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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for zfhx3+zfhx3a+zfhx4

Z-value: 1.29

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Transcription factors associated with zfhx3+zfhx3a+zfhx4

Gene Symbol Gene ID Gene Info
zfhx3a
ENSDARG00000073944 si_ch73-386h18.1
zfhx4
ENSDARG00000075542 zinc finger homeobox 4
zfhx3
ENSDARG00000103057 zinc finger homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
zfhx3dr11_v1_chr7_-_68373495_68373495-0.347.4e-04Click!
zfhx4dr11_v1_chr24_-_23323526_23323526-0.113.1e-01Click!
si:ch73-386h18.1dr11_v1_chr18_+_6054816_6054816-0.066.0e-01Click!

Activity profile of zfhx3+zfhx3a+zfhx4 motif

Sorted Z-values of zfhx3+zfhx3a+zfhx4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_32345187 37.87 ENSDART00000147132
c9
complement component 9
chr5_+_28830643 30.10 ENSDART00000051448
serpina7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr5_+_28830388 29.34 ENSDART00000149150
serpina7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr20_-_40754794 28.14 ENSDART00000187251
cx32.3
connexin 32.3
chr5_+_28848870 27.23 ENSDART00000149563
zgc:174259
zgc:174259
chr5_+_28797771 26.75 ENSDART00000188845
ENSDART00000149066
si:ch211-186e20.7
si:ch211-186e20.7
chr5_+_28849155 26.39 ENSDART00000079090
zgc:174259
zgc:174259
chr22_-_24791505 25.18 ENSDART00000136837
vtg4
vitellogenin 4
chr6_-_40058686 22.95 ENSDART00000103240
uroc1
urocanate hydratase 1
chr20_-_40755614 22.08 ENSDART00000061247
cx32.3
connexin 32.3
chr5_+_28858345 20.73 ENSDART00000111180
si:ch211-186e20.2
si:ch211-186e20.2
chr20_-_15089738 18.91 ENSDART00000164552
si:dkey-239i20.2
si:dkey-239i20.2
chr20_-_40750953 18.54 ENSDART00000061256
cx28.9
connexin 28.9
chr7_+_56577522 17.72 ENSDART00000149130
ENSDART00000149624
hp
haptoglobin
chr6_-_32349153 17.44 ENSDART00000140004
angptl3
angiopoietin-like 3
chr8_-_18042089 16.64 ENSDART00000132596
dio1
iodothyronine deiodinase 1
chr22_-_24818066 16.24 ENSDART00000143443
vtg6
vitellogenin 6
chr7_+_56577906 15.05 ENSDART00000184023
hp
haptoglobin
chr18_+_15644559 13.41 ENSDART00000061794
nr1h4
nuclear receptor subfamily 1, group H, member 4
chr7_-_4296771 13.15 ENSDART00000128855
cbln11
cerebellin 11
chr16_-_25608453 12.57 ENSDART00000140140
zgc:110410
zgc:110410
chr4_+_18804317 10.50 ENSDART00000101043
slc26a3.2
solute carrier family 26 (anion exchanger), member 3, tandem duplicate 2
chr6_-_58764672 10.26 ENSDART00000154322
soat2
sterol O-acyltransferase 2
chr8_+_15254564 9.87 ENSDART00000024433
slc5a9
solute carrier family 5 (sodium/sugar cotransporter), member 9
chr9_+_21151138 9.10 ENSDART00000133903
hao2
hydroxyacid oxidase 2 (long chain)
chr10_+_11261576 7.10 ENSDART00000155333
hsdl2
hydroxysteroid dehydrogenase like 2
chr6_+_30456788 6.27 ENSDART00000121492
FP236735.1

chr20_+_36629173 6.16 ENSDART00000161241
ephx1
epoxide hydrolase 1, microsomal (xenobiotic)
chr5_+_9382301 6.12 ENSDART00000124017
ugt2a7
UDP glucuronosyltransferase 2 family, polypeptide A7
chr16_-_46645396 5.77 ENSDART00000131485
tmem176l.2
transmembrane protein 176l.2
chr5_-_34875858 5.03 ENSDART00000085086
arhgef28
Rho guanine nucleotide exchange factor (GEF) 28
chr21_-_13123176 4.97 ENSDART00000144866
ENSDART00000024616
fam219aa
family with sequence similarity 219, member Aa
chr25_-_35599887 4.84 ENSDART00000153827
clpxb
caseinolytic mitochondrial matrix peptidase chaperone subunit b
chr12_+_47081783 4.65 ENSDART00000158568
mtr
5-methyltetrahydrofolate-homocysteine methyltransferase
chr20_-_25481306 4.46 ENSDART00000182495
si:dkey-183n20.15
si:dkey-183n20.15
chr21_-_20765338 4.27 ENSDART00000135940
ghrb
growth hormone receptor b
chr11_+_23760470 4.23 ENSDART00000175688
ENSDART00000121874
ENSDART00000086720
nfasca
neurofascin homolog (chicken) a
chr15_-_17869115 4.16 ENSDART00000112838
atf5b
activating transcription factor 5b
chr8_-_20230559 3.91 ENSDART00000193677
mllt1a
MLLT1, super elongation complex subunit a
chr15_-_17868870 3.73 ENSDART00000170950
atf5b
activating transcription factor 5b
chr17_+_8212477 3.53 ENSDART00000064665
slc18b1
solute carrier family 18, subfamily B, member 1
chr5_-_30620625 3.47 ENSDART00000098273
tcnl
transcobalamin like
chr16_-_41787421 3.37 ENSDART00000147210
si:dkey-199f5.8
si:dkey-199f5.8
chr4_-_22338906 3.32 ENSDART00000131402
golgb1
golgin B1
chr22_+_14836291 3.32 ENSDART00000122740
gtpbp1l
GTP binding protein 1, like
chr16_-_27566552 3.27 ENSDART00000142102
zgc:153215
zgc:153215
chr6_+_20647155 2.71 ENSDART00000193477
slc19a1
solute carrier family 19 (folate transporter), member 1
chr9_-_14143370 2.69 ENSDART00000108950
ttll4
tubulin tyrosine ligase-like family, member 4
chr3_-_31715714 2.53 ENSDART00000051542
ccdc47
coiled-coil domain containing 47
chr23_+_20689255 2.52 ENSDART00000182420
usp21
ubiquitin specific peptidase 21
chr22_+_20720808 2.44 ENSDART00000171321
si:dkey-211f22.5
si:dkey-211f22.5
chr22_+_13886821 2.39 ENSDART00000130585
ENSDART00000105711
sh3bp4a
SH3-domain binding protein 4a
chr16_-_42894628 2.35 ENSDART00000045600
hfe2
hemochromatosis type 2
chr18_+_7611298 2.19 ENSDART00000062156
odf3b
outer dense fiber of sperm tails 3B
chr17_+_2162916 2.09 ENSDART00000103775
pak6a
p21 protein (Cdc42/Rac)-activated kinase 6a
chr12_+_46582727 2.08 ENSDART00000149326
ush1gb
Usher syndrome 1Gb (autosomal recessive)
chr13_+_45524475 2.06 ENSDART00000074567
ENSDART00000019113
maco1b
macoilin 1b
chr8_+_10339869 2.01 ENSDART00000132253
tbc1d22b
TBC1 domain family, member 22B
chr12_+_30788912 1.96 ENSDART00000160422
aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr17_+_8799661 1.96 ENSDART00000105326
tonsl
tonsoku-like, DNA repair protein
chr18_-_17399291 1.94 ENSDART00000192075
ENSDART00000060949
ENSDART00000188506
zfpm1
zinc finger protein, FOG family member 1
chr14_+_10596628 1.86 ENSDART00000115177
gpr174
G protein-coupled receptor 174
chr5_+_6954162 1.81 ENSDART00000086666
stpg2
sperm-tail PG-rich repeat containing 2
chr3_-_34037064 1.79 ENSDART00000151716
ighv9-4
immunoglobulin heavy variable 9-4
chr25_+_28679672 1.79 ENSDART00000139965
ENSDART00000134072
cnot2
CCR4-NOT transcription complex, subunit 2
chr23_-_41965557 1.75 ENSDART00000144183
slc1a7b
solute carrier family 1 (glutamate transporter), member 7b
chr1_+_44003654 1.71 ENSDART00000131337
si:dkey-22i16.10
si:dkey-22i16.10
chr20_-_9095105 1.70 ENSDART00000140792
oma1
OMA1 zinc metallopeptidase
chr1_+_26480890 1.65 ENSDART00000164430
uso1
USO1 vesicle transport factor
chr12_-_18578218 1.65 ENSDART00000125803
zdhhc4
zinc finger, DHHC-type containing 4
chr18_-_22713402 1.59 ENSDART00000145871
si:ch73-113g13.2
si:ch73-113g13.2
chr18_-_22713621 1.55 ENSDART00000079013
si:ch73-113g13.2
si:ch73-113g13.2
chr14_-_7207961 1.50 ENSDART00000167994
ENSDART00000166532
stox2b
storkhead box 2b
chr23_+_24589633 1.49 ENSDART00000143694
mlh3
mutL homolog 3 (E. coli)
chr9_+_45227028 1.41 ENSDART00000185579
adarb1b
adenosine deaminase, RNA-specific, B1b
chr9_+_12444494 1.32 ENSDART00000102430
tmem41aa
transmembrane protein 41aa
chr15_+_38299385 1.31 ENSDART00000142403
si:dkey-24p1.6
si:dkey-24p1.6
chr5_+_9224051 1.23 ENSDART00000139265
si:ch211-12e13.12
si:ch211-12e13.12
chr19_-_3056235 1.22 ENSDART00000137020
bop1
block of proliferation 1
chr12_-_18578432 1.12 ENSDART00000122858
zdhhc4
zinc finger, DHHC-type containing 4
chr3_-_34066548 1.11 ENSDART00000151302
ighv9-2
immunoglobulin heavy variable 9-2
chr4_+_57881965 1.10 ENSDART00000162234
si:dkeyp-44b5.4
si:dkeyp-44b5.4
chr3_-_5228137 1.08 ENSDART00000137105
myh9b
myosin, heavy chain 9b, non-muscle
chr9_+_52613820 1.06 ENSDART00000168753
ENSDART00000165580
ENSDART00000164769
si:ch211-241j8.2
si:ch211-241j8.2
chr13_+_25286538 1.05 ENSDART00000180282
chuk
conserved helix-loop-helix ubiquitous kinase
chr16_-_31351419 1.04 ENSDART00000178298
ENSDART00000018091
mroh1
maestro heat-like repeat family member 1
chr3_-_30388525 1.00 ENSDART00000183790
lrrc4ba
leucine rich repeat containing 4Ba
chr25_+_29474583 0.95 ENSDART00000191189
il17rel
interleukin 17 receptor E-like
chr16_+_24733741 0.84 ENSDART00000155217
si:dkey-79d12.4
si:dkey-79d12.4
chr8_+_1839695 0.81 ENSDART00000148254
ENSDART00000143473
snap29
synaptosomal-associated protein 29
chr20_-_38617766 0.76 ENSDART00000050474
slc30a2
solute carrier family 30 (zinc transporter), member 2
chr18_+_36914221 0.76 ENSDART00000147656
si:ch211-238g23.1
si:ch211-238g23.1
chr10_+_8197827 0.75 ENSDART00000026244
mtrex
Mtr4 exosome RNA helicase
chr2_+_29249561 0.72 ENSDART00000099157
cdh18a
cadherin 18, type 2a
chr11_-_2838699 0.59 ENSDART00000066189
lhfpl5a
LHFPL tetraspan subfamily member 5a
chr14_+_2487672 0.52 ENSDART00000170629
ENSDART00000123063
fgf18a
fibroblast growth factor 18a
chr23_+_21473103 0.50 ENSDART00000142921
si:ch73-21g5.7
si:ch73-21g5.7
chr24_-_2450597 0.48 ENSDART00000188080
ENSDART00000093331
rreb1a
ras responsive element binding protein 1a
chr10_+_42423318 0.41 ENSDART00000134282
npy8ar
neuropeptide Y receptor Y8a
chr8_-_20230802 0.37 ENSDART00000063400
mllt1a
MLLT1, super elongation complex subunit a
chr15_+_34988148 0.37 ENSDART00000076269
ccdc105
coiled-coil domain containing 105
chr24_+_26329018 0.33 ENSDART00000145752
mynn
myoneurin
chr15_+_38299563 0.31 ENSDART00000099375
si:dkey-24p1.6
si:dkey-24p1.6
chr17_+_9310259 0.28 ENSDART00000186158
ENSDART00000190329
NPAS3
neuronal PAS domain protein 3
chr17_-_24820801 0.27 ENSDART00000156606
trmt61b
tRNA methyltransferase 61B
chr23_+_13375359 0.24 ENSDART00000151947
ZNF512B
si:dkey-256k13.2
chr10_-_8197049 0.17 ENSDART00000129467
dhx29
DEAH (Asp-Glu-Ala-His) box polypeptide 29
chr21_+_37513488 0.16 ENSDART00000185394
amot
angiomotin
chr5_+_19933356 0.14 ENSDART00000088819
ankrd13a
ankyrin repeat domain 13A
chr17_+_31914877 0.14 ENSDART00000177801
FAM196A (1 of many)
family with sequence similarity 196 member A
chr19_+_20274491 0.13 ENSDART00000090860
ENSDART00000151693
oxnad1
oxidoreductase NAD-binding domain containing 1
chr4_-_27117112 0.11 ENSDART00000034534
zbed4
zinc finger, BED-type containing 4
chr7_-_17412559 0.09 ENSDART00000163020
nitr3a
novel immune-type receptor 3a
chr6_-_29515709 0.04 ENSDART00000180205
pex5la
peroxisomal biogenesis factor 5-like a

Network of associatons between targets according to the STRING database.

First level regulatory network of zfhx3+zfhx3a+zfhx4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
12.6 37.9 GO:0006957 complement activation, alternative pathway(GO:0006957)
7.6 22.9 GO:0043606 formate metabolic process(GO:0015942) histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
4.4 17.4 GO:0055091 phospholipid homeostasis(GO:0055091)
2.4 16.6 GO:0042403 thyroid hormone metabolic process(GO:0042403)
1.8 160.5 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
1.1 10.3 GO:0034434 steroid esterification(GO:0034433) sterol esterification(GO:0034434) cholesterol esterification(GO:0034435)
1.1 41.4 GO:0032355 response to estradiol(GO:0032355)
0.9 2.7 GO:0015893 folic acid transport(GO:0015884) drug transport(GO:0015893) methotrexate transport(GO:0051958) reduced folate transmembrane transport(GO:0098838)
0.8 13.4 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.6 2.4 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.5 10.5 GO:0015701 bicarbonate transport(GO:0015701)
0.4 1.6 GO:0048211 Golgi vesicle docking(GO:0048211)
0.4 2.1 GO:0023041 neuronal signal transduction(GO:0023041)
0.4 1.9 GO:0030219 megakaryocyte differentiation(GO:0030219)
0.3 4.3 GO:0060396 growth hormone receptor signaling pathway(GO:0060396) response to growth hormone(GO:0060416) cellular response to growth hormone stimulus(GO:0071378)
0.3 4.7 GO:0009086 methionine biosynthetic process(GO:0009086)
0.2 2.1 GO:0050957 equilibrioception(GO:0050957)
0.2 2.0 GO:0006561 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.2 1.7 GO:1990845 adaptive thermogenesis(GO:1990845)
0.2 1.1 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.2 6.2 GO:0009636 response to toxic substance(GO:0009636)
0.2 1.1 GO:0070650 actin filament bundle distribution(GO:0070650)
0.2 1.8 GO:2000036 regulation of stem cell population maintenance(GO:2000036)
0.2 0.8 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.2 1.1 GO:0000706 meiotic DNA double-strand break processing(GO:0000706)
0.1 2.7 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 1.4 GO:0006382 adenosine to inosine editing(GO:0006382)
0.1 2.5 GO:0021551 central nervous system morphogenesis(GO:0021551)
0.1 0.8 GO:0048730 epidermis morphogenesis(GO:0048730)
0.1 1.7 GO:0031297 replication fork processing(GO:0031297)
0.1 2.8 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 1.2 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.1 6.9 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 0.3 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.1 1.5 GO:0006298 mismatch repair(GO:0006298)
0.0 7.8 GO:0006814 sodium ion transport(GO:0006814)
0.0 3.6 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 4.8 GO:0006457 protein folding(GO:0006457)
0.0 4.2 GO:0007422 peripheral nervous system development(GO:0007422)
0.0 0.8 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.0 0.6 GO:0050974 detection of mechanical stimulus involved in sensory perception(GO:0050974)
0.0 0.2 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.0 0.2 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.0 2.0 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 19.9 GO:0006508 proteolysis(GO:0006508)
0.0 0.7 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 1.2 GO:0008360 regulation of cell shape(GO:0008360)
0.0 3.4 GO:0043413 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
12.6 37.9 GO:0044217 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
1.1 4.3 GO:0070195 growth hormone receptor complex(GO:0070195)
0.4 1.2 GO:0070545 PeBoW complex(GO:0070545)
0.2 1.7 GO:0005662 DNA replication factor A complex(GO:0005662)
0.2 4.6 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.2 3.3 GO:0005801 cis-Golgi network(GO:0005801)
0.2 1.1 GO:0000801 central element(GO:0000801)
0.2 1.1 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 1.5 GO:0032300 mismatch repair complex(GO:0032300)
0.1 200.9 GO:0005615 extracellular space(GO:0005615)
0.1 1.8 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 6.7 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 0.3 GO:0031515 tRNA (m1A) methyltransferase complex(GO:0031515)
0.0 1.6 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 2.4 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 26.8 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 4.8 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 2.7 GO:0016324 apical plasma membrane(GO:0016324)
0.0 1.0 GO:0032580 Golgi cisterna membrane(GO:0032580)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.9 41.4 GO:0045735 nutrient reservoir activity(GO:0045735)
2.6 10.3 GO:0034736 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
2.2 13.4 GO:0032052 bile acid binding(GO:0032052)
2.1 18.9 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
2.1 6.2 GO:0033961 cis-stilbene-oxide hydrolase activity(GO:0033961)
1.6 9.9 GO:0005412 glucose:sodium symporter activity(GO:0005412)
1.4 160.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
1.1 4.3 GO:0004903 growth hormone receptor activity(GO:0004903)
0.9 2.7 GO:0008518 reduced folate carrier activity(GO:0008518) methotrexate transporter activity(GO:0015350)
0.6 4.7 GO:0031419 cobalamin binding(GO:0031419)
0.6 10.5 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.4 9.1 GO:0010181 FMN binding(GO:0010181)
0.4 2.0 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.3 22.9 GO:0016836 hydro-lyase activity(GO:0016836)
0.3 1.1 GO:0008384 IkappaB kinase activity(GO:0008384)
0.2 2.7 GO:0070740 protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.1 2.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 29.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 1.4 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.1 3.4 GO:0008378 galactosyltransferase activity(GO:0008378)
0.1 6.1 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 3.6 GO:0042923 neuropeptide binding(GO:0042923)
0.1 1.5 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 1.0 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 0.5 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 2.8 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 0.3 GO:0016429 tRNA (adenine-N1-)-methyltransferase activity(GO:0016429)
0.1 4.8 GO:0051082 unfolded protein binding(GO:0051082)
0.0 8.4 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 23.2 GO:0016491 oxidoreductase activity(GO:0016491)
0.0 1.2 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.0 0.7 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.9 GO:0003724 RNA helicase activity(GO:0003724)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 13.4 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.4 58.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 17.4 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.1 1.1 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.1 1.6 PID ARF 3PATHWAY Arf1 pathway
0.1 1.7 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.1 2.3 PID BMP PATHWAY BMP receptor signaling
0.0 1.9 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 16.6 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
1.4 37.9 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.2 4.7 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 2.0 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.2 22.9 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 1.1 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 1.8 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 2.3 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 0.8 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 2.7 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.5 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 1.9 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production