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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for prrx1a+prrx1b

Z-value: 1.10

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Transcription factors associated with prrx1a+prrx1b

Gene Symbol Gene ID Gene Info
ENSDARG00000033971 paired related homeobox 1a
ENSDARG00000042027 paired related homeobox 1b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
prrx1bdr11_v1_chr20_+_34512130_34512130-0.542.4e-08Click!
prrx1adr11_v1_chr2_-_23172708_23172708-0.413.3e-05Click!

Activity profile of prrx1a+prrx1b motif

Sorted Z-values of prrx1a+prrx1b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr25_+_31276842 37.84 ENSDART00000187238
troponin I type 2a (skeletal, fast), tandem duplicate 4
chr19_-_3167729 10.89 ENSDART00000110763
ENSDART00000145710
ENSDART00000074620
ENSDART00000105174
starmaker
chr25_+_31267268 9.80 ENSDART00000181239
troponin I type 2a (skeletal, fast), tandem duplicate 3
chr25_-_13381854 7.16 ENSDART00000164621
ENSDART00000169129
NDRG family member 4
chr23_-_24343363 7.10 ENSDART00000166392
family with sequence similarity 131, member C
chr25_+_31277415 7.06 ENSDART00000036275
troponin I type 2a (skeletal, fast), tandem duplicate 4
chr2_+_38039857 6.96 ENSDART00000159951
calsequestrin 1a
chr15_-_16098531 6.77 ENSDART00000080377
aldolase C, fructose-bisphosphate, a
chr4_+_9669717 6.71 ENSDART00000004604
si:dkey-153k10.9
chr21_+_27382893 6.69 ENSDART00000005682
actinin alpha 3a
chr24_-_38079261 6.68 ENSDART00000105662
C-reactive protein 1
chr12_+_2428247 6.66 ENSDART00000152529
leucine rich repeat containing 18b
chr6_+_23887314 6.60 ENSDART00000163188
zinc finger protein 648
chr13_+_24279021 6.30 ENSDART00000058629
actin, alpha 1b, skeletal muscle
chr18_-_47662696 6.22 ENSDART00000184260

chr1_+_17676745 6.05 ENSDART00000030665
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
chr6_+_40354424 5.92 ENSDART00000047416
solute carrier family 4, sodium bicarbonate cotransporter, member 8
chr12_-_558201 5.82 ENSDART00000168586
ENSDART00000158355
brain specific kinase 146
chr11_-_37509001 5.57 ENSDART00000109753
bassoon (presynaptic cytomatrix protein) b
chr1_+_25801648 5.25 ENSDART00000129471
guanylate cyclase 1 soluble subunit beta 1
chr8_+_3820134 5.18 ENSDART00000122454
citron rho-interacting serine/threonine kinase b
chr4_-_14315855 5.07 ENSDART00000133325
neural EGFL like 2b
chr11_+_36243774 5.03 ENSDART00000023323
zgc:172270
chr9_-_48397702 4.84 ENSDART00000147169
zgc:172182
chr5_-_31901468 4.81 ENSDART00000147814
ENSDART00000141446
coronin, actin binding protein, 1Cb
chr25_+_26921480 4.63 ENSDART00000155949
glutamate receptor, metabotropic 8b
chr2_+_30916188 4.52 ENSDART00000137012
myomesin 1a (skelemin)
chr14_+_19258702 4.44 ENSDART00000187087
ENSDART00000005738
SLIT and NTRK-like family, member 2
chr13_-_29421331 4.43 ENSDART00000150228
choline O-acetyltransferase a
chr18_-_21271373 4.41 ENSDART00000060001
purine nucleoside phosphorylase 6
chr19_+_31771270 4.39 ENSDART00000147474
stathmin 2b
chr15_-_44512461 4.38 ENSDART00000155456
glutamate receptor, ionotropic, AMPA 4a
chr21_+_13861589 4.36 ENSDART00000015629
ENSDART00000171306
syntaxin binding protein 1a
chr12_+_18681477 4.32 ENSDART00000127981
ENSDART00000143979
regulator of G protein signaling 9b
chr17_-_14726824 4.00 ENSDART00000162947
si:ch73-305o9.3
chr21_+_3093419 3.98 ENSDART00000162520
SHC adaptor protein 3
chr20_-_27225876 3.97 ENSDART00000149204
ENSDART00000149732
si:dkey-85n7.7
chr8_-_53195500 3.96 ENSDART00000132000
gamma-aminobutyric acid (GABA) A receptor, delta
chr21_+_19008168 3.92 ENSDART00000136196
ENSDART00000128381
ENSDART00000176624
neurofilament, light polypeptide a
chr18_-_26785861 3.90 ENSDART00000098361
neuromedin Ba
chr20_-_9462433 3.86 ENSDART00000152674
ENSDART00000040557
zgc:101840
chr22_+_20208185 3.72 ENSDART00000142748
si:dkey-110c1.7
chr2_-_39558643 3.69 ENSDART00000139860
ENSDART00000145231
ENSDART00000141721
cerebellin 7
chr17_-_15657029 3.68 ENSDART00000153925
fucosyltransferase 9a
chr10_-_26744131 3.66 ENSDART00000020096
ENSDART00000162710
ENSDART00000179853
fibroblast growth factor 13b
chr16_-_16590780 3.66 ENSDART00000059841
si:ch211-257p13.3
chr2_+_23823622 3.64 ENSDART00000099581
si:dkey-24c2.9
chr18_+_1703984 3.61 ENSDART00000114010
SLIT and NTRK-like family, member 3a
chr21_-_27881752 3.60 ENSDART00000132583
neurexin 2a
chr16_-_27640995 3.60 ENSDART00000019658
NAC alpha domain containing
chr22_-_32507966 3.58 ENSDART00000104693
poly(rC) binding protein 4
chr25_+_22730490 3.58 ENSDART00000149455
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr1_-_45553602 3.57 ENSDART00000143664
glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b
chr1_+_18811679 3.56 ENSDART00000078610
solute carrier family 25, member 51a
chr25_+_29160102 3.56 ENSDART00000162854
pyruvate kinase M1/2b
chr23_-_12345764 3.56 ENSDART00000133956
phosphatase and actin regulator 3a
chr1_-_18811517 3.49 ENSDART00000142026
si:dkey-167i21.2
chr21_+_13366353 3.45 ENSDART00000151630
si:ch73-62l21.1
chr23_+_45584223 3.40 ENSDART00000149367
si:ch73-290k24.5
chr17_-_37214196 3.40 ENSDART00000128715
kinesin family member 3Cb
chr8_+_41647539 3.28 ENSDART00000136492
ENSDART00000138799
ENSDART00000134404
si:ch211-158d24.4
chr1_-_10647484 3.28 ENSDART00000164541
ENSDART00000188958
ENSDART00000190904
si:dkey-31e10.1
chr6_+_49412754 3.25 ENSDART00000027398
potassium voltage-gated channel, shaker-related subfamily, member 2a
chr10_+_3299829 3.24 ENSDART00000183684
zgc:56235
chr24_-_38657683 3.20 ENSDART00000154843
si:ch1073-164k15.3
chr9_-_48407408 3.17 ENSDART00000058248
zgc:172182
chr15_+_22435460 3.09 ENSDART00000031976
transmembrane protein 136a
chr23_+_26026383 3.08 ENSDART00000141553
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr24_-_7697274 3.07 ENSDART00000186077
synaptotagmin Vb
chr10_-_34772211 3.06 ENSDART00000145450
ENSDART00000134307
doublecortin-like kinase 1a
chr19_-_25113660 3.06 ENSDART00000035538
protein tyrosine phosphatase type IVA, member 3
chr7_-_69983462 3.03 ENSDART00000123380
potassium voltage-gated channel interacting protein 4
chr17_-_16965809 3.01 ENSDART00000153697
neurexin 3a
chr12_-_47601845 3.00 ENSDART00000169548
ENSDART00000182889
regulator of G protein signaling 7b
chr9_+_29603649 2.95 ENSDART00000140477
mcf.2 cell line derived transforming sequence-like b
chr16_-_42872571 2.92 ENSDART00000154757
ENSDART00000102345
thioredoxin interacting protein b
chr24_-_38384432 2.91 ENSDART00000140739
leucine rich repeat containing 4Bb
chr8_-_7391721 2.90 ENSDART00000149836
LHFPL tetraspan subfamily member 4b
chr3_-_55404985 2.89 ENSDART00000154274
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Ga
chr9_+_13733468 2.88 ENSDART00000165954
ENSDART00000160355
ENSDART00000081040
ENSDART00000138254
ENSDART00000081015
ENSDART00000141314
abl-interactor 2a
chr5_+_37966505 2.81 ENSDART00000127648
platelet-activating factor acetylhydrolase 1b, catalytic subunit 2
chr22_+_18389271 2.81 ENSDART00000088270
YjeF N-terminal domain containing 3
chr14_-_49063157 2.77 ENSDART00000021260
septin 8b
chr7_-_52334840 2.76 ENSDART00000174173

chr17_-_26926577 2.74 ENSDART00000050202
regulator of calcineurin 3
chr25_+_33002963 2.69 ENSDART00000187366

chr2_+_38554260 2.68 ENSDART00000171527
cadherin 24, type 2b
chr20_-_45423498 2.66 ENSDART00000098424
tribbles pseudokinase 2
chr2_-_9489611 2.66 ENSDART00000146715
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr9_-_394088 2.64 ENSDART00000169014
si:dkey-11f4.7
chr12_-_32013125 2.64 ENSDART00000153355
glutamate receptor, ionotropic, N-methyl D-aspartate 2Cb
chr1_+_10018466 2.60 ENSDART00000113551
tripartite motif containing 2b
chr19_-_28130658 2.59 ENSDART00000079114
iroquois homeobox 1b
chr6_+_55285578 2.57 ENSDART00000180183
zgc:109913
chr21_-_43022048 2.57 ENSDART00000138329
dihydropyrimidinase-like 3
chr16_+_1100559 2.55 ENSDART00000092657
ADAM metallopeptidase with thrombospondin type 1 motif, 16
chr4_-_23963838 2.53 ENSDART00000133433
ENSDART00000132615
ENSDART00000135942
ENSDART00000139439
cugbp, Elav-like family member 2
chr5_+_51079504 2.53 ENSDART00000097466
family with sequence similarity 169, member Aa
chr20_+_34717403 2.51 ENSDART00000034252
prepronociceptin b
chr24_+_22485710 2.50 ENSDART00000146058
si:dkey-40h20.1
chr19_-_5103313 2.47 ENSDART00000037007
triosephosphate isomerase 1a
chr23_-_18913032 2.45 ENSDART00000136678
si:ch211-209j10.6
chr4_-_5019113 2.43 ENSDART00000189321
ENSDART00000081990
striatin interacting protein 2
chr20_+_31287356 2.40 ENSDART00000007688
solute carrier family 22 (organic cation/carnitine transporter), member 16
chr6_+_6924637 2.40 ENSDART00000065551
ENSDART00000151393
sterile alpha motif and leucine zipper containing kinase AZK
chr6_+_32882821 2.40 ENSDART00000075780
growth hormone releasing hormone receptor b
chr1_-_49250490 2.35 ENSDART00000150386
si:ch73-6k14.2
chr19_-_41371978 2.29 ENSDART00000166063
ENSDART00000170343
solute carrier family 25 (aspartate/glutamate carrier), member 13
chr6_+_58698475 2.29 ENSDART00000056138
immunoglobulin superfamily, member 8
chr22_-_15562933 2.29 ENSDART00000141528
ankyrin repeat and MYND domain containing 1
chr23_-_44466257 2.27 ENSDART00000150126
si:ch1073-228j22.2
chr13_+_18331509 2.27 ENSDART00000181918
zgc:110319
chr24_-_17067284 2.27 ENSDART00000111237
armadillo repeat containing 3
chr10_-_10607118 2.26 ENSDART00000101089
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr16_+_22654481 2.23 ENSDART00000179762
cholinergic receptor, nicotinic, beta 2b
chr24_-_21923930 2.18 ENSDART00000131944
transgelin 3b
chr23_-_18707418 2.17 ENSDART00000144668
ENSDART00000141205
ENSDART00000016765
zgc:103759
chr7_-_17028015 2.17 ENSDART00000022441
developing brain homeobox 1a
chr19_-_3240605 2.16 ENSDART00000105168
si:ch211-133n4.4
chr5_+_40299568 2.15 ENSDART00000142157
ADP-ribosylation factor-like 15a
chr10_-_34741738 2.14 ENSDART00000163072
doublecortin-like kinase 1a
chr2_-_50966124 2.14 ENSDART00000170470
growth hormone releasing hormone receptor a
chr1_-_42289704 2.14 ENSDART00000150124
si:ch211-71k14.1
chr21_-_10446405 2.13 ENSDART00000167948
hyperpolarization activated cyclic nucleotide-gated potassium channel 1
chr16_+_50434668 2.13 ENSDART00000193500
zgc:110372
chr12_+_16281312 2.10 ENSDART00000152500
protein phosphatase 1, regulatory subunit 3Cb
chr24_-_11309477 2.10 ENSDART00000137257
myosin VIIA and Rab interacting protein
chr10_-_2524917 2.10 ENSDART00000188642

chr2_-_38284648 2.10 ENSDART00000148281
ENSDART00000132621
si:ch211-14a17.7
chr2_-_10188598 2.07 ENSDART00000189122
diencephalon/mesencephalon homeobox 1a
chr11_-_37425407 2.05 ENSDART00000160911
ELKS/RAB6-interacting/CAST family member 2
chr9_-_27649406 2.05 ENSDART00000181270
ENSDART00000187112
syntaxin binding protein 5-like
chr25_-_210730 2.04 ENSDART00000187580

chr20_+_23173710 2.00 ENSDART00000074172
sarcoglycan, beta (dystrophin-associated glycoprotein)
chr8_-_44868020 2.00 ENSDART00000142712
calcium channel, voltage-dependent, L type, alpha 1F subunit a
chr7_-_27685365 2.00 ENSDART00000188342
calcitonin/calcitonin-related polypeptide, alpha
chr15_-_14884332 1.99 ENSDART00000165237
si:ch211-24o8.4
chr16_-_41439659 1.97 ENSDART00000191624
copine IVa
chr17_+_6828550 1.96 ENSDART00000153777
si:ch73-242m19.1
chr7_+_29167744 1.95 ENSDART00000076345
solute carrier family 38, member 8b
chr7_+_15872357 1.95 ENSDART00000165757
paired box 6b
chr21_-_17482465 1.94 ENSDART00000004548
BarH-like homeobox 1b
chr2_+_15203322 1.93 ENSDART00000144171
ATP-binding cassette, sub-family A (ABC1), member 4b
chr6_+_37894220 1.93 ENSDART00000087311
oculocutaneous albinism II
chr11_+_6902306 1.92 ENSDART00000075993
CREB regulated transcription coactivator 1b
chr20_+_42978499 1.92 ENSDART00000138793
si:ch211-203k16.3
chr14_-_34044369 1.92 ENSDART00000149396
ENSDART00000123607
ENSDART00000190746
cytoplasmic FMR1 interacting protein 2
chr13_-_11035420 1.91 ENSDART00000108709
centrosomal protein 170Aa
chr14_-_46173265 1.91 ENSDART00000164321
zmp:0000000758
chr9_+_36314867 1.90 ENSDART00000176763
low density lipoprotein receptor-related protein 1Bb
chr16_-_27174373 1.90 ENSDART00000166681
ferric-chelate reductase 1-like
chr4_+_9279784 1.88 ENSDART00000014897
SLIT-ROBO Rho GTPase activating protein 1b
chr7_+_56098590 1.87 ENSDART00000098453
cadherin 15, type 1, M-cadherin (myotubule)
chr20_-_30920356 1.87 ENSDART00000022951
kinesin family member 25
chr4_+_5835393 1.86 ENSDART00000055414
peroxisomal biogenesis factor 26
chr1_-_50859053 1.86 ENSDART00000132779
ENSDART00000137648
si:dkeyp-123h10.2
chr19_+_37701450 1.86 ENSDART00000087694
thrombospondin, type I, domain containing 7Aa
chr6_+_52350443 1.83 ENSDART00000151612
ENSDART00000151349
si:ch211-239j9.1
chr5_+_36781732 1.82 ENSDART00000087191
MAP/microtubule affinity-regulating kinase 4a
chr3_-_24980067 1.82 ENSDART00000048871
desumoylating isopeptidase 1a
chr15_-_14625373 1.82 ENSDART00000171841
solute carrier family 5 (sodium/glucose cotransporter), member 2
chr19_+_9174166 1.80 ENSDART00000104637
ENSDART00000150968
si:ch211-81a5.8
chr16_+_20161805 1.80 ENSDART00000192146
chromosome 16 C2orf66 homolog
chr19_-_47323267 1.80 ENSDART00000190077

chr20_-_43775495 1.80 ENSDART00000100610
ENSDART00000149001
ENSDART00000148809
ENSDART00000100608
matrilin 3a
chr7_+_854237 1.77 ENSDART00000181029
zgc:175177
chr24_-_23942722 1.75 ENSDART00000080810
aristaless related homeobox a
chr1_-_10647307 1.75 ENSDART00000103548
si:dkey-31e10.1
chr18_+_33171765 1.75 ENSDART00000064153
si:ch73-125k17.2
chr7_+_35075847 1.74 ENSDART00000193469
ENSDART00000037346
chymotrypsinogen B1
chr4_+_39742119 1.71 ENSDART00000176004

chr2_+_55429988 1.70 ENSDART00000166920
adaptor-related protein complex 1, mu 1 subunit
chr9_+_47966167 1.69 ENSDART00000183345
G protein-coupled bile acid receptor 1
chr6_-_3573716 1.68 ENSDART00000026693
diencephalon/mesencephalon homeobox 1b
chr25_+_26895394 1.68 ENSDART00000155820
si:dkey-42p14.3
chr13_-_2520843 1.68 ENSDART00000187313
ENSDART00000170333
COX20 cytochrome c oxidase assembly factor
chr10_+_41765944 1.67 ENSDART00000171484
ring finger protein 34b
chr13_-_31622195 1.66 ENSDART00000057432
SIX homeobox 1a
chr3_+_46628885 1.66 ENSDART00000006602
phosphodiesterase 4A, cAMP-specific
chr8_+_35212233 1.66 ENSDART00000111021
si:dkeyp-14d3.1
chr9_+_48219111 1.65 ENSDART00000111225
ENSDART00000145972
coiled-coil domain containing 173
chr14_-_31893996 1.65 ENSDART00000173222
G protein-coupled receptor 101
chr3_+_32594357 1.65 ENSDART00000151639
unc-119 lipid binding chaperone B homolog 2
chr19_+_4139065 1.64 ENSDART00000172524
si:dkey-218f9.10
chr11_+_24001993 1.63 ENSDART00000168215
chitinase, acidic.2
chr4_-_5018705 1.63 ENSDART00000154025
striatin interacting protein 2
chr7_-_69636502 1.61 ENSDART00000126739
tetraspanin 5a
chr1_-_44899287 1.61 ENSDART00000187522
T cell immune regulator 1, ATPase H+ transporting V0 subunit a3a
chr9_+_29548195 1.59 ENSDART00000176057
ring finger protein 17
chr3_+_34919810 1.58 ENSDART00000055264
carbonic anhydrase Xb
chr23_+_579893 1.58 ENSDART00000189098

chr13_-_14487524 1.56 ENSDART00000141103
GDNF family receptor alpha 4a
chr5_+_42400777 1.54 ENSDART00000183114

chr22_+_1556948 1.54 ENSDART00000159050
si:ch211-255f4.8
chr1_-_40911332 1.54 ENSDART00000027463
H6 family homeobox 4
chr25_+_5755314 1.54 ENSDART00000172088
ENSDART00000164208
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
chr6_+_8315050 1.52 ENSDART00000189987
glutaryl-CoA dehydrogenase a
chr10_+_29698467 1.51 ENSDART00000163402
discs, large homolog 2 (Drosophila)
chr11_-_42554290 1.51 ENSDART00000130573
ATPase H+ transporting accessory protein 1 like a
chr10_-_28835771 1.48 ENSDART00000192220
ENSDART00000188436
activated leukocyte cell adhesion molecule a

Network of associatons between targets according to the STRING database.

First level regulatory network of prrx1a+prrx1b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 7.0 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722) regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
1.6 10.9 GO:0045299 otolith mineralization(GO:0045299)
1.5 6.0 GO:0015868 intracellular nucleoside transport(GO:0015859) purine nucleoside transmembrane transport(GO:0015860) purine nucleotide transport(GO:0015865) ATP transport(GO:0015867) purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503) mitochondrial ATP transmembrane transport(GO:1990544)
1.5 4.4 GO:0008292 acetylcholine biosynthetic process(GO:0008292) acetate ester biosynthetic process(GO:1900620)
1.3 5.3 GO:0099543 trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by nitric oxide(GO:0099548)
1.0 49.3 GO:0003009 skeletal muscle contraction(GO:0003009)
0.9 3.7 GO:0019242 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.9 2.7 GO:0015695 organic cation transport(GO:0015695)
0.8 2.3 GO:0006589 octopamine biosynthetic process(GO:0006589) dopamine catabolic process(GO:0042420) norepinephrine biosynthetic process(GO:0042421) octopamine metabolic process(GO:0046333)
0.7 3.6 GO:0048025 negative regulation of RNA splicing(GO:0033119) negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.7 2.8 GO:0010874 regulation of cholesterol efflux(GO:0010874)
0.6 1.9 GO:0060292 long term synaptic depression(GO:0060292)
0.6 3.7 GO:0016081 synaptic vesicle docking(GO:0016081) presynaptic dense core granule exocytosis(GO:0099525)
0.6 5.6 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.5 9.9 GO:0051764 actin crosslink formation(GO:0051764)
0.5 7.2 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.5 1.9 GO:0045046 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.4 1.8 GO:0061549 sympathetic ganglion development(GO:0061549)
0.4 1.3 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.4 1.8 GO:0003322 pancreatic A cell development(GO:0003322)
0.4 1.7 GO:0014856 skeletal muscle cell proliferation(GO:0014856) regulation of skeletal muscle cell proliferation(GO:0014857)
0.4 2.9 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.4 1.2 GO:0034375 high-density lipoprotein particle remodeling(GO:0034375)
0.4 3.9 GO:0070836 membrane raft assembly(GO:0001765) membrane raft organization(GO:0031579) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.4 4.2 GO:0030431 sleep(GO:0030431)
0.4 2.7 GO:2001270 negative regulation of execution phase of apoptosis(GO:1900118) regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001270) negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.4 3.0 GO:0071632 optomotor response(GO:0071632)
0.4 1.1 GO:0060898 eye field cell fate commitment involved in camera-type eye formation(GO:0060898)
0.3 1.4 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.3 1.0 GO:1904377 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004) positive regulation of protein localization to plasma membrane(GO:1903078) positive regulation of protein localization to cell periphery(GO:1904377)
0.3 6.6 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.3 3.3 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.3 2.3 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.3 2.6 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.3 6.8 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.3 1.9 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.3 4.1 GO:0055117 regulation of cardiac muscle contraction(GO:0055117)
0.3 3.7 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.3 5.9 GO:0015701 bicarbonate transport(GO:0015701)
0.3 4.0 GO:0036065 fucosylation(GO:0036065)
0.3 1.0 GO:0001774 microglial cell activation(GO:0001774)
0.2 1.2 GO:0051703 social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
0.2 0.7 GO:0045579 positive regulation of B cell differentiation(GO:0045579)
0.2 0.9 GO:0043374 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.2 2.3 GO:0043490 acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.2 3.9 GO:0046887 positive regulation of hormone secretion(GO:0046887)
0.2 1.3 GO:0097101 blood vessel endothelial cell fate specification(GO:0097101)
0.2 0.9 GO:0051012 microtubule sliding(GO:0051012)
0.2 1.3 GO:0003232 bulbus arteriosus development(GO:0003232)
0.2 1.9 GO:0042438 melanin biosynthetic process(GO:0042438)
0.2 2.7 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.2 2.2 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
0.2 1.2 GO:0021877 forebrain neuron fate commitment(GO:0021877)
0.2 3.8 GO:0061074 regulation of neural retina development(GO:0061074)
0.2 0.8 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.2 0.6 GO:0097264 self proteolysis(GO:0097264)
0.2 1.5 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.2 2.6 GO:0016199 axon midline choice point recognition(GO:0016199)
0.2 1.5 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.2 2.1 GO:1990709 presynaptic active zone organization(GO:1990709)
0.2 2.2 GO:0016074 snoRNA metabolic process(GO:0016074)
0.2 1.9 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.2 11.0 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.2 0.3 GO:0048320 axial mesoderm formation(GO:0048320) axial mesodermal cell differentiation(GO:0048321) axial mesodermal cell fate commitment(GO:0048322) axial mesodermal cell fate specification(GO:0048327)
0.2 2.3 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.2 3.1 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.2 3.2 GO:1902017 regulation of cilium assembly(GO:1902017)
0.2 1.1 GO:0034389 lipid particle organization(GO:0034389)
0.1 1.6 GO:0006032 chitin catabolic process(GO:0006032)
0.1 0.9 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.1 4.9 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.1 2.2 GO:0021988 olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988)
0.1 1.4 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.1 2.3 GO:0035803 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.1 0.9 GO:1901673 regulation of mitotic spindle assembly(GO:1901673)
0.1 1.5 GO:1900052 regulation of isoprenoid metabolic process(GO:0019747) regulation of vitamin metabolic process(GO:0030656) regulation of retinoic acid biosynthetic process(GO:1900052)
0.1 1.9 GO:0001964 startle response(GO:0001964)
0.1 0.5 GO:0061113 pancreas morphogenesis(GO:0061113)
0.1 1.0 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.1 4.4 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.1 0.8 GO:0060221 retinal rod cell differentiation(GO:0060221)
0.1 1.2 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.1 0.9 GO:2000650 negative regulation of sodium ion transmembrane transporter activity(GO:2000650)
0.1 0.9 GO:1901339 regulation of store-operated calcium channel activity(GO:1901339)
0.1 1.5 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 0.8 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.1 0.6 GO:0014028 notochord formation(GO:0014028)
0.1 2.1 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.1 1.0 GO:0043046 DNA methylation involved in gamete generation(GO:0043046)
0.1 4.0 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 0.4 GO:0050955 thermoception(GO:0050955) detection of temperature stimulus involved in thermoception(GO:0050960) detection of temperature stimulus involved in sensory perception(GO:0050961)
0.1 2.1 GO:0005979 regulation of glycogen biosynthetic process(GO:0005979) regulation of glucan biosynthetic process(GO:0010962)
0.1 3.0 GO:0009648 photoperiodism(GO:0009648)
0.1 0.9 GO:0035677 posterior lateral line neuromast hair cell development(GO:0035677)
0.1 4.0 GO:0007019 microtubule depolymerization(GO:0007019)
0.1 6.4 GO:0014904 myotube cell development(GO:0014904) skeletal muscle fiber development(GO:0048741)
0.1 1.7 GO:0006198 cAMP catabolic process(GO:0006198)
0.1 2.1 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.9 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.1 1.0 GO:0007634 optokinetic behavior(GO:0007634)
0.1 0.3 GO:0060080 inhibitory postsynaptic potential(GO:0060080) regulation of synaptic transmission, glycinergic(GO:0060092)
0.1 1.4 GO:0010257 mitochondrial electron transport, NADH to ubiquinone(GO:0006120) NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1 2.7 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 1.3 GO:0019433 triglyceride catabolic process(GO:0019433)
0.1 1.1 GO:0060078 regulation of postsynaptic membrane potential(GO:0060078)
0.1 1.5 GO:0007020 microtubule nucleation(GO:0007020)
0.1 2.5 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 0.6 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.1 0.6 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.1 2.5 GO:0061386 closure of optic fissure(GO:0061386)
0.1 0.6 GO:0033700 phospholipid efflux(GO:0033700)
0.1 0.6 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.1 3.6 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.1 1.3 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.1 0.4 GO:0048659 smooth muscle cell proliferation(GO:0048659)
0.1 1.0 GO:0097320 membrane tubulation(GO:0097320)
0.1 2.4 GO:0036269 swimming behavior(GO:0036269)
0.1 0.2 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 2.1 GO:0050708 regulation of protein secretion(GO:0050708)
0.1 3.9 GO:0032869 cellular response to insulin stimulus(GO:0032869)
0.1 0.8 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 0.8 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.1 2.0 GO:0055064 chloride ion homeostasis(GO:0055064)
0.1 2.2 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.1 27.1 GO:0043066 negative regulation of apoptotic process(GO:0043066)
0.1 1.9 GO:0003094 glomerular filtration(GO:0003094)
0.1 0.3 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.1 1.1 GO:1990798 pancreas regeneration(GO:1990798)
0.1 4.4 GO:0007605 sensory perception of sound(GO:0007605)
0.1 2.7 GO:1901800 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.1 1.0 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 0.5 GO:0044090 positive regulation of vacuole organization(GO:0044090)
0.1 1.1 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.1 0.3 GO:0044458 motile cilium assembly(GO:0044458)
0.1 0.9 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 1.9 GO:1900449 regulation of glutamate receptor signaling pathway(GO:1900449)
0.0 1.8 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.0 0.5 GO:0022615 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 0.3 GO:0031507 heterochromatin assembly(GO:0031507)
0.0 0.4 GO:0060325 face morphogenesis(GO:0060325)
0.0 1.6 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway(GO:0071880)
0.0 0.7 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.0 1.1 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.0 4.5 GO:0006936 muscle contraction(GO:0006936)
0.0 0.1 GO:0071939 vitamin A transport(GO:0071938) vitamin A import(GO:0071939)
0.0 2.0 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.9 GO:0010883 regulation of lipid storage(GO:0010883)
0.0 1.5 GO:0060536 cartilage morphogenesis(GO:0060536)
0.0 1.3 GO:0045324 late endosome to vacuole transport(GO:0045324)
0.0 0.6 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.5 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.7 GO:0036294 cellular response to decreased oxygen levels(GO:0036294) cellular response to hypoxia(GO:0071456)
0.0 0.6 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 0.7 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 2.0 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 1.9 GO:0030336 negative regulation of cell migration(GO:0030336)
0.0 0.3 GO:2000117 negative regulation of cysteine-type endopeptidase activity(GO:2000117)
0.0 0.4 GO:0030259 lipid glycosylation(GO:0030259)
0.0 3.9 GO:0021782 glial cell development(GO:0021782)
0.0 1.0 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.5 GO:0046051 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.0 0.2 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.0 0.9 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 7.1 GO:0007018 microtubule-based movement(GO:0007018)
0.0 0.2 GO:0006545 glycine biosynthetic process(GO:0006545)
0.0 0.4 GO:0042407 cristae formation(GO:0042407)
0.0 2.2 GO:0070509 calcium ion import(GO:0070509)
0.0 2.5 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.4 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.0 0.9 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 1.3 GO:0015914 phospholipid transport(GO:0015914)
0.0 0.3 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.6 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.0 1.1 GO:0006821 chloride transport(GO:0006821)
0.0 0.2 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.0 0.7 GO:0046058 cAMP metabolic process(GO:0046058)
0.0 0.3 GO:0070828 heterochromatin organization(GO:0070828)
0.0 0.5 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 0.1 GO:0032782 canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782)
0.0 1.0 GO:0030318 melanocyte differentiation(GO:0030318)
0.0 4.6 GO:0006813 potassium ion transport(GO:0006813)
0.0 0.2 GO:0070265 necrotic cell death(GO:0070265) programmed necrotic cell death(GO:0097300)
0.0 0.4 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 0.9 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.4 GO:0033962 cytoplasmic mRNA processing body assembly(GO:0033962)
0.0 0.1 GO:0071156 regulation of cell cycle arrest(GO:0071156)
0.0 0.8 GO:0048484 enteric nervous system development(GO:0048484)
0.0 0.3 GO:0021551 central nervous system morphogenesis(GO:0021551)
0.0 0.1 GO:0090520 sphingolipid mediated signaling pathway(GO:0090520)
0.0 1.9 GO:0010506 regulation of autophagy(GO:0010506)
0.0 2.5 GO:0016042 lipid catabolic process(GO:0016042)
0.0 0.8 GO:0055088 lipid homeostasis(GO:0055088)
0.0 0.8 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 1.4 GO:0008285 negative regulation of cell proliferation(GO:0008285)
0.0 0.4 GO:0072114 pronephros morphogenesis(GO:0072114)
0.0 0.6 GO:0032924 activin receptor signaling pathway(GO:0032924)
0.0 0.9 GO:0009880 embryonic pattern specification(GO:0009880)
0.0 1.2 GO:0048565 digestive tract development(GO:0048565)
0.0 1.5 GO:0030902 hindbrain development(GO:0030902)
0.0 1.8 GO:0070646 protein modification by small protein removal(GO:0070646)
0.0 1.4 GO:0006814 sodium ion transport(GO:0006814)
0.0 0.7 GO:0050772 positive regulation of axonogenesis(GO:0050772)
0.0 0.3 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.5 GO:0031929 TOR signaling(GO:0031929)
0.0 0.3 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.7 GO:0042391 regulation of membrane potential(GO:0042391)
0.0 0.2 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.7 GO:0007224 smoothened signaling pathway(GO:0007224)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 49.3 GO:0005861 troponin complex(GO:0005861)
1.0 7.0 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.8 3.1 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.7 2.2 GO:0042709 succinate-CoA ligase complex(GO:0042709)
0.6 3.6 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.6 5.6 GO:0098982 GABA-ergic synapse(GO:0098982)
0.4 6.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.4 6.3 GO:0005869 dynactin complex(GO:0005869)
0.3 1.0 GO:0033391 chromatoid body(GO:0033391)
0.3 11.3 GO:0043679 axon terminus(GO:0043679)
0.3 3.1 GO:0031045 dense core granule(GO:0031045)
0.3 1.5 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.2 1.9 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.2 0.9 GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex(GO:0008247)
0.2 4.5 GO:0031430 M band(GO:0031430)
0.2 1.1 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.2 1.4 GO:0071818 BAT3 complex(GO:0071818)
0.2 1.6 GO:0045171 intercellular bridge(GO:0045171)
0.1 5.0 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 0.6 GO:0060171 stereocilium membrane(GO:0060171)
0.1 2.5 GO:0030667 secretory granule membrane(GO:0030667)
0.1 1.0 GO:0030897 HOPS complex(GO:0030897)
0.1 0.4 GO:0031417 NatC complex(GO:0031417)
0.1 8.0 GO:0030426 growth cone(GO:0030426)
0.1 3.2 GO:0046930 pore complex(GO:0046930)
0.1 0.6 GO:1990513 CLOCK-BMAL transcription complex(GO:1990513)
0.1 2.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 1.5 GO:0036157 outer dynein arm(GO:0036157)
0.1 1.9 GO:0031209 SCAR complex(GO:0031209)
0.1 2.1 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.1 2.2 GO:0001917 photoreceptor inner segment(GO:0001917)
0.1 1.0 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 4.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 2.0 GO:0097546 ciliary base(GO:0097546)
0.1 1.3 GO:0000815 ESCRT III complex(GO:0000815)
0.1 4.1 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.1 2.0 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 2.9 GO:0030175 filopodium(GO:0030175)
0.1 0.9 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 4.6 GO:0016342 catenin complex(GO:0016342)
0.1 1.5 GO:0031594 neuromuscular junction(GO:0031594)
0.1 1.1 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.1 4.4 GO:0030141 secretory granule(GO:0030141)
0.1 0.6 GO:0038039 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor heterodimeric complex(GO:0038039) G-protein coupled receptor complex(GO:0097648)
0.1 2.2 GO:0035869 ciliary transition zone(GO:0035869)
0.1 4.1 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 0.5 GO:0031931 TORC1 complex(GO:0031931)
0.1 1.4 GO:0045335 phagocytic vesicle(GO:0045335)
0.1 1.0 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 1.3 GO:0044447 axoneme part(GO:0044447)
0.1 3.2 GO:0048786 presynaptic active zone(GO:0048786)
0.1 0.6 GO:0005688 U6 snRNP(GO:0005688)
0.1 0.7 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 4.5 GO:0005871 kinesin complex(GO:0005871)
0.0 0.3 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 2.1 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 3.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.6 GO:0048179 activin receptor complex(GO:0048179)
0.0 1.5 GO:0005902 microvillus(GO:0005902)
0.0 0.3 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.6 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.9 GO:0005844 polysome(GO:0005844)
0.0 0.9 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 3.9 GO:0005882 intermediate filament(GO:0005882)
0.0 0.4 GO:0061617 MICOS complex(GO:0061617)
0.0 2.1 GO:0031201 SNARE complex(GO:0031201)
0.0 10.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.4 GO:0017119 Golgi transport complex(GO:0017119)
0.0 1.1 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.2 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0 0.6 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 3.6 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.2 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 2.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.0 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 0.5 GO:0032039 integrator complex(GO:0032039)
0.0 0.4 GO:0098798 mitochondrial protein complex(GO:0098798)
0.0 0.3 GO:0008328 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 0.3 GO:0038201 TORC2 complex(GO:0031932) TOR complex(GO:0038201)
0.0 1.0 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 9.5 GO:0043005 neuron projection(GO:0043005)
0.0 0.5 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.7 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 2.3 GO:0005874 microtubule(GO:0005874)
0.0 0.4 GO:0031105 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 6.0 GO:0005471 ATP:ADP antiporter activity(GO:0005471)
0.9 3.7 GO:0004807 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
0.9 2.7 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.8 6.8 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.8 2.3 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.7 2.2 GO:0004774 succinate-CoA ligase activity(GO:0004774) succinate-CoA ligase (ADP-forming) activity(GO:0004775) succinate-CoA ligase (GDP-forming) activity(GO:0004776)
0.7 2.2 GO:1990174 phosphodiesterase decapping endonuclease activity(GO:1990174)
0.7 3.6 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.7 2.0 GO:0031716 calcitonin receptor binding(GO:0031716)
0.7 4.6 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.6 3.9 GO:0031705 bombesin receptor binding(GO:0031705)
0.6 3.2 GO:0015288 porin activity(GO:0015288)
0.6 3.6 GO:0004743 pyruvate kinase activity(GO:0004743)
0.5 4.4 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.5 2.7 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.4 7.6 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.4 5.9 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.4 1.3 GO:0004061 arylformamidase activity(GO:0004061)
0.4 2.4 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.4 1.5 GO:0004361 glutaryl-CoA dehydrogenase activity(GO:0004361)
0.3 4.4 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.3 4.0 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.3 2.7 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.3 6.2 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.3 4.4 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.3 5.3 GO:0004383 guanylate cyclase activity(GO:0004383)
0.3 1.9 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.3 1.0 GO:0071253 connexin binding(GO:0071253)
0.2 2.9 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.2 1.4 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.2 2.6 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.2 1.9 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.2 8.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.2 2.4 GO:0015101 organic cation transmembrane transporter activity(GO:0015101)
0.2 2.5 GO:0031628 opioid receptor binding(GO:0031628)
0.2 2.3 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.2 3.2 GO:0005080 protein kinase C binding(GO:0005080)
0.2 1.1 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.2 1.9 GO:0031995 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.2 4.6 GO:0017080 sodium channel regulator activity(GO:0017080)
0.2 2.3 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.2 0.6 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.1 0.9 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.1 1.6 GO:0004568 chitinase activity(GO:0004568)
0.1 5.0 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 2.1 GO:2001069 glycogen binding(GO:2001069)
0.1 0.4 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.1 2.3 GO:0032190 acrosin binding(GO:0032190)
0.1 0.6 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.1 2.8 GO:0016854 racemase and epimerase activity(GO:0016854)
0.1 2.1 GO:0045159 myosin II binding(GO:0045159)
0.1 1.9 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 1.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 0.7 GO:0004104 cholinesterase activity(GO:0004104)
0.1 2.1 GO:0030552 cAMP binding(GO:0030552)
0.1 1.3 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.1 1.4 GO:0008422 beta-glucosidase activity(GO:0008422)
0.1 0.6 GO:0090554 phospholipid-translocating ATPase activity(GO:0004012) phosphatidylcholine-translocating ATPase activity(GO:0090554) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.1 1.5 GO:0045503 dynein light chain binding(GO:0045503)
0.1 4.8 GO:0005548 phospholipid transporter activity(GO:0005548)
0.1 3.1 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 0.5 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.1 1.3 GO:0010851 cyclase regulator activity(GO:0010851)
0.1 0.6 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172)
0.1 1.5 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 1.0 GO:0052812 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.1 3.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 0.6 GO:0070888 E-box binding(GO:0070888)
0.1 2.4 GO:0003954 NADH dehydrogenase activity(GO:0003954)
0.1 4.9 GO:0019905 syntaxin binding(GO:0019905)
0.1 1.8 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 0.9 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 2.1 GO:0022840 leak channel activity(GO:0022840) potassium ion leak channel activity(GO:0022841) narrow pore channel activity(GO:0022842)
0.1 0.2 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.1 0.7 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.1 3.1 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 0.6 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 2.2 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 0.6 GO:0016917 GABA receptor activity(GO:0016917)
0.1 1.6 GO:0017046 peptide hormone binding(GO:0017046)
0.1 0.8 GO:0052794 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.1 3.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 0.7 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 2.1 GO:0017022 myosin binding(GO:0017022)
0.1 1.4 GO:0003785 actin monomer binding(GO:0003785)
0.1 8.2 GO:0003777 microtubule motor activity(GO:0003777)
0.1 1.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 1.1 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.1 1.4 GO:0005523 tropomyosin binding(GO:0005523)
0.1 0.6 GO:0043495 protein anchor(GO:0043495)
0.1 0.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 0.9 GO:0070840 dynein complex binding(GO:0070840)
0.1 1.0 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.5 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 1.4 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 1.6 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 1.1 GO:0015026 coreceptor activity(GO:0015026)
0.1 0.6 GO:0004046 aminoacylase activity(GO:0004046)
0.1 0.9 GO:0042910 xenobiotic transporter activity(GO:0042910)
0.1 0.3 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.1 5.1 GO:0045296 cadherin binding(GO:0045296)
0.1 2.3 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 0.5 GO:0004096 catalase activity(GO:0004096)
0.1 0.6 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.3 GO:0035255 GKAP/Homer scaffold activity(GO:0030160) ionotropic glutamate receptor binding(GO:0035255)
0.0 2.6 GO:0008374 O-acyltransferase activity(GO:0008374)
0.0 0.8 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.0 0.3 GO:0015238 drug transmembrane transporter activity(GO:0015238) azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0 4.6 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 1.4 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.8 GO:0016251 obsolete general RNA polymerase II transcription factor activity(GO:0016251)
0.0 0.6 GO:0017002 activin-activated receptor activity(GO:0017002)
0.0 0.2 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 1.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.5 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 13.0 GO:0051015 actin filament binding(GO:0051015)
0.0 0.3 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.1 GO:0016623 aldehyde oxidase activity(GO:0004031) oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0 0.8 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.3 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 1.3 GO:0071949 FAD binding(GO:0071949)
0.0 0.7 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 1.2 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.5 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 2.3 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 0.1 GO:0015126 canalicular bile acid transmembrane transporter activity(GO:0015126) bile acid-exporting ATPase activity(GO:0015432)
0.0 0.3 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.0 20.6 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 0.2 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.4 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.6 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:0034632 retinol transporter activity(GO:0034632)
0.0 0.2 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 1.5 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.5 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 1.0 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.2 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.6 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 3.9 GO:0015631 tubulin binding(GO:0015631)
0.0 0.5 GO:0005109 frizzled binding(GO:0005109)
0.0 0.3 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.1 GO:0051117 ATPase binding(GO:0051117)
0.0 1.0 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 0.8 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.0 4.7 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 2.1 GO:0042802 identical protein binding(GO:0042802)
0.0 0.3 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.0 0.1 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 1.7 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.4 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.2 0.5 PID CONE PATHWAY Visual signal transduction: Cones
0.2 3.8 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 1.3 PID EPHB FWD PATHWAY EPHB forward signaling
0.1 3.1 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 1.3 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 5.7 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 2.3 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 3.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 0.7 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 1.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.5 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.7 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 4.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.3 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 1.8 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.5 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 1.0 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.4 PID EPHA FWDPATHWAY EPHA forward signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.8 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.3 2.4 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.3 2.7 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.3 1.3 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.2 1.7 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.2 2.6 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 2.3 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.2 9.3 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.2 2.2 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.2 1.7 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 1.6 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 3.6 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.1 0.9 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 8.4 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 2.0 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 1.8 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 1.0 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.1 1.9 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.4 REACTOME FGFR LIGAND BINDING AND ACTIVATION Genes involved in FGFR ligand binding and activation
0.1 0.9 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 1.4 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.7 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 1.7 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.5 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.5 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 0.7 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.3 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 2.1 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.0 0.5 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.6 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 1.7 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.0 0.4 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.4 REACTOME SIGNALING BY FGFR1 MUTANTS Genes involved in Signaling by FGFR1 mutants
0.0 1.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.2 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 1.0 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.8 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes