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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for snai1b+snai3

Z-value: 0.58

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Transcription factors associated with snai1b+snai3

Gene Symbol Gene ID Gene Info
snai3
ENSDARG00000031243 snail family zinc finger 3
snai1b
ENSDARG00000046019 snail family zinc finger 1b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
snai3dr11_v1_chr7_+_55112922_551129220.205.1e-02Click!
snai1bdr11_v1_chr23_-_2513300_2513300-0.141.8e-01Click!

Activity profile of snai1b+snai3 motif

Sorted Z-values of snai1b+snai3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr23_+_32039386 4.95 ENSDART00000133801
mylk2
myosin light chain kinase 2
chr13_-_37180815 4.17 ENSDART00000139907
si:dkeyp-77c8.1
si:dkeyp-77c8.1
chr12_+_30586599 3.53 ENSDART00000124920
ENSDART00000126984
nrap
nebulin-related anchoring protein
chr13_+_23157053 3.48 ENSDART00000162359
sorbs1
sorbin and SH3 domain containing 1
chr6_-_10788065 2.72 ENSDART00000190968
wipf1b
WAS/WASL interacting protein family, member 1b
chr5_+_6670945 2.56 ENSDART00000185686
pxna
paxillin a
chr14_+_15155684 2.51 ENSDART00000167966
zgc:158852
zgc:158852
chr10_+_1052591 2.49 ENSDART00000123405
unc5c
unc-5 netrin receptor C
chr20_-_9436521 2.43 ENSDART00000133000
zgc:101840
zgc:101840
chr4_-_78026285 2.35 ENSDART00000168273
CCT2
chaperonin containing TCP1 subunit 2
chr10_-_33588106 2.27 ENSDART00000155634
eva1c
eva-1 homolog C (C. elegans)
chr21_-_43666420 2.14 ENSDART00000139008
ENSDART00000183996
ENSDART00000183395
si:dkey-229d11.3
si:dkey-229d11.5
si:dkey-229d11.3
si:dkey-229d11.5
chr25_+_5249513 1.97 ENSDART00000126814
CABZ01039863.1

chr22_-_14128716 1.93 ENSDART00000140323
si:ch211-246m6.4
si:ch211-246m6.4
chr20_-_23426339 1.92 ENSDART00000004625
zar1
zygote arrest 1
chr25_-_169291 1.88 ENSDART00000128344
lipcb
lipase, hepatic b
chr19_-_35439237 1.64 ENSDART00000145883
anln
anillin, actin binding protein
chr20_-_43743700 1.64 ENSDART00000100620
si:dkeyp-50f7.2
si:dkeyp-50f7.2
chr1_-_55058795 1.60 ENSDART00000187293
peli1a
pellino E3 ubiquitin protein ligase 1a
chr22_+_20560041 1.58 ENSDART00000135490
nfil3-4
nuclear factor, interleukin 3 regulated, member 4
chr7_+_58751504 1.53 ENSDART00000024185
zgc:56231
zgc:56231
chr2_-_10896745 1.53 ENSDART00000114609
cdcp2
CUB domain containing protein 2
chr14_-_26482096 1.45 ENSDART00000187280
smad5
SMAD family member 5
chr10_-_13116337 1.44 ENSDART00000164568
musk
muscle, skeletal, receptor tyrosine kinase
chr7_-_45990681 1.39 ENSDART00000165441
si:ch211-260e23.7
si:ch211-260e23.7
chr1_-_43892349 1.39 ENSDART00000148416
tacr3a
tachykinin receptor 3a
chr10_+_24445698 1.38 ENSDART00000146370
slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr17_-_11151655 1.37 ENSDART00000156383
CU179699.1

chr20_-_21672970 1.36 ENSDART00000133286
si:ch211-207i1.2
si:ch211-207i1.2
chr23_+_34047413 1.36 ENSDART00000143933
ENSDART00000123925
ENSDART00000176139
chchd6a
coiled-coil-helix-coiled-coil-helix domain containing 6a
chr1_+_524717 1.33 ENSDART00000102421
ENSDART00000184473
mrpl16
mitochondrial ribosomal protein L16
chr20_-_52902693 1.29 ENSDART00000166115
ENSDART00000161050
ctsbb
cathepsin Bb
chr19_+_142270 1.26 ENSDART00000160201
tnfrsf11b
tumor necrosis factor receptor superfamily, member 11b
chr2_-_49997055 1.21 ENSDART00000140294
si:ch211-106n13.3
si:ch211-106n13.3
chr25_-_16076257 1.19 ENSDART00000140780
ovch2
ovochymase 2
chr18_+_33580660 1.19 ENSDART00000139117
si:dkey-47k20.4
si:dkey-47k20.4
chr20_-_1314355 1.18 ENSDART00000152436
pcmt
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr22_-_209741 1.15 ENSDART00000171954
ora1
olfactory receptor class A related 1
chr4_-_12790886 1.14 ENSDART00000182535
ENSDART00000067131
ENSDART00000186426
irak3
interleukin-1 receptor-associated kinase 3
chr18_+_27821856 1.13 ENSDART00000131712
si:ch211-222m18.4
si:ch211-222m18.4
chr5_-_22052852 1.11 ENSDART00000002938
mtmr8
myotubularin related protein 8
chr21_+_19858627 1.10 ENSDART00000147010
fybb
FYN binding protein b
chr13_-_36579086 1.07 ENSDART00000146671
lgals3a
lectin, galactoside binding soluble 3a
chr3_-_34052882 1.05 ENSDART00000151463
ighv11-1
immunoglobulin heavy variable 11-1
chr24_+_19578935 1.02 ENSDART00000137175
sulf1
sulfatase 1
chr5_-_26181863 1.01 ENSDART00000098500
ccdc125
coiled-coil domain containing 125
chr7_-_50367326 0.99 ENSDART00000141926
prc1b
protein regulator of cytokinesis 1b
chr13_+_35955562 0.92 ENSDART00000137377
si:ch211-67f13.7
si:ch211-67f13.7
chr23_-_29824146 0.90 ENSDART00000020616
zgc:194189
zgc:194189
chr22_-_17677947 0.87 ENSDART00000139911
tjp3
tight junction protein 3
chr6_+_39905021 0.86 ENSDART00000064904
endou
endonuclease, polyU-specific
chr9_-_28255029 0.86 ENSDART00000160387
ccnyl1
cyclin Y-like 1
chr18_-_37241080 0.83 ENSDART00000126421
ENSDART00000078064
six9
SIX homeobox 9
chr24_+_9372292 0.77 ENSDART00000082422
ENSDART00000191127
ENSDART00000180510
si:ch211-285f17.1
si:ch211-285f17.1
chr10_+_37173029 0.76 ENSDART00000136510
ksr1a
kinase suppressor of ras 1a
chr7_-_50367642 0.75 ENSDART00000134941
prc1b
protein regulator of cytokinesis 1b
chr8_-_13029297 0.75 ENSDART00000144305
dennd2da
DENN/MADD domain containing 2Da
chr14_-_38865800 0.74 ENSDART00000173047
gsr
glutathione reductase
chr7_+_30926289 0.74 ENSDART00000173518
si:dkey-1h4.4
si:dkey-1h4.4
chr6_-_130849 0.74 ENSDART00000108710
LRRC8E
si:zfos-323e3.4
chr23_-_44219902 0.71 ENSDART00000185874
zgc:158659
zgc:158659
chr9_-_11549379 0.71 ENSDART00000187074
fev
FEV (ETS oncogene family)
chr4_-_16341801 0.70 ENSDART00000140190
kera
keratocan
chr10_-_8358396 0.70 ENSDART00000059322
csgalnact1a
chondroitin sulfate N-acetylgalactosaminyltransferase 1a
chr22_+_7439186 0.69 ENSDART00000190667
zgc:92041
zgc:92041
chr22_+_22438783 0.69 ENSDART00000147825
kif14
kinesin family member 14
chr25_+_5012791 0.68 ENSDART00000156970
si:ch73-265h17.5
si:ch73-265h17.5
chr9_-_849069 0.68 ENSDART00000136091
c1ql2
complement component 1, q subcomponent-like 2
chr10_-_38468847 0.67 ENSDART00000133914
gdpd5a
glycerophosphodiester phosphodiesterase domain containing 5a
chr25_-_17395315 0.66 ENSDART00000064596
cyp2x8
cytochrome P450, family 2, subfamily X, polypeptide 8
chr14_-_28052474 0.66 ENSDART00000172948
ENSDART00000135337
TSC22D3 (1 of many)
zgc:64189
si:ch211-220e11.3
zgc:64189
chr23_-_24047054 0.64 ENSDART00000184308
ENSDART00000185902
CR925720.1

chr13_-_9119867 0.62 ENSDART00000137255
si:dkey-112g5.15
si:dkey-112g5.15
chr6_-_10728057 0.60 ENSDART00000002247
sp3b
Sp3b transcription factor
chr15_-_434503 0.57 ENSDART00000122286
CABZ01056629.1

chr18_+_45666489 0.56 ENSDART00000180147
ENSDART00000151351
prrg4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr8_-_34762163 0.56 ENSDART00000114080
setd1bb
SET domain containing 1B, b
chr24_-_25184553 0.56 ENSDART00000166917
plcxd2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr7_+_42328578 0.55 ENSDART00000149082
phkb
phosphorylase kinase, beta
chr2_+_5948534 0.54 ENSDART00000124324
ENSDART00000176461
slc1a7a
solute carrier family 1 (glutamate transporter), member 7a
chr17_+_1360192 0.54 ENSDART00000184561
siva1
SIVA1, apoptosis-inducing factor
chr9_+_331425 0.51 ENSDART00000170312
actr5
ARP5 actin related protein 5 homolog
chr3_+_23029934 0.50 ENSDART00000110343
nags
N-acetylglutamate synthase
chr11_+_6902946 0.47 ENSDART00000144006
crtc1b
CREB regulated transcription coactivator 1b
chr11_+_40831620 0.46 ENSDART00000160023
errfi1a
ERBB receptor feedback inhibitor 1a
chr8_+_247163 0.44 ENSDART00000122378
cep120
centrosomal protein 120
chr4_-_36476889 0.43 ENSDART00000163956
si:ch211-263l8.1
si:ch211-263l8.1
chr1_-_21909608 0.42 ENSDART00000139937
frmpd1a
FERM and PDZ domain containing 1a
chr15_-_42736433 0.42 ENSDART00000154379
si:ch211-181d7.1
si:ch211-181d7.1
chr22_-_8910567 0.41 ENSDART00000187896
ENSDART00000188511
ENSDART00000175764
FO393424.2

chr12_-_46112892 0.41 ENSDART00000187128
ENSDART00000114268
zgc:153932
zgc:153932
chr2_+_9536021 0.40 ENSDART00000187357
CU929379.1

chr20_+_42978499 0.39 ENSDART00000138793
si:ch211-203k16.3
si:ch211-203k16.3
chr22_-_18546649 0.39 ENSDART00000171277
cirbpb
cold inducible RNA binding protein b
chr4_+_54645654 0.37 ENSDART00000192864
si:ch211-227e10.1
si:ch211-227e10.1
chr5_+_53482597 0.36 ENSDART00000180333
BX323994.1

chr12_+_48784731 0.36 ENSDART00000158348
zmiz1b
zinc finger, MIZ-type containing 1b
chr21_-_41873584 0.30 ENSDART00000188089
endou2
endonuclease, polyU-specific 2
chr13_+_2448251 0.23 ENSDART00000188361
arfgef3
ARFGEF family member 3
chr7_-_58867188 0.22 ENSDART00000187006
CU681855.1

chr21_+_30794351 0.17 ENSDART00000139486
zgc:158225
zgc:158225
chr2_-_42628028 0.16 ENSDART00000179866
myo10
myosin X
chr3_+_56276346 0.15 ENSDART00000157770
PRKCA
si:ch73-374l24.1
chr10_+_9601587 0.13 ENSDART00000147997
rc3h2
ring finger and CCCH-type domains 2
chr11_-_8782871 0.13 ENSDART00000158546
si:ch211-51h4.2
si:ch211-51h4.2
chr8_-_10949847 0.13 ENSDART00000123209
pqlc2
PQ loop repeat containing 2
chr2_-_722156 0.11 ENSDART00000045770
ENSDART00000169498
foxq1a
forkhead box Q1a
chr10_-_94184 0.07 ENSDART00000146125
ttc3
tetratricopeptide repeat domain 3
chr22_-_17256573 0.04 ENSDART00000136119
ENSDART00000062891
nphs2
nephrosis 2, idiopathic, steroid-resistant (podocin)
chr18_+_33580391 0.00 ENSDART00000189300
si:dkey-47k20.4
si:dkey-47k20.4

Network of associatons between targets according to the STRING database.

First level regulatory network of snai1b+snai3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.5 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
0.4 1.6 GO:0008356 asymmetric cell division(GO:0008356)
0.4 1.1 GO:0032640 tumor necrosis factor production(GO:0032640) tumor necrosis factor superfamily cytokine production(GO:0071706)
0.3 1.6 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
0.2 3.6 GO:0061055 myotome development(GO:0061055)
0.2 2.5 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.2 1.1 GO:0048245 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.2 1.4 GO:1902093 positive regulation of sperm motility(GO:1902093)
0.2 1.4 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.2 0.9 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.2 1.7 GO:0000022 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231) mitotic spindle midzone assembly(GO:0051256)
0.1 0.5 GO:0006526 arginine biosynthetic process(GO:0006526)
0.1 1.9 GO:0019433 triglyceride catabolic process(GO:0019433)
0.1 0.4 GO:0010825 positive regulation of centrosome duplication(GO:0010825)
0.1 1.1 GO:0007608 sensory perception of smell(GO:0007608)
0.1 1.5 GO:2000223 regulation of BMP signaling pathway involved in heart jogging(GO:2000223)
0.1 0.9 GO:0030104 water homeostasis(GO:0030104)
0.1 1.4 GO:0042407 cristae formation(GO:0042407)
0.1 0.7 GO:0071684 hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.1 1.0 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.1 0.5 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.1 0.5 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.1 0.9 GO:0007339 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.1 1.4 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.7 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 1.1 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 1.3 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.7 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 2.6 GO:0030048 actin filament-based movement(GO:0030048)
0.0 0.7 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.4 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.6 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.4 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 1.1 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 1.0 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 1.9 GO:0017148 negative regulation of translation(GO:0017148)
0.0 0.7 GO:0051057 positive regulation of Ras protein signal transduction(GO:0046579) positive regulation of small GTPase mediated signal transduction(GO:0051057)
0.0 1.3 GO:0009612 response to mechanical stimulus(GO:0009612)
0.0 1.6 GO:0007623 circadian rhythm(GO:0007623)
0.0 0.7 GO:0042738 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.6 GO:0005826 actomyosin contractile ring(GO:0005826)
0.2 1.4 GO:0097225 sperm midpiece(GO:0097225)
0.1 1.7 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 1.1 GO:0001772 immunological synapse(GO:0001772)
0.1 1.9 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 1.4 GO:0061617 MICOS complex(GO:0061617)
0.1 1.4 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 1.5 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 0.7 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.5 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 3.5 GO:0030018 Z disc(GO:0030018)
0.0 0.5 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.6 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 1.3 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 2.2 GO:0005871 kinesin complex(GO:0005871)
0.0 2.5 GO:0005884 actin filament(GO:0005884)
0.0 2.6 GO:0005925 focal adhesion(GO:0005925)
0.0 1.0 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 1.7 GO:0005795 Golgi stack(GO:0005795)
0.0 1.2 GO:0005581 collagen trimer(GO:0005581)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0034185 apolipoprotein binding(GO:0034185)
0.4 1.1 GO:0072545 tyrosine binding(GO:0072545)
0.4 5.0 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.2 2.5 GO:0005042 netrin receptor activity(GO:0005042)
0.2 1.1 GO:0019863 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
0.2 1.4 GO:0004995 tachykinin receptor activity(GO:0004995)
0.2 1.2 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.2 1.4 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.1 0.7 GO:0004362 glutathione-disulfide reductase activity(GO:0004362)
0.1 0.4 GO:0034618 arginine binding(GO:0034618)
0.1 1.1 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 0.7 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.1 1.5 GO:0070411 I-SMAD binding(GO:0070411)
0.1 0.5 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.7 GO:0052812 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.1 1.0 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.9 GO:0032190 acrosin binding(GO:0032190)
0.0 1.3 GO:0019843 rRNA binding(GO:0019843)
0.0 2.3 GO:0008201 heparin binding(GO:0008201)
0.0 1.0 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.1 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 2.2 GO:0003777 microtubule motor activity(GO:0003777)
0.0 1.2 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 0.9 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 5.1 GO:0051015 actin filament binding(GO:0051015)
0.0 0.5 GO:0032813 tumor necrosis factor receptor superfamily binding(GO:0032813)
0.0 0.7 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 0.4 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 1.5 PID ALK2 PATHWAY ALK2 signaling events
0.1 2.7 PID NETRIN PATHWAY Netrin-mediated signaling events
0.1 1.8 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 3.5 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 1.1 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.2 PID VEGFR1 PATHWAY VEGFR1 specific signals

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.5 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 2.3 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1 1.5 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 2.7 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 0.7 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.4 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.5 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.7 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 1.1 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine