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PRJNA195909:zebrafish embryo and larva development

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Results for hmga1a

Z-value: 0.68

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Transcription factors associated with hmga1a

Gene Symbol Gene ID Gene Info
hmga1a
ENSDARG00000028335 high mobility group AT-hook 1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hmga1adr11_v1_chr23_-_3759692_37596920.742.4e-02Click!

Activity profile of hmga1a motif

Sorted Z-values of hmga1a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_20195350 0.73 ENSDART00000139675
dao.1
D-amino-acid oxidase, tandem duplicate 1
chr25_-_34670413 0.68 ENSDART00000073440
DNAJA4
DnaJ heat shock protein family (Hsp40) member A4
chr12_-_656540 0.66 ENSDART00000172651
sult2st2
sulfotransferase family 2, cytosolic sulfotransferase 2
chr3_+_62161184 0.61 ENSDART00000090370
ENSDART00000192665
noxo1a
NADPH oxidase organizer 1a
chr23_-_45439903 0.59 ENSDART00000170729
NPNT (1 of many)
nephronectin
chr16_+_1383914 0.59 ENSDART00000185089
cers2b
ceramide synthase 2b
chr8_-_50981175 0.54 ENSDART00000004065
zgc:91909
zgc:91909
chr23_+_25354856 0.53 ENSDART00000109023
ENSDART00000147440
fmnl3
formin-like 3
chr15_-_29387446 0.50 ENSDART00000145976
ENSDART00000035096
serpinh1b
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b
chr12_-_10409961 0.50 ENSDART00000149521
ENSDART00000052001
eef2k
eukaryotic elongation factor 2 kinase
chr7_+_33130639 0.46 ENSDART00000142450
ENSDART00000173967
ENSDART00000173832
zgc:153219
si:ch211-194p6.7
zgc:153219
si:ch211-194p6.7
chr16_-_29557338 0.45 ENSDART00000058888
hormad1
HORMA domain containing 1
chr6_-_58764672 0.44 ENSDART00000154322
soat2
sterol O-acyltransferase 2
chr23_-_28347039 0.43 ENSDART00000145072
neurod4
neuronal differentiation 4
chr5_-_38451082 0.40 ENSDART00000136428
chrne
cholinergic receptor, nicotinic, epsilon
chr21_+_22845317 0.38 ENSDART00000065555
birc2
baculoviral IAP repeat containing 2
chr2_+_25839193 0.38 ENSDART00000078634
eif5a2
eukaryotic translation initiation factor 5A2
chr20_+_34400715 0.36 ENSDART00000061632
fam129aa
family with sequence similarity 129, member Aa
chr7_-_22956716 0.34 ENSDART00000122113
tnfsf10l
TNF superfamily member 10, like
chr7_-_22956889 0.34 ENSDART00000101447
tnfsf10l
TNF superfamily member 10, like
chr17_-_40110782 0.32 ENSDART00000126929
si:dkey-187k19.2
si:dkey-187k19.2
chr11_-_16975190 0.30 ENSDART00000122222
suclg2
succinate-CoA ligase, GDP-forming, beta subunit
chr5_+_32831561 0.29 ENSDART00000169358
ENSDART00000192078
si:ch211-208h16.4
si:ch211-208h16.4
chr16_+_2433696 0.29 ENSDART00000182803
CU928063.1

chr18_+_14595546 0.28 ENSDART00000080788
wfdc1
WAP four-disulfide core domain 1
chr6_-_58757131 0.28 ENSDART00000083582
soat2
sterol O-acyltransferase 2
chr15_+_47440477 0.27 ENSDART00000002384
phox2a
paired-like homeobox 2a
chr23_-_45407631 0.25 ENSDART00000148484
ENSDART00000150186
zgc:101853
zgc:101853
chr9_+_25568839 0.24 ENSDART00000177342
zeb2a
zinc finger E-box binding homeobox 2a
chr7_+_15871156 0.24 ENSDART00000145946
pax6b
paired box 6b
chr17_+_51520073 0.23 ENSDART00000189646
ENSDART00000170951
ENSDART00000189492
pxdn
peroxidasin
chr13_+_49175947 0.23 ENSDART00000056927
egln1a
egl-9 family hypoxia-inducible factor 1a
chr12_-_36740781 0.23 ENSDART00000105484
si:ch211-216b21.2
si:ch211-216b21.2
chr25_+_581227 0.23 ENSDART00000126863
nell2a
neural EGFL like 2a
chr7_-_16558665 0.22 ENSDART00000169399
csrp3
cysteine and glycine-rich protein 3 (cardiac LIM protein)
chr11_+_37095165 0.22 ENSDART00000124997
card19
caspase recruitment domain family, member 19
chr13_+_49175624 0.21 ENSDART00000193550
egln1a
egl-9 family hypoxia-inducible factor 1a
chr23_+_45512825 0.21 ENSDART00000064846
prelid1b
PRELI domain containing 1b
chr17_-_5769196 0.20 ENSDART00000113885
si:dkey-100n19.2
si:dkey-100n19.2
chr4_+_17245217 0.20 ENSDART00000184215
ENSDART00000110908
casc1
cancer susceptibility candidate 1
chr4_+_65537216 0.19 ENSDART00000181458
si:dkey-205i10.1
si:dkey-205i10.1
chr14_-_33521071 0.19 ENSDART00000052789
c1galt1c1
C1GALT1-specific chaperone 1
chr4_+_17245005 0.19 ENSDART00000027645
casc1
cancer susceptibility candidate 1
chr23_-_27633730 0.18 ENSDART00000103639
arf3a
ADP-ribosylation factor 3a
chr18_+_14595805 0.18 ENSDART00000167825
wfdc1
WAP four-disulfide core domain 1
chr10_+_42733210 0.17 ENSDART00000189832
CABZ01063556.1

chr24_-_35534273 0.17 ENSDART00000026578
ube2v2
ubiquitin-conjugating enzyme E2 variant 2
chr21_-_20765338 0.17 ENSDART00000135940
ghrb
growth hormone receptor b
chr13_+_1089942 0.17 ENSDART00000054322
cnrip1b
cannabinoid receptor interacting protein 1b
chr6_+_22679610 0.16 ENSDART00000102701
zmp:0000000634
zmp:0000000634
chr13_+_41917606 0.16 ENSDART00000114741
polr1b
polymerase (RNA) I polypeptide B
chr17_-_21200406 0.16 ENSDART00000104708
abhd12
abhydrolase domain containing 12
chr14_-_38827442 0.15 ENSDART00000160000
spdl1
spindle apparatus coiled-coil protein 1
chr19_+_29808471 0.15 ENSDART00000186428
hdac1
histone deacetylase 1
chr8_+_49975160 0.15 ENSDART00000156403
ENSDART00000080135
gfpt1
glutamine--fructose-6-phosphate transaminase 1
chr11_-_4235811 0.14 ENSDART00000121716
si:ch211-236d3.4
si:ch211-236d3.4
chr16_-_12236362 0.14 ENSDART00000114759
lpcat3
lysophosphatidylcholine acyltransferase 3
chr18_+_328689 0.14 ENSDART00000167841
ss18l2
synovial sarcoma translocation gene on chromosome 18-like 2
chr8_+_40644838 0.14 ENSDART00000169311
adra2b
adrenoceptor alpha 2B
chr19_+_29808699 0.13 ENSDART00000051799
ENSDART00000164205
hdac1
histone deacetylase 1
chr20_+_26349002 0.13 ENSDART00000152842
syne1a
spectrin repeat containing, nuclear envelope 1a
chr5_-_20814576 0.13 ENSDART00000098682
ENSDART00000147639
si:ch211-225b11.1
si:ch211-225b11.1
chr24_-_29963858 0.13 ENSDART00000183442
CR352310.1

chr15_+_888704 0.13 ENSDART00000182796
si:dkey-7i4.9
si:dkey-7i4.9
chr24_-_18477672 0.13 ENSDART00000126928
ENSDART00000158393
si:dkey-73n8.3
si:dkey-73n8.3
chr16_-_42969598 0.13 ENSDART00000156011
si:ch211-135n15.3
si:ch211-135n15.3
chr3_+_26019426 0.12 ENSDART00000135389
ENSDART00000182411
foxred2
FAD-dependent oxidoreductase domain containing 2
chr3_+_36515376 0.12 ENSDART00000161652
si:dkeyp-72e1.9
si:dkeyp-72e1.9
chr4_-_992063 0.12 ENSDART00000181630
ENSDART00000183898
ENSDART00000160902
naga
N-acetylgalactosaminidase, alpha
chr7_+_48999723 0.11 ENSDART00000182699
ENSDART00000166329
si:ch211-288d18.1
si:ch211-288d18.1
chr24_-_31306724 0.10 ENSDART00000165399
acp5b
acid phosphatase 5b, tartrate resistant
chr11_-_12051502 0.10 ENSDART00000183462
socs7
suppressor of cytokine signaling 7
chr11_-_12051283 0.09 ENSDART00000170516
socs7
suppressor of cytokine signaling 7
chr6_-_2222707 0.09 ENSDART00000022179
prkag1
protein kinase, AMP-activated, gamma 1 non-catalytic subunit
chr6_-_7123210 0.08 ENSDART00000041304
atg3
autophagy related 3
chr10_-_1726148 0.08 ENSDART00000187527
gal3st1b
galactose-3-O-sulfotransferase 1b
chr14_-_38828057 0.08 ENSDART00000186088
spdl1
spindle apparatus coiled-coil protein 1
chr5_+_20421539 0.08 ENSDART00000164499
selplg
selectin P ligand
chr4_+_72668095 0.07 ENSDART00000182282
ENSDART00000162637
CABZ01054391.1

chr4_-_45028479 0.07 ENSDART00000143150
ENSDART00000076870
si:dkey-51d8.1
si:dkey-51d8.1
chr10_-_1725699 0.07 ENSDART00000183555
gal3st1b
galactose-3-O-sulfotransferase 1b
chr21_+_7545062 0.07 ENSDART00000023997
tbca
tubulin cofactor a
chr8_-_42579446 0.06 ENSDART00000189792
dok2
docking protein 2
chr12_-_44196222 0.06 ENSDART00000171730
si:ch73-329n5.1
si:ch73-329n5.1
chr14_+_8710568 0.06 ENSDART00000169505
kcnk4a
potassium channel, subfamily K, member 4a
chr5_-_66296635 0.06 ENSDART00000125993
prlrb
prolactin receptor b
chr14_+_46020571 0.05 ENSDART00000157617
ENSDART00000083928
c1qtnf2
C1q and TNF related 2
chr4_+_13568469 0.05 ENSDART00000171235
ENSDART00000136152
calua
calumenin a
chr1_+_2112726 0.05 ENSDART00000131714
ENSDART00000138396
mbnl2
muscleblind-like splicing regulator 2
chr17_-_15201031 0.05 ENSDART00000124426
socs4
suppressor of cytokine signaling 4
chr6_+_8630355 0.05 ENSDART00000161749
ENSDART00000193976
tspeara
thrombospondin-type laminin G domain and EAR repeats a
chr1_+_44360973 0.05 ENSDART00000167568
si:ch211-165a10.5
si:ch211-165a10.5
chr5_-_51830997 0.05 ENSDART00000163616
homer1b
homer scaffolding protein 1b
chr15_+_17030941 0.04 ENSDART00000062069
plin2
perilipin 2
chr15_+_17030473 0.04 ENSDART00000129407
plin2
perilipin 2
chr7_-_33130552 0.04 ENSDART00000127006
mns1
meiosis-specific nuclear structural 1
chr12_+_46512881 0.04 ENSDART00000105454
CU855711.1

chr8_-_53735399 0.04 ENSDART00000187005
tlr9
toll-like receptor 9
chr2_-_10062575 0.03 ENSDART00000091726
fam78ba
family with sequence similarity 78, member B a
chr17_+_31739418 0.03 ENSDART00000155073
ENSDART00000156180
arhgap5
Rho GTPase activating protein 5
chr16_+_11652591 0.03 ENSDART00000133876
si:dkey-250k15.9
si:dkey-250k15.9
chr16_+_11724230 0.03 ENSDART00000060266
ceacam1
carcinoembryonic antigen-related cell adhesion molecule 1
chr9_-_12885201 0.03 ENSDART00000124957
ankzf1
ankyrin repeat and zinc finger domain containing 1
chr25_-_2355107 0.02 ENSDART00000056121
mrps35
mitochondrial ribosomal protein S35
chr12_+_46483618 0.02 ENSDART00000186970
BX005305.5

chr21_+_40302747 0.02 ENSDART00000174166
si:ch211-218m3.18
si:ch211-218m3.18
chr12_+_46425800 0.02 ENSDART00000191965
BX005305.1

chr15_+_44135726 0.02 ENSDART00000192151
CU655961.2

chr18_-_35407289 0.01 ENSDART00000012018
snrpa
small nuclear ribonucleoprotein polypeptide A
chr14_+_46020282 0.01 ENSDART00000190087
c1qtnf2
C1q and TNF related 2
chr14_+_34951202 0.01 ENSDART00000047524
ENSDART00000115105
il12ba
interleukin 12Ba
chr6_+_3827751 0.01 ENSDART00000003008
ENSDART00000122348
gad1b
glutamate decarboxylase 1b
chr6_-_48094342 0.01 ENSDART00000137458
slc2a1b
solute carrier family 2 (facilitated glucose transporter), member 1b
chr22_-_10580194 0.01 ENSDART00000105848
SHISA4 (1 of many)
si:dkey-42i9.7
chr1_+_19849168 0.01 ENSDART00000111454
si:dkey-82j4.2
si:dkey-82j4.2
chr18_-_46380471 0.01 ENSDART00000144444
ENSDART00000086772
slc19a3b
solute carrier family 19 (thiamine transporter), member 3b
chr14_-_15699528 0.00 ENSDART00000161123
neurl1b
neuralized E3 ubiquitin protein ligase 1B

Network of associatons between targets according to the STRING database.

First level regulatory network of hmga1a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0046144 alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080) D-alanine family amino acid metabolic process(GO:0046144) D-alanine metabolic process(GO:0046436) D-alanine catabolic process(GO:0055130)
0.1 0.5 GO:0033313 meiotic cell cycle checkpoint(GO:0033313)
0.1 0.4 GO:0060547 negative regulation of necroptotic process(GO:0060546) negative regulation of necrotic cell death(GO:0060547)
0.1 0.7 GO:0034435 steroid esterification(GO:0034433) sterol esterification(GO:0034434) cholesterol esterification(GO:0034435)
0.1 0.7 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.1 0.4 GO:0001839 neural plate morphogenesis(GO:0001839)
0.1 0.2 GO:0035994 response to muscle stretch(GO:0035994)
0.1 0.4 GO:0045905 positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.0 0.2 GO:0016267 O-glycan processing, core 1(GO:0016267)
0.0 0.3 GO:0033687 osteoblast proliferation(GO:0033687)
0.0 0.2 GO:0090243 fibroblast growth factor receptor signaling pathway involved in somitogenesis(GO:0090243)
0.0 0.2 GO:0003311 pancreatic D cell differentiation(GO:0003311) pancreatic epsilon cell differentiation(GO:0090104)
0.0 0.5 GO:0061300 cerebellum vasculature development(GO:0061300)
0.0 0.2 GO:0052651 phosphatidylserine catabolic process(GO:0006660) monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.0 0.2 GO:0071459 protein localization to kinetochore(GO:0034501) protein localization to chromosome, centromeric region(GO:0071459)
0.0 0.1 GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881)
0.0 0.3 GO:0021703 locus ceruleus development(GO:0021703)
0.0 0.7 GO:0051923 sulfation(GO:0051923)
0.0 0.4 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.0 0.6 GO:0006801 superoxide metabolic process(GO:0006801)
0.0 0.1 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.4 GO:0007271 synaptic transmission, cholinergic(GO:0007271)
0.0 0.1 GO:0050775 positive regulation of dendrite morphogenesis(GO:0050775)
0.0 0.2 GO:2000272 negative regulation of receptor activity(GO:2000272)
0.0 0.1 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.0 0.1 GO:0016137 glycoside metabolic process(GO:0016137) glycoside catabolic process(GO:0016139)
0.0 0.1 GO:0038161 prolactin signaling pathway(GO:0038161)
0.0 0.1 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.5 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.2 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) response to growth hormone(GO:0060416) cellular response to growth hormone stimulus(GO:0071378)
0.0 0.5 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.0 GO:0071706 tumor necrosis factor production(GO:0032640) tumor necrosis factor superfamily cytokine production(GO:0071706)
0.0 0.1 GO:0097241 hematopoietic stem cell migration to bone marrow(GO:0097241)
0.0 0.1 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.2 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 0.6 GO:0046513 ceramide biosynthetic process(GO:0046513)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0042709 succinate-CoA ligase complex(GO:0042709)
0.0 0.2 GO:0070195 growth hormone receptor complex(GO:0070195)
0.0 0.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0003884 D-amino-acid oxidase activity(GO:0003884)
0.2 0.7 GO:0034736 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.1 0.3 GO:0004775 succinate-CoA ligase activity(GO:0004774) succinate-CoA ligase (ADP-forming) activity(GO:0004775) succinate-CoA ligase (GDP-forming) activity(GO:0004776)
0.1 0.6 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.2 GO:0048531 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263) beta-1,3-galactosyltransferase activity(GO:0048531)
0.0 0.2 GO:0004903 growth hormone receptor activity(GO:0004903)
0.0 0.6 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.1 GO:0004557 alpha-galactosidase activity(GO:0004557)
0.0 0.1 GO:0070548 L-glutamine aminotransferase activity(GO:0070548)
0.0 0.2 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.0 0.4 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.0 0.1 GO:0019777 Atg12 transferase activity(GO:0019777)
0.0 0.1 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0 0.2 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.2 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.1 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.0 0.4 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.3 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.7 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.5 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.9 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.4 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.1 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.1 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.1 GO:0004925 prolactin receptor activity(GO:0004925)
0.0 0.5 GO:0005518 collagen binding(GO:0005518)
0.0 0.1 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 0.2 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.2 GO:0047372 acylglycerol lipase activity(GO:0047372)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.4 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.3 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.4 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.1 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.1 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.3 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.3 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.4 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.4 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 0.1 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors