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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for sox10

Z-value: 1.04

Motif logo

Transcription factors associated with sox10

Gene Symbol Gene ID Gene Info
ENSDARG00000077467 SRY-box transcription factor 10

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
sox10dr11_v1_chr3_+_1492174_1492174-0.741.1e-17Click!

Activity profile of sox10 motif

Sorted Z-values of sox10 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_3629201 23.54 ENSDART00000136577
ENSDART00000132121
inter-alpha-trypsin inhibitor heavy chain 3a
chr2_-_39017838 19.87 ENSDART00000048838
retinol binding protein 2b, cellular
chr1_-_19845378 15.38 ENSDART00000139314
ENSDART00000132958
ENSDART00000147502
glyoxylate reductase/hydroxypyruvate reductase b
chr15_-_108414 13.74 ENSDART00000170044
apolipoprotein A-Ib
chr20_-_25518488 12.30 ENSDART00000186993
cytochrome P450, family 2, subfamily N, polypeptide 13
chr16_-_45917322 11.33 ENSDART00000060822
antifreeze protein type IV
chr22_-_23591493 10.73 ENSDART00000170266
coagulation factor XIII, B polypeptide
chr21_+_20771082 10.62 ENSDART00000079732
3-oxoacid CoA transferase 1b
chr5_+_28849155 10.54 ENSDART00000079090
zgc:174259
chr5_+_28848870 10.54 ENSDART00000149563
zgc:174259
chr8_-_50147948 10.19 ENSDART00000149010
haptoglobin
chr22_-_23591340 10.09 ENSDART00000167024
coagulation factor XIII, B polypeptide
chr2_-_43653328 9.28 ENSDART00000037808
integrin, beta 1b.2
chr21_-_25756119 9.21 ENSDART00000002341
claudin c
chr15_-_32365940 8.81 ENSDART00000155371
complement component 4
chr23_+_17981127 8.67 ENSDART00000012571
ENSDART00000145200
chitinase, acidic.6
chr8_-_50482781 7.75 ENSDART00000056361
indoleamine 2,3-dioxygenase 1
chr10_-_25823258 7.53 ENSDART00000064327
finTRIM family, member 54
chr3_-_18030938 7.42 ENSDART00000013540
si:ch73-141c7.1
chr18_+_40462445 7.26 ENSDART00000087645
UDP glucuronosyltransferase 5 family, polypeptide C2
chr21_-_40083432 7.20 ENSDART00000141160
ENSDART00000191195
info solute carrier family 13 (sodium-dependent citrate transporter), member 5a
chr2_-_20052561 7.17 ENSDART00000100133
dihydropyrimidine dehydrogenase b
chr12_-_36045283 6.43 ENSDART00000160646
G protein-coupled receptor, class C, group 5, member C
chr23_+_10352921 6.19 ENSDART00000081193
si:ch211-133j6.3
chr6_-_23931442 5.96 ENSDART00000160547
SEC16 homolog B, endoplasmic reticulum export factor
chr8_-_38201415 5.88 ENSDART00000155189
PDZ and LIM domain 2 (mystique)
chr24_-_2843107 5.60 ENSDART00000165290
cytochrome b5 type A (microsomal)
chr7_-_53117131 5.58 ENSDART00000169211
ENSDART00000168890
ENSDART00000172179
ENSDART00000167882
cadherin 1, type 1, E-cadherin (epithelial)
chr16_+_26732086 5.47 ENSDART00000138496
RAD54 homolog B (S. cerevisiae)
chr3_+_15505275 5.42 ENSDART00000141714
nuclear protein 1
chr5_-_20123002 5.38 ENSDART00000026516
peroxisomal membrane protein 2
chr9_+_8396755 5.37 ENSDART00000043067
zgc:171776
chr8_+_39802506 5.25 ENSDART00000018862
HNF1 homeobox a
chr1_-_33645967 4.92 ENSDART00000192758
claudin g
chr14_+_15155684 4.92 ENSDART00000167966
zgc:158852
chr16_-_26731928 4.79 ENSDART00000135860
ring finger protein 41, like
chr4_-_77432218 4.79 ENSDART00000158683
solute carrier organic anion transporter family, member 1D1
chr7_+_38255418 4.46 ENSDART00000052354
si:dkey-78a14.4
chr6_+_30456788 4.42 ENSDART00000121492

chr4_+_25607743 4.41 ENSDART00000028297
acyl-CoA thioesterase 14
chr7_+_49664174 4.40 ENSDART00000137059
ENSDART00000131210
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7b
chr16_-_41762983 4.38 ENSDART00000192936
si:dkey-199f5.8
chr9_-_29497916 4.25 ENSDART00000060246
DnaJ (Hsp40) homolog, subfamily C, member 3a
chr25_+_16880990 4.21 ENSDART00000020259
zgc:77158
chr16_+_19637384 4.19 ENSDART00000184773
ENSDART00000191895
ENSDART00000182020
ENSDART00000135359
metastasis associated in colon cancer 1
chr19_-_27588842 4.19 ENSDART00000121643
si:dkeyp-46h3.2
chr13_+_33651416 4.05 ENSDART00000180221

chr24_+_10027902 4.04 ENSDART00000175961
ENSDART00000172773
si:ch211-146l10.8
chr20_-_43775495 4.03 ENSDART00000100610
ENSDART00000149001
ENSDART00000148809
ENSDART00000100608
matrilin 3a
chr16_-_25607266 4.00 ENSDART00000192602
zgc:110410
chr16_+_40560622 3.93 ENSDART00000038294
tumor protein p53 inducible nuclear protein 1
chr7_-_71531846 3.90 ENSDART00000111797
alkaline ceramidase 2
chr25_+_11281970 3.88 ENSDART00000180094
si:dkey-187e18.1
chr3_-_16250527 3.79 ENSDART00000146699
ENSDART00000141181
branched chain keto acid dehydrogenase E1, beta polypeptide, like
chr5_+_44846434 3.69 ENSDART00000145299
ENSDART00000136521
KN motif and ankyrin repeat domains 1a
chr14_+_46313135 3.62 ENSDART00000172902
crystallin, beta A1, like 1
chr6_-_39313027 3.61 ENSDART00000012644
keratin 4
chr15_-_34418525 3.58 ENSDART00000147582
alkylglycerol monooxygenase
chr17_-_25737452 3.55 ENSDART00000152021
si:ch211-214p16.3
chr23_-_31506854 3.53 ENSDART00000131352
ENSDART00000138625
ENSDART00000133002
EYA transcriptional coactivator and phosphatase 4
chr10_+_9550419 3.50 ENSDART00000064977
si:ch211-243g18.2
chr1_+_12178215 3.49 ENSDART00000090380
STRA6-like
chr22_+_1028724 3.47 ENSDART00000149625
si:ch73-352p18.4
chr5_-_42894068 3.46 ENSDART00000169606
chemokine (C-X-C motif) ligand 11, duplicate 1
chr10_+_16501699 3.42 ENSDART00000121864
solute carrier family 27 (fatty acid transporter), member 6
chr12_-_3237561 3.36 ENSDART00000164665
si:ch1073-13h15.3
chr11_-_10659195 3.34 ENSDART00000115255
MCF.2 cell line derived transforming sequence-like 2
chr15_-_36365840 3.32 ENSDART00000192926
si:dkey-23k10.3
chr23_+_36063599 3.31 ENSDART00000103147
homeobox C12a
chr23_+_36144487 3.28 ENSDART00000082473
homeobox C3a
chr22_-_16180849 3.26 ENSDART00000090390
vascular cell adhesion molecule 1b
chr22_-_10541372 3.24 ENSDART00000179708
si:dkey-42i9.4
chr1_+_32051581 3.18 ENSDART00000146602
steroid sulfatase (microsomal), isozyme S
chr18_-_14836862 3.14 ENSDART00000124843
metastasis suppressor 1-like a
chr15_-_17870090 3.12 ENSDART00000155066
activating transcription factor 5b
chr7_-_39552314 3.09 ENSDART00000134174
solute carrier family 22, member 18
chr10_-_40543896 3.09 ENSDART00000186921
ENSDART00000136031
trace amine associated receptor 18f
chr10_+_7703251 3.07 ENSDART00000165134
gamma-glutamyl carboxylase
chr17_+_24064014 3.01 ENSDART00000182782
ENSDART00000139063
ENSDART00000132755
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2b
chr14_+_16036139 3.00 ENSDART00000190733
PRELI domain containing 1a
chr17_-_20236228 2.99 ENSDART00000136490
ENSDART00000029380
BCL2 interacting protein 4
chr14_-_33348221 2.99 ENSDART00000187749
ribosomal protein L39
chr3_+_17933553 2.99 ENSDART00000167731
ENSDART00000165644
2',3'-cyclic nucleotide 3' phosphodiesterase
chr8_+_17869225 2.94 ENSDART00000080079
solute carrier family 44, member 5b
chr20_+_25568694 2.93 ENSDART00000063107
ENSDART00000063128
cytochrome P450, family 2, subfamily P, polypeptide 7
chr15_+_22390076 2.93 ENSDART00000183764
OAF homolog a (Drosophila)
chr20_-_40360571 2.90 ENSDART00000144768
sphingomyelin phosphodiesterase, acid-like 3A
chr19_+_31044487 2.89 ENSDART00000143494
ankyrin repeat and MYND domain containing 2b
chr19_+_7636941 2.87 ENSDART00000081611
ENSDART00000163805
ENSDART00000112404
cingulin b
chr22_-_38274188 2.86 ENSDART00000139420
ENSDART00000015117
ELAV like neuron-specific RNA binding protein 2
chr9_+_15893093 2.83 ENSDART00000099483
ENSDART00000134657
si:dkey-14o1.20
chr3_-_34069637 2.82 ENSDART00000151588
immunoglobulin heavy variable 9-1
chr11_+_12052791 2.78 ENSDART00000158479
si:ch211-156l18.8
chr22_+_1911269 2.74 ENSDART00000164158
ENSDART00000168205
zinc finger protein 1156
chr1_+_38858399 2.71 ENSDART00000165454

chr5_+_26121393 2.71 ENSDART00000002221
beta-carotene 15, 15-dioxygenase 2, like
chr15_+_31481939 2.70 ENSDART00000134306
odorant receptor, family C, subfamily 102, member 5
chr11_+_29965822 2.70 ENSDART00000127049
interleukin-1 family member A
chr15_-_39955785 2.69 ENSDART00000154556
mutS homolog 5
chr16_+_19029297 2.68 ENSDART00000115263
ENSDART00000114954
Rap guanine nucleotide exchange factor (GEF) 5b
chr24_-_26369185 2.67 ENSDART00000080039
leucine rich repeat containing 31
chr7_+_24814866 2.66 ENSDART00000173581
si:ch211-226l4.6
chr20_-_54014539 2.65 ENSDART00000060466
si:dkey-241l7.6
chr9_+_11293830 2.65 ENSDART00000144440
wingless-type MMTV integration site family, member 6b
chr14_-_24101897 2.62 ENSDART00000143695
cytoplasmic polyadenylation element binding protein 4a
chr12_-_42368296 2.61 ENSDART00000171075
zgc:111868
chr19_-_4785734 2.60 ENSDART00000113088
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr24_-_22003031 2.59 ENSDART00000133627
si:rp71-1f1.5
chr25_+_35058088 2.57 ENSDART00000156838
zgc:112234
chr3_-_24458281 2.56 ENSDART00000153993
BAI1-associated protein 2-like 2a
chr17_-_6599484 2.54 ENSDART00000156927
si:ch211-189e2.2
chr17_+_30546579 2.54 ENSDART00000154385
NHS-like 1a
chr16_+_29586468 2.50 ENSDART00000148926
MCL1, BCL2 family apoptosis regulator b
chr9_+_23003208 2.50 ENSDART00000021060
ELL associated factor 2
chr7_-_6459481 2.48 ENSDART00000173158
zgc:112234
chr7_+_61184104 2.48 ENSDART00000110671
zgc:194930
chr16_+_42465518 2.45 ENSDART00000058699
si:ch211-215k15.4
chr22_+_25774750 2.45 ENSDART00000174421

chr3_-_9488350 2.45 ENSDART00000186707

chr2_+_19522082 2.45 ENSDART00000146098
Pim proto-oncogene, serine/threonine kinase, related 49
chr3_-_29977495 2.44 ENSDART00000077111
hydroxysteroid (17-beta) dehydrogenase 14
chr18_-_40773413 2.44 ENSDART00000133797
vasodilator stimulated phosphoprotein b
chr16_-_27566552 2.43 ENSDART00000142102
zgc:153215
chr11_-_11471857 2.39 ENSDART00000030103
keratin 94
chr3_+_3545825 2.39 ENSDART00000109060

chr8_+_28467893 2.38 ENSDART00000189724
solute carrier family 52 (riboflavin transporter), member 3
chr15_-_35410860 2.37 ENSDART00000191267
MDS1 and EVI1 complex locus
chr7_-_57332915 2.31 ENSDART00000162653

chr17_+_23994633 2.31 ENSDART00000156988
si:ch211-63b16.3
chr3_+_3099492 2.31 ENSDART00000154156
si:dkey-30g5.1
chr3_+_56645710 2.29 ENSDART00000193978

chr6_+_41039166 2.28 ENSDART00000125659
ectonucleoside triphosphate diphosphohydrolase 8
chr7_-_35126374 2.27 ENSDART00000141211
hydroxysteroid (11-beta) dehydrogenase 2
chr6_-_21091948 2.26 ENSDART00000057348
inhibin, alpha
chr2_-_36604589 2.23 ENSDART00000167352
T-cell receptor alpha/delta variable 41.0
chr9_+_22359919 2.22 ENSDART00000009591
crystallin, gamma S4
chr2_-_17115256 2.21 ENSDART00000190488
PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)
chr19_-_9786914 2.20 ENSDART00000181669
si:dkey-14o18.2
chr9_-_23891102 2.17 ENSDART00000186799
ankyrin repeat and SOCS box containing 18
chr17_+_48164536 2.15 ENSDART00000161750
ENSDART00000156923
pleckstrin homology domain containing, family D (with coiled-coil domains) member 1
chr9_-_18911608 2.14 ENSDART00000138785
si:dkey-239h2.3
chr8_+_17868506 2.12 ENSDART00000175436
solute carrier family 44, member 5b
chr8_+_2575993 2.12 ENSDART00000112914
si:ch211-51h9.7
chr20_-_42534153 2.09 ENSDART00000061122
regulatory factor X, 6
chr10_-_35149513 2.08 ENSDART00000063434
ENSDART00000131291
receptor-interacting serine-threonine kinase 4
chr2_-_32768951 2.06 ENSDART00000004712
beaded filament structural protein 2, phakinin
chr21_-_25741411 2.05 ENSDART00000101211
claudin h
chr18_-_22713621 2.04 ENSDART00000079013
si:ch73-113g13.2
chr4_+_65607540 2.03 ENSDART00000192218
si:dkey-205i10.2
chr2_+_19633493 2.02 ENSDART00000147989
Pim proto-oncogene, serine/threonine kinase, related 54
chr4_+_70414733 2.02 ENSDART00000162778
si:dkey-190j3.3
chr4_+_17280868 2.02 ENSDART00000145349
branched chain amino-acid transaminase 1, cytosolic
chr23_-_1348933 1.99 ENSDART00000168981

chr12_+_19030391 1.98 ENSDART00000153927
si:ch73-139e5.2
chr15_+_43398317 1.96 ENSDART00000182528
ENSDART00000172154
ENSDART00000187688
actinin, alpha 4
chr15_-_3736149 1.96 ENSDART00000182986
lysophosphatidic acid receptor 6a
chr24_-_26820698 1.96 ENSDART00000147788
fibronectin type III domain containing 3Bb
chr7_+_27317174 1.96 ENSDART00000193058
SRY (sex determining region Y)-box 6
chr5_+_26686639 1.94 ENSDART00000079064
transport and golgi organization 2 homolog (Drosophila)
chr5_+_40835601 1.94 ENSDART00000147767
si:dkey-3h3.3
chr25_-_27842654 1.93 ENSDART00000154852
ENSDART00000156906
ankyrin repeat and SOCS box containing 15a
chr4_-_43731342 1.93 ENSDART00000146627
si:ch211-226o13.3
chr4_+_25693463 1.93 ENSDART00000132864
acyl-CoA thioesterase 18
chr14_-_9713549 1.93 ENSDART00000193356
ENSDART00000166739
si:zfos-2326c3.2
chr13_+_46941930 1.93 ENSDART00000056962
F-box protein 5
chr19_-_17208728 1.93 ENSDART00000151228
stathmin 1a
chr5_-_30380593 1.91 ENSDART00000148039
sorting nexin 19a
chr18_+_33009828 1.90 ENSDART00000160100
olfactory receptor C family, j1
chr1_-_59102320 1.90 ENSDART00000193379
si:zfos-2330d3.7
chr5_-_20205075 1.90 ENSDART00000051611
D-amino-acid oxidase, tandem duplicate 3
chr17_+_45305645 1.88 ENSDART00000172488
calpain 3a, (p94)
chr11_+_20896122 1.87 ENSDART00000162339
ENSDART00000181111

chr6_+_52891947 1.85 ENSDART00000174159

chr2_-_19576640 1.85 ENSDART00000141021
Pim proto-oncogene, serine/threonine kinase, related 51
chr14_+_46313396 1.84 ENSDART00000047525
crystallin, beta A1, like 1
chr7_+_10562118 1.83 ENSDART00000185188
ENSDART00000168801
zinc finger, AN1-type domain 6
chr21_-_2415808 1.82 ENSDART00000171179
si:ch211-241b2.5
chr19_-_18152407 1.81 ENSDART00000193264
ENSDART00000016135
nuclear factor, erythroid 2-like 3
chr17_-_53440103 1.81 ENSDART00000156719
ENSDART00000156396
c-myc binding protein
chr7_+_30240791 1.81 ENSDART00000109243
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Bb
chr5_+_57658898 1.80 ENSDART00000074268
ENSDART00000124568
zgc:153929
chr6_-_6254432 1.77 ENSDART00000081952
reticulon 4a
chr7_+_26058772 1.75 ENSDART00000101123
ENSDART00000173893
si:dkey-6n21.13
chr5_-_54197084 1.75 ENSDART00000163640
G protein-coupled receptor kinase 1 b
chr20_+_31217495 1.71 ENSDART00000020252
protein disulfide isomerase family A, member 6
chr23_-_29357764 1.71 ENSDART00000156512
si:ch211-129o18.4
chr9_-_12811936 1.70 ENSDART00000188490
myosin X-like 3
chr3_+_46764022 1.69 ENSDART00000023814
protein kinase C substrate 80K-H
chr3_-_53114299 1.68 ENSDART00000109390

chr19_-_19721556 1.68 ENSDART00000165196
even-skipped homeobox 1
chr7_-_24181159 1.68 ENSDART00000181206
zgc:153151
chr1_+_44173245 1.68 ENSDART00000159450
ENSDART00000106048
ENSDART00000157763
catenin (cadherin-associated protein), delta 1
chr7_+_48555626 1.67 ENSDART00000125483
ENSDART00000083514
potassium voltage-gated channel, KQT-like subfamily, member 1
chr3_-_29891218 1.67 ENSDART00000142118
solute carrier family 25, member 39
chr5_+_69868911 1.67 ENSDART00000014649
ENSDART00000188215
ENSDART00000167385
UDP glucuronosyltransferase 2 family, polypeptide A5
chr21_-_40348790 1.66 ENSDART00000178123

chr21_-_41065369 1.66 ENSDART00000143749
leucyl-tRNA synthetase b
chr14_-_8787525 1.66 ENSDART00000160848
transforming growth factor, beta 2, like
chr17_-_23609210 1.65 ENSDART00000064003
interferon-induced protein with tetratricopeptide repeats 15
chr7_+_22585447 1.65 ENSDART00000149144
cholinergic receptor, nicotinic, beta 1 (muscle) like

Network of associatons between targets according to the STRING database.

First level regulatory network of sox10

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 13.7 GO:0010872 regulation of cholesterol esterification(GO:0010872) positive regulation of cholesterol esterification(GO:0010873)
2.4 7.2 GO:0009120 deoxyribonucleoside metabolic process(GO:0009120) thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
2.1 10.6 GO:0046952 ketone body catabolic process(GO:0046952)
1.2 6.0 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863) protein localization to endoplasmic reticulum exit site(GO:0070973)
1.0 4.9 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
1.0 7.7 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.9 5.6 GO:0034334 adherens junction maintenance(GO:0034334) mesendoderm migration(GO:0090133) cell migration involved in mesendoderm migration(GO:0090134)
0.9 2.7 GO:1902176 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175) negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902176)
0.8 2.4 GO:0072196 proximal/distal pattern formation involved in nephron development(GO:0072047) proximal/distal pattern formation involved in pronephric nephron development(GO:0072196)
0.8 8.7 GO:0006032 chitin catabolic process(GO:0006032)
0.7 3.6 GO:0046485 ether lipid metabolic process(GO:0046485)
0.7 4.2 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.7 3.5 GO:0071938 vitamin A transport(GO:0071938) vitamin A import(GO:0071939)
0.7 2.1 GO:0061178 insulin secretion involved in cellular response to glucose stimulus(GO:0035773) regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.7 6.5 GO:0015746 tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
0.6 4.1 GO:0002931 response to ischemia(GO:0002931)
0.5 3.1 GO:0017187 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.5 2.0 GO:0009098 leucine biosynthetic process(GO:0009098)
0.5 1.5 GO:0018872 arsonoacetate metabolic process(GO:0018872)
0.5 1.9 GO:0051352 negative regulation of ligase activity(GO:0051352) negative regulation of ubiquitin-protein transferase activity(GO:0051444) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.5 1.9 GO:0009078 alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080) D-alanine family amino acid metabolic process(GO:0046144) D-alanine metabolic process(GO:0046436) D-alanine catabolic process(GO:0055130)
0.4 2.4 GO:0032218 riboflavin transport(GO:0032218)
0.4 3.5 GO:2001240 histone dephosphorylation(GO:0016576) negative regulation of signal transduction in absence of ligand(GO:1901099) regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001239) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.4 1.1 GO:2000638 response to sterol(GO:0036314) cellular response to sterol(GO:0036315) SREBP-SCAP complex retention in endoplasmic reticulum(GO:0036316) regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.4 1.8 GO:0060231 mesenchymal to epithelial transition(GO:0060231)
0.4 11.3 GO:0060030 dorsal convergence(GO:0060030)
0.4 1.4 GO:0030149 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.3 17.1 GO:0042737 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.3 2.3 GO:0034650 cortisol metabolic process(GO:0034650)
0.3 6.1 GO:0006743 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone metabolic process(GO:1901661) quinone biosynthetic process(GO:1901663)
0.3 1.5 GO:0035678 neuromast hair cell morphogenesis(GO:0035678)
0.3 9.3 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.3 2.9 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.3 2.9 GO:0072498 embryonic skeletal joint development(GO:0072498)
0.3 1.4 GO:1902514 calcium ion transmembrane transport via high voltage-gated calcium channel(GO:0061577) regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.3 1.7 GO:0003151 outflow tract morphogenesis(GO:0003151)
0.3 3.9 GO:0030311 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.3 1.4 GO:0014707 branchiomeric skeletal muscle development(GO:0014707)
0.3 1.6 GO:1902946 positive regulation of receptor-mediated endocytosis(GO:0048260) protein localization to early endosome(GO:1902946)
0.3 1.4 GO:0009794 regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.3 2.9 GO:0036368 cone photoresponse recovery(GO:0036368)
0.3 5.4 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.3 1.6 GO:0071405 response to methanol(GO:0033986) cellular response to methanol(GO:0071405)
0.2 2.7 GO:0000710 meiotic mismatch repair(GO:0000710)
0.2 20.8 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.2 0.9 GO:0003261 cardiac muscle progenitor cell migration to the midline involved in heart field formation(GO:0003261)
0.2 0.9 GO:0070285 pigment cell development(GO:0070285)
0.2 2.5 GO:2000403 positive regulation of lymphocyte migration(GO:2000403) positive regulation of T cell migration(GO:2000406)
0.2 1.0 GO:0006154 adenosine catabolic process(GO:0006154) inosine metabolic process(GO:0046102) inosine biosynthetic process(GO:0046103)
0.2 0.8 GO:0003322 pancreatic A cell development(GO:0003322)
0.2 3.2 GO:0008078 mesodermal cell migration(GO:0008078)
0.2 0.8 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.2 2.0 GO:0060612 adipose tissue development(GO:0060612)
0.2 1.5 GO:0006833 water transport(GO:0006833)
0.2 2.3 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.2 1.1 GO:0010799 regulation of peptidyl-threonine phosphorylation(GO:0010799) negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.2 2.2 GO:0000002 mitochondrial genome maintenance(GO:0000002)
0.2 5.3 GO:0002068 glandular epithelial cell development(GO:0002068) type B pancreatic cell development(GO:0003323)
0.2 2.5 GO:0014812 muscle cell migration(GO:0014812)
0.2 0.5 GO:0008344 adult locomotory behavior(GO:0008344)
0.2 16.4 GO:0006956 complement activation(GO:0006956)
0.2 3.1 GO:0097178 ruffle assembly(GO:0097178)
0.1 1.0 GO:0098937 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.1 4.6 GO:0009395 phospholipid catabolic process(GO:0009395)
0.1 1.5 GO:0032048 cardiolipin metabolic process(GO:0032048) positive regulation of heart contraction(GO:0045823) phosphatidylglycerol metabolic process(GO:0046471)
0.1 1.8 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.1 0.6 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.1 1.4 GO:0098719 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 6.1 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.1 1.2 GO:0042664 negative regulation of endodermal cell fate specification(GO:0042664)
0.1 4.8 GO:0071219 cellular response to molecule of bacterial origin(GO:0071219) cellular response to lipopolysaccharide(GO:0071222)
0.1 3.0 GO:0009214 cyclic nucleotide catabolic process(GO:0009214)
0.1 0.8 GO:0071233 response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031)
0.1 5.5 GO:0007131 reciprocal meiotic recombination(GO:0007131)
0.1 1.2 GO:0099638 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887) endosome to plasma membrane protein transport(GO:0099638) neurotransmitter receptor transport, endosome to plasma membrane(GO:0099639)
0.1 3.8 GO:0015908 fatty acid transport(GO:0015908)
0.1 12.9 GO:0002088 lens development in camera-type eye(GO:0002088)
0.1 1.2 GO:0051121 lipoxygenase pathway(GO:0019372) linoleic acid metabolic process(GO:0043651) hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.1 1.2 GO:0030431 sleep(GO:0030431)
0.1 2.4 GO:0001843 neural tube closure(GO:0001843)
0.1 1.1 GO:0060753 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.1 1.5 GO:0009409 response to cold(GO:0009409)
0.1 0.4 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.1 1.5 GO:0030259 lipid glycosylation(GO:0030259)
0.1 1.5 GO:0016584 nucleosome positioning(GO:0016584)
0.1 3.9 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.1 1.3 GO:0046549 retinal cone cell development(GO:0046549)
0.1 8.4 GO:0008285 negative regulation of cell proliferation(GO:0008285)
0.1 1.1 GO:0002084 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.1 0.6 GO:0050819 negative regulation of coagulation(GO:0050819)
0.1 1.8 GO:0072662 protein targeting to peroxisome(GO:0006625) peroxisomal transport(GO:0043574) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.1 0.5 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.1 1.4 GO:0098754 detoxification(GO:0098754)
0.1 1.3 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1 1.5 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.1 1.2 GO:0019433 triglyceride catabolic process(GO:0019433)
0.1 3.3 GO:0045104 intermediate filament-based process(GO:0045103) intermediate filament cytoskeleton organization(GO:0045104)
0.1 1.1 GO:0048769 sarcomerogenesis(GO:0048769)
0.1 4.3 GO:0060048 cardiac muscle contraction(GO:0060048)
0.1 1.5 GO:0006491 N-glycan processing(GO:0006491)
0.1 0.8 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.1 0.8 GO:0032098 regulation of appetite(GO:0032098)
0.1 6.3 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.1 1.5 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway(GO:2001243)
0.1 1.7 GO:0006783 heme biosynthetic process(GO:0006783)
0.1 0.6 GO:0018120 peptidyl-arginine ADP-ribosylation(GO:0018120)
0.1 0.8 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 2.0 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.3 GO:0035093 spermatid nucleus differentiation(GO:0007289) sperm chromatin condensation(GO:0035092) spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.0 6.9 GO:0007601 visual perception(GO:0007601)
0.0 2.6 GO:0001946 lymphangiogenesis(GO:0001946)
0.0 1.7 GO:0008589 regulation of smoothened signaling pathway(GO:0008589)
0.0 1.2 GO:0035987 endodermal cell differentiation(GO:0035987)
0.0 15.2 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 6.3 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.0 0.5 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.0 1.1 GO:0035148 tube formation(GO:0035148)
0.0 0.2 GO:0042311 vasodilation(GO:0042311)
0.0 0.1 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.0 2.7 GO:0006119 oxidative phosphorylation(GO:0006119)
0.0 0.3 GO:0050909 sensory perception of taste(GO:0050909)
0.0 1.1 GO:0006270 DNA replication initiation(GO:0006270)
0.0 3.2 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.7 GO:0040023 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.4 GO:1901642 nucleoside transport(GO:0015858) nucleoside transmembrane transport(GO:1901642)
0.0 1.5 GO:0007062 sister chromatid cohesion(GO:0007062)
0.0 2.1 GO:0006672 ceramide metabolic process(GO:0006672)
0.0 1.1 GO:0002548 monocyte chemotaxis(GO:0002548) cellular response to interferon-gamma(GO:0071346)
0.0 1.2 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 0.7 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 0.4 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 1.9 GO:0007030 Golgi organization(GO:0007030)
0.0 0.2 GO:1901224 positive regulation of NIK/NF-kappaB signaling(GO:1901224)
0.0 0.7 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.9 GO:0009247 glycolipid biosynthetic process(GO:0009247)
0.0 0.9 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 1.1 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.0 0.5 GO:0006278 RNA-dependent DNA biosynthetic process(GO:0006278) telomere maintenance via telomerase(GO:0007004)
0.0 0.6 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.7 GO:0003094 glomerular filtration(GO:0003094)
0.0 0.4 GO:0019229 regulation of vasoconstriction(GO:0019229)
0.0 0.7 GO:0015807 L-amino acid transport(GO:0015807)
0.0 1.0 GO:0031396 regulation of protein ubiquitination(GO:0031396)
0.0 0.4 GO:0006101 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101) tricarboxylic acid metabolic process(GO:0072350)
0.0 2.7 GO:0006954 inflammatory response(GO:0006954)
0.0 1.6 GO:0006821 chloride transport(GO:0006821)
0.0 1.1 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.6 GO:0099515 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 1.4 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.0 0.1 GO:0018410 C-terminal protein amino acid modification(GO:0018410)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 6.4 GO:0070062 extracellular exosome(GO:0070062)
1.1 13.7 GO:0042627 chylomicron(GO:0042627)
0.5 1.5 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.5 1.5 GO:0044316 cone cell pedicle(GO:0044316)
0.4 1.7 GO:0017177 glucosidase II complex(GO:0017177)
0.4 1.1 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.3 2.5 GO:0032783 ELL-EAF complex(GO:0032783)
0.3 5.6 GO:0030057 desmosome(GO:0030057)
0.3 4.1 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.2 6.0 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.2 1.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.2 0.8 GO:0097268 cytoophidium(GO:0097268)
0.2 9.3 GO:0008305 integrin complex(GO:0008305)
0.2 1.3 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.2 1.4 GO:0031526 brush border membrane(GO:0031526)
0.1 1.7 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 0.5 GO:0070209 ASTRA complex(GO:0070209)
0.1 5.9 GO:0031941 filamentous actin(GO:0031941)
0.1 1.5 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 1.2 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 5.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 0.8 GO:0061700 GATOR2 complex(GO:0061700)
0.1 10.2 GO:0005882 intermediate filament(GO:0005882)
0.1 5.2 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 0.8 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 10.3 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.1 3.1 GO:0016605 PML body(GO:0016605)
0.1 3.0 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.1 0.3 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 1.5 GO:0032420 stereocilium(GO:0032420)
0.1 1.5 GO:0008278 cohesin complex(GO:0008278)
0.0 0.4 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor heterodimeric complex(GO:0038039) G-protein coupled receptor complex(GO:0097648)
0.0 0.4 GO:0070652 HAUS complex(GO:0070652)
0.0 3.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 3.1 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.6 GO:0044545 NSL complex(GO:0044545)
0.0 0.7 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 3.7 GO:0000786 nucleosome(GO:0000786)
0.0 6.5 GO:0000785 chromatin(GO:0000785)
0.0 0.5 GO:0000813 ESCRT I complex(GO:0000813)
0.0 1.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 37.0 GO:0005615 extracellular space(GO:0005615)
0.0 9.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 1.4 GO:0005657 replication fork(GO:0005657)
0.0 1.4 GO:0005902 microvillus(GO:0005902)
0.0 2.7 GO:0000228 nuclear chromosome(GO:0000228)
0.0 0.5 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 4.8 GO:0070161 adherens junction(GO:0005912) anchoring junction(GO:0070161)
0.0 0.3 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.4 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 13.6 GO:0005576 extracellular region(GO:0005576)
0.0 0.4 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 1.9 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.0 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.0 GO:0005930 axoneme(GO:0005930)
0.0 9.1 GO:0005739 mitochondrion(GO:0005739)
0.0 0.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.5 GO:0031514 motile cilium(GO:0031514)
0.0 0.1 GO:1990071 TRAPPII protein complex(GO:1990071)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 15.4 GO:0030267 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
2.7 13.7 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
2.6 7.7 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
2.1 10.6 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
1.9 9.3 GO:0019960 C-X3-C chemokine binding(GO:0019960) protein binding involved in cell-matrix adhesion(GO:0098634) collagen binding involved in cell-matrix adhesion(GO:0098639)
1.6 6.5 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
1.4 7.2 GO:0002061 uracil binding(GO:0002058) pyrimidine nucleobase binding(GO:0002061) dihydropyrimidine dehydrogenase (NADP+) activity(GO:0017113)
1.3 5.4 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
1.2 7.1 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
1.0 3.0 GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113)
0.9 5.5 GO:0015616 DNA translocase activity(GO:0015616)
0.8 7.4 GO:0048039 ubiquinone binding(GO:0048039)
0.8 8.7 GO:0004568 chitinase activity(GO:0004568)
0.8 3.1 GO:0008488 gamma-glutamyl carboxylase activity(GO:0008488)
0.5 4.2 GO:0015154 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.5 2.0 GO:0052655 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.5 3.4 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.5 1.5 GO:0030792 arsenite methyltransferase activity(GO:0030791) methylarsonite methyltransferase activity(GO:0030792)
0.5 1.4 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.5 1.9 GO:0003884 D-amino-acid oxidase activity(GO:0003884)
0.4 2.2 GO:0043139 5'-3' DNA helicase activity(GO:0043139)
0.4 5.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.4 3.0 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.4 1.3 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.4 2.5 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.4 3.6 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.4 2.4 GO:0032217 riboflavin transporter activity(GO:0032217)
0.4 1.4 GO:0008117 sphinganine-1-phosphate aldolase activity(GO:0008117)
0.3 1.7 GO:0050254 rhodopsin kinase activity(GO:0050254)
0.3 3.5 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.3 2.7 GO:0003834 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.3 1.5 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.3 5.9 GO:0051393 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.3 2.6 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.3 3.9 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.3 1.7 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.3 1.3 GO:0004385 guanylate kinase activity(GO:0004385)
0.3 6.3 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.3 17.1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.3 1.3 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.2 2.4 GO:0005522 profilin binding(GO:0005522)
0.2 2.2 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.2 4.1 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.2 0.9 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017) platelet-derived growth factor binding(GO:0048407)
0.2 1.4 GO:0048156 tau protein binding(GO:0048156)
0.2 3.8 GO:0045134 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.2 5.9 GO:0051787 misfolded protein binding(GO:0051787)
0.2 0.8 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.2 0.8 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558)
0.2 3.8 GO:0033691 sialic acid binding(GO:0033691)
0.2 1.7 GO:0016530 metallochaperone activity(GO:0016530)
0.2 2.9 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.2 3.2 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.2 1.4 GO:0034632 retinol transporter activity(GO:0034632)
0.2 0.8 GO:0003883 CTP synthase activity(GO:0003883)
0.2 1.0 GO:0070573 metallodipeptidase activity(GO:0070573)
0.2 1.1 GO:0008142 oxysterol binding(GO:0008142)
0.2 0.7 GO:0071889 14-3-3 protein binding(GO:0071889)
0.2 1.2 GO:0004051 arachidonate 5-lipoxygenase activity(GO:0004051)
0.2 20.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 1.5 GO:0015250 water channel activity(GO:0015250)
0.2 12.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.2 4.4 GO:0008378 galactosyltransferase activity(GO:0008378)
0.2 8.8 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 2.7 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 0.4 GO:0003994 aconitate hydratase activity(GO:0003994)
0.1 3.2 GO:0004065 arylsulfatase activity(GO:0004065)
0.1 2.0 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 1.7 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 0.5 GO:0046556 alpha-L-arabinofuranosidase activity(GO:0046556)
0.1 1.0 GO:0043394 glycoprotein binding(GO:0001948) proteoglycan binding(GO:0043394)
0.1 1.4 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.1 1.2 GO:0070700 BMP receptor binding(GO:0070700)
0.1 0.8 GO:0070728 leucine binding(GO:0070728)
0.1 1.2 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.1 7.5 GO:0003823 antigen binding(GO:0003823)
0.1 6.0 GO:0019209 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.1 0.4 GO:0001596 angiotensin type I receptor activity(GO:0001596) angiotensin type II receptor activity(GO:0004945)
0.1 6.5 GO:0009055 electron carrier activity(GO:0009055)
0.1 2.3 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0033764)
0.1 1.1 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 0.9 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.1 1.1 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.1 1.3 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 0.5 GO:0060182 apelin receptor activity(GO:0060182)
0.1 1.1 GO:0004623 phospholipase A2 activity(GO:0004623)
0.1 1.5 GO:0004622 lysophospholipase activity(GO:0004622)
0.1 3.2 GO:0042923 neuropeptide binding(GO:0042923)
0.1 0.8 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.1 0.9 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 0.2 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.1 1.5 GO:0004875 complement receptor activity(GO:0004875)
0.1 1.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 1.1 GO:0031729 CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729)
0.1 0.8 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.1 1.6 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.1 2.6 GO:0005109 frizzled binding(GO:0005109)
0.1 1.1 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 1.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 0.3 GO:0030548 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.1 4.0 GO:0001594 trace-amine receptor activity(GO:0001594)
0.1 1.4 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 0.5 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.1 0.6 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.1 11.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.4 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.1 GO:0055105 ubiquitin-protein transferase inhibitor activity(GO:0055105)
0.0 1.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 3.9 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 5.6 GO:0005125 cytokine activity(GO:0005125)
0.0 4.1 GO:0045296 cadherin binding(GO:0045296)
0.0 1.1 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 21.2 GO:0005198 structural molecule activity(GO:0005198)
0.0 1.2 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.8 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 1.1 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.5 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.4 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 1.2 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.3 GO:0016504 peptidase activator activity(GO:0016504)
0.0 4.7 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.4 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828)
0.0 1.2 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 0.4 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 1.2 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.5 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.2 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.0 0.5 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 1.2 GO:0004620 phospholipase activity(GO:0004620)
0.0 1.0 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 1.5 GO:0003678 DNA helicase activity(GO:0003678)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 11.0 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 1.3 GO:0003724 RNA helicase activity(GO:0003724)
0.0 1.6 GO:0005254 chloride channel activity(GO:0005254)
0.0 0.7 GO:0005507 copper ion binding(GO:0005507)
0.0 0.3 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 1.4 GO:0019955 cytokine binding(GO:0019955)
0.0 1.1 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 0.1 GO:0051998 carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
0.0 0.1 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.0 0.6 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.2 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 1.7 GO:0003774 motor activity(GO:0003774)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 8.8 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.2 1.4 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.2 1.4 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 20.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 5.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 1.4 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 3.9 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 1.3 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 0.4 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.1 1.9 PID PLK1 PATHWAY PLK1 signaling events
0.1 5.5 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 2.5 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.9 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.7 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 2.2 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.5 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.7 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 2.0 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 0.2 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.3 PID EPO PATHWAY EPO signaling pathway
0.0 1.2 PID NOTCH PATHWAY Notch signaling pathway
0.0 1.4 PID CMYB PATHWAY C-MYB transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.6 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
1.7 20.8 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.6 7.7 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.5 3.1 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.4 3.1 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.3 1.3 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.3 2.6 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.3 2.3 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.3 5.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.2 2.6 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.2 1.7 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.2 5.3 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.2 3.2 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.2 3.8 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 2.7 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 1.1 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 1.6 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 2.0 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 5.6 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 4.0 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 1.9 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 3.9 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 1.4 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 3.2 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 1.5 REACTOME MEIOSIS Genes involved in Meiosis
0.1 1.4 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 1.7 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 4.3 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 0.9 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.3 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.2 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 1.5 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.5 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 0.9 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction