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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for sox1a+sox1b

Z-value: 0.28

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Transcription factors associated with sox1a+sox1b

Gene Symbol Gene ID Gene Info
sox1b
ENSDARG00000008131 SRY-box transcription factor 1b
sox1a
ENSDARG00000069866 SRY-box transcription factor 1a
sox1a
ENSDARG00000110682 SRY-box transcription factor 1a
sox1a
ENSDARG00000114571 SRY-box transcription factor 1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
sox1bdr11_v1_chr1_+_46194333_461943330.356.5e-04Click!
sox1adr11_v1_chr9_+_21722733_217227330.303.8e-03Click!

Activity profile of sox1a+sox1b motif

Sorted Z-values of sox1a+sox1b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_41472228 2.04 ENSDART00000113388
dlx5a
distal-less homeobox 5a
chr14_+_9421510 1.70 ENSDART00000123652
hmgn6
high mobility group nucleosome binding domain 6
chr2_+_1881334 1.58 ENSDART00000161420
adgrl2b.1
adhesion G protein-coupled receptor L2b, tandem duplicate 1
chr14_+_45883687 1.06 ENSDART00000114790
flrt1b
fibronectin leucine rich transmembrane protein 1b
chr8_-_436137 0.97 ENSDART00000187021
CABZ01063543.1

chr16_-_21047872 0.97 ENSDART00000131582
cbx3b
chromobox homolog 3b
chr23_+_17800717 0.89 ENSDART00000122654
ENSDART00000044986
rnd1a
Rho family GTPase 1a
chr12_+_26512569 0.88 ENSDART00000066264
chad
chondroadherin
chr11_-_45434959 0.78 ENSDART00000173106
ENSDART00000172767
ENSDART00000172933
ENSDART00000172986
rfc4
replication factor C (activator 1) 4
chr17_-_37054959 0.75 ENSDART00000151921
dnmt3ab
DNA (cytosine-5-)-methyltransferase 3 alpha b
chr23_+_31815423 0.66 ENSDART00000075730
ENSDART00000075726
myb
v-myb avian myeloblastosis viral oncogene homolog
chr14_+_20342553 0.65 ENSDART00000074070
ENSDART00000167637
aff2
AF4/FMR2 family, member 2
chr22_+_35131890 0.64 ENSDART00000003303
ENSDART00000130581
rnf13
ring finger protein 13
chr2_+_48687528 0.63 ENSDART00000158312
si:dkey-53k12.1
si:dkey-53k12.1
chr5_-_30079434 0.62 ENSDART00000133981
bco2a
beta-carotene oxygenase 2a
chr16_-_8927425 0.62 ENSDART00000000382
triob
trio Rho guanine nucleotide exchange factor b
chr19_+_9533008 0.58 ENSDART00000104607
fam131ba
family with sequence similarity 131, member Ba
chr24_-_9291857 0.52 ENSDART00000149875
tgif1
TGFB-induced factor homeobox 1
chr2_+_7715810 0.48 ENSDART00000130781
eif4a2
eukaryotic translation initiation factor 4A, isoform 2
chr19_+_23301050 0.45 ENSDART00000193713
si:dkey-79i2.4
si:dkey-79i2.4
chr20_-_40370736 0.43 ENSDART00000041229
fabp7b
fatty acid binding protein 7, brain, b
chr18_-_41754020 0.42 ENSDART00000077898
grk7b
G protein-coupled receptor kinase 7b
chr7_+_61480296 0.42 ENSDART00000083255
adam19a
ADAM metallopeptidase domain 19a
chr9_-_6624663 0.42 ENSDART00000092537
GPR45
si:dkeyp-118h3.5
chr8_+_28065803 0.41 ENSDART00000178481
kcnd3
potassium voltage-gated channel, Shal-related subfamily, member 3
chr16_-_21047483 0.39 ENSDART00000136235
cbx3b
chromobox homolog 3b
chr12_+_30168342 0.38 ENSDART00000142756
ablim1b
actin binding LIM protein 1b
chr23_-_12158685 0.38 ENSDART00000135035
fam217b
family with sequence similarity 217, member B
chr11_+_37612214 0.37 ENSDART00000172899
ENSDART00000077496
hp1bp3
heterochromatin protein 1, binding protein 3
chr6_-_22146258 0.37 ENSDART00000181700
gga1
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
chr4_+_29206813 0.37 ENSDART00000131893
si:dkey-23a23.1
si:dkey-23a23.1
chr22_+_10010292 0.36 ENSDART00000180096
BX324216.4

chr7_+_50796422 0.36 ENSDART00000123868
dthd1
death domain containing 1
chr23_+_6926183 0.33 ENSDART00000149882
si:ch211-117c9.1
si:ch211-117c9.1
chr9_-_27649406 0.33 ENSDART00000181270
ENSDART00000187112
stxbp5l
syntaxin binding protein 5-like
chrM_+_6425 0.32 ENSDART00000093606
mt-co1
cytochrome c oxidase I, mitochondrial
chr11_+_33284837 0.32 ENSDART00000166239
ENSDART00000111412
nkpd1
NTPase, KAP family P-loop domain containing 1
chr10_-_34889053 0.32 ENSDART00000136966
ccdc169
coiled-coil domain containing 169
chr14_+_6429399 0.31 ENSDART00000149783
ENSDART00000148461
abca1b
ATP-binding cassette, sub-family A (ABC1), member 1B
chr19_+_20177887 0.30 ENSDART00000008595
tra2a
transformer 2 alpha homolog
chr20_+_27093042 0.30 ENSDART00000024595
ubr7
ubiquitin protein ligase E3 component n-recognin 7
chr19_+_11978209 0.30 ENSDART00000111568
polr2k
polymerase (RNA) II (DNA directed) polypeptide K
chr1_+_50639416 0.30 ENSDART00000141977
herc3
HECT and RLD domain containing E3 ubiquitin protein ligase 3
chr16_-_44878245 0.30 ENSDART00000154391
ENSDART00000154925
ENSDART00000154697
arhgap33
Rho GTPase activating protein 33
chr7_-_47148440 0.29 ENSDART00000185435
ENSDART00000189719
BX005073.3

chr22_+_9994833 0.29 ENSDART00000172696
ENSDART00000192101
BX324216.1

chr11_+_37612672 0.28 ENSDART00000157993
hp1bp3
heterochromatin protein 1, binding protein 3
chr5_-_47727819 0.28 ENSDART00000165249
cox7c
cytochrome c oxidase, subunit VIIc
chr11_+_31324335 0.26 ENSDART00000088093
sipa1l2
signal-induced proliferation-associated 1 like 2
chr21_+_37355716 0.26 ENSDART00000131188
nsd1b
nuclear receptor binding SET domain protein 1b
chr23_-_24247672 0.26 ENSDART00000141552
zbtb17
zinc finger and BTB domain containing 17
chr7_+_57677120 0.21 ENSDART00000110623
arsj
arylsulfatase family, member J
chr7_-_18877109 0.21 ENSDART00000113593
mllt3
MLLT3, super elongation complex subunit
chr6_-_37513133 0.18 ENSDART00000147826
jade3
jade family PHD finger 3
chr14_-_9420911 0.18 ENSDART00000081158
sh3bgrl
SH3 domain binding glutamate-rich protein like
chr16_-_30826712 0.18 ENSDART00000122474
ptk2ab
protein tyrosine kinase 2ab
chr8_+_49096486 0.17 ENSDART00000192998
zgc:56525
zgc:56525
chr5_+_30520249 0.16 ENSDART00000013431
hmbsa
hydroxymethylbilane synthase a
chr4_-_9664995 0.15 ENSDART00000180105
ENSDART00000029084
dmtf1
cyclin D binding myb-like transcription factor 1
chr13_-_48764180 0.14 ENSDART00000167157
si:ch1073-266p11.2
si:ch1073-266p11.2
chr5_+_51833132 0.14 ENSDART00000167491
papd4
PAP associated domain containing 4
chr18_-_45761868 0.14 ENSDART00000025423
cstf3
cleavage stimulation factor, 3' pre-RNA, subunit 3
chr2_-_54039293 0.13 ENSDART00000166013
abhd8a
abhydrolase domain containing 8a
chr19_-_11977783 0.13 ENSDART00000183337
si:ch1073-296d18.1
si:ch1073-296d18.1
chr7_+_28960518 0.13 ENSDART00000182903
ENSDART00000188250
ENSDART00000191830
dok4
docking protein 4
chr24_+_35881984 0.12 ENSDART00000066587
klhl14
kelch-like family member 14
chr20_+_37300296 0.11 ENSDART00000180789
vta1
vesicle (multivesicular body) trafficking 1
chr4_-_9665267 0.10 ENSDART00000150318
dmtf1
cyclin D binding myb-like transcription factor 1
chr7_-_6553460 0.10 ENSDART00000172903
si:ch1073-220m6.1
si:ch1073-220m6.1
chr25_+_18475032 0.10 ENSDART00000073564
tes
testis derived transcript (3 LIM domains)
chr1_+_25732715 0.07 ENSDART00000140172
npy2r
neuropeptide Y receptor Y2
chr1_+_59328030 0.06 ENSDART00000172464
CABZ01052576.1

chr25_+_418932 0.06 ENSDART00000059193
prtgb
protogenin homolog b (Gallus gallus)
chr18_-_4958883 0.06 ENSDART00000143614
zbbx
zinc finger, B-box domain containing
chr20_-_23852174 0.05 ENSDART00000122414
si:dkey-15j16.6
si:dkey-15j16.6
chr15_-_951118 0.05 ENSDART00000171427
alox5b.1
arachidonate 5-lipoxygenase b, tandem duplicate 1
chr24_+_21092156 0.01 ENSDART00000028542
ccdc191
coiled-coil domain containing 191
chr14_-_17072736 0.01 ENSDART00000106333
phox2bb
paired-like homeobox 2bb

Network of associatons between targets according to the STRING database.

First level regulatory network of sox1a+sox1b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.0 GO:0021628 olfactory nerve development(GO:0021553) olfactory nerve morphogenesis(GO:0021627) olfactory nerve formation(GO:0021628)
0.1 0.4 GO:0097623 potassium ion export(GO:0071435) potassium ion export across plasma membrane(GO:0097623)
0.1 0.7 GO:0030852 regulation of granulocyte differentiation(GO:0030852) regulation of neutrophil differentiation(GO:0045658)
0.1 0.3 GO:0015990 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) electron transport coupled proton transport(GO:0015990)
0.1 0.6 GO:0046247 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.1 0.5 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.6 GO:0070828 heterochromatin organization(GO:0070828)
0.0 0.3 GO:0033700 phospholipid efflux(GO:0033700)
0.0 0.2 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
0.0 0.8 GO:0006305 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 0.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.2 GO:0043982 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.0 0.3 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.4 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.2 GO:0070309 lens fiber cell development(GO:0070307) lens fiber cell morphogenesis(GO:0070309)
0.0 0.3 GO:2000404 regulation of T cell migration(GO:2000404)
0.0 0.1 GO:0051256 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231) mitotic spindle midzone assembly(GO:0051256)
0.0 0.9 GO:0050919 negative chemotaxis(GO:0050919)
0.0 0.1 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0005663 DNA replication factor C complex(GO:0005663)
0.1 0.6 GO:0032783 ELL-EAF complex(GO:0032783)
0.0 0.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.1 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 3.3 GO:0000785 chromatin(GO:0000785)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.1 0.4 GO:0050254 rhodopsin kinase activity(GO:0050254)
0.1 1.7 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 0.8 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 0.6 GO:0003834 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.1 0.4 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 0.3 GO:0090554 phospholipid-translocating ATPase activity(GO:0004012) phosphatidylcholine-translocating ATPase activity(GO:0090554) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.1 0.8 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 0.9 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.4 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.2 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
0.0 0.6 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.6 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.3 GO:0045159 myosin II binding(GO:0045159)
0.0 0.3 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.3 GO:0034062 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 0.1 GO:1990404 protein ADP-ribosylase activity(GO:1990404)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.7 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.8 PID ATR PATHWAY ATR signaling pathway
0.0 0.2 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.0 0.5 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.5 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.3 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.2 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.4 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels