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PRJNA195909:zebrafish embryo and larva development

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Results for roraa+rorab

Z-value: 0.92

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Transcription factors associated with roraa+rorab

Gene Symbol Gene ID Gene Info
ENSDARG00000001910 RAR-related orphan receptor A, paralog b
ENSDARG00000031768 RAR-related orphan receptor A, paralog a
ENSDARG00000109324 RAR-related orphan receptor A, paralog b
ENSDARG00000113275 RAR-related orphan receptor A, paralog b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
rorabdr11_v1_chr7_-_29571615_295716150.732.5e-02Click!
roraadr11_v1_chr25_+_33939728_339397280.472.0e-01Click!

Activity profile of roraa+rorab motif

Sorted Z-values of roraa+rorab motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_29900546 1.63 ENSDART00000147441
lens intrinsic membrane protein 2.1
chr11_+_30729745 1.55 ENSDART00000103270
solute carrier family 22 (organic anion transporter), member 7a
chr23_+_44741500 1.30 ENSDART00000166421
ATPase Na+/K+ transporting subunit beta 2a
chr21_+_7582036 1.28 ENSDART00000135485
ENSDART00000027268
orthopedia homeobox a
chr21_+_20771082 1.15 ENSDART00000079732
3-oxoacid CoA transferase 1b
chr1_+_12763920 1.12 ENSDART00000189465
protocadherin 10a
chr19_-_5332784 1.12 ENSDART00000010373
keratin, type 1, gene 19d
chr23_-_24488696 1.10 ENSDART00000155593
transmembrane protein 82
chr20_+_16750177 1.09 ENSDART00000185357
calmodulin 1b
chr6_+_3710865 1.04 ENSDART00000170781
phosphatase, orphan 2
chr6_-_39764995 0.99 ENSDART00000085277
phosphofructokinase, muscle b
chr13_-_31452516 0.99 ENSDART00000193268
reticulon 1a
chr4_+_7677318 0.97 ENSDART00000149218
ELK3, ETS-domain protein
chr9_-_1970071 0.92 ENSDART00000080608
homeobox D10a
chr25_-_31396479 0.89 ENSDART00000156828
proline rich 33
chr1_-_50859053 0.89 ENSDART00000132779
ENSDART00000137648
si:dkeyp-123h10.2
chr7_+_40228422 0.88 ENSDART00000052222
protein tyrosine phosphatase, receptor type, N polypeptide 2
chr5_-_41831646 0.88 ENSDART00000134326
si:dkey-65b12.6
chr5_-_68916455 0.87 ENSDART00000171465
ankyrin 1, erythrocytic a
chr3_-_26109322 0.86 ENSDART00000113780
zgc:162612
chr16_-_28856112 0.86 ENSDART00000078543
synaptotagmin XIb
chr15_+_19797918 0.85 ENSDART00000113314
si:ch211-229d2.5
chr10_+_37927100 0.84 ENSDART00000172548
basic helix-loop-helix family, member a9
chr7_+_29133321 0.81 ENSDART00000052346
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b
chr5_+_20693724 0.81 ENSDART00000141368
si:ch211-240b21.2
chr19_+_40856534 0.80 ENSDART00000051950
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr4_-_1360495 0.77 ENSDART00000164623
pleiotrophin
chr8_+_25902170 0.76 ENSDART00000193130
ras homolog gene family, member Ab
chr19_+_30662529 0.76 ENSDART00000175662
family with sequence similarity 49, member A-like
chr4_+_18963822 0.74 ENSDART00000066975
ENSDART00000066973
IMP (inosine 5'-monophosphate) dehydrogenase 1b
chr3_+_1182315 0.72 ENSDART00000055430
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6
chr6_-_39765546 0.70 ENSDART00000185767
phosphofructokinase, muscle b
chr7_+_40884012 0.70 ENSDART00000149395
sonic hedgehog a
chr7_-_4036184 0.67 ENSDART00000019949
NDRG family member 2
chr18_+_8340886 0.67 ENSDART00000081132
carnitine palmitoyltransferase 1B (muscle)
chr10_+_20128267 0.67 ENSDART00000064615
dematin actin binding protein
chr5_+_1219187 0.67 ENSDART00000129490
expressed sequence BC139872
chr10_-_29101715 0.66 ENSDART00000149674
ENSDART00000171194
ENSDART00000192019
si:ch211-103f14.3
chr4_-_17629444 0.66 ENSDART00000108814
nuclear receptor interacting protein 2
chr7_+_48805534 0.65 ENSDART00000145375
ENSDART00000148744
carnitine palmitoyltransferase 1Aa (liver)
chr15_-_12270857 0.65 ENSDART00000170093
si:dkey-36i7.3
chr6_-_10835849 0.64 ENSDART00000005903
ENSDART00000135065
ATP synthase membrane subunit c locus 3b
chr10_+_17850934 0.63 ENSDART00000113666
ENSDART00000145936
PHD finger protein 24
chr20_+_40150612 0.61 ENSDART00000143680
ENSDART00000109681
ENSDART00000101041
ENSDART00000121818
triadin
chr7_-_24046999 0.61 ENSDART00000144616
ENSDART00000124653
ENSDART00000127813
dehydrogenase/reductase (SDR family) member 4
chr19_+_40856807 0.59 ENSDART00000139083
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr14_+_33882973 0.58 ENSDART00000019396
chloride intracellular channel 2
chr23_-_15284757 0.57 ENSDART00000139135
sulfatase 2b
chr10_-_17103651 0.57 ENSDART00000108959
ring finger protein 208
chr14_-_33454595 0.56 ENSDART00000109615
ENSDART00000173267
ENSDART00000185737
ENSDART00000190989
transmembrane protein 255A
chr23_-_5683147 0.56 ENSDART00000102766
ENSDART00000067351
troponin T type 2a (cardiac)
chr15_-_21239416 0.54 ENSDART00000155787
si:dkey-105h12.2
chr16_+_21242491 0.54 ENSDART00000145886
oxysterol binding protein-like 3b
chr1_+_23783349 0.53 ENSDART00000007531
slit homolog 2 (Drosophila)
chr5_-_55395964 0.53 ENSDART00000145791
prune homolog 2 (Drosophila)
chr18_-_48492951 0.53 ENSDART00000146346
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 6
chr19_-_32487469 0.52 ENSDART00000050130
guanosine monophosphate reductase
chr16_+_5678071 0.51 ENSDART00000011166
ENSDART00000134198
ENSDART00000131575
zgc:158689
chr21_+_5882300 0.51 ENSDART00000165065
ubiquinol-cytochrome c reductase, complex III subunit X
chr11_+_5842632 0.51 ENSDART00000111374
ENSDART00000158599
NADH dehydrogenase (ubiquinone) Fe-S protein 7, (NADH-coenzyme Q reductase)
chr4_+_2620751 0.50 ENSDART00000013924
G protein-coupled receptor 22a
chr7_-_33351485 0.49 ENSDART00000146420
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr10_-_11385155 0.48 ENSDART00000064214
placenta-specific 8, tandem duplicate 1
chr5_-_41838354 0.47 ENSDART00000146793
si:dkey-65b12.6
chr8_+_43016714 0.47 ENSDART00000142671
Ras association (RalGDS/AF-6) domain family member 2a
chr17_+_25290136 0.46 ENSDART00000173295
kelch repeat and BTB (POZ) domain containing 11
chr6_-_40312091 0.45 ENSDART00000154878
collagen, type VII, alpha 1
chr6_-_11523987 0.45 ENSDART00000189363
GULP, engulfment adaptor PTB domain containing 1b
chr10_+_20113830 0.45 ENSDART00000139722
dematin actin binding protein
chr9_+_41914378 0.45 ENSDART00000130434
ENSDART00000007058
collagen type XVIII alpha 1 chain a
chr6_-_28980756 0.45 ENSDART00000014661
glomulin, FKBP associated protein b
chr9_-_21067971 0.45 ENSDART00000004333
T-box 15
chr11_+_24900123 0.43 ENSDART00000044987
ENSDART00000148023
translocase of inner mitochondrial membrane 17 homolog A (yeast)
chr16_+_12236339 0.43 ENSDART00000132468
triosephosphate isomerase 1b
chr12_-_45876387 0.42 ENSDART00000043210
ENSDART00000149044
paired box 2b
chr7_+_48805725 0.41 ENSDART00000166543
carnitine palmitoyltransferase 1Aa (liver)
chr10_-_7988396 0.41 ENSDART00000141445
ENSDART00000024282
EWS RNA-binding protein 1a
chr7_+_20475788 0.41 ENSDART00000171155
si:dkey-19b23.13
chr14_+_9583588 0.41 ENSDART00000164101
transmembrane protein 129, E3 ubiquitin protein ligase
chr2_-_56655769 0.41 ENSDART00000113589
glutathione peroxidase 4b
chr1_-_45177373 0.40 ENSDART00000143142
ENSDART00000034549
zgc:111983
chr18_-_1185772 0.40 ENSDART00000143245
neuroplastin b
chr22_-_24285432 0.39 ENSDART00000164083
si:ch211-117l17.4
chr20_-_25709247 0.39 ENSDART00000146711
si:dkeyp-117h8.2
chr8_+_22478090 0.39 ENSDART00000170263
si:ch211-261n11.7
chr3_+_32698424 0.39 ENSDART00000055340
FUS RNA binding protein
chr16_-_50229193 0.39 ENSDART00000161782
ENSDART00000010081
electron-transfer-flavoprotein, beta polypeptide
chr23_+_42813415 0.38 ENSDART00000055577
myosin, light chain 9a, regulatory
chr19_+_37620342 0.37 ENSDART00000158960
thrombospondin, type I, domain containing 7Aa
chr13_+_50375800 0.37 ENSDART00000099537
cytochrome c oxidase subunit Vb 2
chr25_+_3326885 0.37 ENSDART00000104866
lactate dehydrogenase Bb
chr25_+_3327071 0.37 ENSDART00000136131
ENSDART00000133243
lactate dehydrogenase Bb
chr10_-_32524771 0.37 ENSDART00000066793
diacylglycerol O-acyltransferase 2
chr22_-_11124419 0.37 ENSDART00000149634
ATPase H+ transporting accessory protein 2
chr2_+_30787128 0.36 ENSDART00000189233
ATPase H+ transporting V1 subunit H
chr17_+_33340675 0.36 ENSDART00000184396
ENSDART00000077553
xanthine dehydrogenase
chr18_-_48517040 0.36 ENSDART00000143645
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 3
chr8_+_22477922 0.35 ENSDART00000189766
ENSDART00000179717
si:ch211-261n11.7
chr1_+_34496855 0.34 ENSDART00000012873
Kruppel-like factor 12a
chr23_-_19953089 0.33 ENSDART00000153828
ATPase plasma membrane Ca2+ transporting 3b
chr6_-_1514767 0.32 ENSDART00000067586
coiled-coil-helix-coiled-coil-helix domain containing 6b
chr10_+_1638876 0.31 ENSDART00000184484
ENSDART00000060946
ENSDART00000181251
small G protein signaling modulator 1b
chr22_+_21252790 0.31 ENSDART00000079046
C3 and PZP-like, alpha-2-macroglobulin domain containing 8
chr14_-_29858883 0.31 ENSDART00000141034
sorbin and SH3 domain containing 2b
chr2_-_4797512 0.31 ENSDART00000160765
tyrosine kinase, non-receptor, 2b
chr9_-_1986014 0.31 ENSDART00000142842
homeobox D12a
chr3_+_12484008 0.31 ENSDART00000182229
vasorin b
chr15_-_14486534 0.30 ENSDART00000179368
numb homolog (Drosophila)-like
chr4_-_25181552 0.30 ENSDART00000066930
ATP synthase F1 subunit gamma
chr19_+_19976990 0.30 ENSDART00000052627
neuropeptide VF precursor
chr22_-_17574511 0.29 ENSDART00000181496
phosphatidylinositol-4-phosphate 5-kinase, type I, gamma a
chr6_+_8339298 0.28 ENSDART00000151672
si:ch211-276a17.5
chr5_-_41841892 0.27 ENSDART00000167089
si:dkey-65b12.6
chr3_+_58167288 0.27 ENSDART00000155874
ENSDART00000010395
ubiquinol-cytochrome c reductase core protein 2a
chr7_-_29341233 0.26 ENSDART00000140938
ENSDART00000147251
transient receptor potential cation channel, subfamily M, member 1a
chr11_+_28476298 0.26 ENSDART00000122319
leucine rich repeat containing 38b
chr8_+_26125218 0.26 ENSDART00000145095
cadherin, EGF LAG seven-pass G-type receptor 3
chr8_+_14158021 0.26 ENSDART00000080832
si:dkey-6n6.2
chr10_-_26273629 0.25 ENSDART00000147790
dachsous cadherin-related 1b
chr14_+_23518110 0.25 ENSDART00000112930
si:ch211-221f10.2
chr13_-_18195942 0.24 ENSDART00000079902
solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16
chr5_-_29780752 0.24 ENSDART00000137400
ENSDART00000145021
cilia and flagella associated protein 77
chr14_+_48045193 0.23 ENSDART00000124773
peptidylprolyl isomerase D
chr12_-_25201576 0.23 ENSDART00000077188
cytochrome c oxidase subunit VIIa polypeptide 3
chr7_+_44484853 0.23 ENSDART00000189079
ENSDART00000121826
brain expressed, associated with NEDD4, 1
chr15_+_45575180 0.23 ENSDART00000180441
claudin 15-like b
chr10_+_4924388 0.22 ENSDART00000108595
solute carrier family 46 member 2
chr6_+_51773873 0.22 ENSDART00000156516
transmembrane protein 74B
chr20_+_5564042 0.22 ENSDART00000090934
ENSDART00000127050
neurexin 3b
chr1_-_44704261 0.22 ENSDART00000133210
si:dkey-28b4.8
chr18_+_14529005 0.22 ENSDART00000186379
potassium voltage-gated channel, subfamily G, member 4a
chr12_-_47648538 0.22 ENSDART00000108477
fumarate hydratase
chr7_-_24005268 0.21 ENSDART00000173608
si:dkey-183c6.9
chr3_-_19091024 0.21 ENSDART00000188485
ENSDART00000110554
glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca
chr7_-_30227878 0.21 ENSDART00000173514
zinc finger protein 710b
chr17_-_53353653 0.21 ENSDART00000180744
ENSDART00000026879
un-named sa911
chr12_-_45875946 0.21 ENSDART00000149970
paired box 2b
chr2_+_58841181 0.21 ENSDART00000164102
cold inducible RNA binding protein a
chr21_+_15709061 0.20 ENSDART00000065772
D-dopachrome tautomerase
chr8_+_51084993 0.20 ENSDART00000127709
ENSDART00000053768
si:dkey-32e23.6
chr5_+_5689476 0.18 ENSDART00000022729
un-named sa808
chr18_+_36631923 0.18 ENSDART00000098980
zinc finger protein 296
chr15_+_29362714 0.18 ENSDART00000099916
ENSDART00000126196
guanylate cyclase 2F, retinal
chr6_-_49873020 0.17 ENSDART00000148511
GNAS complex locus
chr12_+_7399403 0.17 ENSDART00000103526
BicC family RNA binding protein 1b
chr1_+_54115839 0.17 ENSDART00000180214

chr25_-_1235457 0.17 ENSDART00000093093
coronin, actin binding protein, 2Bb
chr6_-_10320676 0.17 ENSDART00000151247
sodium channel, voltage-gated, type I like, alpha b
chr19_+_10331325 0.17 ENSDART00000143930
transmembrane protein 238a
chr10_+_19528321 0.16 ENSDART00000184816
V-set and immunoglobulin domain containing 8a
chr17_-_26610814 0.16 ENSDART00000133402
ENSDART00000016608
mitochondrial ribosomal protein L57
chr11_-_37995501 0.16 ENSDART00000192096
solute carrier family 41 (magnesium transporter), member 1
chr7_-_8156169 0.15 ENSDART00000182960
ENSDART00000190184
ENSDART00000190885
ENSDART00000189867
ENSDART00000160836
si:cabz01030277.1
si:ch211-163c2.3
chr1_+_31573225 0.15 ENSDART00000075286
solute carrier family 2 (facilitated glucose transporter), member 15b
chr7_-_8014186 0.15 ENSDART00000190012
si:cabz01030277.1
chr6_-_49170390 0.15 ENSDART00000182255
nerve growth factor b (beta polypeptide)
chr19_+_20724347 0.15 ENSDART00000090757
K(lysine) acetyltransferase 2B
chr1_+_44826593 0.15 ENSDART00000162200
zgc:165520
chr1_+_31725154 0.14 ENSDART00000112333
ENSDART00000189801
cyclin and CBS domain divalent metal cation transport mediator 2b
chr14_-_30490465 0.14 ENSDART00000173107
mitochondrial calcium uptake family, member 3b
chr24_-_21913426 0.14 ENSDART00000081178
C1q and TNF related 9
chr2_-_16380283 0.13 ENSDART00000149992
si:dkey-231j24.3
chr25_+_31264155 0.13 ENSDART00000012256
troponin I type 2a (skeletal, fast), tandem duplicate 3
chr14_-_29859067 0.13 ENSDART00000136380
sorbin and SH3 domain containing 2b
chr6_-_9922266 0.13 ENSDART00000151549
Pim proto-oncogene, serine/threonine kinase, related 73
chr8_+_18463797 0.12 ENSDART00000148958
ALK and LTK ligand 1
chr4_+_9536860 0.11 ENSDART00000130083
LSM8 homolog, U6 small nuclear RNA associated
chr19_+_2590182 0.11 ENSDART00000162293
si:ch73-345f18.3
chr9_-_16877456 0.11 ENSDART00000161105
ENSDART00000160869
F-box and leucine-rich repeat protein 3a
chr13_-_29406534 0.11 ENSDART00000100877
zgc:153142
chr22_+_29135846 0.11 ENSDART00000143811
BAI1-associated protein 2-like 2b
chr23_+_19564392 0.11 ENSDART00000144746
ATPase H+ transporting accessory protein 1 like b
chr8_+_14792830 0.11 ENSDART00000139972
calcium channel, voltage-dependent, R type, alpha 1E subunit a
chr6_-_49159207 0.11 ENSDART00000041942
tetraspanin 2a
chr7_-_26446726 0.11 ENSDART00000173607
zgc:172079
chr9_-_53666031 0.10 ENSDART00000126314
protocadherin 8
chr1_+_19515228 0.10 ENSDART00000103091
clarin 2
chr21_-_22724980 0.10 ENSDART00000035469
complement component 1, q subcomponent, A chain
chr15_+_1705167 0.10 ENSDART00000081940
otolin 1b
chr12_-_44199316 0.10 ENSDART00000170378
si:ch73-329n5.1
chr8_+_30664077 0.10 ENSDART00000138750
adenosine A2a receptor a
chr17_-_36818176 0.09 ENSDART00000061762
myosin VIb
chr17_+_15534815 0.09 ENSDART00000159426
myristoylated alanine-rich protein kinase C substrate b
chr16_+_26738404 0.09 ENSDART00000163110
fibrinogen silencer binding protein
chr8_+_18464235 0.08 ENSDART00000110571
ALK and LTK ligand 1
chr18_+_7594012 0.08 ENSDART00000062150
zgc:77752
chr20_+_43623064 0.08 ENSDART00000186659
si:dkey-206f10.1
chr16_-_16619854 0.08 ENSDART00000150512
ENSDART00000191306
ENSDART00000181773
ENSDART00000183231
cytochrome P450, family 21, subfamily A, polypeptide 2
chr11_-_29650930 0.08 ENSDART00000166969
chromodomain helicase DNA binding protein 5
chr16_+_27349585 0.07 ENSDART00000142573
nuclear receptor subfamily 4, group A, member 3
chr19_-_3574060 0.07 ENSDART00000105120
transmembrane protein 170B
chr24_+_29449690 0.07 ENSDART00000105743
ENSDART00000193556
ENSDART00000145816
netrin g1a
chr2_-_44971551 0.07 ENSDART00000018818
mitochondrial E3 ubiquitin protein ligase 1a
chr15_+_31820536 0.07 ENSDART00000045921
furry homolog a (Drosophila)
chr3_+_13637383 0.06 ENSDART00000166000
si:ch211-194b1.1
chr11_+_25278772 0.06 ENSDART00000188630
cylindromatosis (turban tumor syndrome), b
chr21_-_20840714 0.06 ENSDART00000144861
ENSDART00000139430
complement component 6
chr18_-_29962234 0.06 ENSDART00000144996
si:ch73-103b9.2
chr6_-_15603675 0.06 ENSDART00000143502
leucine rich repeat (in FLII) interacting protein 1b
chr7_+_67494107 0.06 ENSDART00000185653
copine VII

Network of associatons between targets according to the STRING database.

First level regulatory network of roraa+rorab

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0046952 ketone body catabolic process(GO:0046952)
0.2 1.3 GO:0051703 mammillary body development(GO:0021767) social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
0.2 0.5 GO:0007414 axonal defasciculation(GO:0007414)
0.2 0.7 GO:0048618 post-embryonic foregut morphogenesis(GO:0048618)
0.2 1.7 GO:0061615 glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.1 0.6 GO:0003228 atrial cardiac muscle tissue development(GO:0003228)
0.1 0.5 GO:0015990 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) electron transport coupled proton transport(GO:0015990)
0.1 0.4 GO:0006145 purine nucleobase catabolic process(GO:0006145)
0.1 0.8 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.1 1.1 GO:0031998 regulation of fatty acid beta-oxidation(GO:0031998)
0.1 0.4 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.1 0.4 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.1 0.3 GO:1902410 mitotic cytokinetic process(GO:1902410) mitotic cleavage furrow formation(GO:1903673)
0.1 0.7 GO:0006177 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.1 0.3 GO:0044060 regulation of endocrine process(GO:0044060) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) endocrine hormone secretion(GO:0060986)
0.1 0.6 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 1.3 GO:0036376 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.1 1.1 GO:0097324 melanocyte migration(GO:0097324)
0.1 0.2 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.1 0.4 GO:0061075 eye pigmentation(GO:0048069) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868)
0.1 0.5 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 0.1 GO:0090069 regulation of ribosome biogenesis(GO:0090069)
0.0 0.5 GO:0006798 polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.0 0.7 GO:0009437 carnitine metabolic process(GO:0009437)
0.0 1.1 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.2 GO:2000171 negative regulation of dendrite development(GO:2000171)
0.0 0.2 GO:0070376 ERK5 cascade(GO:0070375) regulation of ERK5 cascade(GO:0070376) positive regulation of ERK5 cascade(GO:0070378)
0.0 0.6 GO:0014846 esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0 0.9 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.2 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 0.1 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.0 0.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.5 GO:0006144 purine nucleobase metabolic process(GO:0006144)
0.0 0.9 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.5 GO:1901222 regulation of NIK/NF-kappaB signaling(GO:1901222)
0.0 0.3 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.0 0.3 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.4 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.6 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.0 0.8 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 0.2 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.1 GO:0046166 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.0 0.5 GO:0071907 determination of digestive tract left/right asymmetry(GO:0071907)
0.0 0.1 GO:0038065 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.0 0.4 GO:0070593 dendrite self-avoidance(GO:0070593)
0.0 0.4 GO:0007007 inner mitochondrial membrane organization(GO:0007007)
0.0 0.2 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.8 GO:0051781 positive regulation of cell division(GO:0051781)
0.0 0.3 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.0 0.2 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.0 0.1 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.2 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 0.4 GO:0072015 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0 0.6 GO:1990573 potassium ion import across plasma membrane(GO:1990573)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:1902560 GMP reductase complex(GO:1902560)
0.2 1.7 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.1 1.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.1 1.4 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.1 0.3 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.1 0.9 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 0.4 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.1 0.5 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.4 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 0.8 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 1.3 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.3 GO:0061617 MICOS complex(GO:0061617)
0.0 0.4 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 1.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.1 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.0 0.1 GO:0098645 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0 0.7 GO:0005861 troponin complex(GO:0005861)
0.0 0.6 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.1 GO:1990246 uniplex complex(GO:1990246)
0.0 0.1 GO:0005688 U6 snRNP(GO:0005688)
0.0 1.2 GO:0005741 mitochondrial outer membrane(GO:0005741)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.2 1.1 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
0.2 1.0 GO:0051430 mu-type opioid receptor binding(GO:0031852) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.2 0.5 GO:0016657 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.2 1.7 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.1 0.4 GO:0055105 ubiquitin-protein transferase inhibitor activity(GO:0055105)
0.1 0.7 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 0.7 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 0.4 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.1 0.7 GO:0005113 patched binding(GO:0005113)
0.1 0.4 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.1 1.4 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 1.3 GO:0001671 ATPase activator activity(GO:0001671)
0.1 0.9 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 0.3 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 0.6 GO:0031013 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.0 0.5 GO:0004309 exopolyphosphatase activity(GO:0004309)
0.0 0.2 GO:0030298 receptor signaling protein tyrosine kinase activator activity(GO:0030298)
0.0 0.4 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups(GO:0016725)
0.0 0.4 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.0 0.7 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.5 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.3 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.0 0.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.5 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.1 GO:0004807 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
0.0 0.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 1.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.1 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.0 0.9 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 2.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.2 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.4 GO:0036442 hydrogen-exporting ATPase activity(GO:0036442) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.5 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 1.0 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.4 GO:0009055 electron carrier activity(GO:0009055)
0.0 0.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.0 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.2 GO:0005163 nerve growth factor receptor binding(GO:0005163) neurotrophin receptor binding(GO:0005165)
0.0 0.2 GO:0004972 NMDA glutamate receptor activity(GO:0004972)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 0.8 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.5 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.7 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.5 NABA COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 0.4 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.1 0.5 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.7 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.5 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.4 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 1.6 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.2 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.1 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.2 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 0.4 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import