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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for roraa+rorab

Z-value: 0.91

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Transcription factors associated with roraa+rorab

Gene Symbol Gene ID Gene Info
ENSDARG00000001910 RAR-related orphan receptor A, paralog b
ENSDARG00000031768 RAR-related orphan receptor A, paralog a
ENSDARG00000109324 RAR-related orphan receptor A, paralog b
ENSDARG00000113275 RAR-related orphan receptor A, paralog b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
roraadr11_v1_chr25_+_33939728_339397280.716.8e-16Click!
rorabdr11_v1_chr7_-_29571615_295716150.494.0e-07Click!

Activity profile of roraa+rorab motif

Sorted Z-values of roraa+rorab motif

Promoter Log-likelihood Transcript Gene Gene Info
chr25_-_19374710 15.32 ENSDART00000184483
ENSDART00000188706
microtubule-associated protein 1Ab
chr4_+_2620751 12.78 ENSDART00000013924
G protein-coupled receptor 22a
chr7_+_29133321 10.53 ENSDART00000052346
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b
chr14_-_33454595 9.77 ENSDART00000109615
ENSDART00000173267
ENSDART00000185737
ENSDART00000190989
transmembrane protein 255A
chr23_+_44741500 9.68 ENSDART00000166421
ATPase Na+/K+ transporting subunit beta 2a
chr1_-_50859053 9.57 ENSDART00000132779
ENSDART00000137648
si:dkeyp-123h10.2
chr19_+_30662529 9.20 ENSDART00000175662
family with sequence similarity 49, member A-like
chr7_+_40228422 9.11 ENSDART00000052222
protein tyrosine phosphatase, receptor type, N polypeptide 2
chr5_-_55395964 8.99 ENSDART00000145791
prune homolog 2 (Drosophila)
chr23_+_19564392 8.96 ENSDART00000144746
ATPase H+ transporting accessory protein 1 like b
chr23_-_19953089 8.86 ENSDART00000153828
ATPase plasma membrane Ca2+ transporting 3b
chr13_-_31452516 8.81 ENSDART00000193268
reticulon 1a
chr10_+_20128267 8.10 ENSDART00000064615
dematin actin binding protein
chr19_-_5103313 8.04 ENSDART00000037007
triosephosphate isomerase 1a
chr2_+_34767171 8.01 ENSDART00000145451
astrotactin 1
chr16_+_5678071 7.86 ENSDART00000011166
ENSDART00000134198
ENSDART00000131575
zgc:158689
chr10_+_17850934 7.81 ENSDART00000113666
ENSDART00000145936
PHD finger protein 24
chr3_-_19091024 7.66 ENSDART00000188485
ENSDART00000110554
glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca
chr10_+_23060391 7.55 ENSDART00000079711
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1a
chr2_-_16380283 7.45 ENSDART00000149992
si:dkey-231j24.3
chr16_-_28856112 7.34 ENSDART00000078543
synaptotagmin XIb
chr20_+_5564042 7.22 ENSDART00000090934
ENSDART00000127050
neurexin 3b
chr4_-_1360495 7.19 ENSDART00000164623
pleiotrophin
chr17_+_15534815 7.09 ENSDART00000159426
myristoylated alanine-rich protein kinase C substrate b
chr10_-_17103651 7.09 ENSDART00000108959
ring finger protein 208
chr19_-_5103141 6.95 ENSDART00000150952
triosephosphate isomerase 1a
chr17_-_7371564 6.85 ENSDART00000060336
RAB32b, member RAS oncogene family
chr18_-_1185772 6.63 ENSDART00000143245
neuroplastin b
chr14_-_31465905 6.57 ENSDART00000173108
glypican 3
chr8_+_14792830 6.52 ENSDART00000139972
calcium channel, voltage-dependent, R type, alpha 1E subunit a
chr20_-_25709247 6.48 ENSDART00000146711
si:dkeyp-117h8.2
chr13_-_29406534 6.30 ENSDART00000100877
zgc:153142
chr1_-_44704261 6.02 ENSDART00000133210
si:dkey-28b4.8
chr7_-_48805181 5.80 ENSDART00000015884
milk fat globule-EGF factor 8 protein a
chr19_-_5805923 5.73 ENSDART00000134340
si:ch211-264f5.8
chr22_-_11124419 5.72 ENSDART00000149634
ATPase H+ transporting accessory protein 2
chr6_-_49159207 5.68 ENSDART00000041942
tetraspanin 2a
chr17_+_15535501 5.64 ENSDART00000002932
myristoylated alanine-rich protein kinase C substrate b
chr11_-_29650930 5.50 ENSDART00000166969
chromodomain helicase DNA binding protein 5
chr6_+_40523370 5.19 ENSDART00000033819
protein kinase C, delta a
chr5_+_20693724 5.07 ENSDART00000141368
si:ch211-240b21.2
chr7_+_50109239 5.06 ENSDART00000021605
si:dkey-6l15.1
chr4_-_17629444 5.02 ENSDART00000108814
nuclear receptor interacting protein 2
chr19_-_32487469 4.95 ENSDART00000050130
guanosine monophosphate reductase
chr10_+_1638876 4.77 ENSDART00000184484
ENSDART00000060946
ENSDART00000181251
small G protein signaling modulator 1b
chr7_+_67494107 4.65 ENSDART00000185653
copine VII
chr1_+_9708801 4.64 ENSDART00000189621
extracellular leucine-rich repeat and fibronectin type III domain containing 1b
chr18_-_42313798 4.56 ENSDART00000098639
contactin 5
chr11_+_28476298 4.36 ENSDART00000122319
leucine rich repeat containing 38b
chr16_-_23885482 4.34 ENSDART00000132243
oxidative stress induced growth inhibitor family member 2
chr17_+_22381215 4.24 ENSDART00000162670
ENSDART00000128875
solute carrier family 8 (sodium/calcium exchanger), member 1b
chr3_-_26191960 4.21 ENSDART00000113843
yippee-like 3
chr6_-_10320676 4.17 ENSDART00000151247
sodium channel, voltage-gated, type I like, alpha b
chr13_-_22907260 3.92 ENSDART00000143097
RUN and FYVE domain containing 2
chr1_+_31725154 3.83 ENSDART00000112333
ENSDART00000189801
cyclin and CBS domain divalent metal cation transport mediator 2b
chr18_-_29962234 3.82 ENSDART00000144996
si:ch73-103b9.2
chr20_+_16750177 3.69 ENSDART00000185357
calmodulin 1b
chr17_+_25290136 3.68 ENSDART00000173295
kelch repeat and BTB (POZ) domain containing 11
chr7_+_44484853 3.66 ENSDART00000189079
ENSDART00000121826
brain expressed, associated with NEDD4, 1
chr18_-_14922872 3.65 ENSDART00000091722
pannexin 2
chr22_+_18816662 3.49 ENSDART00000132476
calcium channel, voltage-dependent, beta subunit associated regulatory protein b
chr2_-_4797512 3.48 ENSDART00000160765
tyrosine kinase, non-receptor, 2b
chr11_+_30729745 3.45 ENSDART00000103270
solute carrier family 22 (organic anion transporter), member 7a
chr1_-_23110740 3.41 ENSDART00000171848
ENSDART00000086797
ENSDART00000189344
ENSDART00000190858
adhesion G protein-coupled receptor L3.1
chr14_-_30490465 3.40 ENSDART00000173107
mitochondrial calcium uptake family, member 3b
chr1_+_12763920 3.29 ENSDART00000189465
protocadherin 10a
chr19_+_19976990 3.27 ENSDART00000052627
neuropeptide VF precursor
chr1_+_23783349 3.27 ENSDART00000007531
slit homolog 2 (Drosophila)
chr12_+_28799988 3.19 ENSDART00000022724
pyridoxamine 5'-phosphate oxidase
chr15_-_11341635 3.19 ENSDART00000055220
RAB30, member RAS oncogene family
chr1_+_54115839 3.17 ENSDART00000180214

chr18_+_16330025 3.16 ENSDART00000142353
neurotensin
chr14_+_2095394 3.10 ENSDART00000186847

chr24_+_29449690 3.04 ENSDART00000105743
ENSDART00000193556
ENSDART00000145816
netrin g1a
chr9_-_30808073 3.04 ENSDART00000146300
Kruppel-like factor 5b
chr3_+_13637383 3.03 ENSDART00000166000
si:ch211-194b1.1
chr3_-_60142530 3.01 ENSDART00000153247
si:ch211-120g10.1
chr18_+_14529005 2.98 ENSDART00000186379
potassium voltage-gated channel, subfamily G, member 4a
chr2_+_30787128 2.92 ENSDART00000189233
ATPase H+ transporting V1 subunit H
chr3_+_24060454 2.83 ENSDART00000143088
chromobox homolog 1a (HP1 beta homolog Drosophila)
chr3_+_32698424 2.83 ENSDART00000055340
FUS RNA binding protein
chr5_+_1219187 2.81 ENSDART00000129490
expressed sequence BC139872
chr6_+_3710865 2.80 ENSDART00000170781
phosphatase, orphan 2
chr10_+_20113830 2.79 ENSDART00000139722
dematin actin binding protein
chr24_-_10919588 2.79 ENSDART00000131204
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1b
chr6_-_15603675 2.69 ENSDART00000143502
leucine rich repeat (in FLII) interacting protein 1b
chr9_+_4306122 2.68 ENSDART00000193722
ENSDART00000190521
kalirin RhoGEF kinase a
chr18_-_42333428 2.65 ENSDART00000034225
contactin 5
chr22_+_30184039 2.63 ENSDART00000049075
adducin 3 (gamma) a
chr22_-_17574511 2.61 ENSDART00000181496
phosphatidylinositol-4-phosphate 5-kinase, type I, gamma a
chr23_-_15284757 2.57 ENSDART00000139135
sulfatase 2b
chr17_+_23964132 2.52 ENSDART00000154823
exportin 1 (CRM1 homolog, yeast) b
chr13_+_15800742 2.52 ENSDART00000146234
apoptogenic 1, mitochondrial
chr9_+_17982737 2.48 ENSDART00000192569
A kinase (PRKA) anchor protein 11
chr20_-_14680897 2.43 ENSDART00000063857
ENSDART00000161314
secernin 2
chr9_-_16877456 2.39 ENSDART00000161105
ENSDART00000160869
F-box and leucine-rich repeat protein 3a
chr8_-_9570511 2.25 ENSDART00000044000
plexin A3
chr5_+_31860043 2.25 ENSDART00000036235
ENSDART00000140541
iron-sulfur cluster assembly enzyme b
chr7_+_48805534 2.23 ENSDART00000145375
ENSDART00000148744
carnitine palmitoyltransferase 1Aa (liver)
chr17_-_7818944 2.21 ENSDART00000135538
ENSDART00000037541
required for meiotic nuclear division 1 homolog
chr15_+_5116179 2.19 ENSDART00000101937
phosphoglucomutase 2-like 1
chr6_+_45692026 2.17 ENSDART00000164759
contactin 4
chr3_+_24062748 2.16 ENSDART00000188574
chromobox homolog 1a (HP1 beta homolog Drosophila)
chr8_+_43016714 2.13 ENSDART00000142671
Ras association (RalGDS/AF-6) domain family member 2a
chr9_-_29844596 2.13 ENSDART00000138574
interleukin 1 receptor accessory protein-like 1a
chr15_+_1705167 2.13 ENSDART00000081940
otolin 1b
chr11_+_5842632 2.07 ENSDART00000111374
ENSDART00000158599
NADH dehydrogenase (ubiquinone) Fe-S protein 7, (NADH-coenzyme Q reductase)
chr10_-_25561751 2.01 ENSDART00000147089
glutamate receptor, ionotropic, kainate 1a
chr17_-_8673278 2.00 ENSDART00000171850
ENSDART00000017337
ENSDART00000148504
ENSDART00000148808
C-terminal binding protein 2a
chr17_-_8673567 1.99 ENSDART00000192714
ENSDART00000012546
C-terminal binding protein 2a
chr17_-_45254585 1.97 ENSDART00000185507
ENSDART00000172080
tau tubulin kinase 2a
chr21_+_39432248 1.96 ENSDART00000179938
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1b
chr6_+_51773873 1.95 ENSDART00000156516
transmembrane protein 74B
chr7_-_30227878 1.94 ENSDART00000173514
zinc finger protein 710b
chr5_-_8636168 1.94 ENSDART00000134877
FYN binding protein a
chr18_+_18000887 1.82 ENSDART00000147797
si:ch211-212o1.2
chrM_+_3803 1.78 ENSDART00000093596
NADH dehydrogenase 1, mitochondrial
chr14_-_29859067 1.77 ENSDART00000136380
sorbin and SH3 domain containing 2b
chr7_-_4036184 1.76 ENSDART00000019949
NDRG family member 2
chr4_+_20954929 1.73 ENSDART00000143674
neuron navigator 3
chr6_-_11523987 1.70 ENSDART00000189363
GULP, engulfment adaptor PTB domain containing 1b
chr1_+_44826367 1.67 ENSDART00000146962
zgc:165520
chr10_+_17592273 1.63 ENSDART00000141221
si:dkey-76p7.5
chr8_+_22478090 1.61 ENSDART00000170263
si:ch211-261n11.7
chr6_-_12788539 1.59 ENSDART00000156415
dedicator of cytokinesis 9b
chr1_+_39859782 1.55 ENSDART00000149984
interferon regulatory factor 2a
chr14_+_9583588 1.54 ENSDART00000164101
transmembrane protein 129, E3 ubiquitin protein ligase
chr9_-_43213229 1.54 ENSDART00000139775
SEC14 and spectrin domains 1
chr3_-_42016693 1.53 ENSDART00000184741
tweety family member 3a
chr5_-_35456269 1.52 ENSDART00000051312
tetratricopeptide repeat domain 33
chr25_-_1235457 1.51 ENSDART00000093093
coronin, actin binding protein, 2Bb
chr19_+_20724347 1.50 ENSDART00000090757
K(lysine) acetyltransferase 2B
chr7_-_56180680 1.50 ENSDART00000098438
spastic paraplegia 7
chr21_+_15709061 1.49 ENSDART00000065772
D-dopachrome tautomerase
chr13_-_18195942 1.46 ENSDART00000079902
solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16
chr3_-_45250924 1.44 ENSDART00000109017
ubiquitin specific peptidase 31
chr8_+_51084993 1.44 ENSDART00000127709
ENSDART00000053768
si:dkey-32e23.6
chr22_-_834106 1.42 ENSDART00000105873
cryptochrome circadian clock 4
chr6_+_30689239 1.41 ENSDART00000065206
WD repeat domain 78
chr9_+_23224761 1.40 ENSDART00000142008
mitogen-activated protein kinase kinase kinase 19
chr15_-_30450898 1.38 ENSDART00000156584
musashi RNA-binding protein 2b
chr9_-_30502010 1.37 ENSDART00000149483
si:dkey-229b18.3
chr13_+_31172833 1.36 ENSDART00000176378

chr16_+_21242491 1.33 ENSDART00000145886
oxysterol binding protein-like 3b
chr15_-_6966221 1.31 ENSDART00000165487
ENSDART00000027657
mitochondrial ribosomal protein S22
chr3_-_25148047 1.31 ENSDART00000089325
mitochondrial elongation factor 1
chr22_+_29135846 1.28 ENSDART00000143811
BAI1-associated protein 2-like 2b
chr12_+_17439580 1.27 ENSDART00000189257
ATPase family, AAA domain containing 1b
chr6_+_8339298 1.27 ENSDART00000151672
si:ch211-276a17.5
chr6_-_45995401 1.26 ENSDART00000154392
carbonic anhydrase XVI b
chr16_-_35427060 1.24 ENSDART00000172294
CTP synthase 1b
chr1_+_27977297 1.21 ENSDART00000180692
ENSDART00000166819
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
chr25_-_21156678 1.20 ENSDART00000156257
WNK lysine deficient protein kinase 1a
chr8_+_25902170 1.19 ENSDART00000193130
ras homolog gene family, member Ab
chr15_-_25304710 1.19 ENSDART00000190690
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1a
chr2_-_22659450 1.15 ENSDART00000115025
THAP domain containing 4
chr3_-_15889508 1.15 ENSDART00000148363
cramped chromatin regulator homolog 1
chr7_+_40083601 1.14 ENSDART00000099046
zgc:112356
chr25_+_34749812 1.14 ENSDART00000185712
WW domain containing E3 ubiquitin protein ligase 2
chr10_-_26273629 1.13 ENSDART00000147790
dachsous cadherin-related 1b
chr5_-_29780752 1.12 ENSDART00000137400
ENSDART00000145021
cilia and flagella associated protein 77
chr11_+_24900123 1.11 ENSDART00000044987
ENSDART00000148023
translocase of inner mitochondrial membrane 17 homolog A (yeast)
chr22_+_11153590 1.08 ENSDART00000188207
BCL6 corepressor
chr23_+_41831224 1.03 ENSDART00000171885
sterol carrier protein 2b
chr22_-_12626105 1.02 ENSDART00000115344
ENSDART00000193390
ENSDART00000183949
centrosomal protein 70
chr9_-_43213057 1.02 ENSDART00000059448
ENSDART00000133589
SEC14 and spectrin domains 1
chr2_-_8688759 1.01 ENSDART00000010257
mitoguardin 1
chr19_+_43669122 1.00 ENSDART00000139151
si:ch211-193k19.1
chr15_-_14486534 0.97 ENSDART00000179368
numb homolog (Drosophila)-like
chr7_+_13491452 0.96 ENSDART00000053535
ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 like
chr1_+_54901028 0.96 ENSDART00000137352
zinc finger, FYVE domain containing 27
chr11_+_7432533 0.95 ENSDART00000180977
adhesion G protein-coupled receptor L2a
chr7_+_48805725 0.95 ENSDART00000166543
carnitine palmitoyltransferase 1Aa (liver)
chr14_+_48045193 0.94 ENSDART00000124773
peptidylprolyl isomerase D
chr23_-_24488696 0.90 ENSDART00000155593
transmembrane protein 82
chr8_+_22477922 0.90 ENSDART00000189766
ENSDART00000179717
si:ch211-261n11.7
chr3_+_15360879 0.88 ENSDART00000083976
SH2B adaptor protein 1
chr8_+_2530065 0.88 ENSDART00000063943
mitochondrial ribosomal protein L40
chr10_-_7988396 0.83 ENSDART00000141445
ENSDART00000024282
EWS RNA-binding protein 1a
chr17_-_36513936 0.76 ENSDART00000165075
si:dkey-25g12.4
chr5_+_30998764 0.76 ENSDART00000185783
ENSDART00000147874
ankyrin repeat and FYVE domain containing 1
chr11_+_24819324 0.74 ENSDART00000184549
lysine (K)-specific demethylase 5Ba
chr4_+_18963822 0.73 ENSDART00000066975
ENSDART00000066973
IMP (inosine 5'-monophosphate) dehydrogenase 1b
chr14_-_29858883 0.73 ENSDART00000141034
sorbin and SH3 domain containing 2b
chr8_+_8012570 0.70 ENSDART00000183429
si:ch211-169p10.1
chr23_-_5683147 0.65 ENSDART00000102766
ENSDART00000067351
troponin T type 2a (cardiac)
chr5_+_43470544 0.65 ENSDART00000111587
Rho-related BTB domain containing 2a
chr22_+_18156000 0.65 ENSDART00000143483
ENSDART00000136133
nuclear receptor 2C2-associated protein
chr21_+_7582036 0.64 ENSDART00000135485
ENSDART00000027268
orthopedia homeobox a
chr9_-_1986014 0.62 ENSDART00000142842
homeobox D12a
chr7_+_40884012 0.58 ENSDART00000149395
sonic hedgehog a
chr18_+_9382847 0.58 ENSDART00000061886
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ab
chr8_+_25893071 0.58 ENSDART00000078161
transmembrane protein 115
chr12_+_46708920 0.57 ENSDART00000153089
exocyst complex component 7
chr5_+_36870737 0.56 ENSDART00000145182
solute carrier family 8 (sodium/calcium exchanger), member 2a
chr11_+_24819624 0.56 ENSDART00000155514
lysine (K)-specific demethylase 5Ba
chr7_+_22313533 0.55 ENSDART00000123457
si:dkey-11f12.2
chr8_+_42917515 0.50 ENSDART00000021715
solute carrier family 23 (ascorbic acid transporter), member 2
chr17_+_23554932 0.45 ENSDART00000135814
pantothenate kinase 1a
chr8_+_21225064 0.44 ENSDART00000129210
cryptochrome circadian clock 1ba

Network of associatons between targets according to the STRING database.

First level regulatory network of roraa+rorab

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 15.1 GO:0019242 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
1.9 7.5 GO:0006843 mitochondrial citrate transport(GO:0006843)
1.4 4.2 GO:1904059 regulation of locomotor rhythm(GO:1904059)
1.1 3.3 GO:0007414 axonal defasciculation(GO:0007414)
1.1 3.2 GO:0046184 aldehyde biosynthetic process(GO:0046184)
1.1 12.7 GO:0050714 positive regulation of protein secretion(GO:0050714)
1.0 9.1 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.8 6.6 GO:0060976 coronary vasculature development(GO:0060976)
0.8 3.3 GO:0045938 regulation of endocrine process(GO:0044060) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) endocrine hormone secretion(GO:0060986)
0.8 9.0 GO:0006798 polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.8 3.2 GO:0051012 microtubule sliding(GO:0051012)
0.6 15.3 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.6 4.0 GO:0070073 clustering of voltage-gated calcium channels(GO:0070073)
0.6 2.2 GO:0070131 regulation of mitochondrial translation(GO:0070129) positive regulation of mitochondrial translation(GO:0070131)
0.5 3.7 GO:0032732 positive regulation of interleukin-1 production(GO:0032732)
0.5 2.1 GO:0015988 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) electron transport coupled proton transport(GO:0015990)
0.5 9.7 GO:0071436 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.5 1.5 GO:0090069 regulation of ribosome biogenesis(GO:0090069)
0.5 3.5 GO:0045955 negative regulation of calcium ion-dependent exocytosis(GO:0045955) negative regulation of regulated secretory pathway(GO:1903306)
0.5 12.8 GO:0071910 determination of liver left/right asymmetry(GO:0071910)
0.5 2.8 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.5 10.9 GO:0030032 lamellipodium assembly(GO:0030032)
0.4 8.0 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.4 1.3 GO:0090141 positive regulation of mitochondrial fission(GO:0090141)
0.4 2.9 GO:0048069 eye pigmentation(GO:0048069)
0.4 7.7 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.4 1.1 GO:1903673 mitotic cytokinetic process(GO:1902410) mitotic cleavage furrow formation(GO:1903673)
0.4 6.9 GO:0032438 melanosome organization(GO:0032438)
0.4 2.1 GO:0038065 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.3 3.2 GO:0031998 regulation of fatty acid beta-oxidation(GO:0031998)
0.3 1.2 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.3 2.5 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.2 6.6 GO:0070593 dendrite self-avoidance(GO:0070593)
0.2 4.8 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.2 2.1 GO:0045920 negative regulation of exocytosis(GO:0045920)
0.2 7.3 GO:0014059 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.2 9.8 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.2 0.8 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.2 1.0 GO:0032370 positive regulation of lipid transport(GO:0032370)
0.2 3.4 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.2 2.6 GO:0035860 esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.2 3.3 GO:0097324 melanocyte migration(GO:0097324)
0.2 3.8 GO:0009649 entrainment of circadian clock(GO:0009649) entrainment of circadian clock by photoperiod(GO:0043153)
0.2 4.7 GO:0071277 cellular response to calcium ion(GO:0071277)
0.2 1.2 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.2 0.5 GO:0015882 L-ascorbic acid transport(GO:0015882) L-ascorbic acid metabolic process(GO:0019852)
0.2 0.7 GO:0003228 atrial cardiac muscle tissue development(GO:0003228)
0.2 1.0 GO:0048011 neurotrophin TRK receptor signaling pathway(GO:0048011)
0.2 2.5 GO:0008053 mitochondrial fusion(GO:0008053)
0.1 0.6 GO:0048618 post-embryonic foregut morphogenesis(GO:0048618)
0.1 9.0 GO:0030641 regulation of cellular pH(GO:0030641)
0.1 0.6 GO:0035176 social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
0.1 2.1 GO:1901222 regulation of NIK/NF-kappaB signaling(GO:1901222)
0.1 1.7 GO:0072576 liver morphogenesis(GO:0072576)
0.1 5.8 GO:0007338 single fertilization(GO:0007338)
0.1 7.2 GO:0051781 positive regulation of cell division(GO:0051781)
0.1 3.0 GO:0070831 basement membrane assembly(GO:0070831)
0.1 21.4 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.1 7.6 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)
0.1 2.2 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 3.2 GO:0032482 Rab protein signal transduction(GO:0032482)
0.1 5.5 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.1 1.4 GO:0021772 olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988)
0.1 1.1 GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902254)
0.1 1.2 GO:1902307 positive regulation of sodium ion transport(GO:0010765) positive regulation of sodium ion transmembrane transport(GO:1902307) regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288) positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.1 0.7 GO:0046037 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.1 1.7 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.1 3.4 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.1 2.6 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.1 1.1 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 8.7 GO:0030833 regulation of actin filament polymerization(GO:0030833)
0.0 1.0 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 3.4 GO:0030308 negative regulation of cell growth(GO:0030308)
0.0 0.4 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 1.2 GO:0050821 protein stabilization(GO:0050821)
0.0 4.2 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.5 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 1.0 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.0 1.5 GO:0006821 chloride transport(GO:0006821)
0.0 1.1 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.0 0.9 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 2.7 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 2.8 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 3.0 GO:0051260 protein homooligomerization(GO:0051260)
0.0 2.2 GO:0048675 axon extension(GO:0048675)
0.0 1.5 GO:0006986 response to unfolded protein(GO:0006986)
0.0 6.5 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 0.3 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.0 0.2 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 0.7 GO:0043652 engulfment of apoptotic cell(GO:0043652)
0.0 7.2 GO:0001525 angiogenesis(GO:0001525)
0.0 0.4 GO:0007007 inner mitochondrial membrane organization(GO:0007007)
0.0 1.3 GO:0006338 chromatin remodeling(GO:0006338)
0.0 9.0 GO:0007420 brain development(GO:0007420)
0.0 2.6 GO:0046488 phosphatidylinositol metabolic process(GO:0046488)
0.0 1.9 GO:0072659 protein localization to plasma membrane(GO:0072659) protein localization to cell periphery(GO:1990778)
0.0 2.7 GO:0098656 anion transmembrane transport(GO:0098656)
0.0 0.6 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.4 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.9 GO:1902560 GMP reductase complex(GO:1902560)
1.5 9.0 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
1.0 9.7 GO:0090533 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.8 3.2 GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex(GO:0008247)
0.6 5.2 GO:0001772 immunological synapse(GO:0001772)
0.5 7.7 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.4 2.9 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.4 5.7 GO:0032591 dendritic spine membrane(GO:0032591)
0.4 2.1 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.3 1.2 GO:0097268 cytoophidium(GO:0097268)
0.3 6.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.3 3.4 GO:1990246 uniplex complex(GO:1990246)
0.2 1.0 GO:0032584 growth cone membrane(GO:0032584)
0.2 12.7 GO:0032432 actin filament bundle(GO:0032432)
0.2 7.2 GO:0031225 anchored component of membrane(GO:0031225)
0.2 4.4 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.2 4.2 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.2 6.9 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 3.7 GO:0005921 gap junction(GO:0005921)
0.1 3.0 GO:0043256 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.1 12.1 GO:0030141 secretory granule(GO:0030141)
0.1 8.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 7.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1 15.3 GO:0043025 neuronal cell body(GO:0043025)
0.1 2.3 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 0.3 GO:0030062 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.1 6.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 1.1 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.1 1.7 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 20.4 GO:0030424 axon(GO:0030424)
0.1 1.6 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 1.5 GO:0034707 chloride channel complex(GO:0034707)
0.1 3.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 2.0 GO:0035869 ciliary transition zone(GO:0035869)
0.1 1.2 GO:0043197 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 1.4 GO:0005844 polysome(GO:0005844)
0.0 9.0 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 0.4 GO:0005688 U6 snRNP(GO:0005688)
0.0 2.5 GO:0005925 focal adhesion(GO:0005925)
0.0 0.4 GO:0061617 MICOS complex(GO:0061617)
0.0 2.6 GO:0014069 postsynaptic density(GO:0014069)
0.0 5.8 GO:0098791 Golgi subcompartment(GO:0098791)
0.0 1.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.1 GO:0016342 catenin complex(GO:0016342)
0.0 0.6 GO:0000145 exocyst(GO:0000145)
0.0 0.9 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.2 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 8.4 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 8.0 GO:0005768 endosome(GO:0005768)
0.0 0.3 GO:0034399 nuclear periphery(GO:0034399)
0.0 17.8 GO:0005887 integral component of plasma membrane(GO:0005887)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 15.1 GO:0004807 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
2.0 9.8 GO:0031852 mu-type opioid receptor binding(GO:0031852) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
1.6 4.9 GO:0003920 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.8 9.0 GO:0004309 exopolyphosphatase activity(GO:0004309)
0.7 2.1 GO:0050135 NAD(P)+ nucleosidase activity(GO:0050135)
0.5 14.9 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.5 2.4 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
0.5 9.7 GO:0001671 ATPase activator activity(GO:0001671)
0.4 7.7 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.4 4.8 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.3 1.0 GO:0043621 protein self-association(GO:0043621)
0.3 1.2 GO:0003883 CTP synthase activity(GO:0003883)
0.3 9.7 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.3 5.0 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.3 2.5 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.2 7.7 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.2 3.2 GO:0070840 dynein complex binding(GO:0070840)
0.2 3.3 GO:0048495 Roundabout binding(GO:0048495)
0.2 5.2 GO:0004697 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.2 3.8 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.2 1.5 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.2 1.1 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.2 2.2 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.2 3.9 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 4.2 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.2 1.5 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.2 1.5 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.2 7.3 GO:0001786 phosphatidylserine binding(GO:0001786)
0.2 3.2 GO:0010181 FMN binding(GO:0010181)
0.2 2.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.9 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 3.7 GO:0022829 wide pore channel activity(GO:0022829)
0.1 7.8 GO:0044325 ion channel binding(GO:0044325)
0.1 1.3 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.1 0.7 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 2.9 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 2.3 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 3.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 6.5 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 3.5 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 7.2 GO:0008201 heparin binding(GO:0008201)
0.1 3.2 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 12.7 GO:0005516 calmodulin binding(GO:0005516)
0.1 2.5 GO:0051018 protein kinase A binding(GO:0051018)
0.1 1.2 GO:0019869 chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870)
0.1 0.5 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 2.6 GO:0016307 phosphatidylinositol phosphate kinase activity(GO:0016307)
0.1 2.2 GO:0008198 ferrous iron binding(GO:0008198)
0.1 4.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 0.6 GO:0005113 patched binding(GO:0005113)
0.1 1.0 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 12.7 GO:0042277 peptide binding(GO:0042277)
0.1 0.7 GO:0030172 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.1 4.0 GO:0051287 NAD binding(GO:0051287)
0.0 1.3 GO:0015248 sterol transporter activity(GO:0015248)
0.0 3.9 GO:0003678 DNA helicase activity(GO:0003678)
0.0 30.8 GO:0003779 actin binding(GO:0003779)
0.0 8.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.6 GO:0038191 neuropilin binding(GO:0038191)
0.0 1.5 GO:0005347 ATP transmembrane transporter activity(GO:0005347)
0.0 1.4 GO:0009881 photoreceptor activity(GO:0009881)
0.0 0.3 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.0 0.3 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 7.0 GO:0005096 GTPase activator activity(GO:0005096)
0.0 7.0 GO:0003924 GTPase activity(GO:0003924)
0.0 4.3 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 1.1 GO:0045296 cadherin binding(GO:0045296)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.2 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.2 5.7 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 3.3 PID GLYPICAN 1PATHWAY Glypican 1 network
0.1 1.5 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.1 3.2 PID AP1 PATHWAY AP-1 transcription factor network
0.0 1.8 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.1 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.3 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.9 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.9 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.6 PID INSULIN PATHWAY Insulin Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.9 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.4 6.6 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.3 2.9 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.3 2.3 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.2 3.3 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 1.5 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 1.5 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 3.7 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 0.9 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.1 0.9 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 3.2 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 2.8 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 1.1 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.0 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 4.0 REACTOME NEURONAL SYSTEM Genes involved in Neuronal System
0.0 0.3 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism