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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for sox7

Z-value: 0.73

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Transcription factors associated with sox7

Gene Symbol Gene ID Gene Info
sox7
ENSDARG00000030125 SRY-box transcription factor 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
sox7dr11_v1_chr20_+_19066858_190668580.631.2e-11Click!

Activity profile of sox7 motif

Sorted Z-values of sox7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr22_-_29204960 19.46 ENSDART00000131386
pvalb7
parvalbumin 7
chr22_-_29191152 19.24 ENSDART00000132702
pvalb7
parvalbumin 7
chr22_-_29205327 12.68 ENSDART00000183161
ENSDART00000189515
pvalb7
parvalbumin 7
chr15_-_23647078 9.75 ENSDART00000059366
ckmb
creatine kinase, muscle b
chr25_-_22639133 6.77 ENSDART00000073583
islr2
immunoglobulin superfamily containing leucine-rich repeat 2
chr2_-_24996441 5.99 ENSDART00000144795
slc35g2a
solute carrier family 35, member G2a
chr17_+_15534815 5.74 ENSDART00000159426
marcksb
myristoylated alanine-rich protein kinase C substrate b
chr20_-_25709247 5.46 ENSDART00000146711
si:dkeyp-117h8.2
si:dkeyp-117h8.2
chr16_+_46111849 5.43 ENSDART00000172232
sv2a
synaptic vesicle glycoprotein 2A
chr20_+_50956369 5.23 ENSDART00000170854
gphnb
gephyrin b
chr16_+_10777116 4.48 ENSDART00000190902
atp1a3b
ATPase Na+/K+ transporting subunit alpha 3b
chr14_+_6546516 4.01 ENSDART00000097214
adam19b
ADAM metallopeptidase domain 19b
chr9_-_23033818 3.87 ENSDART00000022392
rnd3b
Rho family GTPase 3b
chr22_-_12862415 3.86 ENSDART00000145156
ENSDART00000137280
glsa
glutaminase a
chr19_-_11031145 3.70 ENSDART00000151375
ENSDART00000027598
ENSDART00000137865
ENSDART00000188025
tpm3
tropomyosin 3
chr8_+_23174137 3.19 ENSDART00000189470
dnajc5aa
DnaJ (Hsp40) homolog, subfamily C, member 5aa
chr9_+_38369872 3.18 ENSDART00000193914
plcd4b
phospholipase C, delta 4b
chr5_+_34982318 2.98 ENSDART00000160504
ankra2
ankyrin repeat, family A (RFXANK-like), 2
chr21_-_18932761 2.77 ENSDART00000140129
med15
mediator complex subunit 15
chr14_-_6365223 2.74 ENSDART00000167446
slc44a1b
solute carrier family 44 (choline transporter), member 1b
chr11_-_35970966 2.65 ENSDART00000188805
itpr1b
inositol 1,4,5-trisphosphate receptor, type 1b
chr25_-_7999756 2.60 ENSDART00000159908
camk1db
calcium/calmodulin-dependent protein kinase 1Db
chr4_+_47178124 2.24 ENSDART00000170816
si:dkey-26m3.2
si:dkey-26m3.2
chr22_-_26558166 2.24 ENSDART00000111125
glis2a
GLIS family zinc finger 2a
chr5_-_69923241 2.22 ENSDART00000187389
fktn
fukutin
chr1_-_10669436 2.14 ENSDART00000152421
si:dkey-31e10.5
si:dkey-31e10.5
chr18_-_39200557 2.07 ENSDART00000132367
ENSDART00000183672
si:ch211-235f12.2
mapk6
si:ch211-235f12.2
mitogen-activated protein kinase 6
chr24_-_20652473 1.99 ENSDART00000179984
nktr
natural killer cell triggering receptor
chr1_-_470812 1.97 ENSDART00000192527
zgc:92518
zgc:92518
chr19_-_42462491 1.96 ENSDART00000131715
psmb4
proteasome subunit beta 4
chr8_+_2787042 1.88 ENSDART00000155275
sh3glb2a
SH3-domain GRB2-like endophilin B2a
chr21_-_41147818 1.87 ENSDART00000167339
ENSDART00000192730
msx2b
muscle segment homeobox 2b
chr11_+_44356707 1.78 ENSDART00000165219
srsf7b
serine/arginine-rich splicing factor 7b
chr2_-_27385934 1.74 ENSDART00000139886
toe1
target of EGR1, exonuclease
chr16_-_31933740 1.73 ENSDART00000125411
si:ch1073-90m23.1
si:ch1073-90m23.1
chr12_-_4540564 1.72 ENSDART00000106566
CABZ01030107.1

chr14_-_30490465 1.71 ENSDART00000173107
micu3b
mitochondrial calcium uptake family, member 3b
chr15_-_35252522 1.68 ENSDART00000144153
ENSDART00000059195
mff
mitochondrial fission factor
chr17_-_22010668 1.63 ENSDART00000031998
slc22a7b.1
solute carrier family 22 (organic anion transporter), member 7b, tandem duplicate 1
chr8_+_16726386 1.59 ENSDART00000144621
smim15
small integral membrane protein 15
chr8_+_35664152 1.56 ENSDART00000144520
si:dkeyp-14d3.1
si:dkeyp-14d3.1
chr19_+_10860485 1.55 ENSDART00000169962
si:ch73-347e22.4
si:ch73-347e22.4
chr13_+_24829996 1.40 ENSDART00000147194
si:ch211-223p8.8
si:ch211-223p8.8
chr8_-_46457233 1.36 ENSDART00000113214
sult1st7
sulfotransferase family 1, cytosolic sulfotransferase 7
chr22_-_16658996 1.35 ENSDART00000138429
si:dkey-38n4.2
si:dkey-38n4.2
chr16_+_27345383 1.34 ENSDART00000078250
ENSDART00000162857
nr4a3
nuclear receptor subfamily 4, group A, member 3
chr13_+_10799380 1.26 ENSDART00000126427
lrpprc
leucine-rich pentatricopeptide repeat containing
chr20_-_4766645 1.25 ENSDART00000147071
ENSDART00000152398
ak7a
adenylate kinase 7a
chr21_+_19330774 1.20 ENSDART00000109412
helq
helicase, POLQ like
chr21_+_31811202 1.14 ENSDART00000189846
si:ch211-12m10.1
si:ch211-12m10.1
chr8_-_40205712 1.06 ENSDART00000158927
anapc5
anaphase promoting complex subunit 5
chr8_-_22514918 1.01 ENSDART00000021514
ENSDART00000189272
apex2
APEX nuclease (apurinic/apyrimidinic endonuclease) 2
chr11_+_10541258 1.01 ENSDART00000132365
b3gnt5a
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5a
chr18_+_302796 1.00 ENSDART00000157434
ENSDART00000160279
lsm14ab
LSM14A mRNA processing body assembly factor b
chr10_-_23379146 0.89 ENSDART00000056369
cadm2a
cell adhesion molecule 2a
chr15_-_21692630 0.88 ENSDART00000039865
sdhdb
succinate dehydrogenase complex, subunit D, integral membrane protein b
chr5_-_67911111 0.88 ENSDART00000051833
gsx1
GS homeobox 1
chr7_-_4107423 0.87 ENSDART00000172971
zgc:55733
zgc:55733
chr22_+_6740039 0.80 ENSDART00000144122
CT583625.2

chr11_+_14104417 0.80 ENSDART00000059752
ENSDART00000186575
med16
mediator complex subunit 16
chr16_+_40024883 0.75 ENSDART00000110100
hint3
histidine triad nucleotide binding protein 3
chr11_-_3613558 0.75 ENSDART00000163578
dnajc16l
DnaJ (Hsp40) homolog, subfamily C, member 16 like
chr3_+_52737565 0.73 ENSDART00000108639
gmip
GEM interacting protein
chr24_+_35787629 0.70 ENSDART00000136721
si:dkeyp-7a3.1
si:dkeyp-7a3.1
chr7_+_41421998 0.69 ENSDART00000083967
chpf2
chondroitin polymerizing factor 2
chr2_+_27386617 0.64 ENSDART00000134976
si:ch73-382f3.1
si:ch73-382f3.1
chr22_+_6843363 0.51 ENSDART00000126044
FO904898.3

chr7_-_35083184 0.46 ENSDART00000100253
ENSDART00000135250
ENSDART00000173511
agrp
agouti related neuropeptide
chr8_+_36270571 0.42 ENSDART00000187505
CU929676.1

chr14_+_1124409 0.41 ENSDART00000190043
ENSDART00000106708
ENSDART00000160246
sec24b
SEC24 homolog B, COPII coat complex component
chr5_-_12824607 0.40 ENSDART00000190310
p2rx2
purinergic receptor P2X, ligand-gated ion channel, 2
chr4_-_77216726 0.30 ENSDART00000099943
psmb10
proteasome subunit beta 10
chr16_-_31985965 0.30 ENSDART00000161944
si:dkey-40m6.14
si:dkey-40m6.14
chr10_-_4961923 0.26 ENSDART00000050177
ENSDART00000146066
snx30
sorting nexin family member 30
chr2_-_51511494 0.25 ENSDART00000161392
ENSDART00000160877
si:ch211-9d9.8
si:ch211-9d9.8
chr8_-_21058354 0.25 ENSDART00000130481
ENSDART00000113749
zgc:112962
zgc:112962
chr21_-_19330333 0.21 ENSDART00000101462
mrps18c
mitochondrial ribosomal protein S18C
chr2_-_39090258 0.19 ENSDART00000134270
ENSDART00000145268
NMNAT3
si:ch73-170l17.1
chr9_+_11587629 0.16 ENSDART00000102508
ENSDART00000146585
si:dkey-69o16.5
si:dkey-69o16.5
chr2_-_51611344 0.14 ENSDART00000158137
si:ch211-9d9.8
si:ch211-9d9.8
chr7_-_61288882 0.12 ENSDART00000098616
ENSDART00000137762
rwdd
RWD domain containing 4
chr9_+_32860345 0.11 ENSDART00000121751
si:dkey-145p14.5
si:dkey-145p14.5
chr12_+_26621906 0.09 ENSDART00000158440
ENSDART00000046959
arhgap12b
Rho GTPase activating protein 12b

Network of associatons between targets according to the STRING database.

First level regulatory network of sox7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.2 GO:0018315 establishment of synaptic specificity at neuromuscular junction(GO:0007529) molybdenum incorporation into molybdenum-molybdopterin complex(GO:0018315) metal incorporation into metallo-molybdopterin complex(GO:0042040) glycine receptor clustering(GO:0072579)
0.7 9.7 GO:0006599 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.5 3.9 GO:0006543 glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543)
0.4 2.2 GO:0060049 regulation of protein glycosylation(GO:0060049)
0.4 4.3 GO:0050714 positive regulation of protein secretion(GO:0050714)
0.2 4.5 GO:0036376 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.2 0.7 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.2 0.9 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.1 1.3 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.1 4.0 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.1 1.0 GO:0034063 stress granule assembly(GO:0034063)
0.1 1.7 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.1 3.7 GO:0014866 skeletal myofibril assembly(GO:0014866)
0.1 6.8 GO:0031290 retinal ganglion cell axon guidance(GO:0031290)
0.1 3.2 GO:0007340 acrosome reaction(GO:0007340)
0.1 1.1 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 2.6 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.1 2.3 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 1.7 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.1 2.0 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 0.6 GO:0032196 transposition(GO:0032196)
0.1 0.5 GO:2000253 adult feeding behavior(GO:0008343) positive regulation of feeding behavior(GO:2000253)
0.0 1.4 GO:0051923 sulfation(GO:0051923)
0.0 0.7 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 3.9 GO:0030865 cortical cytoskeleton organization(GO:0030865)
0.0 0.4 GO:0033198 response to ATP(GO:0033198)
0.0 4.7 GO:0006836 neurotransmitter transport(GO:0006836)
0.0 0.4 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 1.0 GO:0006284 base-excision repair(GO:0006284)
0.0 1.3 GO:0009142 nucleoside triphosphate biosynthetic process(GO:0009142)
0.0 1.7 GO:0090630 activation of GTPase activity(GO:0090630)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.1 1.7 GO:1990246 uniplex complex(GO:1990246)
0.1 2.6 GO:0030667 secretory granule membrane(GO:0030667)
0.1 1.7 GO:0015030 Cajal body(GO:0015030)
0.1 5.5 GO:0032432 actin filament bundle(GO:0032432)
0.1 2.3 GO:0005839 proteasome core complex(GO:0005839)
0.1 5.4 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 1.0 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 3.6 GO:0016592 mediator complex(GO:0016592)
0.0 3.7 GO:0005884 actin filament(GO:0005884)
0.0 1.1 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 5.2 GO:0099572 postsynaptic specialization(GO:0099572)
0.0 0.4 GO:0044453 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0 0.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 1.8 GO:0016607 nuclear speck(GO:0016607)
0.0 0.7 GO:0032580 Golgi cisterna membrane(GO:0032580)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.2 GO:0061599 molybdopterin adenylyltransferase activity(GO:0061598) molybdopterin molybdotransferase activity(GO:0061599)
0.7 9.7 GO:0004111 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.4 4.5 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.4 3.9 GO:0004359 glutaminase activity(GO:0004359)
0.3 1.0 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.3 1.3 GO:0004127 cytidylate kinase activity(GO:0004127)
0.2 2.6 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.2 1.0 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309) double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)
0.2 1.4 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.1 2.0 GO:0016018 cyclosporin A binding(GO:0016018)
0.1 1.3 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 2.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.5 GO:0031781 type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.1 0.9 GO:0048039 ubiquinone binding(GO:0048039)
0.1 3.2 GO:0004629 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.1 0.7 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.1 4.0 GO:0017124 SH3 domain binding(GO:0017124)
0.1 2.1 GO:0004707 MAP kinase activity(GO:0004707)
0.1 2.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 1.7 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 51.5 GO:0005509 calcium ion binding(GO:0005509)
0.0 5.7 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.4 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 1.4 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 3.9 GO:0019901 protein kinase binding(GO:0019901)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.1 1.3 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.5 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 1.5 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.7 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 2.3 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 1.1 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.7 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 3.6 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.3 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.4 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC