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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for six4a+six4b

Z-value: 0.73

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Transcription factors associated with six4a+six4b

Gene Symbol Gene ID Gene Info
six4a
ENSDARG00000004695 SIX homeobox 4a
six4b
ENSDARG00000031983 SIX homeobox 4b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
six4bdr11_v1_chr20_+_20484827_20484827-0.261.3e-02Click!
six4adr11_v1_chr13_-_31647323_31647323-0.132.0e-01Click!

Activity profile of six4a+six4b motif

Sorted Z-values of six4a+six4b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_10134345 8.61 ENSDART00000100725
ahsg2
alpha-2-HS-glycoprotein 2
chr9_+_8396755 7.48 ENSDART00000043067
zgc:171776
zgc:171776
chr3_-_39152478 6.91 ENSDART00000154550
si:dkeyp-57f11.2
si:dkeyp-57f11.2
chr2_+_24304854 5.60 ENSDART00000078972
fitm1
fat storage-inducing transmembrane protein 1
chr22_+_25236888 5.23 ENSDART00000037286
zgc:172218
zgc:172218
chr22_+_25242322 5.10 ENSDART00000134628
si:ch211-226h8.8
si:ch211-226h8.8
chr1_+_55140970 5.08 ENSDART00000039807
mb
myoglobin
chr24_+_34089977 5.05 ENSDART00000157466
asb10
ankyrin repeat and SOCS box containing 10
chr22_+_25236657 4.64 ENSDART00000138012
zgc:172218
zgc:172218
chr14_-_7128980 4.22 ENSDART00000171311
si:ch73-43g23.1
si:ch73-43g23.1
chr9_+_2041535 3.81 ENSDART00000093187
lnpa
limb and neural patterns a
chr15_-_35126332 3.27 ENSDART00000007636
zgc:55413
zgc:55413
chr8_+_35964482 3.10 ENSDART00000129357
ENSDART00000154953
glt1d1
glycosyltransferase 1 domain containing 1
chr5_-_5831037 2.86 ENSDART00000112856
zmp:0000000846
zmp:0000000846
chr16_-_13818061 2.63 ENSDART00000132982
ENSDART00000144856
leng9
leukocyte receptor cluster (LRC) member 9
chr7_-_41851605 2.61 ENSDART00000142981
mylk3
myosin light chain kinase 3
chr25_-_15214161 2.46 ENSDART00000031499
wt1a
wilms tumor 1a
chr8_+_49149907 2.31 ENSDART00000138746
snpha
syntaphilin a
chr3_-_56896702 2.31 ENSDART00000023265
ush1ga
Usher syndrome 1Ga (autosomal recessive)
chr6_-_3978919 2.18 ENSDART00000167753
slc25a12
solute carrier family 25 (aspartate/glutamate carrier), member 12
chr22_-_36774057 2.17 ENSDART00000125048
acy1
aminoacylase 1
chr20_+_33534038 2.12 ENSDART00000029206
kcnf1a
potassium voltage-gated channel, subfamily F, member 1a
chr19_-_10330778 2.09 ENSDART00000081465
ENSDART00000136653
ENSDART00000171232
ccdc106b
coiled-coil domain containing 106b
chr23_+_45785563 2.05 ENSDART00000186027
CABZ01088036.1

chr7_+_6480212 2.04 ENSDART00000173320
si:cabz01036022.1
si:cabz01036022.1
chr11_+_41560792 2.01 ENSDART00000127292
kcnab2a
potassium voltage-gated channel, shaker-related subfamily, beta member 2 a
chr21_+_34167178 2.00 ENSDART00000158308
trpc5b
transient receptor potential cation channel, subfamily C, member 5b
chr5_+_55221593 1.85 ENSDART00000073638
tmc2a
transmembrane channel-like 2a
chr1_-_7894255 1.85 ENSDART00000167126
ENSDART00000145460
radil
Ras association and DIL domains
chr12_-_18872927 1.82 ENSDART00000187717
shisa8b
shisa family member 8b
chr17_-_1407593 1.82 ENSDART00000157622
ENSDART00000159458
zbtb42
zinc finger and BTB domain containing 42
chr22_-_36774219 1.82 ENSDART00000056151
ENSDART00000168711
acy1
aminoacylase 1
chr6_-_33129312 1.78 ENSDART00000156987
tspan1
tetraspanin 1
chr13_-_39399967 1.78 ENSDART00000190791
ENSDART00000136267
slc35f3b
solute carrier family 35, member F3b
chr6_+_40591149 1.71 ENSDART00000189060
ENSDART00000188298
frs3
fibroblast growth factor receptor substrate 3
chr11_+_583725 1.69 ENSDART00000189415
mkrn2os.2
MKRN2 opposite strand, tandem duplicate 2
chr22_-_209741 1.69 ENSDART00000171954
ora1
olfactory receptor class A related 1
chr2_+_29491314 1.67 ENSDART00000181774
dlgap1a
discs, large (Drosophila) homolog-associated protein 1a
chr3_+_12718100 1.66 ENSDART00000162343
ENSDART00000192425
cyp2k20
cytochrome P450, family 2, subfamily k, polypeptide 20
chr22_+_15310103 1.65 ENSDART00000145849
CU104797.1

chr19_+_770300 1.63 ENSDART00000062518
gstr
glutathione S-transferase rho
chr10_-_32610776 1.61 ENSDART00000017436
mogat2
monoacylglycerol O-acyltransferase 2
chr19_+_31183495 1.58 ENSDART00000088618
meox2b
mesenchyme homeobox 2b
chr6_-_21678263 1.58 ENSDART00000038777
si:dkey-43k4.5
si:dkey-43k4.5
chr1_-_58561963 1.55 ENSDART00000165040
slc27a1b
solute carrier family 27 (fatty acid transporter), member 1b
chr6_+_39085969 1.53 ENSDART00000004240
prss60.1
protease, serine, 60.1
chr2_+_38804223 1.52 ENSDART00000147939
carmil3
capping protein regulator and myosin 1 linker 3
chr23_+_16469530 1.52 ENSDART00000132898
ntsr1
neurotensin receptor 1 (high affinity)
chr3_-_34072446 1.51 ENSDART00000151528
ighv8-2
immunoglobulin heavy variable 8-2
chr2_+_25198648 1.49 ENSDART00000110922
ppp2r3a
protein phosphatase 2, regulatory subunit B'', alpha
chr17_+_5768608 1.47 ENSDART00000157039
rp1l1a
retinitis pigmentosa 1-like 1a
chr11_+_40649412 1.47 ENSDART00000043016
ENSDART00000134560
slc45a1
solute carrier family 45, member 1
chr15_-_37834433 1.46 ENSDART00000189748
si:dkey-238d18.3
si:dkey-238d18.3
chr3_+_39099716 1.44 ENSDART00000083388
tmem98
transmembrane protein 98
chr21_+_21679086 1.44 ENSDART00000146225
or125-5
odorant receptor, family E, subfamily 125, member 5
chr7_-_26306546 1.43 ENSDART00000140817
zgc:77439
zgc:77439
chr8_+_49570884 1.41 ENSDART00000182117
ENSDART00000108613
rasef
RAS and EF-hand domain containing
chr8_+_14058646 1.37 ENSDART00000080852
ugt5e1
UDP glucuronosyltransferase 5 family, polypeptide E1
chr2_-_32558795 1.36 ENSDART00000140026
smarcd3a
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3a
chr23_-_7125494 1.36 ENSDART00000111929
slco4a1
solute carrier organic anion transporter family, member 4A1
chr3_+_311833 1.35 ENSDART00000187375
FP326649.2

chr14_-_2209742 1.31 ENSDART00000054889
pcdh2ab5
protocadherin 2 alpha b 5
chr19_-_18626515 1.29 ENSDART00000160624
rps18
ribosomal protein S18
chr23_-_10831995 1.26 ENSDART00000142533
pdzrn3a
PDZ domain containing RING finger 3a
chr4_-_77332032 1.24 ENSDART00000168628
ENSDART00000172025
slco1f3
solute carrier organic anion transporter family, member 1F3
chr17_-_42213285 1.23 ENSDART00000140549
nkx2.2a
NK2 homeobox 2a
chr12_-_16524727 1.21 ENSDART00000166645
FO704724.1

chr4_-_77506362 1.19 ENSDART00000174387
ENSDART00000181181
CABZ01087415.1

chr4_-_72468168 1.15 ENSDART00000182995
ENSDART00000174067
CR788316.1

chr7_+_73827805 1.12 ENSDART00000109316
zgc:173587
zgc:173587
chr7_-_73852594 1.09 ENSDART00000183194
zgc:165555
zgc:165555
chr1_-_7603734 1.08 ENSDART00000009315
mxb
myxovirus (influenza) resistance B
chr10_-_36682509 1.07 ENSDART00000148093
ENSDART00000063365
dnajb13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr4_-_16345227 1.07 ENSDART00000079521
kera
keratocan
chr19_-_15434813 1.06 ENSDART00000019843
ftr55
finTRIM family, member 55
chr3_-_40955780 1.05 ENSDART00000130130
cyp3c3
cytochrome P450, family 3, subfamily c, polypeptide 3
chr1_-_58562129 1.04 ENSDART00000159070
slc27a1b
solute carrier family 27 (fatty acid transporter), member 1b
chr17_-_42213822 1.03 ENSDART00000187904
ENSDART00000180029
nkx2.2a
NK2 homeobox 2a
chr12_-_31484677 1.01 ENSDART00000066578
tectb
tectorin beta
chr5_+_51079504 1.01 ENSDART00000097466
fam169aa
family with sequence similarity 169, member Aa
chr13_+_3954715 1.00 ENSDART00000182477
ENSDART00000192142
ENSDART00000190962
lrrc73
leucine rich repeat containing 73
chr9_-_34882516 0.97 ENSDART00000011163
asmtl
acetylserotonin O-methyltransferase-like
chr7_-_58130703 0.97 ENSDART00000172082
ank2b
ankyrin 2b, neuronal
chr9_+_48219111 0.95 ENSDART00000111225
ENSDART00000145972
ccdc173
coiled-coil domain containing 173
chr14_-_2318590 0.93 ENSDART00000192735
pcdh2ab8
protocadherin 2 alpha b 8
chr2_-_5404466 0.92 ENSDART00000152907
si:ch1073-184j22.2
si:ch1073-184j22.2
chr3_+_57779673 0.91 ENSDART00000101839
tmc6a
transmembrane channel-like 6a
chr2_+_33335911 0.89 ENSDART00000126135
slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr20_+_22067337 0.86 ENSDART00000152636
clocka
clock circadian regulator a
chr25_-_17528994 0.86 ENSDART00000061712
si:dkey-44k1.5
si:dkey-44k1.5
chr1_-_46632948 0.85 ENSDART00000148893
ENSDART00000053232
cdadc1
cytidine and dCMP deaminase domain containing 1
chr19_-_18626952 0.84 ENSDART00000168004
ENSDART00000162034
ENSDART00000165486
ENSDART00000167971
rps18
ribosomal protein S18
chr7_+_58699900 0.80 ENSDART00000144009
sdr16c5b
short chain dehydrogenase/reductase family 16C, member 5b
chr23_+_27779452 0.78 ENSDART00000134785
kmt2d
lysine (K)-specific methyltransferase 2D
chr22_+_21317597 0.78 ENSDART00000132605
shc2
SHC (Src homology 2 domain containing) transforming protein 2
chr1_+_37752171 0.78 ENSDART00000183247
ENSDART00000189756
ENSDART00000139448
GALNTL6
si:ch211-15e22.3
chr14_+_24042760 0.77 ENSDART00000106096
drd1a
dopamine receptor D1a
chr2_+_50626476 0.76 ENSDART00000018150
neurod6b
neuronal differentiation 6b
chr13_-_14269626 0.75 ENSDART00000079176
gfra4a
GDNF family receptor alpha 4a
chr2_-_30770736 0.73 ENSDART00000131230
rgs20
regulator of G protein signaling 20
chr2_-_4797512 0.72 ENSDART00000160765
tnk2b
tyrosine kinase, non-receptor, 2b
chr21_+_39365920 0.71 ENSDART00000140940
cluhb
clustered mitochondria (cluA/CLU1) homolog b
chr24_-_23839647 0.70 ENSDART00000125190
rrs1
RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
chr17_+_15882533 0.70 ENSDART00000164124
gabrr2a
gamma-aminobutyric acid (GABA) A receptor, rho 2a
chr5_-_43071058 0.67 ENSDART00000165546
si:dkey-245n4.2
si:dkey-245n4.2
chr6_-_35310224 0.66 ENSDART00000148997
nos1apa
nitric oxide synthase 1 (neuronal) adaptor protein a
chr16_+_50755133 0.66 ENSDART00000029283
IGLON5
zgc:110372
chr18_-_12416019 0.65 ENSDART00000144799
si:ch211-1e14.1
si:ch211-1e14.1
chr7_-_41964877 0.65 ENSDART00000092351
ENSDART00000193395
ENSDART00000187947
neto2b
neuropilin (NRP) and tolloid (TLL)-like 2b
chr1_+_1941031 0.61 ENSDART00000110331
PTGFRN
si:ch211-132g1.7
chr17_-_13072334 0.60 ENSDART00000159598
CU469462.1

chr7_+_18176162 0.60 ENSDART00000109171
rce1a
Ras converting CAAX endopeptidase 1a
chr7_+_48297842 0.59 ENSDART00000052123
slc25a44b
solute carrier family 25, member 44 b
chr16_-_46567136 0.59 ENSDART00000159180
si:dkey-152b24.7
si:dkey-152b24.7
chr21_-_36396334 0.59 ENSDART00000183627
mrpl22
mitochondrial ribosomal protein L22
chr8_+_7801060 0.58 ENSDART00000161618
tfe3a
transcription factor binding to IGHM enhancer 3a
chr25_+_19695652 0.57 ENSDART00000104340
mxg
myxovirus (influenza virus) resistance G
chr4_+_288633 0.52 ENSDART00000183304
FO834823.1

chr12_+_23991276 0.52 ENSDART00000153136
psme4b
proteasome activator subunit 4b
chr2_+_30465102 0.50 ENSDART00000188404
neto1
neuropilin (NRP) and tolloid (TLL)-like 1
chr8_-_3346692 0.50 ENSDART00000057874
FUT9 (1 of many)
zgc:103510
chr19_-_6083761 0.49 ENSDART00000151185
ENSDART00000143941
gsk3aa
glycogen synthase kinase 3 alpha a
chr21_-_30714665 0.49 ENSDART00000128011
tnfsf10l3
tumor necrosis factor (ligand) superfamily, member 10 like 3
chr9_+_40874194 0.46 ENSDART00000141548
hibch
3-hydroxyisobutyryl-CoA hydrolase
chr18_+_7264961 0.46 ENSDART00000188461
CABZ01015105.1

chr23_-_33944597 0.41 ENSDART00000133223
si:dkey-190g6.2
si:dkey-190g6.2
chr22_+_26853254 0.41 ENSDART00000182487
tmem186
transmembrane protein 186
chr19_+_37135700 0.38 ENSDART00000103159
smim12
small integral membrane protein 12
chr18_+_27511976 0.37 ENSDART00000132017
ENSDART00000140781
tp53i11b
tumor protein p53 inducible protein 11b
chr22_+_19366866 0.36 ENSDART00000137301
si:dkey-21e2.12
si:dkey-21e2.12
chr9_+_11034314 0.35 ENSDART00000032695
asic4a
acid-sensing (proton-gated) ion channel family member 4a
chr2_-_11662851 0.25 ENSDART00000145108
zgc:110130
zgc:110130
chr5_+_37837245 0.25 ENSDART00000171617
epd
ependymin
chr18_+_5308392 0.24 ENSDART00000179072
DUT
deoxyuridine triphosphatase
chr3_+_15773991 0.21 ENSDART00000089923
znf652
zinc finger protein 652
chr2_-_20666920 0.19 ENSDART00000143437
ENSDART00000114546
ENSDART00000136113
ENSDART00000179247
dusp12
dual specificity phosphatase 12
chr12_-_3962372 0.18 ENSDART00000016791
eif3c
eukaryotic translation initiation factor 3, subunit C
chr20_+_34717403 0.17 ENSDART00000034252
pnocb
prepronociceptin b
chr12_+_1592146 0.15 ENSDART00000184575
ENSDART00000192902
SLC39A11
solute carrier family 39 member 11
chr11_-_10850936 0.13 ENSDART00000091901
psmd14
proteasome 26S subunit, non-ATPase 14
chr11_+_24851671 0.11 ENSDART00000167659
ipo9
importin 9
chr17_+_2130018 0.07 ENSDART00000193675
ENSDART00000110529
bub1bb
BUB1 mitotic checkpoint serine/threonine kinase Bb
chr1_-_45889820 0.05 ENSDART00000144735
pnpla6
patatin-like phospholipase domain containing 6
chr17_+_7595356 0.04 ENSDART00000130625
si:dkeyp-110a12.4
si:dkeyp-110a12.4
chr2_-_30784198 0.04 ENSDART00000182523
ENSDART00000147355
rgs20
regulator of G protein signaling 20

Network of associatons between targets according to the STRING database.

First level regulatory network of six4a+six4b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 GO:1903373 regulation of endoplasmic reticulum tubular network organization(GO:1903371) positive regulation of endoplasmic reticulum tubular network organization(GO:1903373)
0.8 2.3 GO:0021530 spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.6 2.5 GO:0072149 visceral serous pericardium development(GO:0061032) glomerular visceral epithelial cell fate commitment(GO:0072149) glomerular epithelial cell fate commitment(GO:0072314)
0.5 2.6 GO:0031652 heat generation(GO:0031649) regulation of heat generation(GO:0031650) positive regulation of heat generation(GO:0031652) regulation of phospholipid biosynthetic process(GO:0071071) negative regulation of phospholipid biosynthetic process(GO:0071072)
0.5 2.3 GO:0051659 maintenance of mitochondrion location(GO:0051659)
0.4 2.6 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.4 1.6 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.3 2.3 GO:0050957 equilibrioception(GO:0050957)
0.3 5.1 GO:0014823 response to activity(GO:0014823)
0.2 1.9 GO:0060005 reflex(GO:0060004) vestibular reflex(GO:0060005)
0.2 1.6 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.2 0.9 GO:0060092 regulation of synaptic transmission, glycinergic(GO:0060092)
0.2 2.2 GO:0015813 acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.2 1.8 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.2 0.6 GO:0080120 CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
0.2 1.0 GO:0036371 protein localization to T-tubule(GO:0036371)
0.2 2.0 GO:0098900 regulation of action potential(GO:0098900)
0.2 1.7 GO:0007608 sensory perception of smell(GO:0007608)
0.2 1.4 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.1 2.6 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 0.7 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.1 0.8 GO:0042311 vasodilation(GO:0042311)
0.1 8.6 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.1 1.7 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.1 0.6 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.1 1.6 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.1 0.8 GO:0003428 growth plate cartilage morphogenesis(GO:0003422) chondrocyte intercalation involved in growth plate cartilage morphogenesis(GO:0003428)
0.1 0.5 GO:0007289 spermatid nucleus differentiation(GO:0007289) sperm chromatin condensation(GO:0035092) spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.1 0.5 GO:0006574 valine catabolic process(GO:0006574)
0.1 2.0 GO:0006828 manganese ion transport(GO:0006828)
0.1 0.7 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.6 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 1.1 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 1.7 GO:0042737 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.0 0.5 GO:0048168 regulation of neuronal synaptic plasticity(GO:0048168)
0.0 1.9 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 1.5 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 1.4 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 1.5 GO:0035082 axoneme assembly(GO:0035082)
0.0 1.5 GO:0045214 sarcomere organization(GO:0045214)
0.0 0.4 GO:1901663 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.9 GO:0009266 response to temperature stimulus(GO:0009266)
0.0 1.3 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 2.0 GO:0051260 protein homooligomerization(GO:0051260)
0.0 1.0 GO:0048840 otolith development(GO:0048840)
0.0 0.5 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.0 4.0 GO:0006520 cellular amino acid metabolic process(GO:0006520)
0.0 1.1 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.6 GO:0042255 ribosome assembly(GO:0042255)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 GO:0098826 endoplasmic reticulum tubular network membrane(GO:0098826)
0.2 0.9 GO:1990513 CLOCK-BMAL transcription complex(GO:1990513)
0.2 2.0 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 0.5 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 1.8 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 1.6 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.1 1.4 GO:0071564 npBAF complex(GO:0071564)
0.1 1.0 GO:0030315 T-tubule(GO:0030315)
0.1 3.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 0.8 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 1.7 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 1.5 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 2.1 GO:0015935 small ribosomal subunit(GO:0015935)
0.0 0.7 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 2.2 GO:0000786 nucleosome(GO:0000786)
0.0 0.7 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 2.5 GO:0016607 nuclear speck(GO:0016607)
0.0 2.0 GO:0034703 cation channel complex(GO:0034703)
0.0 6.8 GO:0031012 extracellular matrix(GO:0031012)
0.0 1.5 GO:0005930 axoneme(GO:0005930)
0.0 0.8 GO:0005811 lipid particle(GO:0005811)
0.0 0.6 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 3.4 GO:0005743 mitochondrial inner membrane(GO:0005743)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0072545 tyrosine binding(GO:0072545)
0.4 2.6 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.4 4.0 GO:0004046 aminoacylase activity(GO:0004046)
0.3 1.6 GO:0043295 glutathione binding(GO:0043295)
0.3 0.8 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.2 5.1 GO:0005344 oxygen transporter activity(GO:0005344) oxygen binding(GO:0019825)
0.2 8.6 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.2 2.6 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.2 1.5 GO:0005351 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.2 2.2 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.2 1.0 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.2 1.4 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 2.6 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.1 0.9 GO:0070888 E-box binding(GO:0070888)
0.1 0.9 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 0.7 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.1 2.0 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.1 2.0 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 2.8 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 21.0 GO:0030246 carbohydrate binding(GO:0030246)
0.1 0.9 GO:0005221 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.1 0.9 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 1.6 GO:0016411 acylglycerol O-acyltransferase activity(GO:0016411)
0.1 2.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 1.9 GO:0051020 GTPase binding(GO:0051020)
0.1 0.5 GO:0016504 peptidase activator activity(GO:0016504)
0.1 1.0 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.4 GO:0048039 ubiquinone binding(GO:0048039)
0.0 0.9 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.0 2.1 GO:0019843 rRNA binding(GO:0019843)
0.0 0.8 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 2.7 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 1.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.4 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 1.5 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 1.5 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 0.8 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 1.4 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 2.1 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 0.5 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.7 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 3.8 GO:0042802 identical protein binding(GO:0042802)
0.0 0.5 GO:0016289 CoA hydrolase activity(GO:0016289)
0.0 0.1 GO:0070628 proteasome binding(GO:0070628)
0.0 0.2 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.6 GO:0005347 ATP transmembrane transporter activity(GO:0005347)
0.0 1.1 GO:0051082 unfolded protein binding(GO:0051082)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.0 0.8 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 1.1 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.6 PID SHP2 PATHWAY SHP2 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.1 1.1 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 2.2 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 0.9 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 0.8 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 2.3 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.5 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.6 REACTOME FRS2 MEDIATED CASCADE Genes involved in FRS2-mediated cascade
0.0 0.8 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.5 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.8 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.2 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism