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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for zbtb12.2

Z-value: 0.59

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Transcription factors associated with zbtb12.2

Gene Symbol Gene ID Gene Info
zbtb12.2
ENSDARG00000070658 zinc finger and BTB domain containing 12, tandem duplicate 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
zbtb12.2dr11_v1_chr19_-_26964348_269643480.372.0e-04Click!

Activity profile of zbtb12.2 motif

Sorted Z-values of zbtb12.2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr23_-_26522760 5.98 ENSDART00000142417
ENSDART00000135606
ENSDART00000122668
si:dkey-205h13.1
si:dkey-205h13.1
chr24_-_28259127 5.54 ENSDART00000149589
prkag2a
protein kinase, AMP-activated, gamma 2 non-catalytic subunit a
chr23_-_26521970 4.91 ENSDART00000143712
si:dkey-205h13.1
si:dkey-205h13.1
chr17_+_53425037 3.16 ENSDART00000154983
fabp10b
fatty acid binding protein 10b, liver basic
chr21_-_13672195 2.84 ENSDART00000146717
clic3
chloride intracellular channel 3
chr5_+_25311309 2.63 ENSDART00000169638
wu:fa19b12
wu:fa19b12
chr10_-_15048781 2.41 ENSDART00000038401
ENSDART00000155674
si:ch211-95j8.2
si:ch211-95j8.2
chr12_-_26430507 2.35 ENSDART00000153214
synpo2lb
synaptopodin 2-like b
chr3_-_2033105 2.25 ENSDART00000135249
si:dkey-88j15.3
si:dkey-88j15.3
chr13_-_45475289 2.24 ENSDART00000043345
rsrp1
arginine/serine-rich protein 1
chr17_+_53424415 1.79 ENSDART00000157022
slc9a1b
solute carrier family 9 member A1b
chr20_-_29532939 1.75 ENSDART00000049224
ENSDART00000062377
taf1b
TATA box binding protein (Tbp)-associated factor, RNA polymerase I, B
chr16_+_53526135 1.72 ENSDART00000083558
smpd5
sphingomyelin phosphodiesterase 5
chr6_-_54126463 1.62 ENSDART00000161059
tusc2a
tumor suppressor candidate 2a
chr7_-_38659477 1.59 ENSDART00000138071
npsn
nephrosin
chr3_-_31784082 1.49 ENSDART00000134201
kcnh6a
potassium voltage-gated channel, subfamily H (eag-related), member 6a
chr18_+_8402129 1.38 ENSDART00000081154
ENSDART00000171974
prpf18
PRP18 pre-mRNA processing factor 18 homolog (yeast)
chr2_+_22602301 1.37 ENSDART00000038514
sept2
septin 2
chr3_-_31783737 1.36 ENSDART00000090809
kcnh6a
potassium voltage-gated channel, subfamily H (eag-related), member 6a
chr20_-_44496245 1.35 ENSDART00000012229
fkbp1b
FK506 binding protein 1b
chr10_+_29849497 1.23 ENSDART00000099994
ENSDART00000132212
hspa8
heat shock protein 8
chr24_+_42148140 1.17 ENSDART00000010658
serpinb1l3
serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 3
chr19_+_20793388 1.15 ENSDART00000142463
txnl4a
thioredoxin-like 4A
chr6_-_2154137 1.15 ENSDART00000162656
tgm5l
transglutaminase 5, like
chr16_-_46619967 1.12 ENSDART00000158341
tmem176l.3a
transmembrane protein 176l.3a
chr19_+_20793237 1.12 ENSDART00000014774
txnl4a
thioredoxin-like 4A
chr22_+_2239974 1.11 ENSDART00000141993
znf1144
zinc finger protein 1144
chr22_+_9862243 1.10 ENSDART00000105942
si:dkey-253d23.3
si:dkey-253d23.3
chr11_-_18254 1.10 ENSDART00000167814
prr13
proline rich 13
chr11_-_18449 1.09 ENSDART00000172050
prr13
proline rich 13
chr3_-_61345723 1.01 ENSDART00000156749
si:dkey-111k8.5
si:dkey-111k8.5
chr6_-_22369125 0.99 ENSDART00000083038
nprl2
NPR2 like, GATOR1 complex subunit
chr19_-_24136233 0.98 ENSDART00000143365
thap7
THAP domain containing 7
chr21_-_28737320 0.97 ENSDART00000098696
ENSDART00000124826
ENSDART00000125652
nrg2a
neuregulin 2a
chr5_-_29570141 0.94 ENSDART00000043259
entpd2a.2
ectonucleoside triphosphate diphosphohydrolase 2a, tandem duplicate 2
chr1_+_218524 0.94 ENSDART00000109529
tmco3
transmembrane and coiled-coil domains 3
chr14_+_46342882 0.86 ENSDART00000193707
ENSDART00000060577
tmem33
transmembrane protein 33
chr19_+_8985230 0.86 ENSDART00000018973
scamp3
secretory carrier membrane protein 3
chr6_+_20954400 0.85 ENSDART00000143248
ENSDART00000165806
stk11ip
serine/threonine kinase 11 interacting protein
chr16_-_48430272 0.83 ENSDART00000005927
rad21a
RAD21 cohesin complex component a
chr8_+_24281512 0.82 ENSDART00000062845
mmp9
matrix metallopeptidase 9
chr20_+_9355912 0.80 ENSDART00000142337
si:dkey-174m14.3
si:dkey-174m14.3
chr6_-_24392426 0.80 ENSDART00000163965
brdt
bromodomain, testis-specific
chr16_+_25989943 0.80 ENSDART00000149113
si:ch73-103b2.1
si:ch73-103b2.1
chr3_-_61354239 0.77 ENSDART00000154312
znf1134
zinc finger protein 1134
chr3_+_62339264 0.76 ENSDART00000174569
BX470259.3

chr22_+_2686673 0.75 ENSDART00000161580
si:dkey-20i20.15
si:dkey-20i20.15
chr15_+_38299563 0.74 ENSDART00000099375
si:dkey-24p1.6
si:dkey-24p1.6
chr3_+_43374571 0.68 ENSDART00000182497
zfand2a
zinc finger, AN1-type domain 2A
chr6_+_12482599 0.68 ENSDART00000090316
stk24b
serine/threonine kinase 24b (STE20 homolog, yeast)
chr17_-_32865788 0.67 ENSDART00000077476
prox1a
prospero homeobox 1a
chr19_+_26640096 0.66 ENSDART00000067793
ints3
integrator complex subunit 3
chr7_+_29024282 0.65 ENSDART00000076425
cog4
component of oligomeric golgi complex 4
chr19_+_3215466 0.65 ENSDART00000181288
zgc:86598
zgc:86598
chr1_+_16127825 0.63 ENSDART00000122503
tusc3
tumor suppressor candidate 3
chr12_+_9849476 0.62 ENSDART00000110458
fam117ab
family with sequence similarity 117, member Ab
chr6_+_11397269 0.61 ENSDART00000114260
senp2
SUMO1/sentrin/SMT3 specific peptidase 2
chr22_+_1540849 0.58 ENSDART00000192088
si:ch211-255f4.7
si:ch211-255f4.7
chr22_+_1734981 0.57 ENSDART00000158195
znf1159
zinc finger protein 1159
chr13_-_4223955 0.56 ENSDART00000113060
dnph1
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
chr21_-_43171249 0.54 ENSDART00000021037
ENSDART00000148630
hspa4a
heat shock protein 4a
chr5_-_66823750 0.51 ENSDART00000041441
ENSDART00000112488
stip1
stress-induced phosphoprotein 1
chr21_+_1587722 0.49 ENSDART00000013581
wdr91
WD repeat domain 91
chr22_+_1837448 0.48 ENSDART00000160015
znf1183
zinc finger protein 1183
chr19_-_25519310 0.48 ENSDART00000089882
C1GALT1 (1 of many)
si:dkey-202e17.1
chr21_+_20386865 0.47 ENSDART00000144366
si:dkey-30k6.5
si:dkey-30k6.5
chr3_-_36364903 0.47 ENSDART00000028883
gna13b
guanine nucleotide binding protein (G protein), alpha 13b
chr16_+_38659475 0.47 ENSDART00000023238
emc2
ER membrane protein complex subunit 2
chr19_+_3140313 0.46 ENSDART00000125504
zgc:86598
zgc:86598
chr21_+_43171013 0.45 ENSDART00000151362
zcchc10
zinc finger, CCHC domain containing 10
chr19_-_25519612 0.44 ENSDART00000133150
C1GALT1 (1 of many)
si:dkey-202e17.1
chr3_+_43373867 0.42 ENSDART00000159455
ENSDART00000172425
zfand2a
zinc finger, AN1-type domain 2A
chr5_+_31944270 0.36 ENSDART00000147850
ungb
uracil DNA glycosylase b
chr17_-_12249990 0.36 ENSDART00000177889
ENSDART00000155545
ahctf1
AT hook containing transcription factor 1
chr16_-_42175617 0.36 ENSDART00000084715
alkbh8
alkB homolog 8, tRNA methyltransferase
chr3_-_15645405 0.36 ENSDART00000133957
si:dkey-93n13.1
si:dkey-93n13.1
chr7_-_60156409 0.35 ENSDART00000006802
cct7
chaperonin containing TCP1, subunit 7 (eta)
chr1_-_59021796 0.34 ENSDART00000168314
zgc:153247
zgc:153247
chr5_-_42950963 0.32 ENSDART00000149868
grsf1
G-rich RNA sequence binding factor 1
chr7_+_34297271 0.32 ENSDART00000180342
bbox1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr22_-_14475927 0.32 ENSDART00000135768
lrp1ba
low density lipoprotein receptor-related protein 1Ba
chr1_+_54194801 0.31 ENSDART00000186802
CABZ01067150.1

chr2_-_20981907 0.30 ENSDART00000113384
lyrm4
LYR motif containing 4
chr22_+_2144278 0.30 ENSDART00000162173
ENSDART00000159914
ENSDART00000160192
znf1164
zinc finger protein 1164
chr13_+_23623346 0.27 ENSDART00000057619
il22ra2
interleukin 22 receptor, alpha 2
chr16_-_10837245 0.27 ENSDART00000036891
rabac1
Rab acceptor 1 (prenylated)
chr23_+_34005792 0.25 ENSDART00000132668
si:ch211-207e14.4
si:ch211-207e14.4
chr7_+_59649399 0.23 ENSDART00000123520
ENSDART00000040771
rpl34
ribosomal protein L34
chr22_+_1300587 0.21 ENSDART00000124161
si:ch73-138e16.5
si:ch73-138e16.5
chr17_-_50436199 0.21 ENSDART00000156494
si:ch211-235i11.6
si:ch211-235i11.6
chr17_-_50454957 0.19 ENSDART00000171616
ENSDART00000075195
si:ch211-235i11.7
si:ch211-235i11.7
chr22_+_2512154 0.18 ENSDART00000097363
zgc:173726
zgc:173726
chr22_+_9287929 0.14 ENSDART00000193522
si:ch211-250k18.7
si:ch211-250k18.7
chr22_+_2048566 0.13 ENSDART00000169234
si:dkey-1b17.9
si:dkey-1b17.9
chr24_-_7957581 0.12 ENSDART00000145815
txndc5
thioredoxin domain containing 5
chr10_-_17284055 0.11 ENSDART00000167464
GNAZ
G protein subunit alpha z
chr22_+_9239831 0.11 ENSDART00000133720
si:ch211-250k18.5
si:ch211-250k18.5
chr7_+_21768452 0.10 ENSDART00000127719
kdm6ba
lysine (K)-specific demethylase 6B, a
chr20_-_38449903 0.10 ENSDART00000136303
itpkb
inositol-trisphosphate 3-kinase B
chr4_+_20085114 0.09 ENSDART00000186698
ENSDART00000188635
ppp6r2a
protein phosphatase 6, regulatory subunit 2a
chr16_-_45398408 0.09 ENSDART00000004052
rgl2
ral guanine nucleotide dissociation stimulator-like 2
chr18_+_28106139 0.09 ENSDART00000089615
kiaa1549lb
KIAA1549-like b
chr3_-_136043 0.09 ENSDART00000160266
zgc:110249
zgc:110249
chr23_-_38054 0.07 ENSDART00000170393
CABZ01074076.1

chr3_-_7129057 0.07 ENSDART00000125947
BX005085.1

chr9_-_180334 0.03 ENSDART00000180339
zgc:158619
zgc:158619
chr1_+_32521469 0.02 ENSDART00000113818
ENSDART00000152580
nlgn4a
neuroligin 4a
chr1_-_40341306 0.02 ENSDART00000190649
maml3
mastermind-like transcriptional coactivator 3
chr22_+_9862466 0.00 ENSDART00000146864
si:dkey-253d23.3
si:dkey-253d23.3

Network of associatons between targets according to the STRING database.

First level regulatory network of zbtb12.2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.8 GO:0099623 regulation of membrane repolarization(GO:0060306) regulation of ventricular cardiac muscle cell membrane repolarization(GO:0060307) regulation of cardiac muscle cell membrane repolarization(GO:0099623) ventricular cardiac muscle cell membrane repolarization(GO:0099625)
0.5 1.4 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.3 1.7 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.3 1.6 GO:0051881 regulation of mitochondrial membrane potential(GO:0051881)
0.3 0.8 GO:0002676 granuloma formation(GO:0002432) chronic inflammatory response(GO:0002544) regulation of granuloma formation(GO:0002631) regulation of chronic inflammatory response(GO:0002676)
0.3 0.8 GO:0001207 histone displacement(GO:0001207) regulation of transcription involved in meiotic cell cycle(GO:0051037) positive regulation of transcription involved in meiotic cell cycle(GO:0051039)
0.2 1.2 GO:1902946 positive regulation of receptor-mediated endocytosis(GO:0048260) protein localization to early endosome(GO:1902946)
0.2 0.6 GO:0009162 deoxyribonucleoside monophosphate metabolic process(GO:0009162)
0.2 1.7 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.2 0.8 GO:0003173 ventriculo bulbo valve development(GO:0003173)
0.2 1.8 GO:0097369 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.2 0.9 GO:0071405 response to methanol(GO:0033986) cellular response to methanol(GO:0071405)
0.1 5.5 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 1.0 GO:0060347 ventricular trabecula myocardium morphogenesis(GO:0003222) trabecula formation(GO:0060343) heart trabecula formation(GO:0060347) skin epidermis development(GO:0098773)
0.1 0.5 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.1 0.9 GO:1901339 regulation of store-operated calcium channel activity(GO:1901339)
0.1 2.3 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.1 10.9 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.1 0.4 GO:0097510 base-excision repair, AP site formation via deaminated base removal(GO:0097510)
0.1 0.4 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.1 0.5 GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence(GO:0045050)
0.1 1.0 GO:2000785 regulation of autophagosome assembly(GO:2000785)
0.1 1.2 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.8 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.0 0.3 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 1.3 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.6 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.5 GO:0043550 regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 0.6 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.7 GO:0044818 mitotic G2/M transition checkpoint(GO:0044818)
0.0 0.1 GO:0061384 trabecula morphogenesis(GO:0061383) heart trabecula morphogenesis(GO:0061384)
0.0 0.7 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.0 2.8 GO:0006821 chloride transport(GO:0006821)
0.0 1.1 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 0.4 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 0.7 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.3 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.5 5.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.2 3.6 GO:0005682 U5 snRNP(GO:0005682)
0.1 1.0 GO:1990130 Iml1 complex(GO:1990130)
0.1 0.8 GO:0000798 nuclear cohesin complex(GO:0000798) mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990) nuclear meiotic cohesin complex(GO:0034991)
0.1 0.7 GO:0070876 SOSS complex(GO:0070876)
0.1 1.1 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.1 0.5 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 1.4 GO:0060170 ciliary membrane(GO:0060170)
0.1 0.5 GO:0031526 brush border membrane(GO:0031526)
0.1 0.7 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.6 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 2.8 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.5 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 1.7 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 0.3 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 2.3 GO:0030018 Z disc(GO:0030018)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0001163 RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.4 10.9 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.2 5.5 GO:0016208 AMP binding(GO:0016208)
0.2 1.8 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.2 0.5 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.1 1.7 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 0.4 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.1 0.3 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.1 1.2 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 0.9 GO:0015299 solute:proton antiporter activity(GO:0015299)
0.1 0.8 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 1.2 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 0.9 GO:0045134 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.1 0.5 GO:0032977 membrane insertase activity(GO:0032977)
0.0 0.6 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 0.9 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
0.0 0.5 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 2.8 GO:0005254 chloride channel activity(GO:0005254)
0.0 1.3 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.2 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 2.8 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 2.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.5 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0 0.1 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.6 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.9 PID LKB1 PATHWAY LKB1 signaling events
0.0 1.4 PID CDC42 PATHWAY CDC42 signaling events
0.0 1.2 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.1 PID S1P S1P4 PATHWAY S1P4 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 1.2 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 1.7 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.1 2.3 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.3 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC