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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for smad2_smad10a+smad4a_smad1

Z-value: 0.97

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Transcription factors associated with smad2_smad10a+smad4a_smad1

Gene Symbol Gene ID Gene Info
ENSDARG00000006389 SMAD family member 2
ENSDARG00000045094 si_dkey-222b8.1
ENSDARG00000070428 si_dkey-222b8.1
ENSDARG00000075226 SMAD family member 4a
ENSDARG00000027199 SMAD family member 1
ENSDARG00000112617 SMAD family member 1
ENSDARG00000115674 SMAD family member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
smad4adr11_v1_chr10_+_575929_5759290.637.7e-12Click!
si:dkey-239n17.4dr11_v1_chr16_-_28876479_288764790.456.0e-06Click!
smad2dr11_v1_chr10_-_14929630_14929679-0.141.8e-01Click!
smad1dr11_v1_chr1_-_35916247_359162470.122.3e-01Click!
si:dkey-222b8.1dr11_v1_chr19_+_23932259_23932259-0.065.7e-01Click!

Activity profile of smad2_smad10a+smad4a_smad1 motif

Sorted Z-values of smad2_smad10a+smad4a_smad1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_3496738 8.30 ENSDART00000186849

chr3_+_26813058 7.58 ENSDART00000055537
suppressor of cytokine signaling 1a
chr9_-_8670158 7.39 ENSDART00000077296
collagen, type IV, alpha 1
chr22_-_557965 6.88 ENSDART00000001201
bystin-like
chr11_+_45255774 6.31 ENSDART00000172838
alveolar soft part sarcoma chromosome region, candidate 1
chr17_+_33433576 5.92 ENSDART00000077581
synaptosomal-associated protein 23.2
chr5_-_3960161 5.71 ENSDART00000111453
myosin XIX
chr4_-_16412084 5.58 ENSDART00000188460
decorin
chr6_-_31827597 5.52 ENSDART00000159400
receptor tyrosine kinase-like orphan receptor 1
chr4_-_21466825 5.42 ENSDART00000066897
PRKC, apoptosis, WT1, regulator
chr13_-_479129 5.36 ENSDART00000159803
ENSDART00000082127
HEAT repeat containing 5B
chr15_+_28303161 5.18 ENSDART00000087926
myosin Ic, paralog b
chr4_-_4932619 5.03 ENSDART00000103293
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
chr5_+_64900223 5.03 ENSDART00000191677
prostaglandin-endoperoxide synthase 1
chr12_+_15165736 4.76 ENSDART00000180398
ADP-ribosylarginine hydrolase
chr20_-_15922986 4.49 ENSDART00000189421
family with sequence similarity 20, member B (H. sapiens)
chr10_+_25272355 4.41 ENSDART00000140186
RAB38b, member of RAS oncogene family
chr19_-_9648542 3.74 ENSDART00000172628
chloride channel, voltage-sensitive 1a
chr25_-_774350 3.57 ENSDART00000166321
ENSDART00000160386
interleukin 1 receptor associated kinase 4
chr18_-_5542351 3.57 ENSDART00000129459
spermatogenesis associated 5-like 1
chr13_-_1130096 3.56 ENSDART00000010261
partner of NOB1 homolog
chr19_-_5380770 3.50 ENSDART00000000221
keratin 91
chr10_-_10018120 3.48 ENSDART00000132375
spermatid perinuclear RNA binding protein
chr4_-_25257451 3.46 ENSDART00000142819
transmembrane protein 110, like
chr20_+_54356540 3.39 ENSDART00000143591
zinc finger protein 410
chr22_-_506522 3.30 ENSDART00000106645
ENSDART00000067637
dual serine/threonine and tyrosine protein kinase
chr22_+_35068046 3.26 ENSDART00000161660
ENSDART00000169573
si:ch73-173h19.3
chr23_-_45405968 3.23 ENSDART00000149462
zgc:101853
chr12_-_4070058 3.23 ENSDART00000042200
aldolase a, fructose-bisphosphate, b
chr11_+_77526 3.17 ENSDART00000193521

chr19_+_19988869 3.17 ENSDART00000151024
oxysterol binding protein-like 3a
chr2_-_42628028 3.14 ENSDART00000179866
myosin X
chr18_-_48755037 3.11 ENSDART00000109673
toll-interleukin 1 receptor (TIR) domain containing adaptor protein
chr19_-_43819582 2.96 ENSDART00000160879
ENSDART00000075902
kelch-like family member 43
chr18_+_5549672 2.95 ENSDART00000184970
nicotinamide nucleotide transhydrogenase 2
chr4_-_797831 2.87 ENSDART00000158970
ENSDART00000170012
microtubule-associated protein, RP/EB family, member 3b
chr7_+_22767678 2.84 ENSDART00000137203
plac8 onzin related protein 6
chr14_-_237130 2.83 ENSDART00000164988
biorientation of chromosomes in cell division 1-like 1
chr2_-_42705284 2.71 ENSDART00000187160
myosin X
chr9_-_180334 2.70 ENSDART00000180339
zgc:158619
chr25_-_31396479 2.69 ENSDART00000156828
proline rich 33
chr12_+_30653047 2.69 ENSDART00000148562
thrombospondin 2b
chr3_+_32526799 2.66 ENSDART00000185755
si:ch73-367p23.2
chr11_+_42585138 2.60 ENSDART00000019008
ankyrin repeat and SOCS box containing 14a
chr20_-_15922210 2.56 ENSDART00000152412
ENSDART00000152354
ENSDART00000152828
ENSDART00000013453
ENSDART00000152357
family with sequence similarity 20, member B (H. sapiens)
chr7_+_56615554 2.54 ENSDART00000098430
dipeptidase 1
chr3_+_32526263 2.41 ENSDART00000150897
si:ch73-367p23.2
chr21_-_45073 2.34 ENSDART00000185997
betaine-homocysteine methyltransferase
chr20_+_23625387 2.30 ENSDART00000147945
ENSDART00000150497
palladin, cytoskeletal associated protein
chr3_+_41714966 2.22 ENSDART00000155440
eukaryotic translation initiation factor 3, subunit Ba
chr14_-_25949951 2.21 ENSDART00000141304
secreted protein, acidic, cysteine-rich (osteonectin)
chr3_-_21242460 2.21 ENSDART00000007293
titin-cap (telethonin)
chr5_-_72125551 2.17 ENSDART00000149412
SET and MYND domain containing 1a
chr22_+_635813 2.17 ENSDART00000179067

chr14_+_51098036 2.16 ENSDART00000184118

chr25_+_32496877 2.15 ENSDART00000132698
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2a
chr24_-_28243186 2.15 ENSDART00000105691
cytochrome c oxidase subunit IV isoform 1, like
chr18_+_50961953 2.13 ENSDART00000158768
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
chr1_+_59073203 2.09 ENSDART00000149937
ENSDART00000162201
si:zfos-2330d3.3
zgc:173915
chr19_+_41551335 2.08 ENSDART00000169193
si:ch211-57n23.4
chr24_+_38306010 2.05 ENSDART00000143184
myosin binding protein C, fast type b
chr16_+_40301056 2.01 ENSDART00000058578
R-spondin 3
chr9_-_35875051 1.96 ENSDART00000013432
DnaJ (Hsp40) homolog, subfamily C, member 28
chr8_+_32719930 1.95 ENSDART00000145362
hemicentin 2
chr4_-_1015896 1.93 ENSDART00000170292
family with sequence similarity 180 member A
chr4_-_17785120 1.90 ENSDART00000024775
myosin binding protein C, slow type
chr4_+_77993103 1.86 ENSDART00000174392
telomeric repeat binding factor a
chr2_-_37098785 1.81 ENSDART00000003670
zgc:101744
chr5_-_34997630 1.77 ENSDART00000170684
basic transcription factor 3
chr13_+_51981764 1.77 ENSDART00000160698
kelch domain containing 3
chr23_-_32156278 1.73 ENSDART00000157479
nuclear receptor subfamily 4, group A, member 1
chr5_+_27898226 1.69 ENSDART00000098604
ENSDART00000180251
ADAM metallopeptidase domain 28
chr3_+_30257582 1.68 ENSDART00000159497
ENSDART00000103457
ENSDART00000121883
myosin binding protein C, fast type a
chr23_+_36460239 1.68 ENSDART00000172441
LIM domain and actin binding 1a
chr17_-_122680 1.65 ENSDART00000066430
actin, alpha, cardiac muscle 1b
chr14_-_6987649 1.64 ENSDART00000060990
eukaryotic translation initiation factor 4E binding protein 3, like
chr19_+_48111285 1.63 ENSDART00000169420
NME/NM23 nucleoside diphosphate kinase 2b, tandem duplicate 2
chr20_+_18163355 1.62 ENSDART00000011287
aquaporin 4
chr8_-_14126646 1.62 ENSDART00000027225
biglycan a
chr6_-_15653494 1.60 ENSDART00000038133
tripartite motif containing 63a
chr10_+_35526528 1.58 ENSDART00000184110
pleckstrin homology-like domain, family B, member 2a
chr19_+_4061699 1.56 ENSDART00000158309
ENSDART00000166512
bloodthirsty-related gene family, member 25
bloodthirsty-related gene family, member 26
chr2_+_58739111 1.56 ENSDART00000097690

chr9_+_23900703 1.55 ENSDART00000127859
tripartite motif containing 63b
chr23_+_25995727 1.54 ENSDART00000137123
WNT1 inducible signaling pathway protein 2
chr16_-_11961325 1.52 ENSDART00000143845
si:ch73-296e2.3
chr24_-_24281792 1.51 ENSDART00000146482
ENSDART00000018420
pyruvate dehydrogenase E1 alpha 1 subunit b
chr7_-_18508815 1.49 ENSDART00000173539
regulator of G protein signaling 12a
chr3_-_31019715 1.46 ENSDART00000156687
ENSDART00000156127
ENSDART00000153945
si:dkeyp-71f10.5
chr6_-_49526510 1.45 ENSDART00000128025
ribosomal protein S26, like
chr18_-_44908479 1.44 ENSDART00000169636
si:ch211-71n6.4
chr9_-_34191627 1.44 ENSDART00000142664
ddb1 and cul4 associated factor 6
chr20_+_7084154 1.40 ENSDART00000136448
finTRIM family, member 85
chr14_-_736575 1.39 ENSDART00000168611
toll-like receptor 1
chr8_-_40070114 1.39 ENSDART00000036280
gamma-glutamyltransferase 1a
chr1_+_1805294 1.38 ENSDART00000103850
ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 3
chr17_-_15546862 1.38 ENSDART00000091021
collagen, type X, alpha 1a
chr4_+_55758103 1.37 ENSDART00000185964

chr19_+_43119698 1.37 ENSDART00000167847
ENSDART00000186962
ENSDART00000187305
eukaryotic translation elongation factor 1 alpha 1, like 1
chr19_-_81851 1.37 ENSDART00000172319
heterogeneous nuclear ribonucleoprotein R
chr2_-_2642476 1.35 ENSDART00000124032
SERPINE1 mRNA binding protein 1b
chr20_-_2355357 1.32 ENSDART00000085281
si:ch73-18b11.1
chr12_-_17712393 1.32 ENSDART00000143534
ENSDART00000010144
parvalbumin 2
chr7_-_69857692 1.32 ENSDART00000124764
myozenin 2a
chr9_+_310331 1.30 ENSDART00000172446
ENSDART00000187731
ENSDART00000193970
SH3 and cysteine rich domain 3
chr21_+_5993188 1.29 ENSDART00000048399
solute carrier family 4 (sodium bicarbonate cotransporter), member 4b
chr13_+_22480496 1.27 ENSDART00000136863
ENSDART00000131870
ENSDART00000078720
ENSDART00000078740
ENSDART00000139218
LIM domain binding 3a
chr11_-_13152524 1.27 ENSDART00000181440
ENSDART00000191997
ELOVL fatty acid elongase 1b
chr21_+_30351256 1.25 ENSDART00000078341
forkhead box I3a
chr23_+_19790962 1.25 ENSDART00000142228
filamin A, alpha (actin binding protein 280)
chr6_-_29195642 1.24 ENSDART00000078625
dermatopontin
chr23_-_46040618 1.24 ENSDART00000161415

chr1_-_681116 1.23 ENSDART00000165894
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr3_-_29928695 1.23 ENSDART00000151275
ENSDART00000151083
granulin a
chr22_+_3303671 1.23 ENSDART00000075049
GIPC PDZ domain containing family, member 3
chr10_-_35149513 1.21 ENSDART00000063434
ENSDART00000131291
receptor-interacting serine-threonine kinase 4
chr9_+_44304980 1.21 ENSDART00000147990
sperm specific antigen 2
chr17_+_24843401 1.20 ENSDART00000110179
connexin 34.4
chr21_+_33454147 1.20 ENSDART00000053208
ribosomal protein S14
chr20_+_50061890 1.20 ENSDART00000137725
cleavage and polyadenylation specific factor 2
chr24_-_4768955 1.19 ENSDART00000066834
angiotensin II receptor, type 1b
chr3_+_13879446 1.19 ENSDART00000164767
phenylalanyl-tRNA synthetase, alpha subunit
chr16_-_26132122 1.16 ENSDART00000157787
lipase, hormone-sensitive b
chr15_-_28082310 1.16 ENSDART00000152620
dehydrogenase/reductase (SDR family) member 13a, duplicate 3
chr21_+_10866421 1.15 ENSDART00000137858
alpha-kinase 2
chr5_+_34997763 1.15 ENSDART00000043341
forkhead box D1
chr19_-_82504 1.15 ENSDART00000027864
ENSDART00000160560
heterogeneous nuclear ribonucleoprotein R
chr20_+_54356272 1.15 ENSDART00000145735
zinc finger protein 410
chr25_-_6261693 1.14 ENSDART00000135808
iron-responsive element binding protein 2
chr19_-_38611814 1.12 ENSDART00000151958
collagen, type XVI, alpha 1
chr22_+_18886209 1.11 ENSDART00000144402
follistatin-like 3 (secreted glycoprotein)
chr1_+_36552 1.10 ENSDART00000169685
Hikeshi, heat shock protein nuclear import factor
chr9_-_23922011 1.10 ENSDART00000145734
collagen, type VI, alpha 3
chr3_-_48980319 1.08 ENSDART00000165319
finTRIM family, member 42
chr25_+_245018 1.08 ENSDART00000155344
zgc:92481
chr3_+_5331428 1.08 ENSDART00000156561
si:ch73-106l15.4
chr5_+_8964926 1.07 ENSDART00000091397
ENSDART00000164535
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase b
chr14_-_12307522 1.06 ENSDART00000163900
myotilin
chr21_-_11632403 1.06 ENSDART00000171708
ENSDART00000138619
ENSDART00000136308
ENSDART00000144770
calpastatin
chr24_+_6353394 1.05 ENSDART00000165118

chr23_-_17470146 1.04 ENSDART00000002398
tripartite motif containing 101
chr5_-_1962500 1.04 ENSDART00000150163
ribosomal protein, large, P0
chr7_+_9290929 1.04 ENSDART00000128530
small nuclear ribonucleoprotein polypeptide A'
chr4_+_41602 1.03 ENSDART00000159640
putative homeodomain transcription factor 2
chr19_-_3574060 1.03 ENSDART00000105120
transmembrane protein 170B
chr13_-_36418921 1.02 ENSDART00000135804
ddb1 and cul4 associated factor 5
chr19_+_4062101 1.01 ENSDART00000166773
bloodthirsty-related gene family, member 25
chr18_+_30847237 1.01 ENSDART00000012374
forkhead box F1
chr15_-_47468085 1.01 ENSDART00000164438
inositol polyphosphate phosphatase-like 1a
chr12_+_33894396 1.00 ENSDART00000130853
ENSDART00000152988
major facilitator superfamily domain containing 13A
chr20_+_46544052 0.99 ENSDART00000098968
si:ch211-153j24.3
chr20_-_31427390 0.99 ENSDART00000007735
uronyl-2-sulfotransferase
chr6_-_60104628 0.99 ENSDART00000057463
ENSDART00000169188
prostate transmembrane protein, androgen induced 1
chr11_-_141592 0.99 ENSDART00000092787
cyclin-dependent kinase 4
chr11_+_141504 0.99 ENSDART00000086166
zgc:172352
chr25_+_37340722 0.98 ENSDART00000137025
peptidase domain containing associated with muscle regeneration 1
chr16_+_54588930 0.98 ENSDART00000159174
DENN/MADD domain containing 4B
chr25_-_3892686 0.98 ENSDART00000043172
transmembrane protein 258
chr5_-_33286820 0.98 ENSDART00000184426
ribosomal protein L7a
chr20_+_34400715 0.97 ENSDART00000061632
family with sequence similarity 129, member Aa
chr2_+_13069168 0.97 ENSDART00000192832
protein kinase, AMP-activated, gamma 2 non-catalytic subunit b
chr22_+_661505 0.95 ENSDART00000149460
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr6_-_24103666 0.95 ENSDART00000164915
scinderin like a
chr12_-_49165751 0.95 ENSDART00000148491
ENSDART00000112479
acyl-CoA dehydrogenase short/branched chain
chr22_-_18779232 0.95 ENSDART00000186726
ATP synthase F1 subunit delta
chr24_+_39990695 0.93 ENSDART00000040281

chr5_+_483965 0.93 ENSDART00000150007
TEK tyrosine kinase, endothelial
chr14_+_11458044 0.93 ENSDART00000186425
si:ch211-153b23.5
chr12_-_5505205 0.93 ENSDART00000092319
ABI family, member 3b
chr3_-_1388936 0.93 ENSDART00000171278
DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
chr22_+_26400519 0.92 ENSDART00000159839
ENSDART00000144585
calpain 8
chr10_+_29259882 0.92 ENSDART00000180606
synaptotagmin-like 2a
chr13_+_22480857 0.91 ENSDART00000078721
ENSDART00000044719
ENSDART00000130957
ENSDART00000078757
ENSDART00000130424
ENSDART00000078747
LIM domain binding 3a
chr4_+_77933084 0.91 ENSDART00000148728
protein kinase C and casein kinase substrate in neurons 2
chr23_-_24263474 0.91 ENSDART00000160312
heat shock protein family, member 7 (cardiovascular)
chr19_-_5369486 0.90 ENSDART00000105004
keratin 17
chr5_-_58780160 0.90 ENSDART00000166955
Rho guanine nucleotide exchange factor (GEF) 12b
chr23_+_43200911 0.90 ENSDART00000164262
si:dkey-65j6.2
chr17_-_52091999 0.89 ENSDART00000019766
transforming growth factor, beta 3
chr6_+_103361 0.89 ENSDART00000151899
low density lipoprotein receptor b
chr13_-_280652 0.88 ENSDART00000193627
solute carrier family 30 (zinc transporter), member 6
chr8_-_28304534 0.88 ENSDART00000078545
leiomodin 1a (smooth muscle)
chr9_+_307863 0.87 ENSDART00000163474
SH3 and cysteine rich domain 3
chr3_-_1434135 0.87 ENSDART00000149622
matrix Gla protein
chr11_+_42556395 0.87 ENSDART00000039206
ribosomal protein S23
chr14_+_2243 0.87 ENSDART00000191193
cytokine like 1
chr7_-_51433903 0.87 ENSDART00000083189
Rho GTPase activating protein 36
chr12_-_628024 0.87 ENSDART00000158563
ENSDART00000152612
wu:fj29h11
si:ch73-301j1.1
chr19_+_47394270 0.86 ENSDART00000171281
proteasome subunit beta 2
chr22_+_38824012 0.85 ENSDART00000144318
ENSDART00000003736
anosmin 1b
chr11_-_44999858 0.85 ENSDART00000167759
ENSDART00000126845
LIM-domain binding 1b
chr2_-_59265521 0.85 ENSDART00000146341
ENSDART00000097799
finTRIM family, member 33
chr11_-_44647286 0.84 ENSDART00000169329
ENSDART00000158939
translocase of outer mitochondrial membrane 20b
chr22_+_661711 0.84 ENSDART00000113795
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr11_+_40032790 0.84 ENSDART00000158809
si:dkey-264d12.1
chr14_-_52583021 0.84 ENSDART00000166924

chr5_+_18047111 0.84 ENSDART00000132164
histone cell cycle regulator a
chr23_+_43201142 0.84 ENSDART00000158832
ENSDART00000190315
si:dkey-65j6.2
chr8_+_554531 0.84 ENSDART00000193623

chr1_-_633356 0.84 ENSDART00000171019
amyloid beta (A4) precursor protein a

Network of associatons between targets according to the STRING database.

First level regulatory network of smad2_smad10a+smad4a_smad1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.8 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
1.3 7.6 GO:0060330 regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
1.3 5.0 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.7 2.9 GO:0006740 NADPH regeneration(GO:0006740)
0.6 2.2 GO:0035994 response to muscle stretch(GO:0035994)
0.5 2.0 GO:0060829 negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
0.5 1.9 GO:0032207 regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208)
0.4 2.2 GO:1901387 positive regulation of voltage-gated calcium channel activity(GO:1901387)
0.4 1.6 GO:0014743 regulation of muscle hypertrophy(GO:0014743)
0.4 1.2 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.4 1.2 GO:0071831 chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830) intermediate-density lipoprotein particle clearance(GO:0071831)
0.4 3.3 GO:0060036 notochord cell vacuolation(GO:0060036)
0.4 2.8 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.3 6.2 GO:0043114 regulation of vascular permeability(GO:0043114)
0.3 2.9 GO:0035372 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.3 1.3 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.3 16.7 GO:0099515 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.3 1.3 GO:0009957 epidermal cell fate specification(GO:0009957)
0.3 2.0 GO:0090497 mesenchymal cell migration(GO:0090497)
0.3 1.1 GO:1904355 positive regulation of telomere maintenance(GO:0032206) regulation of telomere capping(GO:1904353) positive regulation of telomere capping(GO:1904355)
0.3 0.8 GO:0090069 regulation of ribosome biogenesis(GO:0090069)
0.3 6.9 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068)
0.3 0.3 GO:0010155 regulation of proton transport(GO:0010155)
0.2 2.2 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
0.2 0.7 GO:0065001 specification of axis polarity(GO:0065001)
0.2 0.7 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.2 0.7 GO:0070314 G1 to G0 transition(GO:0070314)
0.2 1.6 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.2 1.3 GO:0035989 tendon development(GO:0035989)
0.2 0.6 GO:0060631 regulation of meiosis I(GO:0060631)
0.2 1.7 GO:0031179 peptide modification(GO:0031179)
0.2 6.3 GO:0016082 synaptic vesicle priming(GO:0016082)
0.2 5.6 GO:0010508 positive regulation of autophagy(GO:0010508)
0.2 0.8 GO:0010755 regulation of plasminogen activation(GO:0010755)
0.2 3.1 GO:0003313 heart rudiment development(GO:0003313)
0.2 2.5 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.2 3.9 GO:0032438 melanosome organization(GO:0032438)
0.2 1.7 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.2 1.0 GO:0060836 lymphatic endothelial cell differentiation(GO:0060836)
0.2 1.3 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.2 0.7 GO:0046168 NADH oxidation(GO:0006116) glycerol-3-phosphate catabolic process(GO:0046168)
0.2 0.7 GO:0014045 establishment of endothelial blood-brain barrier(GO:0014045)
0.2 1.6 GO:0006833 water transport(GO:0006833)
0.2 1.2 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.2 0.5 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
0.2 0.8 GO:0051031 tRNA transport(GO:0051031)
0.2 1.2 GO:0002689 negative regulation of leukocyte chemotaxis(GO:0002689) negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024) negative regulation of neutrophil migration(GO:1902623)
0.2 1.1 GO:0051705 multi-organism behavior(GO:0051705)
0.2 0.5 GO:1902893 pri-miRNA transcription from RNA polymerase II promoter(GO:0061614) regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902893) positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895)
0.2 2.3 GO:0009086 methionine biosynthetic process(GO:0009086)
0.2 0.5 GO:0009912 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.2 0.8 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.2 0.5 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.2 1.2 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.2 0.6 GO:0015840 urea transport(GO:0015840)
0.2 0.5 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.2 1.1 GO:0097340 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
0.1 0.9 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.1 2.1 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.1 0.1 GO:0014066 regulation of phosphatidylinositol 3-kinase signaling(GO:0014066)
0.1 1.0 GO:0060017 parathyroid gland development(GO:0060017)
0.1 0.4 GO:0006480 N-terminal protein amino acid methylation(GO:0006480)
0.1 1.4 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.1 2.1 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 0.6 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.1 1.0 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 0.5 GO:0072512 ferric iron transport(GO:0015682) transferrin transport(GO:0033572) trivalent inorganic cation transport(GO:0072512)
0.1 0.7 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.1 1.1 GO:0034605 cellular response to heat(GO:0034605)
0.1 0.8 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 0.6 GO:0002159 desmosome assembly(GO:0002159)
0.1 0.3 GO:0044205 'de novo' UMP biosynthetic process(GO:0044205)
0.1 0.9 GO:0001765 membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.1 2.0 GO:0036376 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.1 1.1 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.1 0.7 GO:0097350 neutrophil apoptotic process(GO:0001781) regulation of T-helper 1 type immune response(GO:0002825) positive regulation of T-helper 1 type immune response(GO:0002827) negative regulation of type 2 immune response(GO:0002829) inflammatory cell apoptotic process(GO:0006925) regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of phospholipase A2 activity(GO:0032429) interleukin-2 production(GO:0032623) regulation of interleukin-2 production(GO:0032663) positive regulation of interleukin-2 production(GO:0032743) myeloid cell apoptotic process(GO:0033028) regulation of neutrophil apoptotic process(GO:0033029) positive regulation of neutrophil apoptotic process(GO:0033031) regulation of myeloid cell apoptotic process(GO:0033032) positive regulation of myeloid cell apoptotic process(GO:0033034) T-helper 1 type immune response(GO:0042088) positive regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043372) T-helper 1 cell differentiation(GO:0045063) positive regulation of T-helper cell differentiation(GO:0045624) regulation of T-helper 1 cell differentiation(GO:0045625) positive regulation of T-helper 1 cell differentiation(GO:0045627) regulation of T-helper 2 cell differentiation(GO:0045628) negative regulation of T-helper 2 cell differentiation(GO:0045629) positive regulation of fatty acid biosynthetic process(GO:0045723) positive regulation of alpha-beta T cell differentiation(GO:0046638) neutrophil clearance(GO:0097350) negative regulation of phospholipase A2 activity(GO:1900138) positive regulation of CD4-positive, alpha-beta T cell activation(GO:2000516) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.1 2.6 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 0.7 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.1 1.6 GO:0046051 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.1 0.4 GO:0061033 lung growth(GO:0060437) secretion by lung epithelial cell involved in lung growth(GO:0061033)
0.1 2.4 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.1 0.5 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.1 6.2 GO:0030166 proteoglycan biosynthetic process(GO:0030166)
0.1 0.4 GO:0033153 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.1 0.1 GO:0048338 axial mesoderm structural organization(GO:0048331) mesoderm structural organization(GO:0048338)
0.1 0.4 GO:0015865 intracellular nucleoside transport(GO:0015859) purine nucleoside transmembrane transport(GO:0015860) purine nucleotide transport(GO:0015865) ATP transport(GO:0015867) purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503) mitochondrial ATP transmembrane transport(GO:1990544)
0.1 0.3 GO:0010658 negative regulation of muscle cell apoptotic process(GO:0010656) muscle cell apoptotic process(GO:0010657) striated muscle cell apoptotic process(GO:0010658) regulation of muscle cell apoptotic process(GO:0010660) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664)
0.1 0.5 GO:0035776 pronephric proximal tubule development(GO:0035776)
0.1 0.4 GO:0014909 smooth muscle cell migration(GO:0014909)
0.1 5.4 GO:0022904 respiratory electron transport chain(GO:0022904)
0.1 0.3 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.1 0.2 GO:0045064 T-helper 2 cell differentiation(GO:0045064)
0.1 0.7 GO:0042554 superoxide anion generation(GO:0042554)
0.1 1.3 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 5.4 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.1 0.3 GO:0007509 mesoderm migration involved in gastrulation(GO:0007509)
0.1 0.6 GO:0034650 cortisol metabolic process(GO:0034650)
0.1 0.2 GO:0071314 response to cocaine(GO:0042220) cellular response to alkaloid(GO:0071312) cellular response to cocaine(GO:0071314)
0.1 0.5 GO:0045337 farnesyl diphosphate biosynthetic process(GO:0045337)
0.1 1.5 GO:0042574 retinal metabolic process(GO:0042574)
0.1 1.9 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 0.8 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.1 0.6 GO:0008298 intracellular mRNA localization(GO:0008298)
0.1 1.5 GO:0070672 interleukin-15-mediated signaling pathway(GO:0035723) response to interleukin-15(GO:0070672) cellular response to interleukin-15(GO:0071350)
0.1 0.6 GO:0050779 RNA destabilization(GO:0050779) mRNA destabilization(GO:0061157)
0.1 0.7 GO:2000377 regulation of reactive oxygen species metabolic process(GO:2000377)
0.1 0.4 GO:0048194 Golgi vesicle budding(GO:0048194)
0.1 0.2 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.1 0.8 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.1 0.2 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.1 0.8 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.1 0.3 GO:0036306 embryonic heart tube elongation(GO:0036306)
0.1 0.3 GO:0061011 hepatic duct development(GO:0061011)
0.1 0.8 GO:0032925 regulation of activin receptor signaling pathway(GO:0032925) regulation of nodal signaling pathway(GO:1900107)
0.1 1.2 GO:0019433 triglyceride catabolic process(GO:0019433)
0.1 0.6 GO:0010888 negative regulation of cholesterol storage(GO:0010887) negative regulation of lipid storage(GO:0010888)
0.1 0.8 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.1 0.3 GO:0098535 de novo centriole assembly(GO:0098535)
0.1 0.4 GO:0033986 response to methanol(GO:0033986) cellular response to methanol(GO:0071405)
0.1 0.2 GO:0033632 cell-cell adhesion mediated by integrin(GO:0033631) regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.1 2.9 GO:0009395 phospholipid catabolic process(GO:0009395)
0.1 0.5 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.1 2.0 GO:0051014 actin filament severing(GO:0051014)
0.1 0.2 GO:0010456 cell proliferation in dorsal spinal cord(GO:0010456)
0.1 0.2 GO:0009162 deoxyribonucleoside monophosphate metabolic process(GO:0009162)
0.1 0.6 GO:0086002 cardiac muscle cell action potential involved in contraction(GO:0086002)
0.1 0.7 GO:1990118 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 0.4 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.1 0.2 GO:0045687 positive regulation of glial cell differentiation(GO:0045687) positive regulation of oligodendrocyte differentiation(GO:0048714)
0.1 2.1 GO:0061035 regulation of cartilage development(GO:0061035)
0.1 0.4 GO:0061056 sclerotome development(GO:0061056)
0.1 0.6 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.1 0.2 GO:0032060 bleb assembly(GO:0032060) slow muscle cell migration(GO:1904969)
0.1 0.3 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 1.1 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.1 0.2 GO:0016446 somatic diversification of immune receptors via somatic mutation(GO:0002566) pyrimidine dimer repair(GO:0006290) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.1 2.8 GO:0007173 epidermal growth factor receptor signaling pathway(GO:0007173)
0.1 0.8 GO:0070654 sensory epithelium regeneration(GO:0070654) epithelium regeneration(GO:1990399)
0.1 0.5 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.1 0.2 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 2.1 GO:0030199 collagen fibril organization(GO:0030199)
0.1 0.3 GO:0039689 viral genome replication(GO:0019079) negative stranded viral RNA replication(GO:0039689) viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) multi-organism biosynthetic process(GO:0044034)
0.1 0.7 GO:0060021 palate development(GO:0060021)
0.1 0.5 GO:1901998 toxin transport(GO:1901998)
0.1 0.6 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.1 0.2 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371) positive regulation of endoplasmic reticulum tubular network organization(GO:1903373)
0.1 1.2 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 0.2 GO:0070084 protein initiator methionine removal(GO:0070084)
0.0 0.2 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0 0.7 GO:0042509 tyrosine phosphorylation of STAT protein(GO:0007260) regulation of tyrosine phosphorylation of STAT protein(GO:0042509)
0.0 0.2 GO:0018377 N-terminal protein myristoylation(GO:0006499) N-terminal peptidyl-glycine N-myristoylation(GO:0018008) protein myristoylation(GO:0018377)
0.0 0.3 GO:0097010 eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.0 0.7 GO:0032264 IMP salvage(GO:0032264)
0.0 1.5 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 1.5 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.7 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.0 0.4 GO:0033273 response to vitamin(GO:0033273)
0.0 0.1 GO:0044241 intestinal cholesterol absorption(GO:0030299) lipid digestion(GO:0044241)
0.0 0.3 GO:0048662 regulation of smooth muscle cell proliferation(GO:0048660) negative regulation of smooth muscle cell proliferation(GO:0048662)
0.0 2.2 GO:0055013 cardiac muscle cell development(GO:0055013)
0.0 5.9 GO:0006364 rRNA processing(GO:0006364)
0.0 0.3 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.0 0.3 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.1 GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis.(GO:0002926)
0.0 0.3 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.2 GO:0090133 mesendoderm migration(GO:0090133) cell migration involved in mesendoderm migration(GO:0090134)
0.0 0.9 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 1.2 GO:0019229 regulation of vasoconstriction(GO:0019229)
0.0 0.2 GO:0031087 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.3 GO:0016137 glycoside metabolic process(GO:0016137) glycoside catabolic process(GO:0016139)
0.0 0.4 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.0 0.2 GO:1902093 positive regulation of sperm motility(GO:1902093)
0.0 0.5 GO:2000142 regulation of transcription initiation from RNA polymerase II promoter(GO:0060260) regulation of DNA-templated transcription, initiation(GO:2000142)
0.0 0.9 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 1.1 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.5 GO:0031641 regulation of myelination(GO:0031641)
0.0 0.2 GO:0006083 acetate metabolic process(GO:0006083) acetyl-CoA biosynthetic process from acetate(GO:0019427)
0.0 0.3 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 1.0 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.0 0.7 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.6 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 0.2 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 5.8 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.0 0.2 GO:1901073 chitin biosynthetic process(GO:0006031) glucosamine-containing compound biosynthetic process(GO:1901073)
0.0 0.4 GO:0043536 positive regulation of blood vessel endothelial cell migration(GO:0043536) positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.7 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.1 GO:0032957 inositol trisphosphate metabolic process(GO:0032957)
0.0 0.4 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.0 2.4 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 0.8 GO:0043491 protein kinase B signaling(GO:0043491)
0.0 0.6 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 0.5 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.0 0.3 GO:1901099 histone dephosphorylation(GO:0016576) negative regulation of signal transduction in absence of ligand(GO:1901099) regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001239) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.0 0.2 GO:0030908 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.0 0.3 GO:0046620 regulation of organ growth(GO:0046620)
0.0 0.2 GO:0016127 steroid catabolic process(GO:0006706) cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 0.2 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.2 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 0.4 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.3 GO:0097531 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 0.1 GO:0043504 mitochondrial DNA repair(GO:0043504)
0.0 0.1 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.0 2.9 GO:0007283 spermatogenesis(GO:0007283)
0.0 0.8 GO:0045104 intermediate filament-based process(GO:0045103) intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.2 GO:0061511 centriole elongation(GO:0061511)
0.0 0.7 GO:0007631 feeding behavior(GO:0007631)
0.0 0.1 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.2 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.0 0.2 GO:0039023 pronephric duct morphogenesis(GO:0039023)
0.0 2.3 GO:0031101 fin regeneration(GO:0031101)
0.0 0.4 GO:0098754 detoxification(GO:0098754)
0.0 0.0 GO:0090022 regulation of neutrophil chemotaxis(GO:0090022)
0.0 1.5 GO:0006414 translational elongation(GO:0006414)
0.0 0.1 GO:0018197 peptidyl-aspartic acid modification(GO:0018197) peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.3 GO:0055078 sodium ion homeostasis(GO:0055078)
0.0 0.2 GO:0018120 peptidyl-arginine ADP-ribosylation(GO:0018120)
0.0 0.4 GO:0030048 actin filament-based movement(GO:0030048)
0.0 0.7 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 1.2 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 0.7 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.3 GO:0009409 response to cold(GO:0009409)
0.0 1.4 GO:0051017 actin filament bundle assembly(GO:0051017)
0.0 0.1 GO:0060323 head morphogenesis(GO:0060323) face morphogenesis(GO:0060325)
0.0 1.4 GO:0060537 muscle tissue development(GO:0060537)
0.0 1.0 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 0.7 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.0 0.3 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 0.5 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.1 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.0 0.6 GO:0019882 antigen processing and presentation(GO:0019882)
0.0 0.5 GO:0060972 left/right pattern formation(GO:0060972)
0.0 0.2 GO:0048922 posterior lateral line neuromast deposition(GO:0048922)
0.0 0.1 GO:0008344 adult locomotory behavior(GO:0008344)
0.0 0.1 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 0.1 GO:0006662 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.0 0.3 GO:0010962 regulation of glycogen biosynthetic process(GO:0005979) regulation of glucan biosynthetic process(GO:0010962)
0.0 0.9 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 1.3 GO:0001666 response to hypoxia(GO:0001666)
0.0 0.5 GO:0048332 mesoderm morphogenesis(GO:0048332)
0.0 0.2 GO:0022011 Schwann cell differentiation(GO:0014037) Schwann cell development(GO:0014044) myelination in peripheral nervous system(GO:0022011)
0.0 0.4 GO:0045214 sarcomere organization(GO:0045214)
0.0 1.6 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 0.2 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.1 GO:0006478 protein sulfation(GO:0006477) peptidyl-tyrosine sulfation(GO:0006478)
0.0 0.2 GO:0071910 determination of liver left/right asymmetry(GO:0071910)
0.0 0.1 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.1 GO:0042403 thyroid hormone metabolic process(GO:0042403)
0.0 0.6 GO:0001570 vasculogenesis(GO:0001570)
0.0 0.1 GO:0051013 microtubule severing(GO:0051013)
0.0 0.2 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.0 0.2 GO:0061386 closure of optic fissure(GO:0061386)
0.0 0.4 GO:0019835 cytolysis(GO:0019835)
0.0 0.4 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.3 GO:0048546 digestive tract morphogenesis(GO:0048546)
0.0 0.6 GO:0006405 RNA export from nucleus(GO:0006405)
0.0 0.3 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.3 GO:0030500 regulation of bone mineralization(GO:0030500) regulation of biomineral tissue development(GO:0070167)
0.0 0.6 GO:0070830 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.0 0.3 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.0 0.0 GO:0046379 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.0 0.5 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.2 GO:0007035 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.0 0.2 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 1.1 GO:0002757 immune response-activating signal transduction(GO:0002757)
0.0 0.6 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 0.8 GO:0031047 gene silencing by RNA(GO:0031047)
0.0 0.2 GO:0035675 neuromast hair cell development(GO:0035675)
0.0 0.1 GO:0060538 skeletal muscle organ development(GO:0060538)
0.0 0.2 GO:0007004 RNA-dependent DNA biosynthetic process(GO:0006278) telomere maintenance via telomerase(GO:0007004)
0.0 0.2 GO:0036065 fucosylation(GO:0036065)
0.0 0.3 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.0 0.1 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.0 GO:0016038 absorption of visible light(GO:0016038)
0.0 0.2 GO:0031936 negative regulation of chromatin silencing(GO:0031936) negative regulation of gene silencing(GO:0060969)
0.0 1.7 GO:0006954 inflammatory response(GO:0006954)
0.0 0.8 GO:0001503 ossification(GO:0001503)
0.0 0.2 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0 0.8 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 0.7 GO:0070121 Kupffer's vesicle development(GO:0070121)
0.0 0.1 GO:0000710 meiotic mismatch repair(GO:0000710)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 6.9 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.3 1.8 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.3 1.2 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.2 0.7 GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
0.2 0.9 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.2 0.7 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.2 2.5 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.2 0.5 GO:0043218 compact myelin(GO:0043218) Schmidt-Lanterman incisure(GO:0043220)
0.2 2.2 GO:0017119 Golgi transport complex(GO:0017119)
0.2 2.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.2 2.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 0.9 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1 2.2 GO:0030315 T-tubule(GO:0030315)
0.1 0.4 GO:0042709 succinate-CoA ligase complex(GO:0042709)
0.1 16.7 GO:0016459 myosin complex(GO:0016459)
0.1 5.4 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 1.9 GO:0070187 telosome(GO:0070187)
0.1 0.7 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 7.0 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 2.9 GO:0035371 microtubule plus-end(GO:0035371)
0.1 10.0 GO:0005581 collagen trimer(GO:0005581)
0.1 4.2 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 1.7 GO:0005869 dynactin complex(GO:0005869)
0.1 2.2 GO:0031430 M band(GO:0031430)
0.1 0.8 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 2.2 GO:0016282 eukaryotic 43S preinitiation complex(GO:0016282)
0.1 0.6 GO:1902636 kinociliary basal body(GO:1902636)
0.1 4.2 GO:0031941 filamentous actin(GO:0031941)
0.1 0.7 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 2.1 GO:0045180 basal cortex(GO:0045180)
0.1 0.8 GO:0071797 LUBAC complex(GO:0071797)
0.1 0.4 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.1 2.5 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 0.6 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 0.8 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 0.6 GO:0031672 A band(GO:0031672)
0.1 0.6 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 1.2 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1 0.4 GO:0005784 Sec61 translocon complex(GO:0005784)
0.1 0.4 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 3.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 6.4 GO:0031201 SNARE complex(GO:0031201)
0.1 1.0 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 5.4 GO:0030139 endocytic vesicle(GO:0030139)
0.1 0.7 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 0.8 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 0.3 GO:0032807 DNA ligase IV complex(GO:0032807)
0.1 0.2 GO:0032301 MutSalpha complex(GO:0032301)
0.1 4.6 GO:0030018 Z disc(GO:0030018)
0.1 6.0 GO:0005882 intermediate filament(GO:0005882)
0.1 3.0 GO:0031901 early endosome membrane(GO:0031901)
0.1 3.5 GO:0022626 cytosolic large ribosomal subunit(GO:0022625) cytosolic ribosome(GO:0022626)
0.1 1.5 GO:0005839 proteasome core complex(GO:0005839)
0.1 0.2 GO:0098826 endoplasmic reticulum tubular network membrane(GO:0098826)
0.1 0.4 GO:0097225 sperm midpiece(GO:0097225)
0.0 2.1 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 5.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.3 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.6 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.2 GO:0005913 cell-cell adherens junction(GO:0005913) zonula adherens(GO:0005915)
0.0 0.3 GO:0030914 STAGA complex(GO:0030914)
0.0 0.2 GO:0070209 ASTRA complex(GO:0070209)
0.0 0.5 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.1 GO:0098536 deuterosome(GO:0098536)
0.0 0.1 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.8 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.1 GO:0008352 katanin complex(GO:0008352)
0.0 3.1 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.5 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.6 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.6 GO:0030057 desmosome(GO:0030057)
0.0 0.2 GO:0032783 ELL-EAF complex(GO:0032783)
0.0 0.7 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.2 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.1 GO:1990513 CLOCK-BMAL transcription complex(GO:1990513)
0.0 0.1 GO:0005775 vacuolar lumen(GO:0005775) lysosomal lumen(GO:0043202)
0.0 0.2 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 1.4 GO:0016592 mediator complex(GO:0016592)
0.0 1.2 GO:0005643 nuclear pore(GO:0005643)
0.0 0.4 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.2 GO:0030428 cell septum(GO:0030428)
0.0 0.1 GO:0031310 integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
0.0 1.2 GO:0048786 presynaptic active zone(GO:0048786)
0.0 2.3 GO:0016607 nuclear speck(GO:0016607)
0.0 0.9 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 1.0 GO:0005865 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.0 1.3 GO:0005884 actin filament(GO:0005884)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.2 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 4.7 GO:0009986 cell surface(GO:0009986)
0.0 0.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.2 GO:0000124 SAGA complex(GO:0000124)
0.0 0.2 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 2.4 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.3 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.1 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.0 0.0 GO:1902560 GMP reductase complex(GO:1902560)
0.0 0.4 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 1.0 GO:0030055 cell-substrate junction(GO:0030055)
0.0 0.3 GO:0008305 integrin complex(GO:0008305)
0.0 0.2 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 3.5 GO:0000785 chromatin(GO:0000785)
0.0 13.7 GO:0005615 extracellular space(GO:0005615)
0.0 0.2 GO:1990907 beta-catenin-TCF complex(GO:1990907)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.8 GO:0003875 ADP-ribosylarginine hydrolase activity(GO:0003875)
1.3 5.0 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
1.1 3.3 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.7 2.9 GO:0016652 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.5 2.7 GO:0070573 metallodipeptidase activity(GO:0070573)
0.4 1.2 GO:0003994 aconitate hydratase activity(GO:0003994)
0.4 3.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.4 1.2 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.3 6.9 GO:0030515 snoRNA binding(GO:0030515)
0.3 1.6 GO:0070412 R-SMAD binding(GO:0070412)
0.3 16.7 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.3 1.9 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.3 1.2 GO:0001596 angiotensin type I receptor activity(GO:0001596) angiotensin type II receptor activity(GO:0004945)
0.3 1.2 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.3 2.7 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.2 5.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 2.4 GO:0008172 S-methyltransferase activity(GO:0008172)
0.2 0.7 GO:1990715 mRNA CDS binding(GO:1990715) sequence-specific mRNA binding(GO:1990825)
0.2 1.9 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.2 7.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.2 0.7 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.2 8.0 GO:0005518 collagen binding(GO:0005518)
0.2 3.7 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.2 0.6 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.2 1.0 GO:0030620 U2 snRNA binding(GO:0030620)
0.2 0.6 GO:0050649 testosterone 6-beta-hydroxylase activity(GO:0050649)
0.2 0.6 GO:0004904 interferon receptor activity(GO:0004904)
0.2 2.8 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.2 0.9 GO:0039706 co-receptor binding(GO:0039706)
0.2 1.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.2 6.1 GO:0017147 Wnt-protein binding(GO:0017147)
0.2 0.7 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.2 1.7 GO:0000048 peptidyltransferase activity(GO:0000048) glutathione hydrolase activity(GO:0036374)
0.2 0.6 GO:1901612 cardiolipin binding(GO:1901612)
0.2 1.6 GO:0015250 water channel activity(GO:0015250)
0.2 0.9 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.2 1.2 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.2 1.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.2 0.6 GO:0052905 tRNA (guanine(9)-N(1))-methyltransferase activity(GO:0052905)
0.2 0.5 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.2 0.5 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.2 2.2 GO:0031369 translation initiation factor binding(GO:0031369)
0.2 1.7 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.2 1.1 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.1 0.4 GO:0071885 N-terminal protein N-methyltransferase activity(GO:0071885)
0.1 1.2 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.1 0.4 GO:0005093 Rab GDP-dissociation inhibitor activity(GO:0005093)
0.1 1.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 0.4 GO:0004774 succinate-CoA ligase activity(GO:0004774) succinate-CoA ligase (ADP-forming) activity(GO:0004775) succinate-CoA ligase (GDP-forming) activity(GO:0004776)
0.1 0.8 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.1 1.3 GO:0051373 telethonin binding(GO:0031433) FATZ binding(GO:0051373)
0.1 2.6 GO:0051393 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.1 0.5 GO:0004998 transferrin receptor activity(GO:0004998)
0.1 0.7 GO:0048156 tau protein binding(GO:0048156)
0.1 0.5 GO:0033745 L-methionine-(R)-S-oxide reductase activity(GO:0033745)
0.1 0.7 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.1 1.1 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 0.6 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 0.4 GO:0005471 ATP:ADP antiporter activity(GO:0005471)
0.1 0.3 GO:0043185 vascular endothelial growth factor receptor 3 binding(GO:0043185)
0.1 1.0 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.3 GO:0004557 alpha-galactosidase activity(GO:0004557)
0.1 6.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 1.1 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 2.5 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.9 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 0.3 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.1 3.7 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 0.4 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.1 1.0 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1 1.3 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.1 3.0 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 0.3 GO:0048030 disaccharide binding(GO:0048030)
0.1 0.8 GO:0005042 netrin receptor activity(GO:0005042)
0.1 0.2 GO:0016496 substance P receptor activity(GO:0016496)
0.1 1.5 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 4.8 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 1.0 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1 0.3 GO:0048487 beta-tubulin binding(GO:0048487)
0.1 2.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 2.0 GO:0015248 sterol transporter activity(GO:0015248)
0.1 1.1 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 0.3 GO:0061656 SUMO conjugating enzyme activity(GO:0061656)
0.1 1.5 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 1.3 GO:0072542 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.1 0.9 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 1.2 GO:0035497 cAMP response element binding(GO:0035497)
0.1 0.4 GO:0004962 endothelin receptor activity(GO:0004962)
0.1 0.7 GO:0008199 ferric iron binding(GO:0008199)
0.1 0.3 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 0.2 GO:0032138 guanine/thymine mispair binding(GO:0032137) single base insertion or deletion binding(GO:0032138) single thymine insertion binding(GO:0032143) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357) mismatch repair complex binding(GO:0032404) MutLalpha complex binding(GO:0032405)
0.1 0.4 GO:0036122 BMP binding(GO:0036122)
0.1 0.4 GO:0030274 LIM domain binding(GO:0030274)
0.1 0.8 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 0.8 GO:0022884 protein transmembrane transporter activity(GO:0008320) macromolecule transmembrane transporter activity(GO:0022884)
0.1 0.2 GO:0070097 delta-catenin binding(GO:0070097)
0.1 1.6 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 1.1 GO:0048185 activin binding(GO:0048185)
0.1 0.4 GO:0015157 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.1 0.9 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 4.8 GO:0008201 heparin binding(GO:0008201)
0.1 0.7 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 0.7 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.5 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 6.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.2 GO:0004379 glycylpeptide N-tetradecanoyltransferase activity(GO:0004379)
0.0 0.8 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.6 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.8 GO:0004382 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.0 1.2 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 1.0 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0031704 apelin receptor binding(GO:0031704)
0.0 1.4 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.4 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.9 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.4 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.2 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.4 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.2 GO:0033781 cholesterol 24-hydroxylase activity(GO:0033781)
0.0 1.1 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.2 GO:0017020 myosin phosphatase regulator activity(GO:0017020)
0.0 0.3 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 2.6 GO:0003823 antigen binding(GO:0003823)
0.0 4.3 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.6 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.2 GO:0050254 rhodopsin kinase activity(GO:0050254)
0.0 1.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.2 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 2.3 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.5 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 0.3 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.4 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.1 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
0.0 1.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.1 GO:0050211 procollagen galactosyltransferase activity(GO:0050211)
0.0 0.3 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.3 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.1 GO:0052725 inositol tetrakisphosphate 1-kinase activity(GO:0047325) inositol-1,3,4-trisphosphate 6-kinase activity(GO:0052725) inositol-1,3,4-trisphosphate 5-kinase activity(GO:0052726)
0.0 0.1 GO:0048019 receptor antagonist activity(GO:0048019)
0.0 0.7 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.2 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.6 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 2.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.2 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.3 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.0 0.4 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.5 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0033764)
0.0 0.4 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 2.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:0033897 ribonuclease T2 activity(GO:0033897)
0.0 1.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.2 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.2 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.1 GO:0004471 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.0 0.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.2 GO:0016433 rRNA (adenine) methyltransferase activity(GO:0016433)
0.0 0.1 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
0.0 0.4 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.4 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 1.6 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.1 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.2 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.3 GO:0002039 p53 binding(GO:0002039)
0.0 0.2 GO:0004100 chitin synthase activity(GO:0004100)
0.0 0.7 GO:0004180 carboxypeptidase activity(GO:0004180)
0.0 0.3 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828)
0.0 0.9 GO:0005109 frizzled binding(GO:0005109)
0.0 0.2 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 0.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.1 GO:0070888 E-box binding(GO:0070888)
0.0 0.1 GO:0004174 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.0 0.1 GO:0004859 phospholipase inhibitor activity(GO:0004859) lipase inhibitor activity(GO:0055102)
0.0 0.2 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0004104 cholinesterase activity(GO:0004104)
0.0 0.3 GO:2001069 glycogen binding(GO:2001069)
0.0 2.2 GO:0004620 phospholipase activity(GO:0004620)
0.0 0.3 GO:0015026 coreceptor activity(GO:0015026)
0.0 1.0 GO:0004601 peroxidase activity(GO:0004601)
0.0 0.2 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 0.1 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.2 GO:0002020 protease binding(GO:0002020)
0.0 1.3 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 3.7 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.9 GO:0030414 peptidase inhibitor activity(GO:0030414)
0.0 0.1 GO:0004974 leukotriene receptor activity(GO:0004974)
0.0 0.2 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0 0.0 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 0.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.1 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.0 0.1 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.1 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.1 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.4 GO:0008235 metalloexopeptidase activity(GO:0008235)
0.0 0.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.0 GO:0016657 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.0 0.1 GO:0010436 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.0 0.6 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.1 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.2 GO:0051117 ATPase binding(GO:0051117)
0.0 0.2 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.3 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 6.0 GO:0005198 structural molecule activity(GO:0005198)
0.0 0.2 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.2 GO:0019903 protein phosphatase binding(GO:0019903)
0.0 0.9 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.8 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 1.1 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 0.5 GO:0042562 hormone binding(GO:0042562)
0.0 6.0 GO:0005525 GTP binding(GO:0005525)
0.0 0.1 GO:0042910 xenobiotic transporter activity(GO:0042910)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 8.1 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.3 10.2 NABA COLLAGENS Genes encoding collagen proteins
0.2 0.7 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.2 6.9 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.2 0.6 PID FAS PATHWAY FAS (CD95) signaling pathway
0.2 6.6 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.2 1.0 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.1 5.1 PID NETRIN PATHWAY Netrin-mediated signaling events
0.1 0.7 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.1 1.6 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 0.2 PID INSULIN PATHWAY Insulin Pathway
0.1 0.6 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 0.9 PID GLYPICAN 1PATHWAY Glypican 1 network
0.1 12.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 0.9 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.1 1.3 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 1.7 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.1 0.8 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 0.5 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.1 0.5 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.1 9.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 0.9 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.1 1.2 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.1 2.7 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.9 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 1.0 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.0 0.7 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.4 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.4 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.3 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.8 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.3 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.4 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 1.5 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.1 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.4 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.8 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.2 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.2 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 0.3 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.4 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 0.2 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.5 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.1 PID IL23 PATHWAY IL23-mediated signaling events
0.0 1.8 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.2 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.4 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.4 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.3 PID RAC1 PATHWAY RAC1 signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.5 6.3 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.3 3.6 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.3 1.4 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.2 10.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.2 6.2 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.2 5.3 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 4.1 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.0 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 0.8 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 0.4 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 2.8 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.1 2.4 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 5.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 1.9 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1 0.8 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 0.5 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 0.9 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 0.4 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.1 1.1 REACTOME SHC MEDIATED SIGNALLING Genes involved in SHC-mediated signalling
0.1 1.2 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 0.8 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 4.4 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 2.8 REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.1 0.2 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.1 0.7 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 0.6 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 1.0 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 0.9 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 5.5 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 1.6 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.4 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 1.2 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.7 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.3 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 0.5 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 2.2 REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE Genes involved in MyD88:Mal cascade initiated on plasma membrane
0.0 3.2 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.2 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.2 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.2 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.7 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0 1.3 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.0 0.9 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.8 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.2 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.5 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.7 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 1.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.3 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.7 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.2 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.2 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.0 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.3 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism