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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for tfap2a+tfap2c

Z-value: 0.51

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Transcription factors associated with tfap2a+tfap2c

Gene Symbol Gene ID Gene Info
tfap2c
ENSDARG00000040606 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
tfap2a
ENSDARG00000059279 transcription factor AP-2 alpha

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tfap2adr11_v1_chr24_-_8730913_87310390.711.1e-15Click!
tfap2cdr11_v1_chr6_+_56147812_561478120.534.4e-08Click!

Activity profile of tfap2a+tfap2c motif

Sorted Z-values of tfap2a+tfap2c motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_16098531 7.43 ENSDART00000080377
aldoca
aldolase C, fructose-bisphosphate, a
chr19_-_9472893 7.42 ENSDART00000045565
ENSDART00000137505
vamp1
vesicle-associated membrane protein 1
chr15_-_44512461 5.95 ENSDART00000155456
gria4a
glutamate receptor, ionotropic, AMPA 4a
chr23_+_37323962 3.77 ENSDART00000102881
fam43b
family with sequence similarity 43, member B
chr2_+_27010439 3.09 ENSDART00000030547
cdh7a
cadherin 7a
chr24_-_6898302 2.99 ENSDART00000158646
dpp6a
dipeptidyl-peptidase 6a
chr8_-_13211527 2.73 ENSDART00000090541
si:ch73-61d6.3
si:ch73-61d6.3
chr16_-_29458806 2.69 ENSDART00000047931
lingo4b
leucine rich repeat and Ig domain containing 4b
chr12_-_4781801 2.58 ENSDART00000167490
ENSDART00000121718
mapta
microtubule-associated protein tau a
chr8_-_13210959 2.58 ENSDART00000142224
si:ch73-61d6.3
si:ch73-61d6.3
chr10_-_8032885 2.56 ENSDART00000188619
atp6v0a2a
ATPase H+ transporting V0 subunit a2a
chr6_-_10320676 2.50 ENSDART00000151247
scn1lab
sodium channel, voltage-gated, type I like, alpha b
chr10_+_21793670 2.47 ENSDART00000168918
pcdh1gc6
protocadherin 1 gamma c 6
chr1_-_45888608 2.34 ENSDART00000139219
pnpla6
patatin-like phospholipase domain containing 6
chr3_-_54607166 2.27 ENSDART00000021977
dnmt1
DNA (cytosine-5-)-methyltransferase 1
chr11_+_30253968 2.23 ENSDART00000157272
ENSDART00000003475
ppef1
protein phosphatase, EF-hand calcium binding domain 1
chr16_+_26601364 2.14 ENSDART00000087537
epb41l4b
erythrocyte membrane protein band 4.1 like 4B
chr5_+_61799629 2.11 ENSDART00000113508
hnrnpul1l
heterogeneous nuclear ribonucleoprotein U-like 1 like
chr23_+_2760573 2.11 ENSDART00000129719
top1
DNA topoisomerase I
chr10_+_21797276 2.07 ENSDART00000169105
pcdh1g29
protocadherin 1 gamma 29
chr21_-_21089781 2.04 ENSDART00000144361
ank1b
ankyrin 1, erythrocytic b
chr3_+_36160979 2.03 ENSDART00000038525
si:ch211-234h8.7
si:ch211-234h8.7
chr9_+_32358514 1.88 ENSDART00000144608
plcl1
phospholipase C like 1
chr5_-_37933983 1.84 ENSDART00000185364
scn4bb
sodium channel, voltage-gated, type IV, beta b
chr15_+_44929497 1.75 ENSDART00000111373
pdgfd
platelet derived growth factor d
chr14_+_29609245 1.59 ENSDART00000043058
TENM2
si:dkey-34l15.2
chr18_+_34181655 1.51 ENSDART00000130831
ENSDART00000109535
gmps
guanine monophosphate synthase
chr16_-_46393154 1.48 ENSDART00000132154
si:ch73-59c19.1
si:ch73-59c19.1
chr2_+_28995776 1.45 ENSDART00000138733
cdh12a
cadherin 12, type 2a (N-cadherin 2)
chr7_-_23563092 1.32 ENSDART00000132275
gpr185b
G protein-coupled receptor 185 b
chr7_+_39011852 1.26 ENSDART00000093009
dgkza
diacylglycerol kinase, zeta a
chr1_+_49878000 1.25 ENSDART00000047876
lef1
lymphoid enhancer-binding factor 1
chr5_+_21100356 1.23 ENSDART00000051586
hs3st1l2
heparan sulfate (glucosamine) 3-O-sulfotransferase 1-like 2
chr3_-_26805455 1.22 ENSDART00000180648
pigq
phosphatidylinositol glycan anchor biosynthesis, class Q
chr19_-_30510930 1.13 ENSDART00000088760
ENSDART00000181043
bag6l
BCL2 associated athanogene 6, like
chr8_+_48942470 1.13 ENSDART00000005464
ENSDART00000132035
rer1
retention in endoplasmic reticulum sorting receptor 1
chr2_+_43750899 1.09 ENSDART00000135836
arhgap12a
Rho GTPase activating protein 12a
chr8_+_48943009 1.09 ENSDART00000180763
rer1
retention in endoplasmic reticulum sorting receptor 1
chr8_-_11004726 1.06 ENSDART00000192594
ENSDART00000020116
trim33
tripartite motif containing 33
chr14_-_572742 0.98 ENSDART00000168951
fgf2
fibroblast growth factor 2
chr8_-_26792912 0.97 ENSDART00000139787
kazna
kazrin, periplakin interacting protein a
chr19_+_10799929 0.91 ENSDART00000159152
lipea
lipase, hormone-sensitive a
chr10_-_36927594 0.90 ENSDART00000162046
sez6a
seizure related 6 homolog a
chr1_+_26467071 0.87 ENSDART00000112329
ENSDART00000159318
ENSDART00000193833
ENSDART00000011809
uso1
USO1 vesicle transport factor
chr15_-_24960730 0.86 ENSDART00000109990
ENSDART00000186706
abhd15a
abhydrolase domain containing 15a
chr11_+_31323746 0.85 ENSDART00000180220
ENSDART00000189937
sipa1l2
signal-induced proliferation-associated 1 like 2
chr5_+_63302660 0.84 ENSDART00000142131
si:ch73-376l24.2
si:ch73-376l24.2
chr15_-_40267485 0.70 ENSDART00000152253
kcnj13
potassium inwardly-rectifying channel, subfamily J, member 13
chr11_+_14333441 0.67 ENSDART00000171969
ptbp1b
polypyrimidine tract binding protein 1b
chr24_+_31374324 0.65 ENSDART00000172335
ENSDART00000163162
cpne3
copine III
chr11_-_26180714 0.64 ENSDART00000173597
kaznb
kazrin, periplakin interacting protein b
chr11_+_14321113 0.63 ENSDART00000039822
ENSDART00000137347
ENSDART00000132997
ptbp1b
polypyrimidine tract binding protein 1b
chr5_+_25736979 0.63 ENSDART00000175959
abhd17b
abhydrolase domain containing 17B
chr22_-_20105969 0.57 ENSDART00000088687
rxfp3.2b
relaxin/insulin-like family peptide receptor 3.2b
chr1_+_58990121 0.56 ENSDART00000171654
CABZ01083166.1

chr16_+_26846495 0.54 ENSDART00000078124
trim35-29
tripartite motif containing 35-29
chr23_-_9965148 0.54 ENSDART00000137308
plxnb1a
plexin b1a
chr2_-_43635777 0.51 ENSDART00000148633
itgb1b.1
integrin, beta 1b.1
chr2_+_11205795 0.48 ENSDART00000019078
lhx8a
LIM homeobox 8a
chr3_+_34846201 0.45 ENSDART00000055263
itga3a
integrin, alpha 3a
chr22_+_30839702 0.43 ENSDART00000139849
ENSDART00000135775
si:dkey-49n23.3
si:dkey-49n23.3
chr3_-_26244256 0.43 ENSDART00000103741
ppp4ca
protein phosphatase 4, catalytic subunit a
chr1_-_25486471 0.40 ENSDART00000134200
ENSDART00000141892
ENSDART00000102501
arfip1
ADP-ribosylation factor interacting protein 1 (arfaptin 1)
chr20_-_20312789 0.38 ENSDART00000114779
si:ch211-212g7.6
si:ch211-212g7.6
chr21_-_45186431 0.33 ENSDART00000193449
si:ch73-269m14.2
si:ch73-269m14.2
chr16_-_5143124 0.31 ENSDART00000131876
ENSDART00000060630
ttk
ttk protein kinase
chr10_+_5135842 0.31 ENSDART00000132627
ENSDART00000162434
zgc:113274
zgc:113274
chr5_-_41049690 0.29 ENSDART00000174936
ENSDART00000135030
pdzd2
PDZ domain containing 2
chr25_-_20378721 0.25 ENSDART00000181707
kctd15a
potassium channel tetramerization domain containing 15a
chr10_-_5135788 0.22 ENSDART00000108587
ENSDART00000138537
sec31a
SEC31 homolog A, COPII coat complex component
chr25_+_36405021 0.16 ENSDART00000152801
ankrd27
ankyrin repeat domain 27 (VPS9 domain)
chr14_-_45464112 0.15 ENSDART00000173209
ehd1a
EH-domain containing 1a
chr1_+_27977297 0.09 ENSDART00000180692
ENSDART00000166819
sugt1
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
chr24_-_21903588 0.07 ENSDART00000180991
spata13
spermatogenesis associated 13
chr19_-_5369486 0.05 ENSDART00000105004
krt17
keratin 17
chr17_-_15149192 0.04 ENSDART00000180511
ENSDART00000103405
gch1
GTP cyclohydrolase 1
chr3_-_35865040 0.04 ENSDART00000102952
suz12a
SUZ12 polycomb repressive complex 2a subunit
chr15_+_618081 0.01 ENSDART00000181518
si:ch211-210b2.1
si:ch211-210b2.1
chr1_+_42225060 0.01 ENSDART00000138740
ENSDART00000101306
ctnna2
catenin (cadherin-associated protein), alpha 2

Network of associatons between targets according to the STRING database.

First level regulatory network of tfap2a+tfap2c

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.5 7.4 GO:0035493 SNARE complex assembly(GO:0035493)
0.5 2.3 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.3 2.2 GO:0006621 protein retention in ER lumen(GO:0006621)
0.3 7.4 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.2 1.2 GO:0060784 regulation of cell proliferation involved in tissue homeostasis(GO:0060784)
0.2 0.9 GO:0048211 Golgi vesicle docking(GO:0048211)
0.2 1.9 GO:0032228 regulation of synaptic transmission, GABAergic(GO:0032228)
0.2 1.8 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.2 2.6 GO:0007035 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.2 0.7 GO:0051876 pigment granule dispersal(GO:0051876)
0.2 2.3 GO:0046470 phosphatidylcholine metabolic process(GO:0046470)
0.2 1.5 GO:0006177 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.1 3.1 GO:0060034 notochord cell differentiation(GO:0060034)
0.1 1.1 GO:0048569 post-embryonic organ development(GO:0048569)
0.1 2.1 GO:0030323 respiratory tube development(GO:0030323) lung development(GO:0030324)
0.1 2.1 GO:0006265 DNA topological change(GO:0006265)
0.1 5.3 GO:0043297 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.1 0.3 GO:0044785 meiotic cell cycle phase transition(GO:0044771) metaphase/anaphase transition of meiotic cell cycle(GO:0044785) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994) regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902102) negative regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902103) regulation of meiotic chromosome separation(GO:1905132) negative regulation of meiotic chromosome separation(GO:1905133)
0.1 3.0 GO:1901379 regulation of potassium ion transmembrane transport(GO:1901379)
0.1 0.8 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.1 1.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1 0.9 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.6 GO:0002084 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.0 1.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 2.2 GO:0050906 detection of stimulus involved in sensory perception(GO:0050906)
0.0 1.2 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.4 GO:0006670 sphingosine metabolic process(GO:0006670)
0.0 0.5 GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.0 2.0 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 2.1 GO:0009615 response to virus(GO:0009615)
0.0 4.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.2 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 0.4 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.0 0.4 GO:0048264 determination of ventral identity(GO:0048264)
0.0 0.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 2.2 GO:0072659 protein localization to plasma membrane(GO:0072659) protein localization to cell periphery(GO:1990778)
0.0 0.6 GO:0038127 ERBB signaling pathway(GO:0038127)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.6 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.2 1.2 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.2 1.1 GO:0071818 BAT3 complex(GO:0071818)
0.1 5.9 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 2.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 4.5 GO:0016342 catenin complex(GO:0016342)
0.1 7.4 GO:0031201 SNARE complex(GO:0031201)
0.1 1.2 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 5.3 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 1.1 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 2.5 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 2.2 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 0.5 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.9 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 1.0 GO:0098636 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 0.4 GO:0032588 trans-Golgi network membrane(GO:0032588)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 7.4 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.4 5.9 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.2 0.9 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.2 1.8 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.2 7.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.2 1.2 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.2 2.3 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.2 2.6 GO:0051117 ATPase binding(GO:0051117)
0.2 2.0 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.2 3.0 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.2 2.1 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.2 2.0 GO:0030507 spectrin binding(GO:0030507)
0.1 1.2 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 0.9 GO:0034338 short-chain carboxylesterase activity(GO:0034338)
0.1 2.3 GO:0004622 lysophospholipase activity(GO:0004622)
0.1 2.7 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 1.5 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.1 2.5 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.1 0.5 GO:0098639 C-X3-C chemokine binding(GO:0019960) protein binding involved in cell-matrix adhesion(GO:0098634) collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.4 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.1 1.9 GO:0050811 GABA receptor binding(GO:0050811)
0.1 1.1 GO:0070628 proteasome binding(GO:0070628)
0.1 1.2 GO:0008301 DNA binding, bending(GO:0008301)
0.1 2.2 GO:0030145 manganese ion binding(GO:0030145)
0.1 1.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 4.6 GO:0045296 cadherin binding(GO:0045296)
0.0 0.4 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.6 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 1.0 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.6 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.7 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.5 GO:0017154 semaphorin receptor activity(GO:0017154)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 1.0 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 2.1 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.9 PID ARF 3PATHWAY Arf1 pathway
0.0 2.3 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 1.2 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.4 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.2 1.0 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.1 1.5 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 1.2 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 1.1 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 1.8 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
0.0 0.2 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC