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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for rreb1a+rreb1b

Z-value: 2.60

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Transcription factors associated with rreb1a+rreb1b

Gene Symbol Gene ID Gene Info
ENSDARG00000042652 ras responsive element binding protein 1b
ENSDARG00000063701 ras responsive element binding protein 1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
rreb1adr11_v1_chr24_-_2381143_23811430.286.0e-03Click!
rreb1bdr11_v1_chr2_+_21000334_210003550.151.4e-01Click!

Activity profile of rreb1a+rreb1b motif

Sorted Z-values of rreb1a+rreb1b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_10606 48.09 ENSDART00000192650
ENSDART00000186761

chr5_+_817016 45.01 ENSDART00000188498

chr5_+_828663 45.00 ENSDART00000181776

chr4_-_77563411 33.41 ENSDART00000186841

chr21_+_28445052 32.59 ENSDART00000077871
phosphorylase, glycogen, muscle A
chr4_-_77551860 32.45 ENSDART00000188176

chr17_-_122680 30.08 ENSDART00000066430
actin, alpha, cardiac muscle 1b
chr8_+_54284961 29.22 ENSDART00000122692
plexin D1
chr12_+_13244149 27.12 ENSDART00000186984
ENSDART00000105896
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like
chr4_+_90048 26.85 ENSDART00000166440
low density lipoprotein receptor-related protein 6
chr7_-_2039060 25.95 ENSDART00000173879
si:cabz01007794.1
chr7_+_74150839 25.72 ENSDART00000160195
protein phosphatase 1, catalytic subunit, beta isoform, like
chr5_-_72125551 24.73 ENSDART00000149412
SET and MYND domain containing 1a
chr18_+_5547185 24.03 ENSDART00000193977
nicotinamide nucleotide transhydrogenase 2
chr11_+_36243774 23.89 ENSDART00000023323
zgc:172270
chr10_-_57270 22.00 ENSDART00000058411
holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
chr7_-_73752955 21.77 ENSDART00000171254
ENSDART00000009888
calsequestrin 1b
chr18_-_50845804 20.16 ENSDART00000158517
si:cabz01113374.3
chr8_+_554531 20.06 ENSDART00000193623

chr14_+_52563794 19.43 ENSDART00000168874
ribosomal protein L26
chr8_-_554540 19.31 ENSDART00000163934
Danio rerio uncharacterized LOC100329294 (LOC100329294), mRNA.
chr13_-_51846224 19.10 ENSDART00000184663

chr1_+_55002583 18.88 ENSDART00000037250
si:ch211-196h16.12
chr21_+_25765734 18.43 ENSDART00000021664
claudin b
chr4_-_18211 17.82 ENSDART00000171737
protein tyrosine phosphatase, non-receptor type 12
chr19_+_48117995 17.55 ENSDART00000170865
NME/NM23 nucleoside diphosphate kinase 2b, tandem duplicate 1
chr19_-_5380770 17.53 ENSDART00000000221
keratin 91
chr3_-_1190132 16.61 ENSDART00000149709
single-pass membrane protein with aspartate-rich tail 1a
chr15_-_47479119 16.35 ENSDART00000164957
inositol polyphosphate phosphatase-like 1a
chr4_+_77948517 15.33 ENSDART00000149305
protein kinase C and casein kinase substrate in neurons 2
chr9_+_30294096 15.05 ENSDART00000026551
sushi-repeat containing protein, X-linked
chr3_-_1434135 14.79 ENSDART00000149622
matrix Gla protein
chr12_-_54375 14.67 ENSDART00000152304
si:ch1073-357b18.4
chr9_-_56420087 14.33 ENSDART00000112016
ARP3 actin related protein 3 homolog
chr1_-_59243542 14.17 ENSDART00000163021
multivesicular body subunit 12A
chr12_-_4540564 14.03 ENSDART00000106566

chr4_+_77948970 13.83 ENSDART00000149636
protein kinase C and casein kinase substrate in neurons 2
chr21_-_226071 13.81 ENSDART00000160667
nucleoporin 54
chr13_+_22675802 13.57 ENSDART00000145538
ENSDART00000143312
zgc:193505
chr17_+_53311618 13.44 ENSDART00000166517
ankyrin repeat and SOCS box containing 2b
chr17_-_53348486 13.34 ENSDART00000161183

chr23_-_38054 13.11 ENSDART00000170393

chr8_+_3379815 12.99 ENSDART00000155995
zgc:136963
chr1_+_27690 12.96 ENSDART00000162928
embryonic ectoderm development
chr5_+_480119 12.84 ENSDART00000055681
TEK tyrosine kinase, endothelial
chr3_-_1408487 12.69 ENSDART00000100845
bone gamma-carboxyglutamate (gla) protein
chr7_+_31838320 12.66 ENSDART00000144679
ENSDART00000174217
ENSDART00000122506
myosin binding protein C, cardiac
chr23_+_44580254 12.64 ENSDART00000185069
profilin 1
chr17_+_691453 12.29 ENSDART00000159271
Fanconi anemia, complementation group M
chr25_-_37489917 12.11 ENSDART00000160688
proteasome subunit alpha 1
chr7_+_50849142 12.01 ENSDART00000073806
procollagen C-endopeptidase enhancer b
chr1_+_227241 12.00 ENSDART00000003317
transcription factor Dp-1, b
chr4_-_68569527 11.94 ENSDART00000192091

chr14_+_34514336 11.92 ENSDART00000024440
forkhead box I3b
chr6_-_21189295 11.61 ENSDART00000137136
obscurin-like 1a
chr3_-_60027255 11.60 ENSDART00000189252
ENSDART00000154684
RecQ helicase-like 5
chr24_+_42131564 11.40 ENSDART00000153854
WW domain containing E3 ubiquitin protein ligase 1
chr13_+_41022502 11.39 ENSDART00000026808
dickkopf WNT signaling pathway inhibitor 1a
chr18_-_49078428 11.01 ENSDART00000160702
ENSDART00000174103

chr2_+_7192966 10.78 ENSDART00000142735
si:ch211-13f8.1
chr18_+_173603 10.67 ENSDART00000185918
La ribonucleoprotein domain family, member 6a
chr3_+_18398876 10.61 ENSDART00000141100
ENSDART00000138107
ribosomal protein S2
chr4_+_55758103 10.48 ENSDART00000185964

chr6_+_27514465 10.47 ENSDART00000128985
ENSDART00000079397
receptor-like tyrosine kinase
chr23_+_22873415 10.46 ENSDART00000135130
arginine-glutamic acid dipeptide (RE) repeats a
chr1_-_9104631 10.46 ENSDART00000146642
si:ch211-14k19.8
chr6_+_36821621 10.45 ENSDART00000104157
transmembrane protein 45a
chr20_+_2739804 10.44 ENSDART00000152655
synaptotagmin binding, cytoplasmic RNA interacting protein
chr1_-_48933 10.35 ENSDART00000171162
immunoglobulin-like domain containing receptor 1a
chr14_-_9522364 10.24 ENSDART00000054689
atonal bHLH transcription factor 8
chr25_-_1124851 10.24 ENSDART00000067558
spastic paraplegia 11
chr9_-_216527 10.12 ENSDART00000163068
achalasia, adrenocortical insufficiency, alacrimia
chr3_-_1400309 10.02 ENSDART00000159893
WW domain binding protein 11
chr4_-_64703 10.00 ENSDART00000167851

chr25_+_150570 9.93 ENSDART00000170892
ADAM metallopeptidase domain 10b
chr2_-_51511494 9.91 ENSDART00000161392
ENSDART00000160877
si:ch211-9d9.8
chr13_-_214122 9.85 ENSDART00000169273
protein phosphatase 1, regulatory subunit 21
chr8_-_28449782 9.80 ENSDART00000062702
CCAAT/enhancer binding protein (C/EBP), beta
chr2_-_51700709 9.75 ENSDART00000188601
transglutaminase 1 like 1
chr25_-_37501371 9.70 ENSDART00000160498

chr2_+_36007449 9.58 ENSDART00000161837
laminin, gamma 2
chr9_+_22764235 9.45 ENSDART00000090875
tumor necrosis factor, alpha-induced protein 6
chr7_-_5162292 9.41 ENSDART00000084218
zgc:195075
chr11_+_45233348 9.30 ENSDART00000173150
transmembrane channel-like 6b
chr24_+_38671054 9.20 ENSDART00000154214
si:ch73-70c5.1
chr15_-_44663712 9.15 ENSDART00000192124

chr25_-_37465064 9.13 ENSDART00000186128
zgc:158366
chr21_-_44009169 9.03 ENSDART00000028960
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2
chr24_-_41478917 8.91 ENSDART00000192192

chr7_-_55454406 8.88 ENSDART00000108646
piezo-type mechanosensitive ion channel component 1
chr25_+_1732838 8.65 ENSDART00000159555
ENSDART00000168161
fibulin 1
chr22_+_661505 8.59 ENSDART00000149460
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr1_+_59538755 8.52 ENSDART00000166354
Sp6 transcription factor
chr9_-_23807032 8.49 ENSDART00000027443
extended synaptotagmin-like protein 3
chr3_+_301479 8.36 ENSDART00000165169

chr19_+_32856907 8.31 ENSDART00000148232
ribosomal protein L30
chr17_+_132555 8.29 ENSDART00000158159
zgc:77287
chr21_+_233271 8.26 ENSDART00000171440
DTW domain containing 2
chr22_+_10090673 8.25 ENSDART00000186680
si:dkey-102c8.3
chr19_-_5364649 8.09 ENSDART00000004812
type I cytokeratin, enveloping layer
chr6_+_27338512 8.08 ENSDART00000155004
kelch-like family member 30
chr25_+_236753 8.06 ENSDART00000153663
pseudouridylate synthase 7 (putative)
chr17_+_15388479 8.06 ENSDART00000052439
si:ch211-266g18.6
chr25_-_37422859 8.04 ENSDART00000156018
CD44 molecule (Indian blood group) b
chr20_+_2669017 7.97 ENSDART00000058777
solute carrier family 35 (CMP-sialic acid transporter), member A1
chr17_+_53418445 7.88 ENSDART00000097631
solute carrier family 9 member A1b
chr17_+_53311243 7.86 ENSDART00000160241
ENSDART00000160009
ENSDART00000162239
ankyrin repeat and SOCS box containing 2b
chr9_+_23714406 7.81 ENSDART00000189445
glycophorin C (Gerbich blood group)
chr10_+_24445698 7.71 ENSDART00000146370
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr21_+_25625026 7.46 ENSDART00000134678
ovo-like zinc finger 1b
chr5_+_23630384 7.38 ENSDART00000013745
connexin 39.9
chr5_+_337215 7.33 ENSDART00000167982
ring finger protein 170
chr9_+_10692905 7.27 ENSDART00000061499
chemokine (C-X-C motif), receptor 4b
chr17_-_5860222 7.27 ENSDART00000058894
si:ch73-340m8.2
chr7_+_53199763 7.22 ENSDART00000160097
cadherin 28
chr15_+_47362728 7.19 ENSDART00000180712

chr1_+_59533317 7.15 ENSDART00000166821
Sp6 transcription factor
chr2_-_58581663 7.13 ENSDART00000004431
erythrocyte membrane protein band 4.1-like 3b
chr16_-_54357200 6.84 ENSDART00000170753

chr11_+_45461853 6.76 ENSDART00000173409
son of sevenless homolog 1 (Drosophila)
chr20_-_54377933 6.73 ENSDART00000182664
ectonucleoside triphosphate diphosphohydrolase 5b
chr16_-_30885838 6.73 ENSDART00000131356
DENN/MADD domain containing 3b
chr8_+_44475793 6.70 ENSDART00000190118
si:ch73-211l2.3
chr10_-_45058886 6.59 ENSDART00000159347
mitochondrial ribosomal protein S24
chr19_+_638339 6.57 ENSDART00000148705
telomerase reverse transcriptase
chr8_+_45294767 6.48 ENSDART00000191527
ubiquitin associated protein 2b
chr2_-_8648440 6.48 ENSDART00000135743
si:ch211-71m22.3
chr10_+_23537576 6.39 ENSDART00000130515

chr14_+_48812189 6.26 ENSDART00000161454
matrix metallopeptidase 17b
chr3_+_60007703 6.23 ENSDART00000157351
ENSDART00000153928
ENSDART00000155876
si:ch211-110e21.3
chr11_+_45343245 6.21 ENSDART00000160904
si:ch73-100l22.3
chr20_-_38746889 6.19 ENSDART00000140275
tripartite motif containing 54
chr2_+_47754419 6.17 ENSDART00000188221
muscleblind-like splicing regulator 1
chr19_-_81851 6.15 ENSDART00000172319
heterogeneous nuclear ribonucleoprotein R
chr19_+_917852 6.10 ENSDART00000082466
transforming growth factor beta receptor 2a
chr23_-_9768700 6.08 ENSDART00000045126
laminin, alpha 5
chr25_+_4750972 6.04 ENSDART00000168903
si:zfos-2372e4.1
chr12_+_2677303 6.03 ENSDART00000093113
anthrax toxin receptor 1c
chr15_-_34458495 5.99 ENSDART00000059954
mesenchyme homeobox 2a
chr9_+_51891 5.97 ENSDART00000163529
zgc:158316
chr10_-_74408 5.95 ENSDART00000100073
ENSDART00000141723
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, a
chr11_-_40147032 5.94 ENSDART00000052918
si:dkey-264d12.4
chr25_+_29474583 5.90 ENSDART00000191189
interleukin 17 receptor E-like
chr1_-_40016058 5.90 ENSDART00000165373
cyclin-dependent kinase 2 associated protein 2
chr4_-_53370 5.88 ENSDART00000180254
ENSDART00000186529

chr23_-_969844 5.86 ENSDART00000127037
cadherin 26, tandem duplicate 2
chr17_+_51517750 5.81 ENSDART00000180896
ENSDART00000193528
peroxidasin
chr6_+_59984772 5.81 ENSDART00000048449
mitochondrial translational release factor 1
chr2_+_59041081 5.81 ENSDART00000067736
serine/threonine kinase 11
chr10_+_22772084 5.77 ENSDART00000144845
ENSDART00000165222
transmembrane protein 88 a
chr1_-_5543065 5.74 ENSDART00000103755
fibronectin 1b
chr6_+_392815 5.70 ENSDART00000163142
cytohesin 4b
chr18_-_226800 5.68 ENSDART00000165180
threonyl-tRNA synthetase-like 2
chr14_+_94946 5.62 ENSDART00000165766
ENSDART00000163778
minichromosome maintenance complex component 7
chr6_-_43677125 5.62 ENSDART00000150128
forkhead box P1b
chr25_-_10724947 5.57 ENSDART00000184490
low density lipoprotein receptor-related protein 5
chr3_-_30685401 5.54 ENSDART00000151097
si:ch211-51c14.1
chr22_+_997838 5.52 ENSDART00000149743
peroxisome proliferator-activated receptor delta a
chr5_-_26181863 5.51 ENSDART00000098500
coiled-coil domain containing 125
chr23_-_306796 5.51 ENSDART00000143125
ankyrin repeat and sterile alpha motif domain containing 1Aa
chr6_-_442163 5.42 ENSDART00000163564
ENSDART00000189134
ENSDART00000169789
GRB2-related adaptor protein 2b
chr5_-_69621227 5.41 ENSDART00000178543
aldehyde dehydrogenase 2 family (mitochondrial), tandem duplicate 2
chr11_-_19501439 5.39 ENSDART00000158328
ENSDART00000103983
solute carrier family 2 (facilitated glucose transporter), member 9-like 1
chr4_+_76619791 5.23 ENSDART00000184042
membrane-spanning 4-domains, subfamily A, member 17A.8
chr3_+_1223824 5.21 ENSDART00000065922
WBP2 N-terminal like
chr23_-_46201008 5.18 ENSDART00000160110
transglutaminase 1 like 4
chr1_+_176583 5.16 ENSDART00000168760
ENSDART00000160425
lysosomal associated membrane protein 1
chr6_-_53326421 5.16 ENSDART00000191740
guanine nucleotide binding protein (G protein), beta polypeptide 1b
chr25_+_5044780 5.04 ENSDART00000153980
parvin, beta
chr13_-_45523026 4.98 ENSDART00000020663
Rh blood group, D antigen
chr19_+_2619444 4.95 ENSDART00000169483
family with sequence similarity 126, member A
chr19_-_5358443 4.94 ENSDART00000105036
type I cytokeratin, enveloping layer, like
chr4_-_170120 4.94 ENSDART00000171333
epidermal growth factor receptor pathway substrate 8
chr7_+_35229645 4.94 ENSDART00000144327
tubulin polymerization-promoting protein family member 3
chr5_-_417495 4.91 ENSDART00000180586
ENSDART00000189408
hook microtubule tethering protein 3
chr9_+_21281652 4.89 ENSDART00000113352
large tumor suppressor kinase 2
chr9_+_56194410 4.87 ENSDART00000168530

chr12_+_49135755 4.84 ENSDART00000153460
si:zfos-911d5.4
chr4_+_76722754 4.83 ENSDART00000153867
membrane-spanning 4-domains, subfamily A, member 17A.3
chr21_+_45510448 4.81 ENSDART00000160494
ENSDART00000167914
folliculin interacting protein 1
chr5_+_19337108 4.78 ENSDART00000089078
acetyl-CoA carboxylase beta
chr21_+_170038 4.77 ENSDART00000157614
kelch-like family member 8
chr17_-_4395373 4.75 ENSDART00000015923
kelch-like family member 10a
chr12_+_2676878 4.72 ENSDART00000185909
anthrax toxin receptor 1c
chr18_-_45617146 4.72 ENSDART00000146543
wilms tumor 1b
chr12_+_23892972 4.71 ENSDART00000152852
supervillin a
chr8_-_53488832 4.68 ENSDART00000191801
choline dehydrogenase
chr12_-_48312647 4.68 ENSDART00000114415
activating signal cointegrator 1 complex subunit 1
chr18_-_127558 4.66 ENSDART00000149556
transient receptor potential cation channel, subfamily M, member 7
chr12_+_10053852 4.66 ENSDART00000078497
solute carrier family 4 (anion exchanger), member 1b (Diego blood group)
chr15_-_47468085 4.61 ENSDART00000164438
inositol polyphosphate phosphatase-like 1a
chr9_+_36946340 4.61 ENSDART00000135281
si:dkey-3d4.3
chr25_+_25464630 4.60 ENSDART00000150537
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7a
chr11_+_29537756 4.58 ENSDART00000103388
wu:fi42e03
chr5_+_71802014 4.53 ENSDART00000124939
ENSDART00000097164
LIM homeobox 3
chr7_-_74090168 4.44 ENSDART00000050528
tyrosinase-related protein 1a
chr5_-_6508250 4.36 ENSDART00000060535
crystallin, beta B3
chr7_+_22293894 4.36 ENSDART00000056790
transmembrane protein 256
chr15_-_18223769 4.30 ENSDART00000139966
odorant receptor, family H, subfamily 131, member 1
chr7_+_35229805 4.19 ENSDART00000173911
tubulin polymerization-promoting protein family member 3

Network of associatons between targets according to the STRING database.

First level regulatory network of rreb1a+rreb1b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
10.9 32.6 GO:0052575 carbohydrate localization(GO:0052575) carbohydrate storage(GO:0052576)
7.3 21.8 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722) regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
6.0 24.0 GO:0006740 NADPH regeneration(GO:0006740)
5.3 53.1 GO:0070836 membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
4.7 14.2 GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510)
4.6 13.8 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228) protein localization to nuclear envelope(GO:0090435)
4.0 28.2 GO:0071623 negative regulation of leukocyte chemotaxis(GO:0002689) negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024) negative regulation of neutrophil migration(GO:1902623)
3.4 10.2 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
3.0 11.9 GO:0009957 epidermal cell fate specification(GO:0009957)
2.5 12.7 GO:0003210 cardiac atrium formation(GO:0003210)
2.2 6.6 GO:0007571 age-dependent general metabolic decline(GO:0007571)
1.9 5.8 GO:0070126 mitochondrial translational termination(GO:0070126)
1.9 21.2 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
1.9 5.8 GO:2000726 negative regulation of striated muscle cell differentiation(GO:0051154) negative regulation of cardiac muscle tissue development(GO:0055026) cardiac muscle cell fate commitment(GO:0060923) canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:0061317) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901296) negative regulation of cardiocyte differentiation(GO:1905208) negative regulation of cardiac muscle cell differentiation(GO:2000726)
1.9 7.6 GO:1903723 negative regulation of centriole elongation(GO:1903723)
1.9 5.6 GO:0035676 anterior lateral line neuromast hair cell development(GO:0035676)
1.8 5.5 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
1.8 8.9 GO:0010481 ventriculo bulbo valve development(GO:0003173) epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
1.7 11.6 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
1.6 6.5 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
1.6 4.7 GO:0019695 choline metabolic process(GO:0019695)
1.4 29.2 GO:1902287 semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
1.3 10.5 GO:0031063 regulation of histone deacetylation(GO:0031063)
1.2 12.3 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
1.2 10.7 GO:1901998 toxin transport(GO:1901998)
1.2 4.8 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
1.2 1.2 GO:0010885 regulation of cholesterol storage(GO:0010885)
1.2 12.7 GO:0033273 response to vitamin(GO:0033273)
1.1 17.9 GO:0050728 negative regulation of inflammatory response(GO:0050728)
1.1 17.6 GO:0006228 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
1.1 8.6 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
1.0 10.5 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
1.0 5.2 GO:0007343 egg activation(GO:0007343)
1.0 7.0 GO:0006953 acute-phase response(GO:0006953)
0.9 16.6 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.9 13.7 GO:0090481 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.9 2.7 GO:1900364 negative regulation of mRNA 3'-end processing(GO:0031441) negative regulation of mRNA polyadenylation(GO:1900364)
0.9 3.5 GO:1904667 negative regulation of ligase activity(GO:0051352) negative regulation of ubiquitin-protein transferase activity(GO:0051444) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.8 2.4 GO:0003218 cardiac left ventricle morphogenesis(GO:0003214) cardiac left ventricle formation(GO:0003218)
0.8 21.3 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.8 12.8 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.7 2.2 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.7 3.6 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.7 7.9 GO:0098719 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.7 5.0 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.7 14.9 GO:0018149 peptide cross-linking(GO:0018149)
0.7 10.0 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.6 5.8 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.6 5.2 GO:1902624 positive regulation of neutrophil migration(GO:1902624)
0.6 29.4 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.6 11.4 GO:1990399 sensory epithelium regeneration(GO:0070654) epithelium regeneration(GO:1990399)
0.6 2.9 GO:0031640 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364) disruption of cells of other organism involved in symbiotic interaction(GO:0051818) killing of cells in other organism involved in symbiotic interaction(GO:0051883)
0.6 3.5 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.6 5.5 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.5 1.6 GO:0043385 mycotoxin metabolic process(GO:0043385) aflatoxin metabolic process(GO:0046222) organic heteropentacyclic compound metabolic process(GO:1901376)
0.5 5.6 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.5 4.4 GO:0006582 melanin metabolic process(GO:0006582) melanin biosynthetic process(GO:0042438)
0.5 8.6 GO:0097320 membrane tubulation(GO:0097320)
0.5 4.1 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.5 12.6 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.4 2.7 GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
0.4 4.9 GO:0046620 regulation of organ growth(GO:0046620)
0.4 6.6 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.4 0.9 GO:0090190 regulation of morphogenesis of a branching structure(GO:0060688) positive regulation of mesonephros development(GO:0061213) regulation of mesonephros development(GO:0061217) regulation of kidney development(GO:0090183) positive regulation of kidney development(GO:0090184) regulation of branching involved in ureteric bud morphogenesis(GO:0090189) positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.4 1.7 GO:0021534 cell proliferation in hindbrain(GO:0021534)
0.4 17.8 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.4 2.4 GO:1900045 negative regulation of histone ubiquitination(GO:0033183) regulation of protein K63-linked ubiquitination(GO:1900044) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) regulation of protein polyubiquitination(GO:1902914) negative regulation of protein polyubiquitination(GO:1902915)
0.4 6.7 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.4 10.7 GO:0044332 Wnt signaling pathway involved in dorsal/ventral axis specification(GO:0044332)
0.4 12.1 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.4 18.4 GO:0070830 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.4 1.1 GO:1903430 branchiomotor neuron axon guidance(GO:0021785) negative regulation of cell maturation(GO:1903430)
0.3 9.9 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.3 14.3 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.3 11.9 GO:0046785 microtubule polymerization(GO:0046785)
0.3 2.6 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.3 8.1 GO:0001522 pseudouridine synthesis(GO:0001522)
0.3 1.9 GO:1900028 wound healing, spreading of epidermal cells(GO:0035313) negative regulation of ruffle assembly(GO:1900028)
0.3 3.8 GO:0021592 fourth ventricle development(GO:0021592)
0.3 4.7 GO:0061055 myotome development(GO:0061055)
0.3 6.1 GO:0035141 medial fin morphogenesis(GO:0035141)
0.3 9.4 GO:0017121 phospholipid scrambling(GO:0017121)
0.3 4.1 GO:0032332 positive regulation of chondrocyte differentiation(GO:0032332)
0.3 1.1 GO:0006272 leading strand elongation(GO:0006272)
0.3 1.1 GO:0046551 retinal cone cell fate determination(GO:0042671) eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate determination(GO:0043703) retinal cone cell fate commitment(GO:0046551) photoreceptor cell fate commitment(GO:0046552) camera-type eye photoreceptor cell fate commitment(GO:0060220)
0.3 2.1 GO:0072401 signal transduction involved in DNA integrity checkpoint(GO:0072401) signal transduction involved in DNA damage checkpoint(GO:0072422) signal transduction involved in G2 DNA damage checkpoint(GO:0072425)
0.2 9.1 GO:0001878 response to yeast(GO:0001878)
0.2 5.8 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.2 4.7 GO:0048246 macrophage chemotaxis(GO:0048246)
0.2 2.2 GO:0045471 response to ethanol(GO:0045471)
0.2 10.2 GO:0036269 swimming behavior(GO:0036269)
0.2 6.6 GO:0032543 mitochondrial translation(GO:0032543)
0.2 5.0 GO:0030032 lamellipodium assembly(GO:0030032)
0.2 4.1 GO:0006198 cAMP catabolic process(GO:0006198)
0.2 4.7 GO:0015701 bicarbonate transport(GO:0015701)
0.2 2.6 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.2 9.6 GO:0043113 receptor clustering(GO:0043113)
0.2 8.0 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.2 3.2 GO:0019433 triglyceride catabolic process(GO:0019433)
0.2 10.0 GO:0010842 retina layer formation(GO:0010842)
0.2 5.0 GO:0030574 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.2 0.3 GO:0046066 purine deoxyribonucleoside diphosphate metabolic process(GO:0009182) dGDP metabolic process(GO:0046066)
0.1 2.0 GO:0045667 regulation of osteoblast differentiation(GO:0045667)
0.1 2.1 GO:0043248 proteasome assembly(GO:0043248)
0.1 2.3 GO:0071594 T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594)
0.1 0.9 GO:0000706 meiotic DNA double-strand break processing(GO:0000706)
0.1 2.0 GO:0051382 kinetochore assembly(GO:0051382)
0.1 1.1 GO:0072393 microtubule anchoring at microtubule organizing center(GO:0072393)
0.1 2.0 GO:0021999 neural plate anterior/posterior regionalization(GO:0021999)
0.1 11.4 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.1 2.0 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.1 9.2 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 1.5 GO:0060971 embryonic heart tube left/right pattern formation(GO:0060971)
0.1 11.9 GO:0007163 establishment or maintenance of cell polarity(GO:0007163)
0.1 8.1 GO:0042074 cell migration involved in gastrulation(GO:0042074)
0.1 7.6 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.1 7.0 GO:0016571 histone methylation(GO:0016571)
0.1 4.1 GO:0032272 negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272)
0.1 1.8 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.1 13.7 GO:0061053 somite development(GO:0061053)
0.1 6.1 GO:0071560 transforming growth factor beta receptor signaling pathway(GO:0007179) response to transforming growth factor beta(GO:0071559) cellular response to transforming growth factor beta stimulus(GO:0071560)
0.1 7.5 GO:0009913 epidermal cell differentiation(GO:0009913)
0.1 16.8 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.1 6.2 GO:0048846 axon extension involved in axon guidance(GO:0048846) neuron projection extension involved in neuron projection guidance(GO:1902284)
0.1 3.2 GO:0008360 regulation of cell shape(GO:0008360)
0.1 9.7 GO:0051169 nucleocytoplasmic transport(GO:0006913) nuclear transport(GO:0051169)
0.1 2.3 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.1 3.7 GO:0042493 response to drug(GO:0042493)
0.1 0.7 GO:0072386 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.1 3.1 GO:0007050 cell cycle arrest(GO:0007050)
0.1 6.9 GO:0070374 positive regulation of ERK1 and ERK2 cascade(GO:0070374)
0.1 4.0 GO:0033339 pectoral fin development(GO:0033339)
0.1 22.2 GO:0046777 protein autophosphorylation(GO:0046777)
0.1 2.2 GO:0045332 phospholipid translocation(GO:0045332)
0.1 0.7 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.1 3.2 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.1 1.4 GO:0009226 nucleotide-sugar biosynthetic process(GO:0009226)
0.1 2.9 GO:0043648 dicarboxylic acid metabolic process(GO:0043648)
0.1 1.4 GO:0006884 cell volume homeostasis(GO:0006884)
0.1 4.5 GO:0001503 ossification(GO:0001503)
0.1 10.7 GO:0016570 histone modification(GO:0016570)
0.0 1.3 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 1.0 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.0 3.6 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 4.4 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 0.4 GO:0045879 negative regulation of smoothened signaling pathway(GO:0045879)
0.0 1.6 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 5.3 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 6.6 GO:0006954 inflammatory response(GO:0006954)
0.0 0.3 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 4.0 GO:0045165 cell fate commitment(GO:0045165)
0.0 7.3 GO:0045087 innate immune response(GO:0045087)
0.0 1.2 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 3.5 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 3.2 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 4.2 GO:0009952 anterior/posterior pattern specification(GO:0009952)
0.0 1.5 GO:0090263 positive regulation of canonical Wnt signaling pathway(GO:0090263)
0.0 16.1 GO:0016567 protein ubiquitination(GO:0016567)
0.0 3.4 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.0 8.5 GO:0051726 regulation of cell cycle(GO:0051726)
0.0 0.6 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 3.4 GO:0006457 protein folding(GO:0006457)
0.0 0.9 GO:0009395 phospholipid catabolic process(GO:0009395)
0.0 4.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.6 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.6 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 1.8 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.0 0.5 GO:0000070 mitotic sister chromatid segregation(GO:0000070)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 21.8 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
2.2 6.6 GO:0000333 telomerase catalytic core complex(GO:0000333)
1.9 30.1 GO:0005869 dynactin complex(GO:0005869)
1.5 13.8 GO:0044613 nuclear pore central transport channel(GO:0044613)
1.4 29.2 GO:0002116 semaphorin receptor complex(GO:0002116)
1.3 6.5 GO:1990923 PET complex(GO:1990923)
1.3 16.6 GO:1990246 uniplex complex(GO:1990246)
1.2 53.1 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
1.2 3.6 GO:0043034 costamere(GO:0043034)
1.2 24.7 GO:0031430 M band(GO:0031430)
1.1 12.1 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
1.0 2.9 GO:0030062 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
1.0 16.2 GO:0000813 ESCRT I complex(GO:0000813)
0.9 13.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.9 8.6 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.9 21.5 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.8 14.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.4 2.7 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.4 4.4 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.4 2.8 GO:0035060 brahma complex(GO:0035060)
0.3 5.6 GO:0042555 MCM complex(GO:0042555)
0.3 1.8 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.3 3.4 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.3 6.6 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.3 6.1 GO:0005605 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.3 34.2 GO:0016607 nuclear speck(GO:0016607)
0.3 2.1 GO:0070552 BRISC complex(GO:0070552)
0.2 25.3 GO:0005882 intermediate filament(GO:0005882)
0.2 10.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 0.6 GO:0010369 chromocenter(GO:0010369)
0.2 9.0 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2 15.8 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.2 10.1 GO:0005643 nuclear pore(GO:0005643)
0.2 2.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.2 18.7 GO:0005924 cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925)
0.2 4.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 0.6 GO:0097519 DNA recombinase complex(GO:0097519)
0.1 8.0 GO:0005902 microvillus(GO:0005902)
0.1 1.9 GO:0030057 desmosome(GO:0030057)
0.1 0.9 GO:0000801 central element(GO:0000801)
0.1 18.4 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.1 3.2 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 8.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625) cytosolic ribosome(GO:0022626)
0.1 24.6 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.1 2.8 GO:0045180 basal cortex(GO:0045180)
0.1 6.1 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 1.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 9.3 GO:0000786 nucleosome(GO:0000786)
0.1 7.6 GO:0005814 centriole(GO:0005814)
0.1 8.7 GO:0016324 apical plasma membrane(GO:0016324)
0.1 0.6 GO:0038039 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor heterodimeric complex(GO:0038039) G-protein coupled receptor complex(GO:0097648)
0.1 3.4 GO:0005811 lipid particle(GO:0005811)
0.1 3.8 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 4.9 GO:0000922 spindle pole(GO:0000922)
0.1 17.8 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.1 5.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 1.1 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 2.6 GO:0030018 Z disc(GO:0030018)
0.0 1.2 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 2.4 GO:0032993 protein-DNA complex(GO:0032993)
0.0 2.0 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 1.7 GO:0031941 filamentous actin(GO:0031941)
0.0 5.1 GO:0005681 spliceosomal complex(GO:0005681)
0.0 6.3 GO:0000785 chromatin(GO:0000785)
0.0 4.4 GO:0005769 early endosome(GO:0005769)
0.0 2.0 GO:0005912 adherens junction(GO:0005912)
0.0 7.0 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.5 GO:0072686 mitotic spindle(GO:0072686)
0.0 3.2 GO:0005764 lysosome(GO:0005764)
0.0 5.2 GO:1990904 ribonucleoprotein complex(GO:1990904)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.5 32.6 GO:0008184 phosphorylase activity(GO:0004645) glycogen phosphorylase activity(GO:0008184)
6.0 24.0 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
3.6 17.8 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
3.3 9.9 GO:1902945 metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902945)
2.7 23.9 GO:0009378 four-way junction helicase activity(GO:0009378)
2.3 11.4 GO:0039706 co-receptor binding(GO:0039706)
2.2 6.6 GO:0003721 telomerase RNA reverse transcriptase activity(GO:0003721)
1.3 21.5 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
1.2 12.1 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
1.2 4.8 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
1.2 12.7 GO:0032036 myosin heavy chain binding(GO:0032036)
1.1 18.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
1.1 5.6 GO:1990518 ATP-dependent 3'-5' DNA helicase activity(GO:0043140) single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity(GO:1990518)
1.0 5.2 GO:0050699 WW domain binding(GO:0050699)
1.0 6.1 GO:0050431 transforming growth factor beta binding(GO:0050431)
1.0 4.8 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.9 29.2 GO:0017154 semaphorin receptor activity(GO:0017154)
0.8 6.5 GO:0034584 piRNA binding(GO:0034584)
0.8 8.6 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.8 9.4 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.8 8.5 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.7 14.9 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.7 5.7 GO:0001948 glycoprotein binding(GO:0001948) proteoglycan binding(GO:0043394)
0.7 7.9 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.7 3.4 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184) 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.6 17.9 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.6 10.8 GO:0005080 protein kinase C binding(GO:0005080)
0.6 10.5 GO:0017147 Wnt-protein binding(GO:0017147)
0.6 5.8 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.6 18.2 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.5 2.7 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.5 13.8 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.5 5.9 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.4 31.8 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.4 8.1 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.4 10.9 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.4 6.7 GO:0045134 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.4 5.4 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.4 2.2 GO:0001784 phosphotyrosine binding(GO:0001784)
0.3 5.2 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.3 30.5 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.3 22.0 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.3 8.1 GO:0042043 neurexin family protein binding(GO:0042043)
0.3 10.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.3 3.2 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.3 8.3 GO:0030165 PDZ domain binding(GO:0030165)
0.3 4.1 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.3 5.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.3 3.6 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.2 1.4 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.2 2.0 GO:0043515 kinetochore binding(GO:0043515)
0.2 10.5 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.2 4.7 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.2 0.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 2.7 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.2 2.8 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.2 0.9 GO:0030116 glial cell-derived neurotrophic factor receptor binding(GO:0030116)
0.2 4.1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.2 4.2 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.2 1.6 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.2 2.2 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.1 0.8 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 5.6 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 14.1 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.1 2.4 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.1 25.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 2.7 GO:0008143 poly(A) binding(GO:0008143)
0.1 61.1 GO:0005198 structural molecule activity(GO:0005198)
0.1 10.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 5.8 GO:0004601 peroxidase activity(GO:0004601)
0.1 3.8 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 7.8 GO:0001594 trace-amine receptor activity(GO:0001594)
0.1 1.4 GO:0005221 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.1 8.3 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.1 2.6 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 2.1 GO:0070492 oligosaccharide binding(GO:0070492)
0.1 7.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 2.5 GO:0042923 neuropeptide binding(GO:0042923)
0.1 0.6 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 1.1 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 3.0 GO:0017124 SH3 domain binding(GO:0017124)
0.1 2.4 GO:0016307 phosphatidylinositol phosphate kinase activity(GO:0016307)
0.1 0.7 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 5.2 GO:0045296 cadherin binding(GO:0045296)
0.1 1.5 GO:0015248 sterol transporter activity(GO:0015248)
0.1 7.4 GO:0060090 binding, bridging(GO:0060090)
0.1 18.7 GO:0051015 actin filament binding(GO:0051015)
0.0 6.5 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.0 19.9 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 8.9 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 3.4 GO:0051082 unfolded protein binding(GO:0051082)
0.0 5.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 9.9 GO:0003779 actin binding(GO:0003779)
0.0 2.0 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 1.2 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 2.7 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 1.7 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 3.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 39.0 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 0.4 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 3.9 GO:0004175 endopeptidase activity(GO:0004175)
0.0 0.2 GO:0070122 isopeptidase activity(GO:0070122)
0.0 0.4 GO:0015645 fatty acid ligase activity(GO:0015645)
0.0 1.3 GO:0001159 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 42.9 PID WNT SIGNALING PATHWAY Wnt signaling network
1.3 15.7 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
1.1 27.0 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
1.0 28.7 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.5 12.8 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.5 9.3 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.4 9.8 PID IL3 PATHWAY IL3-mediated signaling events
0.4 30.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4 11.4 PID ERBB4 PATHWAY ErbB4 signaling events
0.4 6.6 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.3 5.6 PID ATR PATHWAY ATR signaling pathway
0.3 2.5 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.3 39.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 12.3 PID FANCONI PATHWAY Fanconi anemia pathway
0.2 3.6 PID CD40 PATHWAY CD40/CD40L signaling
0.1 4.9 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 5.8 PID LKB1 PATHWAY LKB1 signaling events
0.1 3.5 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 3.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 2.3 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 1.1 PID BARD1 PATHWAY BARD1 signaling events
0.1 3.5 PID PLK1 PATHWAY PLK1 signaling events
0.1 4.9 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 1.2 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 3.1 PID E2F PATHWAY E2F transcription factor network
0.0 0.8 PID MYC PATHWAY C-MYC pathway
0.0 0.8 PID TNF PATHWAY TNF receptor signaling pathway
0.0 3.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.8 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.6 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.4 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 20.2 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
1.6 29.2 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.8 22.2 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.7 10.6 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.6 23.9 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.6 12.3 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.5 3.5 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.5 12.1 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.4 3.4 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.4 5.6 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.4 5.0 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.4 12.6 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.3 15.6 REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.3 38.4 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.3 3.7 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.3 7.7 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.3 1.7 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.2 4.9 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.2 7.6 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.2 3.4 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.2 9.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.2 11.4 REACTOME SIGNALING BY ERBB4 Genes involved in Signaling by ERBB4
0.1 1.3 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 10.0 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 3.6 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 2.9 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 4.2 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.1 2.0 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 2.0 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 5.0 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.4 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0 4.6 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 1.2 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 1.4 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.7 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.8 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.8 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)