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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for scrt1a+scrt1b+scrt2

Z-value: 1.13

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Transcription factors associated with scrt1a+scrt1b+scrt2

Gene Symbol Gene ID Gene Info
ENSDARG00000040214 scratch family zinc finger 1b
ENSDARG00000056175 scratch family zinc finger 2
ENSDARG00000100821 scratch family zinc finger 1a
ENSDARG00000110984 scratch family zinc finger 1b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
scrt1bdr11_v1_chr16_-_31188715_31188715-0.886.9e-31Click!
scrt1adr11_v1_chr19_+_1184878_1184878-0.888.7e-31Click!
scrt2dr11_v1_chr8_+_28527776_28527776-0.861.9e-28Click!

Activity profile of scrt1a+scrt1b+scrt2 motif

Sorted Z-values of scrt1a+scrt1b+scrt2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr13_+_8840772 21.15 ENSDART00000059321
epithelial cell adhesion molecule
chr19_+_7636941 16.10 ENSDART00000081611
ENSDART00000163805
ENSDART00000112404
cingulin b
chr10_-_41352502 12.70 ENSDART00000052971
ENSDART00000128156
RAB11 family interacting protein 1 (class I) b
chr16_-_39570832 12.42 ENSDART00000039832
transforming growth factor beta receptor 2b
chr21_-_11646878 11.16 ENSDART00000162426
ENSDART00000135937
ENSDART00000131448
ENSDART00000148097
ENSDART00000133443
calpastatin
chr15_+_3284684 10.84 ENSDART00000179778
forkhead box O1 a
chr20_+_40150612 9.78 ENSDART00000143680
ENSDART00000109681
ENSDART00000101041
ENSDART00000121818
triadin
chr10_+_9550419 9.48 ENSDART00000064977
si:ch211-243g18.2
chr6_-_52675630 9.44 ENSDART00000083830
syndecan 4
chr10_+_31809226 9.25 ENSDART00000087898
forkhead box O1 b
chr7_+_49664174 9.12 ENSDART00000137059
ENSDART00000131210
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7b
chr24_-_21903360 8.89 ENSDART00000091252
spermatogenesis associated 13
chr16_+_34111919 8.75 ENSDART00000134037
ENSDART00000006061
ENSDART00000140552
transcription elongation factor A (SII), 3
chr20_+_45853154 8.72 ENSDART00000181109

chr14_+_35424539 8.62 ENSDART00000171809
ENSDART00000162185
synaptotagmin-like 4
chr3_+_42923275 8.54 ENSDART00000168228
transmembrane protein 184a
chr19_+_31183495 8.48 ENSDART00000088618
mesenchyme homeobox 2b
chr24_-_21903588 8.17 ENSDART00000180991
spermatogenesis associated 13
chr2_+_9560740 7.77 ENSDART00000003465
GIPC PDZ domain containing family, member 2
chr10_+_17776981 7.74 ENSDART00000141693
chemokine (C-C motif) ligand 19b
chr16_-_32975951 7.49 ENSDART00000101969
ENSDART00000175149
malic enzyme 1, NADP(+)-dependent, cytosolic
chr1_+_53377432 7.29 ENSDART00000177581
uncoupling protein 1
chr3_+_34846201 7.26 ENSDART00000055263
integrin, alpha 3a
chr4_-_8040436 7.23 ENSDART00000113033
si:ch211-240l19.6
chr23_+_36083529 7.19 ENSDART00000053295
ENSDART00000130260
homeobox C10a
chr10_+_187760 7.12 ENSDART00000161007
ENSDART00000160651
v-ets avian erythroblastosis virus E26 oncogene homolog 2
chr7_+_61184551 7.07 ENSDART00000190788
zgc:194930
chr23_+_37579107 7.05 ENSDART00000169376
pleckstrin homology domain containing, family G (with RhoGef domain) member 5b
chr3_+_59851537 6.96 ENSDART00000180997

chr8_-_1051438 6.91 ENSDART00000067093
ENSDART00000170737
SET and MYND domain containing 1b
chr5_+_27525477 6.78 ENSDART00000051491
secreted frizzled-related protein 1a
chr15_-_41245962 6.56 ENSDART00000155359
single-pass membrane protein with coiled-coil domains 4
chr19_-_3303995 6.20 ENSDART00000105150
si:ch211-133n4.9
chr11_+_21076872 6.14 ENSDART00000155521
proline/arginine-rich end leucine-rich repeat protein
chr8_+_11425048 6.06 ENSDART00000018739
tight junction protein 2b (zona occludens 2)
chr22_+_26600834 5.87 ENSDART00000157411
adenylate cyclase 9
chr23_-_32157865 5.85 ENSDART00000000876
nuclear receptor subfamily 4, group A, member 1
chr10_-_13396720 5.81 ENSDART00000030976
interleukin 11 receptor, alpha
chr4_+_2228754 5.79 ENSDART00000166058
cytidine monophospho-N-acetylneuraminic acid hydroxylase
chr20_+_34512130 5.66 ENSDART00000131637
paired related homeobox 1b
chr13_-_28688104 5.63 ENSDART00000133827
polycomb group ring finger 6
chr17_-_5583345 5.62 ENSDART00000035944
chloride intracellular channel 5a
chr20_+_21583639 5.49 ENSDART00000131069
estrogen receptor 2a
chr2_+_2470687 5.29 ENSDART00000184024
ENSDART00000061955
myosin, light chain 13
chr17_+_34186632 5.28 ENSDART00000014306
membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5)
chr19_+_24575077 5.26 ENSDART00000167469
si:dkeyp-92c9.4
chr17_+_23462972 5.08 ENSDART00000112959
ENSDART00000192168
ankyrin repeat domain 1a (cardiac muscle)
chr17_-_2690083 5.04 ENSDART00000135374
protein tyrosine phosphatase, non-receptor type 21
chr17_-_6508406 5.04 ENSDART00000002778
DnaJ (Hsp40) homolog, subfamily C, member 5 gamma b
chr13_+_24584401 4.94 ENSDART00000057599
fucose mutarotase
chr13_+_25486608 4.88 ENSDART00000057689
BCL2 associated athanogene 3
chr4_-_78026285 4.87 ENSDART00000168273
chaperonin containing TCP1 subunit 2
chr25_-_29074064 4.85 ENSDART00000165603
AT rich interactive domain 3B (BRIGHT-like)
chr21_-_9562272 4.82 ENSDART00000162225
ENSDART00000163874
ENSDART00000168173
protein tyrosine phosphatase, non-receptor type 13
chr3_+_53240562 4.68 ENSDART00000031234
syntaxin binding protein 2
chr18_+_38191346 4.67 ENSDART00000052703
nucleobindin 2b
chr11_+_6650966 4.61 ENSDART00000131236
si:dkey-246j7.1
chr22_-_6144428 4.52 ENSDART00000106118
si:dkey-19a16.4
chr4_+_8532580 4.47 ENSDART00000162065
wingless-type MMTV integration site family, member 5b
chr17_+_26543690 4.40 ENSDART00000156417
SPARC-like 2
chr23_+_27740788 4.36 ENSDART00000053871
desert hedgehog
chr4_+_16710001 4.21 ENSDART00000035899
plakophilin 2
chr21_-_4849029 4.20 ENSDART00000168930
ENSDART00000151019
notch 1a
chr1_+_23398405 4.17 ENSDART00000102646
ras homolog family member H
chr16_-_17072440 4.13 ENSDART00000002493
ENSDART00000178443
tumor necrosis factor receptor superfamily, member 1a
chr2_-_32247341 4.13 ENSDART00000146452
family with sequence similarity 49, member Ba
chr12_+_13742953 4.05 ENSDART00000152257
protein phosphatase 1, regulatory subunit 16A
chr18_-_6766354 4.02 ENSDART00000132611
adrenomedullin 2b
chr12_-_28818720 3.66 ENSDART00000134453
ENSDART00000141727
proline rich 15-like b
chr23_-_15090782 3.62 ENSDART00000133624
si:ch211-218g4.2
chr11_+_39928828 3.60 ENSDART00000137516
ENSDART00000134082
vesicle-associated membrane protein 3 (cellubrevin)
chr23_+_38245610 3.59 ENSDART00000191386
zinc finger protein 217
chr3_-_30158395 3.58 ENSDART00000103502
si:ch211-152f23.5
chr2_+_25378457 3.47 ENSDART00000089108
fibronectin type III domain containing 3Ba
chr2_-_26476030 3.46 ENSDART00000145262
ENSDART00000132125
acyl-CoA dehydrogenase medium chain
chr15_+_5923851 3.44 ENSDART00000152520
ENSDART00000145827
ENSDART00000121529
SH3 domain binding glutamate-rich protein
chr4_-_8035520 3.44 ENSDART00000146146
si:ch211-240l19.7
chr25_-_13614702 3.43 ENSDART00000165510
ENSDART00000190959
fatty acid 2-hydroxylase
chr12_+_33484458 3.40 ENSDART00000000069
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1a
chr5_-_65782783 3.38 ENSDART00000130888
ENSDART00000050855
notch 1b
chr3_-_34103123 3.35 ENSDART00000180590
immunoglobulin heavy variable 6-1
chr24_+_26742226 3.32 ENSDART00000079721
growth hormone secretagogue receptor b
chr5_-_1047222 3.28 ENSDART00000181112
methyl-CpG binding domain protein 2
chr23_+_27740592 3.27 ENSDART00000137875
desert hedgehog
chr3_-_61494840 3.27 ENSDART00000101957
BAI1-associated protein 2-like 1b
chr11_+_14321113 3.21 ENSDART00000039822
ENSDART00000137347
ENSDART00000132997
polypyrimidine tract binding protein 1b
chr24_+_25913162 3.15 ENSDART00000143099
ENSDART00000184814
mitogen-activated protein kinase kinase kinase 15
chr24_+_13735616 3.13 ENSDART00000184267
musculin (activated B-cell factor-1)
chr22_-_10891213 3.10 ENSDART00000145229
rho/rac guanine nucleotide exchange factor (GEF) 18b
chr3_-_50046004 3.08 ENSDART00000109544
si:ch1073-100f3.2
chr8_-_24970790 3.06 ENSDART00000141267
si:ch211-199o1.2
chr19_+_41520892 3.04 ENSDART00000182218
ENSDART00000115123
CREB regulated transcription coactivator 2
chr5_-_9216758 2.99 ENSDART00000134896
ENSDART00000147000
low-density lipoprotein receptor related-protein 13
chr7_-_52498175 2.95 ENSDART00000129769
cingulin-like 1
chr7_+_22585447 2.87 ENSDART00000149144
cholinergic receptor, nicotinic, beta 1 (muscle) like
chr14_-_46897067 2.82 ENSDART00000058789
quinoid dihydropteridine reductase a
chr17_-_30521043 2.76 ENSDART00000087111
intersectin 2b
chr21_+_3778498 2.69 ENSDART00000139813
torsin family 1
chr23_+_4741543 2.62 ENSDART00000144761
Raf-1 proto-oncogene, serine/threonine kinase a
chr3_+_37574885 2.59 ENSDART00000055225
wingless-type MMTV integration site family, member 9B
chr20_+_34511678 2.57 ENSDART00000061588
paired related homeobox 1b
chr5_+_6796291 2.52 ENSDART00000166868
ENSDART00000165308
malic enzyme 2, NAD(+)-dependent, mitochondrial
chr25_-_3139805 2.50 ENSDART00000166625
eosinophil peroxidase
chr9_-_34300707 2.37 ENSDART00000049805
immunoglobulin-like domain containing receptor 2
chr11_+_7261981 2.37 ENSDART00000130400
ENSDART00000155427
receptor accessory protein 6
chr13_+_13578552 2.36 ENSDART00000101673
forkhead box I2
chr6_+_46309795 2.33 ENSDART00000154817
si:dkeyp-67f1.1
chr7_-_54677143 2.33 ENSDART00000163748
cyclin D1
chr7_+_38898208 2.31 ENSDART00000172251
cAMP responsive element binding protein 3-like 1
chr15_+_15390882 2.25 ENSDART00000062024
carbonic anhydrase IV b
chr9_+_44034990 2.16 ENSDART00000162406
integrin alpha 4
chr25_+_30074947 2.16 ENSDART00000154849
si:ch211-147k10.5
chr17_-_47090440 2.15 ENSDART00000163542

chr7_+_4625915 2.14 ENSDART00000108557
si:ch211-225k7.3
chr2_+_3201345 2.12 ENSDART00000130349
wingless-type MMTV integration site family, member 9A
chr4_-_17803784 2.10 ENSDART00000187195
Spi-2 proto-oncogene
chr19_-_10612774 2.06 ENSDART00000091898
si:dkey-211g8.6
chr4_+_6736746 2.00 ENSDART00000184175
transmembrane protein 168a
chr1_-_21204114 1.96 ENSDART00000141077
si:dkey-253i9.4
chr8_-_13985032 1.88 ENSDART00000140576
insulin-like growth factor 3
chr2_-_10563576 1.82 ENSDART00000185818
ENSDART00000190887
coiled-coil domain containing 18
chr8_+_26034623 1.82 ENSDART00000004521
ENSDART00000142555
ariadne homolog 2 (Drosophila)
chr15_+_20529197 1.81 ENSDART00000060935
ENSDART00000137926
ENSDART00000140087
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr14_+_6423973 1.78 ENSDART00000051556
ATP-binding cassette, sub-family A (ABC1), member 1B
chr8_-_20118549 1.78 ENSDART00000132218
regulatory factor X, 2 (influences HLA class II expression)
chr14_+_29941266 1.74 ENSDART00000112757
family with sequence similarity 149 member A
chr8_+_46939566 1.70 ENSDART00000139422
espin
chr4_-_21466480 1.65 ENSDART00000139962
PRKC, apoptosis, WT1, regulator
chr17_+_47090497 1.58 ENSDART00000169038
ENSDART00000159292
zgc:103755
chr2_+_10766744 1.51 ENSDART00000015379
growth factor independent 1A transcription repressor a
chr20_+_22220988 1.51 ENSDART00000049204
kinase insert domain receptor (a type III receptor tyrosine kinase)
chr20_-_52271015 1.47 ENSDART00000074307
rhophilin, Rho GTPase binding protein 1
chr16_-_45225520 1.46 ENSDART00000158855
FXYD domain containing ion transport regulator 1 (phospholemman)
chr7_-_29292206 1.45 ENSDART00000086753
death-associated protein kinase 2a
chr2_-_10564019 1.43 ENSDART00000132167
coiled-coil domain containing 18
chr8_-_9684872 1.41 ENSDART00000132158
protein tyrosine phosphatase, non-receptor type 18
chr18_+_41820039 1.41 ENSDART00000128345
progesterone receptor
chr15_+_17848590 1.39 ENSDART00000168940
zgc:113279
chr25_-_893464 1.36 ENSDART00000159321
zinc finger protein 609a
chr18_-_10995410 1.33 ENSDART00000136751
tetraspanin 33b
chr7_-_18700364 1.27 ENSDART00000112359
si:ch211-119e14.9
chr2_-_6115389 1.24 ENSDART00000134921
peroxiredoxin 1
chr9_-_33725972 1.21 ENSDART00000028225
monoamine oxidase
chr11_+_27968834 1.17 ENSDART00000147984
alkaline phosphatase, liver/bone/kidney
chr9_+_48415043 1.17 ENSDART00000159930
low density lipoprotein receptor-related protein 2a
chr23_-_6522099 1.16 ENSDART00000092214
ENSDART00000183380
ENSDART00000138020
bone morphogenetic protein 7b
chr7_+_4524059 1.16 ENSDART00000187693
si:dkey-83f18.4
chr20_-_52271262 1.14 ENSDART00000135463
rhophilin, Rho GTPase binding protein 1
chr5_+_44806374 1.12 ENSDART00000184237
cathepsin La
chr21_+_22237964 1.11 ENSDART00000003181
myosin VIIAb
chr6_-_1865323 1.11 ENSDART00000155775
discs, large (Drosophila) homolog-associated protein 4b
chr9_-_21970067 1.09 ENSDART00000009920
LIM domain 7a
chr19_+_1831911 1.09 ENSDART00000166653
protein tyrosine kinase 2aa
chr22_+_26804197 1.08 ENSDART00000135688
si:dkey-44g23.2
chr22_-_23545307 1.04 ENSDART00000166915
crumbs family member 1, photoreceptor morphogenesis associated
chr12_-_4916969 1.03 ENSDART00000161680
interferon phi 4
chr8_+_46939391 1.01 ENSDART00000146631
espin
chr25_-_13614863 0.95 ENSDART00000121859
fatty acid 2-hydroxylase
chr13_-_39159810 0.94 ENSDART00000131508
collagen, type IX, alpha 1b
chr15_+_36309070 0.76 ENSDART00000157034
geminin coiled-coil domain containing
chr2_+_50477779 0.75 ENSDART00000122716

chr9_+_44034790 0.74 ENSDART00000166110
ENSDART00000176954
integrin alpha 4
chr7_-_20836625 0.72 ENSDART00000192566
claudin 15a
chr11_-_42417194 0.70 ENSDART00000191086
ENSDART00000076650
ENSDART00000165903
ENSDART00000104444
sarcolemma associated protein a
chr13_-_8446341 0.69 ENSDART00000080382
endothelial PAS domain protein 1b
chr19_+_10559307 0.67 ENSDART00000151801
upstream transcription factor 2, c-fos interacting
chr13_-_42560662 0.65 ENSDART00000124898

chr24_+_24086491 0.63 ENSDART00000145092
lipase, member Ib
chr3_-_31079186 0.61 ENSDART00000145636
ENSDART00000140569
elongin B
elongin B
chr16_+_14684916 0.61 ENSDART00000138611
collagen, type XIV, alpha 1a
chr21_+_29227224 0.56 ENSDART00000013641
adrenoceptor alpha 1Ba
chr7_-_7823662 0.53 ENSDART00000167652
chemokine (C-X-C motif) ligand 8b, duplicate 3
chr22_-_6362442 0.51 ENSDART00000149907
ENSDART00000106104
zgc:113298
chr22_+_3045495 0.49 ENSDART00000164061

chr16_-_43233509 0.44 ENSDART00000025877
claudin 12
chr7_-_71456117 0.38 ENSDART00000042492
Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
chr11_+_27969045 0.36 ENSDART00000146461
alkaline phosphatase, liver/bone/kidney
chr3_-_56030117 0.35 ENSDART00000113030
ENSDART00000157764
centrosomal protein 112
chr13_-_36844945 0.35 ENSDART00000129562
ENSDART00000150899
ninein (GSK3B interacting protein)
chr5_-_16218777 0.34 ENSDART00000141698
kringle containing transmembrane protein 1
chr16_+_21918503 0.28 ENSDART00000167919
zinc finger protein 687a
chr7_-_41468751 0.26 ENSDART00000150146
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3b
chr2_-_30659222 0.25 ENSDART00000145405
catenin (cadherin-associated protein), delta 2b
chr19_-_45650994 0.19 ENSDART00000163504
trichorhinophalangeal syndrome I
chr10_-_19523752 0.17 ENSDART00000160057
si:ch211-127i16.2
chr23_-_43713757 0.12 ENSDART00000192175
ATP-binding cassette, sub-family E (OABP), member 1

Network of associatons between targets according to the STRING database.

First level regulatory network of scrt1a+scrt1b+scrt2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 9.4 GO:0036445 neuronal stem cell division(GO:0036445) somatic stem cell division(GO:0048103)
1.6 4.9 GO:0010660 negative regulation of muscle cell apoptotic process(GO:0010656) muscle cell apoptotic process(GO:0010657) striated muscle cell apoptotic process(GO:0010658) regulation of muscle cell apoptotic process(GO:0010660) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664)
1.6 11.2 GO:0097341 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
1.5 10.8 GO:0048745 smooth muscle tissue development(GO:0048745)
1.4 4.2 GO:0021531 spinal cord radial glial cell differentiation(GO:0021531)
1.4 4.1 GO:0002544 granuloma formation(GO:0002432) chronic inflammatory response(GO:0002544) regulation of granuloma formation(GO:0002631) regulation of chronic inflammatory response(GO:0002676)
1.3 5.3 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
1.1 7.6 GO:0016539 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
1.0 10.0 GO:0006108 malate metabolic process(GO:0006108)
0.9 7.3 GO:1990845 adaptive thermogenesis(GO:1990845)
0.9 4.5 GO:1904105 regulation of Wnt signaling pathway, calcium modulating pathway(GO:0008591) positive regulation of convergent extension involved in gastrulation(GO:1904105)
0.8 4.9 GO:0006004 fucose metabolic process(GO:0006004)
0.6 5.8 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.6 6.9 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
0.6 3.1 GO:0015709 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) malate transmembrane transport(GO:0071423)
0.6 4.2 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.6 5.8 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.6 3.5 GO:0051791 medium-chain fatty acid metabolic process(GO:0051791) medium-chain fatty acid catabolic process(GO:0051793)
0.5 5.5 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.5 2.7 GO:0071763 nuclear membrane organization(GO:0071763)
0.5 4.7 GO:0032094 response to food(GO:0032094)
0.5 2.3 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.4 3.0 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.4 16.0 GO:0048920 posterior lateral line neuromast primordium migration(GO:0048920)
0.4 2.8 GO:0042438 melanin biosynthetic process(GO:0042438)
0.4 5.6 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.4 5.8 GO:0000186 activation of MAPKK activity(GO:0000186)
0.4 4.1 GO:0097150 neuronal stem cell population maintenance(GO:0097150)
0.4 2.1 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.3 1.6 GO:0031116 positive regulation of microtubule polymerization(GO:0031116)
0.2 8.5 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.2 3.6 GO:0035493 SNARE complex assembly(GO:0035493)
0.2 1.4 GO:0030728 ovulation(GO:0030728)
0.2 2.2 GO:0038203 TORC2 signaling(GO:0038203)
0.2 3.3 GO:0046626 regulation of insulin receptor signaling pathway(GO:0046626)
0.2 7.7 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.2 1.8 GO:0033700 phospholipid efflux(GO:0033700)
0.2 2.7 GO:0034112 positive regulation of homotypic cell-cell adhesion(GO:0034112) positive regulation of T cell activation(GO:0050870) positive regulation of leukocyte cell-cell adhesion(GO:1903039)
0.2 1.7 GO:0043114 regulation of vascular permeability(GO:0043114)
0.2 1.8 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.2 4.2 GO:1902622 regulation of neutrophil migration(GO:1902622)
0.2 1.1 GO:0000706 meiotic DNA double-strand break processing(GO:0000706)
0.2 0.8 GO:1903251 multi-ciliated epithelial cell differentiation(GO:1903251)
0.1 9.1 GO:0006414 translational elongation(GO:0006414)
0.1 6.2 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 12.2 GO:0001945 lymph vessel development(GO:0001945)
0.1 12.4 GO:0007179 transforming growth factor beta receptor signaling pathway(GO:0007179) response to transforming growth factor beta(GO:0071559) cellular response to transforming growth factor beta stimulus(GO:0071560)
0.1 1.2 GO:0042135 neurotransmitter catabolic process(GO:0042135)
0.1 1.2 GO:0070293 renal absorption(GO:0070293)
0.1 1.9 GO:0001556 oocyte maturation(GO:0001556)
0.1 3.4 GO:0055078 sodium ion homeostasis(GO:0055078)
0.1 0.9 GO:0098869 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.1 1.0 GO:0043330 response to exogenous dsRNA(GO:0043330)
0.1 1.1 GO:0007172 signal complex assembly(GO:0007172)
0.1 5.0 GO:0001837 epithelial to mesenchymal transition(GO:0001837)
0.1 7.3 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.1 0.6 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996) positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321) positive regulation of heart rate(GO:0010460)
0.1 10.2 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 0.3 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.1 0.3 GO:0048903 anterior lateral line neuromast hair cell differentiation(GO:0048903)
0.1 4.0 GO:0035304 regulation of protein dephosphorylation(GO:0035304)
0.1 5.9 GO:0009190 cyclic nucleotide biosynthetic process(GO:0009190)
0.1 1.1 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.1 9.1 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.1 3.3 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 1.5 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.1 1.5 GO:0035924 cellular response to vascular endothelial growth factor stimulus(GO:0035924)
0.0 8.5 GO:0061053 somite development(GO:0061053)
0.0 0.5 GO:0036230 granulocyte activation(GO:0036230) neutrophil activation(GO:0042119)
0.0 5.0 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.0 5.4 GO:0006821 chloride transport(GO:0006821)
0.0 2.4 GO:0007492 endoderm development(GO:0007492)
0.0 2.2 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 5.8 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.0 1.2 GO:0060393 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862) regulation of pathway-restricted SMAD protein phosphorylation(GO:0060393) SMAD protein signal transduction(GO:0060395)
0.0 1.8 GO:1901800 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.0 1.0 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.3 GO:0032986 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 9.2 GO:0006887 exocytosis(GO:0006887)
0.0 1.8 GO:0070121 Kupffer's vesicle development(GO:0070121)
0.0 0.7 GO:0048546 digestive tract morphogenesis(GO:0048546)
0.0 0.6 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 8.4 GO:0001525 angiogenesis(GO:0001525)
0.0 0.6 GO:0070831 basement membrane assembly(GO:0070831)
0.0 1.1 GO:0099515 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 1.5 GO:0009612 response to mechanical stimulus(GO:0009612)
0.0 3.1 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.0 3.2 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 2.9 GO:0042391 regulation of membrane potential(GO:0042391)
0.0 4.0 GO:1904888 cranial skeletal system development(GO:1904888)
0.0 5.7 GO:0006897 endocytosis(GO:0006897)
0.0 1.5 GO:0043065 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.0 1.3 GO:0072659 protein localization to plasma membrane(GO:0072659) protein localization to cell periphery(GO:1990778)
0.0 0.2 GO:0060997 dendritic spine morphogenesis(GO:0060997) dendritic spine organization(GO:0097061)
0.0 1.4 GO:0006979 response to oxidative stress(GO:0006979)
0.0 0.6 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 9.8 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.4 4.2 GO:0014704 intercalated disc(GO:0014704)
0.3 6.9 GO:0031430 M band(GO:0031430)
0.2 5.3 GO:0001917 photoreceptor inner segment(GO:0001917)
0.2 2.9 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.2 5.6 GO:0035102 PRC1 complex(GO:0035102)
0.2 10.2 GO:0008305 integrin complex(GO:0008305)
0.2 21.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.2 1.1 GO:0033557 Slx1-Slx4 complex(GO:0033557)
0.2 3.4 GO:0005902 microvillus(GO:0005902)
0.2 3.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.2 17.1 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2 20.2 GO:0016459 myosin complex(GO:0016459)
0.1 2.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 7.8 GO:0031901 early endosome membrane(GO:0031901)
0.1 7.1 GO:0030139 endocytic vesicle(GO:0030139)
0.1 0.6 GO:0030891 VCB complex(GO:0030891)
0.1 9.5 GO:0005882 intermediate filament(GO:0005882)
0.1 2.2 GO:0031932 TORC2 complex(GO:0031932)
0.1 5.4 GO:0034707 chloride channel complex(GO:0034707)
0.1 4.7 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 6.4 GO:0016324 apical plasma membrane(GO:0016324)
0.1 0.6 GO:0005614 interstitial matrix(GO:0005614)
0.1 2.8 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 6.8 GO:0005924 cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925)
0.1 2.4 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.1 0.9 GO:0005581 collagen trimer(GO:0005581)
0.1 3.3 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 3.8 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.6 GO:0035371 microtubule plus-end(GO:0035371)
0.1 4.9 GO:0030018 Z disc(GO:0030018)
0.1 2.7 GO:0030426 growth cone(GO:0030426)
0.1 1.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 4.7 GO:0030141 secretory granule(GO:0030141)
0.0 3.6 GO:0031201 SNARE complex(GO:0031201)
0.0 43.0 GO:0005615 extracellular space(GO:0005615)
0.0 0.3 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 7.3 GO:0043235 receptor complex(GO:0043235)
0.0 3.5 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 8.5 GO:0031966 mitochondrial membrane(GO:0031966)
0.0 9.2 GO:0005739 mitochondrion(GO:0005739)
0.0 0.3 GO:0071564 npBAF complex(GO:0071564)
0.0 1.9 GO:0048471 perinuclear region of cytoplasm(GO:0048471)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 10.0 GO:0004470 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
2.1 12.4 GO:0050431 transforming growth factor beta binding(GO:0050431)
1.9 5.8 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
1.8 7.3 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
1.6 4.9 GO:0042806 fucose binding(GO:0042806)
1.6 11.2 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
1.5 4.4 GO:0080132 fatty acid alpha-hydroxylase activity(GO:0080132)
1.3 5.1 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
1.0 4.0 GO:0017020 myosin phosphatase regulator activity(GO:0017020)
0.8 7.6 GO:0005113 patched binding(GO:0005113)
0.8 4.1 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.8 5.5 GO:1903924 estradiol binding(GO:1903924)
0.7 2.8 GO:0004155 6,7-dihydropteridine reductase activity(GO:0004155) NADH binding(GO:0070404)
0.7 4.2 GO:0019215 intermediate filament binding(GO:0019215)
0.6 3.1 GO:0015140 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140)
0.5 5.8 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.5 4.9 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.4 3.0 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.4 4.8 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.4 1.8 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012) phosphatidylcholine-translocating ATPase activity(GO:0090554) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.3 1.0 GO:0005132 type I interferon receptor binding(GO:0005132)
0.3 8.6 GO:0042043 neurexin family protein binding(GO:0042043)
0.3 6.9 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.3 3.4 GO:0043495 protein anchor(GO:0043495)
0.3 1.4 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.2 1.2 GO:0008131 primary amine oxidase activity(GO:0008131)
0.2 1.9 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.2 3.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.2 3.5 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.2 9.2 GO:0005109 frizzled binding(GO:0005109)
0.2 5.9 GO:0004016 adenylate cyclase activity(GO:0004016)
0.2 6.8 GO:0017147 Wnt-protein binding(GO:0017147)
0.2 8.8 GO:0003746 translation elongation factor activity(GO:0003746)
0.2 1.5 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.2 9.4 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.2 7.7 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.2 4.2 GO:0005112 Notch binding(GO:0005112)
0.1 3.1 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 0.5 GO:0005153 interleukin-8 receptor binding(GO:0005153)
0.1 1.5 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1 0.9 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 2.7 GO:0019894 kinesin binding(GO:0019894)
0.1 2.9 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 1.2 GO:0070700 BMP receptor binding(GO:0070700)
0.1 4.4 GO:0005518 collagen binding(GO:0005518)
0.1 2.2 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 20.2 GO:0003774 motor activity(GO:0003774)
0.1 26.3 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.1 0.6 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.1 3.3 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 5.8 GO:0019838 growth factor binding(GO:0019838)
0.1 0.6 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.1 5.4 GO:0005254 chloride channel activity(GO:0005254)
0.1 1.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 3.6 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 6.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.8 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 2.5 GO:0004601 peroxidase activity(GO:0004601)
0.0 2.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 1.4 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 1.2 GO:0042562 hormone binding(GO:0042562)
0.0 5.0 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 4.2 GO:0019901 protein kinase binding(GO:0019901)
0.0 1.5 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 1.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 2.7 GO:0051015 actin filament binding(GO:0051015)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.1 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.5 9.4 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.4 5.9 PID LPA4 PATHWAY LPA4-mediated signaling events
0.4 15.4 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.3 7.6 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.3 1.4 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.3 5.8 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.3 2.9 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.3 1.5 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.2 4.8 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.2 7.4 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.2 6.1 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 3.6 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 6.9 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.1 3.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.0 PID LKB1 PATHWAY LKB1 signaling events
0.1 2.9 PID CMYB PATHWAY C-MYB transcription factor network
0.0 3.3 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.9 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.0 2.6 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 9.4 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.6 6.1 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.5 5.9 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.5 4.1 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.3 3.3 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.2 3.5 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.2 4.9 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.2 12.3 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 1.5 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 5.8 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.1 7.3 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1 2.3 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 7.5 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.4 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 1.4 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 4.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases