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PRJNA195909:zebrafish embryo and larva development

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Results for tcf7l1a+tcf7l1b+tcf7l2

Z-value: 1.07

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Transcription factors associated with tcf7l1a+tcf7l1b+tcf7l2

Gene Symbol Gene ID Gene Info
ENSDARG00000004415 transcription factor 7 like 2
ENSDARG00000007369 transcription factor 7 like 1b
ENSDARG00000038159 transcription factor 7 like 1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tcf7l2dr11_v1_chr12_-_31009315_310093150.987.0e-06Click!
tcf7l1bdr11_v1_chr8_-_52230115_52230115-0.863.1e-03Click!
tcf7l1adr11_v1_chr10_-_42297889_42297889-0.713.2e-02Click!

Activity profile of tcf7l1a+tcf7l1b+tcf7l2 motif

Sorted Z-values of tcf7l1a+tcf7l1b+tcf7l2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_55131289 3.36 ENSDART00000111585

chr16_+_23913943 3.34 ENSDART00000175404
ENSDART00000129525
apolipoprotein A-IV b, tandem duplicate 1
chr14_-_25949951 3.05 ENSDART00000141304
secreted protein, acidic, cysteine-rich (osteonectin)
chr3_+_55122662 2.54 ENSDART00000128380
hemoglobin beta embryonic-1.2
chr3_+_55114097 2.31 ENSDART00000121686
hemoglobin beta embryonic-1.1
chr16_-_45917322 2.27 ENSDART00000060822
antifreeze protein type IV
chr7_+_39446247 2.22 ENSDART00000033610
ENSDART00000099015
troponin T type 3b (skeletal, fast)
chr10_-_39011514 1.92 ENSDART00000075123
Purkinje cell protein 4a
chr16_-_45917683 1.91 ENSDART00000184289
antifreeze protein type IV
chr3_+_27027781 1.65 ENSDART00000065495
epithelial membrane protein 2
chr7_+_38750871 1.63 ENSDART00000114238
ENSDART00000052325
ENSDART00000137001
coagulation factor II (thrombin)
chr20_-_40451115 1.57 ENSDART00000075092
protein kinase (cAMP-dependent, catalytic) inhibitor beta
chr25_+_21829777 1.56 ENSDART00000027393
creatine kinase, mitochondrial 1
chr4_-_17409533 1.56 ENSDART00000011943
phenylalanine hydroxylase
chr24_-_32408404 1.54 ENSDART00000144157
si:ch211-56a11.2
chr13_-_31441042 1.51 ENSDART00000076571
reticulon 1a
chr15_+_32727848 1.49 ENSDART00000161361
periostin, osteoblast specific factor b
chr10_+_32104305 1.46 ENSDART00000099880
wingless-type MMTV integration site family, member 11, related
chr12_-_31103187 1.43 ENSDART00000005562
ENSDART00000031408
ENSDART00000125046
ENSDART00000009237
ENSDART00000122972
ENSDART00000153068
transcription factor 7 like 2
chr22_-_16042243 1.41 ENSDART00000062633
sphingosine-1-phosphate receptor 1
chr21_-_41147818 1.38 ENSDART00000167339
ENSDART00000192730
muscle segment homeobox 2b
chr11_-_42099645 1.36 ENSDART00000173312
abhydrolase domain containing 6a
chr9_+_7548533 1.34 ENSDART00000081543
protein tyrosine phosphatase, receptor type, Na
chr6_-_26559921 1.34 ENSDART00000104532
SRY (sex determining region Y)-box 14
chr20_-_48485354 1.33 ENSDART00000124040
ENSDART00000148437
insulinoma-associated 1a
chr23_-_26077038 1.32 ENSDART00000126299
GDP dissociation inhibitor 1
chr6_+_49255706 1.28 ENSDART00000156866
si:dkey-183k8.2
chr1_+_26356360 1.27 ENSDART00000113020
tet methylcytosine dioxygenase 2
chr24_+_11334733 1.24 ENSDART00000147552
ENSDART00000143171
si:dkey-12l12.1
chr20_+_22666548 1.21 ENSDART00000147520
ligand of numb-protein X 1
chr8_-_41228530 1.18 ENSDART00000165949
ENSDART00000173055
fumarylacetoacetate hydrolase domain containing 2A
chr1_-_29045426 1.16 ENSDART00000019770
glycoprotein M6Ba
chr14_+_24277556 1.15 ENSDART00000122660
heterogeneous nuclear ribonucleoprotein A0a
chr6_+_52804267 1.14 ENSDART00000065681
matrilin 4
chr11_-_23219367 1.13 ENSDART00000003646
opticin
chr1_-_36151377 1.12 ENSDART00000037516
zinc finger protein 827
chr6_-_57938043 1.12 ENSDART00000171073
TOX high mobility group box family member 2
chr5_+_42280372 1.10 ENSDART00000142855
T-box 6, like
chr1_-_40911332 1.07 ENSDART00000027463
H6 family homeobox 4
chr22_-_26100282 1.07 ENSDART00000166075
platelet-derived growth factor alpha polypeptide a
chr23_-_29824146 1.06 ENSDART00000020616
zgc:194189
chr7_-_41554047 1.05 ENSDART00000174144
plexin domain containing 2
chr6_-_40429411 1.05 ENSDART00000156005
ENSDART00000156357
si:dkey-28n18.9
chr7_-_9803154 1.04 ENSDART00000055593
aldehyde dehydrogenase 1 family, member A3
chr8_+_13106760 1.04 ENSDART00000029308
integrin, beta 4
chr1_+_26356205 1.03 ENSDART00000190064
ENSDART00000176380
tet methylcytosine dioxygenase 2
chr16_+_26774182 1.03 ENSDART00000042895
cadherin 17, LI cadherin (liver-intestine)
chr25_-_22187397 1.03 ENSDART00000123211
ENSDART00000139110
plakophilin 3a
chr7_+_57836841 1.00 ENSDART00000136175
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1
chr22_-_26005894 0.99 ENSDART00000105088
platelet-derived growth factor alpha polypeptide a
chr12_+_5129245 0.97 ENSDART00000169073
phosphodiesterase 6C, cGMP-specific, cone, alpha prime
chr19_-_9522548 0.96 ENSDART00000045245
inhibitor of growth family, member 4
chr21_+_19834072 0.96 ENSDART00000147555
coiled-coil domain containing 80 like 2
chr16_+_32559821 0.96 ENSDART00000093250
POU class 3 homeobox 2b
chr8_+_16407884 0.95 ENSDART00000133742
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr4_+_69619 0.94 ENSDART00000164425
MANSC domain containing 1
chr20_-_9436521 0.93 ENSDART00000133000
zgc:101840
chr5_-_24333684 0.91 ENSDART00000051553
zinc finger protein 703
chr7_-_54677143 0.91 ENSDART00000163748
cyclin D1
chr2_+_33368414 0.91 ENSDART00000077462
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr13_-_31647323 0.91 ENSDART00000135381
SIX homeobox 4a
chr15_-_2188332 0.90 ENSDART00000138941
ENSDART00000009564
short stature homeobox 2
chr5_+_10015002 0.88 ENSDART00000140570
solute carrier family 2 (facilitated glucose transporter), member 11b
chr11_+_14622379 0.87 ENSDART00000112589
ephrin-A2b
chr7_-_37622370 0.85 ENSDART00000173523
naked cuticle homolog 1 (Drosophila)
chr7_-_37622153 0.84 ENSDART00000052379
naked cuticle homolog 1 (Drosophila)
chr19_+_48049202 0.83 ENSDART00000027158
proteasome 26S subunit, non-ATPase 3
chr20_+_34455645 0.83 ENSDART00000135789
methyltransferase like 11B
chr18_+_45796096 0.83 ENSDART00000087070
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chr2_+_22042745 0.82 ENSDART00000132039
thymocyte selection-associated high mobility group box
chr5_-_29570141 0.81 ENSDART00000043259
ectonucleoside triphosphate diphosphohydrolase 2a, tandem duplicate 2
chr1_-_42779075 0.80 ENSDART00000133917
leucine rich repeat transmembrane neuronal 1
chr24_+_6107901 0.80 ENSDART00000156419
si:ch211-37e10.2
chr9_-_9992697 0.79 ENSDART00000123415
UDP glucuronosyltransferase 1 family a, b
chr19_+_31771270 0.78 ENSDART00000147474
stathmin 2b
chr7_+_69653981 0.77 ENSDART00000090165
Fras1 related extracellular matrix 1a
chr15_-_8309207 0.77 ENSDART00000143880
ENSDART00000061351
tumor necrosis factor receptor superfamily, member 19
chr14_+_15064870 0.76 ENSDART00000167075
NK1 transcription factor related 2-like,b
chr20_-_42702832 0.76 ENSDART00000134689
ENSDART00000045816
plasminogen
chr20_+_25225112 0.76 ENSDART00000153088
ENSDART00000127291
ENSDART00000130494
monooxygenase, DBH-like 1
chr3_+_12484008 0.76 ENSDART00000182229
vasorin b
chr17_-_20897250 0.74 ENSDART00000088106
ankyrin 3b
chr17_-_14816465 0.73 ENSDART00000156326
ENSDART00000156287
nidogen 2a (osteonidogen)
chr5_-_65000312 0.72 ENSDART00000192893
zgc:110283
chr1_+_2190714 0.72 ENSDART00000132126
muscleblind-like splicing regulator 2
chr24_+_23742690 0.72 ENSDART00000130162
transcription factor 24
chr19_+_29798064 0.69 ENSDART00000167803
ENSDART00000051804
MARCKS-like 1b
chr9_+_28693592 0.68 ENSDART00000110198
zgc:162780
chr1_-_8428736 0.68 ENSDART00000138435
ENSDART00000121823
synaptogyrin 3b
chr9_+_17306162 0.68 ENSDART00000075926
sciellin
chr4_-_77432218 0.68 ENSDART00000158683
solute carrier organic anion transporter family, member 1D1
chr23_-_20764227 0.68 ENSDART00000089750
zinc finger protein 362b
chr19_+_42983613 0.68 ENSDART00000033724
fatty acid binding protein 3, muscle and heart
chr18_-_44888375 0.67 ENSDART00000160506
si:ch211-71n6.4
chr15_-_12545683 0.66 ENSDART00000162807
sodium channel, voltage-gated, type II, beta
chr10_-_17466990 0.66 ENSDART00000147794
5'-nucleotidase, cytosolic II, like 1
chr1_+_17376922 0.64 ENSDART00000145068
FAT atypical cadherin 1a
chr8_-_38105053 0.64 ENSDART00000131546
adhesion G protein-coupled receptor A2
chr21_-_25522510 0.64 ENSDART00000162711
connector enhancer of kinase suppressor of Ras 2b
chr21_-_17482465 0.63 ENSDART00000004548
BarH-like homeobox 1b
chr6_+_58915889 0.60 ENSDART00000083628
DNA-damage-inducible transcript 3
chr1_-_42778510 0.60 ENSDART00000190172
leucine rich repeat transmembrane neuronal 1
chr23_-_45705525 0.58 ENSDART00000148959
endothelin receptor type Ab
chr13_-_18835254 0.58 ENSDART00000147579
ENSDART00000146795
leucine zipper, putative tumor suppressor 2a
chr15_+_7086327 0.57 ENSDART00000114560
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
chr20_+_43942278 0.57 ENSDART00000100571
chloride intracellular channel 5b
chr6_-_6976096 0.57 ENSDART00000151822
ENSDART00000039443
ENSDART00000177960
tubulin, alpha 8 like 4
chr17_+_27176243 0.56 ENSDART00000162527
si:ch211-160f23.7
chr10_-_31562695 0.55 ENSDART00000186456
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr5_+_34407763 0.54 ENSDART00000188849
ENSDART00000145127
laminin, gamma 3
chr7_+_34492744 0.54 ENSDART00000109635
ENSDART00000173844
calmodulin-like 4a
chr13_+_27073901 0.54 ENSDART00000146227
solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
chr16_-_383664 0.53 ENSDART00000051693
iroquois homeobox 4a
chr16_+_16933002 0.53 ENSDART00000173163
myosin, heavy chain 14, non-muscle
chr14_+_22447662 0.53 ENSDART00000161776
sosondowah ankyrin repeat domain family member Ab
chr9_-_9998087 0.53 ENSDART00000124423
UDP glucuronosyltransferase 1 family a, b
chr20_+_43083745 0.52 ENSDART00000139014
ENSDART00000153438
monooxygenase, DBH-like 1, like
chr8_+_16408385 0.52 ENSDART00000177231
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr1_+_36674584 0.52 ENSDART00000186772
ENSDART00000192274
endothelin receptor type Aa
chr20_+_30445971 0.50 ENSDART00000153150
myelin transcription factor 1-like, a
chr22_+_35930526 0.49 ENSDART00000169242

chr2_+_30379650 0.49 ENSDART00000129542
cysteine-rich secretory protein LCCL domain containing 1b
chr23_+_18722915 0.48 ENSDART00000025057
myosin, heavy chain 7B, cardiac muscle, beta b
chr25_+_7229046 0.48 ENSDART00000149965
ENSDART00000041820
leucine rich repeat and Ig domain containing 1a
chr4_+_10366532 0.47 ENSDART00000189901
potassium voltage-gated channel, Shal-related subfamily, member 2
chr8_-_34051548 0.46 ENSDART00000105204
pre-B-cell leukemia homeobox 3b
chr8_-_34052019 0.46 ENSDART00000040126
ENSDART00000159208
ENSDART00000048994
ENSDART00000098822
pre-B-cell leukemia homeobox 3b
chr5_+_27442247 0.46 ENSDART00000184129
lysyl oxidase-like 2b
chr16_+_19014886 0.46 ENSDART00000079298
si:ch211-254p10.2
chr5_-_27867657 0.45 ENSDART00000112495
transcriptional and immune response regulator a
chr19_-_8880688 0.45 ENSDART00000039629
cugbp, Elav-like family member 3a
chr8_-_25329967 0.44 ENSDART00000139682
EPS8-like 3b
chr19_-_32487469 0.44 ENSDART00000050130
guanosine monophosphate reductase
chr25_+_14092871 0.44 ENSDART00000067239
guanylate cyclase activator 1g
chr22_+_13917311 0.43 ENSDART00000022654
SH3-domain binding protein 4a
chr13_+_3252950 0.43 ENSDART00000020671
peripherin 2b (retinal degeneration, slow)
chr5_-_22082918 0.42 ENSDART00000020908
zinc finger, C4H2 domain containing
chr21_-_37889727 0.41 ENSDART00000163612
ENSDART00000180958
gamma-aminobutyric acid (GABA) A receptor, beta 4
chr14_+_22591624 0.41 ENSDART00000108987
GDNF family receptor alpha 4b
chr17_-_20897407 0.40 ENSDART00000149481
ankyrin 3b
chr7_+_38936132 0.40 ENSDART00000173945
cAMP responsive element binding protein 3-like 1
chr15_-_163586 0.40 ENSDART00000163597
septin-4
chr24_-_6546479 0.38 ENSDART00000160538
Rho GTPase activating protein 21a
chr2_-_43083749 0.38 ENSDART00000084303
ENSDART00000145494
potassium voltage-gated channel, KQT-like subfamily, member 3
chr20_+_37294112 0.38 ENSDART00000076293
ENSDART00000140450
connexin 23
chr10_-_31563049 0.38 ENSDART00000023575
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr23_+_28077953 0.37 ENSDART00000186122
ENSDART00000111570
solute carrier family 26, member 10
chr1_-_39976492 0.35 ENSDART00000181680
storkhead box 2a
chr20_+_25597527 0.35 ENSDART00000130242
cytochrome P450, family 2, subfamily J, polypeptide 20
chr1_-_681116 0.35 ENSDART00000165894
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr5_+_45008418 0.35 ENSDART00000189882
doublesex and mab-3 related transcription factor 2a
chr21_-_25522906 0.34 ENSDART00000110923
connector enhancer of kinase suppressor of Ras 2b
chr13_+_22476742 0.33 ENSDART00000078759
ENSDART00000130101
ENSDART00000137220
ENSDART00000133065
ENSDART00000147348
LIM domain binding 3a
chr11_+_40043569 0.33 ENSDART00000130278
si:dkey-264d12.1
chr3_-_32299892 0.32 ENSDART00000181472
si:dkey-16p21.7
chr23_-_39784368 0.32 ENSDART00000110282
si:ch211-286f9.2
chr19_+_43119698 0.31 ENSDART00000167847
ENSDART00000186962
ENSDART00000187305
eukaryotic translation elongation factor 1 alpha 1, like 1
chr9_+_10014817 0.31 ENSDART00000132065
neurexophilin 2a
chr11_-_29818866 0.31 ENSDART00000176367
cytochrome b-245, beta polypeptide (chronic granulomatous disease)
chr20_+_10727022 0.31 ENSDART00000104185
si:ch211-182e10.4
chr24_+_11105786 0.30 ENSDART00000175182
prolactin releasing hormone 2
chr9_-_3671911 0.30 ENSDART00000102900
Sp5 transcription factor a
chr16_+_17389116 0.30 ENSDART00000103750
ENSDART00000173448
family with sequence similarity 131, member Bb
chr4_-_2036620 0.30 ENSDART00000150490
si:dkey-97m3.1
chr13_-_31829786 0.30 ENSDART00000138667
SERTA domain containing 4
chr21_-_20328375 0.29 ENSDART00000079593
solute carrier family 26 (anion exchanger), member 1
chr2_-_34483597 0.29 ENSDART00000133224
bone morphogenetic protein/retinoic acid inducible neural-specific 2
chr8_-_30242706 0.29 ENSDART00000139864
ENSDART00000143809
zgc:162939
chr9_+_29994439 0.29 ENSDART00000012447
transmembrane protein 30C
chr7_-_18554603 0.29 ENSDART00000108938
Myb/SANT-like DNA-binding domain containing 1
chr20_+_39283849 0.28 ENSDART00000002481
ENSDART00000146683
scavenger receptor class A, member 3
chr5_-_52921532 0.28 ENSDART00000160566

chr18_-_34143189 0.28 ENSDART00000079341
phospholipase C, eta 1
chr15_-_31588162 0.28 ENSDART00000153598
heat shock 105/110 protein 1
chr2_-_59376399 0.27 ENSDART00000137134
finTRIM family, member 38
chr2_-_59376735 0.27 ENSDART00000193624
finTRIM family, member 38
chr3_+_41714966 0.27 ENSDART00000155440
eukaryotic translation initiation factor 3, subunit Ba
chr4_-_880415 0.27 ENSDART00000149162
crystallin beta-gamma domain containing 1b
chr9_+_10014514 0.26 ENSDART00000185590
neurexophilin 2a
chr11_+_6080528 0.24 ENSDART00000183099
Usher syndrome 1C binding protein 1
chr3_-_23643751 0.24 ENSDART00000078425
ENSDART00000140264
even-skipped-like1
chr23_+_33907899 0.24 ENSDART00000159445
citrate synthase
chr20_+_36234335 0.24 ENSDART00000193484
ENSDART00000181664
cornichon family AMPA receptor auxiliary protein 3
chr15_+_24691088 0.24 ENSDART00000110618
si:dkey-151p21.7
chr22_+_21324398 0.24 ENSDART00000168509
SHC (Src homology 2 domain containing) transforming protein 2
chr9_-_35155089 0.23 ENSDART00000077901
amyloid beta (A4) precursor protein b
chr1_+_35862550 0.23 ENSDART00000132118
si:ch211-194g2.4
chr13_+_28732101 0.22 ENSDART00000015773
LIM domain binding 1a
chr6_+_15762647 0.22 ENSDART00000127133
ENSDART00000128939
IQ motif containing with AAA domain 1
chr9_+_44034790 0.21 ENSDART00000166110
ENSDART00000176954
integrin alpha 4
chr25_+_35020529 0.21 ENSDART00000158016
filamin C, gamma a (actin binding protein 280)
chr19_+_42469058 0.21 ENSDART00000076915
si:dkey-166k12.1
chr6_-_29105727 0.20 ENSDART00000184355
family with sequence similarity 69, member Ab
chr12_+_48204891 0.20 ENSDART00000190534
ENSDART00000164427
nodal-related 2
chr19_+_43119014 0.20 ENSDART00000023156
eukaryotic translation elongation factor 1 alpha 1, like 1
chr12_+_6465557 0.20 ENSDART00000066477
ENSDART00000122271
dickkopf WNT signaling pathway inhibitor 1b
chr21_-_40782393 0.19 ENSDART00000075808
amyloid beta (A4) precursor protein-binding, family B, member 3
chr8_+_36803415 0.19 ENSDART00000111680
IQ motif and Sec7 domain 2b
chr17_+_5800286 0.19 ENSDART00000175504
retinitis pigmentosa 1-like 1a
chr24_+_15897717 0.18 ENSDART00000105956
neuropilin (NRP) and tolloid (TLL)-like 1, like

Network of associatons between targets according to the STRING database.

First level regulatory network of tcf7l1a+tcf7l1b+tcf7l2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0001977 renal system process involved in regulation of blood volume(GO:0001977) renal system process involved in regulation of systemic arterial blood pressure(GO:0003071) regulation of glomerular filtration(GO:0003093)
0.5 1.4 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376)
0.4 1.3 GO:0046333 octopamine biosynthetic process(GO:0006589) dopamine catabolic process(GO:0042420) norepinephrine biosynthetic process(GO:0042421) octopamine metabolic process(GO:0046333)
0.4 1.7 GO:0046823 regulation of protein import into nucleus(GO:0042306) negative regulation of protein import into nucleus(GO:0042308) negative regulation of nucleocytoplasmic transport(GO:0046823) negative regulation of protein localization to nucleus(GO:1900181) regulation of protein import(GO:1904589) negative regulation of protein import(GO:1904590)
0.4 2.1 GO:0003261 cardiac muscle progenitor cell migration to the midline involved in heart field formation(GO:0003261)
0.4 1.2 GO:0051580 regulation of neurotransmitter uptake(GO:0051580) negative regulation of anion transport(GO:1903792)
0.4 1.4 GO:0010226 response to lithium ion(GO:0010226)
0.3 2.3 GO:0019857 5-methylcytosine catabolic process(GO:0006211) 5-methylcytosine metabolic process(GO:0019857)
0.3 0.6 GO:0003319 cardioblast migration to the midline involved in heart rudiment formation(GO:0003319)
0.3 1.4 GO:0014045 establishment of endothelial blood-brain barrier(GO:0014045)
0.3 0.8 GO:0006480 N-terminal protein amino acid methylation(GO:0006480)
0.3 1.6 GO:0006953 acute-phase response(GO:0006953)
0.3 0.8 GO:0042730 fibrinolysis(GO:0042730)
0.2 0.9 GO:0060092 regulation of synaptic transmission, glycinergic(GO:0060092)
0.2 1.3 GO:0060221 retinal rod cell differentiation(GO:0060221)
0.2 0.9 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.2 0.9 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 0.6 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.1 0.8 GO:0033986 response to methanol(GO:0033986) cellular response to methanol(GO:0071405)
0.1 1.6 GO:0006559 L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.1 1.6 GO:0042396 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.1 3.3 GO:0060030 dorsal convergence(GO:0060030)
0.1 0.5 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.1 2.4 GO:0015671 oxygen transport(GO:0015671)
0.1 0.9 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.1 0.4 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.1 3.1 GO:0032474 otolith morphogenesis(GO:0032474) semicircular canal morphogenesis(GO:0048752)
0.1 2.2 GO:0006942 regulation of striated muscle contraction(GO:0006942)
0.1 0.5 GO:0035176 social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
0.1 0.8 GO:0015886 heme transport(GO:0015886) iron coordination entity transport(GO:1901678)
0.1 1.5 GO:0016203 muscle attachment(GO:0016203)
0.1 0.9 GO:0071679 commissural neuron axon guidance(GO:0071679)
0.1 0.4 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.1 0.3 GO:0019532 oxalate transport(GO:0019532)
0.1 0.6 GO:0051013 microtubule severing(GO:0051013)
0.1 0.3 GO:0006570 tyrosine metabolic process(GO:0006570)
0.1 0.2 GO:0002568 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.1 0.5 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.1 1.0 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.2 GO:0055057 neuroblast division(GO:0055057)
0.0 0.9 GO:0030316 osteoclast differentiation(GO:0030316)
0.0 0.2 GO:0061011 hepatic duct development(GO:0061011)
0.0 1.5 GO:0010921 regulation of phosphatase activity(GO:0010921)
0.0 0.3 GO:0042554 superoxide anion generation(GO:0042554)
0.0 0.3 GO:0003313 heart rudiment development(GO:0003313)
0.0 1.4 GO:0061386 closure of optic fissure(GO:0061386)
0.0 0.7 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.8 GO:0008345 larval locomotory behavior(GO:0008345) larval behavior(GO:0030537)
0.0 1.0 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 0.6 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 0.8 GO:1903845 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.0 0.3 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.4 GO:0048923 posterior lateral line neuromast hair cell differentiation(GO:0048923)
0.0 0.2 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.0 0.2 GO:0046716 muscle cell cellular homeostasis(GO:0046716)
0.0 0.5 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 3.3 GO:0042157 lipoprotein metabolic process(GO:0042157)
0.0 1.0 GO:0001885 endothelial cell development(GO:0001885)
0.0 0.4 GO:0006144 purine nucleobase metabolic process(GO:0006144)
0.0 0.4 GO:0008272 sulfate transport(GO:0008272)
0.0 0.2 GO:0045471 response to ethanol(GO:0045471)
0.0 0.4 GO:0048665 neuron fate specification(GO:0048665)
0.0 0.1 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.0 0.2 GO:0014823 response to activity(GO:0014823)
0.0 0.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.9 GO:0008016 regulation of heart contraction(GO:0008016)
0.0 0.5 GO:0031103 axon regeneration(GO:0031103)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.4 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.2 2.4 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 0.6 GO:1990909 Wnt signalosome(GO:1990909)
0.1 0.4 GO:1902560 GMP reductase complex(GO:1902560)
0.1 0.8 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 2.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 1.3 GO:0030667 secretory granule membrane(GO:0030667)
0.1 1.0 GO:0030057 desmosome(GO:0030057)
0.1 2.3 GO:0005861 troponin complex(GO:0005861)
0.1 0.4 GO:0043194 axon initial segment(GO:0043194)
0.1 0.9 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.3 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 1.3 GO:0008305 integrin complex(GO:0008305)
0.0 2.8 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.7 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.7 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 1.0 GO:0016342 catenin complex(GO:0016342)
0.0 1.3 GO:0030141 secretory granule(GO:0030141)
0.0 0.1 GO:0033268 node of Ranvier(GO:0033268)
0.0 1.8 GO:0005604 basement membrane(GO:0005604)
0.0 4.8 GO:0031012 extracellular matrix(GO:0031012)
0.0 1.0 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.5 GO:0043204 perikaryon(GO:0043204)
0.0 0.3 GO:0016282 eukaryotic 43S preinitiation complex(GO:0016282)
0.0 0.4 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.6 GO:0030496 midbody(GO:0030496)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0005093 Rab GDP-dissociation inhibitor activity(GO:0005093)
0.4 1.3 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.3 2.3 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.3 0.8 GO:0071885 N-terminal protein N-methyltransferase activity(GO:0071885)
0.2 2.1 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.2 2.2 GO:0030172 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.2 2.4 GO:0031720 haptoglobin binding(GO:0031720)
0.2 1.4 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.2 1.6 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.2 1.5 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.2 0.7 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.2 0.9 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.2 1.1 GO:0004962 endothelin receptor activity(GO:0004962)
0.1 0.4 GO:0016657 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.1 0.8 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 1.6 GO:0016775 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.1 3.1 GO:0005518 collagen binding(GO:0005518)
0.1 0.5 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 1.0 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.1 0.9 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 0.5 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 0.4 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.1 0.6 GO:0052812 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.1 0.5 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.8 GO:0045134 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.0 3.3 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.3 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.0 0.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.2 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.7 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.3 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.1 GO:0001607 neuromedin U receptor activity(GO:0001607)
0.0 0.2 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.7 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.2 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.1 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
0.0 0.9 GO:0098632 protein binding involved in cell adhesion(GO:0098631) protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.5 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 1.0 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.7 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 1.3 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 1.0 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 2.1 GO:0045296 cadherin binding(GO:0045296)
0.0 2.9 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.5 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.1 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.0 0.3 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.9 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.8 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.3 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.3 GO:0051371 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.0 0.1 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.0 0.2 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.0 0.9 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.1 GO:0032052 bile acid binding(GO:0032052)
0.0 0.4 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.9 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 0.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.2 GO:0010181 FMN binding(GO:0010181)
0.0 2.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.6 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 1.4 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 1.0 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 0.9 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 1.0 PID CONE PATHWAY Visual signal transduction: Cones
0.1 1.3 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 0.8 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 1.1 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 4.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.2 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.0 1.2 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 1.2 PID NOTCH PATHWAY Notch signaling pathway
0.0 1.3 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.6 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 0.5 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.5 PID E2F PATHWAY E2F transcription factor network
0.0 0.0 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.1 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 0.8 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.1 0.9 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 2.4 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.4 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 3.1 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.6 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.5 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.9 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.5 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.2 REACTOME SHC MEDIATED SIGNALLING Genes involved in SHC-mediated signalling
0.0 0.8 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.3 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.5 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.8 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 0.2 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.8 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides