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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for rx1+rx2

Z-value: 0.54

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Transcription factors associated with rx1+rx2

Gene Symbol Gene ID Gene Info
rx2
ENSDARG00000040321 retinal homeobox gene 2
rx1
ENSDARG00000071684 retinal homeobox gene 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
rx1dr11_v1_chr22_-_5006119_50061190.232.4e-02Click!
rx2dr11_v1_chr2_-_55861351_55861351-0.037.5e-01Click!

Activity profile of rx1+rx2 motif

Sorted Z-values of rx1+rx2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_-_5598958 6.01 ENSDART00000161538
cyp1a
cytochrome P450, family 1, subfamily A
chr20_+_43925266 5.99 ENSDART00000037379
clic5b
chloride intracellular channel 5b
chr4_-_9891874 4.95 ENSDART00000067193
adm2a
adrenomedullin 2a
chr16_+_23984179 4.43 ENSDART00000175879
apoc2
apolipoprotein C-II
chr21_+_6751405 4.42 ENSDART00000037265
ENSDART00000146371
olfm1b
olfactomedin 1b
chr21_+_6751760 4.36 ENSDART00000135914
olfm1b
olfactomedin 1b
chr7_+_54642005 4.19 ENSDART00000171864
fgf19
fibroblast growth factor 19
chr7_+_6652967 3.97 ENSDART00000102681
pnp5a
purine nucleoside phosphorylase 5a
chr15_-_5815006 3.82 ENSDART00000102459
rbp2a
retinol binding protein 2a, cellular
chr14_-_14659023 2.59 ENSDART00000170355
ENSDART00000159888
ENSDART00000172241
nsdhl
NAD(P) dependent steroid dehydrogenase-like
chr10_-_34002185 2.38 ENSDART00000046599
zar1l
zygote arrest 1-like
chr5_+_37903790 2.25 ENSDART00000162470
tmprss4b
transmembrane protease, serine 4b
chr18_-_40708537 1.94 ENSDART00000077577
si:ch211-132b12.8
si:ch211-132b12.8
chr6_+_40922572 1.66 ENSDART00000133599
ENSDART00000002728
ENSDART00000145153
eif4enif1
eukaryotic translation initiation factor 4E nuclear import factor 1
chr4_-_16124417 1.50 ENSDART00000128079
ENSDART00000077664
atp2b1a
ATPase plasma membrane Ca2+ transporting 1a
chr2_+_6255434 1.42 ENSDART00000139429
zp3b
zona pellucida glycoprotein 3b
chr4_-_56954002 1.38 ENSDART00000160934
si:dkey-269o24.1
si:dkey-269o24.1
chr17_+_24821627 1.22 ENSDART00000112389
wdr43
WD repeat domain 43
chr3_-_23407720 1.09 ENSDART00000155658
rapgefl1
Rap guanine nucleotide exchange factor (GEF)-like 1
chr4_+_11723852 1.05 ENSDART00000028820
mkln1
muskelin 1, intracellular mediator containing kelch motifs
chr15_-_19051152 1.03 ENSDART00000186453
arhgap32a
Rho GTPase activating protein 32a
chr21_+_45223194 0.94 ENSDART00000150902
si:ch73-269m14.3
si:ch73-269m14.3
chr13_-_36663358 0.93 ENSDART00000085319
sos2
son of sevenless homolog 2 (Drosophila)
chr4_+_9467049 0.89 ENSDART00000012659
zgc:55888
zgc:55888
chr11_-_39118882 0.89 ENSDART00000113185
ENSDART00000156526
ap5b1
adaptor-related protein complex 5, beta 1 subunit
chr16_-_31351419 0.83 ENSDART00000178298
ENSDART00000018091
mroh1
maestro heat-like repeat family member 1
chr17_+_24318753 0.81 ENSDART00000064083
otx1
orthodenticle homeobox 1
chr16_-_31622777 0.79 ENSDART00000137311
ENSDART00000002930
phf20l1
PHD finger protein 20 like 1
chr21_-_45188233 0.76 ENSDART00000130880
si:ch73-269m14.2
si:ch73-269m14.2
chr24_-_29586082 0.73 ENSDART00000136763
vav3a
vav 3 guanine nucleotide exchange factor a
chr17_-_53329704 0.68 ENSDART00000193895
exd1
exonuclease 3'-5' domain containing 1
chr22_+_7738966 0.67 ENSDART00000147073
si:ch73-44m9.5
si:ch73-44m9.5
chr9_-_52962521 0.66 ENSDART00000170419
CU855885.1

chr6_+_36839509 0.64 ENSDART00000190605
ENSDART00000104160
zgc:110788
zgc:110788
chr8_+_7801060 0.64 ENSDART00000161618
tfe3a
transcription factor binding to IGHM enhancer 3a
chr6_+_57541776 0.61 ENSDART00000157330
necab3
N-terminal EF-hand calcium binding protein 3
chr20_+_29209767 0.60 ENSDART00000141252
katnbl1
katanin p80 subunit B-like 1
chr17_+_22587356 0.60 ENSDART00000157328
birc6
baculoviral IAP repeat containing 6
chr20_+_29209926 0.59 ENSDART00000152949
ENSDART00000153016
katnbl1
katanin p80 subunit B-like 1
chr9_-_11676491 0.57 ENSDART00000022358
zc3h15
zinc finger CCCH-type containing 15
chr15_+_5360407 0.57 ENSDART00000110420
or112-1
odorant receptor, family A, subfamily 112, member 1
chr11_-_16152400 0.56 ENSDART00000123665
arpc4l
actin related protein 2/3 complex, subunit 4, like
chr16_-_13818061 0.55 ENSDART00000132982
ENSDART00000144856
leng9
leukocyte receptor cluster (LRC) member 9
chr5_-_25733745 0.52 ENSDART00000051566
zgc:101016
zgc:101016
chr8_-_25034411 0.50 ENSDART00000135973
nfyal
nuclear transcription factor Y, alpha, like
chr17_+_3379673 0.48 ENSDART00000176354
sntg2
syntrophin, gamma 2
chr8_-_50888806 0.47 ENSDART00000053750
acsl2
acyl-CoA synthetase long chain family member 2
chr1_+_44127292 0.47 ENSDART00000160542
cabp2a
calcium binding protein 2a
chr7_-_51727760 0.47 ENSDART00000174180
hdac8
histone deacetylase 8
chr10_+_35358675 0.44 ENSDART00000193263
si:dkey-259j3.5
si:dkey-259j3.5
chr17_+_15983557 0.44 ENSDART00000190806
clmn
calmin
chr25_+_30131055 0.43 ENSDART00000152705
api5
apoptosis inhibitor 5
chr1_-_44701313 0.43 ENSDART00000193926
si:dkey-28b4.8
si:dkey-28b4.8
chr4_+_47636303 0.43 ENSDART00000167272
ENSDART00000166961
BX324142.1

chr7_+_26173751 0.40 ENSDART00000065131
si:ch211-196f2.7
si:ch211-196f2.7
chr23_+_12134839 0.39 ENSDART00000128551
ENSDART00000141204
ttll9
tubulin tyrosine ligase-like family, member 9
chr3_-_53533128 0.38 ENSDART00000183591
notch3
notch 3
chr7_+_34620418 0.37 ENSDART00000081338
slc9a5
solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
chr6_-_40922971 0.37 ENSDART00000155363
sfi1
SFI1 centrin binding protein
chr7_+_46368520 0.37 ENSDART00000192821
znf536
zinc finger protein 536
chr8_-_12264486 0.36 ENSDART00000091612
ENSDART00000135812
dab2ipa
DAB2 interacting protein a
chr11_+_7264457 0.36 ENSDART00000154182
reep6
receptor accessory protein 6
chr14_-_33824329 0.35 ENSDART00000189271
ENSDART00000180458
vimr2
vimentin-related 2
chr22_+_23359369 0.35 ENSDART00000170886
dennd1b
DENN/MADD domain containing 1B
chr8_-_39822917 0.35 ENSDART00000067843
zgc:162025
zgc:162025
chr16_-_25568512 0.33 ENSDART00000149411
atxn1b
ataxin 1b
chr19_+_5480327 0.32 ENSDART00000148794
jupb
junction plakoglobin b
chr24_+_38301080 0.32 ENSDART00000105672
mybpc2b
myosin binding protein C, fast type b
chr21_-_30082414 0.31 ENSDART00000157307
ENSDART00000155188
ccnjl
cyclin J-like
chr12_-_41684729 0.30 ENSDART00000184461
jakmip3
Janus kinase and microtubule interacting protein 3
chr9_+_21165484 0.28 ENSDART00000177286
si:rp71-68n21.9
si:rp71-68n21.9
chr21_-_2341937 0.28 ENSDART00000158459
zgc:193790
zgc:193790
chr1_-_17715493 0.27 ENSDART00000133027
si:dkey-256e7.8
si:dkey-256e7.8
chr24_-_25144441 0.27 ENSDART00000152104
phldb2b
pleckstrin homology-like domain, family B, member 2b
chr24_-_31425799 0.26 ENSDART00000157998
cngb3.1
cyclic nucleotide gated channel beta 3, tandem duplicate 1
chr25_+_20715950 0.24 ENSDART00000180223
ergic2
ERGIC and golgi 2
chr11_-_21528056 0.24 ENSDART00000181626
srgap2
SLIT-ROBO Rho GTPase activating protein 2
chr14_+_21820034 0.24 ENSDART00000122739
ctbp1
C-terminal binding protein 1
chr24_-_18809433 0.24 ENSDART00000152009
arfgef1
ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
chr20_+_29209615 0.22 ENSDART00000062350
katnbl1
katanin p80 subunit B-like 1
chr8_+_18011522 0.22 ENSDART00000136756
ssbp3b
single stranded DNA binding protein 3b
chr5_+_58550795 0.21 ENSDART00000192282
pou2f3
POU class 2 homeobox 3
chr1_+_35985813 0.20 ENSDART00000179634
ENSDART00000139636
ENSDART00000175902
zgc:152968
zgc:152968
chr9_+_45493341 0.19 ENSDART00000145616
adarb1b
adenosine deaminase, RNA-specific, B1b
chr9_-_34937025 0.19 ENSDART00000137888
cdc16
cell division cycle 16 homolog (S. cerevisiae)
chr15_-_33925851 0.17 ENSDART00000187807
ENSDART00000187780
mag
myelin associated glycoprotein
chr11_+_16152316 0.16 ENSDART00000081054
tada3l
transcriptional adaptor 3 (NGG1 homolog, yeast)-like
chr23_-_45897900 0.15 ENSDART00000149263
ftr92
finTRIM family, member 92
chr22_+_19407531 0.15 ENSDART00000141060
si:dkey-78l4.2
si:dkey-78l4.2
chr2_+_50608099 0.14 ENSDART00000185805
ENSDART00000111135
neurod6b
neuronal differentiation 6b
chr25_+_34938317 0.14 ENSDART00000042678
vps4a
vacuolar protein sorting 4a homolog A (S. cerevisiae)
chr22_-_20011476 0.14 ENSDART00000093312
ENSDART00000093310
celf5a
cugbp, Elav-like family member 5a
chr3_+_17537352 0.12 ENSDART00000104549
hcrt
hypocretin (orexin) neuropeptide precursor
chr6_+_7421898 0.11 ENSDART00000043946
ccdc65
coiled-coil domain containing 65
chr4_-_4387012 0.11 ENSDART00000191836
CU468826.3
Danio rerio U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1-like (LOC100331497), mRNA.
chr22_-_20924564 0.11 ENSDART00000100642
ENSDART00000032770
ell
elongation factor RNA polymerase II
chr15_-_14552101 0.10 ENSDART00000171169
numbl
numb homolog (Drosophila)-like
chr8_+_16025554 0.09 ENSDART00000110171
elavl4
ELAV like neuron-specific RNA binding protein 4
chr20_-_13774826 0.08 ENSDART00000063831
opn8c
opsin 8, group member c
chr22_+_5123479 0.08 ENSDART00000111822
ENSDART00000081910
loxl5a
lysyl oxidase-like 5a
chr4_+_306036 0.08 ENSDART00000103659
msgn1
mesogenin 1
chr4_-_61691066 0.08 ENSDART00000159114
znf1129
zinc finger protein 1129
chr8_+_18010978 0.06 ENSDART00000039887
ENSDART00000144532
ssbp3b
single stranded DNA binding protein 3b
chr14_+_901847 0.06 ENSDART00000166991
si:ch73-208h1.2
si:ch73-208h1.2
chr8_+_28695914 0.04 ENSDART00000033386
ocstamp
osteoclast stimulatory transmembrane protein
chr16_-_27677930 0.03 ENSDART00000145991
tbrg4
transforming growth factor beta regulator 4
chr11_+_2855430 0.03 ENSDART00000172837
kif21b
kinesin family member 21B
chr20_-_37813863 0.02 ENSDART00000147529
batf3
basic leucine zipper transcription factor, ATF-like 3
chr8_+_18010568 0.02 ENSDART00000121984
ssbp3b
single stranded DNA binding protein 3b
chr16_-_32837806 0.02 ENSDART00000003997
MCHR2
si:dkey-165n16.5
chr14_-_4170654 0.01 ENSDART00000188347
si:dkey-185e18.7
si:dkey-185e18.7
chr12_+_47698356 0.01 ENSDART00000112010
lzts2b
leucine zipper, putative tumor suppressor 2b
chr5_+_32260502 0.01 ENSDART00000149020
si:ch211-158m24.12
si:ch211-158m24.12
chr23_+_16638639 0.01 ENSDART00000143545
snphb
syntaphilin b

Network of associatons between targets according to the STRING database.

First level regulatory network of rx1+rx2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:0034505 tooth mineralization(GO:0034505)
0.2 4.4 GO:0042953 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.1 0.4 GO:0098725 somatic stem cell population maintenance(GO:0035019) symmetric cell division(GO:0098725)
0.1 4.2 GO:0048665 neuron fate specification(GO:0048665)
0.1 1.4 GO:0060046 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.1 2.6 GO:0001878 response to yeast(GO:0001878)
0.1 0.3 GO:0002159 desmosome assembly(GO:0002159)
0.1 6.0 GO:0007605 sensory perception of sound(GO:0007605)
0.1 0.5 GO:0070933 histone H4 deacetylation(GO:0070933)
0.1 0.3 GO:0097065 anterior head development(GO:0097065)
0.1 5.8 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 0.3 GO:0042983 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.0 0.6 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 0.2 GO:2001223 negative regulation of neuron migration(GO:2001223)
0.0 0.8 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.0 0.4 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948) reelin-mediated signaling pathway(GO:0038026)
0.0 0.4 GO:0097369 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.7 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.1 GO:0042755 eating behavior(GO:0042755)
0.0 0.1 GO:0048341 paraxial mesoderm morphogenesis(GO:0048340) paraxial mesoderm formation(GO:0048341)
0.0 0.4 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.5 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.1 GO:0042795 snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.2 GO:0006382 adenosine to inosine editing(GO:0006382)
0.0 0.2 GO:1902101 positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.0 0.1 GO:0003352 regulation of cilium movement(GO:0003352)
0.0 1.7 GO:0017148 negative regulation of translation(GO:0017148)
0.0 0.6 GO:0032465 regulation of cytokinesis(GO:0032465)
0.0 1.2 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 3.4 GO:0009116 nucleoside metabolic process(GO:0009116)
0.0 0.4 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.4 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.1 1.0 GO:0001650 fibrillar center(GO:0001650)
0.1 0.7 GO:1990923 PET complex(GO:1990923)
0.1 6.0 GO:0034707 chloride channel complex(GO:0034707)
0.1 0.8 GO:0044545 NSL complex(GO:0044545)
0.0 0.5 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.9 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.0 0.5 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.4 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.3 GO:0030057 desmosome(GO:0030057)
0.0 0.4 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 0.3 GO:0045180 basal cortex(GO:0045180)
0.0 0.2 GO:0045335 dendritic spine head(GO:0044327) phagocytic vesicle(GO:0045335)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 6.0 GO:0070330 aromatase activity(GO:0070330)
0.4 4.0 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.3 2.6 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.1 4.2 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 1.4 GO:0035804 structural constituent of egg coat(GO:0035804)
0.1 1.9 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 6.0 GO:0005254 chloride channel activity(GO:0005254)
0.0 0.5 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.0 0.3 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.4 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 2.3 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.5 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 5.1 GO:0005179 hormone activity(GO:0005179)
0.0 0.4 GO:0070740 protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.0 0.3 GO:0005221 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 1.7 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.2 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.6 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.4 GO:0005112 Notch binding(GO:0005112)
0.0 0.7 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.0 0.2 GO:0031267 small GTPase binding(GO:0031267)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.1 4.2 PID FGF PATHWAY FGF signaling pathway
0.0 0.6 PID NOTCH PATHWAY Notch signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.2 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.4 4.4 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 2.6 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 0.9 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.4 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.5 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription