GO:0005178)
0.0 1.8 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 0.8 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.4 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.4 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.1 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.0 1.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.0 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.3 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 1.0 GO:0003678 DNA helicase activity(GO:0003678)
0.0 0.3 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.7 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.1 GO:0042171 lysophosphatidic acid acyltransferase activity(GO:0042171)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.2 4.9 PID GLYPICAN 1PATHWAY Glypican 1 network
0.2 1.5 ST G ALPHA S PATHWAY G alpha s Pathway
0.1 2.3 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.1 1.6 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.1 1.5 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 1.6 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.8 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 2.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.4 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 3.6 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.2 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.9 PID CDC42 PATHWAY CDC42 signaling events
0.0 1.5 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.7 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.4 1.5 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.2 1.4 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.2 2.1 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 1.9 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.0 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 1.1 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.1 0.5 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.1 2.1 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 0.5 REACTOME OPSINS Genes involved in Opsins
0.1 1.6 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 0.7 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 1.3 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 1.5 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 1.2 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.9 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 6.0 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.8 REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION Genes involved in Nuclear Events (kinase and transcription factor activation)
0.0 1.4 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 3.0 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.5 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 2.3 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism
0.0 1.4 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 0.6 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.9 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis