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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for prox1a+prox2+prox3

Z-value: 0.81

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Transcription factors associated with prox1a+prox2+prox3

Gene Symbol Gene ID Gene Info
prox2
ENSDARG00000041952 prospero homeobox 2
prox1a
ENSDARG00000055158 prospero homeobox 1a
prox3
ENSDARG00000088810 prospero homeobox 3
prox3
ENSDARG00000113014 prospero homeobox 3
prox2
ENSDARG00000117137 prospero homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
prox1adr11_v1_chr17_-_32865788_32865788-0.736.3e-17Click!
prox1bdr11_v1_chr7_-_19940473_19940473-0.232.5e-02Click!
prox2dr11_v1_chr17_-_52521002_525210020.009.9e-01Click!

Activity profile of prox1a+prox2+prox3 motif

Sorted Z-values of prox1a+prox2+prox3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_29952169 25.00 ENSDART00000173540
ENSDART00000173940
ENSDART00000173906
ENSDART00000173772
ENSDART00000173506
ENSDART00000039657
tpma
alpha-tropomyosin
chr7_+_29951997 22.03 ENSDART00000173453
tpma
alpha-tropomyosin
chr2_+_2470687 14.45 ENSDART00000184024
ENSDART00000061955
myl13
myosin, light chain 13
chr17_-_5583345 12.46 ENSDART00000035944
clic5a
chloride intracellular channel 5a
chr19_-_31042570 7.84 ENSDART00000144337
ENSDART00000136213
ENSDART00000133101
ENSDART00000190949
bzw2
basic leucine zipper and W2 domains 2
chr15_+_32711663 7.74 ENSDART00000157854
ENSDART00000167515
postnb
periostin, osteoblast specific factor b
chr25_+_19947096 6.53 ENSDART00000154221
kcna6a
potassium voltage-gated channel, shaker-related, subfamily, member 6 a
chr9_-_42696408 6.28 ENSDART00000144744
col5a2a
collagen, type V, alpha 2a
chr25_+_19947298 6.15 ENSDART00000067648
kcna6a
potassium voltage-gated channel, shaker-related, subfamily, member 6 a
chr19_+_42886413 5.41 ENSDART00000151298
arpp21
cAMP-regulated phosphoprotein, 21
chr23_-_5759242 4.83 ENSDART00000055087
phlda3
pleckstrin homology-like domain, family A, member 3
chr5_+_37517800 4.59 ENSDART00000048107
FP102018.1
Danio rerio latent transforming growth factor beta binding protein 3 (ltbp3), mRNA.
chr5_+_37785152 4.36 ENSDART00000053511
ENSDART00000189812
myo1ca
myosin Ic, paralog a
chr11_-_24681292 4.13 ENSDART00000089601
olfml3b
olfactomedin-like 3b
chr5_+_27440325 3.97 ENSDART00000185815
ENSDART00000144013
loxl2b
lysyl oxidase-like 2b
chr9_-_23033818 3.80 ENSDART00000022392
rnd3b
Rho family GTPase 3b
chr5_+_13870340 3.48 ENSDART00000160690
hk2
hexokinase 2
chr18_+_7204378 3.32 ENSDART00000142905
vwf
von Willebrand factor
chr14_+_31751260 3.08 ENSDART00000169796
si:dkeyp-11e3.1
si:dkeyp-11e3.1
chr21_-_303766 2.61 ENSDART00000150913
lhfpl2a
LHFPL tetraspan subfamily member 2a
chr8_-_47800754 2.50 ENSDART00000115050
ENSDART00000133669
kank3
KN motif and ankyrin repeat domains 3
chr3_-_59981162 2.14 ENSDART00000128790
cdr2l
cerebellar degeneration-related protein 2-like
chr23_+_16889352 2.07 ENSDART00000145275
si:dkey-147f3.8
si:dkey-147f3.8
chr10_-_8294965 2.06 ENSDART00000167380
plpp1a
phospholipid phosphatase 1a
chr13_+_7442023 2.02 ENSDART00000080975
tnfaip2b
tumor necrosis factor, alpha-induced protein 2b
chr4_+_77973876 2.01 ENSDART00000057423
terfa
telomeric repeat binding factor a
chr10_-_8295294 2.00 ENSDART00000075412
ENSDART00000163803
plpp1a
phospholipid phosphatase 1a
chr8_-_4475908 1.96 ENSDART00000191027
si:ch211-166a6.5
si:ch211-166a6.5
chr9_+_8968702 1.95 ENSDART00000008490
ube2al
ubiquitin conjugating enzyme E2 A, like
chr1_-_59065217 1.95 ENSDART00000188972
CABZ01080042.1

chr15_+_37954666 1.90 ENSDART00000126534
ENSDART00000155548
si:dkey-238d18.7
si:dkey-238d18.7
chr8_+_25616946 1.83 ENSDART00000133983
slc38a5a
solute carrier family 38, member 5a
chr23_+_21663631 1.78 ENSDART00000066125
dhrs3a
dehydrogenase/reductase (SDR family) member 3a
chr21_-_22831388 1.77 ENSDART00000151040
angptl5
angiopoietin-like 5
chr15_-_29162193 1.75 ENSDART00000138449
ENSDART00000099885
xaf1
XIAP associated factor 1
chr16_+_42772678 1.73 ENSDART00000155575
si:ch211-135n15.2
si:ch211-135n15.2
chr1_+_6161930 1.65 ENSDART00000037036
cnppd1
cyclin Pas1/PHO80 domain containing 1
chr15_-_23475051 1.62 ENSDART00000152460
nlrx1
NLR family member X1
chr17_-_21832119 1.60 ENSDART00000153539
ENSDART00000079008
si:ch211-208g24.8
si:ch211-208g24.8
chr5_-_61638125 1.60 ENSDART00000134314
si:dkey-261j4.3
si:dkey-261j4.3
chr2_+_6885852 1.59 ENSDART00000016607
rgs5b
regulator of G protein signaling 5b
chr12_-_23365737 1.55 ENSDART00000170376
mpp7a
membrane protein, palmitoylated 7a (MAGUK p55 subfamily member 7)
chr20_-_54014373 1.47 ENSDART00000152934
si:dkey-241l7.6
si:dkey-241l7.6
chr16_-_54919260 1.44 ENSDART00000156533
kdf1a
keratinocyte differentiation factor 1a
chr12_+_27117609 1.40 ENSDART00000076154
hoxb8b
homeobox B8b
chr20_+_192170 1.38 ENSDART00000189675
cx28.8
connexin 28.8
chr8_-_49345388 1.38 ENSDART00000053203
plp2
proteolipid protein 2
chr25_+_8407892 1.31 ENSDART00000153536
muc5.2
mucin 5.2
chr7_-_25934540 1.21 ENSDART00000192761
BX005022.2

chr5_+_42136359 1.20 ENSDART00000083731
trpv1
transient receptor potential cation channel, subfamily V, member 1
chr17_+_48164536 1.17 ENSDART00000161750
ENSDART00000156923
plekhd1
pleckstrin homology domain containing, family D (with coiled-coil domains) member 1
chr3_+_11072958 1.16 ENSDART00000158899
mrps7
mitochondrial ribosomal protein S7
chr12_-_4408828 1.08 ENSDART00000152447
si:ch211-173d10.1
si:ch211-173d10.1
chr19_-_22621811 1.06 ENSDART00000090669
pleca
plectin a
chr14_+_24840669 1.00 ENSDART00000106039
arhgef37
Rho guanine nucleotide exchange factor (GEF) 37
chr13_-_27384697 0.98 ENSDART00000146230
kcnq5a
potassium voltage-gated channel, KQT-like subfamily, member 5a
chr12_-_18898413 0.96 ENSDART00000181281
ENSDART00000121866
desi1b
desumoylating isopeptidase 1b
chr4_+_30788743 0.94 ENSDART00000184557
si:dkey-178j11.5
si:dkey-178j11.5
chr7_+_19562045 0.86 ENSDART00000077545
slc7a7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr9_+_38684871 0.86 ENSDART00000147938
ENSDART00000004462
heg1
heart development protein with EGF-like domains 1
chr14_-_28566238 0.85 ENSDART00000172547
insb
preproinsulin b
chr20_-_14924858 0.84 ENSDART00000047039
dnm3a
dynamin 3a
chr19_-_22621991 0.78 ENSDART00000175106
pleca
plectin a
chr16_+_11779761 0.77 ENSDART00000140297
si:dkey-250k15.4
si:dkey-250k15.4
chr15_+_2190229 0.75 ENSDART00000147710
rsrc1
arginine/serine-rich coiled-coil 1
chr12_+_6065661 0.75 ENSDART00000142418
sgms1
sphingomyelin synthase 1
chr13_+_47050726 0.73 ENSDART00000140045
anapc1
anaphase promoting complex subunit 1
chr5_-_51484156 0.71 ENSDART00000162064
CR388055.1

chr5_+_22510639 0.70 ENSDART00000080919
rpl36a
ribosomal protein L36A
chr17_-_106291 0.70 ENSDART00000160738
arhgap11a
Rho GTPase activating protein 11A
chr6_-_34006917 0.65 ENSDART00000190702
ENSDART00000184003
tie1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr22_+_9287929 0.65 ENSDART00000193522
si:ch211-250k18.7
si:ch211-250k18.7
chr15_-_31177324 0.64 ENSDART00000008854
wsb1
WD repeat and SOCS box containing 1
chr19_+_7929704 0.58 ENSDART00000147015
si:dkey-266f7.4
si:dkey-266f7.4
chr3_+_22335030 0.56 ENSDART00000055676
zgc:103564
zgc:103564
chr25_-_10630496 0.56 ENSDART00000153639
ENSDART00000181722
ENSDART00000177834
ppp6r3
protein phosphatase 6, regulatory subunit 3
chr4_-_50933168 0.53 ENSDART00000150296
si:ch211-208f21.3
si:ch211-208f21.3
chr4_-_75899294 0.45 ENSDART00000157887
si:dkey-261j11.3
si:dkey-261j11.3
chr14_-_30971264 0.44 ENSDART00000010512
zgc:92907
zgc:92907
chrM_+_9052 0.44 ENSDART00000093612
mt-atp6
ATP synthase 6, mitochondrial
chr4_+_47789703 0.43 ENSDART00000161323
si:ch211-196h24.2
si:ch211-196h24.2
chr9_+_1138802 0.42 ENSDART00000191130
ENSDART00000187308
slc15a1a
solute carrier family 15 (oligopeptide transporter), member 1a
chr23_+_35672542 0.41 ENSDART00000046268
pmelb
premelanosome protein b
chr18_+_33264609 0.41 ENSDART00000050639
v2ra20
vomeronasal 2 receptor, a20
chr9_+_1138323 0.39 ENSDART00000190352
ENSDART00000190387
slc15a1a
solute carrier family 15 (oligopeptide transporter), member 1a
chr10_+_6697369 0.38 ENSDART00000148606
si:ch211-57m13.8
si:ch211-57m13.8
chr22_+_9239831 0.27 ENSDART00000133720
si:ch211-250k18.5
si:ch211-250k18.5
chr7_+_6941583 0.24 ENSDART00000160709
ENSDART00000157634
rbm14b
RNA binding motif protein 14b
chr14_+_9287683 0.23 ENSDART00000122485
msnb
moesin b
chr4_+_5196469 0.17 ENSDART00000067386
rad51ap1
RAD51 associated protein 1
chr9_-_53817143 0.17 ENSDART00000148764
ENSDART00000075537
ednrbb
endothelin receptor type Bb
chr1_-_9485939 0.17 ENSDART00000157814
micall2b
mical-like 2b
chr14_+_28473173 0.13 ENSDART00000017075
xiap
X-linked inhibitor of apoptosis
chr6_+_11250033 0.10 ENSDART00000065411
ENSDART00000132677
atg9a
ATG9 autophagy related 9 homolog A (S. cerevisiae)
chr1_-_9486214 0.09 ENSDART00000137821
micall2b
mical-like 2b
chr10_+_43037064 0.06 ENSDART00000160159
atg10
ATG10 autophagy related 10 homolog (S. cerevisiae)
chr4_-_71551644 0.02 ENSDART00000168064
si:dkey-27n6.1
si:dkey-27n6.1
chr4_+_3455665 0.01 ENSDART00000058277
znf800b
zinc finger protein 800b
chr13_-_31866276 0.00 ENSDART00000140164
syt14a
synaptotagmin XIVa

Network of associatons between targets according to the STRING database.

First level regulatory network of prox1a+prox2+prox3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.0 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.5 2.0 GO:0032207 regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208)
0.5 1.8 GO:0089709 L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.5 47.9 GO:0061515 myeloid cell development(GO:0061515)
0.4 4.8 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.4 7.7 GO:0016203 muscle attachment(GO:0016203)
0.3 2.6 GO:0046546 development of primary male sexual characteristics(GO:0046546)
0.3 1.4 GO:0010481 epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.2 3.5 GO:0001678 cellular glucose homeostasis(GO:0001678)
0.2 2.0 GO:0051601 exocyst localization(GO:0051601)
0.2 2.0 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.1 1.8 GO:0042572 retinol metabolic process(GO:0042572)
0.1 1.8 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.7 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 12.5 GO:0006821 chloride transport(GO:0006821)
0.1 0.8 GO:0006857 oligopeptide transport(GO:0006857)
0.1 2.1 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.1 10.8 GO:0051260 protein homooligomerization(GO:0051260)
0.1 4.4 GO:0030050 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.1 0.7 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.1 1.6 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.1 1.2 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.1 1.2 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 4.1 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.1 2.0 GO:0016574 histone ubiquitination(GO:0016574)
0.0 0.8 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.0 0.4 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 3.3 GO:0007596 blood coagulation(GO:0007596)
0.0 3.8 GO:0030865 cortical cytoskeleton organization(GO:0030865)
0.0 1.7 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 2.5 GO:0032272 negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272)
0.0 0.6 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0 0.4 GO:0032438 melanosome organization(GO:0032438)
0.0 6.3 GO:0030198 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0 0.7 GO:0007091 metaphase/anaphase transition of mitotic cell cycle(GO:0007091)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.3 GO:0005588 collagen type V trimer(GO:0005588)
1.1 4.4 GO:0060171 stereocilium membrane(GO:0060171)
0.4 2.0 GO:0033503 HULC complex(GO:0033503)
0.4 46.4 GO:0005884 actin filament(GO:0005884)
0.2 12.5 GO:0034707 chloride channel complex(GO:0034707)
0.2 13.7 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1 2.0 GO:0070187 telosome(GO:0070187)
0.1 1.8 GO:0030056 hemidesmosome(GO:0030056)
0.1 4.1 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.1 1.2 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 2.0 GO:0000145 exocyst(GO:0000145)
0.1 1.2 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.8 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.0 16.3 GO:0031012 extracellular matrix(GO:0031012)
0.0 1.8 GO:0005811 lipid particle(GO:0005811)
0.0 1.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 3.8 GO:0005938 cell cortex(GO:0005938)
0.0 1.6 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.4 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
1.4 4.1 GO:0000810 diacylglycerol diphosphate phosphatase activity(GO:0000810)
0.6 3.5 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) glucose binding(GO:0005536) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.3 45.8 GO:0042803 protein homodimerization activity(GO:0042803)
0.3 13.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.2 4.0 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.2 1.8 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.2 1.8 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.1 1.8 GO:0030506 ankyrin binding(GO:0030506)
0.1 12.5 GO:0005254 chloride channel activity(GO:0005254)
0.1 0.7 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 0.8 GO:0071916 dipeptide transporter activity(GO:0042936) dipeptide transmembrane transporter activity(GO:0071916)
0.1 1.9 GO:0033691 sialic acid binding(GO:0033691)
0.1 0.9 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.1 4.4 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 6.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 7.7 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 1.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.2 GO:0004962 endothelin receptor activity(GO:0004962)
0.0 1.2 GO:0019843 rRNA binding(GO:0019843)
0.0 1.0 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.1 GO:0019777 Atg12 transferase activity(GO:0019777)
0.0 2.2 GO:0005179 hormone activity(GO:0005179)
0.0 2.5 GO:0019901 protein kinase binding(GO:0019901)
0.0 12.3 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.5 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.2 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.7 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 3.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.8 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.3 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 3.5 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.1 1.8 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 1.6 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.9 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.7 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.7 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis