Project

PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

Navigation
Downloads

Results for tbx5a+tbx5b

Z-value: 0.91

Motif logo

Transcription factors associated with tbx5a+tbx5b

Gene Symbol Gene ID Gene Info
ENSDARG00000024894 T-box transcription factor 5a
ENSDARG00000092060 T-box transcription factor 5b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tbx5bdr11_v1_chr5_+_23152282_23152282-0.188.5e-02Click!
tbx5adr11_v1_chr5_-_72289648_72289648-0.151.5e-01Click!

Activity profile of tbx5a+tbx5b motif

Sorted Z-values of tbx5a+tbx5b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_32526263 14.14 ENSDART00000150897
si:ch73-367p23.2
chr21_+_30351256 11.44 ENSDART00000078341
forkhead box I3a
chr3_+_32526799 10.28 ENSDART00000185755
si:ch73-367p23.2
chr2_+_2470687 10.24 ENSDART00000184024
ENSDART00000061955
myosin, light chain 13
chr13_-_7031033 10.02 ENSDART00000193211

chr6_-_46941245 9.68 ENSDART00000037875
immunoglobulin-like and fibronectin type III domain containing 1, tandem duplicate 1
chr7_+_22680560 7.26 ENSDART00000133761
plac8 onzin related protein 4
chr18_+_5547185 6.86 ENSDART00000193977
nicotinamide nucleotide transhydrogenase 2
chr21_+_20383837 6.80 ENSDART00000026430
heat shock protein, alpha-crystallin-related, b11
chr17_-_15611744 6.40 ENSDART00000010496
four and a half LIM domains 5
chr9_+_23900703 6.38 ENSDART00000127859
tripartite motif containing 63b
chr5_+_57658898 5.98 ENSDART00000074268
ENSDART00000124568
zgc:153929
chr23_-_10254288 5.91 ENSDART00000081215
keratin 8
chr24_-_33703504 5.88 ENSDART00000079292
caveolae associated protein 4b
chr14_-_17121676 5.77 ENSDART00000170154
ENSDART00000060479
smoothelin-like 1
chr10_+_8968203 5.63 ENSDART00000110443
ENSDART00000080772
follistatin b
chr15_+_32711663 5.49 ENSDART00000157854
ENSDART00000167515
periostin, osteoblast specific factor b
chr11_+_27347076 5.47 ENSDART00000173383
fibulin 2
chr19_+_19777437 5.44 ENSDART00000170662
homeobox A3a
chr8_-_11229523 5.42 ENSDART00000002164
unc-45 myosin chaperone B
chr15_+_32711172 5.39 ENSDART00000163936
ENSDART00000168135
periostin, osteoblast specific factor b
chr17_+_2549503 5.34 ENSDART00000156843
si:dkey-248g15.3
chr15_-_551177 5.26 ENSDART00000066774
ENSDART00000154617
transgelin
chr11_+_29537756 5.25 ENSDART00000103388
wu:fi42e03
chr17_+_26965351 5.24 ENSDART00000114215
ENSDART00000147192
grainyhead-like transcription factor 3
chr23_-_10175898 5.02 ENSDART00000146185
keratin 5
chr2_+_24304854 4.99 ENSDART00000078972
fat storage-inducing transmembrane protein 1
chr24_-_10006158 4.96 ENSDART00000106244
zgc:171750
chr5_+_6670945 4.91 ENSDART00000185686
paxillin a
chr3_-_12187245 4.85 ENSDART00000189553
ENSDART00000165131
sarcalumenin
chr1_-_59104145 4.73 ENSDART00000132495
ENSDART00000152457
si:zfos-2330d3.1
si:zfos-2330d3.7
chr24_-_9997948 4.66 ENSDART00000136274
si:ch211-146l10.7
chr24_-_10021341 4.66 ENSDART00000137250
zgc:173856
chr3_+_43086548 4.62 ENSDART00000163579
si:dkey-43p13.5
chr23_+_44614056 4.61 ENSDART00000188379
enolase 3, (beta, muscle)
chr16_-_31469065 4.58 ENSDART00000182397
si:ch211-251p5.5
chr8_+_33035709 4.57 ENSDART00000131660
angiopoietin-like 2b
chr5_+_26213874 4.50 ENSDART00000193816
ENSDART00000098514
occludin b
chr19_-_34999379 4.46 ENSDART00000051751
zgc:113424
chr21_-_131236 4.45 ENSDART00000160005
si:ch1073-398f15.1
chr24_+_10027902 4.43 ENSDART00000175961
ENSDART00000172773
si:ch211-146l10.8
chr5_-_38451082 4.37 ENSDART00000136428
cholinergic receptor, nicotinic, epsilon
chr3_+_49397115 4.23 ENSDART00000176042
trans-2,3-enoyl-CoA reductase a
chr10_+_19596214 4.20 ENSDART00000183110

chr19_-_38611814 4.19 ENSDART00000151958
collagen, type XVI, alpha 1
chr9_+_31795343 4.17 ENSDART00000139584
integrin, beta-like 1
chr25_+_20077225 4.16 ENSDART00000136543
troponin I4b, tandem duplicate 1
chr9_-_98982 4.15 ENSDART00000147882
LIM and senescent cell antigen-like domains 2
chr6_+_56141852 4.14 ENSDART00000149665
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
chr25_+_8356707 4.12 ENSDART00000153708
mucin 5.1, oligomeric mucus/gel-forming
chr20_-_26001288 4.06 ENSDART00000136518
ENSDART00000063177
calpain 3b
chr21_+_21374277 3.99 ENSDART00000079431
reticulon 2b
chr2_+_36007449 3.93 ENSDART00000161837
laminin, gamma 2
chr23_-_32156278 3.89 ENSDART00000157479
nuclear receptor subfamily 4, group A, member 1
chr18_+_23373683 3.89 ENSDART00000001102
ENSDART00000189030
multiple C2 domains, transmembrane 2a
chr24_+_35564668 3.86 ENSDART00000122734
CCAAT/enhancer binding protein (C/EBP), delta
chr16_+_3982590 3.85 ENSDART00000149295
zinc finger CCCH-type containing 12A
chr20_-_43743700 3.83 ENSDART00000100620
si:dkeyp-50f7.2
chr8_+_2478862 3.79 ENSDART00000131739
si:dkeyp-51b9.3
chr14_+_49251331 3.74 ENSDART00000148882
annexin A6
chr19_-_5332784 3.73 ENSDART00000010373
keratin, type 1, gene 19d
chr19_+_791538 3.70 ENSDART00000146554
ENSDART00000138406
transmembrane protein 79a
chr8_-_24252933 3.69 ENSDART00000057624
zgc:110353
chr1_+_58205904 3.69 ENSDART00000147324
si:dkey-222h21.12
chr7_+_15329819 3.66 ENSDART00000006018
mesoderm posterior aa
chr17_+_24843401 3.66 ENSDART00000110179
connexin 34.4
chr21_+_25187210 3.64 ENSDART00000101147
ENSDART00000167528
si:dkey-183i3.5
chr19_-_2861444 3.62 ENSDART00000169053
C-type lectin domain family 3, member Bb
chr7_-_2047639 3.61 ENSDART00000173892
si:cabz01007794.1
chr12_-_46228023 3.61 ENSDART00000153455
si:ch211-226h7.6
chr10_+_19595009 3.50 ENSDART00000112276
zgc:173837
chr17_-_6349044 3.45 ENSDART00000081707
organic cation transporter 2
chr13_-_37180815 3.39 ENSDART00000139907
si:dkeyp-77c8.1
chr9_+_17306162 3.34 ENSDART00000075926
sciellin
chr1_+_40308077 3.34 ENSDART00000138992
von Willebrand factor A domain containing 10, tandem duplicate 2
chr16_+_26774182 3.28 ENSDART00000042895
cadherin 17, LI cadherin (liver-intestine)
chr3_-_39171968 3.26 ENSDART00000154494
si:dkeyp-57f11.2
chr18_+_54354 3.25 ENSDART00000097163
zgc:158482
chr5_-_64355227 3.18 ENSDART00000170787
family with sequence similarity 78, member Aa
chr9_-_30165621 3.18 ENSDART00000089543
ABI family, member 3 (NESH) binding protein a
chr14_+_48862987 3.14 ENSDART00000167810
zgc:154054
chr21_-_34972872 3.03 ENSDART00000023838
lipase, member Ia
chr7_-_69795488 3.02 ENSDART00000162414
ubiquitin specific peptidase 53
chr12_+_20641102 3.00 ENSDART00000152964
calcium binding and coiled-coil domain 2
chr23_-_5719453 2.99 ENSDART00000033093
ladinin
chr8_-_36412936 2.95 ENSDART00000159276
si:zfos-2070c2.3
chr1_+_24355515 2.93 ENSDART00000051763
ribosomal protein S3A
chr10_-_13116337 2.92 ENSDART00000164568
muscle, skeletal, receptor tyrosine kinase
chr8_-_3312384 2.88 ENSDART00000035965
fucosyltransferase 9b
chr21_+_33454147 2.86 ENSDART00000053208
ribosomal protein S14
chr19_+_5640504 2.84 ENSDART00000179987
alpha(1,3)fucosyltransferase gene 2
chr25_+_31405266 2.81 ENSDART00000103395
troponin T type 3a (skeletal, fast)
chr22_+_26600834 2.80 ENSDART00000157411
adenylate cyclase 9
chr21_-_11632403 2.78 ENSDART00000171708
ENSDART00000138619
ENSDART00000136308
ENSDART00000144770
calpastatin
chr15_+_36054864 2.74 ENSDART00000156697
collagen, type IV, alpha 3
chr4_-_77114795 2.70 ENSDART00000144849

chr11_-_25853212 2.68 ENSDART00000145655
transmembrane protein 51b
chr13_-_34858500 2.67 ENSDART00000184843
serine palmitoyltransferase, long chain base subunit 3
chr2_-_28396993 2.65 ENSDART00000188170

chr12_+_28749189 2.63 ENSDART00000013980
T-box 21
chr19_+_34952582 2.63 ENSDART00000147714
WNT1 inducible signaling pathway protein 1a
chr3_+_36275633 2.61 ENSDART00000185027
ENSDART00000149532
ENSDART00000102883
ENSDART00000148444
zgc:86896
chr5_-_16475374 2.58 ENSDART00000134274
ENSDART00000136004
piwi-like RNA-mediated gene silencing 2
chr4_-_11594202 2.58 ENSDART00000002682
neuroepithelial cell transforming 1
chr6_+_23057311 2.56 ENSDART00000026448
envoplakin a
chr16_-_30878521 2.55 ENSDART00000141403
DENN/MADD domain containing 3b
chr10_+_19569052 2.55 ENSDART00000058425

chr1_+_54655160 2.48 ENSDART00000190319
si:ch211-202h22.7
chr3_-_32603191 2.46 ENSDART00000150997
si:ch73-248e21.7
chr3_+_5331428 2.45 ENSDART00000156561
si:ch73-106l15.4
chr4_-_64703 2.45 ENSDART00000167851

chr3_-_53508580 2.42 ENSDART00000073978
zgc:171711
chr13_+_18533005 2.40 ENSDART00000136024
finTRIM family, member 14-like
chr3_-_60027255 2.38 ENSDART00000189252
ENSDART00000154684
RecQ helicase-like 5
chr15_+_13984879 2.36 ENSDART00000159438
zgc:162730
chr14_-_28568107 2.36 ENSDART00000042850
ENSDART00000145502
preproinsulin b
chr6_+_40794015 2.34 ENSDART00000144479
GATA binding protein 2b
chr12_-_36045283 2.34 ENSDART00000160646
G protein-coupled receptor, class C, group 5, member C
chr19_-_34995629 2.34 ENSDART00000141704
si:rp71-45k5.2
chr15_-_36727462 2.31 ENSDART00000085971
nephrosis 1, congenital, Finnish type (nephrin)
chr23_-_29003864 2.30 ENSDART00000148257
castor zinc finger 1
chr14_+_21934331 2.28 ENSDART00000123225
zgc:113229
chr11_+_21050326 2.24 ENSDART00000065984
zgc:113307
chr17_-_53359028 2.24 ENSDART00000185218

chr18_-_14274803 2.22 ENSDART00000166643
malonyl-CoA decarboxylase
chr4_+_14981854 2.22 ENSDART00000067046
cation/H+ exchanger protein 1
chr19_+_4076259 2.21 ENSDART00000160633
zgc:173581
chr21_-_41025340 2.20 ENSDART00000148231
PLAC8-like 1
chr5_-_32338866 2.17 ENSDART00000017956
ENSDART00000047670
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr3_+_5297493 2.17 ENSDART00000138596
si:ch211-150d5.3
chr3_-_5228841 2.16 ENSDART00000092373
ENSDART00000182438
myosin, heavy chain 9b, non-muscle
chr20_+_52546186 2.14 ENSDART00000110777
ENSDART00000153377
ENSDART00000153013
ENSDART00000042704
eukaryotic translation elongation factor 1 delta b (guanine nucleotide exchange protein)
chr25_-_35169303 2.13 ENSDART00000193240
anoctamin 9a
chr23_+_19790962 2.12 ENSDART00000142228
filamin A, alpha (actin binding protein 280)
chr24_-_42108655 2.12 ENSDART00000032722
phosphatidylinositol glycan anchor biosynthesis, class M
chr7_-_58776400 2.11 ENSDART00000167433
SRY (sex determining region Y)-box 17
chr2_-_2642476 2.11 ENSDART00000124032
SERPINE1 mRNA binding protein 1b
chr10_-_21542702 2.09 ENSDART00000146761
ENSDART00000134502
zgc:165539
chr12_-_44180132 2.09 ENSDART00000165998
si:ch73-329n5.1
chr23_-_270847 2.08 ENSDART00000191867
ankyrin repeat and sterile alpha motif domain containing 1Aa
chr23_-_16734009 2.07 ENSDART00000125449
si:ch211-224l10.4
chr7_+_65673885 2.06 ENSDART00000169182
parvin, alpha b
chr10_-_1961930 2.06 ENSDART00000122446
teratocarcinoma-derived growth factor 1
chr3_-_23604396 2.05 ENSDART00000078423
ATP synthase membrane subunit c locus 1
chr3_+_26345732 2.03 ENSDART00000128613
ribosomal protein S15a
chr4_-_880415 2.03 ENSDART00000149162
crystallin beta-gamma domain containing 1b
chr22_-_29242347 2.02 ENSDART00000040761
parvalbumin 7
chr23_-_45501177 2.00 ENSDART00000150103
collagen type XXIV alpha 1
chr5_-_68333081 1.98 ENSDART00000168786
linker histone H1M
chr3_+_33761549 1.95 ENSDART00000169337
immediate early response 2a
chr2_+_30379650 1.95 ENSDART00000129542
cysteine-rich secretory protein LCCL domain containing 1b
chr15_-_20916251 1.94 ENSDART00000134053
ubiquitin specific peptidase 2a
chr8_-_20243389 1.94 ENSDART00000184904
alkaline ceramidase 1
chr11_-_11575070 1.92 ENSDART00000142208
zgc:110712
chr23_+_31107685 1.89 ENSDART00000103448
T-box 18
chr13_+_23623346 1.88 ENSDART00000057619
interleukin 22 receptor, alpha 2
chr7_-_55648336 1.88 ENSDART00000147792
ENSDART00000135304
ENSDART00000131923
poly(A) binding protein, nuclear 1-like (cytoplasmic)
chr14_+_7699443 1.85 ENSDART00000123139
bromodomain containing 8
chr13_-_51846224 1.85 ENSDART00000184663

chr10_-_15849027 1.83 ENSDART00000184682
tight junction protein 2a (zona occludens 2)
chr5_+_36439405 1.83 ENSDART00000102973
ectodysplasin A
chr19_-_3741602 1.83 ENSDART00000170301
bloodthirsty-related gene family, member 22
chr7_-_51368681 1.83 ENSDART00000146385
Rho GTPase activating protein 36
chr14_+_41318881 1.82 ENSDART00000192137
XK, Kell blood group complex subunit-related, X-linked
chr5_+_51909740 1.82 ENSDART00000162541
thrombospondin 4a
chr23_-_26535875 1.80 ENSDART00000135988
si:dkey-205h13.2
chr15_-_28587490 1.80 ENSDART00000186196
slingshot protein phosphatase 2a
chr10_-_35149513 1.80 ENSDART00000063434
ENSDART00000131291
receptor-interacting serine-threonine kinase 4
chr16_+_24971717 1.79 ENSDART00000156958
formyl peptide receptor 1
chr2_-_32237916 1.78 ENSDART00000141418
family with sequence similarity 49, member Ba
chr8_+_40628926 1.77 ENSDART00000163598
dual specificity phosphatase 2
chr11_+_36683859 1.75 ENSDART00000170102
si:ch211-11c3.12
chr14_-_48103207 1.74 ENSDART00000056712
electron-transferring-flavoprotein dehydrogenase
chr5_-_16475682 1.74 ENSDART00000090695
piwi-like RNA-mediated gene silencing 2
chr11_-_6452444 1.73 ENSDART00000137879
ENSDART00000134957
ENSDART00000004483
La ribonucleoprotein domain family, member 6b
chr8_+_25569903 1.72 ENSDART00000062375
si:dkey-48j7.3
chr4_+_8638622 1.71 ENSDART00000186829
wingless-type MMTV integration site family, member 5b
chr1_-_6085750 1.70 ENSDART00000138891
si:ch1073-345a8.1
chr13_+_27232694 1.68 ENSDART00000131128
Ras and Rab interactor 2
chr2_-_14793343 1.67 ENSDART00000132264
si:ch73-366i20.1
chr2_-_58257624 1.66 ENSDART00000098940
forkhead box L2b
chr4_+_8532580 1.66 ENSDART00000162065
wingless-type MMTV integration site family, member 5b
chr14_+_35024521 1.65 ENSDART00000158634
ENSDART00000170631
early B cell factor 3a
chr22_-_17652914 1.65 ENSDART00000138483
si:ch73-243b8.4
chr22_-_17653143 1.64 ENSDART00000089171
histocompatibility (minor) HA-1 b
chr24_-_2423791 1.63 ENSDART00000190402
ras responsive element binding protein 1a
chr10_-_45029041 1.63 ENSDART00000167878
polymerase (DNA directed), mu
chr20_+_51104367 1.63 ENSDART00000073981
eukaryotic translation initiation factor 2, subunit 1 alpha b
chr23_-_20345473 1.63 ENSDART00000140935
si:rp71-17i16.6
chr3_+_12748038 1.63 ENSDART00000181174
cytochrome P450, family 2, subfamily k, polypeptide 21
chr25_+_18556588 1.62 ENSDART00000073726
caveolin 2
chr1_+_524717 1.61 ENSDART00000102421
ENSDART00000184473
mitochondrial ribosomal protein L16
chr7_+_41887429 1.61 ENSDART00000115090
glutamic pyruvate transaminase (alanine aminotransferase) 2
chr23_+_23232136 1.60 ENSDART00000126479
ENSDART00000187764
pleckstrin homology domain containing, family N member 1
chr3_-_12352793 1.60 ENSDART00000165013
presequence translocase associated motor 16
chr9_-_15362556 1.59 ENSDART00000191233
fibronectin 1a
chr16_+_5926520 1.59 ENSDART00000162229
unc-51 like kinase 4
chr21_-_3700334 1.59 ENSDART00000137844
ATPase phospholipid transporting 8B1
chr19_+_41464870 1.59 ENSDART00000102778
distal-less homeobox 6a
chr4_-_77216726 1.59 ENSDART00000099943
proteasome subunit beta 10

Network of associatons between targets according to the STRING database.

First level regulatory network of tbx5a+tbx5b

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 11.4 GO:0009957 epidermal cell fate specification(GO:0009957)
1.7 6.9 GO:0006740 NADPH regeneration(GO:0006740)
1.4 5.5 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
1.4 4.1 GO:0097264 self proteolysis(GO:0097264)
1.1 4.3 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
1.0 6.2 GO:0097101 blood vessel endothelial cell fate specification(GO:0097101)
1.0 5.9 GO:0033292 T-tubule organization(GO:0033292)
0.9 3.7 GO:0003418 plasma membrane repair(GO:0001778) chondrocyte differentiation involved in endochondral bone morphogenesis(GO:0003413) growth plate cartilage chondrocyte differentiation(GO:0003418)
0.8 5.4 GO:0060017 parathyroid gland development(GO:0060017)
0.7 2.1 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
0.7 2.1 GO:0090008 hypoblast development(GO:0090008)
0.7 3.4 GO:1904105 regulation of Wnt signaling pathway, calcium modulating pathway(GO:0008591) positive regulation of convergent extension involved in gastrulation(GO:1904105)
0.7 10.7 GO:0016203 muscle attachment(GO:0016203)
0.6 3.8 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.6 1.7 GO:0048496 maintenance of organ identity(GO:0048496)
0.5 4.1 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.5 1.6 GO:0005997 xylulose metabolic process(GO:0005997)
0.5 5.6 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.5 3.7 GO:0031179 peptide modification(GO:0031179)
0.4 2.2 GO:2001293 malonyl-CoA metabolic process(GO:2001293)
0.4 3.9 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.4 4.6 GO:0046512 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.4 2.8 GO:0097341 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
0.4 1.2 GO:0003156 regulation of organ formation(GO:0003156)
0.4 1.5 GO:0036462 TRAIL-activated apoptotic signaling pathway(GO:0036462)
0.4 2.9 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.4 2.2 GO:0070650 actin filament bundle distribution(GO:0070650)
0.4 1.4 GO:0006266 DNA ligation(GO:0006266) DNA ligation involved in DNA repair(GO:0051103)
0.4 1.1 GO:0043504 mitochondrial DNA repair(GO:0043504)
0.3 1.4 GO:0070199 establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169)
0.3 2.4 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.3 4.9 GO:0061055 myotome development(GO:0061055)
0.3 1.9 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.3 4.1 GO:0014036 neural crest cell fate commitment(GO:0014034) neural crest cell fate specification(GO:0014036)
0.3 6.8 GO:0031033 myosin filament organization(GO:0031033)
0.3 1.8 GO:0002283 neutrophil activation involved in immune response(GO:0002283)
0.3 4.7 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.3 4.2 GO:0060325 face morphogenesis(GO:0060325)
0.3 0.8 GO:0098581 detection of biotic stimulus(GO:0009595) detection of bacterium(GO:0016045) detection of other organism(GO:0098543) detection of external biotic stimulus(GO:0098581)
0.3 2.2 GO:1905207 regulation of cardiocyte differentiation(GO:1905207) regulation of cardiac muscle cell differentiation(GO:2000725)
0.3 1.3 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.3 1.3 GO:0071423 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) malate transmembrane transport(GO:0071423)
0.3 1.6 GO:0045852 pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.3 1.5 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.2 1.2 GO:0006031 chitin biosynthetic process(GO:0006031) glucosamine-containing compound biosynthetic process(GO:1901073)
0.2 1.6 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.2 1.6 GO:0006953 cardioblast migration to the midline involved in heart rudiment formation(GO:0003319) acute-phase response(GO:0006953) establishment of epithelial cell apical/basal polarity(GO:0045198)
0.2 1.1 GO:0035678 neuromast hair cell morphogenesis(GO:0035678)
0.2 4.4 GO:0007271 synaptic transmission, cholinergic(GO:0007271)
0.2 1.3 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.2 2.6 GO:0032925 regulation of activin receptor signaling pathway(GO:0032925)
0.2 0.6 GO:0098725 somatic stem cell population maintenance(GO:0035019) symmetric cell division(GO:0098725)
0.2 2.1 GO:0061588 calcium activated phospholipid scrambling(GO:0061588)
0.2 0.6 GO:0015695 organic cation transport(GO:0015695)
0.2 0.6 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.2 0.6 GO:1901533 negative regulation of hematopoietic progenitor cell differentiation(GO:1901533)
0.2 0.8 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.2 1.0 GO:0072672 neutrophil extravasation(GO:0072672) regulation of neutrophil extravasation(GO:2000389) positive regulation of neutrophil extravasation(GO:2000391)
0.2 0.7 GO:0016038 absorption of visible light(GO:0016038)
0.2 0.5 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
0.2 3.0 GO:0019433 triglyceride catabolic process(GO:0019433)
0.2 1.9 GO:0050909 sensory perception of taste(GO:0050909)
0.2 5.2 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.2 0.9 GO:0034695 response to prostaglandin E(GO:0034695) cellular response to prostaglandin E stimulus(GO:0071380)
0.2 0.5 GO:0030238 female sex determination(GO:0030237) male sex determination(GO:0030238)
0.2 0.7 GO:2000392 lamellipodium morphogenesis(GO:0072673) regulation of lamellipodium morphogenesis(GO:2000392)
0.2 2.6 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.2 1.0 GO:0071800 podosome assembly(GO:0071800)
0.2 0.7 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.2 3.0 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.2 1.1 GO:1904030 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.2 0.9 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.2 1.4 GO:0060004 reflex(GO:0060004) vestibular reflex(GO:0060005)
0.2 0.6 GO:0070291 N-acylethanolamine metabolic process(GO:0070291)
0.2 1.8 GO:0051121 lipoxygenase pathway(GO:0019372) linoleic acid metabolic process(GO:0043651) hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.1 1.0 GO:0032469 endoplasmic reticulum calcium ion homeostasis(GO:0032469)
0.1 2.7 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 1.0 GO:1901224 positive regulation of NIK/NF-kappaB signaling(GO:1901224)
0.1 6.4 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.1 0.7 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.1 2.5 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.1 1.3 GO:0060612 adipose tissue development(GO:0060612)
0.1 2.1 GO:0036065 fucosylation(GO:0036065)
0.1 0.4 GO:0001774 microglial cell activation(GO:0001774)
0.1 4.2 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.1 2.3 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.1 1.8 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 2.9 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 1.1 GO:0071539 protein localization to centrosome(GO:0071539)
0.1 2.8 GO:0006942 regulation of striated muscle contraction(GO:0006942)
0.1 2.1 GO:0035141 medial fin morphogenesis(GO:0035141)
0.1 2.0 GO:0016584 nucleosome positioning(GO:0016584)
0.1 4.2 GO:0003009 skeletal muscle contraction(GO:0003009)
0.1 2.4 GO:0015701 bicarbonate transport(GO:0015701)
0.1 3.9 GO:0043113 receptor clustering(GO:0043113)
0.1 0.6 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 0.5 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.1 1.6 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 0.4 GO:0055024 regulation of cardiac muscle tissue development(GO:0055024)
0.1 0.9 GO:0003160 endocardium morphogenesis(GO:0003160)
0.1 1.5 GO:0030216 keratinocyte differentiation(GO:0030216)
0.1 1.0 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.1 2.1 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 2.8 GO:0032543 mitochondrial translation(GO:0032543)
0.1 1.1 GO:0010092 specification of organ identity(GO:0010092)
0.1 2.0 GO:0042476 odontogenesis(GO:0042476)
0.1 1.8 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 0.6 GO:0035627 ceramide transport(GO:0035627)
0.1 1.2 GO:0051127 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1 2.0 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 1.8 GO:0034112 positive regulation of homotypic cell-cell adhesion(GO:0034112) positive regulation of T cell activation(GO:0050870) positive regulation of leukocyte cell-cell adhesion(GO:1903039)
0.1 2.4 GO:0044243 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.1 3.9 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.1 2.6 GO:0003094 glomerular filtration(GO:0003094)
0.1 3.6 GO:0030282 bone mineralization(GO:0030282)
0.1 2.1 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.1 0.8 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.1 1.6 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1 1.4 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.1 0.5 GO:0036372 opsin transport(GO:0036372)
0.1 0.8 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.1 0.3 GO:0042148 strand invasion(GO:0042148)
0.1 0.3 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.1 0.6 GO:0042664 negative regulation of endodermal cell fate specification(GO:0042664) negative regulation of endodermal cell differentiation(GO:1903225)
0.1 1.2 GO:0060030 dorsal convergence(GO:0060030)
0.1 0.3 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.2 GO:0050881 multicellular organismal movement(GO:0050879) musculoskeletal movement(GO:0050881)
0.1 1.6 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.1 2.6 GO:0045104 intermediate filament-based process(GO:0045103) intermediate filament cytoskeleton organization(GO:0045104)
0.1 0.5 GO:0070874 negative regulation of peptidyl-serine phosphorylation(GO:0033137) negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.1 1.4 GO:1902622 regulation of neutrophil migration(GO:1902622)
0.1 1.1 GO:0008406 gonad development(GO:0008406) regulation of meiotic cell cycle(GO:0051445)
0.1 1.2 GO:0050935 iridophore differentiation(GO:0050935)
0.1 0.5 GO:0098787 mRNA cleavage involved in mRNA processing(GO:0098787) pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.1 1.4 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.1 0.2 GO:0043011 myeloid dendritic cell activation(GO:0001773) myeloid dendritic cell differentiation(GO:0043011)
0.1 1.7 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.1 0.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 0.3 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.1 0.6 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1 11.6 GO:0030198 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.1 1.3 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 1.6 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.3 GO:2000463 postsynaptic density assembly(GO:0097107) modulation of excitatory postsynaptic potential(GO:0098815) positive regulation of excitatory postsynaptic potential(GO:2000463)
0.0 0.9 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.0 4.0 GO:0070121 Kupffer's vesicle development(GO:0070121)
0.0 0.5 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.2 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0 0.3 GO:0010595 positive regulation of endothelial cell migration(GO:0010595)
0.0 1.1 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.2 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.0 1.0 GO:0002377 immunoglobulin production(GO:0002377)
0.0 0.8 GO:0001757 somite specification(GO:0001757)
0.0 0.3 GO:0031048 chromatin silencing by small RNA(GO:0031048)
0.0 0.2 GO:0061157 RNA destabilization(GO:0050779) mRNA destabilization(GO:0061157)
0.0 0.5 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.0 0.9 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
0.0 1.8 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 0.3 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.0 1.5 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.0 0.1 GO:0070734 histone H3-K27 methylation(GO:0070734)
0.0 2.3 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 1.5 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 0.9 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.4 GO:0008272 sulfate transport(GO:0008272)
0.0 2.6 GO:0006006 glucose metabolic process(GO:0006006)
0.0 0.2 GO:0050975 sensory perception of touch(GO:0050975)
0.0 3.8 GO:0045055 regulated exocytosis(GO:0045055)
0.0 0.6 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 0.5 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.0 0.7 GO:0019229 regulation of vasoconstriction(GO:0019229)
0.0 0.1 GO:0070197 telomere localization(GO:0034397) telomere tethering at nuclear periphery(GO:0034398) meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic telomere clustering(GO:0045141) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220) chromosome attachment to the nuclear envelope(GO:0097240)
0.0 0.2 GO:0002285 lymphocyte activation involved in immune response(GO:0002285) T cell activation involved in immune response(GO:0002286) positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.0 0.4 GO:0001706 endoderm formation(GO:0001706)
0.0 0.1 GO:1904031 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0 0.7 GO:0007568 aging(GO:0007568)
0.0 0.9 GO:0001878 response to yeast(GO:0001878)
0.0 2.0 GO:0007030 Golgi organization(GO:0007030)
0.0 2.3 GO:0001708 cell fate specification(GO:0001708)
0.0 1.1 GO:0048484 enteric nervous system development(GO:0048484)
0.0 1.8 GO:0031101 fin regeneration(GO:0031101)
0.0 4.4 GO:0007601 visual perception(GO:0007601)
0.0 0.4 GO:0032438 melanosome organization(GO:0032438)
0.0 0.8 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.0 0.4 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 2.5 GO:0048793 pronephros development(GO:0048793)
0.0 0.2 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.3 GO:1902307 positive regulation of sodium ion transport(GO:0010765) positive regulation of potassium ion transport(GO:0043268) positive regulation of potassium ion transmembrane transport(GO:1901381) positive regulation of sodium ion transmembrane transport(GO:1902307) regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288) positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.0 0.9 GO:0043648 dicarboxylic acid metabolic process(GO:0043648)
0.0 1.3 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 1.5 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 0.5 GO:0030901 midbrain development(GO:0030901)
0.0 0.3 GO:0048168 regulation of neuronal synaptic plasticity(GO:0048168)
0.0 0.3 GO:0043652 engulfment of apoptotic cell(GO:0043652)
0.0 1.3 GO:0006413 translational initiation(GO:0006413)
0.0 0.1 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.0 1.2 GO:0008544 epidermis development(GO:0008544)
0.0 2.9 GO:0016197 endosomal transport(GO:0016197)
0.0 0.2 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0 0.2 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.0 0.3 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.3 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.0 7.4 GO:0016567 protein ubiquitination(GO:0016567)
0.0 0.3 GO:0006099 tricarboxylic acid cycle(GO:0006099)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 10.9 GO:0045095 keratin filament(GO:0045095)
0.9 4.3 GO:1990923 PET complex(GO:1990923)
0.6 1.9 GO:0005592 collagen type XI trimer(GO:0005592)
0.5 1.6 GO:0043614 multi-eIF complex(GO:0043614)
0.5 1.4 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.4 2.1 GO:0031501 mannosyltransferase complex(GO:0031501)
0.4 2.3 GO:0070062 extracellular exosome(GO:0070062)
0.4 2.2 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.4 4.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.3 1.4 GO:0044326 dendritic spine neck(GO:0044326) dendritic filopodium(GO:1902737)
0.3 0.9 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.3 2.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.3 0.9 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.3 1.1 GO:0044214 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.3 3.8 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.3 0.8 GO:0000941 condensed nuclear chromosome inner kinetochore(GO:0000941)
0.3 2.7 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.2 4.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.2 1.6 GO:0005614 interstitial matrix(GO:0005614)
0.2 2.1 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.2 5.4 GO:0031672 A band(GO:0031672)
0.2 7.5 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.2 8.0 GO:0031941 filamentous actin(GO:0031941)
0.2 0.7 GO:0032433 filopodium tip(GO:0032433)
0.2 2.3 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.2 7.0 GO:0005861 troponin complex(GO:0005861)
0.2 20.8 GO:0030055 cell-substrate junction(GO:0030055)
0.2 7.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 1.2 GO:0030428 cell septum(GO:0030428)
0.1 11.9 GO:0005882 intermediate filament(GO:0005882)
0.1 1.5 GO:0030904 retromer complex(GO:0030904)
0.1 2.1 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 1.4 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 1.4 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 7.0 GO:0030018 Z disc(GO:0030018)
0.1 0.3 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 0.9 GO:0045240 dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.1 1.6 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 0.6 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.1 0.9 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 1.0 GO:0002102 podosome(GO:0002102)
0.1 1.2 GO:0031209 SCAR complex(GO:0031209)
0.1 26.1 GO:0031012 extracellular matrix(GO:0031012)
0.1 0.2 GO:0031310 integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
0.1 3.3 GO:0016342 catenin complex(GO:0016342)
0.1 0.2 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 0.5 GO:0071797 LUBAC complex(GO:0071797)
0.1 0.9 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.1 1.6 GO:0005839 proteasome core complex(GO:0005839)
0.1 0.4 GO:0036156 inner dynein arm(GO:0036156)
0.0 2.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 2.6 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.2 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.0 0.6 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.1 GO:0043186 P granule(GO:0043186)
0.0 4.7 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 1.7 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.5 GO:0036038 MKS complex(GO:0036038)
0.0 0.5 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.6 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 3.4 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 0.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 2.7 GO:0000786 nucleosome(GO:0000786)
0.0 2.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.5 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.0 1.8 GO:0005814 centriole(GO:0005814)
0.0 1.2 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 1.9 GO:0005911 cell-cell junction(GO:0005911)
0.0 20.6 GO:0005615 extracellular space(GO:0005615)
0.0 0.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.1 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.4 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.3 GO:0030667 secretory granule membrane(GO:0030667)
0.0 1.3 GO:0036464 cytoplasmic ribonucleoprotein granule(GO:0036464)
0.0 0.3 GO:0000421 autophagosome membrane(GO:0000421)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 6.9 GO:0016652 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.6 1.7 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.6 2.2 GO:0051139 calcium:proton antiporter activity(GO:0015369) metal ion:proton antiporter activity(GO:0051139)
0.5 4.3 GO:0034584 piRNA binding(GO:0034584)
0.5 1.6 GO:1901612 cardiolipin binding(GO:1901612)
0.5 1.6 GO:0070051 fibrinogen binding(GO:0070051)
0.4 2.6 GO:0019215 intermediate filament binding(GO:0019215)
0.4 3.7 GO:0000048 peptidyltransferase activity(GO:0000048) glutathione hydrolase activity(GO:0036374)
0.4 2.9 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.4 6.0 GO:0051879 Hsp90 protein binding(GO:0051879)
0.4 2.8 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.4 2.7 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.4 1.4 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.4 3.9 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.3 3.0 GO:0038064 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.3 1.9 GO:0017040 ceramidase activity(GO:0017040)
0.3 5.6 GO:0048185 activin binding(GO:0048185)
0.3 0.8 GO:0016019 peptidoglycan receptor activity(GO:0016019)
0.3 3.0 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.3 0.8 GO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity(GO:0000703)
0.3 2.1 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.3 2.4 GO:0009378 four-way junction helicase activity(GO:0009378)
0.3 1.3 GO:0015140 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140)
0.3 2.8 GO:0031013 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.2 0.7 GO:0005502 11-cis retinal binding(GO:0005502)
0.2 1.2 GO:0098639 C-X3-C chemokine binding(GO:0019960) protein binding involved in cell-matrix adhesion(GO:0098634) collagen binding involved in cell-matrix adhesion(GO:0098639)
0.2 2.8 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.2 1.6 GO:0004051 arachidonate 5-lipoxygenase activity(GO:0004051)
0.2 3.3 GO:0005123 death receptor binding(GO:0005123)
0.2 4.3 GO:0004875 complement receptor activity(GO:0004875)
0.2 3.0 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.2 1.8 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.2 1.6 GO:0001948 glycoprotein binding(GO:0001948) proteoglycan binding(GO:0043394)
0.2 5.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 1.3 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.2 0.5 GO:0009041 uridylate kinase activity(GO:0009041)
0.2 0.9 GO:0008131 primary amine oxidase activity(GO:0008131)
0.2 1.2 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.2 0.7 GO:0004945 angiotensin type I receptor activity(GO:0001596) angiotensin type II receptor activity(GO:0004945)
0.2 1.1 GO:0004974 leukotriene receptor activity(GO:0004974)
0.2 4.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 1.2 GO:0004100 chitin synthase activity(GO:0004100)
0.1 1.9 GO:0070697 activin receptor binding(GO:0070697)
0.1 1.1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 1.1 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 4.2 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.1 1.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 1.8 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.1 4.4 GO:0015106 bicarbonate transmembrane transporter activity(GO:0015106)
0.1 1.4 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.1 0.9 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.1 0.9 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 2.7 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 2.3 GO:0051393 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.1 1.0 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.1 0.6 GO:0035620 ceramide transporter activity(GO:0035620) ceramide 1-phosphate binding(GO:1902387) ceramide 1-phosphate transporter activity(GO:1902388)
0.1 0.4 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 0.9 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 2.0 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 0.3 GO:0000150 recombinase activity(GO:0000150)
0.1 0.9 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.1 4.9 GO:0019209 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.1 2.0 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 1.0 GO:0008422 beta-glucosidase activity(GO:0008422)
0.1 1.6 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.5 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.1 0.7 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.1 10.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 3.7 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 0.6 GO:0015057 thrombin receptor activity(GO:0015057)
0.1 4.2 GO:0004521 endoribonuclease activity(GO:0004521)
0.1 14.8 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.1 1.9 GO:0004016 adenylate cyclase activity(GO:0004016)
0.1 0.3 GO:0035197 siRNA binding(GO:0035197)
0.1 4.7 GO:0003823 antigen binding(GO:0003823)
0.1 2.8 GO:0019843 rRNA binding(GO:0019843)
0.1 0.9 GO:0070628 proteasome binding(GO:0070628)
0.1 1.0 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.1 0.2 GO:0008459 chondroitin 6-sulfotransferase activity(GO:0008459)
0.1 0.6 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.1 1.5 GO:0005112 Notch binding(GO:0005112)
0.1 4.2 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.1 0.7 GO:0001968 fibronectin binding(GO:0001968)
0.1 0.6 GO:0015101 organic cation transmembrane transporter activity(GO:0015101)
0.0 1.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.5 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.0 0.6 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.3 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 1.3 GO:0022842 leak channel activity(GO:0022840) potassium ion leak channel activity(GO:0022841) narrow pore channel activity(GO:0022842)
0.0 0.5 GO:0005042 netrin receptor activity(GO:0005042)
0.0 1.4 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.2 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 1.4 GO:0099604 ligand-gated calcium channel activity(GO:0099604)
0.0 1.1 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 1.3 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 1.4 GO:0035064 methylated histone binding(GO:0035064)
0.0 1.5 GO:0005109 frizzled binding(GO:0005109)
0.0 5.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.7 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 3.3 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 5.8 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 1.6 GO:0043022 ribosome binding(GO:0043022)
0.0 0.5 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.6 GO:0030515 snoRNA binding(GO:0030515)
0.0 1.1 GO:0030145 manganese ion binding(GO:0030145)
0.0 0.5 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.5 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 2.2 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 2.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.5 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 0.4 GO:0005223 intracellular ligand-gated ion channel activity(GO:0005217) intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 3.3 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 4.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.4 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 4.1 GO:0030414 peptidase inhibitor activity(GO:0030414)
0.0 0.9 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 8.6 GO:0005198 structural molecule activity(GO:0005198)
0.0 0.4 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.9 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.4 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 0.6 GO:0008378 galactosyltransferase activity(GO:0008378)
0.0 8.8 GO:0003712 transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712)
0.0 34.3 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 0.2 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 2.3 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 1.5 GO:0003724 RNA helicase activity(GO:0003724)
0.0 1.2 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.3 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.3 GO:0019869 chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870)
0.0 8.7 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.3 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.1 GO:0045309 protein phosphorylated amino acid binding(GO:0045309) phosphoprotein binding(GO:0051219)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.3 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.3 3.9 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.3 0.6 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.2 8.9 NABA COLLAGENS Genes encoding collagen proteins
0.2 1.0 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.2 3.9 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 2.6 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 7.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 3.2 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 3.2 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 1.6 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.1 2.1 PID GLYPICAN 1PATHWAY Glypican 1 network
0.1 3.3 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.1 2.7 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.1 2.1 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 1.8 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 0.3 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.1 1.3 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.1 0.9 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 1.5 PID RAS PATHWAY Regulation of Ras family activation
0.1 1.3 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 0.9 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 1.5 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.1 2.3 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.1 1.7 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 2.2 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 1.2 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.1 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 6.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 6.1 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.5 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 1.7 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.3 PID FGF PATHWAY FGF signaling pathway
0.0 0.7 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 2.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.3 ST GA13 PATHWAY G alpha 13 Pathway
0.0 0.4 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.6 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.2 PID SHP2 PATHWAY SHP2 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.3 2.7 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.2 1.4 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.2 0.6 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.2 2.1 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.2 2.8 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.2 1.5 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.2 8.9 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.2 8.8 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 1.6 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 0.7 REACTOME OPSINS Genes involved in Opsins
0.1 2.6 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 2.1 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 1.3 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.1 3.0 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.1 0.2 REACTOME FRS2 MEDIATED CASCADE Genes involved in FRS2-mediated cascade
0.1 0.6 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 0.7 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 3.9 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.1 0.8 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.1 0.9 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 3.4 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 1.9 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 0.5 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 1.0 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 2.5 REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.1 0.5 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.1 3.9 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.4 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 1.2 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.1 1.0 REACTOME FGFR LIGAND BINDING AND ACTIVATION Genes involved in FGFR ligand binding and activation
0.0 0.6 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.8 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.9 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.3 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.4 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 2.6 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 2.4 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.7 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.4 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.5 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.3 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.3 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.4 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.3 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.7 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides