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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for pitx1+pitx3

Z-value: 0.51

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Transcription factors associated with pitx1+pitx3

Gene Symbol Gene ID Gene Info
pitx3
ENSDARG00000070069 paired-like homeodomain 3
pitx1
ENSDARG00000116608 paired-like homeodomain 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pitx1dr11_v1_chr21_+_45819662_458197290.372.6e-04Click!
pitx3dr11_v1_chr13_-_7573670_75736700.171.1e-01Click!

Activity profile of pitx1+pitx3 motif

Sorted Z-values of pitx1+pitx3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_33151246 5.78 ENSDART00000162681
rbfox3a
RNA binding fox-1 homolog 3a
chr23_-_28141419 5.16 ENSDART00000133039
tac3a
tachykinin 3a
chr25_+_21832938 4.96 ENSDART00000148299
ckmt1
creatine kinase, mitochondrial 1
chr13_+_15838151 4.37 ENSDART00000008987
klc1a
kinesin light chain 1a
chr2_-_32738535 3.80 ENSDART00000135293
nrbp2a
nuclear receptor binding protein 2a
chr24_-_38079261 3.51 ENSDART00000105662
crp1
C-reactive protein 1
chr5_-_16983336 3.34 ENSDART00000038740
galnt9
polypeptide N-acetylgalactosaminyltransferase 9
chr23_-_32334208 3.24 ENSDART00000053472
rnf41
ring finger protein 41
chr20_+_38525567 3.06 ENSDART00000147787
znf512
zinc finger protein 512
chr17_+_25289431 2.58 ENSDART00000161002
kbtbd11
kelch repeat and BTB (POZ) domain containing 11
chr4_-_77432218 2.51 ENSDART00000158683
slco1d1
solute carrier organic anion transporter family, member 1D1
chr25_-_8030425 2.43 ENSDART00000014964
camk1db
calcium/calmodulin-dependent protein kinase 1Db
chr7_+_57866292 2.41 ENSDART00000138757
camk2d1
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1
chr6_-_14040136 2.26 ENSDART00000065361
ENSDART00000179765
etv5b
ets variant 5b
chr21_+_1143141 2.04 ENSDART00000178294
CABZ01086139.1

chr18_+_7639401 1.94 ENSDART00000092416
rabl2
RAB, member of RAS oncogene family-like 2
chr11_-_29563437 1.80 ENSDART00000163958
arhgef10la
Rho guanine nucleotide exchange factor (GEF) 10-like a
chr3_+_15296824 1.74 ENSDART00000043801
cabp5b
calcium binding protein 5b
chr4_-_5077158 1.67 ENSDART00000155915
ahcyl2
adenosylhomocysteinase-like 2
chr8_+_23105117 1.62 ENSDART00000025171
ythdf1
YTH N(6)-methyladenosine RNA binding protein 1
chr9_-_40935934 1.55 ENSDART00000155604
C2orf88
Small membrane A-kinase anchor protein
chr4_+_10365857 1.53 ENSDART00000138890
kcnd2
potassium voltage-gated channel, Shal-related subfamily, member 2
chr25_-_8030113 1.52 ENSDART00000104674
camk1db
calcium/calmodulin-dependent protein kinase 1Db
chr15_-_15469079 1.42 ENSDART00000132637
ENSDART00000004220
rab34a
RAB34, member RAS oncogene family a
chr2_-_32505091 1.38 ENSDART00000141884
ENSDART00000056639
faim2a
Fas apoptotic inhibitory molecule 2a
chr19_-_10207103 1.35 ENSDART00000151629
znf865
zinc finger protein 865
chr7_+_38962459 1.32 ENSDART00000173851
dgkza
diacylglycerol kinase, zeta a
chr18_+_3022188 1.29 ENSDART00000170004
CU570791.1

chr10_-_25628555 1.23 ENSDART00000143978
tiam1a
T cell lymphoma invasion and metastasis 1a
chr5_-_28606916 1.22 ENSDART00000026107
ENSDART00000137717
tnc
tenascin C
chr2_-_48171441 1.20 ENSDART00000123040
pfkpb
phosphofructokinase, platelet b
chr14_+_6423973 1.18 ENSDART00000051556
abca1b
ATP-binding cassette, sub-family A (ABC1), member 1B
chr23_+_22335407 1.14 ENSDART00000147696
rap1gap
RAP1 GTPase activating protein
chr12_+_27213733 1.13 ENSDART00000133048
nbr1a
neighbor of brca1 gene 1a
chr15_-_45510977 1.12 ENSDART00000090596
fgf12b
fibroblast growth factor 12b
chr16_+_3067134 1.09 ENSDART00000012048
cyb5r4
cytochrome b5 reductase 4
chr5_+_59494079 0.99 ENSDART00000148727
gtf2ird1
GTF2I repeat domain containing 1
chr8_+_694218 0.97 ENSDART00000147753
rnf165b
ring finger protein 165b
chr8_+_23356264 0.96 ENSDART00000145062
dnmt3ba
DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a
chr8_+_16990120 0.93 ENSDART00000018934
pde4d
phosphodiesterase 4D, cAMP-specific
chr7_+_53413445 0.90 ENSDART00000190480
znf609b
zinc finger protein 609b
chr1_-_30762264 0.89 ENSDART00000085454
dis3
DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
chr20_+_38524827 0.84 ENSDART00000153021
znf512
zinc finger protein 512
chr15_+_11693624 0.84 ENSDART00000193630
ENSDART00000161930
strn4
striatin, calmodulin binding protein 4
chr22_+_26703026 0.83 ENSDART00000158756
crebbpa
CREB binding protein a
chr1_+_33383644 0.81 ENSDART00000187194
dhrsx
dehydrogenase/reductase (SDR family) X-linked
chr10_-_43294933 0.78 ENSDART00000062631
hapln1b
hyaluronan and proteoglycan link protein 1b
chr17_+_16046314 0.76 ENSDART00000154554
ENSDART00000154338
ENSDART00000155336
si:ch73-204p21.2
si:ch73-204p21.2
chr3_-_33175583 0.70 ENSDART00000126022
rarab
retinoic acid receptor, alpha b
chr5_+_60919378 0.67 ENSDART00000184915
doc2b
double C2-like domains, beta
chr16_-_25663846 0.66 ENSDART00000031304
derl1
derlin 1
chr15_+_5973909 0.61 ENSDART00000126886
ENSDART00000189618
igsf5b
immunoglobulin superfamily, member 5b
chr15_-_8856785 0.61 ENSDART00000192816
rab4b
RAB4B, member RAS oncogene family
chr8_+_21010850 0.58 ENSDART00000100295
si:dkeyp-82a1.4
si:dkeyp-82a1.4
chr1_+_56180416 0.58 ENSDART00000089358
crb3b
crumbs homolog 3b
chr9_+_30633184 0.58 ENSDART00000191310
tbc1d4
TBC1 domain family, member 4
chr6_+_41554794 0.54 ENSDART00000165424
srgap3
SLIT-ROBO Rho GTPase activating protein 3
chr10_+_6013076 0.50 ENSDART00000167613
ENSDART00000159216
hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr10_-_10016348 0.46 ENSDART00000129151
strbp
spermatid perinuclear RNA binding protein
chr18_+_13203831 0.44 ENSDART00000032151
cotl1
coactosin-like F-actin binding protein 1
chr1_+_33322555 0.39 ENSDART00000113486
mxra5a
matrix-remodelling associated 5a
chr19_+_2631565 0.35 ENSDART00000171487
fam126a
family with sequence similarity 126, member A
chr10_+_25204626 0.31 ENSDART00000024514
chordc1b
cysteine and histidine-rich domain (CHORD) containing 1b
chr11_-_27778831 0.31 ENSDART00000023823
cass4
Cas scaffolding protein family member 4
chr17_+_16046132 0.25 ENSDART00000155005
si:ch73-204p21.2
si:ch73-204p21.2
chr15_-_8309207 0.24 ENSDART00000143880
ENSDART00000061351
tnfrsf19
tumor necrosis factor receptor superfamily, member 19
chr6_+_8079974 0.24 ENSDART00000152071
si:ch211-207j7.2
si:ch211-207j7.2
chr15_-_14467394 0.24 ENSDART00000191944
numbl
numb homolog (Drosophila)-like
chr17_-_31308658 0.17 ENSDART00000124505
bahd1
bromo adjacent homology domain containing 1
chr14_+_1124409 0.16 ENSDART00000190043
ENSDART00000106708
ENSDART00000160246
sec24b
SEC24 homolog B, COPII coat complex component
chr20_+_29587995 0.16 ENSDART00000153339
adam17b
ADAM metallopeptidase domain 17b
chr23_+_7505943 0.13 ENSDART00000135787
hck
HCK proto-oncogene, Src family tyrosine kinase
chr7_-_17779644 0.11 ENSDART00000128504
si:dkey-106g10.7
si:dkey-106g10.7
chr3_-_33574576 0.07 ENSDART00000184881
CR847537.1

chr24_-_20321012 0.07 ENSDART00000163683
map3k20
mitogen-activated protein kinase kinase kinase 20
chr21_+_33172526 0.07 ENSDART00000183532
arl3l1
ADP-ribosylation factor-like 3, like 1
chr15_+_45640906 0.04 ENSDART00000149361
ENSDART00000149079
sagb
S-antigen; retina and pineal gland (arrestin) b
chr21_-_14310159 0.01 ENSDART00000155097
si:ch211-196i2.1
si:ch211-196i2.1

Network of associatons between targets according to the STRING database.

First level regulatory network of pitx1+pitx3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 5.2 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.4 1.2 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582) axon regeneration at neuromuscular junction(GO:0014814) positive regulation of synaptic growth at neuromuscular junction(GO:0045887)
0.4 5.0 GO:0006599 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.2 1.4 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.2 0.5 GO:1902767 farnesyl diphosphate biosynthetic process, mevalonate pathway(GO:0010142) isoprenoid biosynthetic process via mevalonate(GO:1902767)
0.2 2.3 GO:0035108 hypothalamus cell differentiation(GO:0021979) limb morphogenesis(GO:0035108)
0.1 1.8 GO:0032933 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.1 1.6 GO:0050779 RNA destabilization(GO:0050779) mRNA destabilization(GO:0061157)
0.1 2.5 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 1.2 GO:0033700 phospholipid efflux(GO:0033700)
0.1 1.1 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 5.8 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 0.3 GO:0090527 actin filament reorganization(GO:0090527)
0.1 0.7 GO:0003139 secondary heart field specification(GO:0003139)
0.1 1.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1 0.6 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.1 0.9 GO:0016075 rRNA catabolic process(GO:0016075)
0.1 0.7 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.2 GO:0014045 establishment of endothelial blood-brain barrier(GO:0014045)
0.0 0.9 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 3.2 GO:0030318 melanocyte differentiation(GO:0030318)
0.0 1.1 GO:0006801 superoxide metabolic process(GO:0006801)
0.0 0.4 GO:0006007 glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.0 4.0 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 1.0 GO:0006305 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 3.0 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.6 GO:0032482 Rab protein signal transduction(GO:0032482)
0.0 4.0 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 0.7 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.0 0.3 GO:0010824 regulation of centrosome duplication(GO:0010824)
0.0 3.3 GO:0006486 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.2 GO:0071782 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.1 0.7 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 0.9 GO:0000177 nuclear exosome (RNase complex)(GO:0000176) cytoplasmic exosome (RNase complex)(GO:0000177)
0.1 0.6 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 4.4 GO:0005871 kinesin complex(GO:0005871)
0.0 1.1 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.4 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 1.5 GO:0043204 perikaryon(GO:0043204)
0.0 0.4 GO:0030864 cortical actin cytoskeleton(GO:0030864)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.5 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.4 5.0 GO:0016775 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.3 1.6 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.3 1.5 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.2 1.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012) phosphatidylcholine-translocating ATPase activity(GO:0090554) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.2 0.7 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.2 0.5 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.2 1.1 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 0.8 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 6.4 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 1.0 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 1.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 1.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.9 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.4 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.9 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.8 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 1.1 GO:0043130 ubiquitin binding(GO:0043130)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 3.2 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.6 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.2 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 1.1 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 3.3 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.1 0.9 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 0.9 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 1.5 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.5 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.2 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.5 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor