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PRJNA195909:zebrafish embryo and larva development

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Results for sox18

Z-value: 0.73

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Transcription factors associated with sox18

Gene Symbol Gene ID Gene Info
sox18
ENSDARG00000058598 SRY-box transcription factor 18

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
sox18dr11_v1_chr23_+_8797143_8797143-0.732.5e-02Click!

Activity profile of sox18 motif

Sorted Z-values of sox18 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_+_44994214 1.19 ENSDART00000141434
retsatl
retinol saturase (all-trans-retinol 13,14-reductase) like
chr8_+_23726708 1.10 ENSDART00000142395
mkrn4
makorin, ring finger protein, 4
chr17_+_24597001 1.07 ENSDART00000191834
rlf
rearranged L-myc fusion
chr7_+_24814866 0.96 ENSDART00000173581
si:ch211-226l4.6
si:ch211-226l4.6
chr7_-_24995631 0.84 ENSDART00000173955
ENSDART00000173791
rcor2
REST corepressor 2
chr22_+_25352530 0.83 ENSDART00000176742
ENSDART00000113186
si:dkey-240e12.6
si:dkey-240e12.6
chr5_-_5669879 0.76 ENSDART00000191963
CABZ01075628.1

chr1_+_45707219 0.72 ENSDART00000143363
si:ch211-214c7.4
si:ch211-214c7.4
chr14_+_30272891 0.66 ENSDART00000017122
asah1a
N-acylsphingosine amidohydrolase (acid ceramidase) 1a
chr4_-_8030583 0.63 ENSDART00000113628
si:ch211-240l19.8
si:ch211-240l19.8
chr6_+_49052741 0.57 ENSDART00000011876
sycp1
synaptonemal complex protein 1
chr19_+_15440841 0.57 ENSDART00000182329
lin28a
lin-28 homolog A (C. elegans)
chr22_+_24559947 0.56 ENSDART00000169847
wdr47b
WD repeat domain 47b
chr5_+_3892551 0.55 ENSDART00000134396
rpain
RPA interacting protein
chr17_-_43594864 0.53 ENSDART00000139980
zfyve28
zinc finger, FYVE domain containing 28
chr21_+_21012210 0.53 ENSDART00000190317
ndr1
nodal-related 1
chr17_+_10570906 0.52 ENSDART00000182371
ENSDART00000176097
ENSDART00000110593
ENSDART00000169356
mgaa
MGA, MAX dimerization protein a
chr14_-_35400671 0.51 ENSDART00000129676
lsm11
LSM11, U7 small nuclear RNA associated
chr16_-_9449712 0.50 ENSDART00000136522
prpf3
PRP3 pre-mRNA processing factor 3 homolog (yeast)
chr1_+_49435017 0.49 ENSDART00000124833
pdcd11
programmed cell death 11
chr4_+_13412030 0.49 ENSDART00000003694
cand1
cullin-associated and neddylation-dissociated 1
chr19_+_9113932 0.46 ENSDART00000060442
setdb1a
SET domain, bifurcated 1a
chr21_-_5066462 0.46 ENSDART00000067733
zgc:77838
zgc:77838
chr23_-_10745288 0.46 ENSDART00000140745
ENSDART00000013768
eif4e3
eukaryotic translation initiation factor 4E family member 3
chr11_+_17984354 0.46 ENSDART00000179986
rpusd4
RNA pseudouridylate synthase domain containing 4
chr15_+_29727799 0.46 ENSDART00000182006
zgc:153372
zgc:153372
chr10_+_15511885 0.46 ENSDART00000165663
erbin
erbb2 interacting protein
chr7_+_22853788 0.46 ENSDART00000148502
clcn5b
chloride channel, voltage-sensitive 5b
chr17_-_14780578 0.46 ENSDART00000154690
si:ch211-266o15.1
si:ch211-266o15.1
chr8_-_25600888 0.46 ENSDART00000193860
stk38a
serine/threonine kinase 38a
chr2_-_9971609 0.44 ENSDART00000137924
ENSDART00000048655
ENSDART00000131613
zgc:55943
zgc:55943
chr5_-_16475374 0.44 ENSDART00000134274
ENSDART00000136004
piwil2
piwi-like RNA-mediated gene silencing 2
chr12_+_13348918 0.43 ENSDART00000181373
rnasen
ribonuclease type III, nuclear
chr3_+_22442445 0.42 ENSDART00000190921
wnk4b
WNK lysine deficient protein kinase 4b
chr11_+_17984167 0.41 ENSDART00000020283
ENSDART00000188329
rpusd4
RNA pseudouridylate synthase domain containing 4
chr14_-_24277805 0.40 ENSDART00000054243
dpf2l
D4, zinc and double PHD fingers family 2, like
chr7_+_69459759 0.40 ENSDART00000160500
ctdnep1b
CTD nuclear envelope phosphatase 1b
chr5_-_68259747 0.39 ENSDART00000188756
CABZ01083944.1

chr5_-_23517747 0.39 ENSDART00000137655
stag2a
stromal antigen 2a
chr16_-_21903083 0.37 ENSDART00000165849
setdb1b
SET domain, bifurcated 1b
chr10_-_42237304 0.37 ENSDART00000140341
tcf7l1a
transcription factor 7 like 1a
chr11_+_5565082 0.36 ENSDART00000112590
ENSDART00000183207
si:ch73-40i7.5
si:ch73-40i7.5
chr5_+_22459087 0.36 ENSDART00000134781
BX546499.1

chr3_+_34986837 0.34 ENSDART00000190341
smarce1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr16_+_29586468 0.34 ENSDART00000148926
mcl1b
MCL1, BCL2 family apoptosis regulator b
chr2_+_31942390 0.33 ENSDART00000138684
ENSDART00000146758
ENSDART00000137921
otulinb
OTU deubiquitinase with linear linkage specificity b
chr7_+_22688781 0.32 ENSDART00000173509
ugt5g1
UDP glucuronosyltransferase 5 family, polypeptide G1
chr3_-_31845816 0.31 ENSDART00000157028
map3k3
mitogen-activated protein kinase kinase kinase 3
chr7_+_73827805 0.31 ENSDART00000109316
zgc:173587
zgc:173587
chr3_+_34159192 0.30 ENSDART00000151119
carm1
coactivator-associated arginine methyltransferase 1
chr18_-_1270220 0.29 ENSDART00000193754
ugt5f1
UDP glucuronosyltransferase 5 family, polypeptide F1
chr25_-_35104083 0.29 ENSDART00000183252
ENSDART00000156727
si:dkey-108k21.21
si:dkey-108k21.21
chr9_+_44832032 0.28 ENSDART00000002633
frzb
frizzled related protein
chr24_-_24724233 0.27 ENSDART00000127044
ENSDART00000012399
armc1
armadillo repeat containing 1
chr22_+_1786230 0.27 ENSDART00000169318
ENSDART00000164948
znf1154
zinc finger protein 1154
chr13_-_45063686 0.26 ENSDART00000130467
ENSDART00000136679
chp1
calcineurin-like EF-hand protein 1
chr17_+_51682429 0.26 ENSDART00000004379
nol10
nucleolar protein 10
chr22_+_2533514 0.26 ENSDART00000147967
si:ch73-92e7.4
si:ch73-92e7.4
chr25_+_35061044 0.25 ENSDART00000111706
si:dkey-108k21.14
si:dkey-108k21.14
chr5_+_61863996 0.25 ENSDART00000082879
sympk
symplekin
chr13_+_25397098 0.24 ENSDART00000132953
gsto2
glutathione S-transferase omega 2
chr7_+_39011355 0.24 ENSDART00000173855
dgkza
diacylglycerol kinase, zeta a
chr2_+_33541928 0.23 ENSDART00000162852
BX548164.1

chr11_+_43751263 0.22 ENSDART00000163843
zgc:153431
zgc:153431
chr13_+_25396896 0.22 ENSDART00000041257
gsto2
glutathione S-transferase omega 2
chr19_+_43753995 0.22 ENSDART00000058504
SLC17A3
si:ch1073-513e17.1
chr11_+_29671661 0.22 ENSDART00000024318
ENSDART00000165024
rnf207a
ring finger protein 207a
chr13_-_31164749 0.22 ENSDART00000049180
mapk8a
mitogen-activated protein kinase 8a
chr1_-_32111882 0.22 ENSDART00000112639
ENSDART00000101958
pnpla4
patatin-like phospholipase domain containing 4
chr9_+_32306862 0.21 ENSDART00000078513
mob4
MOB family member 4, phocein
chr14_+_6429399 0.20 ENSDART00000149783
ENSDART00000148461
abca1b
ATP-binding cassette, sub-family A (ABC1), member 1B
chr2_+_21185903 0.19 ENSDART00000131369
si:dkey-29d8.3
si:dkey-29d8.3
chr15_+_17722054 0.18 ENSDART00000191390
ENSDART00000169550
si:ch211-213d14.1
si:ch211-213d14.1
chr2_-_32262287 0.18 ENSDART00000056621
ENSDART00000039717
fam49ba
family with sequence similarity 49, member Ba
chr16_+_29586004 0.18 ENSDART00000149520
mcl1b
MCL1, BCL2 family apoptosis regulator b
chr17_+_16423721 0.18 ENSDART00000064233
efcab11
EF-hand calcium binding domain 11
chr3_+_52145511 0.17 ENSDART00000078485
adgre14
adhesion G protein-coupled receptor E14
chr9_+_45680802 0.17 ENSDART00000036369
asb1
ankyrin repeat and SOCS box containing 1
chr12_-_35105670 0.16 ENSDART00000153034
si:ch73-127m5.2
si:ch73-127m5.2
chr14_+_37545341 0.16 ENSDART00000105588
pcdh1b
protocadherin 1b
chr24_+_9475809 0.16 ENSDART00000132688
si:ch211-285f17.1
si:ch211-285f17.1
chr20_-_42534153 0.16 ENSDART00000061122
rfx6
regulatory factor X, 6
chr5_-_38107741 0.16 ENSDART00000156853
si:ch211-284e13.14
si:ch211-284e13.14
chr10_-_8041948 0.14 ENSDART00000059017
nfkbil1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr25_-_12982193 0.14 ENSDART00000159617
ccl39.5
chemokine (C-C motif) ligand 39, duplicate 5
chr3_-_23470986 0.14 ENSDART00000113135
msl1a
male-specific lethal 1 homolog a (Drosophila)
chr3_-_33961589 0.13 ENSDART00000151533
ighd
immunoglobulin heavy constant delta
chr4_+_33012407 0.13 ENSDART00000151873
si:dkey-26h11.2
si:dkey-26h11.2
chr5_-_62317496 0.13 ENSDART00000180089
zgc:85789
zgc:85789
chr3_+_9588705 0.13 ENSDART00000172543
ENSDART00000104875
trap1
TNF receptor-associated protein 1
chr5_-_7513082 0.12 ENSDART00000158913
bmpr1ba
bone morphogenetic protein receptor, type IBa
chr21_-_30166097 0.12 ENSDART00000130676
hbegfb
heparin-binding EGF-like growth factor b
chr22_+_29087308 0.12 ENSDART00000186776
ENSDART00000178615
ENSDART00000150811
ENSDART00000150489
pla2g6
phospholipase A2, group VI (cytosolic, calcium-independent)
chr15_-_20779624 0.10 ENSDART00000181936
tpst1
tyrosylprotein sulfotransferase 1
chr3_-_40976463 0.10 ENSDART00000128450
ENSDART00000018676
cyp3c1
cytochrome P450, family 3, subfamily c, polypeptide 1
chr21_+_43171013 0.10 ENSDART00000151362
zcchc10
zinc finger, CCHC domain containing 10
chr21_-_1012269 0.09 ENSDART00000159835
CABZ01057159.1

chr14_+_6962271 0.09 ENSDART00000148447
ENSDART00000149114
ENSDART00000149492
ENSDART00000148394
hnrnpaba
heterogeneous nuclear ribonucleoprotein A/Ba
chr25_+_10987817 0.09 ENSDART00000156529
si:dkey-52p2.5
si:dkey-52p2.5
chr22_+_1853999 0.08 ENSDART00000163288
znf1174
zinc finger protein 1174
chr13_+_40034176 0.08 ENSDART00000189797
golga7bb
golgin A7 family, member Bb
chr15_+_11683114 0.07 ENSDART00000168233
si:dkey-31c13.1
si:dkey-31c13.1
chr8_-_13486258 0.07 ENSDART00000137459
pimr104
Pim proto-oncogene, serine/threonine kinase, related 104
chr21_+_30662263 0.06 ENSDART00000154758
ENSDART00000138664
clcn5a
chloride channel, voltage-sensitive 5a
chr5_-_30704390 0.06 ENSDART00000016709
ift22
intraflagellar transport 22 homolog (Chlamydomonas)
chr20_+_34717403 0.06 ENSDART00000034252
pnocb
prepronociceptin b
chr18_-_40905901 0.06 ENSDART00000064848
pglyrp5
peptidoglycan recognition protein 5
chr22_+_17118225 0.06 ENSDART00000135604
frem1b
Fras1 related extracellular matrix 1b
chr24_+_38658334 0.06 ENSDART00000155735
si:ch73-70c5.1
si:ch73-70c5.1
chr21_+_14511685 0.05 ENSDART00000102099
CR392036.1

chr7_+_4922104 0.05 ENSDART00000135154
si:dkey-28d5.11
si:dkey-28d5.11
chr4_-_37479395 0.05 ENSDART00000168299
ENSDART00000157864
si:dkey-106c17.2
si:dkey-106c17.2
chr1_-_50611031 0.05 ENSDART00000148285
ppm1k
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr2_-_51593835 0.04 ENSDART00000168072
si:ch211-9d9.7
si:ch211-9d9.7
chr1_-_43987873 0.04 ENSDART00000108821
CR385050.1

chr20_-_45062514 0.04 ENSDART00000183529
ENSDART00000182955
klhl29
kelch-like family member 29
chr22_-_8499778 0.04 ENSDART00000142219
si:ch73-27e22.4
si:ch73-27e22.4
chr25_+_12849609 0.04 ENSDART00000168144
ccl33.2
chemokine (C-C motif) ligand 33, duplicate 2
chr8_-_13454281 0.04 ENSDART00000141959
CR354547.2

chr16_+_4838808 0.03 ENSDART00000179363
ibtk
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr15_+_29728377 0.02 ENSDART00000099958
zgc:153372
zgc:153372
chr10_-_29733194 0.02 ENSDART00000149252
si:ch73-261i21.2
si:ch73-261i21.2
chr1_-_2061419 0.01 ENSDART00000058878
oxgr1a.3
oxoglutarate (alpha-ketoglutarate) receptor 1a, tandem duplicate 3
chr1_-_11519934 0.01 ENSDART00000162060
sdk1b
sidekick cell adhesion molecule 1b
chr25_+_10416583 0.01 ENSDART00000073907
ehf
ets homologous factor
chr22_+_9110998 0.01 ENSDART00000141520
nlrp15
NACHT, LRR and PYD domains-containing protein 15
chr18_+_7204378 0.00 ENSDART00000142905
vwf
von Willebrand factor

Network of associatons between targets according to the STRING database.

First level regulatory network of sox18

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0051026 meiotic DNA repair synthesis(GO:0000711) chiasma assembly(GO:0051026)
0.2 0.5 GO:0010265 SCF complex assembly(GO:0010265)
0.2 0.5 GO:0018872 arsonoacetate metabolic process(GO:0018872)
0.1 0.9 GO:0000455 enzyme-directed rRNA pseudouridine synthesis(GO:0000455)
0.1 0.4 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.1 0.4 GO:0060829 negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
0.1 0.5 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.1 0.4 GO:0003096 renal sodium ion transport(GO:0003096) renal sodium ion absorption(GO:0070294)
0.1 0.4 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866) positive regulation of triglyceride biosynthetic process(GO:0010867)
0.1 0.3 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.1 0.5 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.1 0.8 GO:0090309 methylation-dependent chromatin silencing(GO:0006346) positive regulation of chromatin silencing(GO:0031937) regulation of methylation-dependent chromatin silencing(GO:0090308) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.1 0.3 GO:1990108 protein linear deubiquitination(GO:1990108)
0.1 0.3 GO:0035988 chondrocyte proliferation(GO:0035988)
0.1 0.2 GO:0035773 insulin secretion involved in cellular response to glucose stimulus(GO:0035773) regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.0 0.5 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.0 0.5 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 0.3 GO:0003160 endocardium morphogenesis(GO:0003160)
0.0 0.5 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0 0.5 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.1 GO:0061400 positive regulation of transcription from RNA polymerase II promoter in response to calcium ion(GO:0061400)
0.0 0.2 GO:0033700 phospholipid efflux(GO:0033700)
0.0 0.8 GO:0016575 histone deacetylation(GO:0016575)
0.0 1.0 GO:0006119 oxidative phosphorylation(GO:0006119)
0.0 0.1 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.1 GO:0006478 protein sulfation(GO:0006477) peptidyl-tyrosine sulfation(GO:0006478)
0.0 0.1 GO:0007176 regulation of epidermal growth factor-activated receptor activity(GO:0007176)
0.0 0.2 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.4 GO:0048264 determination of ventral identity(GO:0048264)
0.0 0.2 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.2 GO:0006378 mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0043073 germ cell nucleus(GO:0043073)
0.1 0.4 GO:1990923 PET complex(GO:1990923)
0.1 0.4 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.1 0.5 GO:0005845 mRNA cap binding complex(GO:0005845)
0.0 0.3 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.5 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.0 0.8 GO:0032040 small-subunit processome(GO:0032040)
0.0 0.4 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.7 GO:0090544 BAF-type complex(GO:0090544)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.4 GO:0008278 cohesin complex(GO:0008278)
0.0 0.2 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.5 GO:0016605 PML body(GO:0016605)
0.0 0.3 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.5 GO:0030532 small nuclear ribonucleoprotein complex(GO:0030532)
0.0 0.8 GO:0000118 histone deacetylase complex(GO:0000118)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0017064 fatty acid amide hydrolase activity(GO:0017064)
0.2 0.5 GO:0030791 arsenite methyltransferase activity(GO:0030791) methylarsonite methyltransferase activity(GO:0030792)
0.2 0.5 GO:0045174 glutathione dehydrogenase (ascorbate) activity(GO:0045174)
0.2 0.5 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 0.8 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.1 0.5 GO:0070698 type I activin receptor binding(GO:0070698)
0.1 0.2 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.1 0.3 GO:0008469 histone-arginine N-methyltransferase activity(GO:0008469)
0.1 0.4 GO:0034584 piRNA binding(GO:0034584)
0.0 0.9 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.2 GO:0090556 phospholipid-translocating ATPase activity(GO:0004012) phosphatidylcholine-translocating ATPase activity(GO:0090554) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.0 0.3 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 1.0 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.5 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.5 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.4 GO:0019870 chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870)
0.0 0.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.2 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.5 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.4 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.1 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.0 0.5 GO:0017069 snRNA binding(GO:0017069)
0.0 0.2 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.1 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.0 0.2 GO:0031726 CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.3 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.5 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.5 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.6 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.1 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE