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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for tp63

Z-value: 0.52

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Transcription factors associated with tp63

Gene Symbol Gene ID Gene Info
tp63
ENSDARG00000044356 tumor protein p63
tp63
ENSDARG00000113627 tumor protein p63

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tp63dr11_v1_chr6_+_28877306_28877441-0.151.6e-01Click!

Activity profile of tp63 motif

Sorted Z-values of tp63 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_31035155 4.86 ENSDART00000161882
bzw2
basic leucine zipper and W2 domains 2
chr19_-_31035325 4.56 ENSDART00000147504
bzw2
basic leucine zipper and W2 domains 2
chr14_+_24241241 4.22 ENSDART00000022377
nkx2.5
NK2 homeobox 5
chr17_-_14671098 3.98 ENSDART00000037371
ppp1r13ba
protein phosphatase 1, regulatory subunit 13Ba
chr14_+_22132896 3.52 ENSDART00000138274
ccng1
cyclin G1
chr23_-_17470146 3.46 ENSDART00000002398
trim101
tripartite motif containing 101
chr11_-_11518469 3.21 ENSDART00000104254
krt15
keratin 15
chr1_+_52735484 2.84 ENSDART00000182076
CABZ01021532.1

chr20_-_27325258 2.29 ENSDART00000152917
asb2a.1
ankyrin repeat and SOCS box containing 2a, tandem duplicate 1
chr20_-_1314355 2.17 ENSDART00000152436
pcmt
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr15_-_29387446 2.13 ENSDART00000145976
ENSDART00000035096
serpinh1b
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b
chr14_-_9522364 1.79 ENSDART00000054689
atoh8
atonal bHLH transcription factor 8
chr2_+_36691771 1.75 ENSDART00000131978
ptx3b
pentraxin 3, long b
chr20_-_1314537 1.69 ENSDART00000144288
pcmt
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr16_-_41717063 1.60 ENSDART00000084610
cep85
centrosomal protein 85
chr5_-_1999417 1.47 ENSDART00000155437
ENSDART00000145781
si:ch211-160e1.5
si:ch211-160e1.5
chr24_+_35564668 1.41 ENSDART00000122734
cebpd
CCAAT/enhancer binding protein (C/EBP), delta
chr25_+_34641536 1.38 ENSDART00000167033
CABZ01079011.1

chr7_-_50914526 1.35 ENSDART00000160398
ankrd46b
ankyrin repeat domain 46b
chr16_+_20904754 1.28 ENSDART00000006043
hoxa11b
homeobox A11b
chr9_-_15424639 1.19 ENSDART00000124346
fn1a
fibronectin 1a
chr15_-_5157572 1.19 ENSDART00000174192
or128-10
odorant receptor, family E, subfamily 128, member 10
chr12_-_29301022 1.16 ENSDART00000187826
sh2d4bb
SH2 domain containing 4Bb
chr19_+_41173386 1.15 ENSDART00000142773
asb4
ankyrin repeat and SOCS box containing 4
chr17_+_45607580 1.14 ENSDART00000122583
si:ch211-202f3.4
si:ch211-202f3.4
chr10_+_5135842 1.12 ENSDART00000132627
ENSDART00000162434
zgc:113274
zgc:113274
chr7_-_8324927 1.05 ENSDART00000102535
f13a1b
coagulation factor XIII, A1 polypeptide b
chr15_+_44053244 1.00 ENSDART00000059550
lrrc51
leucine rich repeat containing 51
chr21_+_40498628 0.97 ENSDART00000163454
coro6
coronin 6
chr17_-_14613711 0.94 ENSDART00000157345
sdsl
serine dehydratase-like
chr25_+_36292465 0.91 ENSDART00000152649
bmb
brambleberry
chr25_+_33033633 0.90 ENSDART00000192336
tln2b
talin 2b
chr8_-_26703195 0.86 ENSDART00000193439
ENSDART00000137968
si:dkey-159f12.2
si:dkey-159f12.2
chr15_+_21672700 0.86 ENSDART00000187043
si:dkey-40g16.5
si:dkey-40g16.5
chr10_-_10607118 0.85 ENSDART00000101089
dbh
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr5_+_38913621 0.81 ENSDART00000137112
fras1
Fraser extracellular matrix complex subunit 1
chr7_-_60156409 0.74 ENSDART00000006802
cct7
chaperonin containing TCP1, subunit 7 (eta)
chr17_+_53250802 0.72 ENSDART00000143819
VASH1
vasohibin 1
chr6_+_54538948 0.60 ENSDART00000149270
tulp1b
tubby like protein 1b
chr15_-_5203371 0.56 ENSDART00000141582
or128-8
odorant receptor, family E, subfamily 128, member 8
chr16_+_41717313 0.56 ENSDART00000015170
ENSDART00000075937
mtdhb
metadherin b
chr13_+_25422009 0.55 ENSDART00000057686
calhm2
calcium homeostasis modulator 2
chr10_+_39091353 0.54 ENSDART00000125986
si:ch73-1a9.4
si:ch73-1a9.4
chr15_-_10455438 0.53 ENSDART00000158958
ENSDART00000192971
ENSDART00000162133
ENSDART00000185071
ENSDART00000192444
ENSDART00000165668
ENSDART00000175825
tenm4
teneurin transmembrane protein 4
chr25_+_4787607 0.49 ENSDART00000159422
myo5c
myosin VC
chr25_+_17871089 0.47 ENSDART00000133725
btbd10a
BTB (POZ) domain containing 10a
chr13_-_2060713 0.46 ENSDART00000038434
hcrtr2
hypocretin (orexin) receptor 2
chr7_+_8324506 0.42 ENSDART00000168110
si:dkey-185m8.2
si:dkey-185m8.2
chr23_-_1056808 0.38 ENSDART00000081961
zgc:113423
zgc:113423
chr23_-_19827411 0.38 ENSDART00000187964
haus7
HAUS augmin-like complex, subunit 7
chr7_+_22702437 0.37 ENSDART00000182054
si:dkey-165a24.9
si:dkey-165a24.9
chr4_+_23127284 0.34 ENSDART00000122675
mdm2
MDM2 oncogene, E3 ubiquitin protein ligase
chr22_+_21305682 0.34 ENSDART00000023521
odf3l2
outer dense fiber of sperm tails 3-like 2
chr13_+_25421531 0.33 ENSDART00000158093
calhm2
calcium homeostasis modulator 2
chr3_-_28120092 0.32 ENSDART00000151143
rbfox1
RNA binding fox-1 homolog 1
chr25_+_2415131 0.31 ENSDART00000162210
zmp:0000000932
zmp:0000000932
chr9_-_3958533 0.31 ENSDART00000129091
ubr3
ubiquitin protein ligase E3 component n-recognin 3
chr17_+_30450163 0.29 ENSDART00000104257
lpin1
lipin 1
chr11_+_691734 0.25 ENSDART00000191463
timp4.1
TIMP metallopeptidase inhibitor 4, tandem duplicate 1
chr7_+_26138240 0.25 ENSDART00000193750
ENSDART00000184942
nat16
N-acetyltransferase 16
chr18_-_17399291 0.25 ENSDART00000192075
ENSDART00000060949
ENSDART00000188506
zfpm1
zinc finger protein, FOG family member 1
chr8_-_38506339 0.24 ENSDART00000054558
ENSDART00000141623
foxb2
forkhead box B2
chr14_-_733565 0.22 ENSDART00000158097
tlr1
toll-like receptor 1
chr2_-_26563978 0.22 ENSDART00000150016
glis1a
GLIS family zinc finger 1a
chr4_+_23126558 0.20 ENSDART00000162859
mdm2
MDM2 oncogene, E3 ubiquitin protein ligase
chr23_+_39346774 0.17 ENSDART00000190985
src
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr2_-_37837472 0.16 ENSDART00000165347
mettl17
methyltransferase like 17
chr7_+_22702225 0.16 ENSDART00000173672
si:dkey-165a24.9
si:dkey-165a24.9
chr22_+_569565 0.16 ENSDART00000037069
usp49
ubiquitin specific peptidase 49
chr17_+_43623598 0.12 ENSDART00000154138
znf365
zinc finger protein 365
chr17_+_38724473 0.11 ENSDART00000075792
GPR68
G protein-coupled receptor 68
chr8_+_2487883 0.07 ENSDART00000101841
dynll1
dynein, light chain, LC8-type 1
chr21_-_45613564 0.06 ENSDART00000160324
LO018363.1

chr17_-_7861219 0.06 ENSDART00000148604
syne1b
spectrin repeat containing, nuclear envelope 1b
chr12_+_26670778 0.06 ENSDART00000144355
arhgap12b
Rho GTPase activating protein 12b
chr7_-_56606752 0.05 ENSDART00000138714
sult5a1
sulfotransferase family 5A, member 1
chr3_+_43086548 0.05 ENSDART00000163579
si:dkey-43p13.5
si:dkey-43p13.5
chr23_+_44307996 0.05 ENSDART00000042430
dlg4b
discs, large homolog 4b (Drosophila)
chr13_-_12581388 0.05 ENSDART00000079655
enpep
glutamyl aminopeptidase
chr14_-_30983011 0.04 ENSDART00000014095
rap2c
RAP2C, member of RAS oncogene family
chr12_-_4651988 0.03 ENSDART00000182836
si:ch211-255p10.4
si:ch211-255p10.4

Network of associatons between targets according to the STRING database.

First level regulatory network of tp63

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:1903779 regulation of cardiac conduction(GO:1903779)
0.6 1.8 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.3 0.8 GO:0042420 octopamine biosynthetic process(GO:0006589) dopamine catabolic process(GO:0042420) norepinephrine biosynthetic process(GO:0042421) octopamine metabolic process(GO:0046333)
0.2 0.9 GO:0006549 isoleucine metabolic process(GO:0006549) isoleucine biosynthetic process(GO:0009097)
0.2 0.9 GO:0007344 karyogamy(GO:0000741) pronuclear fusion(GO:0007344)
0.2 1.2 GO:0003319 cardioblast migration to the midline involved in heart rudiment formation(GO:0003319) acute-phase response(GO:0006953) establishment of epithelial cell apical/basal polarity(GO:0045198)
0.2 0.5 GO:0030186 melatonin metabolic process(GO:0030186)
0.1 0.5 GO:0032289 central nervous system myelin formation(GO:0032289)
0.1 0.5 GO:1904036 negative regulation of epithelial cell apoptotic process(GO:1904036)
0.1 1.1 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.1 3.5 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.1 0.3 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 2.1 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.2 GO:0030219 megakaryocyte differentiation(GO:0030219)
0.0 0.3 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0 0.2 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.0 0.8 GO:0071711 basement membrane organization(GO:0071711)
0.0 0.1 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.0 4.0 GO:0032259 methylation(GO:0032259)
0.0 0.6 GO:0061512 protein localization to cilium(GO:0061512)
0.0 0.6 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0005614 interstitial matrix(GO:0005614)
0.1 3.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 0.7 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.4 GO:0070652 HAUS complex(GO:0070652)
0.0 0.8 GO:0030667 secretory granule membrane(GO:0030667)
0.0 3.2 GO:0005882 intermediate filament(GO:0005882)
0.0 1.8 GO:0016607 nuclear speck(GO:0016607)
0.0 0.9 GO:0001726 ruffle(GO:0001726)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.9 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.3 0.8 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.2 0.9 GO:0016841 ammonia-lyase activity(GO:0016841)
0.2 4.0 GO:0002039 p53 binding(GO:0002039)
0.1 1.2 GO:0001948 glycoprotein binding(GO:0001948) proteoglycan binding(GO:0043394)
0.1 2.1 GO:0005518 collagen binding(GO:0005518)
0.1 3.5 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 1.1 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.1 GO:0030882 lipid antigen binding(GO:0030882)
0.0 1.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.9 GO:0005178 integrin binding(GO:0005178)
0.0 0.4 GO:0051011 microtubule minus-end binding(GO:0051011)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.7 PID P53 REGULATION PATHWAY p53 pathway
0.0 1.4 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 0.2 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.2 REACTOME DEFENSINS Genes involved in Defensins
0.0 0.7 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.5 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.3 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 1.4 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation