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PRJNA207719: Tissue specific transcriptome profiling

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Results for drgx_arxb

Z-value: 0.72

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Transcription factors associated with drgx_arxb

Gene Symbol Gene ID Gene Info
ENSDARG00000069329 dorsal root ganglia homeobox
ENSDARG00000101523 aristaless related homeobox b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
arxbdr11_v1_chr21_-_40676224_406762240.894.2e-02Click!
drgxdr11_v1_chr13_+_30912117_309121170.622.6e-01Click!

Activity profile of drgx_arxb motif

Sorted Z-values of drgx_arxb motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_9669717 1.47 ENSDART00000004604
si:dkey-153k10.9
chr21_-_27881752 1.14 ENSDART00000132583
neurexin 2a
chr24_-_38079261 1.05 ENSDART00000105662
C-reactive protein 1
chr25_-_13381854 1.04 ENSDART00000164621
ENSDART00000169129
NDRG family member 4
chr4_-_14315855 1.02 ENSDART00000133325
neural EGFL like 2b
chr24_-_38384432 0.96 ENSDART00000140739
leucine rich repeat containing 4Bb
chr21_+_7582036 0.94 ENSDART00000135485
ENSDART00000027268
orthopedia homeobox a
chr7_+_26629084 0.86 ENSDART00000101044
ENSDART00000173765
heat shock factor binding protein 1a
chr8_-_7391721 0.82 ENSDART00000149836
LHFPL tetraspan subfamily member 4b
chr18_+_1703984 0.80 ENSDART00000114010
SLIT and NTRK-like family, member 3a
chr10_-_34772211 0.66 ENSDART00000145450
ENSDART00000134307
doublecortin-like kinase 1a
chr12_-_35386910 0.66 ENSDART00000153453
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1
chr20_-_20931197 0.61 ENSDART00000152726
BTB (POZ) domain containing 6b
chr13_-_29421331 0.61 ENSDART00000150228
choline O-acetyltransferase a
chr14_+_19258702 0.58 ENSDART00000187087
ENSDART00000005738
SLIT and NTRK-like family, member 2
chr15_+_22435460 0.57 ENSDART00000031976
transmembrane protein 136a
chr20_-_20930926 0.56 ENSDART00000123909
BTB (POZ) domain containing 6b
chr6_+_58698475 0.52 ENSDART00000056138
immunoglobulin superfamily, member 8
chr2_+_38554260 0.52 ENSDART00000171527
cadherin 24, type 2b
chr7_-_28148310 0.51 ENSDART00000044208
LIM domain only 1
chr23_-_12345764 0.50 ENSDART00000133956
phosphatase and actin regulator 3a
chr18_-_13121983 0.50 ENSDART00000092648
ribitol xylosyltransferase 1
chr22_+_10698549 0.50 ENSDART00000081228
abhydrolase domain containing 14A
chr9_+_34641237 0.49 ENSDART00000133996
short stature homeobox
chr3_+_46628885 0.48 ENSDART00000006602
phosphodiesterase 4A, cAMP-specific
chr9_-_51436377 0.47 ENSDART00000006612
T-box, brain, 1b
chr22_-_32507966 0.43 ENSDART00000104693
poly(rC) binding protein 4
chr6_+_40661703 0.42 ENSDART00000142492
enolase 1b, (alpha)
chr12_+_42436920 0.40 ENSDART00000177303
early B cell factor 3a
chr21_-_17482465 0.40 ENSDART00000004548
BarH-like homeobox 1b
chr6_+_40354424 0.40 ENSDART00000047416
solute carrier family 4, sodium bicarbonate cotransporter, member 8
chr17_+_18117029 0.39 ENSDART00000154646
ENSDART00000179739
B cell CLL/lymphoma 11Ba
chr9_-_27649406 0.39 ENSDART00000181270
ENSDART00000187112
syntaxin binding protein 5-like
chr1_+_25801648 0.35 ENSDART00000129471
guanylate cyclase 1 soluble subunit beta 1
chr9_+_29643036 0.35 ENSDART00000023210
ENSDART00000175160
tripartite motif containing 13
chr1_+_18811679 0.34 ENSDART00000078610
solute carrier family 25, member 51a
chr21_+_19008168 0.33 ENSDART00000136196
ENSDART00000128381
ENSDART00000176624
neurofilament, light polypeptide a
chr7_-_52334840 0.33 ENSDART00000174173

chr12_+_25432627 0.32 ENSDART00000011662
protein phosphatase, Mg2+/Mn2+ dependent, 1Bb
chr7_+_21859337 0.32 ENSDART00000159626
si:dkey-85k7.7
chr17_-_14726824 0.31 ENSDART00000162947
si:ch73-305o9.3
chr25_+_18964782 0.31 ENSDART00000017299
thymine DNA glycosylase, tandem duplicate 1
chr21_-_10446405 0.31 ENSDART00000167948
hyperpolarization activated cyclic nucleotide-gated potassium channel 1
chr9_+_36314867 0.31 ENSDART00000176763
low density lipoprotein receptor-related protein 1Bb
chr16_+_22654481 0.30 ENSDART00000179762
cholinergic receptor, nicotinic, beta 2b
chr12_-_47601845 0.30 ENSDART00000169548
ENSDART00000182889
regulator of G protein signaling 7b
chr3_+_3610140 0.30 ENSDART00000104977
protein interacting with prkca 1
chr16_-_27640995 0.28 ENSDART00000019658
NAC alpha domain containing
chr1_-_23110740 0.27 ENSDART00000171848
ENSDART00000086797
ENSDART00000189344
ENSDART00000190858
adhesion G protein-coupled receptor L3.1
chr1_+_53954230 0.26 ENSDART00000037729
ENSDART00000159900
centriole, cilia and spindle-associated protein a
chr10_+_40284003 0.25 ENSDART00000062795
ENSDART00000193825
ENSDART00000113582
G protein-coupled receptor kinase interacting ArfGAP 2b
chr17_-_26926577 0.25 ENSDART00000050202
regulator of calcineurin 3
chr12_+_42436328 0.25 ENSDART00000167324
early B cell factor 3a
chr14_+_6615564 0.24 ENSDART00000139292
si:dkeyp-44a8.2
chr15_-_17868870 0.24 ENSDART00000170950
activating transcription factor 5b
chr24_-_7697274 0.24 ENSDART00000186077
synaptotagmin Vb
chr17_-_45254585 0.23 ENSDART00000185507
ENSDART00000172080
tau tubulin kinase 2a
chr17_-_8268406 0.21 ENSDART00000149873
ENSDART00000064668
ENSDART00000148403
Abelson helper integration site 1
chr15_-_25099679 0.21 ENSDART00000154628
refilin B
chr18_-_26785861 0.21 ENSDART00000098361
neuromedin Ba
chr15_+_23550890 0.20 ENSDART00000009796
ENSDART00000152720
si:dkey-31m14.7
chr21_-_18648861 0.20 ENSDART00000112113
si:dkey-112m2.1
chr21_-_18262287 0.20 ENSDART00000176716
vav 2 guanine nucleotide exchange factor
chr21_-_43022048 0.19 ENSDART00000138329
dihydropyrimidinase-like 3
chr23_-_28025943 0.18 ENSDART00000181146
Sp5 transcription factor-like
chr1_-_55873178 0.18 ENSDART00000019936
protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
chr11_+_25693395 0.17 ENSDART00000110224
MON1 secretory trafficking family member Bb
chr15_-_17869115 0.17 ENSDART00000112838
activating transcription factor 5b
chr9_+_30112423 0.16 ENSDART00000112398
ENSDART00000013591
trk-fused gene
chr10_-_32920690 0.16 ENSDART00000136245
cut-like homeobox 1a
chr9_-_46701326 0.16 ENSDART00000159971
si:ch73-193i22.1
chr14_-_22152064 0.16 ENSDART00000115422
NudC domain containing 2
chr3_-_26787430 0.16 ENSDART00000087047
RAB40c, member RAS oncogene family
chr6_+_16468776 0.15 ENSDART00000109151
ENSDART00000114667
zgc:161969
chr15_-_25099233 0.15 ENSDART00000192617
refilin B
chr13_-_50002852 0.15 ENSDART00000099439
lysosomal trafficking regulator
chr20_+_34320635 0.15 ENSDART00000153207
influenza virus NS1A binding protein a
chr13_+_12761707 0.15 ENSDART00000015127
zgc:100846
chr5_+_42400777 0.14 ENSDART00000183114

chr5_+_34407763 0.14 ENSDART00000188849
ENSDART00000145127
laminin, gamma 3
chr23_-_24682244 0.14 ENSDART00000104035
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr10_-_5581487 0.14 ENSDART00000141943
spleen tyrosine kinase
chr20_+_2134816 0.13 ENSDART00000039249
l(3)mbt-like 3 (Drosophila)
chr10_+_29698467 0.13 ENSDART00000163402
discs, large homolog 2 (Drosophila)
chr22_-_27113332 0.13 ENSDART00000146951
ENSDART00000178855
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
chr11_+_7432533 0.13 ENSDART00000180977
adhesion G protein-coupled receptor L2a
chr17_-_39772999 0.13 ENSDART00000155727
Pim proto-oncogene, serine/threonine kinase, related 60
chr4_-_28158335 0.13 ENSDART00000134605
GRAM domain containing 4a
chr8_+_50953776 0.13 ENSDART00000013870
zgc:56596
chr12_+_17504559 0.12 ENSDART00000020628
cytohesin 3a
chr18_+_3243292 0.12 ENSDART00000166580
p21 protein (Cdc42/Rac)-activated kinase 1
chr22_+_17433968 0.12 ENSDART00000139523
RAB GTPase activating protein 1-like
chr7_+_29167744 0.11 ENSDART00000076345
solute carrier family 38, member 8b
chr25_+_5755314 0.11 ENSDART00000172088
ENSDART00000164208
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
chr11_-_37425407 0.11 ENSDART00000160911
ELKS/RAB6-interacting/CAST family member 2
chr6_-_3573716 0.11 ENSDART00000026693
diencephalon/mesencephalon homeobox 1b
chr17_-_14451718 0.10 ENSDART00000039438
jnk1/mapk8 associated membrane protein
chr12_+_28856151 0.10 ENSDART00000152969
nuclear factor, erythroid 2-like 1b
chr9_-_53537989 0.10 ENSDART00000114022
SLIT and NTRK-like family, member 5b
chr10_-_26744131 0.10 ENSDART00000020096
ENSDART00000162710
ENSDART00000179853
fibroblast growth factor 13b
chr15_+_25528290 0.10 ENSDART00000123143
nuclear protein, ataxia-telangiectasia locus
chr1_+_38142715 0.10 ENSDART00000079928
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr7_+_71764883 0.09 ENSDART00000166865
myosin, light chain 12, genome duplicate 1
chr22_+_39007533 0.09 ENSDART00000185958
ENSDART00000129848
family with sequence similarity 208, member Aa
chr15_+_8767650 0.09 ENSDART00000033871
adaptor-related protein complex 2, sigma 1 subunit
chr25_+_33002963 0.09 ENSDART00000187366

chr1_-_46706639 0.08 ENSDART00000074519
karyopherin alpha 3 (importin alpha 4)
chr3_-_12970418 0.08 ENSDART00000158747
platelet-derived growth factor alpha polypeptide b
chr24_+_25069609 0.08 ENSDART00000115165
APC membrane recruitment protein 2
chr13_-_49444636 0.08 ENSDART00000136991
interferon regulatory factor 2 binding protein 2a
chr13_+_15581270 0.08 ENSDART00000189880
ENSDART00000190067
ENSDART00000041293
MAP/microtubule affinity-regulating kinase 3a
chr23_-_18130264 0.07 ENSDART00000016976
nuclear casein kinase and cyclin-dependent kinase substrate 1b
chr17_-_14451405 0.07 ENSDART00000146786
jnk1/mapk8 associated membrane protein
chr20_-_28931901 0.07 ENSDART00000153082
ENSDART00000046042
sushi domain containing 6
chr8_+_35212233 0.07 ENSDART00000111021
si:dkeyp-14d3.1
chr20_+_22130284 0.06 ENSDART00000025575
clock circadian regulator a
chr5_-_32489796 0.06 ENSDART00000168870
G protein-coupled receptor 107
chr2_-_48153945 0.06 ENSDART00000146553
phosphofructokinase, platelet b
chr7_-_30367650 0.06 ENSDART00000075519
aldehyde dehydrogenase 1 family, member A2
chr5_+_48683447 0.05 ENSDART00000008043
adhesion G protein-coupled receptor V1
chr2_-_30135446 0.05 ENSDART00000141906
transient receptor potential cation channel, subfamily A, member 1a
chr5_-_68074592 0.05 ENSDART00000165052
ENSDART00000018792
sperm associated antigen 7
chr14_-_41388178 0.04 ENSDART00000124532
ENSDART00000125016
ENSDART00000169247
cleavage stimulation factor, 3' pre-RNA, subunit 2
chr7_+_38811800 0.04 ENSDART00000052322
zgc:110699
chr16_+_28727383 0.04 ENSDART00000149753
DC-STAMP domain containing 2
chr18_-_17145111 0.04 ENSDART00000090446
zinc finger CCCH-type containing 18
chr23_+_25135858 0.04 ENSDART00000103986
family with sequence similarity 3, member A
chr5_+_61361815 0.04 ENSDART00000009507
GATS protein-like 2
chr19_-_25113660 0.04 ENSDART00000035538
protein tyrosine phosphatase type IVA, member 3
chr13_-_25819825 0.04 ENSDART00000077612
v-rel avian reticuloendotheliosis viral oncogene homolog
chr17_-_12966907 0.04 ENSDART00000022874
proteasome subunit alpha 6a
chr3_+_29445473 0.04 ENSDART00000020381
GRB2-related adaptor protein 2a
chr21_-_44104600 0.03 ENSDART00000044599
organic anion transporter X
chr11_-_3535537 0.03 ENSDART00000165329
ENSDART00000009788
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 19 (DBP5 homolog, yeast)
chr17_+_30545895 0.03 ENSDART00000076739
NHS-like 1a
chr2_-_42071558 0.03 ENSDART00000142792
centrosome and spindle pole associated protein 1b
chr14_-_29859067 0.02 ENSDART00000136380
sorbin and SH3 domain containing 2b
chr19_+_9174166 0.02 ENSDART00000104637
ENSDART00000150968
si:ch211-81a5.8
chr5_-_18897482 0.02 ENSDART00000010101
ENSDART00000099434
acetoacetyl-CoA synthetase
chr11_-_29816429 0.02 ENSDART00000069132
cytochrome b-245, beta polypeptide (chronic granulomatous disease)
chr20_+_41664350 0.01 ENSDART00000186247
family with sequence similarity 184, member A
chr9_-_21825913 0.01 ENSDART00000101986
mitochondrial ribosomal protein L30
chr7_+_47243564 0.01 ENSDART00000098942
ENSDART00000162237
zinc finger protein 507
chr16_+_46410520 0.01 ENSDART00000131072
rapunzel 2
chr24_+_21346796 0.01 ENSDART00000126519
shisa family member 2b
chr14_-_46070802 0.00 ENSDART00000038670
E74-like factor 2a (ets domain transcription factor)
chr23_-_29553691 0.00 ENSDART00000053804
ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)
chr12_-_32013125 0.00 ENSDART00000153355
glutamate receptor, ionotropic, N-methyl D-aspartate 2Cb
chr16_-_52646789 0.00 ENSDART00000035761
ubiquitin protein ligase E3 component n-recognin 5
chr13_+_18507592 0.00 ENSDART00000142622
si:ch211-198a12.6
chr5_+_45138934 0.00 ENSDART00000041412
ENSDART00000136002
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

Network of associatons between targets according to the STRING database.

First level regulatory network of drgx_arxb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:1900620 acetylcholine biosynthetic process(GO:0008292) acetate ester biosynthetic process(GO:1900620)
0.2 0.9 GO:0051703 mammillary body development(GO:0021767) social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
0.1 0.4 GO:1900157 negative regulation of chondrocyte differentiation(GO:0032331) negative regulation of cartilage development(GO:0061037) negative regulation of chondrocyte development(GO:0061182) regulation of bone mineralization involved in bone maturation(GO:1900157) negative regulation of bone mineralization involved in bone maturation(GO:1900158) negative regulation of bone development(GO:1903011)
0.1 0.4 GO:0099548 trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by nitric oxide(GO:0099548)
0.1 0.4 GO:0033119 negative regulation of RNA splicing(GO:0033119) negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.1 0.9 GO:0034605 cellular response to heat(GO:0034605)
0.1 0.5 GO:0021877 forebrain neuron fate commitment(GO:0021877)
0.1 1.0 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 0.4 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
0.0 0.3 GO:0048260 positive regulation of receptor-mediated endocytosis(GO:0048260)
0.0 0.1 GO:0045579 positive regulation of B cell differentiation(GO:0045579)
0.0 0.3 GO:1901673 regulation of mitotic spindle assembly(GO:1901673)
0.0 0.1 GO:0034163 regulation of toll-like receptor 9 signaling pathway(GO:0034163) negative regulation of toll-like receptor 9 signaling pathway(GO:0034164)
0.0 0.5 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 0.3 GO:0035677 posterior lateral line neuromast hair cell development(GO:0035677)
0.0 0.3 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.0 0.5 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.1 GO:0036268 swimming(GO:0036268)
0.0 0.1 GO:0003232 bulbus arteriosus development(GO:0003232)
0.0 0.2 GO:0044458 motile cilium assembly(GO:0044458)
0.0 0.4 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.1 GO:0097264 self proteolysis(GO:0097264)
0.0 0.2 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 0.7 GO:0072114 pronephros morphogenesis(GO:0072114)
0.0 0.2 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 1.3 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.2 GO:0046887 positive regulation of hormone secretion(GO:0046887)
0.0 0.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.4 GO:0050708 regulation of protein secretion(GO:0050708)
0.0 0.3 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.1 GO:0050955 thermoception(GO:0050955) detection of temperature stimulus involved in thermoception(GO:0050960) detection of temperature stimulus involved in sensory perception(GO:0050961)
0.0 0.1 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0 0.2 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.1 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.1 GO:0046958 learning(GO:0007612) nonassociative learning(GO:0046958) habituation(GO:0046959)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0098842 postsynaptic early endosome(GO:0098842)
0.1 0.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.3 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.0 0.2 GO:0031045 dense core granule(GO:0031045)
0.0 0.1 GO:0071818 BAT3 complex(GO:0071818)
0.0 0.1 GO:0060171 stereocilium membrane(GO:0060171)
0.0 0.1 GO:1990513 CLOCK-BMAL transcription complex(GO:1990513)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0031005 filamin binding(GO:0031005)
0.1 1.3 GO:0005080 protein kinase C binding(GO:0005080)
0.1 0.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.6 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 0.2 GO:0031705 bombesin receptor binding(GO:0031705)
0.0 0.2 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.2 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.3 GO:0000700 mismatch base pair DNA N-glycosylase activity(GO:0000700) pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
0.0 0.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.4 GO:0045159 myosin II binding(GO:0045159)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.4 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.3 GO:0030552 cAMP binding(GO:0030552)
0.0 0.2 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.1 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.7 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.5 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.5 GO:0008374 O-acyltransferase activity(GO:0008374)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.3 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.2 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.1 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.2 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling