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PRJNA195909:zebrafish embryo and larva development

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Results for klf3+klf8

Z-value: 1.18

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Transcription factors associated with klf3+klf8

Gene Symbol Gene ID Gene Info
klf3
ENSDARG00000015495 Kruppel-like factor 3 (basic)
klf8
ENSDARG00000060661 Kruppel-like factor 8
klf3
ENSDARG00000114143 Kruppel-like factor 3 (basic)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
klf8dr11_v1_chr21_+_38073210_38073216-0.932.9e-04Click!
klf3dr11_v1_chr1_-_18615063_186150630.844.4e-03Click!

Activity profile of klf3+klf8 motif

Sorted Z-values of klf3+klf8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_2039060 3.36 ENSDART00000173879
si:cabz01007794.1
si:cabz01007794.1
chr2_-_35566938 3.35 ENSDART00000029006
ENSDART00000077178
ENSDART00000125298
tnn
tenascin N
chr10_-_22797959 3.29 ENSDART00000183269
pcolcea
procollagen C-endopeptidase enhancer a
chr15_+_29085955 3.01 ENSDART00000156799
si:ch211-137a8.4
si:ch211-137a8.4
chr16_+_23978978 2.85 ENSDART00000058964
ENSDART00000135084
apoa2
apolipoprotein A-II
chr1_-_44940830 2.84 ENSDART00000097500
ENSDART00000134464
ENSDART00000137216
tmem176
transmembrane protein 176
chr18_-_46010 2.48 ENSDART00000052641
gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr13_+_681628 2.25 ENSDART00000016604
abcc2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr14_+_13453130 2.07 ENSDART00000054849
pls3
plastin 3 (T isoform)
chr24_-_40667800 2.06 ENSDART00000169315
smyhc1
slow myosin heavy chain 1
chr4_-_193762 2.04 ENSDART00000169667
ptpro
protein tyrosine phosphatase, receptor type, O
chr24_-_40668208 1.88 ENSDART00000171543
smyhc1
slow myosin heavy chain 1
chr1_-_625875 1.70 ENSDART00000167331
appa
amyloid beta (A4) precursor protein a
chr13_-_992458 1.52 ENSDART00000114655
BFSP1
beaded filament structural protein 1
chr4_-_191736 1.39 ENSDART00000169187
ENSDART00000192054
ptpro
protein tyrosine phosphatase, receptor type, O
chr1_+_44941031 1.31 ENSDART00000141145
si:dkey-9i23.16
si:dkey-9i23.16
chr6_-_57655030 1.23 ENSDART00000155438
cbfa2t2
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
chr19_+_56351 1.15 ENSDART00000168334
col14a1b
collagen, type XIV, alpha 1b
chr10_+_4875262 1.12 ENSDART00000165942
palm2
paralemmin 2
chr7_+_35229645 1.12 ENSDART00000144327
tppp3
tubulin polymerization-promoting protein family member 3
chr18_+_54354 1.05 ENSDART00000097163
zgc:158482
zgc:158482
chr3_-_32927516 1.04 ENSDART00000140117
aoc2
amine oxidase, copper containing 2
chr6_+_120181 0.99 ENSDART00000151209
ENSDART00000185930
cdkn2d
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr19_+_19786117 0.94 ENSDART00000167757
ENSDART00000163546
hoxa1a
homeobox A1a
chr6_+_41181869 0.93 ENSDART00000002046
opn1mw1
opsin 1 (cone pigments), medium-wave-sensitive, 1
chr1_-_49434798 0.92 ENSDART00000150842
ENSDART00000150789
ATP5MD
si:dkeyp-80c12.10
chr3_-_1190132 0.91 ENSDART00000149709
smdt1a
single-pass membrane protein with aspartate-rich tail 1a
chr10_+_4874542 0.91 ENSDART00000101431
palm2
paralemmin 2
chr21_-_35832548 0.89 ENSDART00000180840
sgcd
sarcoglycan, delta (dystrophin-associated glycoprotein)
chr19_+_233143 0.88 ENSDART00000175273
syngap1a
synaptic Ras GTPase activating protein 1a
chr2_-_30135446 0.86 ENSDART00000141906
trpa1a
transient receptor potential cation channel, subfamily A, member 1a
chr19_-_677713 0.85 ENSDART00000025146
slc6a19a.1
solute carrier family 6 (neutral amino acid transporter), member 19a, tandem duplicate 1
chr5_-_64213253 0.85 ENSDART00000171711
gpsm1a
G protein signaling modulator 1a
chr21_+_44857293 0.82 ENSDART00000134365
ENSDART00000168217
ENSDART00000065083
fstl4
follistatin-like 4
chr24_+_81527 0.82 ENSDART00000192139
reck
reversion-inducing-cysteine-rich protein with kazal motifs
chr24_-_14212521 0.79 ENSDART00000130825
xkr9
XK, Kell blood group complex subunit-related family, member 9
chr25_+_23489979 0.77 ENSDART00000158200
CU024870.1

chr19_+_164013 0.74 ENSDART00000167379
carmil1
capping protein regulator and myosin 1 linker 1
chr16_+_44768361 0.72 ENSDART00000036302
upk1a
uroplakin 1a
chr21_+_17542473 0.72 ENSDART00000005750
ENSDART00000141326
stom
stomatin
chr14_-_21218891 0.67 ENSDART00000158294
ppp2r2cb
protein phosphatase 2, regulatory subunit B, gamma b
chr11_+_37278457 0.66 ENSDART00000188946
creld1a
cysteine-rich with EGF-like domains 1a
chr7_+_35229805 0.62 ENSDART00000173911
tppp3
tubulin polymerization-promoting protein family member 3
chr23_-_45049044 0.62 ENSDART00000067630
SH3GL2 (1 of many)
SH3 domain containing GRB2 like 2, endophilin A1
chr3_-_15444396 0.60 ENSDART00000104361
si:dkey-56d12.4
si:dkey-56d12.4
chr5_-_69041102 0.59 ENSDART00000161561
ank1a
ankyrin 1, erythrocytic a
chr20_-_54377933 0.59 ENSDART00000182664
entpd5b
ectonucleoside triphosphate diphosphohydrolase 5b
chr9_-_11551608 0.58 ENSDART00000128629
fev
FEV (ETS oncogene family)
chr1_-_59571758 0.58 ENSDART00000193546
ENSDART00000167087
wfikkn1
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
chr8_+_28065803 0.57 ENSDART00000178481
kcnd3
potassium voltage-gated channel, Shal-related subfamily, member 3
chr6_+_4084739 0.56 ENSDART00000087661
sema5bb
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Bb
chr18_-_45617146 0.55 ENSDART00000146543
wt1b
wilms tumor 1b
chr9_-_12760323 0.54 ENSDART00000146265
myo10l3
myosin X-like 3
chr20_-_52902693 0.52 ENSDART00000166115
ENSDART00000161050
ctsbb
cathepsin Bb
chr13_-_40238813 0.52 ENSDART00000044963
loxl4
lysyl oxidase-like 4
chr18_-_40508528 0.52 ENSDART00000185249
chrna5
cholinergic receptor, nicotinic, alpha 5
chr7_-_19600181 0.48 ENSDART00000100757
oxa1l
oxidase (cytochrome c) assembly 1-like
chr5_-_29587351 0.47 ENSDART00000136446
ENSDART00000051434
entpd2a.1
ectonucleoside triphosphate diphosphohydrolase 2a, tandem duplicate 1
chr8_+_54013199 0.46 ENSDART00000158497
CABZ01079663.1

chr21_+_27448856 0.45 ENSDART00000100784
cfbl
complement factor b-like
chr23_-_45439903 0.45 ENSDART00000170729
NPNT (1 of many)
nephronectin
chr21_+_11244068 0.45 ENSDART00000163432
arid6
AT-rich interaction domain 6
chr5_-_24174956 0.45 ENSDART00000137631
si:ch211-137i24.10
si:ch211-137i24.10
chr23_-_1017605 0.45 ENSDART00000138290
cdh26.1
cadherin 26, tandem duplicate 1
chr16_-_20492799 0.42 ENSDART00000014769
chn2
chimerin 2
chr8_-_34762163 0.41 ENSDART00000114080
setd1bb
SET domain containing 1B, b
chr10_-_20637098 0.38 ENSDART00000080391
sprn2
shadow of prion protein 2
chr25_+_37348730 0.37 ENSDART00000156639
pamr1
peptidase domain containing associated with muscle regeneration 1
chr23_+_9057999 0.37 ENSDART00000091899
ccm2l
cerebral cavernous malformation 2-like
chr3_+_55093581 0.36 ENSDART00000101709
hbaa2
hemoglobin, alpha adult 2
chr1_+_57235896 0.35 ENSDART00000152621
si:dkey-27j5.7
si:dkey-27j5.7
chr18_-_24988645 0.35 ENSDART00000136434
ENSDART00000085735
chd2
chromodomain helicase DNA binding protein 2
chr23_-_1017428 0.34 ENSDART00000110588
ENSDART00000183158
cdh26.1
cadherin 26, tandem duplicate 1
chr20_+_54356272 0.31 ENSDART00000145735
znf410
zinc finger protein 410
chr7_-_67316903 0.31 ENSDART00000159408
psmd7
proteasome 26S subunit, non-ATPase 7
chr4_+_54618332 0.30 ENSDART00000171824
si:ch211-227e10.2
si:ch211-227e10.2
chr6_-_52757276 0.30 ENSDART00000159154
AL954861.2

chr4_+_50401133 0.29 ENSDART00000150644
si:dkey-156k2.7
si:dkey-156k2.7
chr6_-_39344259 0.28 ENSDART00000104074
zgc:158846
zgc:158846
chr23_-_44233408 0.27 ENSDART00000149318
ENSDART00000085528
zgc:158659
zgc:158659
chr12_+_34763795 0.26 ENSDART00000153097
slc38a10
solute carrier family 38, member 10
chr21_-_280769 0.26 ENSDART00000157753
plgrkt
plasminogen receptor, C-terminal lysine transmembrane protein
chr12_+_19030391 0.25 ENSDART00000153927
si:ch73-139e5.2
si:ch73-139e5.2
chr25_+_16731802 0.25 ENSDART00000188715
BX004976.1

chr8_-_44868020 0.24 ENSDART00000142712
cacna1fa
calcium channel, voltage-dependent, L type, alpha 1F subunit a
chr10_+_15106808 0.22 ENSDART00000141588
scpp8
secretory calcium-binding phosphoprotein 8
chr6_+_41186320 0.22 ENSDART00000025241
opn1mw2
opsin 1 (cone pigments), medium-wave-sensitive, 2
chr4_+_53976731 0.22 ENSDART00000165813
si:ch211-249c2.1
si:ch211-249c2.1
chr7_-_32599669 0.22 ENSDART00000173752
kcna4
potassium voltage-gated channel, shaker-related subfamily, member 4
chr1_+_36194761 0.21 ENSDART00000053773
ENSDART00000147458
lsm6
LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
chr19_-_24218942 0.21 ENSDART00000189198
BX547993.2

chr12_+_48851381 0.21 ENSDART00000187241
ENSDART00000187796
dlg5b.1
discs, large homolog 5b (Drosophila), tandem duplicate 1
chr8_-_1973220 0.18 ENSDART00000184435
si:dkey-178e17.1
si:dkey-178e17.1
chr7_-_67317119 0.18 ENSDART00000183915
psmd7
proteasome 26S subunit, non-ATPase 7
chr8_-_30204650 0.16 ENSDART00000133209
zgc:162939
zgc:162939
chr21_-_29197700 0.13 ENSDART00000172614
si:ch211-57b15.2
si:ch211-57b15.2
chr18_+_5549672 0.12 ENSDART00000184970
nnt2
nicotinamide nucleotide transhydrogenase 2
chr7_-_6351021 0.12 ENSDART00000159542
zgc:112234
zgc:112234
chr14_-_48260744 0.12 ENSDART00000183955
rxfp1
relaxin/insulin-like family peptide receptor 1
chr1_-_53407087 0.12 ENSDART00000157910
elmod2
ELMO/CED-12 domain containing 2
chr22_-_10019768 0.11 ENSDART00000162077
BX324216.2

chr18_+_814328 0.10 ENSDART00000157801
ENSDART00000188492
ENSDART00000184489
fam219b
family with sequence similarity 219, member B
chr5_-_35953472 0.08 ENSDART00000143448
rxfp2l
relaxin/insulin-like family peptide receptor 2, like
chr19_+_7847920 0.08 ENSDART00000132454
si:dkeyp-85e10.1
si:dkeyp-85e10.1
chr22_-_30948457 0.07 ENSDART00000139887
ssuh2.1
ssu-2 homolog, tandem duplicate 1
chr2_-_16217344 0.06 ENSDART00000152031
arhgef4
Rho guanine nucleotide exchange factor (GEF) 4
chr15_-_47822597 0.05 ENSDART00000193236
ENSDART00000161391
CZQB01095947.1

chr18_+_7309150 0.04 ENSDART00000052792
cers3b
ceramide synthase 3b
chr9_-_56459660 0.03 ENSDART00000162771
ubxn4
UBX domain protein 4
chr22_-_8594846 0.02 ENSDART00000081690
ENSDART00000192241
si:ch73-27e22.1
si:ch73-27e22.1
chr11_-_8269227 0.02 ENSDART00000127202
ENSDART00000158079
ENSDART00000158748
si:cabz01021067.1
pimr202
si:cabz01021067.1
Pim proto-oncogene, serine/threonine kinase, related 202
chr9_-_56420087 0.01 ENSDART00000112016
actr3
ARP3 actin related protein 3 homolog
chr16_-_50918908 0.01 ENSDART00000108744
CU855821.1

chr22_-_16412496 0.00 ENSDART00000137497
cts12
cathepsin 12

Network of associatons between targets according to the STRING database.

First level regulatory network of klf3+klf8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0006600 creatine metabolic process(GO:0006600) creatine biosynthetic process(GO:0006601)
0.6 3.9 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.3 0.8 GO:1905048 regulation of metallopeptidase activity(GO:1905048)
0.2 0.7 GO:2000812 regulation of barbed-end actin filament capping(GO:2000812)
0.2 0.9 GO:0050955 thermoception(GO:0050955) detection of temperature stimulus involved in thermoception(GO:0050960) detection of temperature stimulus involved in sensory perception(GO:0050961)
0.2 0.6 GO:0071435 potassium ion export(GO:0071435) potassium ion export across plasma membrane(GO:0097623)
0.1 0.5 GO:0051204 protein insertion into membrane from inner side(GO:0032978) protein insertion into mitochondrial membrane from inner side(GO:0032979) protein insertion into mitochondrial membrane(GO:0051204)
0.1 2.1 GO:0051639 actin filament network formation(GO:0051639)
0.1 3.4 GO:0021587 cerebellum morphogenesis(GO:0021587)
0.1 0.9 GO:0007525 somatic muscle development(GO:0007525)
0.1 0.8 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.1 0.7 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.1 0.3 GO:0010755 regulation of plasminogen activation(GO:0010755)
0.1 1.1 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.1 0.9 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 1.7 GO:0046785 microtubule polymerization(GO:0046785)
0.0 0.2 GO:0006843 mitochondrial citrate transport(GO:0006843)
0.0 0.5 GO:0035094 response to nicotine(GO:0035094)
0.0 0.1 GO:0006740 NADPH regeneration(GO:0006740)
0.0 2.8 GO:0055113 epiboly involved in gastrulation with mouth forming second(GO:0055113)
0.0 0.5 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.0 3.3 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 1.1 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.5 GO:0021551 central nervous system morphogenesis(GO:0021551)
0.0 0.5 GO:0048246 macrophage chemotaxis(GO:0048246)
0.0 2.3 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 0.4 GO:0015671 oxygen transport(GO:0015671)
0.0 0.4 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.2 GO:0030819 activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762)
0.0 0.3 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 1.0 GO:0009308 amine metabolic process(GO:0009308)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:1990909 Wnt signalosome(GO:1990909)
0.1 0.9 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 0.9 GO:1990246 uniplex complex(GO:1990246)
0.0 4.5 GO:0016459 myosin complex(GO:0016459)
0.0 2.1 GO:0032432 actin filament bundle(GO:0032432)
0.0 0.4 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.3 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.3 GO:0045095 keratin filament(GO:0045095)
0.0 1.1 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.4 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.2 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.5 GO:0005838 proteasome regulatory particle(GO:0005838)
0.0 2.3 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.8 GO:0016342 catenin complex(GO:0016342)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 1.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.6 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 2.5 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.1 1.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.1 1.1 GO:0045134 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.1 3.3 GO:0005178 integrin binding(GO:0005178)
0.1 0.5 GO:0032977 membrane insertase activity(GO:0032977)
0.0 0.1 GO:0016652 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.0 0.5 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.4 GO:0031720 haptoglobin binding(GO:0031720)
0.0 0.9 GO:0015278 calcium-release channel activity(GO:0015278)
0.0 0.5 GO:0070122 isopeptidase activity(GO:0070122)
0.0 0.3 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.0 1.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.5 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.2 GO:0030955 potassium ion binding(GO:0030955) alkali metal ion binding(GO:0031420)
0.0 4.5 GO:0003774 motor activity(GO:0003774)
0.0 1.7 GO:0008201 heparin binding(GO:0008201)
0.0 3.0 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 2.3 GO:0042626 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 3.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.4 PID RAC1 REG PATHWAY Regulation of RAC1 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.8 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 2.3 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.1 0.5 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.2 REACTOME OPSINS Genes involved in Opsins
0.0 1.0 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.8 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 3.0 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.2 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease