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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for tlx1

Z-value: 1.19

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Transcription factors associated with tlx1

Gene Symbol Gene ID Gene Info
tlx1
ENSDARG00000003965 T cell leukemia homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tlx1dr11_v1_chr13_-_28272299_28272299-0.103.6e-01Click!

Activity profile of tlx1 motif

Sorted Z-values of tlx1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr25_-_4146947 25.97 ENSDART00000129268
fads2
fatty acid desaturase 2
chr20_+_10539293 19.55 ENSDART00000182265
serpina1l
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, like
chr20_+_10545514 19.16 ENSDART00000153667
serpina1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr20_+_25581627 13.81 ENSDART00000030229
cyp2p9
cytochrome P450, family 2, subfamily P, polypeptide 9
chr22_+_38229321 12.89 ENSDART00000132670
ENSDART00000104504
si:ch211-284e20.8
si:ch211-284e20.8
chr12_+_33403694 11.08 ENSDART00000124083
fasn
fatty acid synthase
chr7_+_52122224 10.29 ENSDART00000174268
cyp2x12
cytochrome P450, family 2, subfamily X, polypeptide 12
chr13_-_9895564 9.85 ENSDART00000169831
ENSDART00000142629
si:ch211-117n7.6
si:ch211-117n7.6
chr3_-_15081874 9.41 ENSDART00000192532
nme4
NME/NM23 nucleoside diphosphate kinase 4
chr25_-_30394746 8.88 ENSDART00000185346
si:ch211-93f2.1
si:ch211-93f2.1
chr7_+_52135791 8.70 ENSDART00000098705
cyp2x12
cytochrome P450, family 2, subfamily X, polypeptide 12
chr7_-_52096498 7.85 ENSDART00000098688
ENSDART00000098690
cyp2x10.2
cytochrome P450, family 2, subfamily X, polypeptide 10.2
chr14_-_25444774 7.53 ENSDART00000183448
slc26a2
solute carrier family 26 (anion exchanger), member 2
chr18_+_40462445 7.43 ENSDART00000087645
ugt5c2
UDP glucuronosyltransferase 5 family, polypeptide C2
chr13_+_37040789 7.16 ENSDART00000063412
esr2b
estrogen receptor 2b
chr13_+_28761998 6.68 ENSDART00000146581
prom2
prominin 2
chr24_-_21903360 6.64 ENSDART00000091252
spata13
spermatogenesis associated 13
chr11_-_34147205 6.53 ENSDART00000173216
atp13a3
ATPase 13A3
chr25_-_17378881 6.50 ENSDART00000064586
cyp2x7
cytochrome P450, family 2, subfamily X, polypeptide 7
chr4_-_14531687 6.42 ENSDART00000182093
ENSDART00000159447
plxnb2a
plexin b2a
chr7_+_14291323 5.70 ENSDART00000053521
rhcga
Rh family, C glycoprotein a
chr2_-_17827983 5.35 ENSDART00000166518
ptprfb
protein tyrosine phosphatase, receptor type, f, b
chr20_+_34320635 5.07 ENSDART00000153207
ivns1abpa
influenza virus NS1A binding protein a
chr7_+_37377335 4.81 ENSDART00000111842
sall1a
spalt-like transcription factor 1a
chr7_-_51953613 4.79 ENSDART00000142042
cyp2x10.2
cytochrome P450, family 2, subfamily X, polypeptide 10.2
chr25_-_31118923 4.79 ENSDART00000009126
ENSDART00000188286
kras
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
chr15_-_20745513 4.56 ENSDART00000187438
tpst1
tyrosylprotein sulfotransferase 1
chr11_+_14937904 4.31 ENSDART00000185103
CR550302.3

chr6_-_39199070 4.27 ENSDART00000131793
c1galt1b
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1b
chr17_-_50233493 3.91 ENSDART00000172266
fosaa
v-fos FBJ murine osteosarcoma viral oncogene homolog Aa
chr8_-_53108207 3.89 ENSDART00000111023
b3galt4
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
chr20_+_16750177 3.82 ENSDART00000185357
calm1b
calmodulin 1b
chr1_-_56363108 3.71 ENSDART00000021878
gcgrb
glucagon receptor b
chr4_-_4250317 3.68 ENSDART00000103316
cd9b
CD9 molecule b
chr7_+_57109214 3.62 ENSDART00000135068
ENSDART00000098412
enosf1
enolase superfamily member 1
chr2_+_30969029 3.50 ENSDART00000085242
lpin2
lipin 2
chr4_-_18281070 3.29 ENSDART00000135330
ENSDART00000179075
ENSDART00000046871
uhrf1bp1l
UHRF1 binding protein 1-like
chr14_+_16036139 3.16 ENSDART00000190733
prelid1a
PRELI domain containing 1a
chr7_+_57108823 3.15 ENSDART00000184943
ENSDART00000055956
enosf1
enolase superfamily member 1
chr3_+_61391636 3.11 ENSDART00000126417
bri3
brain protein I3
chr13_+_15682803 3.09 ENSDART00000188063
CR931980.1

chr2_-_7800702 3.07 ENSDART00000146360
tbl1xr1b
transducin (beta)-like 1 X-linked receptor 1b
chr5_+_22791686 3.05 ENSDART00000014806
npas2
neuronal PAS domain protein 2
chr14_+_31865324 3.00 ENSDART00000039880
tm9sf5
transmembrane 9 superfamily protein member 5
chr2_+_37207461 2.96 ENSDART00000138952
ENSDART00000132856
ENSDART00000137272
ENSDART00000143468
apoda.2
apolipoprotein Da, duplicate 2
chr8_+_44623540 2.95 ENSDART00000141513
grk5l
G protein-coupled receptor kinase 5 like
chr14_+_31865099 2.88 ENSDART00000189124
tm9sf5
transmembrane 9 superfamily protein member 5
chr23_-_38497705 2.87 ENSDART00000109493
tshz2
teashirt zinc finger homeobox 2
chr6_-_21873266 2.84 ENSDART00000151658
ENSDART00000151152
ENSDART00000151179
si:dkey-19e4.5
si:dkey-19e4.5
chr19_-_30403922 2.81 ENSDART00000181841
agr2
anterior gradient 2
chr17_+_52822422 2.80 ENSDART00000158273
ENSDART00000161414
meis2a
Meis homeobox 2a
chr19_-_30404096 2.80 ENSDART00000103475
agr2
anterior gradient 2
chr23_-_18572521 2.79 ENSDART00000138599
ssr4
signal sequence receptor, delta
chr7_-_51953807 2.72 ENSDART00000174102
ENSDART00000145645
ENSDART00000052054
cyp2x10.2
cytochrome P450, family 2, subfamily X, polypeptide 10.2
chr9_-_34296406 2.72 ENSDART00000125451
ildr2
immunoglobulin-like domain containing receptor 2
chr23_-_18572685 2.68 ENSDART00000047175
ssr4
signal sequence receptor, delta
chr17_-_31308658 2.66 ENSDART00000124505
bahd1
bromo adjacent homology domain containing 1
chr8_-_1266181 2.62 ENSDART00000148654
ENSDART00000149924
cdc14b
cell division cycle 14B
chr11_+_14284866 2.60 ENSDART00000163729
si:ch211-262i1.3
si:ch211-262i1.3
chr5_-_57526807 2.55 ENSDART00000022866
pisd
phosphatidylserine decarboxylase
chr20_-_53949798 2.41 ENSDART00000153435
ppp2r5cb
protein phosphatase 2, regulatory subunit B', gamma b
chr1_+_4101741 2.39 ENSDART00000163793
slitrk6
SLIT and NTRK-like family, member 6
chr18_-_2433011 2.27 ENSDART00000181922
ENSDART00000193276
CR769778.1

chr7_-_28647959 2.22 ENSDART00000150148
slc7a6
solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
chr16_+_21426524 2.16 ENSDART00000182869
gsdmeb
gasdermin Eb
chr11_+_37265692 2.15 ENSDART00000184691
il17rc
interleukin 17 receptor C
chr19_-_8926575 2.13 ENSDART00000080897
rprd2a
regulation of nuclear pre-mRNA domain containing 2a
chr18_-_127873 2.03 ENSDART00000148490
trpm7
transient receptor potential cation channel, subfamily M, member 7
chr1_-_58059134 1.99 ENSDART00000160970
caspb
caspase b
chr18_-_39473055 1.98 ENSDART00000122930
scg3
secretogranin III
chr23_-_36446307 1.94 ENSDART00000136623
zgc:174906
zgc:174906
chr17_+_10578823 1.93 ENSDART00000134610
mgaa
MGA, MAX dimerization protein a
chr16_-_22585289 1.91 ENSDART00000134239
ENSDART00000193959
ENSDART00000077998
si:dkey-238m4.3
cgna
si:dkey-238m4.3
cingulin a
chr18_+_7543347 1.82 ENSDART00000103467
arf5
ADP-ribosylation factor 5
chr23_+_21278948 1.75 ENSDART00000156701
ENSDART00000033970
ubr4
ubiquitin protein ligase E3 component n-recognin 4
chr5_+_31283576 1.73 ENSDART00000133743
camkk1a
calcium/calmodulin-dependent protein kinase kinase 1, alpha a
chr18_+_41560822 1.69 ENSDART00000158503
baz1b
bromodomain adjacent to zinc finger domain, 1B
chr2_-_59285085 1.60 ENSDART00000131880
ftr34
finTRIM family, member 34
chr7_+_47316944 1.60 ENSDART00000173534
dpy19l3
dpy-19 like C-mannosyltransferase 3
chr3_-_34599662 1.58 ENSDART00000055259
nmrk1
nicotinamide riboside kinase 1
chr22_-_22416337 1.46 ENSDART00000142947
ENSDART00000089569
camsap2a
calmodulin regulated spectrin-associated protein family, member 2a
chr6_+_2951645 1.46 ENSDART00000183181
ENSDART00000181271
ptprfa
protein tyrosine phosphatase, receptor type, f, a
chr11_-_103136 1.46 ENSDART00000173308
ENSDART00000162982
elmo2
engulfment and cell motility 2
chr8_+_44722140 1.45 ENSDART00000163381
elmod3
ELMO/CED-12 domain containing 3
chr8_-_31053872 1.43 ENSDART00000109885
snrnp200
small nuclear ribonucleoprotein 200 (U5)
chr3_-_37681824 1.40 ENSDART00000185858
gpatch8
G patch domain containing 8
chr9_-_24242592 1.36 ENSDART00000039399
cavin2a
caveolae associated protein 2a
chr3_+_24482999 1.36 ENSDART00000059179
nptxra
neuronal pentraxin receptor a
chr3_+_57038033 1.29 ENSDART00000162930
bahcc1a
BAH domain and coiled-coil containing 1a
chr15_-_38202630 1.25 ENSDART00000183772
rhoga
ras homolog family member Ga
chr20_-_3390406 1.25 ENSDART00000136987
rev3l
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr8_+_9699111 1.24 ENSDART00000111853
gripap1
GRIP1 associated protein 1
chr24_+_17262879 1.23 ENSDART00000145949
bmi1a
bmi1 polycomb ring finger oncogene 1a
chr22_-_16400484 1.18 ENSDART00000135987
lama3
laminin, alpha 3
chr8_-_39822917 1.18 ENSDART00000067843
zgc:162025
zgc:162025
chr19_+_40379771 1.14 ENSDART00000017917
ENSDART00000110699
vps50
vps50
VPS50 EARP/GARPII complex subunit
VPS50 EARP/GARPII complex subunit
chr24_+_7884880 1.10 ENSDART00000139467
bmp6
bone morphogenetic protein 6
chr2_+_50722439 1.02 ENSDART00000188927
fyco1b
FYVE and coiled-coil domain containing 1b
chr16_+_14029283 0.99 ENSDART00000146165
ENSDART00000132075
rusc1
RUN and SH3 domain containing 1
chr13_-_35760969 0.95 ENSDART00000127476
erlec1
endoplasmic reticulum lectin 1
chr16_-_9453591 0.94 ENSDART00000126154
prpf3
PRP3 pre-mRNA processing factor 3 homolog (yeast)
chr13_-_15865335 0.94 ENSDART00000135186
si:ch211-57f7.7
si:ch211-57f7.7
chr5_-_30074332 0.93 ENSDART00000147963
bco2a
beta-carotene oxygenase 2a
chr11_-_13341483 0.91 ENSDART00000164978
mast3b
microtubule associated serine/threonine kinase 3b
chr16_-_11928774 0.87 ENSDART00000183229
cd4-1
CD4-1 molecule
chr15_-_18091157 0.85 ENSDART00000153848
phldb1b
pleckstrin homology-like domain, family B, member 1b
chr23_-_45504991 0.85 ENSDART00000148761
col24a1
collagen type XXIV alpha 1
chr5_+_28398449 0.85 ENSDART00000165292
nsmfb
NMDA receptor synaptonuclear signaling and neuronal migration factor b
chr13_+_18371208 0.84 ENSDART00000138172
ccar1
cell division cycle and apoptosis regulator 1
chr5_-_32338866 0.83 ENSDART00000017956
ENSDART00000047670
dab2
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr13_-_35761266 0.82 ENSDART00000190217
erlec1
endoplasmic reticulum lectin 1
chr11_-_13341051 0.78 ENSDART00000121872
mast3b
microtubule associated serine/threonine kinase 3b
chr2_-_59285407 0.74 ENSDART00000181616
ftr34
finTRIM family, member 34
chr14_-_32503363 0.72 ENSDART00000034883
mcf2a
MCF.2 cell line derived transforming sequence a
chr2_-_59303338 0.72 ENSDART00000100987
ENSDART00000140840
ftr35
finTRIM family, member 35
chr23_-_6765653 0.71 ENSDART00000192310
FP102169.1

chr6_+_53349966 0.70 ENSDART00000167079
si:ch211-161c3.5
si:ch211-161c3.5
chr22_+_11857356 0.70 ENSDART00000179540
mras
muscle RAS oncogene homolog
chr7_-_24472991 0.69 ENSDART00000121684
nat8l
N-acetyltransferase 8-like
chr5_+_63329608 0.69 ENSDART00000139180
si:ch73-376l24.3
si:ch73-376l24.3
chr7_-_22132265 0.65 ENSDART00000125284
ENSDART00000112978
nlgn2a
neuroligin 2a
chr17_-_22067451 0.63 ENSDART00000156872
ttbk1b
tau tubulin kinase 1b
chr12_-_2518178 0.63 ENSDART00000128677
ENSDART00000086510
mapk8b
mitogen-activated protein kinase 8b
chr2_-_37352514 0.58 ENSDART00000140498
ENSDART00000186422
skila
SKI-like proto-oncogene a
chr17_+_19630068 0.56 ENSDART00000182619
rgs7a
regulator of G protein signaling 7a
chr14_+_21820034 0.55 ENSDART00000122739
ctbp1
C-terminal binding protein 1
chr15_+_23528010 0.53 ENSDART00000152786
si:dkey-182i3.8
si:dkey-182i3.8
chr1_+_49568335 0.53 ENSDART00000142957
col17a1a
collagen, type XVII, alpha 1a
chr11_-_17755444 0.52 ENSDART00000154627
eogt
EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
chr20_-_29499363 0.51 ENSDART00000152889
ENSDART00000153252
ENSDART00000170972
ENSDART00000166420
ENSDART00000163079
rrm2
ribonucleotide reductase M2 polypeptide
chr4_+_74131530 0.46 ENSDART00000174125
CABZ01072523.1

chr9_+_16449398 0.45 ENSDART00000006787
epha3
eph receptor A3
chr10_-_29827000 0.40 ENSDART00000131418
zpr1
ZPR1 zinc finger
chr12_+_13405445 0.38 ENSDART00000089042
kcnh4b
potassium voltage-gated channel, subfamily H (eag-related), member 4b
chr5_+_61839707 0.36 ENSDART00000163051
CR759879.1
Danio rerio interferon-induced protein with tetratricopeptide repeats 5 (LOC572297), mRNA.
chr19_-_47571797 0.35 ENSDART00000166180
ENSDART00000168134
rrm2
ribonucleotide reductase M2 polypeptide
chr9_-_25089536 0.34 ENSDART00000143479
rubcnl
RUN and cysteine rich domain containing beclin 1 interacting protein like
chr8_-_16712111 0.26 ENSDART00000184147
ENSDART00000180419
ENSDART00000076600
rpe65c
retinal pigment epithelium-specific protein 65c
chr3_-_19561058 0.26 ENSDART00000079323
zgc:163079
zgc:163079
chr21_+_39336285 0.22 ENSDART00000139677
si:ch211-274p24.4
si:ch211-274p24.4
chr8_-_34052019 0.19 ENSDART00000040126
ENSDART00000159208
ENSDART00000048994
ENSDART00000098822
pbx3b
pre-B-cell leukemia homeobox 3b
chr3_-_27061637 0.19 ENSDART00000157126
atf7ip2
activating transcription factor 7 interacting protein 2
chr9_-_44939104 0.18 ENSDART00000192903
vil1
villin 1
chr10_-_7857494 0.17 ENSDART00000143215
inpp5ja
inositol polyphosphate-5-phosphatase Ja
chr1_+_35194454 0.16 ENSDART00000165389
sc:d189
sc:d189
chr6_+_39184236 0.10 ENSDART00000156187
tac3b
tachykinin 3b
chr15_+_22722684 0.07 ENSDART00000156760
grik4
glutamate receptor, ionotropic, kainate 4
chr4_-_46648979 0.06 ENSDART00000162101
BX927193.2

Network of associatons between targets according to the STRING database.

First level regulatory network of tlx1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 9.8 GO:0046462 phosphatidylserine catabolic process(GO:0006660) monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
1.1 54.7 GO:0042738 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.8 6.8 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.7 7.2 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.7 5.7 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.7 2.0 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.6 51.6 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.6 9.4 GO:0046051 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.6 4.6 GO:0006477 protein sulfation(GO:0006477) peptidyl-tyrosine sulfation(GO:0006478)
0.6 5.6 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.5 1.6 GO:0018406 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.5 26.0 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636)
0.4 1.2 GO:0097065 anterior head development(GO:0097065)
0.3 4.8 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.3 1.2 GO:0099563 modification of synaptic structure(GO:0099563)
0.3 7.5 GO:0008272 sulfate transport(GO:0008272)
0.3 2.6 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.2 1.4 GO:0000393 spliceosomal conformational changes to generate catalytic conformation(GO:0000393)
0.2 2.5 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.2 1.0 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.2 0.5 GO:0007509 mesoderm migration involved in gastrulation(GO:0007509)
0.1 0.8 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.1 3.0 GO:1902017 regulation of cilium assembly(GO:1902017)
0.1 1.2 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.1 5.5 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.1 2.4 GO:0031952 regulation of protein autophosphorylation(GO:0031952)
0.1 0.8 GO:1905207 regulation of cardiocyte differentiation(GO:1905207) regulation of cardiac muscle cell differentiation(GO:2000725)
0.1 0.9 GO:0016121 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.1 3.5 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.1 3.0 GO:0007568 aging(GO:0007568)
0.1 1.1 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111)
0.1 0.8 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.1 3.7 GO:0010906 regulation of glucose metabolic process(GO:0010906)
0.1 0.9 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.1 1.2 GO:0035701 hematopoietic stem cell migration(GO:0035701)
0.1 3.0 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.1 0.3 GO:0016117 tetraterpenoid metabolic process(GO:0016108) tetraterpenoid biosynthetic process(GO:0016109) carotenoid metabolic process(GO:0016116) carotenoid biosynthetic process(GO:0016117) xanthophyll metabolic process(GO:0016122) xanthophyll biosynthetic process(GO:0016123) zeaxanthin metabolic process(GO:1901825) zeaxanthin biosynthetic process(GO:1901827)
0.1 2.0 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919)
0.1 1.9 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.1 0.6 GO:0097090 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.1 3.7 GO:0007338 single fertilization(GO:0007338)
0.1 6.8 GO:0009063 cellular amino acid catabolic process(GO:0009063)
0.1 0.2 GO:0033137 negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.1 0.7 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.1 3.1 GO:0016575 histone deacetylation(GO:0016575)
0.1 3.2 GO:0015914 phospholipid transport(GO:0015914)
0.0 0.2 GO:0072673 lamellipodium morphogenesis(GO:0072673) regulation of lamellipodium morphogenesis(GO:2000392)
0.0 1.2 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 0.9 GO:0071350 interleukin-15-mediated signaling pathway(GO:0035723) response to interleukin-15(GO:0070672) cellular response to interleukin-15(GO:0071350)
0.0 9.9 GO:0048701 embryonic cranial skeleton morphogenesis(GO:0048701)
0.0 2.2 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 2.7 GO:0007492 endoderm development(GO:0007492)
0.0 0.6 GO:0048263 determination of dorsal identity(GO:0048263)
0.0 1.1 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0 1.1 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.6 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.0 0.1 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.0 2.2 GO:0042472 inner ear morphogenesis(GO:0042472)
0.0 1.2 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 5.3 GO:0072657 protein localization to membrane(GO:0072657)
0.0 4.7 GO:0006874 cellular calcium ion homeostasis(GO:0006874)
0.0 0.5 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 3.9 GO:0006486 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
0.0 0.6 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.3 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.7 GO:0031124 mRNA 3'-end processing(GO:0031124)
0.0 1.7 GO:0006338 chromatin remodeling(GO:0006338)
0.0 1.5 GO:0006909 phagocytosis(GO:0006909)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 6.3 GO:0071914 prominosome(GO:0071914)
0.6 3.0 GO:1990513 CLOCK-BMAL transcription complex(GO:1990513)
0.5 2.0 GO:0061702 inflammasome complex(GO:0061702)
0.4 1.1 GO:1990745 EARP complex(GO:1990745)
0.3 0.8 GO:0005592 collagen type XI trimer(GO:0005592)
0.2 0.6 GO:0060077 inhibitory synapse(GO:0060077)
0.2 1.2 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.1 1.1 GO:0036449 microtubule minus-end(GO:0036449)
0.1 1.2 GO:0042575 DNA polymerase complex(GO:0042575)
0.1 2.0 GO:0030667 secretory granule membrane(GO:0030667)
0.1 2.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 3.1 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.1 4.6 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.1 0.9 GO:0045180 basal cortex(GO:0045180)
0.1 40.3 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 2.5 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.8 GO:0016363 nuclear matrix(GO:0016363)
0.0 1.0 GO:0071141 SMAD protein complex(GO:0071141)
0.0 1.6 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 3.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 2.6 GO:0072686 mitotic spindle(GO:0072686)
0.0 0.2 GO:0032433 filopodium tip(GO:0032433)
0.0 0.9 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.0 0.9 GO:0035102 PRC1 complex(GO:0035102)
0.0 1.4 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 1.4 GO:0005776 autophagosome(GO:0005776)
0.0 13.4 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 3.1 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 2.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 30.0 GO:0005615 extracellular space(GO:0005615)
0.0 2.1 GO:0016591 DNA-directed RNA polymerase II, holoenzyme(GO:0016591)
0.0 0.1 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.9 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 11.3 GO:0005576 extracellular region(GO:0005576)
0.0 3.9 GO:0000139 Golgi membrane(GO:0000139)
0.0 1.2 GO:0005635 nuclear envelope(GO:0005635)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 7.2 GO:1903924 estradiol binding(GO:1903924)
0.8 54.7 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.8 9.8 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.7 3.7 GO:0016519 gastric inhibitory peptide receptor activity(GO:0016519)
0.6 4.6 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.5 3.2 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.4 2.8 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.4 7.5 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.3 38.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.3 9.4 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.3 12.9 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.2 1.7 GO:0035173 histone kinase activity(GO:0035173)
0.2 5.7 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.2 3.0 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.2 2.1 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.2 2.0 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.1 2.0 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.1 5.1 GO:0019003 GDP binding(GO:0019003)
0.1 7.4 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 2.4 GO:0072542 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.1 0.9 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 6.3 GO:0015485 cholesterol binding(GO:0015485)
0.1 1.1 GO:0070700 BMP receptor binding(GO:0070700)
0.1 3.5 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.9 GO:0003834 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.1 2.1 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 6.8 GO:0016836 hydro-lyase activity(GO:0016836)
0.1 3.9 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.1 0.5 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.1 1.1 GO:0030507 spectrin binding(GO:0030507)
0.1 1.4 GO:0005080 protein kinase C binding(GO:0005080)
0.1 0.3 GO:0052885 retinol isomerase activity(GO:0050251) all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity(GO:0052885)
0.1 0.6 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 2.5 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 1.2 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 1.6 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 5.6 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.9 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 7.7 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 2.2 GO:0015179 L-amino acid transmembrane transporter activity(GO:0015179)
0.0 0.8 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.6 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 1.5 GO:0017124 SH3 domain binding(GO:0017124)
0.0 3.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.2 GO:0034594 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485) phosphatidylinositol trisphosphate phosphatase activity(GO:0034594)
0.0 7.4 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 16.5 GO:0016491 oxidoreductase activity(GO:0016491)
0.0 6.5 GO:0016887 ATPase activity(GO:0016887)
0.0 3.6 GO:0003682 chromatin binding(GO:0003682)
0.0 1.7 GO:0000287 magnesium ion binding(GO:0000287)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 21.7 PID HNF3A PATHWAY FOXA1 transcription factor network
0.4 4.8 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.2 11.1 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 3.0 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.2 6.6 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 1.8 PID PI3KCI PATHWAY Class I PI3K signaling events
0.1 1.2 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 2.6 PID PLK1 PATHWAY PLK1 signaling events
0.0 1.5 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 1.0 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 1.1 PID BMP PATHWAY BMP receptor signaling
0.0 0.8 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.8 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.6 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.7 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.0 0.9 PID E2F PATHWAY E2F transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 26.0 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.9 11.1 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.8 4.8 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.5 10.3 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.3 21.1 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.3 3.5 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 0.8 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.1 3.0 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 9.8 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 5.5 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 1.4 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 1.2 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 0.8 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.2 REACTOME DNA REPAIR Genes involved in DNA Repair