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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for runx3

Z-value: 0.78

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Transcription factors associated with runx3

Gene Symbol Gene ID Gene Info
ENSDARG00000052826 RUNX family transcription factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
runx3dr11_v1_chr13_-_45155284_451552840.802.1e-22Click!

Activity profile of runx3 motif

Sorted Z-values of runx3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_43711918 28.97 ENSDART00000193110

chr16_+_28754403 9.78 ENSDART00000103340
S100 calcium binding protein V1
chr15_-_2657508 7.09 ENSDART00000102086
claudin a
chr11_-_30636163 7.08 ENSDART00000140516
zgc:153665
chr3_-_22228602 6.82 ENSDART00000017750
myosin, light chain 4, alkali; atrial, embryonic
chr19_-_5380770 6.49 ENSDART00000000221
keratin 91
chr15_+_6117502 5.20 ENSDART00000188293
Purkinje cell protein 4
chr20_-_34670236 4.94 ENSDART00000033325
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr23_-_36313431 4.36 ENSDART00000125860
nuclear factor, erythroid 2
chr16_+_23431189 4.28 ENSDART00000004679
ictacalcin
chr6_-_2154137 4.22 ENSDART00000162656
transglutaminase 5, like
chr19_+_37118547 4.20 ENSDART00000103163
connexin 30.9
chr7_+_24888910 4.15 ENSDART00000173994
MAP/microtubule affinity-regulating kinase 2b
chr12_+_46883785 3.87 ENSDART00000008312
family with sequence similarity 53, member B
chr1_-_50710468 3.26 ENSDART00000080389
family with sequence similarity 13, member A
chr15_+_37589698 3.16 ENSDART00000076066
ENSDART00000153894
ENSDART00000156298
lin-37 DREAM MuvB core complex component
chr8_+_18830759 3.05 ENSDART00000089079
MPN domain containing
chr16_-_54907588 3.04 ENSDART00000185709
keratinocyte differentiation factor 1a
chr6_+_44163727 2.97 ENSDART00000064878
glucoside xylosyltransferase 2
chr11_-_40519886 2.92 ENSDART00000172819
migration and invasion inhibitory protein
chr7_+_25858380 2.61 ENSDART00000148780
ENSDART00000079218
myotubularin related protein 1a
chr9_+_37141836 2.56 ENSDART00000024555
GLI family zinc finger 2a
chr15_-_20468302 2.50 ENSDART00000018514
deltaC
chr16_+_35870456 2.49 ENSDART00000184321
thyroid hormone receptor associated protein 3a
chr15_-_37589600 2.48 ENSDART00000154641
proline and serine rich 3
chr19_+_2590182 2.47 ENSDART00000162293
si:ch73-345f18.3
chr19_+_4062101 2.33 ENSDART00000166773
bloodthirsty-related gene family, member 25
chr3_+_6291635 2.33 ENSDART00000185055
ENSDART00000157707
si:ch211-12p12.2
chr24_-_14212521 2.27 ENSDART00000130825
XK, Kell blood group complex subunit-related family, member 9
chr12_-_43819253 2.25 ENSDART00000160261
ENSDART00000170045
ENSDART00000159106
si:ch73-329n5.6
chr16_+_50089417 2.13 ENSDART00000153675
nuclear receptor subfamily 1, group D, member 2a
chr4_-_13518381 2.05 ENSDART00000067153
interferon, gamma 1-1
chr22_-_30973791 1.99 ENSDART00000104728
ssu-2 homolog, tandem duplicate 2
chr12_-_23009312 1.95 ENSDART00000111801
mohawk homeobox a
chr7_+_52712807 1.85 ENSDART00000174095
ENSDART00000174377
ENSDART00000174061
ENSDART00000174094
ENSDART00000110906
ENSDART00000174071
ENSDART00000174238
zinc finger protein 280D
chr13_+_8255106 1.82 ENSDART00000080465
helicase, lymphoid specific
chr2_+_49864219 1.77 ENSDART00000187744
ribosomal protein L37
chr20_-_2725930 1.69 ENSDART00000081643
akirin 2
chr22_+_29994093 1.69 ENSDART00000104778
si:dkey-286j15.3
chr6_+_39930825 1.68 ENSDART00000182352
ENSDART00000186643
ENSDART00000190513
ENSDART00000065092
ENSDART00000188645
inositol 1,4,5-trisphosphate receptor, type 1a
chr12_+_18744610 1.62 ENSDART00000153456
megakaryoblastic leukemia (translocation) 1b
chr18_-_50524017 1.56 ENSDART00000150013
ENSDART00000149912
CD276 molecule
chr12_+_28910762 1.56 ENSDART00000076342
ENSDART00000160939
ENSDART00000076572
ring finger protein 40
chr2_+_16173999 1.43 ENSDART00000177639
ENSDART00000157601
ENSDART00000190186
ENSDART00000045933
SH3-domain GRB2-like endophilin B1b
chr1_-_39859626 1.42 ENSDART00000053763
dCMP deaminase
chr14_-_24332786 1.40 ENSDART00000173164
family with sequence similarity 13, member B
chr24_-_18659147 1.39 ENSDART00000166039
zgc:66014
chr10_-_309894 1.37 ENSDART00000163287

chr19_+_4068134 1.36 ENSDART00000158285
bloodthirsty-related gene family, member 26
chr20_-_48485354 1.36 ENSDART00000124040
ENSDART00000148437
insulinoma-associated 1a
chr15_+_29292154 1.35 ENSDART00000137817
RAP1 GTPase activating protein 2a
chr2_-_52841762 1.35 ENSDART00000114682
ralA binding protein 1
chr16_-_32672883 1.31 ENSDART00000124515
ENSDART00000190920
ENSDART00000188776
PNN-interacting serine/arginine-rich protein
chr8_-_25707421 1.26 ENSDART00000184404
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ga
chr3_-_25369557 1.24 ENSDART00000055491
SMAD specific E3 ubiquitin protein ligase 2
chr2_-_7246848 1.19 ENSDART00000146434
zgc:153115
chr19_-_72398 1.13 ENSDART00000165587
DnaJ (Hsp40) homolog, subfamily C, member 8
chr6_-_9581949 1.13 ENSDART00000144335
cytochrome P450, family 27, subfamily C, polypeptide 1
chr14_-_16476863 1.12 ENSDART00000089021
calnexin
chr1_+_39859782 1.10 ENSDART00000149984
interferon regulatory factor 2a
chr22_-_11520405 1.07 ENSDART00000063157
solute carrier family 26 (anion exchanger), member 11
chr5_-_71995108 1.02 ENSDART00000124587
family with sequence similarity 78, member Ab
chr11_-_17755444 1.00 ENSDART00000154627
EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
chr10_+_45148167 0.99 ENSDART00000172621
oxoglutarate (alpha-ketoglutarate) dehydrogenase b (lipoamide)
chr4_+_15983541 0.99 ENSDART00000043660
coatomer protein complex, subunit gamma 2
chr5_+_62009930 0.96 ENSDART00000082872
A kinase (PRKA) anchor protein 10
chr19_-_24443867 0.88 ENSDART00000163763
ENSDART00000043133
thrombospondin 3b
chr23_+_36308717 0.88 ENSDART00000131711
heterogeneous nuclear ribonucleoprotein A1b
chr12_+_20699534 0.86 ENSDART00000131883
si:ch211-119c20.2
chr3_-_3372259 0.84 ENSDART00000140482
si:dkey-46g23.1
chr5_+_24059598 0.79 ENSDART00000051547
GABA(A) receptor-associated protein a
chr25_-_8201983 0.75 ENSDART00000006579
serum amyloid A-like 1
chr3_-_31086770 0.74 ENSDART00000103421
zgc:153292
chr5_+_62009765 0.73 ENSDART00000134335
A kinase (PRKA) anchor protein 10
chr7_+_17937922 0.67 ENSDART00000147189
metastasis associated 1 family, member 2
chr22_+_9922301 0.67 ENSDART00000105924
bloody fingers
chr20_+_44498056 0.67 ENSDART00000023763
WD repeat and coiled coil containing
chr2_-_183992 0.65 ENSDART00000126704
ENSDART00000191283
ENSDART00000034783
zgc:113518
chr2_+_4146606 0.63 ENSDART00000171170
mindbomb E3 ubiquitin protein ligase 1
chr6_-_141564 0.60 ENSDART00000151245
ENSDART00000063876
sphingosine-1-phosphate receptor 5b
chr25_-_225964 0.57 ENSDART00000193424

chr2_-_56348727 0.53 ENSDART00000060745
ubiquitin A-52 residue ribosomal protein fusion product 1
chr8_-_17184482 0.53 ENSDART00000025803
polymerase (DNA directed), alpha 2
chr22_+_11520249 0.52 ENSDART00000063147
N-sulfoglucosamine sulfohydrolase (sulfamidase)
chr17_-_27382826 0.52 ENSDART00000186657
ENSDART00000155986
ENSDART00000191060
ENSDART00000077608
si:ch1073-358c10.1
chr20_-_14012859 0.51 ENSDART00000152429
si:ch211-22i13.2
chr4_+_359970 0.47 ENSDART00000139832
transmembrane protein 181
chr17_+_37310663 0.43 ENSDART00000157122
ELM2 and Myb/SANT-like domain containing 1b
chr15_-_9321921 0.39 ENSDART00000159676
ENSDART00000033411
trafficking protein particle complex 4
chr16_-_7228276 0.37 ENSDART00000149030
5'-nucleotidase, cytosolic IIIA
chr24_+_24064562 0.37 ENSDART00000144394
zgc:112408
chr22_+_11144153 0.35 ENSDART00000047442
BCL6 corepressor
chr12_-_3978306 0.35 ENSDART00000149473
ENSDART00000114857
protein phosphatase 4, catalytic subunit b
chr15_+_24005289 0.31 ENSDART00000088648
myosin XVIIIAb
chr19_+_2546775 0.30 ENSDART00000148527
ENSDART00000097528
sp4 transcription factor
chr10_+_45148005 0.29 ENSDART00000182501
oxoglutarate (alpha-ketoglutarate) dehydrogenase b (lipoamide)
chr21_-_43992027 0.26 ENSDART00000188612
caudal type homeobox 1 b
chr7_+_17938128 0.22 ENSDART00000141044
metastasis associated 1 family, member 2
chr14_-_42231293 0.11 ENSDART00000185486

chr21_+_11923701 0.10 ENSDART00000109292
ubiquitin associated protein 2a
chr15_-_31067589 0.10 ENSDART00000060157
lectin, galactoside-binding, soluble, 9 (galectin 9)-like 3
chr1_+_16397063 0.10 ENSDART00000159794
mitochondrial calcium uptake family, member 3a
chr13_+_45524475 0.06 ENSDART00000074567
ENSDART00000019113
macoilin 1b
chr18_-_50523399 0.03 ENSDART00000033591
CD276 molecule
chr18_+_16986495 0.02 ENSDART00000147377
si:ch211-218c6.8

Network of associatons between targets according to the STRING database.

First level regulatory network of runx3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.6 GO:0048618 post-embryonic foregut morphogenesis(GO:0048618)
0.6 3.0 GO:0010482 epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.5 1.4 GO:0009162 deoxyribonucleoside monophosphate metabolic process(GO:0009162)
0.4 3.0 GO:0016266 O-glycan processing(GO:0016266)
0.4 4.4 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.4 2.5 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.2 0.6 GO:0003408 optic cup formation involved in camera-type eye development(GO:0003408) spinal cord association neuron specification(GO:0021519)
0.2 1.2 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.2 2.3 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.2 1.4 GO:0060221 retinal rod cell differentiation(GO:0060221)
0.2 4.2 GO:0018149 peptide cross-linking(GO:0018149)
0.2 1.8 GO:0044030 regulation of DNA methylation(GO:0044030)
0.1 7.1 GO:0043297 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.1 2.9 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.1 1.9 GO:0045445 myoblast differentiation(GO:0045445)
0.1 1.8 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1 4.9 GO:0071277 cellular response to calcium ion(GO:0071277)
0.1 1.6 GO:0010390 histone monoubiquitination(GO:0010390)
0.1 3.9 GO:1902593 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.1 0.8 GO:0035278 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 2.6 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 2.1 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.0 0.8 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 1.1 GO:0008272 sulfate transport(GO:0008272)
0.0 1.0 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 1.3 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.4 GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902253) negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902254)
0.0 1.0 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 1.6 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 1.1 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.0 0.3 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.0 0.5 GO:0044273 glycosaminoglycan catabolic process(GO:0006027) sulfur compound catabolic process(GO:0044273)
0.0 1.7 GO:0045089 positive regulation of innate immune response(GO:0045089)
0.0 1.7 GO:0030098 lymphocyte differentiation(GO:0030098)
0.0 3.0 GO:0006338 chromatin remodeling(GO:0006338)
0.0 0.1 GO:0035739 negative regulation of interferon-gamma production(GO:0032689) CD4-positive, alpha-beta T cell activation(GO:0035710) CD4-positive, alpha-beta T cell proliferation(GO:0035739) regulation of CD4-positive, alpha-beta T cell activation(GO:2000514) negative regulation of CD4-positive, alpha-beta T cell activation(GO:2000515) regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000561) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.0 1.3 GO:1902668 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 2.6 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 0.5 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.9 GO:0016575 histone deacetylation(GO:0016575)
0.0 0.3 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 3.2 GO:0000122 negative regulation of transcription from RNA polymerase II promoter(GO:0000122)
0.0 0.1 GO:0023041 neuronal signal transduction(GO:0023041)
0.0 0.9 GO:0031018 endocrine pancreas development(GO:0031018)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 1.3 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.1 0.5 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.1 1.0 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 6.5 GO:0005882 intermediate filament(GO:0005882)
0.1 12.9 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 7.1 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 2.5 GO:0016592 mediator complex(GO:0016592)
0.0 1.8 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.4 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.8 GO:0000421 autophagosome membrane(GO:0000421)
0.0 1.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.3 GO:0048786 presynaptic active zone(GO:0048786)
0.0 1.2 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 4.4 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 14.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.4 3.0 GO:0035252 UDP-xylosyltransferase activity(GO:0035252)
0.3 2.6 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.2 4.2 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.2 4.1 GO:0050321 tau-protein kinase activity(GO:0050321)
0.2 1.0 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.2 1.3 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.2 3.0 GO:0070122 isopeptidase activity(GO:0070122)
0.1 1.1 GO:0001972 retinoic acid binding(GO:0001972)
0.1 1.7 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 2.5 GO:0005112 Notch binding(GO:0005112)
0.1 4.9 GO:0005347 ATP transmembrane transporter activity(GO:0005347)
0.1 0.6 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 1.1 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 1.4 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.8 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.5 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0 1.8 GO:0019843 rRNA binding(GO:0019843)
0.0 0.9 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.5 GO:0031386 protein tag(GO:0031386)
0.0 2.0 GO:0031072 heat shock protein binding(GO:0031072)
0.0 1.4 GO:0019239 deaminase activity(GO:0019239)
0.0 0.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 1.8 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.0 1.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 1.4 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 2.1 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.0 0.4 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 1.1 GO:0051082 unfolded protein binding(GO:0051082)
0.0 10.4 GO:0005198 structural molecule activity(GO:0005198)
0.0 2.9 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 6.9 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 4.5 GO:0000989 transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712)
0.0 0.1 GO:0016936 galactoside binding(GO:0016936)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 1.8 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.2 PID BMP PATHWAY BMP receptor signaling
0.0 0.4 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.4 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.9 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.6 PID NOTCH PATHWAY Notch signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.8 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 3.0 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.1 0.5 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 3.2 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.1 1.2 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 1.4 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.1 1.1 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 6.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 0.5 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.1 6.0 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.5 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.6 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 1.8 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation