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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for twist1a+twist1b+twist3

Z-value: 0.42

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Transcription factors associated with twist1a+twist1b+twist3

Gene Symbol Gene ID Gene Info
twist3
ENSDARG00000019646 twist3
twist1a
ENSDARG00000030402 twist family bHLH transcription factor 1a
twist1b
ENSDARG00000076010 twist family bHLH transcription factor 1b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
twist1bdr11_v1_chr16_+_19732543_19732543-0.171.1e-01Click!
twist1adr11_v1_chr19_-_2231146_22311880.065.8e-01Click!
twist3dr11_v1_chr23_+_2669_2669-0.065.9e-01Click!

Activity profile of twist1a+twist1b+twist3 motif

Sorted Z-values of twist1a+twist1b+twist3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_1412193 5.22 ENSDART00000064419
leg1.1
liver-enriched gene 1, tandem duplicate 1
chr4_-_17725008 3.95 ENSDART00000016658
chpt1
choline phosphotransferase 1
chr5_+_6670945 3.58 ENSDART00000185686
pxna
paxillin a
chr21_-_43666420 3.29 ENSDART00000139008
ENSDART00000183996
ENSDART00000183395
si:dkey-229d11.3
si:dkey-229d11.5
si:dkey-229d11.3
si:dkey-229d11.5
chr4_+_1530287 3.13 ENSDART00000067446
slc38a4
solute carrier family 38, member 4
chr23_-_44574059 3.00 ENSDART00000123007
si:ch73-160p18.3
si:ch73-160p18.3
chr3_-_1963126 2.80 ENSDART00000036445
si:ch211-254c8.3
si:ch211-254c8.3
chr3_+_49021079 2.70 ENSDART00000162012
zgc:163083
zgc:163083
chr5_-_32505109 1.94 ENSDART00000188219
ntmt1
N-terminal Xaa-Pro-Lys N-methyltransferase 1
chr18_+_45666489 1.72 ENSDART00000180147
ENSDART00000151351
prrg4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr5_-_15321451 1.58 ENSDART00000139203
txnrd2.1
thioredoxin reductase 2, tandem duplicate 1
chr21_-_5879897 1.55 ENSDART00000184034
rpl35
ribosomal protein L35
chr4_+_77973876 1.52 ENSDART00000057423
terfa
telomeric repeat binding factor a
chr13_-_12602920 1.44 ENSDART00000102311
lrit3b
leucine-rich repeat, immunoglobulin-like and transmembrane domains 3b
chr6_+_30456788 1.41 ENSDART00000121492
FP236735.1

chr5_-_26181863 1.38 ENSDART00000098500
ccdc125
coiled-coil domain containing 125
chr9_-_40014339 1.35 ENSDART00000166918
IKZF2
si:zfos-1425h8.1
chr15_-_1590858 1.31 ENSDART00000081875
nnr
nanor
chr3_+_59411956 1.25 ENSDART00000166982
sec14l1
SEC14-like lipid binding 1
chr5_-_23696926 1.25 ENSDART00000021462
rnf128a
ring finger protein 128a
chr13_+_35690023 1.21 ENSDART00000128865
ENSDART00000130050
psme4a
proteasome activator subunit 4a
chr5_-_72376973 1.16 ENSDART00000164969
CABZ01100198.1

chr6_+_103361 1.15 ENSDART00000151899
ldlrb
low density lipoprotein receptor b
chr21_-_35419486 1.13 ENSDART00000138529
si:dkeyp-23e4.3
si:dkeyp-23e4.3
chr20_-_2134620 1.10 ENSDART00000064375
tmem244
transmembrane protein 244
chr12_-_44180132 1.09 ENSDART00000165998
si:ch73-329n5.1
si:ch73-329n5.1
chr5_-_7829657 1.06 ENSDART00000158374
pdlim5a
PDZ and LIM domain 5a
chr5_-_11809404 1.04 ENSDART00000132564
nf2a
neurofibromin 2a (merlin)
chr1_+_45925365 0.96 ENSDART00000144245
eif5b
eukaryotic translation initiation factor 5B
chr11_+_25472758 0.95 ENSDART00000011178
opn1sw2
opsin 1 (cone pigments), short-wave-sensitive 2
chr10_+_40737540 0.89 ENSDART00000125577
taar19a
trace amine associated receptor 19a
chr2_-_49997055 0.88 ENSDART00000140294
si:ch211-106n13.3
si:ch211-106n13.3
chr23_-_36313431 0.88 ENSDART00000125860
nfe2
nuclear factor, erythroid 2
chr1_+_45925150 0.84 ENSDART00000074689
eif5b
eukaryotic translation initiation factor 5B
chr6_-_16981321 0.79 ENSDART00000154585
pimr29
Pim proto-oncogene, serine/threonine kinase, related 29
chr17_+_1360192 0.79 ENSDART00000184561
siva1
SIVA1, apoptosis-inducing factor
chr6_+_16982613 0.77 ENSDART00000156104
pimr8
Pim proto-oncogene, serine/threonine kinase, related 8
chr21_-_26520629 0.76 ENSDART00000142731
rce1b
Ras converting CAAX endopeptidase 1b
chr7_+_17485782 0.74 ENSDART00000098083
CU179759.1
Danio rerio novel immune-type receptor 1d (nitr1d), mRNA.
chr4_-_36476889 0.72 ENSDART00000163956
si:ch211-263l8.1
si:ch211-263l8.1
chr6_+_42693114 0.70 ENSDART00000154353
si:ch211-207d10.2
si:ch211-207d10.2
chr22_-_5752009 0.70 ENSDART00000190052
bcdin3d
BCDIN3 domain containing
chr7_+_4671483 0.68 ENSDART00000111390
si:ch211-225k7.6
si:ch211-225k7.6
chr14_+_46216703 0.65 ENSDART00000136045
ENSDART00000142317
mgst2
microsomal glutathione S-transferase 2
chr6_-_55423220 0.63 ENSDART00000158929
ctsa
cathepsin A
chr6_+_42693288 0.62 ENSDART00000155010
si:ch211-207d10.2
si:ch211-207d10.2
chr8_+_20140321 0.58 ENSDART00000012120
acsbg2
acyl-CoA synthetase bubblegum family member 2
chr18_+_33100606 0.58 ENSDART00000003907
si:ch211-229c8.13
si:ch211-229c8.13
chr13_+_25486608 0.58 ENSDART00000057689
bag3
BCL2 associated athanogene 3
chr6_-_10728057 0.56 ENSDART00000002247
sp3b
Sp3b transcription factor
chr25_+_25438322 0.55 ENSDART00000150364
LRRC56
si:ch211-103e16.5
chr7_-_9674073 0.52 ENSDART00000187902
lrrk1
leucine-rich repeat kinase 1
chr20_+_2134816 0.46 ENSDART00000039249
l3mbtl3
l(3)mbt-like 3 (Drosophila)
chr18_+_46773198 0.46 ENSDART00000174647
CABZ01041495.1

chr4_-_71177920 0.44 ENSDART00000158287
si:dkey-193i10.1
si:dkey-193i10.1
chr11_-_34232906 0.41 ENSDART00000162150
lsg1
large 60S subunit nuclear export GTPase 1
chr7_-_12596727 0.41 ENSDART00000186413
adamtsl3
ADAMTS-like 3
chr10_+_1052591 0.40 ENSDART00000123405
unc5c
unc-5 netrin receptor C
chr13_-_9119867 0.40 ENSDART00000137255
si:dkey-112g5.15
si:dkey-112g5.15
chr13_+_35689749 0.37 ENSDART00000158726
psme4a
proteasome activator subunit 4a
chr4_-_31700186 0.30 ENSDART00000183986
ENSDART00000180890
si:dkey-16p6.1
si:dkey-16p6.1
chr2_-_10896745 0.29 ENSDART00000114609
cdcp2
CUB domain containing protein 2
chr8_+_247163 0.27 ENSDART00000122378
cep120
centrosomal protein 120
chr17_-_40876680 0.27 ENSDART00000127200
supt7l
SPT7-like STAGA complex gamma subunit
chr8_-_34762163 0.27 ENSDART00000114080
setd1bb
SET domain containing 1B, b
chr8_-_14067517 0.23 ENSDART00000140948
dedd
death effector domain containing
chr4_-_75616197 0.20 ENSDART00000157778
si:dkey-71l4.3
si:dkey-71l4.3
chr16_-_19568795 0.18 ENSDART00000185141
abcb5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr16_-_31791165 0.13 ENSDART00000148389
chd4b
chromodomain helicase DNA binding protein 4b
chr20_+_36623807 0.13 ENSDART00000149171
ENSDART00000062895
srp9
signal recognition particle 9
chr14_-_31087830 0.10 ENSDART00000002250
hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr3_+_58472305 0.09 ENSDART00000154122
si:ch211-165g14.1
si:ch211-165g14.1
chr24_+_39660124 0.09 ENSDART00000066500
stub1
STIP1 homology and U-Box containing protein 1
chr24_-_25184553 0.00 ENSDART00000166917
plcxd2
phosphatidylinositol-specific phospholipase C, X domain containing 2

Network of associatons between targets according to the STRING database.

First level regulatory network of twist1a+twist1b+twist3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0006480 N-terminal protein amino acid methylation(GO:0006480)
0.5 5.2 GO:1990402 embryonic liver development(GO:1990402)
0.4 1.5 GO:0032207 regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208)
0.3 1.6 GO:0035092 spermatid nucleus differentiation(GO:0007289) sperm chromatin condensation(GO:0035092) spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.3 0.8 GO:0080120 CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
0.2 3.6 GO:0061055 myotome development(GO:0061055)
0.2 0.6 GO:0010662 negative regulation of muscle cell apoptotic process(GO:0010656) muscle cell apoptotic process(GO:0010657) striated muscle cell apoptotic process(GO:0010658) regulation of muscle cell apoptotic process(GO:0010660) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664)
0.2 0.7 GO:0070920 regulation of production of small RNA involved in gene silencing by RNA(GO:0070920) regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903798)
0.1 0.6 GO:0006691 leukotriene metabolic process(GO:0006691) leukotriene biosynthetic process(GO:0019370)
0.1 1.4 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.1 1.5 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.1 0.9 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.1 0.3 GO:0010825 positive regulation of centrosome duplication(GO:0010825)
0.1 0.2 GO:0046689 response to mercury ion(GO:0046689) detoxification of mercury ion(GO:0050787)
0.1 1.6 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 3.1 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.4 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 4.0 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.0 0.6 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.0 0.4 GO:0033753 ribosomal subunit export from nucleus(GO:0000054) ribosome localization(GO:0033750) establishment of ribosome localization(GO:0033753) rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428)
0.0 1.0 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 1.8 GO:0006413 translational initiation(GO:0006413)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 1.0 GO:0097191 extrinsic apoptotic signaling pathway(GO:0097191)
0.0 1.1 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.3 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 1.5 GO:0070187 telosome(GO:0070187)
0.0 0.3 GO:0030914 STAGA complex(GO:0030914)
0.0 3.6 GO:0005925 focal adhesion(GO:0005925)
0.0 1.1 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.4 GO:0015030 Cajal body(GO:0015030)
0.0 1.0 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.1 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0 0.3 GO:0048188 Set1C/COMPASS complex(GO:0048188)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.0 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.6 1.9 GO:0071885 N-terminal protein N-methyltransferase activity(GO:0071885)
0.2 1.5 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.2 1.6 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.2 0.6 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.2 1.6 GO:0016504 peptidase activator activity(GO:0016504)
0.1 0.6 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 0.6 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 1.1 GO:0051371 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.0 0.6 GO:0016405 CoA-ligase activity(GO:0016405)
0.0 0.4 GO:0005042 netrin receptor activity(GO:0005042)
0.0 3.1 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 0.7 GO:0008171 O-methyltransferase activity(GO:0008171)
0.0 1.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 1.0 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.1 GO:0008312 7S RNA binding(GO:0008312)
0.0 0.1 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.0 0.8 GO:0032813 tumor necrosis factor receptor superfamily binding(GO:0032813)
0.0 0.9 GO:0001594 trace-amine receptor activity(GO:0001594)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID NETRIN PATHWAY Netrin-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.0 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 3.1 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 3.5 REACTOME TRANSLATION Genes involved in Translation
0.0 0.6 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.4 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling