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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for tbx20

Z-value: 0.89

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Transcription factors associated with tbx20

Gene Symbol Gene ID Gene Info
tbx20
ENSDARG00000005150 T-box transcription factor 20

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tbx20dr11_v1_chr16_-_42523744_42523744-0.261.1e-02Click!

Activity profile of tbx20 motif

Sorted Z-values of tbx20 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_32228538 27.20 ENSDART00000077471
myhc4
myosin heavy chain 4
chr13_-_293250 15.02 ENSDART00000138581
chs1
chitin synthase 1
chr9_+_23900703 14.67 ENSDART00000127859
trim63b
tripartite motif containing 63b
chr8_-_11112058 13.53 ENSDART00000042755
ampd1
adenosine monophosphate deaminase 1 (isoform M)
chr7_-_69853453 11.75 ENSDART00000049928
myoz2a
myozenin 2a
chr20_+_826459 11.55 ENSDART00000104740
nt5e
5'-nucleotidase, ecto (CD73)
chr7_+_39389273 10.81 ENSDART00000191298
tnni2b.2
troponin I type 2b (skeletal, fast), tandem duplicate 2
chr1_-_59360114 9.11 ENSDART00000160445
CABZ01052573.1

chr2_-_51109476 8.49 ENSDART00000168286
si:ch73-52e5.1
si:ch73-52e5.1
chr21_+_30351256 7.76 ENSDART00000078341
foxi3a
forkhead box I3a
chr24_+_13869092 5.65 ENSDART00000176492
eya1
EYA transcriptional coactivator and phosphatase 1
chr15_-_41689684 5.14 ENSDART00000143447
spsb4b
splA/ryanodine receptor domain and SOCS box containing 4b
chr14_+_20911310 4.70 ENSDART00000160318
lygl2
lysozyme g-like 2
chr5_-_44843738 3.99 ENSDART00000003926
fbp1a
fructose-1,6-bisphosphatase 1a
chr1_-_462165 3.98 ENSDART00000152799
si:ch73-244f7.3
si:ch73-244f7.3
chr15_-_47479119 3.94 ENSDART00000164957
inppl1a
inositol polyphosphate phosphatase-like 1a
chr17_+_26965351 3.91 ENSDART00000114215
ENSDART00000147192
grhl3
grainyhead-like transcription factor 3
chr25_+_18475032 3.47 ENSDART00000073564
tes
testis derived transcript (3 LIM domains)
chr11_+_45233348 3.27 ENSDART00000173150
tmc6b
transmembrane channel-like 6b
chr12_+_48340133 3.24 ENSDART00000152899
ENSDART00000153335
ENSDART00000054788
ddit4
DNA-damage-inducible transcript 4
chr7_+_6879534 3.22 ENSDART00000157731
zgc:175248
zgc:175248
chr23_-_27479558 3.19 ENSDART00000013563
atf7a
activating transcription factor 7a
chr21_-_36948 3.00 ENSDART00000181230
JMY
junction mediating and regulatory protein, p53 cofactor
chr22_+_20710434 2.99 ENSDART00000135521
peak3
PEAK family member 3
chr11_+_24729346 2.62 ENSDART00000087740
zgc:153953
zgc:153953
chr8_+_36416285 2.58 ENSDART00000158400
si:busm1-194e12.8
si:busm1-194e12.8
chr7_-_5070794 2.55 ENSDART00000097877
ltb4r2a
leukotriene B4 receptor 2a
chr19_+_177455 2.35 ENSDART00000111580
tmem65
transmembrane protein 65
chr7_+_40081630 2.27 ENSDART00000173559
zgc:112356
zgc:112356
chr20_+_15600167 2.22 ENSDART00000171991
faslg
Fas ligand (TNF superfamily, member 6)
chr22_+_978867 2.16 ENSDART00000148981
def6b
differentially expressed in FDCP 6b homolog (mouse)
chr2_-_16216568 2.01 ENSDART00000173758
arhgef4
Rho guanine nucleotide exchange factor (GEF) 4
chr3_-_8285123 1.96 ENSDART00000158699
ENSDART00000138588
trim35-9
tripartite motif containing 35-9
chr24_+_26742226 1.92 ENSDART00000079721
ghsrb
growth hormone secretagogue receptor b
chr25_+_37130450 1.87 ENSDART00000183358
si:ch1073-174d20.1
si:ch1073-174d20.1
chr15_+_31515976 1.79 ENSDART00000156471
tex26
testis expressed 26
chr2_-_37797577 1.75 ENSDART00000110781
nfatc4
nuclear factor of activated T cells 4
chr4_+_35138928 1.73 ENSDART00000167934
ENSDART00000192116
ENSDART00000183689
si:dkey-279j5.1
si:dkey-279j5.1
chr12_+_763051 1.67 ENSDART00000152579
abcc3
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
chr7_+_48675347 1.65 ENSDART00000157917
ENSDART00000185580
trpm5
transient receptor potential cation channel, subfamily M, member 5
chr16_+_12660477 1.63 ENSDART00000016834
aicda
activation-induced cytidine deaminase
chr11_-_26832685 1.63 ENSDART00000153519
iqsec1b
IQ motif and Sec7 domain 1b
chr21_+_5494561 1.59 ENSDART00000169728
ly6m3
lymphocyte antigen 6 family member M3
chr4_-_13509946 1.45 ENSDART00000134720
ifng1-2
interferon, gamma 1-2
chr24_-_41220538 1.42 ENSDART00000150207
acvr2ba
activin A receptor type 2Ba
chr24_+_42948 1.26 ENSDART00000122785
tmx3b
thioredoxin related transmembrane protein 3b
chr4_-_50207986 1.26 ENSDART00000150388
si:ch211-197e7.3
si:ch211-197e7.3
chr11_-_12104917 1.23 ENSDART00000136108
mrpl45
mitochondrial ribosomal protein L45
chr16_-_7379328 1.18 ENSDART00000060447
med18
mediator of RNA polymerase II transcription, subunit 18 homolog (yeast)
chr7_-_40082053 1.15 ENSDART00000083719
ENSDART00000173687
shrprbck1r
sharpin and rbck1 related
chr11_-_44622240 1.13 ENSDART00000172258
ENSDART00000173340
tbce
tubulin folding cofactor E
chr25_-_35107791 1.13 ENSDART00000192819
zgc:165555
zgc:165555
chr14_+_80685 1.12 ENSDART00000188443
stag3
stromal antigen 3
chr20_-_116999 1.10 ENSDART00000149581
ypel5
yippee-like 5
chr7_+_756942 1.09 ENSDART00000152224
zgc:63470
zgc:63470
chr25_+_37285737 1.02 ENSDART00000126879
tmed6
transmembrane p24 trafficking protein 6
chr15_+_43799258 1.01 ENSDART00000122238
tyr
tyrosinase
chr12_-_43664682 0.94 ENSDART00000159423
foxi1
forkhead box i1
chr4_+_32156734 0.91 ENSDART00000163904
CR450785.1

chr12_+_17933775 0.77 ENSDART00000186047
ENSDART00000160586
trrap
transformation/transcription domain-associated protein
chr7_+_69449814 0.75 ENSDART00000109644
ctdnep1b
CTD nuclear envelope phosphatase 1b
chr8_-_42677086 0.75 ENSDART00000191173
si:ch73-138n13.1
si:ch73-138n13.1
chr15_+_33696559 0.73 ENSDART00000188248
ENSDART00000161951
hdac12
histone deacetylase 12
chr12_+_19362547 0.70 ENSDART00000180148
gspt1
G1 to S phase transition 1
chr3_+_52475058 0.70 ENSDART00000035867
si:ch211-241f5.3
si:ch211-241f5.3
chr5_-_36549024 0.68 ENSDART00000097671
zgc:158432
zgc:158432
chr4_-_75812937 0.67 ENSDART00000125096
si:ch211-203c5.3
si:ch211-203c5.3
chr22_-_35385810 0.66 ENSDART00000111824
HTR3C
5-hydroxytryptamine receptor 3C
chr10_+_42589707 0.65 ENSDART00000075269
fgfr1b
fibroblast growth factor receptor 1b
chr3_-_7940522 0.63 ENSDART00000159710
ENSDART00000167201
trim35-25
tripartite motif containing 35-25
chr5_-_49012569 0.57 ENSDART00000184690
si:dkey-172m14.2
si:dkey-172m14.2
chr4_-_18840919 0.55 ENSDART00000015834
cbll1
Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
chr22_-_37796998 0.48 ENSDART00000124742
ENSDART00000191232
acap2
ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
chr23_-_18381361 0.41 ENSDART00000016891
hsd17b10
hydroxysteroid (17-beta) dehydrogenase 10
chr8_+_30747940 0.39 ENSDART00000098975
p2rx4b
purinergic receptor P2X, ligand-gated ion channel, 4b
chr5_-_26323137 0.35 ENSDART00000133823
arvcfb
ARVCF, delta catenin family member b
chr3_-_5555500 0.27 ENSDART00000176133
ENSDART00000057464
trim35-31
tripartite motif containing 35-31
chr3_-_47036951 0.25 ENSDART00000186971
CR392045.1

chr4_+_38103421 0.23 ENSDART00000164164
znf1016
zinc finger protein 1016
chr3_+_17314997 0.20 ENSDART00000139763
stat5a
signal transducer and activator of transcription 5a
chr18_-_51015718 0.16 ENSDART00000190698
LO018598.1

chr4_+_59234719 0.13 ENSDART00000170724
ENSDART00000192143
ENSDART00000109914
znf1086
zinc finger protein 1086
chr21_-_12749501 0.05 ENSDART00000179724
LO018011.1

chr1_-_58913813 0.00 ENSDART00000056494
zgc:171687
zgc:171687

Network of associatons between targets according to the STRING database.

First level regulatory network of tbx20

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 15.0 GO:1901073 chitin biosynthetic process(GO:0006031) glucosamine-containing compound biosynthetic process(GO:1901073)
2.2 8.7 GO:0009957 epidermal cell fate specification(GO:0009957)
1.9 11.6 GO:0009169 purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
1.6 4.7 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
1.3 4.0 GO:0005986 sucrose metabolic process(GO:0005985) sucrose biosynthetic process(GO:0005986) disaccharide biosynthetic process(GO:0046351)
1.0 13.5 GO:0032264 IMP salvage(GO:0032264)
0.8 2.4 GO:1903779 regulation of cardiac conduction(GO:1903779)
0.6 5.7 GO:2001240 histone dephosphorylation(GO:0016576) negative regulation of signal transduction in absence of ligand(GO:1901099) regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001239) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.6 3.9 GO:0071623 negative regulation of leukocyte chemotaxis(GO:0002689) negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024) negative regulation of neutrophil migration(GO:1902623)
0.4 2.6 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
0.4 1.6 GO:0016554 cytidine to uridine editing(GO:0016554)
0.3 1.0 GO:0042416 dopamine biosynthetic process from tyrosine(GO:0006585) dopamine biosynthetic process(GO:0042416)
0.3 1.3 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
0.3 3.9 GO:0060325 face morphogenesis(GO:0060325)
0.2 1.1 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.2 10.8 GO:0003009 skeletal muscle contraction(GO:0003009)
0.2 4.0 GO:0018023 peptidyl-lysine trimethylation(GO:0018023)
0.2 1.2 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.2 1.7 GO:0050909 sensory perception of taste(GO:0050909)
0.1 0.7 GO:0010867 regulation of triglyceride biosynthetic process(GO:0010866) positive regulation of triglyceride biosynthetic process(GO:0010867)
0.1 0.7 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.1 1.7 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.1 2.2 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.1 3.2 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 0.2 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0 1.6 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.8 GO:0035675 neuromast hair cell development(GO:0035675)
0.0 0.4 GO:0033198 response to ATP(GO:0033198)
0.0 1.4 GO:0032924 activin receptor signaling pathway(GO:0032924)
0.0 21.2 GO:0016567 protein ubiquitination(GO:0016567)
0.0 1.1 GO:0007062 sister chromatid cohesion(GO:0007062)
0.0 0.7 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.0 1.1 GO:0006334 nucleosome assembly(GO:0006334)
0.0 1.0 GO:0007030 Golgi organization(GO:0007030)
0.0 0.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 15.0 GO:0030428 cell septum(GO:0030428)
0.3 2.6 GO:0042613 MHC class II protein complex(GO:0042613)
0.3 10.8 GO:0005861 troponin complex(GO:0005861)
0.2 23.6 GO:0016459 myosin complex(GO:0016459)
0.2 11.6 GO:0031225 anchored component of membrane(GO:0031225)
0.2 1.2 GO:0070847 core mediator complex(GO:0070847)
0.1 0.7 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.1 0.7 GO:0018444 translation release factor complex(GO:0018444)
0.1 1.1 GO:0071797 LUBAC complex(GO:0071797)
0.1 11.8 GO:0030018 Z disc(GO:0030018)
0.1 1.4 GO:0048179 activin receptor complex(GO:0048179)
0.1 1.0 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 5.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 3.2 GO:0030175 filopodium(GO:0030175)
0.1 0.8 GO:0000124 SAGA complex(GO:0000124)
0.0 1.1 GO:0008278 cohesin complex(GO:0008278)
0.0 3.5 GO:0005925 focal adhesion(GO:0005925)
0.0 0.4 GO:0044453 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0 1.9 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 1.0 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 20.6 GO:0005829 cytosol(GO:0005829)
0.0 1.2 GO:0005840 ribosome(GO:0005840)
0.0 1.1 GO:0000786 nucleosome(GO:0000786)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 15.0 GO:0004100 chitin synthase activity(GO:0004100)
1.3 4.0 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
1.2 13.5 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
1.2 11.8 GO:0051373 telethonin binding(GO:0031433) FATZ binding(GO:0051373)
1.2 4.7 GO:0003796 lysozyme activity(GO:0003796)
0.8 3.2 GO:0071889 14-3-3 protein binding(GO:0071889)
0.6 11.6 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.4 2.5 GO:0004974 leukotriene receptor activity(GO:0004974)
0.3 1.0 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.2 1.6 GO:0004126 cytidine deaminase activity(GO:0004126)
0.2 1.3 GO:0016972 thiol oxidase activity(GO:0016972)
0.2 3.2 GO:0035497 cAMP response element binding(GO:0035497)
0.1 3.3 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 23.6 GO:0003774 motor activity(GO:0003774)
0.1 1.4 GO:0017002 activin-activated receptor activity(GO:0017002)
0.1 0.7 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.1 2.2 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 1.7 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.1 0.7 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 18.0 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 3.7 GO:0016279 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.0 0.4 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 3.9 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 3.7 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 1.1 GO:0043130 ubiquitin binding(GO:0043130)
0.0 1.7 GO:0042626 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.3 11.6 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 7.0 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 2.0 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 1.7 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 1.8 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.5 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.5 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 11.6 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
1.4 13.5 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.3 2.2 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.3 1.7 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 2.0 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 1.1 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.7 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.4 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.2 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling