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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for zbtb3

Z-value: 1.06

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Transcription factors associated with zbtb3

Gene Symbol Gene ID Gene Info
zbtb3
ENSDARG00000036235 zinc finger and BTB domain containing 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
zbtb3dr11_v1_chr14_+_35405518_35405518-0.251.5e-02Click!

Activity profile of zbtb3 motif

Sorted Z-values of zbtb3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_52398205 123.68 ENSDART00000143225
si:ch211-217k17.9
si:ch211-217k17.9
chr3_-_61185746 16.11 ENSDART00000028219
pvalb4
parvalbumin 4
chr16_-_42872571 12.68 ENSDART00000154757
ENSDART00000102345
txnipb
thioredoxin interacting protein b
chr2_+_68789 10.27 ENSDART00000058569
cldn1
claudin 1
chr15_-_2640966 9.19 ENSDART00000063320
cldne
claudin e
chr11_+_10548171 8.39 ENSDART00000191497
b3gnt5a
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5a
chr9_+_307863 7.53 ENSDART00000163474
stac3
SH3 and cysteine rich domain 3
chr4_-_13502549 5.76 ENSDART00000140366
si:ch211-266a5.12
si:ch211-266a5.12
chr20_+_25340814 5.74 ENSDART00000063028
ctgfa
connective tissue growth factor a
chr4_+_38550788 4.53 ENSDART00000157412
si:ch211-209n20.1
si:ch211-209n20.1
chr13_-_2215213 4.42 ENSDART00000129773
mlip
muscular LMNA-interacting protein
chr19_+_7878122 4.39 ENSDART00000131917
si:dkeyp-85e10.2
si:dkeyp-85e10.2
chr24_+_6107901 4.35 ENSDART00000156419
si:ch211-37e10.2
si:ch211-37e10.2
chr2_-_985417 4.32 ENSDART00000140540
si:ch211-241e1.3
si:ch211-241e1.3
chr19_+_917852 4.21 ENSDART00000082466
tgfbr2a
transforming growth factor beta receptor 2a
chr7_-_35432901 4.16 ENSDART00000026712
mmp2
matrix metallopeptidase 2
chr12_+_48220584 4.04 ENSDART00000164392
lrrc20
leucine rich repeat containing 20
chr6_+_7507390 3.96 ENSDART00000149285
erbb3a
erb-b2 receptor tyrosine kinase 3a
chr17_-_868004 3.76 ENSDART00000112803
wdr20a
WD repeat domain 20a
chr25_-_33275666 3.62 ENSDART00000193605
CABZ01046954.1

chr7_+_6879534 3.51 ENSDART00000157731
zgc:175248
zgc:175248
chr25_+_25453221 2.98 ENSDART00000176822
rassf7a
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7a
chr19_-_48010490 2.92 ENSDART00000159938
FBXL19
zgc:158376
chr1_+_58079053 2.90 ENSDART00000141678
si:ch211-114l13.3
si:ch211-114l13.3
chr4_+_12966640 2.84 ENSDART00000113357
vhll
von Hippel-Lindau tumor suppressor like
chr21_-_34951265 2.84 ENSDART00000135222
lipia
lipase, member Ia
chr16_-_32013913 2.77 ENSDART00000030282
ENSDART00000138701
gstk1
glutathione S-transferase kappa 1
chr3_+_49397115 2.70 ENSDART00000176042
tecra
trans-2,3-enoyl-CoA reductase a
chr6_-_39006449 2.63 ENSDART00000150885
vdrb
vitamin D receptor b
chr18_-_50839033 2.60 ENSDART00000169773
ddb1
damage-specific DNA binding protein 1
chr14_-_1355544 2.55 ENSDART00000060417
cetn4
centrin 4
chr3_-_34069637 2.47 ENSDART00000151588
ighv9-1
immunoglobulin heavy variable 9-1
chr3_-_3019979 2.44 ENSDART00000111174
zgc:172090
zgc:172090
chr2_+_25198648 2.40 ENSDART00000110922
ppp2r3a
protein phosphatase 2, regulatory subunit B'', alpha
chr17_+_52524452 2.38 ENSDART00000016614
dlst
dihydrolipoamide S-succinyltransferase
chr4_-_68913650 2.29 ENSDART00000184297
si:dkey-264f17.5
si:dkey-264f17.5
chr8_+_54135642 2.20 ENSDART00000170712
brpf1
bromodomain and PHD finger containing, 1
chr3_-_5353442 2.17 ENSDART00000188808
trim35-7
tripartite motif containing 35-7
chr11_-_42230491 2.00 ENSDART00000164423
CABZ01030862.1

chr23_-_7674902 1.93 ENSDART00000185612
ENSDART00000180524
plagl2
pleiomorphic adenoma gene-like 2
chr1_-_54425791 1.93 ENSDART00000039911
pkd1a
polycystic kidney disease 1a
chr24_-_26383978 1.90 ENSDART00000031426
skilb
SKI-like proto-oncogene b
chr9_+_48088031 1.77 ENSDART00000073870
si:ch73-54b5.2
si:ch73-54b5.2
chr15_-_19705707 1.77 ENSDART00000047643
sytl2b
synaptotagmin-like 2b
chr2_+_47718605 1.66 ENSDART00000189180
ENSDART00000148824
mbnl1
muscleblind-like splicing regulator 1
chr1_+_59007536 1.66 ENSDART00000165339
CDC37
cell division cycle 37
chr1_-_633356 1.54 ENSDART00000171019
appa
amyloid beta (A4) precursor protein a
chr8_-_1884955 1.47 ENSDART00000081563
si:dkey-178e17.3
si:dkey-178e17.3
chr7_-_26270014 1.47 ENSDART00000079347
serpine1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chr3_+_61185660 1.30 ENSDART00000167114
CR352263.1

chr6_+_12527725 1.26 ENSDART00000149328
stk24b
serine/threonine kinase 24b (STE20 homolog, yeast)
chr10_+_31951338 1.24 ENSDART00000019416
lhfpl6
LHFPL tetraspan subfamily member 6
chr8_+_22404981 1.17 ENSDART00000185211
ENSDART00000099972
si:dkey-23c22.7
si:dkey-23c22.9
si:dkey-23c22.7
si:dkey-23c22.9
chr18_+_37015185 1.16 ENSDART00000191305
sipa1l3
signal-induced proliferation-associated 1 like 3
chr19_-_35439237 1.15 ENSDART00000145883
anln
anillin, actin binding protein
chr1_+_532766 1.08 ENSDART00000179731
ENSDART00000060944
mrpl39
mitochondrial ribosomal protein L39
chr16_+_10422836 1.06 ENSDART00000161568
ino80e
INO80 complex subunit E
chr19_-_5264517 1.05 ENSDART00000001821
prf1.3
perforin 1.3
chr8_-_8446668 1.04 ENSDART00000132700
cdk16
cyclin-dependent kinase 16
chr8_+_26293673 1.02 ENSDART00000144977
mgll
monoglyceride lipase
chr21_+_35296246 1.01 ENSDART00000076750
il12bb
interleukin 12B, b
chr7_+_30051880 1.00 ENSDART00000075609
pstpip1b
proline-serine-threonine phosphatase interacting protein 1b
chr1_+_9153141 1.00 ENSDART00000081343
plk1
polo-like kinase 1 (Drosophila)
chr20_+_27713210 0.99 ENSDART00000132222
zbtb1
zinc finger and BTB domain containing 1
chr3_+_53240562 0.87 ENSDART00000031234
stxbp2
syntaxin binding protein 2
chr7_+_24522308 0.85 ENSDART00000173542
btr09
bloodthirsty-related gene family, member 9
chr2_-_27329214 0.72 ENSDART00000145835
tmx3a
thioredoxin related transmembrane protein 3a
chr8_+_30921403 0.70 ENSDART00000043251
derl3
derlin 3
chr7_+_24523017 0.64 ENSDART00000077047
btr09
bloodthirsty-related gene family, member 9
chr12_+_48683208 0.61 ENSDART00000188582
mmp21
matrix metallopeptidase 21
chr18_+_33521609 0.60 ENSDART00000147592
v2rh7
vomeronasal 2 receptor, h7
chr7_-_25895189 0.60 ENSDART00000173599
ENSDART00000079235
ENSDART00000173786
ENSDART00000173602
ENSDART00000079245
ENSDART00000187568
ENSDART00000173505
cd99l2
CD99 molecule-like 2
chr13_+_30035253 0.59 ENSDART00000181303
ENSDART00000057525
ENSDART00000136622
dnajb12a
DnaJ (Hsp40) homolog, subfamily B, member 12a
chr19_-_19442983 0.55 ENSDART00000052649
sb:cb649
sb:cb649
chr16_-_30969294 0.53 ENSDART00000147890
dgat1b
diacylglycerol O-acyltransferase 1b
chr11_+_1805421 0.53 ENSDART00000173143
lrp1aa
low density lipoprotein receptor-related protein 1Aa
chr8_-_53488832 0.47 ENSDART00000191801
chdh
choline dehydrogenase
chr14_+_24845941 0.46 ENSDART00000187513
arhgef37
Rho guanine nucleotide exchange factor (GEF) 37
chr24_+_21720304 0.42 ENSDART00000147250
ENSDART00000048273
pan3
PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr17_+_34215886 0.37 ENSDART00000186775
mpp5a
membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5)
chr3_+_8826905 0.35 ENSDART00000167474
ENSDART00000168088
si:dkeyp-30d6.2
si:dkeyp-30d6.2
chr9_-_27738110 0.30 ENSDART00000060347
crygs2
crystallin, gamma S2
chr7_-_34225011 0.27 ENSDART00000049588
crybgx
crystallin beta gamma X
chr9_-_28274932 0.27 ENSDART00000137582
ENSDART00000146932
creb1b
cAMP responsive element binding protein 1b
chr14_+_24934736 0.27 ENSDART00000191821
ppargc1b
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr1_-_22687913 0.25 ENSDART00000168171
fgfbp2b
fibroblast growth factor binding protein 2b
chr6_-_51556308 0.22 ENSDART00000149033
rbl1
retinoblastoma-like 1 (p107)
chr20_+_39375280 0.18 ENSDART00000172434
pimr131
Pim proto-oncogene, serine/threonine kinase, related 131
chr17_-_29311835 0.17 ENSDART00000104224
tecpr2
tectonin beta-propeller repeat containing 2
chr24_+_12740848 0.14 ENSDART00000060825
si:ch211-196f5.2
si:ch211-196f5.2
chr22_-_5051689 0.13 ENSDART00000113521
matk
megakaryocyte-associated tyrosine kinase
chr7_+_39079071 0.10 ENSDART00000181845
dgkza
diacylglycerol kinase, zeta a
chr23_-_29878643 0.10 ENSDART00000058407
slc25a33
solute carrier family 25 (pyrimidine nucleotide carrier), member 33
chr16_-_39131666 0.09 ENSDART00000075517
gdf6a
growth differentiation factor 6a
chr22_-_18387059 0.08 ENSDART00000007769
tssk6
testis-specific serine kinase 6
chr17_+_30450163 0.07 ENSDART00000104257
lpin1
lipin 1
chr5_+_9297585 0.04 ENSDART00000170557
si:ch73-194c23.1
si:ch73-194c23.1

Network of associatons between targets according to the STRING database.

First level regulatory network of zbtb3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 7.5 GO:1901387 positive regulation of voltage-gated calcium channel activity(GO:1901387)
0.8 2.4 GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.5 1.5 GO:0010755 regulation of plasminogen activation(GO:0010755)
0.5 1.9 GO:0044246 regulation of collagen metabolic process(GO:0010712) regulation of collagen biosynthetic process(GO:0032965) regulation of multicellular organismal metabolic process(GO:0044246)
0.4 2.5 GO:0021846 cell proliferation in forebrain(GO:0021846)
0.3 16.8 GO:0070830 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.3 1.2 GO:0008356 asymmetric cell division(GO:0008356)
0.2 4.2 GO:0035701 hematopoietic stem cell migration(GO:0035701)
0.2 0.7 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
0.2 2.8 GO:0019433 triglyceride catabolic process(GO:0019433)
0.2 2.2 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.2 0.5 GO:0019695 choline metabolic process(GO:0019695)
0.1 1.2 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 1.0 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 2.7 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.1 1.9 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.1 0.8 GO:2000406 positive regulation of lymphocyte migration(GO:2000403) positive regulation of T cell migration(GO:2000406)
0.1 4.2 GO:0071559 transforming growth factor beta receptor signaling pathway(GO:0007179) response to transforming growth factor beta(GO:0071559) cellular response to transforming growth factor beta stimulus(GO:0071560)
0.1 4.3 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 2.6 GO:0003146 heart jogging(GO:0003146)
0.0 2.2 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 1.1 GO:0019835 cytolysis(GO:0019835)
0.0 2.4 GO:0045214 sarcomere organization(GO:0045214)
0.0 0.1 GO:1990519 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.0 0.6 GO:0051788 response to misfolded protein(GO:0051788) cellular response to misfolded protein(GO:0071218)
0.0 7.6 GO:0043413 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
0.0 0.1 GO:0060220 retinal cone cell fate determination(GO:0042671) eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate determination(GO:0043703) retinal cone cell fate commitment(GO:0046551) photoreceptor cell fate commitment(GO:0046552) camera-type eye photoreceptor cell fate commitment(GO:0060220)
0.0 1.0 GO:0032465 regulation of cytokinesis(GO:0032465)
0.0 0.9 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.6 GO:0030574 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.0 0.6 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.0 0.7 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.0 2.7 GO:0008284 positive regulation of cell proliferation(GO:0008284)
0.0 1.5 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 0.4 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.2 GO:2000134 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 7.6 GO:0016567 protein ubiquitination(GO:0016567)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.8 GO:0030891 VCB complex(GO:0030891)
0.4 5.8 GO:0030315 T-tubule(GO:0030315)
0.3 1.0 GO:0070743 interleukin-12 complex(GO:0043514) interleukin-23 complex(GO:0070743)
0.2 2.4 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.2 4.0 GO:0009925 basal plasma membrane(GO:0009925)
0.2 1.2 GO:0005826 actomyosin contractile ring(GO:0005826)
0.1 0.4 GO:0031251 PAN complex(GO:0031251)
0.1 0.7 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 16.8 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.1 2.2 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1 4.4 GO:0016605 PML body(GO:0016605)
0.1 2.6 GO:0035861 site of double-strand break(GO:0035861)
0.1 2.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 1.1 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 4.3 GO:0005604 basement membrane(GO:0005604)
0.0 2.2 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 4.2 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 2.5 GO:0005814 centriole(GO:0005814)
0.0 2.8 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 4.2 GO:0030017 sarcomere(GO:0030017)
0.0 0.3 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.0 8.4 GO:0000139 Golgi membrane(GO:0000139)
0.0 1.0 GO:0000922 spindle pole(GO:0000922)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 8.4 GO:0008457 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
1.1 4.4 GO:0005521 lamin binding(GO:0005521)
0.8 2.4 GO:0016748 succinyltransferase activity(GO:0016748)
0.8 4.0 GO:0038131 neuregulin receptor activity(GO:0038131) neuregulin binding(GO:0038132)
0.7 4.2 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.5 2.6 GO:0070644 vitamin D response element binding(GO:0070644)
0.3 2.8 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.3 1.0 GO:0019972 interleukin-12 binding(GO:0019972) interleukin-12 alpha subunit binding(GO:0042164)
0.2 0.7 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.2 12.7 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.2 2.2 GO:0010484 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.1 0.7 GO:0016972 thiol oxidase activity(GO:0016972)
0.1 2.8 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.1 1.0 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 0.5 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.1 1.8 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 2.2 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.6 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.1 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.0 1.9 GO:0046332 SMAD binding(GO:0046332)
0.0 0.4 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 3.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 16.6 GO:0005198 structural molecule activity(GO:0005198)
0.0 2.4 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.9 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.2 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 18.7 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.3 GO:0035497 cAMP response element binding(GO:0035497)
0.0 1.9 GO:0005262 calcium channel activity(GO:0005262)
0.0 1.9 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 1.0 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 10.3 PID NECTIN PATHWAY Nectin adhesion pathway
0.3 4.2 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.1 1.5 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.7 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 1.0 PID FOXM1 PATHWAY FOXM1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 10.3 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.6 4.2 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 2.4 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 1.0 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 2.6 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.1 1.0 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 1.7 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1 1.7 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR