Project

PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

Navigation
Downloads

Results for pknox2

Z-value: 0.76

Motif logo

Transcription factors associated with pknox2

Gene Symbol Gene ID Gene Info
ENSDARG00000055349 pbx/knotted 1 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pknox2dr11_v1_chr10_-_31104983_311049830.659.1e-13Click!

Activity profile of pknox2 motif

Sorted Z-values of pknox2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_36260102 9.56 ENSDART00000126588
Rac family small GTPase 3a
chr6_+_14949950 9.18 ENSDART00000149202
ENSDART00000149949
POU class 3 homeobox 3b
chr11_-_32723851 8.55 ENSDART00000155592
protocadherin 17
chr22_-_23253481 8.47 ENSDART00000054807
LIM homeobox 9
chr1_-_14234076 7.43 ENSDART00000040049
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2
chr6_+_38381957 7.34 ENSDART00000087300
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr19_-_9712530 6.89 ENSDART00000134816
solute carrier family 2 (facilitated glucose transporter), member 3a
chr22_-_23253252 6.63 ENSDART00000175556
LIM homeobox 9
chr1_-_14233815 6.46 ENSDART00000044896
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2
chr9_+_6009077 6.43 ENSDART00000057484
ST6 beta-galactosamide alpha-2,6-sialyltranferase 2a
chr8_-_33114202 6.36 ENSDART00000098840
Ral GEF with PH domain and SH3 binding motif 1
chr20_+_28434196 5.90 ENSDART00000034245
D4, zinc and double PHD fingers, family 3
chr16_+_11151699 5.83 ENSDART00000140674
capicua transcriptional repressor b
chr12_+_17504559 5.38 ENSDART00000020628
cytohesin 3a
chr5_-_46273938 5.28 ENSDART00000080033
si:ch211-130m23.3
chr11_+_28218141 5.26 ENSDART00000043756
eph receptor B2b
chr13_+_32446169 5.23 ENSDART00000143325
5'-nucleotidase, cytosolic IB a
chr5_-_18911114 5.22 ENSDART00000014434
bri3 binding protein
chr5_+_15667874 5.11 ENSDART00000127015
serine/arginine repetitive matrix 4
chr11_+_40649412 5.00 ENSDART00000043016
ENSDART00000134560
solute carrier family 45, member 1
chr10_+_37500234 4.86 ENSDART00000132096
ENSDART00000099473
musashi RNA-binding protein 2a
chr4_-_17629444 4.76 ENSDART00000108814
nuclear receptor interacting protein 2
chr21_+_38312549 4.72 ENSDART00000065159
zgc:158291
chr21_-_34658266 4.69 ENSDART00000023038
dachshund a
chr4_-_20081621 4.65 ENSDART00000024647
DENN/MADD domain containing 6B
chr20_+_26095530 4.59 ENSDART00000139350
spectrin repeat containing, nuclear envelope 1a
chr7_-_28565230 4.40 ENSDART00000028887
TMEM9 domain family, member B
chr5_+_57743815 4.38 ENSDART00000005090
ALG9, alpha-1,2-mannosyltransferase
chr21_+_39336285 4.30 ENSDART00000139677
si:ch211-274p24.4
chr19_+_42693855 4.30 ENSDART00000136873
cytoplasmic linker associated protein 2
chr15_+_16897554 4.29 ENSDART00000154679
yippee-like 2b
chr10_+_25982212 4.28 ENSDART00000128292
ENSDART00000108808
Fras1 related extracellular matrix protein 2a
chr3_-_16039619 4.22 ENSDART00000143324
splA/ryanodine receptor domain and SOCS box containing 3a
chr18_+_22793743 4.15 ENSDART00000150106
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a
chr20_-_28433990 4.07 ENSDART00000182824
ENSDART00000193381
WD repeat domain 21
chr23_-_29667544 4.00 ENSDART00000059339
calsyntenin 1
chr20_-_39188476 3.84 ENSDART00000152858
regulator of calcineurin 2
chr16_-_563235 3.82 ENSDART00000016303
iroquois homeobox 2a
chr14_+_49152341 3.78 ENSDART00000084114
nuclear receptor binding SET domain protein 1a
chr5_+_19320554 3.74 ENSDART00000165119
RUN and SH3 domain containing 2
chr3_-_40836081 3.72 ENSDART00000143135
WD repeat domain, phosphoinositide interacting 2
chr16_+_13855039 3.67 ENSDART00000113764
ENSDART00000143983
zgc:174888
chr20_-_47731768 3.66 ENSDART00000031167
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr5_-_13766651 3.55 ENSDART00000134064
MAX dimerization protein 1
chr3_+_28576173 3.52 ENSDART00000151189
septin 12
chr8_+_25959940 3.47 ENSDART00000143011
ENSDART00000140626
si:dkey-72l14.4
chr3_-_15227666 3.41 ENSDART00000065807
potassium channel tetramerization domain containing 13
chr5_-_60159116 3.40 ENSDART00000147675
si:dkey-280e8.1
chr5_-_32489796 3.28 ENSDART00000168870
G protein-coupled receptor 107
chr7_-_19369002 3.26 ENSDART00000165680
netrin 4
chr4_+_9279784 3.22 ENSDART00000014897
SLIT-ROBO Rho GTPase activating protein 1b
chr22_-_21046654 3.22 ENSDART00000064902
single stranded DNA binding protein 4
chr2_-_32558795 3.18 ENSDART00000140026
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3a
chr10_-_43029001 3.14 ENSDART00000171494
single-stranded DNA binding protein 2
chr5_-_12219572 3.14 ENSDART00000167834
nitric oxide synthase 1 (neuronal)
chr2_+_38742338 3.11 ENSDART00000177290
capping protein regulator and myosin 1 linker 3
chr17_+_23964132 3.05 ENSDART00000154823
exportin 1 (CRM1 homolog, yeast) b
chr6_+_43903209 3.01 ENSDART00000006435
G protein-coupled receptor 27
chr20_-_27857676 2.98 ENSDART00000192934
synapse differentiation inducing 1-like
chr5_+_27137473 2.89 ENSDART00000181833
unc-5 netrin receptor Db
chr6_-_39160422 2.87 ENSDART00000148661
signal transducer and activator of transcription 2
chr5_-_23675222 2.70 ENSDART00000135153
si:dkey-110k5.6
chr7_-_26262978 2.69 ENSDART00000137769
adaptor-related protein complex 1, sigma 1 subunit
chr19_+_41075488 2.60 ENSDART00000138687
protein phosphatase 1, regulatory subunit 9A
chr20_-_28433616 2.58 ENSDART00000169289
WD repeat domain 21
chr4_+_4267451 2.52 ENSDART00000192069
anoctamin 2
chr11_-_843811 2.49 ENSDART00000173331
ATG7 autophagy related 7 homolog (S. cerevisiae)
chr10_+_42521943 2.49 ENSDART00000010420
ENSDART00000075303
ARP1 actin related protein 1, centractin
chr17_-_14780578 2.48 ENSDART00000154690
si:ch211-266o15.1
chr7_-_68373495 2.47 ENSDART00000167440
zinc finger homeobox 3
chr3_-_23596532 2.42 ENSDART00000124921
ubiquitin-conjugating enzyme E2Z
chr23_-_4019928 2.40 ENSDART00000021062
solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
chr15_-_46718759 2.36 ENSDART00000085926
ENSDART00000154577
zgc:162872
chr19_-_25427255 2.30 ENSDART00000036854
glucocorticoid induced 1a
chr10_+_10738880 2.30 ENSDART00000004181
solute carrier family 27 (fatty acid transporter), member 4
chr7_-_26263183 2.28 ENSDART00000079357
ENSDART00000190369
ENSDART00000193154
ENSDART00000101109
adaptor-related protein complex 1, sigma 1 subunit
chr5_-_17601759 2.28 ENSDART00000138387
si:ch211-130h14.6
chr13_+_22712406 2.28 ENSDART00000132847
si:ch211-134m17.9
chr18_-_26126258 2.21 ENSDART00000145875
ankyrin repeat domain 34C
chr23_+_25893020 2.19 ENSDART00000144769
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr3_-_16055432 2.16 ENSDART00000123621
ENSDART00000023859
ATPase H+ transporting V0 subunit ca
chr8_+_44623540 2.15 ENSDART00000141513
G protein-coupled receptor kinase 5 like
chr4_+_26056548 2.10 ENSDART00000171204
si:ch211-244b2.1
chr11_+_38280454 2.03 ENSDART00000171496
si:dkey-166c18.1
chr3_-_23596809 2.00 ENSDART00000156897
ubiquitin-conjugating enzyme E2Z
chr12_+_28854963 1.96 ENSDART00000153227
nuclear factor, erythroid 2-like 1b
chr6_+_41452979 1.91 ENSDART00000007353
WD repeat domain 82
chr18_+_17786548 1.88 ENSDART00000189493
ENSDART00000146133
si:ch211-216l23.1
chr4_+_9279515 1.87 ENSDART00000048707
SLIT-ROBO Rho GTPase activating protein 1b
chr22_-_17574511 1.86 ENSDART00000181496
phosphatidylinositol-4-phosphate 5-kinase, type I, gamma a
chr24_+_33392698 1.76 ENSDART00000122579
si:ch73-173p19.1
chr10_+_36695597 1.75 ENSDART00000169015
ENSDART00000171392
RAB6A, member RAS oncogene family
chr2_-_11027258 1.69 ENSDART00000081072
ENSDART00000193824
ENSDART00000187036
ENSDART00000097741
single stranded DNA binding protein 3a
chr11_+_44503774 1.67 ENSDART00000169295
endoplasmic reticulum oxidoreductase beta
chr2_-_41723165 1.60 ENSDART00000155577
zgc:110158
chr23_-_4019699 1.54 ENSDART00000159780
solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
chr19_-_6134802 1.52 ENSDART00000140051
capicua transcriptional repressor a
chr20_+_32478151 1.50 ENSDART00000145269
osteopetrosis associated transmembrane protein 1
chr3_+_40315410 1.49 ENSDART00000083241
ENSDART00000132827
solute carrier family 29 (equilibrative nucleoside transporter), member 4
chr22_+_2417105 1.46 ENSDART00000106415
zgc:113220
chr12_+_36971952 1.43 ENSDART00000125900
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1b
chr5_-_41124241 1.41 ENSDART00000083561
myotubularin related protein 12
chr17_+_33999630 1.38 ENSDART00000167085
ENSDART00000155030
ENSDART00000168522
ENSDART00000191799
ENSDART00000189684
ENSDART00000153942
ENSDART00000187272
ENSDART00000127692
gephyrin a
chr12_-_36740781 1.36 ENSDART00000105484
si:ch211-216b21.2
chr24_-_34034931 1.33 ENSDART00000169227
acid-sensing (proton-gated) ion channel 1c
chr2_-_38117538 1.33 ENSDART00000013676
chromodomain helicase DNA binding protein 8
chr5_-_69437422 1.32 ENSDART00000073676
iron-sulfur cluster assembly 1
chr16_-_563732 1.31 ENSDART00000183394
iroquois homeobox 2a
chr7_-_29723761 1.29 ENSDART00000173560
vacuolar protein sorting 13 homolog C (S. cerevisiae)
chr4_+_25693463 1.29 ENSDART00000132864
acyl-CoA thioesterase 18
chr11_+_2506516 1.28 ENSDART00000130886
ENSDART00000189767
si:ch73-190f16.2
chr12_-_33659328 1.28 ENSDART00000153457
transmembrane protein 94
chr1_+_19849168 1.24 ENSDART00000111454
si:dkey-82j4.2
chr2_+_3696038 1.20 ENSDART00000150499
ENSDART00000136906
ENSDART00000164152
ENSDART00000128514
ENSDART00000108964
epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
chr18_+_17786710 1.17 ENSDART00000190203
ENSDART00000187095
ENSDART00000083296
si:ch211-216l23.1
chr23_-_21758253 1.16 ENSDART00000046613
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr2_-_41723487 1.15 ENSDART00000170171
zgc:110158
chr24_-_21511737 1.14 ENSDART00000109587
ring finger protein (C3H2C3 type) 6
chr7_+_73332486 1.13 ENSDART00000174119
ENSDART00000092051
ENSDART00000192388

chr3_-_20793655 1.09 ENSDART00000163473
ENSDART00000159457
speckle-type POZ protein
chr15_+_23528010 1.08 ENSDART00000152786
si:dkey-182i3.8
chr7_-_56766973 1.07 ENSDART00000020967
casein kinase 2, alpha prime polypeptide a
chr15_+_23528310 1.07 ENSDART00000152523
si:dkey-182i3.8
chr12_+_48204891 1.06 ENSDART00000190534
ENSDART00000164427
nodal-related 2
chr20_-_20270191 1.03 ENSDART00000009356
protein phosphatase 2, regulatory subunit B', epsilon isoform a
chr16_+_48714048 1.00 ENSDART00000148709
ENSDART00000150121
bromodomain containing 2b
chr3_-_15889508 0.97 ENSDART00000148363
cramped chromatin regulator homolog 1
chr11_+_5880562 0.92 ENSDART00000129663
ENSDART00000130768
ENSDART00000160909
DAZ associated protein 1
chr2_+_30489846 0.92 ENSDART00000145732
membrane-associated ring finger (C3HC4) 6
chr14_-_32893785 0.91 ENSDART00000169380
solute carrier family 25, member 43
chr6_+_58915889 0.89 ENSDART00000083628
DNA-damage-inducible transcript 3
chr8_+_30425700 0.83 ENSDART00000012132
COBW domain containing
chr22_-_21046843 0.83 ENSDART00000133982
single stranded DNA binding protein 4
chr17_-_11418513 0.82 ENSDART00000064412
ENSDART00000151847
AT rich interactive domain 4A (RBP1-like)
chr19_-_30800004 0.81 ENSDART00000128560
ENSDART00000045504
ENSDART00000125893
tRNA isopentenyltransferase 1
chr5_-_13645995 0.80 ENSDART00000099665
ENSDART00000166957
purine-rich element binding protein Ba
chr10_+_11355841 0.77 ENSDART00000193067
ENSDART00000064215
COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)
chr16_+_40575742 0.73 ENSDART00000161503
cyclin E2
chr7_+_30725473 0.71 ENSDART00000085716
myotubularin related protein 10
chr22_-_22231720 0.68 ENSDART00000160165
adaptor-related protein complex 3, delta 1 subunit
chr24_+_10413484 0.65 ENSDART00000111014
MYC proto-oncogene, bHLH transcription factor a
chr16_+_44768361 0.56 ENSDART00000036302
uroplakin 1a
chr7_-_56766100 0.54 ENSDART00000189934
casein kinase 2, alpha prime polypeptide a
chr16_-_13595027 0.53 ENSDART00000060004
ntl-dependent gene 5
chr6_+_23931236 0.52 ENSDART00000166079
growth arrest and DNA-damage-inducible, alpha, b
chr9_-_12885201 0.52 ENSDART00000124957
ankyrin repeat and zinc finger domain containing 1
chr12_+_18899396 0.50 ENSDART00000105858
X-ray repair complementing defective repair in Chinese hamster cells 6
chr7_-_37555208 0.49 ENSDART00000148905
ENSDART00000150229
cylindromatosis (turban tumor syndrome), a
chr13_-_18011168 0.49 ENSDART00000144813
membrane-associated ring finger (C3HC4) 8
chr19_-_81477 0.47 ENSDART00000159815
heterogeneous nuclear ribonucleoprotein R
chr14_-_689841 0.45 ENSDART00000125969
ubiquitin-conjugating enzyme E2Ka (UBC1 homolog, yeast)
chr20_+_26690036 0.38 ENSDART00000103232
forkhead box F2b
chr12_+_3871452 0.37 ENSDART00000066546
NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)
chr19_+_25465025 0.27 ENSDART00000018553
replication protein A3
chr22_-_20720427 0.25 ENSDART00000105532
ornithine decarboxylase antizyme 1a
chr25_+_14870043 0.25 ENSDART00000035714
ENSDART00000171835
DnaJ (Hsp40) homolog, subfamily C, member 24
chr17_+_27158706 0.22 ENSDART00000151829
ribosomal protein S6 kinase a, polypeptide 1
chr7_+_52761841 0.16 ENSDART00000111444
diphosphoinositol pentakisphosphate kinase 1a
chr23_+_24705424 0.14 ENSDART00000104029
C1q and TNF related 12
chr15_-_20528494 0.14 ENSDART00000048423
translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
chr3_+_13190012 0.12 ENSDART00000179747
ENSDART00000109876
ENSDART00000124824
ENSDART00000130261
Sad1 and UNC84 domain containing 1
chr17_-_23673864 0.11 ENSDART00000104738
ENSDART00000128958
phosphatase and tensin homolog A
chr23_+_33963619 0.10 ENSDART00000140666
ENSDART00000084792
pyridoxal phosphate binding protein
chr3_-_25646149 0.01 ENSDART00000122735
ubiquitin specific peptidase 43b

Network of associatons between targets according to the STRING database.

First level regulatory network of pknox2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 15.1 GO:0097378 interneuron axon guidance(GO:0097376) spinal cord interneuron axon guidance(GO:0097377) dorsal spinal cord interneuron axon guidance(GO:0097378)
1.0 3.1 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923) retrograde trans-synaptic signaling by nitric oxide(GO:0098924)
1.0 4.0 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.6 1.9 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.5 1.4 GO:0042040 establishment of synaptic specificity at neuromuscular junction(GO:0007529) molybdenum incorporation into molybdenum-molybdopterin complex(GO:0018315) metal incorporation into metallo-molybdopterin complex(GO:0042040) glycine receptor clustering(GO:0072579)
0.4 5.2 GO:0046085 adenosine metabolic process(GO:0046085)
0.4 5.1 GO:0021754 facial nucleus development(GO:0021754)
0.4 2.2 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.4 2.5 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.4 3.2 GO:0032986 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.4 2.5 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.3 3.1 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.3 8.7 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.3 2.3 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.3 3.7 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.3 5.1 GO:0035778 pronephric nephron tubule epithelial cell differentiation(GO:0035778) cell differentiation involved in pronephros development(GO:0039014) nephron tubule epithelial cell differentiation(GO:0072160)
0.3 1.7 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.3 2.9 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.3 2.9 GO:0071357 response to type I interferon(GO:0034340) type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.2 2.2 GO:0060036 notochord cell vacuolation(GO:0060036)
0.2 0.9 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.2 1.1 GO:0001709 cell fate determination(GO:0001709)
0.2 3.5 GO:0032418 lysosome localization(GO:0032418)
0.2 1.3 GO:0070207 protein homotrimerization(GO:0070207)
0.2 1.3 GO:2000178 negative regulation of neural precursor cell proliferation(GO:2000178)
0.2 1.3 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.2 4.3 GO:0007020 microtubule nucleation(GO:0007020)
0.2 5.9 GO:0055008 cardiac muscle tissue morphogenesis(GO:0055008)
0.2 6.3 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.2 5.8 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.1 2.3 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.1 0.5 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.1 5.4 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 3.3 GO:0070831 basement membrane assembly(GO:0070831)
0.1 0.7 GO:0048490 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.1 2.1 GO:1902017 regulation of cilium assembly(GO:1902017)
0.1 0.5 GO:0071480 response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)
0.1 1.5 GO:0015858 nucleoside transport(GO:0015858) nucleoside transmembrane transport(GO:1901642)
0.1 4.2 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.1 7.3 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 1.2 GO:0072554 endothelial tube morphogenesis(GO:0061154) blood vessel lumenization(GO:0072554)
0.1 9.6 GO:0008360 regulation of cell shape(GO:0008360)
0.1 0.5 GO:1990108 protein linear deubiquitination(GO:1990108)
0.1 5.1 GO:0030336 negative regulation of cell migration(GO:0030336)
0.1 0.4 GO:0051145 smooth muscle cell differentiation(GO:0051145)
0.1 1.7 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.1 2.3 GO:0072015 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.1 3.0 GO:0033500 carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593)
0.1 6.4 GO:0019722 calcium-mediated signaling(GO:0019722)
0.1 0.5 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 0.9 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 1.0 GO:0002574 thrombocyte differentiation(GO:0002574)
0.0 1.0 GO:0031952 regulation of protein autophosphorylation(GO:0031952)
0.0 2.8 GO:0051453 regulation of intracellular pH(GO:0051453)
0.0 0.1 GO:0046324 regulation of glucose import(GO:0046324)
0.0 4.4 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 3.5 GO:0033334 fin morphogenesis(GO:0033334)
0.0 2.0 GO:0034599 cellular response to oxidative stress(GO:0034599)
0.0 6.4 GO:0006486 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
0.0 13.9 GO:0045944 positive regulation of transcription from RNA polymerase II promoter(GO:0045944)
0.0 4.7 GO:0048839 ear development(GO:0043583) inner ear development(GO:0048839)
0.0 1.3 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 1.6 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107) peptidyl-threonine modification(GO:0018210)
0.0 0.2 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.0 13.1 GO:0007420 brain development(GO:0007420)
0.0 2.2 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.0 5.0 GO:0030198 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0 1.7 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 1.4 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0 0.8 GO:0006400 tRNA modification(GO:0006400)
0.0 0.3 GO:0006596 polyamine biosynthetic process(GO:0006596)
0.0 0.7 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 4.3 GO:0042127 regulation of cell proliferation(GO:0042127)
0.0 3.6 GO:0032259 methylation(GO:0032259)
0.0 0.2 GO:0006020 inositol metabolic process(GO:0006020)
0.0 2.3 GO:0000122 negative regulation of transcription from RNA polymerase II promoter(GO:0000122)
0.0 0.3 GO:0006298 mismatch repair(GO:0006298)
0.0 4.4 GO:0043066 negative regulation of apoptotic process(GO:0043066)
0.0 4.0 GO:0007264 small GTPase mediated signal transduction(GO:0007264)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.7 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.4 9.1 GO:0071565 nBAF complex(GO:0071565)
0.3 4.6 GO:0005640 nuclear outer membrane(GO:0005640)
0.2 7.3 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.2 0.7 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
0.2 4.3 GO:0045180 basal cortex(GO:0045180)
0.2 4.9 GO:0005844 polysome(GO:0005844)
0.1 2.2 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1 4.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 2.5 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 1.6 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.1 2.4 GO:0005605 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.1 6.4 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 1.9 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.1 3.5 GO:0005940 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.1 2.6 GO:0035861 site of double-strand break(GO:0035861)
0.1 5.1 GO:0005684 U2-type spliceosomal complex(GO:0005684)
0.1 0.8 GO:0008180 COP9 signalosome(GO:0008180)
0.1 1.3 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 4.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 1.2 GO:0045178 basal part of cell(GO:0045178)
0.1 5.7 GO:0030117 membrane coat(GO:0030117) coated membrane(GO:0048475)
0.0 3.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 2.3 GO:0005902 microvillus(GO:0005902)
0.0 2.2 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 4.0 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 3.1 GO:0042383 sarcolemma(GO:0042383)
0.0 1.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 22.6 GO:0043005 neuron projection(GO:0043005)
0.0 5.6 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.1 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.1 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 3.6 GO:0000785 chromatin(GO:0000785)
0.0 1.1 GO:0055037 recycling endosome(GO:0055037)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.4 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.8 4.2 GO:0051430 mu-type opioid receptor binding(GO:0031852) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.8 6.4 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.6 3.8 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.6 5.0 GO:0008515 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.5 2.5 GO:0019778 Atg12 activating enzyme activity(GO:0019778) Atg8 activating enzyme activity(GO:0019779)
0.5 1.4 GO:0061598 molybdopterin adenylyltransferase activity(GO:0061598) molybdopterin molybdotransferase activity(GO:0061599)
0.4 3.1 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.4 1.2 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.4 2.2 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.4 3.9 GO:0015386 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.3 2.3 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.3 5.3 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.3 3.1 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.3 13.9 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.3 2.9 GO:0005042 netrin receptor activity(GO:0005042)
0.3 1.3 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.3 4.8 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.2 3.8 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.2 3.3 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.2 7.3 GO:0004890 GABA-A receptor activity(GO:0004890)
0.2 1.5 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
0.2 0.9 GO:0034046 poly(G) binding(GO:0034046)
0.2 1.2 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.2 3.6 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.2 3.7 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.2 15.9 GO:0003697 single-stranded DNA binding(GO:0003697)
0.2 1.1 GO:0070698 type I activin receptor binding(GO:0070698)
0.1 2.1 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.1 1.7 GO:0016671 protein disulfide isomerase activity(GO:0003756) oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 4.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 0.8 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 4.4 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 1.9 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 0.7 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 1.3 GO:0002039 p53 binding(GO:0002039)
0.1 0.3 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.1 1.0 GO:0019211 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.1 1.3 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.1 1.9 GO:0016307 phosphatidylinositol phosphate kinase activity(GO:0016307)
0.0 1.3 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.0 0.2 GO:0000829 inositol heptakisphosphate kinase activity(GO:0000829) diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.0 1.3 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.5 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 5.7 GO:0042393 histone binding(GO:0042393)
0.0 11.4 GO:0003924 GTPase activity(GO:0003924)
0.0 0.5 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 4.1 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.2 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.9 GO:0005347 ATP transmembrane transporter activity(GO:0005347)
0.0 5.7 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.5 GO:0042287 MHC protein binding(GO:0042287)
0.0 32.9 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 5.3 GO:0051015 actin filament binding(GO:0051015)
0.0 0.2 GO:0001671 ATPase activator activity(GO:0001671)
0.0 4.2 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 4.0 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.8 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.9 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.3 3.8 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 3.5 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 2.4 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.7 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 2.5 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.5 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 1.1 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.9 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.3 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 7.3 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.5 5.0 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.3 2.9 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.2 3.1 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.2 3.8 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 4.4 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 0.9 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 1.7 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 3.3 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 0.5 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.1 0.7 REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.1 2.7 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 8.0 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 2.8 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.3 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.2 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS Genes involved in CREB phosphorylation through the activation of Ras