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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for pou2f3

Z-value: 0.95

Motif logo

Transcription factors associated with pou2f3

Gene Symbol Gene ID Gene Info
ENSDARG00000052387 POU class 2 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pou2f3dr11_v1_chr5_+_58550795_585507950.355.4e-04Click!

Activity profile of pou2f3 motif

Sorted Z-values of pou2f3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_46357080 12.13 ENSDART00000155571
ENSDART00000156541
wu:fb18f06
chr18_-_20869175 11.60 ENSDART00000090079
synemin, intermediate filament protein
chr13_+_22476742 10.83 ENSDART00000078759
ENSDART00000130101
ENSDART00000137220
ENSDART00000133065
ENSDART00000147348
LIM domain binding 3a
chr15_+_46356879 9.98 ENSDART00000154388
wu:fb18f06
chr20_+_572037 7.51 ENSDART00000028062
ENSDART00000152736
ENSDART00000031759
ENSDART00000162198
SET and MYND domain containing 2b
chr6_+_6924637 6.60 ENSDART00000065551
ENSDART00000151393
sterile alpha motif and leucine zipper containing kinase AZK
chr25_+_35019693 5.01 ENSDART00000046218
filamin C, gamma a (actin binding protein 280)
chr5_-_25583125 4.96 ENSDART00000031665
ENSDART00000145353
annexin A1a
chr10_+_26597990 4.95 ENSDART00000079187
four and a half LIM domains 1b
chr5_-_25582721 4.75 ENSDART00000123986
annexin A1a
chr24_+_35387517 4.51 ENSDART00000058571
snail family zinc finger 2
chr11_+_30647545 4.42 ENSDART00000114792
expressed sequence EH507706
chr3_+_39566999 4.42 ENSDART00000146867
aldolase a, fructose-bisphosphate, a
chr10_+_39084354 4.36 ENSDART00000158245
si:ch73-1a9.3
chr2_+_15048410 4.32 ENSDART00000058484
calponin 3, acidic b
chr22_+_5120033 4.32 ENSDART00000169200
muscle-specific beta 1 integrin binding protein
chr22_-_26595027 4.22 ENSDART00000184162

chr25_+_35189555 4.19 ENSDART00000044453
anoctamin 5a
chr4_+_7391110 4.14 ENSDART00000160708
ENSDART00000187823
troponin I4a
chr21_+_43328685 4.03 ENSDART00000109620
ENSDART00000139668
septin 8a
chr9_-_30165621 3.98 ENSDART00000089543
ABI family, member 3 (NESH) binding protein a
chr19_-_7450796 3.86 ENSDART00000104750
MLLT11, transcription factor 7 cofactor
chr9_-_34396264 3.83 ENSDART00000045754
growth hormone regulated TBC protein 1b
chr17_-_37395460 3.83 ENSDART00000148160
ENSDART00000075975
cysteine-rich protein 1
chr13_-_2189761 3.77 ENSDART00000166255
muscular LMNA-interacting protein
chr15_-_43284021 3.67 ENSDART00000041677
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr25_+_31227747 3.62 ENSDART00000033872
troponin I type 2a (skeletal, fast), tandem duplicate 1
chr3_-_50865079 3.51 ENSDART00000164295
peripheral myelin protein 22a
chr10_+_5268054 3.39 ENSDART00000114491
receptor tyrosine kinase-like orphan receptor 2
chr2_-_16159491 3.39 ENSDART00000110059
vav 3 guanine nucleotide exchange factor b
chr10_-_36793412 3.26 ENSDART00000185966
dehydrogenase/reductase (SDR family) member 13a, tandem duplicate 2
chr3_+_49021079 3.25 ENSDART00000162012
zgc:163083
chr25_+_3058924 3.20 ENSDART00000029580
ferritin, heavy polypeptide 1b
chr22_+_28446557 3.19 ENSDART00000089546
ABI family, member 3 (NESH) binding protein b
chr13_-_44423 3.16 ENSDART00000093247
general transcription factor IIA, 1-like
chr18_-_12327426 3.02 ENSDART00000136992
ENSDART00000114024
family with sequence similarity 107, member B
chr13_-_2215213 3.02 ENSDART00000129773
muscular LMNA-interacting protein
chr20_+_23625387 2.97 ENSDART00000147945
ENSDART00000150497
palladin, cytoskeletal associated protein
chr3_+_45687266 2.88 ENSDART00000131652
G protein-coupled receptor 146
chr19_-_25114701 2.86 ENSDART00000149035
protein tyrosine phosphatase type IVA, member 3
chr25_-_23526058 2.83 ENSDART00000191331
ENSDART00000062930
pleckstrin homology-like domain, family A, member 2
chr9_-_6380653 2.81 ENSDART00000078523
esophageal cancer related gene 4a
chr25_+_31277415 2.81 ENSDART00000036275
troponin I type 2a (skeletal, fast), tandem duplicate 4
chr20_+_40150612 2.80 ENSDART00000143680
ENSDART00000109681
ENSDART00000101041
ENSDART00000121818
triadin
chr14_+_48862987 2.73 ENSDART00000167810
zgc:154054
chr10_+_2582254 2.67 ENSDART00000016103
nucleoredoxin like 2
chr14_-_17622080 2.66 ENSDART00000112149
si:ch211-159i8.4
chr10_+_35439952 2.62 ENSDART00000006284
HERV-H LTR-associating 2a, tandem duplicate 2
chr2_-_16159203 2.53 ENSDART00000153480
vav 3 guanine nucleotide exchange factor b
chr8_+_22516728 2.48 ENSDART00000146013
si:ch211-261n11.3
chr5_+_27404946 2.47 ENSDART00000121886
ENSDART00000005025
hematopoietic death receptor
chr7_+_20017211 2.46 ENSDART00000100808
B-cell CLL/lymphoma 6, member B
chr17_+_38573471 2.45 ENSDART00000040627
spectrin, beta, erythrocytic
chr6_-_20875111 2.45 ENSDART00000115118
ENSDART00000159916
tensin 1a
chr10_+_9595575 2.44 ENSDART00000091780
ENSDART00000184287
ring finger and CCCH-type domains 2
chr8_-_39754621 2.42 ENSDART00000149243
si:ch211-170d8.8
chr19_-_5345930 2.38 ENSDART00000066620
ENSDART00000151398
keratin type 1 c19e
chr22_+_38049130 2.35 ENSDART00000097533
WW domain containing transcription regulator 1
chr23_+_11285662 2.34 ENSDART00000111028
cell adhesion molecule L1-like a
chr15_+_46344655 2.22 ENSDART00000155893
si:ch1073-340i21.2
chr2_+_36015049 2.21 ENSDART00000158276
laminin, gamma 2
chr18_-_15551360 2.20 ENSDART00000159915
ENSDART00000172690
PTPRF interacting protein, binding protein 1b (liprin beta 1)
chr2_+_32796873 2.19 ENSDART00000077511
chemokine (C-C motif) receptor 9a
chr19_-_22387141 2.18 ENSDART00000151234
epiplakin 1
chr4_+_4509996 2.15 ENSDART00000028694
glucosamine (N-acetyl)-6-sulfatase a
chr2_+_6243144 2.12 ENSDART00000058258
guanine nucleotide binding protein (G protein), gamma 5
chr2_+_20605186 2.11 ENSDART00000128505
olfactomedin-like 2Bb
chr9_+_3388099 2.10 ENSDART00000019910
distal-less homeobox 1a
chr14_+_3495542 2.07 ENSDART00000168934
glutathione S-transferase pi 2
chr23_-_33709964 2.07 ENSDART00000143333
ENSDART00000130338
POU class 6 homeobox 1
chr1_-_38815361 2.06 ENSDART00000148790
ENSDART00000148572
ENSDART00000149080
ankyrin repeat and SOCS box containing 5b
chr22_+_14051894 2.05 ENSDART00000142548
aldehyde oxidase 6
chr11_-_36341028 2.03 ENSDART00000146093
sortilin 1a
chr17_-_6451801 1.99 ENSDART00000064700
alpha-L-fucosidase 2
chr17_-_29213710 1.99 ENSDART00000076481
EH-domain containing 4
chr7_-_2116512 1.98 ENSDART00000098148
si:cabz01007802.1
chr23_+_22200467 1.97 ENSDART00000025414
solute carrier family 2 (facilitated glucose transporter), member 1a
chr7_-_18168493 1.95 ENSDART00000127428
pellino E3 ubiquitin protein ligase family member 3
chr2_+_20604775 1.95 ENSDART00000131501
olfactomedin-like 2Bb
chr17_-_25382367 1.94 ENSDART00000162306
ENSDART00000165282
LCK proto-oncogene, Src family tyrosine kinase
chr20_+_26967154 1.94 ENSDART00000153294
ENSDART00000132434
ENSDART00000143047
AHA1, activator of heat shock protein ATPase homolog 1a
chr7_+_38897836 1.93 ENSDART00000024330
cAMP responsive element binding protein 3-like 1
chr1_+_21563311 1.88 ENSDART00000147076
ENSDART00000006147
primase and polymerase (DNA-directed)
chr10_+_18911152 1.88 ENSDART00000030205
BCL2 interacting protein 3 like b
chr8_+_52479026 1.87 ENSDART00000162885
Danio rerio gamma-glutamyl hydrolase (LOC553228), mRNA.
chr20_-_45812144 1.87 ENSDART00000147897
ENSDART00000147637
fermitin family member 1
chr13_-_30645965 1.86 ENSDART00000109307
zinc finger, CCHC domain containing 24
chr19_-_25772980 1.84 ENSDART00000052393
par-6 family cell polarity regulator gamma b
chr8_+_36268747 1.80 ENSDART00000183154

chr15_-_31514818 1.80 ENSDART00000153978
high mobility group box 1b
chr23_+_33907899 1.79 ENSDART00000159445
citrate synthase
chr6_-_53048291 1.78 ENSDART00000103267
family with sequence similarity 212, member Ab
chr25_+_34915576 1.75 ENSDART00000073441
syntrophin, beta 2
chr14_+_15231097 1.74 ENSDART00000172430
si:dkey-203a12.3
chr21_+_34088377 1.73 ENSDART00000170070
myotubularin related protein 1b
chr3_-_5067585 1.73 ENSDART00000169609
thyrotrophic embryonic factor b
chr7_-_48667056 1.72 ENSDART00000006378
cyclin-dependent kinase inhibitor 1Ca
chr8_-_23573084 1.72 ENSDART00000139084
Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b
chr11_-_36341189 1.69 ENSDART00000159752
sortilin 1a
chr19_+_1688727 1.69 ENSDART00000115136
ENSDART00000166744
DENN/MADD domain containing 3a
chr6_-_54796072 1.68 ENSDART00000164445
troponin T type 2b (cardiac)
chr1_+_51496862 1.67 ENSDART00000150433
Meis homeobox 1 a
chr8_-_19977088 1.67 ENSDART00000139647
leupaxin
chr10_+_26667475 1.66 ENSDART00000133281
ENSDART00000147013
si:ch73-52f15.5
chr3_+_48473346 1.65 ENSDART00000166294
meteorin, glial cell differentiation regulator-like
chr19_-_47523793 1.64 ENSDART00000124234
gremlin 1a, DAN family BMP antagonist
chr3_-_39305291 1.64 ENSDART00000102674
phospholipase C, delta 3a
chr20_-_35750810 1.63 ENSDART00000153072
adhesion G protein-coupled receptor F8
chr2_-_3419890 1.62 ENSDART00000055618
IBA57, iron-sulfur cluster assembly
chr16_-_42523744 1.62 ENSDART00000017185
T-box 20
chr16_-_26140768 1.59 ENSDART00000143960
CD79a molecule, immunoglobulin-associated alpha
chr21_+_34088110 1.57 ENSDART00000145123
ENSDART00000029599
ENSDART00000147519
myotubularin related protein 1b
chr25_-_20666754 1.56 ENSDART00000158418
C-terminal Src kinase
chr19_-_340641 1.55 ENSDART00000183848
golgi phosphoprotein 3-like
chr10_-_22918214 1.54 ENSDART00000163908
ribonuclease, RNase K b
chr1_-_44161417 1.52 ENSDART00000083213
solute carrier family 43, member 3a
chr4_+_12292274 1.50 ENSDART00000061070
ENSDART00000150786
makorin, ring finger protein, 1
chr19_-_205104 1.50 ENSDART00000011890
zinc finger and BTB domain containing 22a
chr18_-_14677936 1.48 ENSDART00000111995
si:dkey-238o13.4
chr3_-_59981476 1.48 ENSDART00000035878
ENSDART00000124038
cerebellar degeneration-related protein 2-like
chr18_+_27318589 1.47 ENSDART00000037813
CD81 molecule b
chr2_-_23778180 1.46 ENSDART00000136782
si:dkey-24c2.7
chr9_-_8979468 1.45 ENSDART00000134646
inhibitor of growth family, member 1
chr6_+_36381709 1.45 ENSDART00000004727
Rh family, C glycoprotein, like 1
chr23_-_35066816 1.44 ENSDART00000168731
ENSDART00000163731

chr17_+_24109012 1.43 ENSDART00000156251
EH domain binding protein 1
chr10_-_31015535 1.43 ENSDART00000146116
pannexin 3
chr22_-_19552796 1.43 ENSDART00000148088
ENSDART00000105485
si:dkey-78l4.14
chr4_-_12388535 1.41 ENSDART00000017180
RERG/RAS-like a
chr17_-_50311009 1.41 ENSDART00000153653
si:ch73-50f9.4
chr12_+_17504559 1.41 ENSDART00000020628
cytohesin 3a
chr1_-_41287914 1.40 ENSDART00000022546
ENSDART00000126853
ENSDART00000125988
regulator of G protein signaling 12b
chr16_-_35952789 1.39 ENSDART00000180118
eva-1 homolog Ba (C. elegans)
chr9_-_1951144 1.37 ENSDART00000082355
homeobox D4a
chr1_-_51038885 1.36 ENSDART00000035150
spastin
chr25_+_34915762 1.36 ENSDART00000191776
syntrophin, beta 2
chr5_-_23909934 1.35 ENSDART00000142516
si:ch211-135f11.1
chr12_-_48188928 1.34 ENSDART00000184384
phosphatase domain containing, paladin 1a
chr5_-_32274383 1.34 ENSDART00000122889
myosin, heavy polypeptide 1.3, skeletal muscle
chr11_+_37275448 1.33 ENSDART00000161423
cysteine-rich with EGF-like domains 1a
chr3_-_45361573 1.33 ENSDART00000154796
interleukin 21 receptor, tandem duplicate 1
chr5_+_51848756 1.32 ENSDART00000087467
ENSDART00000184466
cardiomyopathy associated 5
chr2_+_55365727 1.32 ENSDART00000162943

chr7_-_44704910 1.31 ENSDART00000037850
dynein, cytoplasmic 1, light intermediate chain 2
chr20_+_29691118 1.30 ENSDART00000164121
membrane bound O-acyltransferase domain containing 2b
chr18_+_30567945 1.28 ENSDART00000078894
interferon regulatory factor 8
chr1_-_51720633 1.25 ENSDART00000045894
ribonuclease H2, subunit A
chr2_-_48171112 1.23 ENSDART00000156258
phosphofructokinase, platelet b
chr6_-_30932078 1.22 ENSDART00000028612
phosphodiesterase 4B, cAMP-specific a
chr11_+_1608348 1.22 ENSDART00000162438
si:dkey-40c23.3
chr6_-_35032792 1.22 ENSDART00000168256
discoidin domain receptor tyrosine kinase 2a
chr11_+_10984293 1.21 ENSDART00000065933
integrin, beta 6
chr5_-_24127310 1.20 ENSDART00000182700
ENSDART00000154313
capping protein (actin filament), gelsolin-like a
chr23_-_33775145 1.18 ENSDART00000132147
ENSDART00000027959
ENSDART00000160116
Rac GTPase activating protein 1
chr7_+_30725473 1.18 ENSDART00000085716
myotubularin related protein 10
chr10_+_13000370 1.18 ENSDART00000180545
lysophosphatidic acid receptor 1
chr10_+_39893439 1.17 ENSDART00000003435
small fragment nuclease
chr1_-_46989650 1.17 ENSDART00000129072
ENSDART00000150507
si:dkey-22n8.3
chr24_-_28333029 1.16 ENSDART00000149015
ENSDART00000129174
protein kinase, AMP-activated, gamma 2 non-catalytic subunit a
chr10_+_26871751 1.16 ENSDART00000089205
EH domain binding protein 1-like 1b
chr25_-_18140305 1.16 ENSDART00000180222
kit ligand a
chr19_+_43579786 1.15 ENSDART00000138404
si:ch211-199g17.2
chr11_-_43200994 1.14 ENSDART00000164700
spectrin, beta, non-erythrocytic 1
chr22_+_9091913 1.13 ENSDART00000186598

chr20_-_31497300 1.13 ENSDART00000046841
SAM and SH3 domain containing 1a
chr1_+_51039558 1.13 ENSDART00000024743
dpy-30 histone methyltransferase complex regulatory subunit
chr9_+_21281652 1.11 ENSDART00000113352
large tumor suppressor kinase 2
chr7_+_38898208 1.10 ENSDART00000172251
cAMP responsive element binding protein 3-like 1
chr4_-_67980261 1.09 ENSDART00000182305
si:ch211-223k15.1
chr5_-_54481692 1.08 ENSDART00000165719
F-box and WD repeat domain containing 5
chr19_-_30811161 1.08 ENSDART00000103524
MYCL proto-oncogene, bHLH transcription factor b
chr13_-_34781984 1.07 ENSDART00000172138
isthmin 1
chr12_-_11593436 1.06 ENSDART00000138954
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1b
chr11_-_42918971 1.06 ENSDART00000052912
protocadherin 20
chr8_+_49433663 1.06 ENSDART00000140481
ENSDART00000180714
NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)
chr18_-_21950751 1.05 ENSDART00000043452
translin-associated factor X interacting protein 1
chr4_+_25950372 1.04 ENSDART00000125767
methionyl aminopeptidase 2a
chr19_-_5103313 1.03 ENSDART00000037007
triosephosphate isomerase 1a
chr14_-_17588345 1.02 ENSDART00000143486
selenoprotein T, 2
chr24_-_25428176 1.02 ENSDART00000090010
phosphate regulating endopeptidase homolog, X-linked
chr1_+_1896737 1.02 ENSDART00000152442
si:ch211-132g1.6
chr20_-_54198130 1.01 ENSDART00000160409
ADP-ribosylation factor 6a
chr20_-_46817223 1.01 ENSDART00000100336
estrogen-related receptor gamma b
chr3_+_14543953 1.01 ENSDART00000161710
erythropoietin receptor
chr12_+_2677303 1.01 ENSDART00000093113
anthrax toxin receptor 1c
chr18_+_2222447 1.00 ENSDART00000185927
PIGB opposite strand 1
chr21_-_37733287 0.99 ENSDART00000157826
membrane protein, palmitoylated 1
chr6_-_24053404 0.99 ENSDART00000168511
si:dkey-44g17.6
chr16_-_38333976 0.98 ENSDART00000031895
CDC42 small effector 1
chr25_+_32496723 0.98 ENSDART00000087978
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2a
chr12_-_10409961 0.96 ENSDART00000149521
ENSDART00000052001
eukaryotic elongation factor 2 kinase
chr7_-_58098814 0.96 ENSDART00000147287
ENSDART00000043984
ankyrin 2b, neuronal
chr14_-_33894915 0.95 ENSDART00000143290
urotensin-related peptide 1
chr25_+_19238175 0.94 ENSDART00000110730
ENSDART00000193619
ENSDART00000154420
diphosphoinositol pentakisphosphate kinase 1b
chr25_-_20666328 0.94 ENSDART00000098076
C-terminal Src kinase
chr17_+_4400738 0.94 ENSDART00000170204
si:zfos-364h11.1
chr25_+_16601839 0.93 ENSDART00000008986
ATPase H+ transporting V1 subunit E1a
chr15_-_23482088 0.93 ENSDART00000185823
ENSDART00000185523
NLR family member X1
chr17_-_30975978 0.93 ENSDART00000051697
Enah/Vasp-like a
chr21_-_25295087 0.92 ENSDART00000087910
ENSDART00000147860
suppression of tumorigenicity 14 (colon carcinoma) b

Network of associatons between targets according to the STRING database.

First level regulatory network of pou2f3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 9.7 GO:0042088 neutrophil apoptotic process(GO:0001781) regulation of T-helper 1 type immune response(GO:0002825) positive regulation of T-helper 1 type immune response(GO:0002827) negative regulation of type 2 immune response(GO:0002829) inflammatory cell apoptotic process(GO:0006925) regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of phospholipase A2 activity(GO:0032429) interleukin-2 production(GO:0032623) regulation of interleukin-2 production(GO:0032663) positive regulation of interleukin-2 production(GO:0032743) myeloid cell apoptotic process(GO:0033028) regulation of neutrophil apoptotic process(GO:0033029) positive regulation of neutrophil apoptotic process(GO:0033031) regulation of myeloid cell apoptotic process(GO:0033032) positive regulation of myeloid cell apoptotic process(GO:0033034) T-helper 1 type immune response(GO:0042088) positive regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043372) T-helper 1 cell differentiation(GO:0045063) positive regulation of T-helper cell differentiation(GO:0045624) regulation of T-helper 1 cell differentiation(GO:0045625) positive regulation of T-helper 1 cell differentiation(GO:0045627) regulation of T-helper 2 cell differentiation(GO:0045628) negative regulation of T-helper 2 cell differentiation(GO:0045629) positive regulation of fatty acid biosynthetic process(GO:0045723) positive regulation of alpha-beta T cell differentiation(GO:0046638) neutrophil clearance(GO:0097350) negative regulation of phospholipase A2 activity(GO:1900138) positive regulation of CD4-positive, alpha-beta T cell activation(GO:2000516) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
1.3 3.8 GO:0071236 cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237)
0.9 7.5 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.9 2.8 GO:0070314 G1 to G0 transition(GO:0070314)
0.8 3.9 GO:0090200 regulation of mitochondrial membrane potential(GO:0051881) regulation of release of cytochrome c from mitochondria(GO:0090199) positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.6 1.9 GO:0043504 mitochondrial DNA repair(GO:0043504)
0.6 2.5 GO:0036462 TRAIL-activated apoptotic signaling pathway(GO:0036462)
0.6 5.0 GO:0046716 muscle cell cellular homeostasis(GO:0046716)
0.5 2.5 GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060368)
0.5 2.4 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.5 3.7 GO:0006895 Golgi to endosome transport(GO:0006895)
0.5 3.2 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.5 1.4 GO:0051230 protein hexamerization(GO:0034214) mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230)
0.4 1.3 GO:0045649 regulation of macrophage differentiation(GO:0045649)
0.4 1.6 GO:0055021 regulation of cardiac muscle tissue growth(GO:0055021) regulation of cardiac muscle cell proliferation(GO:0060043)
0.4 2.0 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
0.4 1.5 GO:0019242 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.4 1.9 GO:1903523 negative regulation of heart contraction(GO:0045822) negative regulation of blood circulation(GO:1903523)
0.4 2.1 GO:0035881 amacrine cell differentiation(GO:0035881)
0.3 1.6 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
0.3 2.2 GO:0045109 intermediate filament organization(GO:0045109) intermediate filament bundle assembly(GO:0045110)
0.3 0.9 GO:0006089 lactate metabolic process(GO:0006089)
0.3 2.0 GO:0016137 glycoside metabolic process(GO:0016137) glycoside catabolic process(GO:0016139)
0.3 2.0 GO:0046323 glucose import(GO:0046323)
0.3 1.9 GO:0032732 positive regulation of interleukin-1 production(GO:0032732)
0.3 1.3 GO:0009794 regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.3 1.0 GO:0070084 protein initiator methionine removal(GO:0070084)
0.3 1.6 GO:0048194 Golgi vesicle budding(GO:0048194)
0.2 1.7 GO:1904030 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.2 2.6 GO:0031294 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.2 5.7 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.2 0.7 GO:2000405 response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869) negative regulation of lymphocyte migration(GO:2000402) negative regulation of T cell migration(GO:2000405)
0.2 2.2 GO:0097534 lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535)
0.2 0.6 GO:1900364 negative regulation of mRNA 3'-end processing(GO:0031441) negative regulation of mRNA polyadenylation(GO:1900364)
0.2 1.2 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.2 10.6 GO:0003009 skeletal muscle contraction(GO:0003009)
0.2 5.3 GO:0031100 organ regeneration(GO:0031100)
0.2 0.8 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.2 1.0 GO:0036371 protein localization to T-tubule(GO:0036371)
0.2 2.1 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.2 0.4 GO:0061588 calcium activated phospholipid scrambling(GO:0061588)
0.2 3.5 GO:0042574 retinal metabolic process(GO:0042574)
0.2 1.4 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.2 1.9 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.2 0.5 GO:0009162 deoxyribonucleoside monophosphate metabolic process(GO:0009162)
0.2 0.7 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.2 0.9 GO:0023041 neuronal signal transduction(GO:0023041)
0.2 2.1 GO:0048696 collateral sprouting in absence of injury(GO:0048669) regulation of collateral sprouting in absence of injury(GO:0048696)
0.2 2.3 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.2 1.1 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1 1.0 GO:0036010 protein localization to endosome(GO:0036010)
0.1 1.0 GO:0032475 otolith formation(GO:0032475)
0.1 2.1 GO:0043248 proteasome assembly(GO:0043248)
0.1 3.6 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068)
0.1 0.4 GO:0032816 regulation of natural killer cell activation(GO:0032814) positive regulation of natural killer cell activation(GO:0032816) TRIF-dependent toll-like receptor signaling pathway(GO:0035666)
0.1 1.2 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
0.1 0.3 GO:0050879 multicellular organismal movement(GO:0050879) musculoskeletal movement(GO:0050881)
0.1 1.1 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.1 1.7 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 1.0 GO:1901998 toxin transport(GO:1901998)
0.1 0.7 GO:0038065 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.1 1.6 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 0.3 GO:0048682 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.1 1.3 GO:0006020 inositol metabolic process(GO:0006020)
0.1 1.8 GO:0014823 response to activity(GO:0014823)
0.1 0.8 GO:0071539 protein localization to centrosome(GO:0071539)
0.1 0.4 GO:0036306 embryonic heart tube elongation(GO:0036306)
0.1 0.5 GO:0071800 podosome assembly(GO:0071800)
0.1 2.7 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.1 4.5 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 0.6 GO:0046620 regulation of organ growth(GO:0046620)
0.1 0.5 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.1 4.8 GO:0051693 actin filament capping(GO:0051693)
0.1 0.5 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.1 1.0 GO:0061300 cerebellum vasculature development(GO:0061300)
0.1 0.5 GO:2000463 postsynaptic density assembly(GO:0097107) modulation of excitatory postsynaptic potential(GO:0098815) positive regulation of excitatory postsynaptic potential(GO:2000463)
0.1 3.5 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.1 0.9 GO:0051122 lipoxygenase pathway(GO:0019372) linoleic acid metabolic process(GO:0043651) hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.1 1.6 GO:0030183 B cell differentiation(GO:0030183)
0.1 0.4 GO:0060055 larval development(GO:0002164) larval heart development(GO:0007508) angiogenesis involved in wound healing(GO:0060055)
0.1 0.7 GO:0030431 sleep(GO:0030431)
0.1 2.9 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.1 0.2 GO:0046833 regulation of nucleobase-containing compound transport(GO:0032239) positive regulation of nucleobase-containing compound transport(GO:0032241) positive regulation of nucleocytoplasmic transport(GO:0046824) regulation of RNA export from nucleus(GO:0046831) positive regulation of RNA export from nucleus(GO:0046833) messenger ribonucleoprotein complex assembly(GO:1990120)
0.1 6.9 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.1 9.2 GO:0007626 locomotory behavior(GO:0007626)
0.1 1.7 GO:0051289 protein homotetramerization(GO:0051289)
0.1 1.2 GO:0006198 cAMP catabolic process(GO:0006198)
0.1 3.8 GO:0007528 neuromuscular junction development(GO:0007528)
0.1 1.7 GO:0060048 cardiac muscle contraction(GO:0060048)
0.1 1.1 GO:0010824 regulation of centrosome duplication(GO:0010824)
0.1 1.4 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.1 0.6 GO:0019883 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.1 0.6 GO:0034122 negative regulation of toll-like receptor signaling pathway(GO:0034122)
0.1 0.3 GO:0048662 regulation of smooth muscle cell proliferation(GO:0048660) negative regulation of smooth muscle cell proliferation(GO:0048662)
0.1 0.2 GO:0035095 behavioral response to nicotine(GO:0035095)
0.1 0.3 GO:0042766 nucleosome mobilization(GO:0042766)
0.1 0.5 GO:0032228 regulation of synaptic transmission, GABAergic(GO:0032228)
0.1 4.2 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 0.3 GO:0030242 pexophagy(GO:0030242)
0.0 0.7 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.5 GO:0030216 keratinocyte differentiation(GO:0030216)
0.0 2.1 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 1.1 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 2.0 GO:0032456 endocytic recycling(GO:0032456)
0.0 1.2 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.4 GO:0072498 embryonic skeletal joint development(GO:0072498)
0.0 1.0 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0 0.4 GO:0035094 response to nicotine(GO:0035094)
0.0 0.3 GO:0006111 regulation of gluconeogenesis(GO:0006111)
0.0 2.4 GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:0000288)
0.0 3.7 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.7 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 1.2 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.0 0.1 GO:0035046 pronuclear migration(GO:0035046)
0.0 0.2 GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence(GO:0045050)
0.0 1.9 GO:0030217 T cell differentiation(GO:0030217)
0.0 3.6 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.4 GO:0051877 pigment granule aggregation in cell center(GO:0051877)
0.0 0.2 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.0 0.1 GO:0035553 oxidative single-stranded RNA demethylation(GO:0035553)
0.0 1.5 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.0 0.2 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.0 0.3 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.3 GO:0039023 pronephric duct morphogenesis(GO:0039023)
0.0 4.0 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 1.3 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.0 0.5 GO:0021654 rhombomere boundary formation(GO:0021654)
0.0 0.9 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 3.1 GO:0043068 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.0 0.6 GO:0015701 bicarbonate transport(GO:0015701)
0.0 5.2 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 0.2 GO:0098787 mRNA cleavage involved in mRNA processing(GO:0098787) pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0 0.4 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 2.1 GO:0001702 gastrulation with mouth forming second(GO:0001702)
0.0 1.7 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 2.5 GO:0001817 regulation of cytokine production(GO:0001817)
0.0 0.5 GO:0021884 forebrain neuron development(GO:0021884)
0.0 1.9 GO:0008285 negative regulation of cell proliferation(GO:0008285)
0.0 0.7 GO:0006306 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 2.2 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.0 0.3 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.2 GO:0031061 negative regulation of histone methylation(GO:0031061)
0.0 0.6 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.0 0.7 GO:0030199 collagen fibril organization(GO:0030199)
0.0 1.7 GO:0009880 embryonic pattern specification(GO:0009880)
0.0 0.2 GO:0006566 threonine metabolic process(GO:0006566) threonine catabolic process(GO:0006567)
0.0 0.2 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.3 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 0.1 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.2 GO:0022401 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) G-protein coupled receptor internalization(GO:0002031) negative adaptation of signaling pathway(GO:0022401) adaptation of signaling pathway(GO:0023058)
0.0 1.4 GO:0090305 nucleic acid phosphodiester bond hydrolysis(GO:0090305)
0.0 0.2 GO:0019934 cGMP-mediated signaling(GO:0019934)
0.0 0.3 GO:0048570 notochord morphogenesis(GO:0048570)
0.0 0.3 GO:0071350 interleukin-15-mediated signaling pathway(GO:0035723) response to interleukin-15(GO:0070672) cellular response to interleukin-15(GO:0071350)
0.0 0.8 GO:0001570 vasculogenesis(GO:0001570)
0.0 1.4 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 0.3 GO:0046473 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0 0.7 GO:0030282 bone mineralization(GO:0030282)
0.0 0.1 GO:0018063 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.0 0.8 GO:0030318 melanocyte differentiation(GO:0030318)
0.0 1.0 GO:0008217 regulation of blood pressure(GO:0008217)
0.0 0.1 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.0 0.3 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.2 GO:0060729 maintenance of gastrointestinal epithelium(GO:0030277) intestinal epithelial structure maintenance(GO:0060729)
0.0 0.4 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 0.7 GO:0031076 embryonic camera-type eye development(GO:0031076)
0.0 0.3 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.0 GO:1902804 negative regulation of neurotransmitter secretion(GO:0046929) response to cAMP(GO:0051591) cellular response to cAMP(GO:0071320) negative regulation of synaptic vesicle transport(GO:1902804) negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 1.1 GO:0016485 protein processing(GO:0016485)
0.0 0.2 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.1 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.2 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.7 3.6 GO:0008091 spectrin(GO:0008091)
0.6 9.7 GO:0016328 lateral plasma membrane(GO:0016328)
0.4 1.2 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.4 1.6 GO:0019815 B cell receptor complex(GO:0019815)
0.3 1.2 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.3 14.2 GO:0031941 filamentous actin(GO:0031941)
0.3 12.2 GO:0005861 troponin complex(GO:0005861)
0.2 2.2 GO:0045095 keratin filament(GO:0045095)
0.2 3.1 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.2 0.7 GO:0060171 stereocilium membrane(GO:0060171)
0.2 6.8 GO:0016605 PML body(GO:0016605)
0.1 13.8 GO:0005882 intermediate filament(GO:0005882)
0.1 5.5 GO:0031105 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.1 3.1 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 3.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 2.8 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 0.7 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 1.2 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.1 0.7 GO:0098651 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.1 0.6 GO:0070062 extracellular exosome(GO:0070062)
0.1 1.4 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.1 1.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 1.9 GO:0005921 gap junction(GO:0005921)
0.1 2.9 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 1.3 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 4.6 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 0.3 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 1.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 2.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 0.2 GO:0042382 paraspeckles(GO:0042382)
0.1 0.6 GO:0000974 Prp19 complex(GO:0000974)
0.1 0.3 GO:0031415 NatA complex(GO:0031415)
0.1 0.4 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 1.1 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.1 0.7 GO:0031010 ISWI-type complex(GO:0031010)
0.1 1.0 GO:0030315 T-tubule(GO:0030315)
0.1 3.0 GO:0005657 replication fork(GO:0005657)
0.1 0.6 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.4 GO:0034464 BBSome(GO:0034464)
0.0 0.8 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.7 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306)
0.0 1.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.5 GO:0002102 podosome(GO:0002102)
0.0 0.2 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.9 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.8 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.4 GO:0030496 midbody(GO:0030496)
0.0 0.9 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.0 0.2 GO:0070209 ASTRA complex(GO:0070209)
0.0 0.2 GO:0070319 Golgi to plasma membrane transport vesicle(GO:0070319)
0.0 1.5 GO:0005795 Golgi stack(GO:0005795)
0.0 0.6 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.2 GO:0018444 translation release factor complex(GO:0018444)
0.0 2.9 GO:0030027 lamellipodium(GO:0030027)
0.0 2.1 GO:0005884 actin filament(GO:0005884)
0.0 0.7 GO:0045180 basal cortex(GO:0045180)
0.0 3.5 GO:0005925 focal adhesion(GO:0005925)
0.0 0.1 GO:0044611 nuclear pore inner ring(GO:0044611)
0.0 0.3 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.9 GO:0043204 perikaryon(GO:0043204)
0.0 0.5 GO:0098844 dendritic spine head(GO:0044327) postsynaptic endocytic zone membrane(GO:0098844)
0.0 0.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 3.9 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 2.2 GO:0016324 apical plasma membrane(GO:0016324)
0.0 2.0 GO:0005581 collagen trimer(GO:0005581)
0.0 0.9 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.9 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 8.7 GO:0009986 cell surface(GO:0009986)
0.0 0.2 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.6 GO:0030125 clathrin vesicle coat(GO:0030125)
0.0 0.5 GO:0008278 cohesin complex(GO:0008278)
0.0 1.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.2 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.3 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 4.8 GO:0000785 chromatin(GO:0000785)
0.0 0.8 GO:0000779 condensed chromosome, centromeric region(GO:0000779)
0.0 0.2 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 1.1 GO:0000922 spindle pole(GO:0000922)
0.0 0.0 GO:1990879 CST complex(GO:1990879)
0.0 0.2 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.2 GO:0031312 extrinsic component of organelle membrane(GO:0031312)
0.0 3.7 GO:0005815 microtubule organizing center(GO:0005815)
0.0 0.1 GO:0035101 FACT complex(GO:0035101)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.3 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.1 GO:0031931 TORC1 complex(GO:0031931)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 6.8 GO:0005521 lamin binding(GO:0005521)
1.6 9.7 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.7 2.1 GO:0016623 aldehyde oxidase activity(GO:0004031) oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.7 2.0 GO:0004560 alpha-L-fucosidase activity(GO:0004560) fucosidase activity(GO:0015928)
0.6 4.3 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262)
0.6 4.4 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.5 10.8 GO:0051393 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.5 7.5 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.4 1.5 GO:0004807 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
0.4 2.2 GO:0019215 intermediate filament binding(GO:0019215)
0.3 2.4 GO:0035613 RNA stem-loop binding(GO:0035613)
0.3 1.4 GO:0048487 beta-tubulin binding(GO:0048487)
0.3 3.3 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.3 3.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.3 1.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.3 3.2 GO:0008199 ferric iron binding(GO:0008199)
0.2 0.9 GO:0033857 inositol heptakisphosphate kinase activity(GO:0000829) diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.2 5.0 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 1.7 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.2 0.6 GO:0016920 pyroglutamyl-peptidase activity(GO:0016920)
0.2 1.6 GO:0036122 BMP binding(GO:0036122)
0.2 1.2 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.2 0.9 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.2 0.7 GO:0071889 14-3-3 protein binding(GO:0071889)
0.2 1.7 GO:0005522 profilin binding(GO:0005522)
0.2 3.0 GO:0035497 cAMP response element binding(GO:0035497)
0.2 1.6 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.2 1.7 GO:0031013 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.1 2.1 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 3.1 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 0.9 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 1.2 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.1 0.4 GO:0052834 inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.1 1.9 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 2.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.9 GO:0004051 arachidonate 5-lipoxygenase activity(GO:0004051)
0.1 0.9 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.1 2.0 GO:0005355 glucose transmembrane transporter activity(GO:0005355) monosaccharide transmembrane transporter activity(GO:0015145) hexose transmembrane transporter activity(GO:0015149)
0.1 1.8 GO:0005080 protein kinase C binding(GO:0005080)
0.1 1.2 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.1 0.3 GO:0036310 annealing helicase activity(GO:0036310)
0.1 2.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 0.9 GO:0004457 lactate dehydrogenase activity(GO:0004457)
0.1 0.6 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 0.4 GO:0061656 SUMO conjugating enzyme activity(GO:0061656)
0.1 2.8 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 4.6 GO:0044325 ion channel binding(GO:0044325)
0.1 1.4 GO:0008301 DNA binding, bending(GO:0008301)
0.1 0.8 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 1.9 GO:0022829 wide pore channel activity(GO:0022829)
0.1 0.5 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.1 1.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.1 2.7 GO:0035064 methylated histone binding(GO:0035064)
0.1 2.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 1.3 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 2.7 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 1.2 GO:0016208 AMP binding(GO:0016208)
0.1 0.8 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 0.8 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 0.3 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189)
0.1 1.2 GO:0052744 phosphatidylinositol-3-phosphatase activity(GO:0004438) phosphatidylinositol monophosphate phosphatase activity(GO:0052744)
0.1 0.9 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.1 3.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 2.1 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 0.5 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175) superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 4.8 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 2.1 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.1 1.4 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.1 0.9 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 0.7 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 1.0 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 3.6 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 0.2 GO:0043560 insulin-activated receptor activity(GO:0005009) insulin receptor substrate binding(GO:0043560)
0.0 4.2 GO:0005254 chloride channel activity(GO:0005254)
0.0 4.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.8 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.8 GO:0016251 obsolete general RNA polymerase II transcription factor activity(GO:0016251)
0.0 1.2 GO:0051020 GTPase binding(GO:0051020)
0.0 0.8 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.0 1.2 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.1 GO:1990931 RNA N6-methyladenosine dioxygenase activity(GO:1990931)
0.0 0.6 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 3.0 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.2 GO:0008743 L-threonine 3-dehydrogenase activity(GO:0008743)
0.0 4.6 GO:0060090 binding, bridging(GO:0060090)
0.0 3.3 GO:1901981 phosphatidylinositol phosphate binding(GO:1901981)
0.0 0.4 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.3 GO:0003834 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.0 1.4 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.3 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.0 0.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.3 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 0.3 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.1 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.2 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.0 1.0 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 0.2 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.7 GO:0008013 beta-catenin binding(GO:0008013)
0.0 2.9 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.2 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.4 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.1 GO:0004408 holocytochrome-c synthase activity(GO:0004408)
0.0 0.3 GO:0042171 lysophosphatidic acid acyltransferase activity(GO:0042171)
0.0 0.1 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.8 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 5.0 GO:0005096 GTPase activator activity(GO:0005096)
0.0 2.2 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 3.7 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 1.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.3 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 6.9 GO:0003779 actin binding(GO:0003779)
0.0 0.2 GO:0070411 I-SMAD binding(GO:0070411)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 7.6 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.2 2.2 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 3.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 2.2 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.1 5.6 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 1.2 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 2.9 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 1.3 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.1 2.5 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.1 1.6 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 1.6 PID BCR 5PATHWAY BCR signaling pathway
0.1 0.8 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 1.1 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 2.1 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 1.4 PID AURORA B PATHWAY Aurora B signaling
0.0 1.9 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.3 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.3 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 1.1 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.3 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 0.4 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.6 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 1.1 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.3 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.5 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.4 PID MYC PATHWAY C-MYC pathway
0.0 0.7 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.1 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 1.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.4 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.6 PID AR PATHWAY Coregulation of Androgen receptor activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.4 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.3 3.2 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.2 3.6 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 3.0 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 0.4 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 2.4 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.1 0.5 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 1.0 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 1.8 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 2.4 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 1.4 REACTOME KINESINS Genes involved in Kinesins
0.1 0.8 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.1 0.6 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.1 0.6 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.9 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 1.4 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.4 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 1.6 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 2.2 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 0.4 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.8 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.9 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.4 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 1.1 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.3 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.5 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 1.3 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 1.5 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.7 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.9 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.9 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 0.3 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.9 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.2 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.3 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.5 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.2 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.0 0.2 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.3 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor