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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for thrb

Z-value: 0.42

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Transcription factors associated with thrb

Gene Symbol Gene ID Gene Info
thrb
ENSDARG00000021163 thyroid hormone receptor beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
thrbdr11_v1_chr19_-_17526735_17526735-0.737.0e-17Click!

Activity profile of thrb motif

Sorted Z-values of thrb motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr22_-_2886937 7.49 ENSDART00000063533
aqp12
aquaporin 12
chr5_+_28857969 6.52 ENSDART00000149850
si:ch211-186e20.2
si:ch211-186e20.2
chr13_-_22862133 6.34 ENSDART00000138563
pbld2
phenazine biosynthesis-like protein domain containing 2
chr5_+_28797771 4.75 ENSDART00000188845
ENSDART00000149066
si:ch211-186e20.7
si:ch211-186e20.7
chr15_-_23645810 4.59 ENSDART00000168845
ckmb
creatine kinase, muscle b
chr15_+_5088210 3.70 ENSDART00000183423
mxf
myxovirus (influenza virus) resistance F
chr20_-_35750810 3.01 ENSDART00000153072
adgrf8
adhesion G protein-coupled receptor F8
chr15_-_34878388 2.70 ENSDART00000154094
mgat1a
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase a
chr6_+_60112200 2.68 ENSDART00000008243
prelid3b
PRELI domain containing 3
chr3_+_34846201 1.90 ENSDART00000055263
itga3a
integrin, alpha 3a
chr5_+_38673168 1.28 ENSDART00000135267
si:dkey-58f10.12
si:dkey-58f10.12
chr13_+_33462232 1.18 ENSDART00000177841
zgc:136302
zgc:136302
chr2_+_19163965 0.94 ENSDART00000166073
elovl1a
ELOVL fatty acid elongase 1a
chr15_-_34408777 0.81 ENSDART00000139934
agmo
alkylglycerol monooxygenase
chr7_-_8156169 0.80 ENSDART00000182960
ENSDART00000190184
ENSDART00000190885
ENSDART00000189867
ENSDART00000160836
si:cabz01030277.1
si:ch211-163c2.3
si:cabz01030277.1
si:ch211-163c2.3
chr2_+_10766744 0.74 ENSDART00000015379
gfi1aa
growth factor independent 1A transcription repressor a
chr4_-_64142389 0.67 ENSDART00000172126
BX914205.3

chr4_-_64141714 0.61 ENSDART00000128628
BX914205.3

chr22_-_6219092 0.61 ENSDART00000150040
si:ch211-274k16.2
si:ch211-274k16.2
chr6_-_29537219 0.44 ENSDART00000180262
pex5la
peroxisomal biogenesis factor 5-like a
chr7_-_8014186 0.16 ENSDART00000190012
si:cabz01030277.1
si:cabz01030277.1
chr6_-_51556308 0.10 ENSDART00000149033
rbl1
retinoblastoma-like 1 (p107)
chr19_-_32804535 0.09 ENSDART00000175613
ENSDART00000052098
nt5c1aa
5'-nucleotidase, cytosolic IAa
chr2_-_5199431 0.05 ENSDART00000063384
phb2a
prohibitin 2a

Network of associatons between targets according to the STRING database.

First level regulatory network of thrb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.6 GO:0046314 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.2 3.7 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.2 0.8 GO:0046485 ether lipid metabolic process(GO:0046485)
0.1 7.5 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.1 11.3 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.1 1.0 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.9 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.4 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 2.7 GO:0015914 phospholipid transport(GO:0015914)
0.0 2.7 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.7 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.0 1.9 GO:0007229 integrin-mediated signaling pathway(GO:0007229)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.7 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.1 2.7 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 1.9 GO:0008305 integrin complex(GO:0008305)
0.0 15.9 GO:0005615 extracellular space(GO:0005615)
0.0 0.4 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.7 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.4 2.7 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.4 4.6 GO:0004111 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.1 11.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.8 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.1 1.0 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.1 0.4 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 0.9 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 6.3 GO:0016853 isomerase activity(GO:0016853)
0.0 7.5 GO:0015267 channel activity(GO:0015267) passive transmembrane transporter activity(GO:0022803)