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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for znf148

Z-value: 0.64

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Transcription factors associated with znf148

Gene Symbol Gene ID Gene Info
ENSDARG00000055106 zinc finger protein 148

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
znf148dr11_v1_chr9_+_38624478_38624533-0.075.0e-01Click!

Activity profile of znf148 motif

Sorted Z-values of znf148 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_233143 9.44 ENSDART00000175273
synaptic Ras GTPase activating protein 1a
chr3_-_31804481 7.98 ENSDART00000028270
glial fibrillary acidic protein
chr9_-_7539297 7.61 ENSDART00000081550
ENSDART00000081553
desmin a
chr12_-_41618844 5.84 ENSDART00000160054
dihydropyrimidinase-like 4
chr8_+_31821396 5.76 ENSDART00000077053
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr22_+_34701848 5.14 ENSDART00000082066
ATPase H+ transporting V0 subunit e2
chr2_+_6181383 5.13 ENSDART00000153307
si:ch73-344o19.1
chr6_-_52156427 5.02 ENSDART00000082821
regulating synaptic membrane exocytosis 4
chr17_+_45454943 4.68 ENSDART00000074838
potassium channel, subfamily K, member 3b
chr12_-_41619257 3.83 ENSDART00000162967
dihydropyrimidinase-like 4
chr9_-_6927587 3.81 ENSDART00000059092
transmembrane protein 182a
chr7_+_13039426 3.76 ENSDART00000171777
synaptotagmin VIIb
chr20_+_52554352 3.48 ENSDART00000153217
ENSDART00000145230
eukaryotic translation elongation factor 1 delta b (guanine nucleotide exchange protein)
chr24_-_3419998 3.40 ENSDART00000066839
solute carrier family 35, member G2b
chr16_+_5678071 3.17 ENSDART00000011166
ENSDART00000134198
ENSDART00000131575
zgc:158689
chr16_-_12914288 3.00 ENSDART00000184221
calcium channel, voltage-dependent, gamma subunit 8b
chr6_-_9581949 2.87 ENSDART00000144335
cytochrome P450, family 27, subfamily C, polypeptide 1
chr23_+_28648864 2.73 ENSDART00000189096
L1 cell adhesion molecule, paralog a
chr24_-_40667800 2.61 ENSDART00000169315
slow myosin heavy chain 1
chr13_+_23214100 2.61 ENSDART00000163393
sorbin and SH3 domain containing 1
chr10_-_32851847 2.58 ENSDART00000134255
tripartite motif containing 37
chr15_+_42767803 2.50 ENSDART00000164879
solute carrier family 8 (sodium/calcium exchanger), member 2b
chr10_+_1638876 2.49 ENSDART00000184484
ENSDART00000060946
ENSDART00000181251
small G protein signaling modulator 1b
chr24_+_39129316 2.30 ENSDART00000155346
TBC1 domain family, member 24
chr2_-_6182098 2.24 ENSDART00000156167
si:ch73-182a11.2
chr14_-_26177156 2.19 ENSDART00000014149
FAT atypical cadherin 2
chr11_-_44030962 2.15 ENSDART00000171910

chr6_+_12865137 2.06 ENSDART00000090065
family with sequence similarity 117, member Ba
chr7_+_568819 2.05 ENSDART00000173716
neurexin 2b
chr5_-_21030934 2.00 ENSDART00000133461
ENSDART00000098667
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1
chr24_+_1294176 1.98 ENSDART00000106637
si:ch73-134f24.1
chr2_+_59015878 1.94 ENSDART00000148816
ENSDART00000122795
si:ch1073-391i24.1
chr24_-_21490628 1.92 ENSDART00000181546
ATPase phospholipid transporting 8A2
chr15_-_29388012 1.91 ENSDART00000115032
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b
chr23_-_29667544 1.86 ENSDART00000059339
calsyntenin 1
chr4_+_37406676 1.75 ENSDART00000130981
si:ch73-134f24.1
chr6_-_12275836 1.74 ENSDART00000189980
plakophilin 4
chr16_-_21181128 1.73 ENSDART00000133403
phosphodiesterase 11a, like
chr17_+_22311413 1.72 ENSDART00000151929
solute carrier family 8 (sodium/calcium exchanger), member 1b
chr24_-_40668208 1.66 ENSDART00000171543
slow myosin heavy chain 1
chr7_-_6279138 1.64 ENSDART00000173299
si:ch211-220f21.2
chr25_+_13791627 1.51 ENSDART00000159278
zgc:92873
chr13_+_12045475 1.47 ENSDART00000163053
ENSDART00000160812
ENSDART00000158244
guanine nucleotide binding protein (G protein), gamma 2
chr1_+_27052530 1.35 ENSDART00000184065
basonuclin 2
chr14_-_41556533 1.23 ENSDART00000074401
integrin, alpha 6, like
chr6_+_41554794 1.22 ENSDART00000165424
SLIT-ROBO Rho GTPase activating protein 3
chr22_-_506522 1.21 ENSDART00000106645
ENSDART00000067637
dual serine/threonine and tyrosine protein kinase
chr10_+_31951338 1.20 ENSDART00000019416
LHFPL tetraspan subfamily member 6
chr7_-_1918971 1.19 ENSDART00000181759

chr5_+_483965 1.19 ENSDART00000150007
TEK tyrosine kinase, endothelial
chr13_+_12045758 1.15 ENSDART00000079398
ENSDART00000165467
ENSDART00000165880
guanine nucleotide binding protein (G protein), gamma 2
chr5_+_41793001 1.11 ENSDART00000136439
ENSDART00000190477
ENSDART00000192289
BCL tumor suppressor 7A
chr14_-_2933185 1.09 ENSDART00000161677
ENSDART00000162446
ENSDART00000109378
si:dkey-201i24.6
chr8_+_9866351 1.07 ENSDART00000133985
potassium voltage-gated channel, Shal-related subfamily, member 1
chr23_-_351935 1.06 ENSDART00000140986
UHRF1 binding protein 1
chr22_-_38360205 1.05 ENSDART00000162055
MAP/microtubule affinity-regulating kinase 1
chr2_-_12243213 0.92 ENSDART00000113081
G protein-coupled receptor 158b
chr7_-_71837213 0.92 ENSDART00000168645
ENSDART00000160512
calcium channel, voltage-dependent, beta 2a
chr1_+_27053010 0.90 ENSDART00000161169
basonuclin 2
chr4_-_11751037 0.88 ENSDART00000102301
podocalyxin-like
chr11_+_31558207 0.81 ENSDART00000140204
egl-9 family hypoxia-inducible factor 1b
chr9_-_43213229 0.81 ENSDART00000139775
SEC14 and spectrin domains 1
chr5_+_4564233 0.79 ENSDART00000193435

chr14_+_18781082 0.77 ENSDART00000108793
si:ch211-111e20.1
chr8_-_22826996 0.77 ENSDART00000146563
MAGI family member, X-linked a
chr13_-_27767330 0.76 ENSDART00000131631
ENSDART00000112553
ENSDART00000189911
regulating synaptic membrane exocytosis 1a
chr17_-_52636937 0.75 ENSDART00000084268
family with sequence similarity 98, member B
chr3_-_2591942 0.74 ENSDART00000127971
si:dkey-217f16.5
chr20_+_17739923 0.70 ENSDART00000024627
cadherin 2, type 1, N-cadherin (neuronal)
chr9_+_30274637 0.69 ENSDART00000079095
retinitis pigmentosa GTPase regulator a
chr8_-_1956632 0.65 ENSDART00000131602
si:dkey-178e17.1
chr14_+_7939216 0.61 ENSDART00000171657
CXXC finger protein 5b
chr18_-_14337065 0.54 ENSDART00000135703
heat shock factor binding protein 1b
chr22_-_11438627 0.53 ENSDART00000007649
MID1 interacting protein 1b
chr20_-_1454131 0.52 ENSDART00000138059
protein tyrosine phosphatase, receptor type, K
chr25_-_20666328 0.50 ENSDART00000098076
C-terminal Src kinase
chr14_+_15543331 0.47 ENSDART00000167025
si:dkey-203a12.7
chr25_-_28587896 0.43 ENSDART00000111908
si:dkeyp-67e1.6
chr23_-_4930229 0.43 ENSDART00000189456
nerve growth factor a (beta polypeptide)
chr13_-_40302710 0.41 ENSDART00000144360
pyridine nucleotide-disulphide oxidoreductase domain 2
chr14_-_45702721 0.39 ENSDART00000165727
si:dkey-226n24.1
chr6_+_4084739 0.39 ENSDART00000087661
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Bb
chr9_-_43213057 0.38 ENSDART00000059448
ENSDART00000133589
SEC14 and spectrin domains 1
chr14_+_7939398 0.35 ENSDART00000189773
CXXC finger protein 5b
chr17_-_52521002 0.35 ENSDART00000114931
prospero homeobox 2
chr15_+_3125136 0.32 ENSDART00000130968
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr18_+_33353755 0.30 ENSDART00000144160
vomeronasal 2 receptor, h13
chr9_-_30274412 0.28 ENSDART00000089526
ornithine carbamoyltransferase
chr11_+_6116503 0.25 ENSDART00000176170
nuclear receptor subfamily 2, group F, member 6b
chr11_-_7029897 0.25 ENSDART00000077406
ENSDART00000184582
ENSDART00000180369
cadherin 27
chr2_+_50477779 0.25 ENSDART00000122716

chr22_+_30035719 0.22 ENSDART00000192238

chr24_+_42132962 0.20 ENSDART00000187739
WW domain containing E3 ubiquitin protein ligase 1
chr14_-_41556720 0.19 ENSDART00000149244
integrin, alpha 6, like
chr25_-_16554757 0.19 ENSDART00000154480
si:ch211-266k8.6
chr7_-_1101071 0.18 ENSDART00000176053
dynactin 1a
chr17_-_36818176 0.18 ENSDART00000061762
myosin VIb
chr11_-_27537593 0.18 ENSDART00000173444
ENSDART00000172895
ENSDART00000088177
protein tyrosine phosphatase domain containing 1a
chr21_-_11632403 0.17 ENSDART00000171708
ENSDART00000138619
ENSDART00000136308
ENSDART00000144770
calpastatin
chr8_-_26709959 0.14 ENSDART00000135215
transmembrane protein 51a
chr17_-_4245311 0.13 ENSDART00000055379
growth differentiation factor 3
chr2_-_12242695 0.13 ENSDART00000158175
G protein-coupled receptor 158b
chr23_+_20518504 0.12 ENSDART00000114246
activity-dependent neuroprotector homeobox b
chr18_-_16885362 0.10 ENSDART00000132778
switching B cell complex subunit SWAP70b
chr13_-_35459928 0.09 ENSDART00000144109
SLX4 interacting protein
chr8_-_410728 0.09 ENSDART00000151255
tripartite motif containing 36
chr3_-_1938588 0.06 ENSDART00000013001
ENSDART00000186405
zgc:152753
chr6_+_36459897 0.05 ENSDART00000104248
ENSDART00000145753
leucine rich repeat containing 15
chr9_+_56449505 0.05 ENSDART00000187725

chr6_+_28877306 0.04 ENSDART00000065137
ENSDART00000123189
ENSDART00000065135
ENSDART00000181512
ENSDART00000130799
tumor protein p63
chr16_+_37876779 0.02 ENSDART00000140148
si:ch211-198c19.1
chr14_+_46291022 0.01 ENSDART00000074099
calcium binding protein 2b

Network of associatons between targets according to the STRING database.

First level regulatory network of znf148

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 7.6 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.6 4.3 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.5 9.7 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
0.5 1.9 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.4 2.6 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.4 3.2 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.3 1.7 GO:0010754 negative regulation of cGMP-mediated signaling(GO:0010754)
0.3 0.9 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631) regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.3 5.8 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.2 0.7 GO:0035142 hindbrain structural organization(GO:0021577) dorsal fin morphogenesis(GO:0035142) cell motility involved in somitogenic axis elongation(GO:0090247) cell migration involved in somitogenic axis elongation(GO:0090248)
0.2 4.2 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.2 4.7 GO:0030322 stabilization of membrane potential(GO:0030322)
0.2 3.0 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.2 0.7 GO:0006843 mitochondrial citrate transport(GO:0006843)
0.1 1.2 GO:0060036 notochord cell vacuolation(GO:0060036)
0.1 2.7 GO:0045773 positive regulation of axon extension(GO:0045773)
0.1 0.5 GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060368)
0.1 3.8 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.1 0.3 GO:0006526 arginine biosynthetic process(GO:0006526)
0.1 1.2 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.1 2.3 GO:0039020 pronephric nephron tubule development(GO:0039020)
0.1 5.1 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.1 1.0 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.1 1.9 GO:0045332 phospholipid translocation(GO:0045332)
0.1 1.0 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.1 2.6 GO:0048010 vascular endothelial growth factor receptor signaling pathway(GO:0048010)
0.1 3.5 GO:0006414 translational elongation(GO:0006414)
0.0 0.8 GO:0019471 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.0 0.4 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 11.6 GO:0043087 regulation of GTPase activity(GO:0043087)
0.0 0.9 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 1.2 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.2 GO:0097340 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
0.0 5.3 GO:0016042 lipid catabolic process(GO:0016042)
0.0 1.2 GO:0030336 negative regulation of cell migration(GO:0030336)
0.0 0.1 GO:0045687 positive regulation of glial cell differentiation(GO:0045687) positive regulation of oligodendrocyte differentiation(GO:0048714)
0.0 0.5 GO:0014029 neural crest formation(GO:0014029)
0.0 0.1 GO:1900145 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.0 0.2 GO:0045176 asymmetric protein localization(GO:0008105) apical protein localization(GO:0045176)
0.0 1.4 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 0.5 GO:0072175 epithelial tube formation(GO:0072175)
0.0 2.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.5 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.4 2.6 GO:0016234 inclusion body(GO:0016234)
0.3 5.1 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.2 2.7 GO:0044295 axonal growth cone(GO:0044295)
0.2 5.8 GO:0048788 cytoskeleton of presynaptic active zone(GO:0048788)
0.2 2.6 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.1 13.3 GO:0005882 intermediate filament(GO:0005882)
0.1 0.7 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.1 0.9 GO:0031528 microvillus membrane(GO:0031528)
0.1 0.7 GO:0014704 intercalated disc(GO:0014704)
0.1 3.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 5.1 GO:0042383 sarcolemma(GO:0042383)
0.0 1.4 GO:0008305 integrin complex(GO:0008305)
0.0 3.2 GO:0016459 myosin complex(GO:0016459)
0.0 4.2 GO:0008021 synaptic vesicle(GO:0008021)
0.0 5.1 GO:0005912 adherens junction(GO:0005912)
0.0 1.1 GO:0044309 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 1.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.3 GO:0016342 catenin complex(GO:0016342)
0.0 1.9 GO:0045211 postsynaptic membrane(GO:0045211)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.7 GO:0005252 open rectifier potassium channel activity(GO:0005252)
0.8 9.7 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.5 2.7 GO:0008046 axon guidance receptor activity(GO:0008046)
0.4 2.9 GO:0001972 retinoic acid binding(GO:0001972)
0.3 1.7 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.3 4.2 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.2 1.1 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 5.8 GO:0044325 ion channel binding(GO:0044325)
0.1 0.3 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
0.1 3.8 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 3.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 1.5 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 1.0 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 1.0 GO:0031729 CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729)
0.1 1.9 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 3.9 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 2.0 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 5.1 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.8 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 5.8 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 0.4 GO:0005165 nerve growth factor receptor binding(GO:0005163) neurotrophin receptor binding(GO:0005165)
0.0 1.2 GO:0005518 collagen binding(GO:0005518)
0.0 1.2 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 2.7 GO:0045296 cadherin binding(GO:0045296)
0.0 0.2 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0 9.1 GO:0005096 GTPase activator activity(GO:0005096)
0.0 3.4 GO:0003774 motor activity(GO:0003774)
0.0 7.9 GO:0005198 structural molecule activity(GO:0005198)
0.0 1.9 GO:0000287 magnesium ion binding(GO:0000287)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.6 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 2.6 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 1.2 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 1.2 PID SHP2 PATHWAY SHP2 signaling
0.0 0.5 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 9.7 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 8.0 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.2 2.6 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1 0.5 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.1 1.5 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.2 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 1.9 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.2 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 1.1 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.7 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 2.9 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation