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PRJNA195909:zebrafish embryo and larva development

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Results for egr3

Z-value: 0.55

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Transcription factors associated with egr3

Gene Symbol Gene ID Gene Info
egr3
ENSDARG00000089156 early growth response 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
egr3dr11_v1_chr8_+_50727220_50727220-0.353.5e-01Click!

Activity profile of egr3 motif

Sorted Z-values of egr3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_2584423 1.16 ENSDART00000013506
zp3.2
zona pellucida glycoprotein 3, tandem duplicate 2
chr16_-_47381519 1.12 ENSDART00000032188
ENSDART00000150136
si:dkey-256h2.1
si:dkey-256h2.1
chr7_+_46019780 1.11 ENSDART00000163991
ccne1
cyclin E1
chr22_-_10591876 1.10 ENSDART00000105846
si:dkey-42i9.8
si:dkey-42i9.8
chr3_-_49504023 0.82 ENSDART00000168108
prkacaa
protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
chr18_+_3004572 0.71 ENSDART00000190328
CABZ01002690.1

chr13_+_35925490 0.69 ENSDART00000046115
mfsd2aa
major facilitator superfamily domain containing 2aa
chr22_+_34784075 0.63 ENSDART00000167538
lcor
ligand dependent nuclear receptor corepressor
chr21_-_43398122 0.60 ENSDART00000050533
ccni2
cyclin I family, member 2
chr7_-_46019756 0.57 ENSDART00000162583
zgc:162297
zgc:162297
chr22_-_16275236 0.57 ENSDART00000149051
cdc14ab
cell division cycle 14Ab
chr17_+_46387086 0.55 ENSDART00000157079
si:dkey-206p8.1
si:dkey-206p8.1
chr18_+_3169579 0.54 ENSDART00000164724
ENSDART00000186340
ENSDART00000181247
ENSDART00000168056
pak1
p21 protein (Cdc42/Rac)-activated kinase 1
chr21_-_41369539 0.54 ENSDART00000187546
cpeb4b
cytoplasmic polyadenylation element binding protein 4b
chr7_+_55518519 0.53 ENSDART00000098476
ENSDART00000149915
cdt1
chromatin licensing and DNA replication factor 1
chr2_+_38924975 0.53 ENSDART00000109219
rem2
RAS (RAD and GEM)-like GTP binding 2
chr2_+_35880600 0.50 ENSDART00000004277
lamc1
laminin, gamma 1
chr21_-_43398457 0.49 ENSDART00000166530
ccni2
cyclin I family, member 2
chr2_+_23062085 0.48 ENSDART00000153745
csnk1g2a
casein kinase 1, gamma 2a
chr20_+_27712714 0.47 ENSDART00000008306
zbtb1
zinc finger and BTB domain containing 1
chr2_+_105748 0.46 ENSDART00000169601
CABZ01098670.1

chr15_-_14038227 0.44 ENSDART00000139068
zgc:114130
zgc:114130
chr2_+_59015878 0.44 ENSDART00000148816
ENSDART00000122795
si:ch1073-391i24.1
si:ch1073-391i24.1
chr7_+_67325933 0.43 ENSDART00000170575
ENSDART00000183342
nfat5b
nuclear factor of activated T cells 5b
chr21_-_41369370 0.42 ENSDART00000159290
cpeb4b
cytoplasmic polyadenylation element binding protein 4b
chr7_-_6364168 0.42 ENSDART00000173332
zgc:112234
zgc:112234
chr20_+_28803642 0.40 ENSDART00000188526
fntb
farnesyltransferase, CAAX box, beta
chr13_-_49666615 0.38 ENSDART00000148083
tomm20a
translocase of outer mitochondrial membrane 20
chr12_-_26537145 0.35 ENSDART00000138437
ENSDART00000163931
ENSDART00000132737
acsf2
acyl-CoA synthetase family member 2
chr12_-_37449396 0.34 ENSDART00000152951
cdc42ep4b
CDC42 effector protein (Rho GTPase binding) 4b
chr5_+_29831235 0.31 ENSDART00000109660
f11r.1
F11 receptor, tandem duplicate 1
chr11_+_1565806 0.31 ENSDART00000137479
mybl2b
v-myb avian myeloblastosis viral oncogene homolog-like 2b
chr23_-_31645760 0.30 ENSDART00000035031
sgk1
serum/glucocorticoid regulated kinase 1
chr3_+_22984098 0.29 ENSDART00000043190
lsm12a
LSM12 homolog a
chr20_+_27298783 0.26 ENSDART00000013861
ppp4r4
protein phosphatase 4, regulatory subunit 4
chr11_-_2594045 0.26 ENSDART00000114079
nab2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr4_-_73587205 0.24 ENSDART00000150837
znf1015
zinc finger protein 1015
chr1_+_12295142 0.21 ENSDART00000158595
gne
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
chr6_+_2271559 0.21 ENSDART00000165223
pbx1b
pre-B-cell leukemia homeobox 1b
chr7_+_41340520 0.21 ENSDART00000005127
garem
GRB2 associated, regulator of MAPK1
chr5_+_6617401 0.19 ENSDART00000060532
zgc:110796
zgc:110796
chr2_+_16710889 0.19 ENSDART00000017852
ubxn7
UBX domain protein 7
chr21_-_24865217 0.18 ENSDART00000101136
igsf9bb
immunoglobulin superfamily, member 9Bb
chr13_-_36141486 0.14 ENSDART00000044115
med6
mediator complex subunit 6
chr25_-_6389713 0.14 ENSDART00000083539
sin3aa
SIN3 transcription regulator family member Aa
chr3_-_11624694 0.14 ENSDART00000127157
hlfa
hepatic leukemia factor a
chr21_-_217589 0.13 ENSDART00000185017
CZQB01146713.1

chr3_-_7106678 0.13 ENSDART00000175293
ENSDART00000187732
ENSDART00000158652
zgc:113102
BX005085.2
zgc:113102

chr13_-_31166544 0.12 ENSDART00000146250
ENSDART00000132129
ENSDART00000139591
mapk8a
mitogen-activated protein kinase 8a
chr9_-_48036 0.09 ENSDART00000165230
ENSDART00000171335
map4k4
mitogen-activated protein kinase kinase kinase kinase 4
chr5_-_2689753 0.09 ENSDART00000172699
gng10
guanine nucleotide binding protein (G protein), gamma 10
chr16_+_4138331 0.08 ENSDART00000192403
ENSDART00000193036
mtf1
metal-regulatory transcription factor 1
chr12_+_499881 0.08 ENSDART00000167527
mprip
myosin phosphatase Rho interacting protein
chr21_-_24865454 0.08 ENSDART00000142907
igsf9bb
immunoglobulin superfamily, member 9Bb
chr22_+_1806235 0.08 ENSDART00000158966
znf1168
zinc finger protein 1168
chr24_-_39354829 0.06 ENSDART00000169108
kcnj12a
potassium inwardly-rectifying channel, subfamily J, member 12a
chr19_+_5480327 0.06 ENSDART00000148794
jupb
junction plakoglobin b
chr15_+_36105581 0.05 ENSDART00000184099
col4a3
collagen, type IV, alpha 3
chr18_+_41549764 0.04 ENSDART00000059135
bcl7bb
BCL tumor suppressor 7Bb
chr17_+_48164536 0.03 ENSDART00000161750
ENSDART00000156923
plekhd1
pleckstrin homology domain containing, family D (with coiled-coil domains) member 1
chr25_+_1304173 0.02 ENSDART00000155229
rxfp3.3b
relaxin/insulin-like family peptide receptor 3.3b
chr3_-_5228137 0.02 ENSDART00000137105
myh9b
myosin, heavy chain 9b, non-muscle
chr20_+_13894123 0.01 ENSDART00000007744
slc30a1a
solute carrier family 30 (zinc transporter), member 1a
chr6_-_53391727 0.01 ENSDART00000155483
si:ch211-161c3.6
si:ch211-161c3.6
chr19_-_48039400 0.00 ENSDART00000166748
ENSDART00000165921
csf3b
colony stimulating factor 3 (granulocyte) b

Network of associatons between targets according to the STRING database.

First level regulatory network of egr3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0042998 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.2 0.7 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.1 0.4 GO:0018343 protein farnesylation(GO:0018343)
0.1 0.8 GO:0071331 cellular response to carbohydrate stimulus(GO:0071322) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.1 0.5 GO:0003232 bulbus arteriosus development(GO:0003232)
0.1 1.0 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.1 1.2 GO:0007339 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.1 0.6 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.0 2.2 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.5 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.5 GO:0000076 DNA replication checkpoint(GO:0000076)
0.0 0.3 GO:0031274 pseudopodium organization(GO:0031268) pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.3 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.3 GO:0050892 intestinal absorption(GO:0050892)
0.0 0.5 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 0.1 GO:0071276 cellular response to cadmium ion(GO:0071276)
0.0 0.1 GO:0002159 desmosome assembly(GO:0002159)
0.0 0.2 GO:0006047 UDP-N-acetylglucosamine metabolic process(GO:0006047)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
0.1 0.4 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.1 0.6 GO:1902636 kinociliary basal body(GO:1902636)
0.1 0.8 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 1.0 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.4 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 1.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.1 GO:0070847 core mediator complex(GO:0070847)
0.0 0.1 GO:0016580 Sin3 complex(GO:0016580)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.2 0.8 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 0.6 GO:0071253 connexin binding(GO:0071253)
0.1 0.5 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 0.3 GO:0047760 medium-chain fatty acid-CoA ligase activity(GO:0031956) butyrate-CoA ligase activity(GO:0047760)
0.1 1.2 GO:0035804 structural constituent of egg coat(GO:0035804)
0.1 0.4 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.1 0.2 GO:0008761 UDP-N-acetylglucosamine 2-epimerase activity(GO:0008761) N-acylmannosamine kinase activity(GO:0009384)
0.1 1.0 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 2.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.5 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.7 GO:0005548 phospholipid transporter activity(GO:0005548)
0.0 0.1 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.5 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.5 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 0.6 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 1.6 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription