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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for tp73

Z-value: 0.66

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Transcription factors associated with tp73

Gene Symbol Gene ID Gene Info
ENSDARG00000017953 tumor protein p73

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tp73dr11_v1_chr8_+_48848200_488482000.161.1e-01Click!

Activity profile of tp73 motif

Sorted Z-values of tp73 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_25767610 6.26 ENSDART00000062406
calcium channel, voltage-dependent, L type, alpha 1S subunit, b
chr3_+_16229911 6.02 ENSDART00000121728
ribosomal protein L19
chr20_-_30376433 5.43 ENSDART00000190737
ribosomal protein S7
chr5_+_40837539 4.97 ENSDART00000188279
si:dkey-3h3.3
chr1_-_53714885 4.53 ENSDART00000026409
chaperonin containing TCP1, subunit 4 (delta)
chr12_+_22576404 4.44 ENSDART00000172053
capping protein (actin filament), gelsolin-like b
chr22_+_8536838 4.25 ENSDART00000132998
si:ch73-27e22.7
chr2_+_36691771 4.20 ENSDART00000131978
pentraxin 3, long b
chr3_-_39488639 4.05 ENSDART00000161644
zgc:100868
chr11_+_12175162 4.01 ENSDART00000125446
si:ch211-156l18.7
chr13_-_17464362 3.97 ENSDART00000145499
leucine rich melanocyte differentiation associated
chr21_-_20832482 3.92 ENSDART00000191928
complement component 6
chr25_+_34641536 3.88 ENSDART00000167033

chr3_-_39488482 3.83 ENSDART00000135192
zgc:100868
chr15_-_35960250 3.78 ENSDART00000186765
collagen, type IV, alpha 4
chr18_-_38270077 3.78 ENSDART00000185546
cell cycle associated protein 1b
chr13_-_4707018 3.63 ENSDART00000128422
oncoprotein induced transcript 3
chr24_+_14859238 3.46 ENSDART00000113859
ENSDART00000138227
cysteine-rich secretory protein LCCL domain containing 1a
chr14_+_22132896 3.45 ENSDART00000138274
cyclin G1
chr19_+_4061699 3.32 ENSDART00000158309
ENSDART00000166512
bloodthirsty-related gene family, member 25
bloodthirsty-related gene family, member 26
chr11_+_14333441 3.27 ENSDART00000171969
polypyrimidine tract binding protein 1b
chr3_+_31680592 3.19 ENSDART00000172456
myosin, light chain kinase 5
chr23_-_20345473 3.16 ENSDART00000140935
si:rp71-17i16.6
chr15_-_29387446 3.13 ENSDART00000145976
ENSDART00000035096
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b
chr13_-_17464654 3.13 ENSDART00000140312
leucine rich melanocyte differentiation associated
chr6_-_10902916 3.01 ENSDART00000122221
nuclear factor, erythroid 2-like 2b
chr3_+_8825382 2.97 ENSDART00000158893
si:dkeyp-30d6.2
chr12_+_5358409 2.97 ENSDART00000152632
phospholipase C, epsilon 1
chr5_+_27898226 2.92 ENSDART00000098604
ENSDART00000180251
ADAM metallopeptidase domain 28
chr14_-_16328331 2.86 ENSDART00000111262
protocadherin 12
chr6_-_2154137 2.78 ENSDART00000162656
transglutaminase 5, like
chr1_+_36651059 2.78 ENSDART00000187475
endothelin receptor type Aa
chr6_-_40885496 2.73 ENSDART00000189857
sirtuin 4
chr19_+_4068134 2.68 ENSDART00000158285
bloodthirsty-related gene family, member 26
chr20_-_1314355 2.56 ENSDART00000152436
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr7_+_19495905 2.54 ENSDART00000125584
ENSDART00000173774
si:ch211-212k18.8
chr5_+_6854498 2.38 ENSDART00000148663
elaC ribonuclease Z 1
chr21_+_26612777 2.23 ENSDART00000142667
estrogen-related receptor alpha
chr1_+_57371447 2.22 ENSDART00000152229
ENSDART00000181077
si:dkey-27j5.3
chr16_-_21489514 2.14 ENSDART00000149525
ENSDART00000148517
ENSDART00000146914
ENSDART00000186493
ENSDART00000193081
ENSDART00000186017
membrane protein, palmitoylated 6a (MAGUK p55 subfamily member 6)
chr18_+_20567542 2.13 ENSDART00000182585
BH3 interacting domain death agonist
chr1_+_11711503 2.09 ENSDART00000138355
si:dkey-26i13.8
chr16_-_19568795 2.01 ENSDART00000185141
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr1_+_55600504 1.87 ENSDART00000123946
uromodulin
chr11_+_30303785 1.87 ENSDART00000185610
ENSDART00000126815
UDP glucuronosyltransferase 1 family, polypeptide B5
chr10_+_2587234 1.75 ENSDART00000126937
wu:fb59d01
chr3_+_52545400 1.73 ENSDART00000184183
solute carrier family 27 (fatty acid transporter), member 1a
chr7_-_73848458 1.69 ENSDART00000041385
zgc:163061
chr5_-_26936861 1.68 ENSDART00000191032
HtrA serine peptidase 4
chr8_+_30747940 1.66 ENSDART00000098975
purinergic receptor P2X, ligand-gated ion channel, 4b
chr7_+_19495379 1.62 ENSDART00000180514
si:ch211-212k18.8
chr13_-_50546634 1.57 ENSDART00000192127

chr11_+_14287427 1.50 ENSDART00000180903
si:ch211-262i1.3
chr14_+_15484544 1.48 ENSDART00000188649

chr7_-_16596938 1.47 ENSDART00000134548
E2F transcription factor 8
chr12_-_44151296 1.46 ENSDART00000168734
si:ch73-329n5.3
chr15_-_4485828 1.46 ENSDART00000062868
transcription factor Dp-2
chr25_+_36292465 1.45 ENSDART00000152649
brambleberry
chr7_-_22941472 1.40 ENSDART00000190334
TNF superfamily member 10, like
chr21_-_27338639 1.37 ENSDART00000130632
hypoxia-inducible factor 1, alpha subunit, like 2
chr4_-_49607096 1.34 ENSDART00000154381
si:dkey-159n16.4
chr7_-_16597130 1.34 ENSDART00000144118
E2F transcription factor 8
chr20_+_4157815 1.32 ENSDART00000113132
glyceronephosphate O-acyltransferase
chr19_-_35400819 1.32 ENSDART00000148080
ring finger protein 19B
chr16_+_54829293 1.29 ENSDART00000024729
poly(A) binding protein, cytoplasmic 1a
chr6_-_43769332 1.27 ENSDART00000128174
forkhead box P1b
chr4_+_25680480 1.25 ENSDART00000100737
acyl-CoA thioesterase 17
chr9_-_22240052 1.12 ENSDART00000111109
crystallin, gamma M2d9
chr4_+_25706037 1.10 ENSDART00000141133
laminin, beta 1b
chr10_-_40479911 1.10 ENSDART00000136741
trace amine associated receptor 20d1
chr11_+_16137302 1.05 ENSDART00000164892
Pim proto-oncogene, serine/threonine kinase, related 204
chr11_-_8271374 1.02 ENSDART00000168253
Pim proto-oncogene, serine/threonine kinase, related 202
chr23_+_44263986 1.00 ENSDART00000149194
discs, large homolog 4b (Drosophila)
chr20_-_13673566 0.94 ENSDART00000181641
si:ch211-122h15.4
chr1_+_54773877 0.88 ENSDART00000129831
NLR family CARD domain containing 6
chr11_-_8208464 0.87 ENSDART00000161283
Pim proto-oncogene, serine/threonine kinase, related 203
chr8_-_45835056 0.82 ENSDART00000022242
oxoglutarate (alpha-ketoglutarate) dehydrogenase a (lipoamide)
chr13_-_36418921 0.81 ENSDART00000135804
ddb1 and cul4 associated factor 5
chr23_-_24047054 0.79 ENSDART00000184308
ENSDART00000185902

chr13_-_9300299 0.75 ENSDART00000144142
si:dkey-33c12.12
chr12_+_26608883 0.75 ENSDART00000153094
si:dkey-148d16.5
chr9_-_52847881 0.74 ENSDART00000166407
transient receptor potential cation channel, subfamily M, member 2
chr6_+_13046720 0.73 ENSDART00000165896
caspase 8, apoptosis-related cysteine peptidase
chr20_-_1314537 0.65 ENSDART00000144288
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr2_-_48539673 0.63 ENSDART00000168202

chr2_+_44528255 0.62 ENSDART00000193834
PAS domain containing serine/threonine kinase
chr23_+_42254960 0.59 ENSDART00000102980
zinc finger, CCHC domain containing 11
chr5_-_1999417 0.52 ENSDART00000155437
ENSDART00000145781
si:ch211-160e1.5
chr4_+_71018579 0.45 ENSDART00000186727
si:dkeyp-80d11.10
chr2_+_23352302 0.44 ENSDART00000187760
ring finger protein 2
chr8_+_52515188 0.42 ENSDART00000163668
si:ch1073-392o20.2
chr2_-_7185460 0.37 ENSDART00000092078
ring finger and CCCH-type domains 1b
chr18_+_44768829 0.29 ENSDART00000016271
ilvB (bacterial acetolactate synthase)-like
chr7_+_41314862 0.25 ENSDART00000185198
zgc:165532
chr25_+_4581214 0.21 ENSDART00000185552

chr22_+_12477996 0.18 ENSDART00000177704

chr8_+_22485956 0.10 ENSDART00000099960
si:ch211-261n11.7
chr17_+_49091661 0.08 ENSDART00000177166
ENSDART00000177390
ENSDART00000190114
T cell lymphoma invasion and metastasis 2a
chr8_-_34762163 0.05 ENSDART00000114080
SET domain containing 1B, b

Network of associatons between targets according to the STRING database.

First level regulatory network of tp73

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.8 GO:0033301 cell cycle comprising mitosis without cytokinesis(GO:0033301)
0.7 2.0 GO:0050787 response to mercury ion(GO:0046689) detoxification of mercury ion(GO:0050787)
0.6 3.0 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.6 2.4 GO:0042779 tRNA 3'-trailer cleavage(GO:0042779)
0.5 2.1 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.5 2.8 GO:0051703 social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
0.4 1.3 GO:1901503 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.3 1.7 GO:0071072 heat generation(GO:0031649) regulation of heat generation(GO:0031650) positive regulation of heat generation(GO:0031652) regulation of phospholipid biosynthetic process(GO:0071071) negative regulation of phospholipid biosynthetic process(GO:0071072)
0.3 1.0 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.3 1.5 GO:0007344 karyogamy(GO:0000741) pronuclear fusion(GO:0007344)
0.2 0.7 GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism(GO:0043903)
0.2 6.9 GO:0030199 collagen fibril organization(GO:0030199)
0.2 1.4 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.1 4.4 GO:0051014 actin filament severing(GO:0051014)
0.1 1.7 GO:0033198 response to ATP(GO:0033198)
0.1 3.9 GO:0019835 cytolysis(GO:0019835)
0.1 2.8 GO:0018149 peptide cross-linking(GO:0018149)
0.1 3.0 GO:0032836 glomerular basement membrane development(GO:0032836)
0.1 7.1 GO:0030318 melanocyte differentiation(GO:0030318)
0.1 2.7 GO:0061035 regulation of cartilage development(GO:0061035)
0.1 0.6 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.1 5.4 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.1 0.3 GO:0006549 isoleucine metabolic process(GO:0006549) isoleucine biosynthetic process(GO:0009097)
0.1 3.5 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.1 2.3 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.1 1.4 GO:0071456 cellular response to hypoxia(GO:0071456)
0.1 4.5 GO:0001666 response to hypoxia(GO:0001666)
0.1 6.5 GO:0070509 calcium ion import(GO:0070509)
0.0 1.1 GO:0070831 basement membrane assembly(GO:0070831)
0.0 3.8 GO:0017148 negative regulation of translation(GO:0017148)
0.0 2.9 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 1.3 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.0 0.8 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 3.3 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 1.7 GO:0006334 nucleosome assembly(GO:0006334)
0.0 2.5 GO:0007219 Notch signaling pathway(GO:0007219)
0.0 1.3 GO:0006417 regulation of translation(GO:0006417)
0.0 2.1 GO:0044782 cilium organization(GO:0044782)
0.0 2.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.5 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.2 3.9 GO:0005579 membrane attack complex(GO:0005579)
0.1 5.4 GO:0032040 small-subunit processome(GO:0032040)
0.1 0.3 GO:0005948 acetolactate synthase complex(GO:0005948)
0.1 6.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 6.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 1.7 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.1 0.8 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.1 3.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 4.4 GO:0001726 ruffle(GO:0001726)
0.1 4.9 GO:0005604 basement membrane(GO:0005604)
0.0 4.0 GO:0005882 intermediate filament(GO:0005882)
0.0 1.0 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.3 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.8 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 2.1 GO:0031514 motile cilium(GO:0031514)
0.0 2.8 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.4 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 2.1 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 1.5 GO:0031965 nuclear membrane(GO:0031965)
0.0 2.7 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 1.7 GO:0000786 nucleosome(GO:0000786)
0.0 0.4 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.5 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 15.7 GO:0005615 extracellular space(GO:0005615)
0.0 2.9 GO:0005911 cell-cell junction(GO:0005911)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0042781 3'-tRNA processing endoribonuclease activity(GO:0042781)
0.5 3.2 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.4 2.8 GO:0004962 endothelin receptor activity(GO:0004962)
0.4 2.8 GO:0001217 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.2 1.7 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.2 3.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.2 6.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.2 0.7 GO:0072570 ADP-D-ribose binding(GO:0072570) mono-ADP-D-ribose binding(GO:0072571)
0.2 2.7 GO:0070403 NAD+ binding(GO:0070403)
0.1 2.8 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 1.7 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 0.8 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 1.3 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 0.3 GO:0003984 acetolactate synthase activity(GO:0003984)
0.1 1.3 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 3.0 GO:0004629 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.1 3.1 GO:0005518 collagen binding(GO:0005518)
0.1 8.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 2.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 1.7 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 11.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 3.5 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 0.7 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.0 2.2 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 4.5 GO:0051082 unfolded protein binding(GO:0051082)
0.0 1.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.9 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.0 7.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.3 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 1.9 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 2.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.1 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 1.1 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 4.0 GO:0005198 structural molecule activity(GO:0005198)
0.0 2.0 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.0 4.4 GO:0051015 actin filament binding(GO:0051015)
0.0 3.3 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 5.9 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.8 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.1 3.0 PID RAS PATHWAY Regulation of Ras family activation
0.1 0.7 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 2.7 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 4.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 3.6 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.5 PID E2F PATHWAY E2F transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.5 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1 3.9 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.1 5.4 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 3.8 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 0.7 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 6.0 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 2.0 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.1 1.3 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 2.2 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway