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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for raraa+rarab

Z-value: 0.28

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Transcription factors associated with raraa+rarab

Gene Symbol Gene ID Gene Info
rarab
ENSDARG00000034893 retinoic acid receptor, alpha b
raraa
ENSDARG00000056783 retinoic acid receptor, alpha a
rarab
ENSDARG00000111757 retinoic acid receptor, alpha b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
raraadr11_v1_chr12_+_10952794_10952794-0.391.2e-04Click!
rarabdr11_v1_chr3_-_33175583_33175583-0.242.2e-02Click!

Activity profile of raraa+rarab motif

Sorted Z-values of raraa+rarab motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr22_+_38173960 3.61 ENSDART00000010537
cp
ceruloplasmin
chr17_+_33340675 2.39 ENSDART00000184396
ENSDART00000077553
xdh
xanthine dehydrogenase
chr4_+_1530287 1.87 ENSDART00000067446
slc38a4
solute carrier family 38, member 4
chr14_-_50892442 1.68 ENSDART00000174562
CDHR2
cadherin related family member 2
chr2_+_52847049 1.42 ENSDART00000121980
creb3l3b
cAMP responsive element binding protein 3-like 3b
chr18_+_7073130 1.32 ENSDART00000101216
ENSDART00000148947
si:dkey-88e18.2
si:dkey-88e18.2
chr5_-_3885727 1.09 ENSDART00000143250
mlxipl
MLX interacting protein like
chr17_+_14886828 1.06 ENSDART00000010507
ENSDART00000131052
ptger2a
prostaglandin E receptor 2a (subtype EP2)
chr16_-_22194400 1.04 ENSDART00000186042
il6r
interleukin 6 receptor
chr3_+_5297493 1.03 ENSDART00000138596
si:ch211-150d5.3
si:ch211-150d5.3
chr10_+_19595009 0.93 ENSDART00000112276
zgc:173837
zgc:173837
chr14_-_36862745 0.86 ENSDART00000109293
rnf130
ring finger protein 130
chr11_-_34147205 0.64 ENSDART00000173216
atp13a3
ATPase 13A3
chr23_+_25305431 0.61 ENSDART00000143291
RPL41
si:dkey-151g10.6
chr19_+_7938121 0.55 ENSDART00000140053
ENSDART00000146649
si:dkey-266f7.5
si:dkey-266f7.5
chr23_+_25822742 0.53 ENSDART00000184436
r3hdml
R3H domain containing-like
chr24_-_36727922 0.50 ENSDART00000135142
si:ch73-334d15.1
si:ch73-334d15.1
chr24_+_37723362 0.48 ENSDART00000136836
rab11fip3
RAB11 family interacting protein 3 (class II)
chr9_+_7068832 0.48 ENSDART00000186685
BX629348.1

chr17_+_46739693 0.36 ENSDART00000097810
pimr22
Pim proto-oncogene, serine/threonine kinase, related 22
chr10_-_41450367 0.32 ENSDART00000122682
ENSDART00000189549
cabp1b
calcium binding protein 1b
chr15_+_31735931 0.31 ENSDART00000185681
ENSDART00000149137
rxfp2b
relaxin/insulin-like family peptide receptor 2b
chr24_+_42149453 0.30 ENSDART00000128766
serpinb1l3
serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 3
chr6_+_103361 0.28 ENSDART00000151899
ldlrb
low density lipoprotein receptor b
chr15_+_47582207 0.28 ENSDART00000159388
CABZ01087566.1

chr14_+_94603 0.27 ENSDART00000162480
mcm7
minichromosome maintenance complex component 7
chr22_-_31788170 0.26 ENSDART00000170925
pimr207
Pim proto-oncogene, serine/threonine kinase, related 207
chr7_-_24838857 0.26 ENSDART00000179766
ENSDART00000180892
fam113
family with sequence similarity 113
chr14_+_94946 0.26 ENSDART00000165766
ENSDART00000163778
mcm7
minichromosome maintenance complex component 7
chr8_-_13471916 0.24 ENSDART00000146558
pimr105
Pim proto-oncogene, serine/threonine kinase, related 105
chr7_-_69352424 0.23 ENSDART00000170714
ap1g1
adaptor-related protein complex 1, gamma 1 subunit
chr22_+_21324398 0.23 ENSDART00000168509
shc2
SHC (Src homology 2 domain containing) transforming protein 2
chr8_-_13419049 0.23 ENSDART00000133656
pimr101
Pim proto-oncogene, serine/threonine kinase, related 101
chr21_+_2506013 0.22 ENSDART00000162351
hmgcrb
3-hydroxy-3-methylglutaryl-CoA reductase b
chr8_-_13428740 0.21 ENSDART00000131826
CR354547.3

chr8_-_10947205 0.21 ENSDART00000164467
pqlc2
PQ loop repeat containing 2
chr14_+_36497250 0.21 ENSDART00000184727
TENM3
si:dkey-237h12.3
chr25_-_3132060 0.19 ENSDART00000014363
epx
eosinophil peroxidase
chr23_-_21758253 0.18 ENSDART00000046613
vps13d
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr24_+_42149296 0.18 ENSDART00000154231
serpinb1l3
serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 3
chr15_+_1199407 0.18 ENSDART00000163827
mfsd1
major facilitator superfamily domain containing 1
chr13_+_28618086 0.16 ENSDART00000087001
cnnm2a
cyclin and CBS domain divalent metal cation transport mediator 2a
chr18_+_19842569 0.15 ENSDART00000147470
iqch
IQ motif containing H
chr8_-_13442871 0.15 ENSDART00000144887
pimr106
Pim proto-oncogene, serine/threonine kinase, related 106
chr12_-_2869565 0.14 ENSDART00000152772
zdhhc16b
zinc finger, DHHC-type containing 16b
chr8_-_13454281 0.13 ENSDART00000141959
CR354547.2

chr18_+_1145571 0.11 ENSDART00000135055
rec114
REC114 meiotic recombination protein
chr9_+_500052 0.11 ENSDART00000166707
CU984600.1

chr5_-_64823750 0.11 ENSDART00000140305
lix1
limb and CNS expressed 1
chr8_-_13486258 0.10 ENSDART00000137459
pimr104
Pim proto-oncogene, serine/threonine kinase, related 104
chr1_+_57348756 0.08 ENSDART00000063750
b3gntl1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
chr1_+_59538755 0.08 ENSDART00000166354
sp6
Sp6 transcription factor
chr14_+_41518257 0.08 ENSDART00000050037
chrnb3b
cholinergic receptor, nicotinic, beta 3b (neuronal)
chr18_-_36066087 0.08 ENSDART00000059352
ENSDART00000145177
exosc5
exosome component 5
chr5_+_64856666 0.04 ENSDART00000050863
zgc:101858
zgc:101858
chr18_+_3338228 0.04 ENSDART00000161520
gdpd4a
glycerophosphodiester phosphodiesterase domain containing 4a
chr12_-_34427909 0.03 ENSDART00000129501
tmem235
transmembrane protein 235
chr11_+_1608348 0.01 ENSDART00000162438
si:dkey-40c23.3
si:dkey-40c23.3

Network of associatons between targets according to the STRING database.

First level regulatory network of raraa+rarab

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0006145 purine nucleobase catabolic process(GO:0006145)
0.2 1.1 GO:0071380 response to prostaglandin E(GO:0034695) cellular response to prostaglandin E stimulus(GO:0071380)
0.2 3.6 GO:0006825 copper ion transport(GO:0006825)
0.0 0.5 GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.0 0.2 GO:0001955 blood vessel maturation(GO:0001955)
0.0 1.9 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 1.4 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.0 0.2 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.0 0.3 GO:0045762 activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762)
0.0 0.2 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.0 0.1 GO:0071051 polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.0 0.5 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.2 GO:0006896 Golgi to vacuole transport(GO:0006896)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.5 GO:0042555 MCM complex(GO:0042555)
0.0 2.6 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.5 GO:0097610 cleavage furrow(GO:0032154) recycling endosome membrane(GO:0055038) cell surface furrow(GO:0097610)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.4 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups(GO:0016725)
0.2 3.6 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 1.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.1 0.5 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140) single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity(GO:1990518)
0.1 1.4 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.5 GO:0031267 small GTPase binding(GO:0031267)
0.0 1.9 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 0.2 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 3.6 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 0.5 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.2 PID VEGFR1 PATHWAY VEGFR1 specific signals

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.4 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.2 3.6 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.1 1.0 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 1.9 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.5 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.2 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.2 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 1.1 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism