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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for sox8a+sox8b

Z-value: 0.52

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Transcription factors associated with sox8a+sox8b

Gene Symbol Gene ID Gene Info
sox8b
ENSDARG00000037782 SRY-box transcription factor 8b
sox8a
ENSDARG00000105301 SRY-box transcription factor 8a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
sox8bdr11_v1_chr3_-_62403550_624035500.487.9e-07Click!
sox8adr11_v1_chr12_-_1085227_10852270.431.3e-05Click!

Activity profile of sox8a+sox8b motif

Sorted Z-values of sox8a+sox8b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_38786298 8.58 ENSDART00000164440
si:ch211-195b11.3
si:ch211-195b11.3
chr3_-_27647845 4.27 ENSDART00000151625
si:ch211-157c3.4
si:ch211-157c3.4
chr3_-_5067585 4.08 ENSDART00000169609
tefb
thyrotrophic embryonic factor b
chr4_+_18843015 3.64 ENSDART00000152086
ENSDART00000066977
ENSDART00000132567
bik
BCL2 interacting killer
chr14_+_11457500 3.10 ENSDART00000169202
si:ch211-153b23.5
si:ch211-153b23.5
chr21_-_43328056 2.50 ENSDART00000114955
sowahaa
sosondowah ankyrin repeat domain family member Aa
chr22_-_38621438 2.49 ENSDART00000098330
nppc
natriuretic peptide C
chr14_+_48862987 2.42 ENSDART00000167810
zgc:154054
zgc:154054
chr6_-_37743724 2.27 ENSDART00000149068
nipa2
non imprinted in Prader-Willi/Angelman syndrome 2 (human)
chr12_+_30705769 2.24 ENSDART00000186448
ENSDART00000066259
kcnk1a
potassium channel, subfamily K, member 1a
chr9_+_41156818 2.19 ENSDART00000105764
ENSDART00000147052
stat4
signal transducer and activator of transcription 4
chr7_+_17096281 2.18 ENSDART00000035558
htatip2
HIV-1 Tat interactive protein 2
chr2_-_24554416 2.11 ENSDART00000052061
cnn2
calponin 2
chr12_-_11593436 2.05 ENSDART00000138954
plekha1b
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1b
chr12_+_30706158 1.99 ENSDART00000133869
kcnk1a
potassium channel, subfamily K, member 1a
chr5_+_45008418 1.92 ENSDART00000189882
dmrt2a
doublesex and mab-3 related transcription factor 2a
chr19_-_11950434 1.77 ENSDART00000024861
cpsf1
cleavage and polyadenylation specific factor 1
chr5_+_31214341 1.76 ENSDART00000133432
atp2a3
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
chr20_-_13673566 1.73 ENSDART00000181641
TAGAP
si:ch211-122h15.4
chr22_+_9522971 1.67 ENSDART00000110048
strip1
striatin interacting protein 1
chr10_-_7386475 1.55 ENSDART00000167963
nrg1
neuregulin 1
chr21_+_43328685 1.54 ENSDART00000109620
ENSDART00000139668
sept8a
septin 8a
chr19_-_11949996 1.53 ENSDART00000163478
ENSDART00000167299
cpsf1
cleavage and polyadenylation specific factor 1
chr6_+_13506841 1.50 ENSDART00000032331
gmppab
GDP-mannose pyrophosphorylase Ab
chr20_-_37522569 1.47 ENSDART00000177011
ENSDART00000058502
hivep2a
human immunodeficiency virus type I enhancer binding protein 2a
chr1_-_23308225 1.46 ENSDART00000137567
ENSDART00000008201
smim14
small integral membrane protein 14
chr19_+_11432330 1.43 ENSDART00000188065
PQLC1
PQ loop repeat containing 1
chr19_+_3653976 1.37 ENSDART00000125673
nedd9
neural precursor cell expressed, developmentally down-regulated 9
chr3_+_32663865 1.36 ENSDART00000190240
si:dkey-16l2.16
si:dkey-16l2.16
chr3_+_3573696 1.24 ENSDART00000169680
CR589947.2

chr3_+_45687266 1.22 ENSDART00000131652
gpr146
G protein-coupled receptor 146
chr20_-_39273505 1.17 ENSDART00000153114
clu
clusterin
chr15_+_28368823 1.15 ENSDART00000142298
slc43a2a
solute carrier family 43 (amino acid system L transporter), member 2a
chr17_+_24687338 1.11 ENSDART00000135794
selenon
selenoprotein N
chr5_-_6567464 1.05 ENSDART00000184985
tnks1bp1
tankyrase 1 binding protein 1
chr7_+_25003851 1.05 ENSDART00000144526
naa40
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr2_-_22492289 1.02 ENSDART00000168022
gtf2b
general transcription factor IIB
chr8_+_41238064 0.99 ENSDART00000111321
zgc:152830
zgc:152830
chr20_-_39273987 0.93 ENSDART00000127173
clu
clusterin
chr12_+_34258139 0.93 ENSDART00000153127
socs3b
suppressor of cytokine signaling 3b
chr6_+_7322587 0.89 ENSDART00000065500
abcc4
ATP-binding cassette, sub-family C (CFTR/MRP), member 4
chr8_+_42718135 0.88 ENSDART00000158900
zgc:194007
zgc:194007
chr10_+_5268054 0.84 ENSDART00000114491
ror2
receptor tyrosine kinase-like orphan receptor 2
chr15_-_43327911 0.84 ENSDART00000077386
prss16
protease, serine, 16 (thymus)
chr20_-_29505863 0.80 ENSDART00000148278
klf11a
Kruppel-like factor 11a
chr15_+_28368644 0.79 ENSDART00000168453
slc43a2a
solute carrier family 43 (amino acid system L transporter), member 2a
chr21_+_42717424 0.78 ENSDART00000166936
ENSDART00000172135
sh3pxd2b
SH3 and PX domains 2B
chr2_+_8031234 0.78 ENSDART00000156321
ENSDART00000040111
pcolce2a
procollagen C-endopeptidase enhancer 2a
chr7_-_18547420 0.78 ENSDART00000173969
rgs12a
regulator of G protein signaling 12a
chr25_-_37248795 0.76 ENSDART00000087247
ENSDART00000154045
glg1a
golgi glycoprotein 1a
chr14_+_597532 0.75 ENSDART00000159805
LO018568.2

chr23_-_36418708 0.73 ENSDART00000132273
znf740b
zinc finger protein 740b
chr8_-_7603516 0.70 ENSDART00000179826
ENSDART00000190153
irak1
interleukin-1 receptor-associated kinase 1
chr9_-_3934963 0.68 ENSDART00000062336
ubr3
ubiquitin protein ligase E3 component n-recognin 3
chr8_-_7603700 0.68 ENSDART00000137975
irak1
interleukin-1 receptor-associated kinase 1
chr4_+_37952218 0.67 ENSDART00000186865
si:dkeyp-82b4.2
si:dkeyp-82b4.2
chr9_-_8979154 0.67 ENSDART00000145266
ing1
inhibitor of growth family, member 1
chr2_+_51645164 0.65 ENSDART00000169600
abhd4
abhydrolase domain containing 4
chr8_+_10862353 0.64 ENSDART00000140717
brpf3b
bromodomain and PHD finger containing, 3b
chr10_+_9595575 0.64 ENSDART00000091780
ENSDART00000184287
rc3h2
ring finger and CCCH-type domains 2
chr3_-_1859198 0.63 ENSDART00000121870
micall1b.2
MICAL like 1b, duplicate 2
chr9_-_8979468 0.62 ENSDART00000134646
ing1
inhibitor of growth family, member 1
chr6_-_48347724 0.61 ENSDART00000046973
capza1a
capping protein (actin filament) muscle Z-line, alpha 1a
chr2_+_15048410 0.58 ENSDART00000058484
cnn3b
calponin 3, acidic b
chr16_-_21047872 0.55 ENSDART00000131582
cbx3b
chromobox homolog 3b
chr16_+_25095483 0.54 ENSDART00000155032
si:ch211-261d7.3
si:ch211-261d7.3
chr13_-_8892514 0.53 ENSDART00000144553
plekhh2
pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr16_-_21047483 0.47 ENSDART00000136235
cbx3b
chromobox homolog 3b
chr14_+_6546516 0.46 ENSDART00000097214
adam19b
ADAM metallopeptidase domain 19b
chr11_-_45138857 0.43 ENSDART00000166501
cant1b
calcium activated nucleotidase 1b
chr11_-_43226255 0.42 ENSDART00000172929
sptbn1
spectrin, beta, non-erythrocytic 1
chr3_+_62327332 0.42 ENSDART00000158414
BX470259.1

chr4_-_39186893 0.41 ENSDART00000150371
ENSDART00000121804
ENSDART00000133901
si:ch211-22k7.9
si:ch211-22k7.9
chr12_+_18544159 0.41 ENSDART00000162900
mlst8
MTOR associated protein, LST8 homolog (S. cerevisiae)
chr20_+_30578967 0.41 ENSDART00000010494
fgfr1op
FGFR1 oncogene partner
chr5_-_54300725 0.41 ENSDART00000163048
slc25a35
solute carrier family 25, member 35
chr17_+_24604373 0.37 ENSDART00000082193
zmpste24
zinc metallopeptidase, STE24 homolog
chr1_-_16688965 0.35 ENSDART00000079001
ENSDART00000178599
frg1
FSHD region gene 1
chr13_-_44423 0.35 ENSDART00000093247
gtf2a1l
general transcription factor IIA, 1-like
chr19_-_24198139 0.33 ENSDART00000138864
ENSDART00000125350
prf1.7
perforin 1.7
chr9_+_23714406 0.29 ENSDART00000189445
gypc
glycophorin C (Gerbich blood group)
chr10_+_11398111 0.29 ENSDART00000064210
cwc27
CWC27 spliceosome-associated protein homolog (S. cerevisiae)
chr20_-_3276339 0.28 ENSDART00000166831
rps6kc1
ribosomal protein S6 kinase polypeptide 1
chr11_-_30138299 0.27 ENSDART00000172106
scml2
Scm polycomb group protein like 2
chr3_+_39579393 0.27 ENSDART00000055170
cln3
ceroid-lipofuscinosis, neuronal 3
chr11_-_18015534 0.26 ENSDART00000181953
qrich1
glutamine-rich 1
chr2_+_24770435 0.24 ENSDART00000078854
mpv17l2
MPV17 mitochondrial membrane protein-like 2
chr19_+_27448625 0.23 ENSDART00000052352
ppp1r11
protein phosphatase 1, regulatory (inhibitor) subunit 11
chr7_+_73780936 0.23 ENSDART00000092691
pea15
proliferation and apoptosis adaptor protein 15
chr10_-_14545658 0.20 ENSDART00000057865
ier3ip1
immediate early response 3 interacting protein 1
chr25_+_4787431 0.20 ENSDART00000170640
myo5c
myosin VC
chr23_-_35694171 0.19 ENSDART00000077539
tuba1c
tubulin, alpha 1c
chr10_-_43334914 0.19 ENSDART00000146660
ENSDART00000190288
hapln1b
hyaluronan and proteoglycan link protein 1b
chr15_+_3125136 0.18 ENSDART00000130968
rcbtb2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr7_-_50410524 0.16 ENSDART00000083346
hypk
huntingtin interacting protein K
chr5_-_28559870 0.16 ENSDART00000154495
FP015972.1

chr4_+_39766931 0.15 ENSDART00000138663
si:dkeyp-85d8.1
si:dkeyp-85d8.1
chr17_+_38476300 0.13 ENSDART00000123298
stard9
StAR-related lipid transfer (START) domain containing 9
chr7_+_52753067 0.11 ENSDART00000053814
mtfmt
mitochondrial methionyl-tRNA formyltransferase
chr18_+_45666489 0.11 ENSDART00000180147
ENSDART00000151351
prrg4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr4_+_6833583 0.07 ENSDART00000165179
ENSDART00000186134
ENSDART00000174507
dock4b
dedicator of cytokinesis 4b
chr4_+_22297839 0.05 ENSDART00000077707
llph
LLP homolog, long-term synaptic facilitation (Aplysia)
chr7_-_38792543 0.04 ENSDART00000157416
si:dkey-23n7.10
si:dkey-23n7.10

Network of associatons between targets according to the STRING database.

First level regulatory network of sox8a+sox8b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0060959 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) Schwann cell migration(GO:0036135) cardiac neuron differentiation(GO:0060945) cardiac neuron development(GO:0060959)
0.3 1.4 GO:0090527 actin filament reorganization(GO:0090527)
0.3 1.5 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.2 4.2 GO:0030322 stabilization of membrane potential(GO:0030322)
0.2 1.1 GO:0050848 regulation of calcium-mediated signaling(GO:0050848)
0.2 1.4 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
0.1 0.7 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 2.3 GO:0015693 magnesium ion transport(GO:0015693)
0.1 0.8 GO:0071800 podosome assembly(GO:0071800)
0.1 0.4 GO:0071586 CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
0.1 3.3 GO:0043631 mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631)
0.1 2.5 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 1.0 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.1 2.1 GO:0043535 regulation of blood vessel endothelial cell migration(GO:0043535)
0.1 1.0 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.1 3.6 GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043280)
0.1 3.1 GO:0097696 JAK-STAT cascade(GO:0007259) STAT cascade(GO:0097696)
0.1 0.2 GO:0061668 mitochondrial ribosome assembly(GO:0061668)
0.1 4.1 GO:0071482 cellular response to light stimulus(GO:0071482)
0.1 1.9 GO:0015804 neutral amino acid transport(GO:0015804)
0.1 1.9 GO:0007548 sex differentiation(GO:0007548)
0.0 5.8 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 0.9 GO:0098754 detoxification(GO:0098754)
0.0 0.6 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.0 2.0 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.3 GO:0015802 basic amino acid transport(GO:0015802) arginine transport(GO:0015809)
0.0 0.7 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0 0.8 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068)
0.0 2.1 GO:1901214 regulation of neuron death(GO:1901214)
0.0 0.2 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 2.4 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 2.0 GO:0051170 nuclear import(GO:0051170)
0.0 1.7 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.5 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 1.5 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 1.0 GO:0051693 actin filament capping(GO:0051693)
0.0 3.1 GO:0006914 autophagy(GO:0006914)
0.0 1.3 GO:0008285 negative regulation of cell proliferation(GO:0008285)
0.0 0.6 GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:0000288)
0.0 0.3 GO:0019835 cytolysis(GO:0019835)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.1 GO:0042583 chromaffin granule(GO:0042583)
0.2 3.3 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.2 0.6 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 1.0 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 4.2 GO:0043204 perikaryon(GO:0043204)
0.1 0.3 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.1 0.4 GO:0008091 spectrin(GO:0008091)
0.1 1.8 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 0.8 GO:0002102 podosome(GO:0002102)
0.1 0.4 GO:0031931 TORC1 complex(GO:0031931)
0.0 1.5 GO:0005940 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 2.4 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.6 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 4.5 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 0.3 GO:0071005 U2-type precatalytic spliceosome(GO:0071005)
0.0 0.4 GO:0015030 Cajal body(GO:0015030)
0.0 0.9 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.3 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.6 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.9 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.7 GO:0005811 lipid particle(GO:0005811)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.5 GO:0004475 mannose-1-phosphate guanylyltransferase activity(GO:0004475) mannose-phosphate guanylyltransferase activity(GO:0008905)
0.3 0.9 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.3 4.2 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.3 1.0 GO:0043998 H2A histone acetyltransferase activity(GO:0043998)
0.2 1.0 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046) core promoter binding(GO:0001047)
0.1 1.6 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.1 2.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 1.8 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 0.6 GO:0035613 RNA stem-loop binding(GO:0035613)
0.1 0.8 GO:0016176 superoxide-generating NADPH oxidase activity(GO:0016175) superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 2.1 GO:0051787 misfolded protein binding(GO:0051787)
0.0 5.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.4 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.8 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 1.9 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.6 GO:0043994 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.0 1.3 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.7 GO:0042171 lysophosphatidic acid acyltransferase activity(GO:0042171)
0.0 1.0 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 2.5 GO:0051427 hormone receptor binding(GO:0051427)
0.0 2.4 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 0.9 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.8 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.2 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.4 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.0 2.6 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.1 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0 0.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 1.6 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 1.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 2.1 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.8 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.4 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.2 3.3 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.2 1.6 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 1.8 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 1.0 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 3.0 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.4 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.0 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.4 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 1.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.2 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway