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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for pou4f2

Z-value: 1.47

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Transcription factors associated with pou4f2

Gene Symbol Gene ID Gene Info
pou4f2
ENSDARG00000069737 POU class 4 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pou4f2dr11_v1_chr1_+_36436936_364369360.912.2e-37Click!

Activity profile of pou4f2 motif

Sorted Z-values of pou4f2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_15433671 35.56 ENSDART00000149568
fabp7a
fatty acid binding protein 7, brain, a
chr17_+_15433518 34.77 ENSDART00000026180
fabp7a
fatty acid binding protein 7, brain, a
chr2_-_21082695 30.84 ENSDART00000032502
nebl
nebulette
chr6_+_27146671 25.38 ENSDART00000156792
kif1aa
kinesin family member 1Aa
chr7_+_73630751 23.58 ENSDART00000159745
PCP4L1
si:dkey-46i9.1
chr18_-_1185772 23.05 ENSDART00000143245
nptnb
neuroplastin b
chr24_-_21923930 22.86 ENSDART00000131944
tagln3b
transgelin 3b
chr9_-_32753535 22.83 ENSDART00000060006
olig2
oligodendrocyte lineage transcription factor 2
chr25_-_13842618 21.31 ENSDART00000160258
mapk8ip1a
mitogen-activated protein kinase 8 interacting protein 1a
chr8_+_16025554 21.01 ENSDART00000110171
elavl4
ELAV like neuron-specific RNA binding protein 4
chr16_-_12173554 20.84 ENSDART00000110567
ENSDART00000155935
clstn3
calsyntenin 3
chr5_+_37966505 20.19 ENSDART00000127648
pafah1b2
platelet-activating factor acetylhydrolase 1b, catalytic subunit 2
chr4_-_1360495 19.48 ENSDART00000164623
ptn
pleiotrophin
chr19_-_32641725 19.25 ENSDART00000165006
ENSDART00000188185
hpca
hippocalcin
chr19_-_5103313 17.56 ENSDART00000037007
tpi1a
triosephosphate isomerase 1a
chr7_+_25059845 17.02 ENSDART00000077215
ppp2r5b
protein phosphatase 2, regulatory subunit B', beta
chr12_-_35787801 16.27 ENSDART00000171682
aatkb
apoptosis-associated tyrosine kinase b
chr1_-_50859053 15.75 ENSDART00000132779
ENSDART00000137648
si:dkeyp-123h10.2
si:dkeyp-123h10.2
chr2_-_30784198 15.71 ENSDART00000182523
ENSDART00000147355
rgs20
regulator of G protein signaling 20
chr19_-_31402429 15.47 ENSDART00000137292
tmem106bb
transmembrane protein 106Bb
chr11_-_37509001 14.60 ENSDART00000109753
bsnb
bassoon (presynaptic cytomatrix protein) b
chr14_-_31465905 13.86 ENSDART00000173108
gpc3
glypican 3
chr16_-_26074529 13.45 ENSDART00000148653
ENSDART00000148923
tmem145
transmembrane protein 145
chr16_+_29303971 13.07 ENSDART00000087149
hapln2
hyaluronan and proteoglycan link protein 2
chr17_+_8183393 12.90 ENSDART00000155957
tulp4b
tubby like protein 4b
chr20_-_18736281 12.84 ENSDART00000142837
enpp5
ectonucleotide pyrophosphatase/phosphodiesterase 5
chr19_-_5103141 12.65 ENSDART00000150952
tpi1a
triosephosphate isomerase 1a
chr6_+_54187643 11.92 ENSDART00000056830
pacsin1b
protein kinase C and casein kinase substrate in neurons 1b
chr18_-_40509006 11.71 ENSDART00000021372
chrna5
cholinergic receptor, nicotinic, alpha 5
chr13_+_36622100 11.59 ENSDART00000133198
si:ch211-67f24.7
si:ch211-67f24.7
chr18_+_783936 11.28 ENSDART00000193357
rpp25b
ribonuclease P and MRP subunit p25, b
chr2_+_50608099 10.83 ENSDART00000185805
ENSDART00000111135
neurod6b
neuronal differentiation 6b
chr20_+_41756996 10.69 ENSDART00000186393
fam184a
family with sequence similarity 184, member A
chr21_+_28958471 10.53 ENSDART00000144331
ENSDART00000005929
ppp3ca
protein phosphatase 3, catalytic subunit, alpha isozyme
chr7_+_25915089 10.52 ENSDART00000173648
hmgb3a
high mobility group box 3a
chr3_+_33341640 10.43 ENSDART00000186352
pyya
peptide YYa
chr23_-_28141419 10.28 ENSDART00000133039
tac3a
tachykinin 3a
chr16_-_12173399 9.99 ENSDART00000142574
clstn3
calsyntenin 3
chr1_+_25801648 9.99 ENSDART00000129471
gucy1b1
guanylate cyclase 1 soluble subunit beta 1
chr7_+_19552381 9.95 ENSDART00000169060
si:ch211-212k18.5
si:ch211-212k18.5
chr18_-_2433011 9.85 ENSDART00000181922
ENSDART00000193276
CR769778.1

chr15_+_14826966 9.66 ENSDART00000157912
ENSDART00000171133
or130-1
odorant receptor, family H, subfamily 130, member 1
chr13_-_14487524 9.45 ENSDART00000141103
gfra4a
GDNF family receptor alpha 4a
chr1_-_53756851 9.06 ENSDART00000122445
akt3b
v-akt murine thymoma viral oncogene homolog 3b
chr13_+_1089942 9.00 ENSDART00000054322
cnrip1b
cannabinoid receptor interacting protein 1b
chr1_-_22512063 8.66 ENSDART00000031546
ENSDART00000190987
chrna6
cholinergic receptor, nicotinic, alpha 6
chr4_-_23908802 8.65 ENSDART00000138873
celf2
cugbp, Elav-like family member 2
chr3_-_30434016 8.49 ENSDART00000150958
lrrc4ba
leucine rich repeat containing 4Ba
chr14_+_45883687 8.46 ENSDART00000114790
flrt1b
fibronectin leucine rich transmembrane protein 1b
chr12_+_24952902 8.33 ENSDART00000189086
ENSDART00000014868
calm3a
calmodulin 3a (phosphorylase kinase, delta)
chr5_+_51443009 7.88 ENSDART00000083350
rasgrf2b
Ras protein-specific guanine nucleotide-releasing factor 2b
chr9_+_21793565 7.75 ENSDART00000134915
rev1
REV1, polymerase (DNA directed)
chr2_+_29249204 7.60 ENSDART00000168957
cdh18a
cadherin 18, type 2a
chr21_-_25612658 7.48 ENSDART00000115276
fibpb
fibroblast growth factor (acidic) intracellular binding protein b
chr4_-_1801519 7.40 ENSDART00000188604
ENSDART00000135749
nudt4b
nudix (nucleoside diphosphate linked moiety X)-type motif 4b
chr15_-_16121496 7.31 ENSDART00000128624
sgk494a
uncharacterized serine/threonine-protein kinase SgK494a
chr17_+_11675362 7.05 ENSDART00000157911
kif26ba
kinesin family member 26Ba
chr16_+_25011994 7.03 ENSDART00000157312
znf1035
zinc finger protein 1035
chr2_+_12302527 6.91 ENSDART00000091298
ENSDART00000182569
arhgap21b
Rho GTPase activating protein 21b
chr18_+_34362608 6.73 ENSDART00000131478
kcnab1a
potassium voltage-gated channel, shaker-related subfamily, beta member 1 a
chr23_-_15284757 6.60 ENSDART00000139135
sulf2b
sulfatase 2b
chr10_+_40284003 6.51 ENSDART00000062795
ENSDART00000193825
ENSDART00000113582
git2b
G protein-coupled receptor kinase interacting ArfGAP 2b
chr5_+_44064764 6.48 ENSDART00000143843
si:dkey-84j12.1
si:dkey-84j12.1
chr19_+_9459050 6.40 ENSDART00000186419
si:ch211-288g17.3
si:ch211-288g17.3
chr16_+_25107344 6.34 ENSDART00000033211
zgc:66448
zgc:66448
chr14_+_25817628 6.33 ENSDART00000047680
glra1
glycine receptor, alpha 1
chr12_+_32729470 5.55 ENSDART00000175712
rbfox3a
RNA binding fox-1 homolog 3a
chr2_-_40135942 5.52 ENSDART00000176951
ENSDART00000098632
ENSDART00000148563
ENSDART00000149895
epha4a
eph receptor A4a
chr11_+_14937904 5.43 ENSDART00000185103
CR550302.3

chr9_-_43538328 5.35 ENSDART00000140526
znf385b
zinc finger protein 385B
chr13_+_31177934 5.21 ENSDART00000144568
ptpn20
protein tyrosine phosphatase, non-receptor type 20
chr8_+_44714336 5.04 ENSDART00000145801
elmod3
ELMO/CED-12 domain containing 3
chr22_+_10698549 4.88 ENSDART00000081228
abhd14a
abhydrolase domain containing 14A
chr6_-_40466861 4.77 ENSDART00000062724
crbn
cereblon
chr5_-_63515210 4.73 ENSDART00000022348
prdm12b
PR domain containing 12b
chr8_+_17884569 4.64 ENSDART00000134660
slc44a5b
solute carrier family 44, member 5b
chr2_+_23006792 4.51 ENSDART00000027782
mknk2a
MAP kinase interacting serine/threonine kinase 2a
chr16_+_30301539 4.38 ENSDART00000186018
LO017848.1

chr10_+_38775408 4.24 ENSDART00000125045
dscama
Down syndrome cell adhesion molecule a
chr17_+_51499789 4.18 ENSDART00000187701
CABZ01067581.1

chr9_-_29003245 4.03 ENSDART00000183391
ENSDART00000188836
ptpn4a
protein tyrosine phosphatase, non-receptor type 4a
chr5_+_42381273 4.02 ENSDART00000142387
pimr58
Pim proto-oncogene, serine/threonine kinase, related 58
chr11_+_38280454 3.99 ENSDART00000171496
CDK18
si:dkey-166c18.1
chr6_-_12172424 3.88 ENSDART00000109344
tanc1a
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1a
chr3_-_33574576 3.86 ENSDART00000184881
CR847537.1

chr8_+_52314542 3.85 ENSDART00000013059
ENSDART00000125241
dbnlb
drebrin-like b
chr3_-_61362398 3.79 ENSDART00000156177
si:dkey-111k8.3
si:dkey-111k8.3
chr7_-_33960170 3.67 ENSDART00000180766
skor1a
SKI family transcriptional corepressor 1a
chr2_+_16696052 3.47 ENSDART00000022356
ENSDART00000164329
ppp1r7
protein phosphatase 1, regulatory (inhibitor) subunit 7
chr15_+_45994123 3.46 ENSDART00000124704
lrfn1
leucine rich repeat and fibronectin type III domain containing 1
chr13_+_31180084 3.34 ENSDART00000133774
ptpn20
protein tyrosine phosphatase, non-receptor type 20
chr14_+_28486213 3.23 ENSDART00000161852
stag2b
stromal antigen 2b
chr9_+_29430432 3.15 ENSDART00000125632
uggt2
UDP-glucose glycoprotein glucosyltransferase 2
chr24_+_19593197 3.10 ENSDART00000151923
slco5a1a
solute carrier organic anion transporter family member 5A1a
chr11_-_42918971 2.75 ENSDART00000052912
pcdh20
protocadherin 20
chr13_-_16066997 2.74 ENSDART00000184790
SPATA48
spermatogenesis associated 48
chr17_-_49438873 2.63 ENSDART00000004424
znf292a
zinc finger protein 292a
chr13_-_37109987 2.58 ENSDART00000136750
syne2b
spectrin repeat containing, nuclear envelope 2b
chr5_+_17624463 2.49 ENSDART00000183869
ENSDART00000081064
fbrsl1
fibrosin-like 1
chr1_+_10318089 2.44 ENSDART00000029774
pip4p1b
phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1b
chr17_-_29902187 2.18 ENSDART00000009104
esrrb
estrogen-related receptor beta
chr7_+_53498152 2.16 ENSDART00000184497
znf609b
zinc finger protein 609b
chr2_-_3045861 2.14 ENSDART00000105818
ENSDART00000187575
guk1a
guanylate kinase 1a
chr9_+_38088331 2.08 ENSDART00000123749
cacnb4a
calcium channel, voltage-dependent, beta 4a subunit
chr3_-_32169754 2.01 ENSDART00000179010
tnnt1
troponin T type 1 (skeletal, slow)
chr3_-_30384353 1.81 ENSDART00000186832
lrrc4ba
leucine rich repeat containing 4Ba
chr15_-_5720583 1.73 ENSDART00000158034
ENSDART00000190332
ENSDART00000109599
urb1
URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
chr7_-_18416741 1.62 ENSDART00000097882
sstr1b
somatostatin receptor 1b
chr10_-_29831944 1.48 ENSDART00000063923
ENSDART00000136264
zpr1
ZPR1 zinc finger
chr3_-_23406964 1.43 ENSDART00000114723
rapgefl1
Rap guanine nucleotide exchange factor (GEF)-like 1
chr11_+_44502410 1.25 ENSDART00000172998
ero1b
endoplasmic reticulum oxidoreductase beta
chr17_+_6765621 1.25 ENSDART00000156637
ENSDART00000007622
afg1la
AFG1 like ATPase a
chr21_+_36623162 1.24 ENSDART00000027459
grk6
G protein-coupled receptor kinase 6
chr7_+_32369026 1.17 ENSDART00000169588
lgr4
leucine-rich repeat containing G protein-coupled receptor 4
chr3_+_56276346 1.17 ENSDART00000157770
PRKCA
si:ch73-374l24.1
chr6_+_39184236 1.15 ENSDART00000156187
tac3b
tachykinin 3b
chr10_+_25947946 1.09 ENSDART00000064393
ufm1
ubiquitin-fold modifier 1
chr1_+_47499888 1.06 ENSDART00000027624
stn1
STN1, CST complex subunit
chr25_+_6186823 0.96 ENSDART00000153526
oaz2a
ornithine decarboxylase antizyme 2a
chr7_-_17779644 0.89 ENSDART00000128504
si:dkey-106g10.7
si:dkey-106g10.7
chr4_+_11695979 0.81 ENSDART00000137736
mkln1
muskelin 1, intracellular mediator containing kelch motifs
chr14_-_7306983 0.73 ENSDART00000158914
si:ch211-51f19.1
si:ch211-51f19.1
chr10_+_39084354 0.62 ENSDART00000158245
si:ch73-1a9.3
si:ch73-1a9.3
chr4_+_13428993 0.58 ENSDART00000067151
si:dkey-39a18.1
si:dkey-39a18.1
chr20_+_13781779 0.54 ENSDART00000142999
ENSDART00000152471
lpgat1
lysophosphatidylglycerol acyltransferase 1
chr2_-_9818640 0.53 ENSDART00000139499
ENSDART00000165548
ENSDART00000012442
ENSDART00000046587
ap2m1b
adaptor-related protein complex 2, mu 1 subunit, b
chr21_+_20396858 0.48 ENSDART00000003299
ENSDART00000146615
zgc:103482
zgc:103482
chr13_-_42400647 0.44 ENSDART00000043069
march5
membrane-associated ring finger (C3HC4) 5
chr14_-_32959851 0.40 ENSDART00000075157
chic1
cysteine-rich hydrophobic domain 1
chr5_-_24270989 0.34 ENSDART00000146251
si:ch211-137i24.12
si:ch211-137i24.12
chr17_-_12926456 0.33 ENSDART00000044126
INSM2
INSM transcriptional repressor 2
chr9_-_19699728 0.03 ENSDART00000166780
si:ch211-141e20.2
si:ch211-141e20.2

Network of associatons between targets according to the STRING database.

First level regulatory network of pou4f2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.6 30.2 GO:0019242 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
5.7 22.8 GO:0021742 abducens nucleus development(GO:0021742)
3.4 30.8 GO:0051965 positive regulation of synapse assembly(GO:0051965)
2.7 16.3 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
2.5 10.0 GO:0099543 trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by nitric oxide(GO:0099548)
2.3 11.4 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
2.1 6.3 GO:0071361 cellular response to ethanol(GO:0071361)
1.9 7.8 GO:0070987 error-free translesion synthesis(GO:0070987)
1.7 13.9 GO:0060976 coronary vasculature development(GO:0060976)
1.7 6.7 GO:1902260 negative regulation of potassium ion transmembrane transporter activity(GO:1901017) negative regulation of potassium ion transmembrane transport(GO:1901380) negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
1.6 4.7 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
1.5 7.4 GO:1901907 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
1.5 14.6 GO:1904071 presynaptic active zone assembly(GO:1904071)
1.3 11.3 GO:0001682 tRNA 5'-leader removal(GO:0001682)
1.0 9.0 GO:2000272 negative regulation of receptor activity(GO:2000272)
1.0 11.7 GO:0035094 response to nicotine(GO:0035094)
0.9 15.5 GO:0032418 lysosome localization(GO:0032418)
0.9 26.2 GO:0070593 dendrite self-avoidance(GO:0070593)
0.9 17.0 GO:0031952 regulation of protein autophosphorylation(GO:0031952)
0.8 5.5 GO:0003404 optic vesicle morphogenesis(GO:0003404)
0.8 3.8 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.7 10.5 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.6 11.9 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.6 1.7 GO:0090069 regulation of ribosome biogenesis(GO:0090069)
0.5 6.6 GO:0035860 esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.4 10.4 GO:0007631 feeding behavior(GO:0007631)
0.3 21.3 GO:0046328 regulation of JNK cascade(GO:0046328)
0.3 19.5 GO:0051781 positive regulation of cell division(GO:0051781)
0.2 8.7 GO:0006376 mRNA splice site selection(GO:0006376)
0.2 1.1 GO:1990592 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.2 1.3 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.2 8.5 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.2 3.2 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.2 6.9 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2 1.2 GO:0021886 hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888)
0.2 3.1 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 25.4 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)
0.1 5.3 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.1 0.5 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.1 1.6 GO:0071384 cellular response to corticosteroid stimulus(GO:0071384) cellular response to glucocorticoid stimulus(GO:0071385)
0.1 5.5 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 20.2 GO:0016042 lipid catabolic process(GO:0016042)
0.1 3.7 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.1 21.5 GO:0008380 RNA splicing(GO:0008380)
0.1 2.4 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 2.1 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 9.8 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 1.1 GO:0016233 telomere capping(GO:0016233)
0.0 1.0 GO:0006595 polyamine metabolic process(GO:0006595)
0.0 7.1 GO:0007018 microtubule-based movement(GO:0007018)
0.0 2.0 GO:0006937 regulation of muscle contraction(GO:0006937)
0.0 8.7 GO:0042391 regulation of membrane potential(GO:0042391)
0.0 1.3 GO:0071600 otic vesicle morphogenesis(GO:0071600)
0.0 1.8 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 4.0 GO:0006470 protein dephosphorylation(GO:0006470)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 10.5 GO:0005955 calcineurin complex(GO:0005955)
1.6 11.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
1.5 14.6 GO:0098982 GABA-ergic synapse(GO:0098982)
0.7 31.2 GO:0043204 perikaryon(GO:0043204)
0.7 4.8 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.6 13.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.6 6.7 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.5 17.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.4 32.4 GO:0005871 kinesin complex(GO:0005871)
0.4 1.1 GO:1990879 CST complex(GO:1990879)
0.3 11.9 GO:0032587 ruffle membrane(GO:0032587)
0.2 17.9 GO:0031902 late endosome membrane(GO:0031902)
0.2 30.8 GO:0005925 focal adhesion(GO:0005925)
0.1 39.4 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 6.9 GO:0016342 catenin complex(GO:0016342)
0.1 6.1 GO:0048786 presynaptic active zone(GO:0048786)
0.1 17.8 GO:0030424 axon(GO:0030424)
0.1 6.6 GO:0005795 Golgi stack(GO:0005795)
0.1 0.5 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 3.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 2.0 GO:0005861 troponin complex(GO:0005861)
0.0 5.5 GO:0005769 early endosome(GO:0005769)
0.0 14.2 GO:0031012 extracellular matrix(GO:0031012)
0.0 2.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 13.8 GO:0045202 synapse(GO:0045202)
0.0 31.1 GO:0005576 extracellular region(GO:0005576)
0.0 2.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 19.3 GO:0005829 cytosol(GO:0005829)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
7.6 30.2 GO:0008929 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
4.7 70.3 GO:0005504 fatty acid binding(GO:0005504)
2.1 10.4 GO:0031841 neuropeptide Y receptor binding(GO:0031841) type 2 neuropeptide Y receptor binding(GO:0031843)
1.8 10.5 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
1.6 4.7 GO:1990226 histone methyltransferase binding(GO:1990226)
1.5 7.4 GO:0034432 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.9 17.0 GO:0019211 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.8 20.4 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.8 14.6 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.8 26.2 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.8 25.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.7 6.3 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.7 8.5 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.6 3.2 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.6 10.5 GO:0008301 DNA binding, bending(GO:0008301)
0.4 2.1 GO:0004385 guanylate kinase activity(GO:0004385)
0.4 6.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.4 13.1 GO:0005540 hyaluronic acid binding(GO:0005540)
0.3 6.2 GO:0004383 guanylate cyclase activity(GO:0004383)
0.3 7.8 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.3 7.5 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.3 5.5 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.3 6.7 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.3 2.4 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.2 1.0 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.2 1.6 GO:0004994 somatostatin receptor activity(GO:0004994)
0.2 19.5 GO:0008201 heparin binding(GO:0008201)
0.2 3.1 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.1 1.1 GO:0043047 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.1 4.5 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 1.2 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 1.3 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 2.0 GO:0005523 tropomyosin binding(GO:0005523)
0.1 7.1 GO:0003777 microtubule motor activity(GO:0003777)
0.1 1.2 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.1 2.1 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 6.9 GO:0045296 cadherin binding(GO:0045296)
0.1 3.7 GO:0046332 SMAD binding(GO:0046332)
0.1 7.6 GO:0005516 calmodulin binding(GO:0005516)
0.0 18.7 GO:0051015 actin filament binding(GO:0051015)
0.0 17.6 GO:0005096 GTPase activator activity(GO:0005096)
0.0 2.2 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 9.0 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.0 39.1 GO:0005509 calcium ion binding(GO:0005509)
0.0 4.3 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 6.8 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.0 17.9 GO:0046983 protein dimerization activity(GO:0046983)
0.0 0.5 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 37.7 GO:0003723 RNA binding(GO:0003723)
0.0 0.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 8.5 GO:0005543 phospholipid binding(GO:0005543)
0.0 4.0 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 19.5 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.8 20.2 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.7 10.5 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.4 15.7 ST G ALPHA I PATHWAY G alpha i Pathway
0.4 11.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.2 13.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.2 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.2 PID CXCR4 PATHWAY CXCR4-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 20.4 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
1.4 17.0 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.9 13.9 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.8 10.5 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.4 16.9 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.3 6.3 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.2 3.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 2.0 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 0.5 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.1 7.8 REACTOME DNA REPAIR Genes involved in DNA Repair
0.0 2.2 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway