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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for zgc:101100

Z-value: 0.57

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Transcription factors associated with zgc:101100

Gene Symbol Gene ID Gene Info
ENSDARG00000021959 101100

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
zgc:101100dr11_v1_chr8_+_20488322_204883220.631.0e-11Click!

Activity profile of zgc:101100 motif

Sorted Z-values of zgc:101100 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr25_+_3326885 5.80 ENSDART00000104866
lactate dehydrogenase Bb
chr3_-_49566364 5.62 ENSDART00000161507
zgc:153426
chr2_-_30784198 5.22 ENSDART00000182523
ENSDART00000147355
regulator of G protein signaling 20
chr20_-_29475172 4.92 ENSDART00000183164
secretogranin V
chr12_+_41991635 4.92 ENSDART00000186161
ENSDART00000192510
transcription elongation regulator 1 like
chr24_-_38079261 4.72 ENSDART00000105662
C-reactive protein 1
chr22_+_5103349 4.63 ENSDART00000083474
ataxia, cerebellar, Cayman type a
chr20_-_18736281 4.48 ENSDART00000142837
ectonucleotide pyrophosphatase/phosphodiesterase 5
chr20_+_53441935 4.01 ENSDART00000175214
apolipoprotein Bb, tandem duplicate 2
chr16_+_32059785 3.93 ENSDART00000134459
si:dkey-40m6.8
chr5_-_50748081 3.80 ENSDART00000113985
multiple C2 domains, transmembrane 1a
chr7_-_49594995 3.79 ENSDART00000174161
ENSDART00000109147
BR serine/threonine kinase 2b
chr7_-_57933736 3.69 ENSDART00000142580
ankyrin 2b, neuronal
chr19_+_1097393 3.65 ENSDART00000168218

chr12_-_10705916 3.41 ENSDART00000164038

chr22_+_34701848 3.39 ENSDART00000082066
ATPase H+ transporting V0 subunit e2
chr1_-_45920632 3.38 ENSDART00000140890
patatin-like phospholipase domain containing 6
chr16_-_31675669 3.36 ENSDART00000168848
ENSDART00000158331
complement component 1, r subcomponent
chr9_+_13714379 3.16 ENSDART00000017593
ENSDART00000145503
transmembrane protein 237a
chr10_+_6013076 3.10 ENSDART00000167613
ENSDART00000159216
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr3_+_34220194 3.08 ENSDART00000145859
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23b
chr15_-_23793641 2.91 ENSDART00000122891
transmembrane protein 97
chr3_+_34919810 2.85 ENSDART00000055264
carbonic anhydrase Xb
chr5_+_52067723 2.73 ENSDART00000166902
SET binding protein 1
chr10_+_17026870 2.30 ENSDART00000184529
ENSDART00000157480

chr5_+_66355153 2.18 ENSDART00000082745
si:ch211-261c8.5
chr1_+_55758257 2.12 ENSDART00000139312
trans-2,3-enoyl-CoA reductase b
chr1_+_47585700 1.87 ENSDART00000153746
ENSDART00000084457
SH3 and PX domains 2Aa
chr15_-_26887028 1.75 ENSDART00000156292
si:dkey-243i1.1
chr23_-_35694461 1.61 ENSDART00000185884
tubulin, alpha 1c
chr2_+_13050225 1.59 ENSDART00000182237

chr23_-_10137322 1.55 ENSDART00000142442
plexin b1a
chr1_+_41690402 1.51 ENSDART00000177298
F-box protein 41
chr19_-_40906161 1.43 ENSDART00000004514
Bet1 golgi vesicular membrane trafficking protein
chr11_+_30296332 1.41 ENSDART00000192843
UDP glucuronosyltransferase 1 family, polypeptide B7
chr23_-_21797517 1.38 ENSDART00000110041
leucine rich repeat containing 38a
chr7_+_20031202 1.32 ENSDART00000052904
solute carrier family 16, member 13 (monocarboxylic acid transporter 13)
chr10_+_2841205 1.29 ENSDART00000131505
ENSDART00000055869
YKT6 v-SNARE homolog (S. cerevisiae)
chr11_-_3366782 1.28 ENSDART00000127982
sulfite oxidase
chr19_-_32518556 1.23 ENSDART00000103410
zinc finger and BTB domain containing 8B
chr6_-_17999776 1.21 ENSDART00000183048
ENSDART00000181577
ENSDART00000170597
regulatory associated protein of MTOR, complex 1
chr17_-_15149192 1.19 ENSDART00000180511
ENSDART00000103405
GTP cyclohydrolase 1
chr5_-_28625515 1.12 ENSDART00000190782
ENSDART00000179736
ENSDART00000131729
tenascin C
chr5_+_31791001 1.12 ENSDART00000043010
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25b
chr10_-_7988396 1.07 ENSDART00000141445
ENSDART00000024282
EWS RNA-binding protein 1a
chr18_+_19975787 1.00 ENSDART00000138103
SKI family transcriptional corepressor 1b
chr6_-_39653972 1.00 ENSDART00000155859
La ribonucleoprotein domain family, member 4Ab
chr17_+_35097024 0.99 ENSDART00000026152
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2a
chr17_-_50010121 0.98 ENSDART00000122747
transmembrane protein 30Aa
chr23_-_20345473 0.97 ENSDART00000140935
si:rp71-17i16.6
chr19_+_24068223 0.95 ENSDART00000141351
ENSDART00000100420
peroxisomal biogenesis factor 11 beta
chr24_-_25004553 0.90 ENSDART00000080997
ENSDART00000136860
zinc finger, DHHC-type containing 20b
chr2_-_48171441 0.84 ENSDART00000123040
phosphofructokinase, platelet b
chr13_-_50614639 0.82 ENSDART00000170527
ventral expressed homeobox
chr18_+_7639401 0.79 ENSDART00000092416
RAB, member of RAS oncogene family-like 2
chr11_+_25583950 0.79 ENSDART00000111961
coiled-coil domain containing 120
chr14_-_2933185 0.78 ENSDART00000161677
ENSDART00000162446
ENSDART00000109378
si:dkey-201i24.6
chr7_-_12821277 0.78 ENSDART00000091584
zgc:158785
chr21_+_44773237 0.77 ENSDART00000084780
ring finger protein 121
chr13_-_36525982 0.76 ENSDART00000114744
phosphofurin acidic cluster sorting protein 2
chr15_-_15469079 0.74 ENSDART00000132637
ENSDART00000004220
RAB34, member RAS oncogene family a
chr10_+_28428222 0.70 ENSDART00000135003
si:ch211-222e20.4
chr8_+_23142946 0.69 ENSDART00000152933
si:ch211-196c10.13
chr10_-_26274094 0.66 ENSDART00000108798
dachsous cadherin-related 1b
chr14_-_46395408 0.65 ENSDART00000147537
Bardet-Biedl syndrome 7
chr2_+_30786773 0.61 ENSDART00000019029
ENSDART00000145681
ATPase H+ transporting V1 subunit H
chr16_-_17188294 0.57 ENSDART00000165883
opsin 9
chr1_+_50613868 0.56 ENSDART00000111114
si:ch73-190m4.1
chr9_-_12682848 0.53 ENSDART00000138360
myosin X-like 3
chr6_-_2222707 0.51 ENSDART00000022179
protein kinase, AMP-activated, gamma 1 non-catalytic subunit
chr7_-_17780048 0.50 ENSDART00000183336
si:dkey-106g10.7
chr7_-_17779644 0.50 ENSDART00000128504
si:dkey-106g10.7
chr9_-_29544720 0.42 ENSDART00000130317
Rho GTPase activating protein 20
chr21_-_15046065 0.42 ENSDART00000178507
matrix metallopeptidase 17a
chr22_+_438714 0.41 ENSDART00000136491
cadherin, EGF LAG seven-pass G-type receptor 2
chr21_-_41369370 0.40 ENSDART00000159290
cytoplasmic polyadenylation element binding protein 4b
chr5_+_24287927 0.40 ENSDART00000143563
zinc finger, DHHC-type containing 23a
chr2_+_30787128 0.38 ENSDART00000189233
ATPase H+ transporting V1 subunit H
chr15_+_5973909 0.38 ENSDART00000126886
ENSDART00000189618
immunoglobulin superfamily, member 5b
chr2_-_9696283 0.34 ENSDART00000165712
selenoprotein T, 1a
chr14_+_32837914 0.34 ENSDART00000158888
arrestin 3b, retinal (X-arrestin)
chr23_+_6544453 0.34 ENSDART00000005373
SPO11 meiotic protein covalently bound to DSB
chr6_-_33924883 0.33 ENSDART00000132762
ENSDART00000148142
ENSDART00000142213
aldo-keto reductase family 1, member A1b (aldehyde reductase)
chr20_+_34671386 0.31 ENSDART00000152836
ENSDART00000138226
elongator acetyltransferase complex subunit 3
chr4_+_65271779 0.31 ENSDART00000134257
zinc finger protein 1027
chr3_-_38918697 0.30 ENSDART00000145630
si:dkey-106c17.2
chr11_+_15613218 0.29 ENSDART00000066033
growth differentiation factor 11
chr3_-_8510201 0.29 ENSDART00000009151

chr13_-_33153889 0.28 ENSDART00000141451
tandem C2 domains, nuclear
chr22_+_35275468 0.27 ENSDART00000189516
ENSDART00000181572
ENSDART00000165353
ENSDART00000185352
RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein
chr8_+_2656231 0.26 ENSDART00000160833
family with sequence similarity 102, member Aa
chr16_+_16265850 0.24 ENSDART00000181265
SET domain containing 2
chr16_+_50163352 0.21 ENSDART00000153890
ENSDART00000060522
si:ch211-231m23.4
chr18_-_25646286 0.19 ENSDART00000099511
ENSDART00000186890
si:ch211-13k12.2
chr6_-_59381391 0.18 ENSDART00000157066
protein phosphatase 1, regulatory subunit 16B
chr25_-_17503393 0.17 ENSDART00000061726
tripartite motif containing 35-40
chr6_+_41186320 0.16 ENSDART00000025241
opsin 1 (cone pigments), medium-wave-sensitive, 2
chr22_-_14696667 0.13 ENSDART00000180379
low density lipoprotein receptor-related protein 1Ba
chr25_-_32381642 0.11 ENSDART00000133872
ENSDART00000006124
COP9 signalosome subunit 2
chr14_-_22152064 0.11 ENSDART00000115422
NudC domain containing 2
chr2_+_30531726 0.10 ENSDART00000146518
ankyrin repeat domain 33Bb
chr5_-_38107741 0.05 ENSDART00000156853
si:ch211-284e13.14

Network of associatons between targets according to the STRING database.

First level regulatory network of zgc:101100

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.1 GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway(GO:0010142) isoprenoid biosynthetic process via mevalonate(GO:1902767)
0.8 4.0 GO:0006642 triglyceride mobilization(GO:0006642)
0.7 3.7 GO:0036371 protein localization to T-tubule(GO:0036371)
0.4 4.6 GO:0006798 polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.4 1.1 GO:0014814 regulation of synaptic growth at neuromuscular junction(GO:0008582) axon regeneration at neuromuscular junction(GO:0014814) positive regulation of synaptic growth at neuromuscular junction(GO:0045887)
0.3 1.2 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.3 1.1 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.3 0.8 GO:1903069 regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903069)
0.2 3.4 GO:0046470 phosphatidylcholine metabolic process(GO:0046470)
0.2 0.7 GO:1903673 mitotic cytokinetic process(GO:1902410) mitotic cleavage furrow formation(GO:1903673)
0.2 1.0 GO:0016559 peroxisome fission(GO:0016559)
0.2 1.4 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.1 1.0 GO:0048069 eye pigmentation(GO:0048069)
0.1 4.3 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 0.3 GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis.(GO:0002926)
0.1 4.9 GO:0046883 regulation of hormone secretion(GO:0046883)
0.1 0.3 GO:0090219 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) negative regulation of lipid kinase activity(GO:0090219) negative regulation of phospholipid metabolic process(GO:1903726)
0.1 0.7 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.1 1.6 GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.1 3.8 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.1 0.8 GO:0042661 regulation of mesodermal cell fate specification(GO:0042661)
0.1 1.9 GO:0006801 superoxide metabolic process(GO:0006801)
0.1 0.7 GO:0051877 pigment granule aggregation in cell center(GO:0051877)
0.1 2.1 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.1 3.4 GO:0031638 zymogen activation(GO:0031638)
0.1 0.6 GO:0061621 glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.1 0.4 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.1 1.7 GO:0007099 centriole replication(GO:0007099)
0.1 2.8 GO:0036269 swimming behavior(GO:0036269)
0.0 0.3 GO:0000706 meiotic DNA double-strand break processing(GO:0000706)
0.0 1.2 GO:0071230 cellular response to amino acid stimulus(GO:0071230)
0.0 3.4 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.0 0.2 GO:0097198 histone H3-K36 trimethylation(GO:0097198)
0.0 1.3 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.4 GO:0031294 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0 0.4 GO:0021754 facial nucleus development(GO:0021754)
0.0 1.0 GO:0045332 phospholipid translocation(GO:0045332)
0.0 1.1 GO:0060972 left/right pattern formation(GO:0060972)
0.0 0.1 GO:0000338 protein deneddylation(GO:0000338)
0.0 3.2 GO:0060027 convergent extension involved in gastrulation(GO:0060027)
0.0 1.0 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 0.2 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
0.0 1.3 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 0.3 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.4 GO:0030574 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.0 GO:0034359 mature chylomicron(GO:0034359)
0.2 3.7 GO:0030315 T-tubule(GO:0030315)
0.2 3.4 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.2 1.4 GO:0000138 Golgi trans cisterna(GO:0000138)
0.2 1.2 GO:0031931 TORC1 complex(GO:0031931)
0.1 1.0 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.1 1.9 GO:0002102 podosome(GO:0002102)
0.1 1.0 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 0.7 GO:0034464 BBSome(GO:0034464)
0.1 1.6 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 4.9 GO:0031514 motile cilium(GO:0031514)
0.1 2.2 GO:0035869 ciliary transition zone(GO:0035869)
0.1 0.6 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 3.8 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.3 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 1.4 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 1.0 GO:0030658 transport vesicle membrane(GO:0030658)
0.0 3.8 GO:0005813 centrosome(GO:0005813)
0.0 0.7 GO:0016342 catenin complex(GO:0016342)
0.0 3.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.1 GO:0008180 COP9 signalosome(GO:0008180)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.1 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.8 5.8 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.4 4.0 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750) lipoprotein particle receptor binding(GO:0070325)
0.4 4.6 GO:0004309 exopolyphosphatase activity(GO:0004309)
0.2 1.9 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175) superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.2 3.7 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.2 3.8 GO:0050321 tau-protein kinase activity(GO:0050321)
0.2 3.4 GO:0004622 lysophospholipase activity(GO:0004622)
0.1 2.8 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 1.2 GO:0019238 cyclohydrolase activity(GO:0019238)
0.1 1.3 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.1 4.2 GO:0005347 ATP transmembrane transporter activity(GO:0005347)
0.1 0.3 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 0.6 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.1 1.6 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.2 GO:0017020 myosin phosphatase regulator activity(GO:0017020)
0.0 0.3 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 2.1 GO:0044325 ion channel binding(GO:0044325)
0.0 1.0 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.3 GO:0016889 endodeoxyribonuclease activity, producing 3'-phosphomonoesters(GO:0016889)
0.0 0.5 GO:0016208 AMP binding(GO:0016208)
0.0 2.1 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.0 1.3 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.4 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.4 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.1 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 1.3 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 1.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.2 GO:0030674 protein binding, bridging(GO:0030674)
0.0 1.0 GO:0046332 SMAD binding(GO:0046332)
0.0 0.2 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 3.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.2 ST G ALPHA I PATHWAY G alpha i Pathway
0.1 1.1 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 3.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.7 PID LKB1 PATHWAY LKB1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.2 1.7 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.1 3.1 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 5.2 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.1 1.0 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.1 1.3 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.6 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 1.1 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions