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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for plag1+plagx

Z-value: 0.50

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Transcription factors associated with plag1+plagx

Gene Symbol Gene ID Gene Info
plagx
ENSDARG00000036855 pleiomorphic adenoma gene X
plag1
ENSDARG00000051926 pleiomorphic adenoma gene 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
plagxdr11_v1_chr23_+_32011768_32011768-0.278.4e-03Click!
plag1dr11_v1_chr7_+_58730201_58730201-0.251.5e-02Click!

Activity profile of plag1+plagx motif

Sorted Z-values of plag1+plagx motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_25916530 5.69 ENSDART00000186386
sncgb
synuclein, gamma b (breast cancer-specific protein 1)
chr21_+_7823146 5.08 ENSDART00000030579
crhbp
corticotropin releasing hormone binding protein
chr4_+_6572364 4.64 ENSDART00000122574
ppp1r3aa
protein phosphatase 1, regulatory subunit 3Aa
chr23_+_44732863 4.37 ENSDART00000160044
ENSDART00000172268
atp1b2a
ATPase Na+/K+ transporting subunit beta 2a
chr2_+_2470687 3.01 ENSDART00000184024
ENSDART00000061955
myl13
myosin, light chain 13
chr4_+_19534833 2.88 ENSDART00000140028
lrrc4.1
leucine rich repeat containing 4.1
chr16_-_36798783 2.77 ENSDART00000145697
calb1
calbindin 1
chr7_+_568819 2.61 ENSDART00000173716
nrxn2b
neurexin 2b
chr23_+_43954809 2.04 ENSDART00000164080
corin
corin, serine peptidase
chr4_+_9400012 1.90 ENSDART00000191960
tmtc1
transmembrane and tetratricopeptide repeat containing 1
chr6_-_35401282 1.86 ENSDART00000127612
rgs5a
regulator of G protein signaling 5a
chr11_+_13630107 1.83 ENSDART00000172220
si:ch211-1a19.3
si:ch211-1a19.3
chr7_-_38477235 1.82 ENSDART00000084355
zgc:165481
zgc:165481
chr20_-_14665002 1.50 ENSDART00000152816
scrn2
secernin 2
chr24_-_21490628 1.44 ENSDART00000181546
atp8a2
ATPase phospholipid transporting 8A2
chr22_-_15957041 1.42 ENSDART00000149236
ENSDART00000187500
ENSDART00000176304
ENSDART00000080047
ENSDART00000190068
eps15l1a
epidermal growth factor receptor pathway substrate 15-like 1a
chr19_-_4010263 1.37 ENSDART00000159605
ENSDART00000165541
map7d1b
MAP7 domain containing 1b
chr19_+_42336523 1.31 ENSDART00000151304
anp32e
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr14_-_1958994 1.17 ENSDART00000161783
pcdh2g5
protocadherin 2 gamma 5
chr14_-_2209742 1.11 ENSDART00000054889
pcdh2ab5
protocadherin 2 alpha b 5
chr4_+_21741228 0.94 ENSDART00000112035
ENSDART00000127664
myf5
myogenic factor 5
chr24_-_26383978 0.89 ENSDART00000031426
skilb
SKI-like proto-oncogene b
chr7_+_44608478 0.85 ENSDART00000149981
cmtm3
CKLF-like MARVEL transmembrane domain containing 3
chr21_+_13389499 0.83 ENSDART00000151268
zgc:113162
zgc:113162
chr7_+_44608224 0.82 ENSDART00000005033
cmtm3
CKLF-like MARVEL transmembrane domain containing 3
chr19_-_20093341 0.80 ENSDART00000129917
mpp6b
membrane protein, palmitoylated 6b (MAGUK p55 subfamily member 6)
chr15_-_915635 0.79 ENSDART00000179821
si:dkey-7i4.21
si:dkey-7i4.21
chr5_+_38886499 0.78 ENSDART00000076845
fras1
Fraser extracellular matrix complex subunit 1
chr8_+_25247245 0.74 ENSDART00000045798
ampd2b
adenosine monophosphate deaminase 2b
chr7_+_39399747 0.74 ENSDART00000147037
tnni2b.1
troponin I type 2b (skeletal, fast), tandem duplicate 1
chr14_-_21661015 0.70 ENSDART00000189403
ENSDART00000172442
ENSDART00000181913
kdm3b
lysine (K)-specific demethylase 3B
chr20_+_28245164 0.59 ENSDART00000103320
dll4
delta-like 4 (Drosophila)
chr5_+_63785339 0.49 ENSDART00000050871
rgs3b
regulator of G protein signaling 3b
chr7_-_41403022 0.45 ENSDART00000174285
BX322787.1

chr21_+_5801105 0.45 ENSDART00000151225
ENSDART00000184487
ccng2
cyclin G2
chr3_-_25420931 0.43 ENSDART00000109601
ENSDART00000182184
bptf
bromodomain PHD finger transcription factor
chr4_+_59320243 0.42 ENSDART00000150611
znf1084
zinc finger protein 1084
chr22_+_8551813 0.41 ENSDART00000129690
zmp:0000000984
zmp:0000000984
chr24_-_35534273 0.32 ENSDART00000026578
ube2v2
ubiquitin-conjugating enzyme E2 variant 2
chr3_-_34051363 0.31 ENSDART00000151768
ighv3-2
immunoglobulin heavy variable 3-2
chr10_-_36240806 0.28 ENSDART00000171468
or109-2
odorant receptor, family D, subfamily 109, member 2
chr12_+_22657925 0.27 ENSDART00000153048
si:dkey-219e21.4
si:dkey-219e21.4
chr24_+_42131564 0.22 ENSDART00000153854
wwp1
WW domain containing E3 ubiquitin protein ligase 1
chr21_-_21020708 0.21 ENSDART00000064032
eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
chr20_-_24183333 0.11 ENSDART00000025862
ENSDART00000153075
map3k7
mitogen-activated protein kinase kinase kinase 7
chr12_-_30345444 0.06 ENSDART00000152985
vwa2
von Willebrand factor A domain containing 2
chr6_+_52911338 0.05 ENSDART00000065710
si:dkeyp-3f10.14
si:dkeyp-3f10.14
chr7_-_59514547 0.04 ENSDART00000168457
slx1b
SLX1 homolog B, structure-specific endonuclease subunit

Network of associatons between targets according to the STRING database.

First level regulatory network of plag1+plagx

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.1 GO:0090278 negative regulation of peptide secretion(GO:0002792) negative regulation of peptide hormone secretion(GO:0090278)
0.7 2.8 GO:0099509 regulation of presynaptic cytosolic calcium ion concentration(GO:0099509) regulation of long-term synaptic potentiation(GO:1900271)
0.3 0.9 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.2 4.4 GO:0036376 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.2 5.7 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.2 4.6 GO:0005979 regulation of glycogen biosynthetic process(GO:0005979) regulation of glucan biosynthetic process(GO:0010962)
0.2 0.6 GO:0010633 negative regulation of epithelial cell migration(GO:0010633)
0.1 0.7 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.1 0.4 GO:0042766 nucleosome mobilization(GO:0042766)
0.1 1.3 GO:0043486 histone exchange(GO:0043486)
0.1 0.7 GO:0032264 IMP salvage(GO:0032264)
0.0 1.4 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.9 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.0 0.2 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.8 GO:0010669 epithelial structure maintenance(GO:0010669)
0.0 0.7 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 0.3 GO:0006301 postreplication repair(GO:0006301)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.4 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.3 4.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 8.5 GO:0043679 axon terminus(GO:0043679)
0.1 1.3 GO:0000812 Swr1 complex(GO:0000812)
0.1 1.4 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.1 0.4 GO:0016589 NURF complex(GO:0016589)
0.0 0.7 GO:0005861 troponin complex(GO:0005861)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.7 GO:1903136 cuprous ion binding(GO:1903136)
0.9 2.8 GO:0005499 vitamin D binding(GO:0005499)
0.3 4.6 GO:2001069 glycogen binding(GO:2001069)
0.3 1.5 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
0.2 4.4 GO:0001671 ATPase activator activity(GO:0001671)
0.1 5.1 GO:0017046 peptide hormone binding(GO:0017046)
0.1 1.9 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1 0.7 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.7 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 2.0 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.2 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 1.3 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.0 0.6 GO:0005112 Notch binding(GO:0005112)
0.0 0.9 GO:0046332 SMAD binding(GO:0046332)
0.0 0.4 GO:0035064 methylated histone binding(GO:0035064)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 5.1 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.1 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.6 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.9 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 1.4 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.9 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.2 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling