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PRJNA195909:zebrafish embryo and larva development

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Results for nr6a1b

Z-value: 1.07

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Transcription factors associated with nr6a1b

Gene Symbol Gene ID Gene Info
nr6a1b
ENSDARG00000014480 nuclear receptor subfamily 6, group A, member 1b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nr6a1bdr11_v1_chr21_+_8239544_8239544-0.166.7e-01Click!

Activity profile of nr6a1b motif

Sorted Z-values of nr6a1b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_37210397 1.53 ENSDART00000084938
apoda.1
apolipoprotein Da, duplicate 1
chr3_-_7656059 1.34 ENSDART00000170917
junbb
JunB proto-oncogene, AP-1 transcription factor subunit b
chr16_-_45235947 1.22 ENSDART00000164436
si:dkey-33i11.4
si:dkey-33i11.4
chr4_-_17409533 1.21 ENSDART00000011943
pah
phenylalanine hydroxylase
chr3_+_13469704 1.17 ENSDART00000166806
zgc:77748
zgc:77748
chr19_-_5135345 1.17 ENSDART00000151787
gnb3b
guanine nucleotide binding protein (G protein), beta polypeptide 3b
chr1_-_55785722 1.16 ENSDART00000142069
ENSDART00000043933
ndufb7
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7
chr20_+_10539293 1.16 ENSDART00000182265
serpina1l
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, like
chr12_-_30583668 1.07 ENSDART00000153406
casp7
caspase 7, apoptosis-related cysteine peptidase
chr5_-_28606916 1.01 ENSDART00000026107
ENSDART00000137717
tnc
tenascin C
chr6_+_39836474 0.93 ENSDART00000112637
smarcc2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
chr14_-_5678457 0.92 ENSDART00000012116
tlx2
T cell leukemia homeobox 2
chr9_-_1970071 0.90 ENSDART00000080608
hoxd10a
homeobox D10a
chr16_+_23811554 0.87 ENSDART00000114336
si:dkey-7f3.9
si:dkey-7f3.9
chr20_+_4392687 0.87 ENSDART00000187271
im:7142702
im:7142702
chr10_-_17284055 0.86 ENSDART00000167464
GNAZ
G protein subunit alpha z
chr15_+_19682013 0.86 ENSDART00000127368
si:dkey-4p15.5
si:dkey-4p15.5
chr13_-_21688176 0.85 ENSDART00000063825
sprn
shadow of prion protein
chr25_-_225964 0.80 ENSDART00000193424
CABZ01113818.1

chr7_-_15370042 0.74 ENSDART00000128183
ANPEP
si:ch211-276a23.5
chr23_-_19953089 0.73 ENSDART00000153828
atp2b3b
ATPase plasma membrane Ca2+ transporting 3b
chr17_+_18117358 0.72 ENSDART00000144894
bcl11ba
B cell CLL/lymphoma 11Ba
chr25_-_210730 0.72 ENSDART00000187580
FP236318.1

chr17_+_18117029 0.71 ENSDART00000154646
ENSDART00000179739
bcl11ba
B cell CLL/lymphoma 11Ba
chr20_-_53435483 0.69 ENSDART00000135091
mettl24
methyltransferase like 24
chr23_+_23119008 0.69 ENSDART00000132418
samd11
sterile alpha motif domain containing 11
chr6_+_41099787 0.68 ENSDART00000186884
fkbp5
FK506 binding protein 5
chr21_+_43669943 0.65 ENSDART00000136025
tmlhe
trimethyllysine hydroxylase, epsilon
chr10_+_37927100 0.63 ENSDART00000172548
bhlha9
basic helix-loop-helix family, member a9
chr19_+_30662529 0.62 ENSDART00000175662
fam49al
family with sequence similarity 49, member A-like
chr13_+_23157053 0.61 ENSDART00000162359
sorbs1
sorbin and SH3 domain containing 1
chr21_-_43040780 0.61 ENSDART00000187037
jakmip2
janus kinase and microtubule interacting protein 2
chr25_+_33939728 0.59 ENSDART00000148537
roraa
RAR-related orphan receptor A, paralog a
chr6_+_40671336 0.59 ENSDART00000111639
ENSDART00000186617
rereb
arginine-glutamic acid dipeptide (RE) repeats b
chr3_+_39540014 0.55 ENSDART00000074848
zgc:165423
zgc:165423
chr7_-_31618166 0.55 ENSDART00000111388
igdcc3
immunoglobulin superfamily, DCC subclass, member 3
chr7_-_20453661 0.55 ENSDART00000174001
ntn5
netrin 5
chr6_+_48618512 0.55 ENSDART00000111190
FAM19A3
si:dkey-238f9.1
chr25_+_14092871 0.55 ENSDART00000067239
guca1g
guanylate cyclase activator 1g
chr4_+_7827261 0.52 ENSDART00000129568
phyh
phytanoyl-CoA 2-hydroxylase
chr15_+_19681718 0.51 ENSDART00000164803
si:dkey-4p15.5
si:dkey-4p15.5
chr18_+_8340886 0.50 ENSDART00000081132
cpt1b
carnitine palmitoyltransferase 1B (muscle)
chr17_-_37054959 0.47 ENSDART00000151921
dnmt3ab
DNA (cytosine-5-)-methyltransferase 3 alpha b
chr10_-_22057001 0.47 ENSDART00000016575
tlx3b
T cell leukemia homeobox 3b
chr6_+_39506043 0.45 ENSDART00000086260
CR388364.1

chr8_-_14091886 0.43 ENSDART00000137857
si:ch211-229n2.7
si:ch211-229n2.7
chr3_+_19299309 0.41 ENSDART00000046297
ENSDART00000146955
ldlra
low density lipoprotein receptor a
chr13_-_22843562 0.41 ENSDART00000142738
pbld
phenazine biosynthesis like protein domain containing
chr8_-_23578660 0.40 ENSDART00000039080
wasb
Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b
chr10_+_35439952 0.39 ENSDART00000006284
hhla2a.2
HERV-H LTR-associating 2a, tandem duplicate 2
chr23_-_10175898 0.39 ENSDART00000146185
krt5
keratin 5
chr5_-_50992690 0.36 ENSDART00000149553
ENSDART00000097460
ENSDART00000192021
hmgcra
3-hydroxy-3-methylglutaryl-CoA reductase a
chr6_-_30932078 0.33 ENSDART00000028612
pde4ba
phosphodiesterase 4B, cAMP-specific a
chr5_+_20693724 0.31 ENSDART00000141368
si:ch211-240b21.2
si:ch211-240b21.2
chr5_+_1079423 0.31 ENSDART00000172231
si:zfos-128g4.2
si:zfos-128g4.2
chr25_+_10830269 0.30 ENSDART00000175736
si:ch211-147g22.5
si:ch211-147g22.5
chr1_-_46632948 0.30 ENSDART00000148893
ENSDART00000053232
cdadc1
cytidine and dCMP deaminase domain containing 1
chr19_+_20724347 0.29 ENSDART00000090757
kat2b
K(lysine) acetyltransferase 2B
chr21_-_5879897 0.27 ENSDART00000184034
rpl35
ribosomal protein L35
chr6_+_2030703 0.27 ENSDART00000109679
ENSDART00000187502
ENSDART00000191165
ENSDART00000187544
quo
quattro
chr25_+_7492663 0.26 ENSDART00000166496
cat
catalase
chr15_+_46386261 0.26 ENSDART00000191793
igsf11
immunoglobulin superfamily member 11
chr4_+_57192681 0.26 ENSDART00000190438
si:dkey-16p6.4
si:dkey-16p6.4
chr12_+_387850 0.25 ENSDART00000182326
gsg1l2b
gsg1-like 2b
chr11_+_45287541 0.23 ENSDART00000165321
ENSDART00000173116
pycr1b
pyrroline-5-carboxylate reductase 1b
chr10_+_29260096 0.23 ENSDART00000088973
sytl2a
synaptotagmin-like 2a
chr23_-_19230627 0.23 ENSDART00000007122
guca1b
guanylate cyclase activator 1B
chr4_-_43616331 0.23 ENSDART00000183211
ENSDART00000150240
si:dkey-16p6.4
si:dkey-16p6.4
chr2_+_38924975 0.19 ENSDART00000109219
rem2
RAS (RAD and GEM)-like GTP binding 2
chr15_+_16886196 0.19 ENSDART00000139296
ENSDART00000049196
gdpd1
glycerophosphodiester phosphodiesterase domain containing 1
chr11_-_17964525 0.19 ENSDART00000018948
cishb
cytokine inducible SH2-containing protein b
chr8_+_22472584 0.17 ENSDART00000138303
si:dkey-23c22.9
si:dkey-23c22.9
chr7_+_35268054 0.16 ENSDART00000113842
dpep2
dipeptidase 2
chr20_+_13175379 0.16 ENSDART00000025644
ppp2r5a
protein phosphatase 2, regulatory subunit B', alpha isoform
chr16_+_52751445 0.14 ENSDART00000191807
atp6v1c1a
ATPase H+ transporting V1 subunit C1a
chr4_+_69712223 0.14 ENSDART00000163035
ENSDART00000164475
si:dkey-238o14.1
zgc:174944
si:dkey-238o14.1
zgc:174944
chr12_-_17024079 0.13 ENSDART00000129027
ifit11
interferon-induced protein with tetratricopeptide repeats 11
chr8_+_18044257 0.13 ENSDART00000029255
glis1b
GLIS family zinc finger 1b
chr9_+_32301456 0.13 ENSDART00000078608
ENSDART00000185153
ENSDART00000144947
hspe1
heat shock 10 protein 1
chr7_-_1918971 0.12 ENSDART00000181759
CABZ01040626.1

chr9_+_24095677 0.11 ENSDART00000150443
lrrfip1a
leucine rich repeat (in FLII) interacting protein 1a
chr25_-_21609645 0.11 ENSDART00000087817
DOCK4 (1 of many)
si:dkey-81e3.1
chr8_+_22405477 0.10 ENSDART00000148267
si:dkey-23c22.7
si:dkey-23c22.7
chr4_-_63166758 0.10 ENSDART00000192765
CR450780.1

chr3_-_40976288 0.08 ENSDART00000193553
cyp3c1
cytochrome P450, family 3, subfamily c, polypeptide 1
chr15_+_44133972 0.08 ENSDART00000157846
ENSDART00000191082
CU655961.2

chr7_-_30639385 0.08 ENSDART00000173618
myo1ea
myosin IE, a
chr17_+_33311784 0.07 ENSDART00000156229
si:ch211-132f19.7
si:ch211-132f19.7
chr22_-_17781213 0.07 ENSDART00000137984
si:ch73-63e15.2
si:ch73-63e15.2
chr21_+_11401247 0.06 ENSDART00000143952
cel.1
carboxyl ester lipase, tandem duplicate 1
chr9_+_42270043 0.06 ENSDART00000137435
si:dkey-10c21.1
si:dkey-10c21.1
chr4_-_70263609 0.05 ENSDART00000163868
si:dkey-3h2.3
si:dkey-3h2.3
chr4_-_47096170 0.05 ENSDART00000161079
si:dkey-26m3.3
si:dkey-26m3.3
chr22_+_10215558 0.04 ENSDART00000063274
kctd6a
potassium channel tetramerization domain containing 6a
chr4_-_63559311 0.04 ENSDART00000164415
si:dkey-16p6.1
si:dkey-16p6.1
chr11_-_5563498 0.03 ENSDART00000160835
pex11g
peroxisomal biogenesis factor 11 gamma
chr4_+_58668661 0.03 ENSDART00000188815
CR388148.2

chr4_+_76973771 0.02 ENSDART00000142978
si:dkey-240n22.3
si:dkey-240n22.3
chr2_+_52232630 0.02 ENSDART00000006216
plpp2a
phospholipid phosphatase 2a
chr4_-_71267461 0.02 ENSDART00000161219
ENSDART00000151838
si:dkeyp-51g9.4
si:dkeyp-51g9.4
chr3_-_39627412 0.01 ENSDART00000123292
si:dkey-27o4.1
si:dkey-27o4.1
chr4_-_34775762 0.01 ENSDART00000167262
si:dkey-146m20.14
si:dkey-146m20.14
chr4_-_47095583 0.01 ENSDART00000183595
ENSDART00000183279
ENSDART00000191638
si:dkey-26m3.3
si:dkey-26m3.3
chr1_-_55118745 0.01 ENSDART00000133915
sertad2a
SERTA domain containing 2a
chr23_+_17102960 0.00 ENSDART00000053414
commd7
COMM domain containing 7
chr12_+_46605600 0.00 ENSDART00000123533
FADS6
fatty acid desaturase 6
chr1_-_49947290 0.00 ENSDART00000141476
sgms2
sphingomyelin synthase 2

Network of associatons between targets according to the STRING database.

First level regulatory network of nr6a1b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582) axon regeneration at neuromuscular junction(GO:0014814) positive regulation of synaptic growth at neuromuscular junction(GO:0045887)
0.2 0.2 GO:0070291 N-acylethanolamine metabolic process(GO:0070291)
0.1 1.2 GO:0006558 L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.1 0.3 GO:0090069 regulation of ribosome biogenesis(GO:0090069)
0.1 0.7 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 0.4 GO:0070292 N-acylphosphatidylethanolamine metabolic process(GO:0070292)
0.1 0.5 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.1 0.4 GO:0032367 intracellular cholesterol transport(GO:0032367)
0.0 1.5 GO:0007568 aging(GO:0007568)
0.0 0.5 GO:0009437 carnitine metabolic process(GO:0009437)
0.0 1.1 GO:0097194 execution phase of apoptosis(GO:0097194)
0.0 0.3 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0 0.4 GO:0051127 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.7 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.3 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.3 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0 0.9 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.0 1.7 GO:0031101 fin regeneration(GO:0031101)
0.0 1.2 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.5 GO:0006306 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 0.3 GO:0042542 response to hydrogen peroxide(GO:0042542) response to copper ion(GO:0046688)
0.0 0.3 GO:0097324 melanocyte migration(GO:0097324)
0.0 0.4 GO:0021587 cerebellum morphogenesis(GO:0021587)
0.0 0.3 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.4 GO:0006695 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0071564 npBAF complex(GO:0071564)
0.0 0.4 GO:0045095 keratin filament(GO:0045095)
0.0 1.2 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 0.1 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.0 1.0 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 0.4 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.1 1.2 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.1 0.4 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.1 0.8 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.1 1.2 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.1 0.5 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 1.1 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1 1.2 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.2 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0 0.3 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.5 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.3 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.0 0.2 GO:0070573 metallodipeptidase activity(GO:0070573)
0.0 0.3 GO:0004096 catalase activity(GO:0004096)
0.0 0.7 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:0004771 sterol esterase activity(GO:0004771)
0.0 1.2 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.0 0.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.2 GO:0042043 neurexin family protein binding(GO:0042043)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 PID ALK2 PATHWAY ALK2 signaling events
0.1 1.0 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 1.1 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.5 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 1.8 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.3 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.2 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.6 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 0.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.7 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.5 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.3 PID FOXO PATHWAY FoxO family signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 0.3 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.5 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.6 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.3 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.5 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.5 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 1.2 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.2 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 1.0 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions