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PRJNA207719: Tissue specific transcriptome profiling

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Results for gli1+gli2b

Z-value: 1.26

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Transcription factors associated with gli1+gli2b

Gene Symbol Gene ID Gene Info
gli2b
ENSDARG00000020884 GLI family zinc finger 2b
gli1
ENSDARG00000101244 GLI family zinc finger 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
gli1dr11_v1_chr6_-_59505589_59505589-0.375.5e-01Click!
gli2bdr11_v1_chr11_+_43661735_43661735-0.286.5e-01Click!

Activity profile of gli1+gli2b motif

Sorted Z-values of gli1+gli2b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr23_+_20422661 1.27 ENSDART00000144047
ENSDART00000104336
tnnc2
troponin C type 2 (fast)
chr7_+_29952719 1.06 ENSDART00000173737
tpma
alpha-tropomyosin
chr7_+_29952169 1.05 ENSDART00000173540
ENSDART00000173940
ENSDART00000173906
ENSDART00000173772
ENSDART00000173506
ENSDART00000039657
tpma
alpha-tropomyosin
chr12_-_464007 1.01 ENSDART00000106669
dhrs7cb
dehydrogenase/reductase (SDR family) member 7Cb
chr18_+_5547185 1.00 ENSDART00000193977
nnt2
nicotinamide nucleotide transhydrogenase 2
chr7_+_29951997 0.99 ENSDART00000173453
tpma
alpha-tropomyosin
chr14_+_15543331 0.73 ENSDART00000167025
si:dkey-203a12.7
si:dkey-203a12.7
chr10_+_33171501 0.72 ENSDART00000159666
myl10
myosin, light chain 10, regulatory
chr14_+_15257658 0.70 ENSDART00000161625
ENSDART00000193577
si:dkey-77g12.4
si:dkey-203a12.5
si:dkey-77g12.4
si:dkey-203a12.5
chr14_+_15430991 0.61 ENSDART00000158221
si:dkey-203a12.5
si:dkey-203a12.5
chr4_-_17741513 0.59 ENSDART00000141680
mybpc1
myosin binding protein C, slow type
chr20_-_54377933 0.55 ENSDART00000182664
entpd5b
ectonucleoside triphosphate diphosphohydrolase 5b
chr14_+_15495088 0.54 ENSDART00000165765
ENSDART00000188577
si:dkey-203a12.6
si:dkey-203a12.6
chr19_+_9004256 0.53 ENSDART00000186401
ENSDART00000091443
si:ch211-81a5.1
si:ch211-81a5.1
chr14_+_15231097 0.52 ENSDART00000172430
si:dkey-203a12.3
si:dkey-203a12.3
chr14_+_15597049 0.51 ENSDART00000159732
si:dkey-203a12.8
si:dkey-203a12.8
chr14_+_15331486 0.49 ENSDART00000172077
ENSDART00000183370
ENSDART00000182467
SPINK2
si:dkey-203a12.5
si:dkey-203a12.4
si:dkey-203a12.5
chr25_+_30298377 0.49 ENSDART00000153622
C11orf96
chromosome 11 open reading frame 96
chr1_-_470812 0.48 ENSDART00000192527
zgc:92518
zgc:92518
chr12_+_27462225 0.46 ENSDART00000105661
meox1
mesenchyme homeobox 1
chr10_+_43188678 0.44 ENSDART00000012522
vcanb
versican b
chr16_-_13595027 0.41 ENSDART00000060004
ntd5
ntl-dependent gene 5
chr20_-_53996193 0.41 ENSDART00000004756
hsp90aa1.1
heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1
chr13_-_865193 0.36 ENSDART00000187053
AL929536.7

chr8_+_28469054 0.34 ENSDART00000062716
slc52a3
solute carrier family 52 (riboflavin transporter), member 3
chr16_-_30885838 0.34 ENSDART00000131356
dennd3b
DENN/MADD domain containing 3b
chr14_-_29859067 0.33 ENSDART00000136380
sorbs2b
sorbin and SH3 domain containing 2b
chr20_+_27194833 0.32 ENSDART00000150072
si:dkey-85n7.8
si:dkey-85n7.8
chr14_-_15171435 0.31 ENSDART00000159148
ENSDART00000166622
si:dkey-77g12.1
si:dkey-77g12.1
chr6_-_3982783 0.30 ENSDART00000171944
slc25a12
solute carrier family 25 (aspartate/glutamate carrier), member 12
chr22_-_3344613 0.29 ENSDART00000165600
tbxa2r
thromboxane A2 receptor
chr8_-_40327397 0.28 ENSDART00000074125
aplnra
apelin receptor a
chr16_-_43041324 0.28 ENSDART00000155445
ENSDART00000156836
ENSDART00000154945
si:dkey-7j14.6
si:dkey-7j14.6
chr21_-_30415524 0.27 ENSDART00000101036
grpel2
GrpE-like 2, mitochondrial
chr7_+_31871830 0.26 ENSDART00000139899
mybpc3
myosin binding protein C, cardiac
chrM_+_9735 0.24 ENSDART00000093613
mt-co3
cytochrome c oxidase III, mitochondrial
chr14_+_15155684 0.22 ENSDART00000167966
zgc:158852
zgc:158852
chr10_-_24391716 0.22 ENSDART00000141332
ENSDART00000100772
slc43a2b
solute carrier family 43 (amino acid system L transporter), member 2b
chr13_+_228045 0.22 ENSDART00000161091
zgc:64201
zgc:64201
chr12_+_35650321 0.22 ENSDART00000190446
BX255898.1

chr4_+_10721795 0.21 ENSDART00000136000
ENSDART00000067253
stab2
stabilin 2
chr15_-_34056733 0.20 ENSDART00000170130
ENSDART00000188272
VWDE
si:dkey-30e9.7
chr7_-_27037990 0.20 ENSDART00000173561
nucb2a
nucleobindin 2a
chr22_-_22147375 0.18 ENSDART00000149304
cdc34a
cell division cycle 34 homolog (S. cerevisiae) a
chr10_-_24391030 0.17 ENSDART00000180013
ENSDART00000177914
slc43a2b
solute carrier family 43 (amino acid system L transporter), member 2b
chr13_-_17723417 0.16 ENSDART00000183834
vdac2
voltage-dependent anion channel 2
chr7_+_4162994 0.16 ENSDART00000172800
si:ch211-63p21.1
si:ch211-63p21.1
chr11_+_24314148 0.16 ENSDART00000171491
rem1
RAS (RAD and GEM)-like GTP-binding 1
chr8_-_14121634 0.16 ENSDART00000184946
bgna
biglycan a
chr10_-_39154594 0.16 ENSDART00000148825
slc37a4b
solute carrier family 37 (glucose-6-phosphate transporter), member 4b
chr4_-_72101234 0.16 ENSDART00000167048
slco1f1
solute carrier organic anion transporter family, member 1F1
chr10_+_15224660 0.16 ENSDART00000137932
sh3bp2
SH3-domain binding protein 2
chr12_-_26415499 0.15 ENSDART00000185779
synpo2lb
synaptopodin 2-like b
chr5_+_10046643 0.14 ENSDART00000137543
ENSDART00000186917
gstt2
glutathione S-transferase theta 2
chr2_-_44199722 0.14 ENSDART00000140633
ENSDART00000145728
sdhc
succinate dehydrogenase complex, subunit C, integral membrane protein
chr24_-_6158933 0.13 ENSDART00000021609
gad2
glutamate decarboxylase 2
chr13_-_9598320 0.13 ENSDART00000184613
cpxm1a
carboxypeptidase X (M14 family), member 1a
chr18_+_25653599 0.13 ENSDART00000007856
fkbp16
FK506 binding protein 16
chr11_+_30306606 0.13 ENSDART00000128276
ENSDART00000190222
ugt1b4
UDP glucuronosyltransferase 1 family, polypeptide B4
chr21_-_17037907 0.13 ENSDART00000101263
ube2g1b
ubiquitin-conjugating enzyme E2G 1b (UBC7 homolog, yeast)
chr11_+_44300548 0.13 ENSDART00000191626
CABZ01100304.1

chr15_-_43287515 0.12 ENSDART00000155103
prss16
protease, serine, 16 (thymus)
chr3_-_9488350 0.12 ENSDART00000186707
FO904885.2

chr16_+_13822137 0.11 ENSDART00000163251
flcn
folliculin
chr5_+_36439405 0.11 ENSDART00000102973
eda
ectodysplasin A
chr1_+_59090743 0.11 ENSDART00000100199
mfap4
microfibril associated protein 4
chr6_+_27090800 0.10 ENSDART00000121558
atg4b
autophagy related 4B, cysteine peptidase
chr7_+_10701770 0.10 ENSDART00000167323
arnt2
aryl-hydrocarbon receptor nuclear translocator 2
chr4_-_77506362 0.10 ENSDART00000174387
ENSDART00000181181
CABZ01087415.1

chr15_+_25489406 0.10 ENSDART00000162482
zgc:152863
zgc:152863
chr12_+_34273240 0.10 ENSDART00000037904
socs3b
suppressor of cytokine signaling 3b
chr6_-_30859656 0.09 ENSDART00000156235
pde4ba
phosphodiesterase 4B, cAMP-specific a
chr15_-_38129845 0.09 ENSDART00000057095
si:dkey-24p1.1
si:dkey-24p1.1
chr25_+_7461624 0.08 ENSDART00000170569
syt12
synaptotagmin XII
chr6_-_436658 0.07 ENSDART00000191515
grap2b
GRB2-related adaptor protein 2b
chr7_+_10701938 0.07 ENSDART00000158162
arnt2
aryl-hydrocarbon receptor nuclear translocator 2
chr22_+_26665422 0.07 ENSDART00000164994
adcy9
adenylate cyclase 9
chr1_+_57235896 0.07 ENSDART00000152621
si:dkey-27j5.7
si:dkey-27j5.7
chr4_-_11077872 0.07 ENSDART00000150566
BX784029.4

chr12_-_4756478 0.07 ENSDART00000152181
mapta
microtubule-associated protein tau a
chr14_-_45702721 0.06 ENSDART00000165727
si:dkey-226n24.1
si:dkey-226n24.1
chr23_+_26009266 0.06 ENSDART00000054025
si:dkey-78k11.9
si:dkey-78k11.9
chr5_+_40224938 0.06 ENSDART00000142897
si:dkey-193c22.2
si:dkey-193c22.2
chr7_+_18075504 0.06 ENSDART00000173689
si:ch73-40a2.1
si:ch73-40a2.1
chr5_+_36513605 0.06 ENSDART00000013590
wnt11
wingless-type MMTV integration site family, member 11
chr16_-_12784373 0.06 ENSDART00000080396
foxj2
forkhead box J2
chr20_+_51730658 0.05 ENSDART00000010271
aida
axin interactor, dorsalization associated
chr4_-_2219705 0.05 ENSDART00000131046
si:ch73-278m9.1
si:ch73-278m9.1
chr21_-_8370500 0.05 ENSDART00000055328
nek6
NIMA-related kinase 6
chr20_+_35484070 0.05 ENSDART00000026234
ENSDART00000141675
mep1a.2
meprin A, alpha (PABA peptide hydrolase), tandem duplicate 2
chr18_+_14529005 0.05 ENSDART00000186379
kcng4a
potassium voltage-gated channel, subfamily G, member 4a
chr4_+_38170708 0.05 ENSDART00000168900
znf1071
zinc finger protein 1071
chr17_-_17447899 0.05 ENSDART00000156928
ENSDART00000109034
nrxn3a
neurexin 3a
chr5_-_17876709 0.04 ENSDART00000141978
si:dkey-112e17.1
si:dkey-112e17.1
chr17_-_722218 0.04 ENSDART00000160385
SLC25A29
solute carrier family 25 member 29
chr25_-_34740627 0.04 ENSDART00000137665
frs2b
fibroblast growth factor receptor substrate 2b
chr13_-_39947335 0.04 ENSDART00000056996
sfrp5
secreted frizzled-related protein 5
chr6_+_28796773 0.04 ENSDART00000168237
ENSDART00000163541
tp63
tumor protein p63
chr18_-_45617146 0.04 ENSDART00000146543
wt1b
wilms tumor 1b
chr4_-_5856200 0.03 ENSDART00000121936
slc5a8
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
chr22_+_31207799 0.03 ENSDART00000133267
grip2b
glutamate receptor interacting protein 2b
chr5_+_52844681 0.03 ENSDART00000162459
ENSDART00000184914
scarb2a
scavenger receptor class B, member 2a
chr21_-_41873065 0.03 ENSDART00000014538
endou2
endonuclease, polyU-specific 2
chr18_-_39636348 0.03 ENSDART00000129828
cyp19a1a
cytochrome P450, family 19, subfamily A, polypeptide 1a
chr2_+_54086436 0.03 ENSDART00000174581
CU179656.1

chr15_+_7992906 0.03 ENSDART00000090790
cadm2b
cell adhesion molecule 2b
chr25_+_32473433 0.03 ENSDART00000152326
sqor
sulfide quinone oxidoreductase
chr17_-_50331351 0.03 ENSDART00000149294
otofb
otoferlin b
chr8_+_1065458 0.03 ENSDART00000081432
sprb
sepiapterin reductase b
chr18_-_40753583 0.03 ENSDART00000026767
akt2
v-akt murine thymoma viral oncogene homolog 2
chr2_+_58877162 0.03 ENSDART00000122174
CABZ01085658.1

chr5_-_43959972 0.03 ENSDART00000180517
si:ch211-204c21.1
si:ch211-204c21.1
chr11_+_14295011 0.03 ENSDART00000060226
si:ch211-262i1.4
si:ch211-262i1.4
chr4_+_58016732 0.03 ENSDART00000165777
CT027609.1

chr10_+_42691210 0.03 ENSDART00000193813
rhobtb2b
Rho-related BTB domain containing 2b
chr15_+_32411660 0.02 ENSDART00000113443
si:dkey-285b23.4
si:dkey-285b23.4
chr19_-_6988837 0.02 ENSDART00000145741
ENSDART00000167640
znf384l
zinc finger protein 384 like
chr21_-_21465111 0.02 ENSDART00000141487
nectin3b
nectin cell adhesion molecule 3b
chr3_-_33941319 0.02 ENSDART00000026090
ENSDART00000111878
gtf2f1
general transcription factor IIF, polypeptide 1
chr2_+_30147504 0.02 ENSDART00000190947
kcnb2
potassium voltage-gated channel, Shab-related subfamily, member 2
chr13_-_1423008 0.02 ENSDART00000110828
znf451
zinc finger protein 451
chr10_-_44411032 0.02 ENSDART00000111509
CABZ01072096.1

chr21_-_41873584 0.02 ENSDART00000188089
endou2
endonuclease, polyU-specific 2
chr8_-_43847138 0.01 ENSDART00000148358
adgrd1
adhesion G protein-coupled receptor D1
chr9_+_17862858 0.01 ENSDART00000166566
dgkh
diacylglycerol kinase, eta
chr10_+_5645887 0.01 ENSDART00000171426
pdzph1
PDZ and pleckstrin homology domains 1
chr6_-_11768198 0.01 ENSDART00000183463
march7
membrane-associated ring finger (C3HC4) 7
chr4_+_63253425 0.01 ENSDART00000193510
si:ch211-258f1.3
si:ch211-258f1.3
chr25_+_245438 0.01 ENSDART00000004689
zgc:92481
zgc:92481
chr6_-_10693111 0.01 ENSDART00000187206
ENSDART00000192319
dnah9l
dynein, axonemal, heavy polypeptide 9 like
chr4_+_5132951 0.01 ENSDART00000103279
ccnd2b
cyclin D2, b
chr25_+_32474031 0.01 ENSDART00000152124
sqor
sulfide quinone oxidoreductase
chr5_-_22615087 0.01 ENSDART00000146035
zgc:113208
zgc:113208
chr19_-_9776075 0.01 ENSDART00000140332
si:dkey-14o18.1
si:dkey-14o18.1
chr1_+_59090583 0.01 ENSDART00000150658
mfap4
microfibril associated protein 4
chr4_+_28997595 0.01 ENSDART00000133357
si:dkey-13e3.1
si:dkey-13e3.1
chr21_+_10739846 0.00 ENSDART00000084011
cplx4a
complexin 4a
chr5_-_25123807 0.00 ENSDART00000183171
abca2
ATP-binding cassette, sub-family A (ABC1), member 2
chr1_-_31505144 0.00 ENSDART00000087115
rims1b
regulating synaptic membrane exocytosis 1b
chr23_+_28582865 0.00 ENSDART00000020296
l1cama
L1 cell adhesion molecule, paralog a

Network of associatons between targets according to the STRING database.

First level regulatory network of gli1+gli2b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0006740 NADPH regeneration(GO:0006740)
0.1 0.4 GO:1903428 regulation of nitric oxide biosynthetic process(GO:0045428) positive regulation of nitric oxide biosynthetic process(GO:0045429) positive regulation of reactive oxygen species biosynthetic process(GO:1903428) positive regulation of nitric oxide metabolic process(GO:1904407)
0.1 0.3 GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587) positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903589)
0.1 1.3 GO:0014823 response to activity(GO:0014823)
0.1 0.3 GO:0032218 riboflavin transport(GO:0032218)
0.1 0.2 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.1 0.3 GO:0003210 cardiac atrium formation(GO:0003210)
0.0 0.5 GO:0061056 sclerotome development(GO:0061056)
0.0 0.1 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0 0.5 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.0 0.2 GO:1901842 regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.0 0.3 GO:0015810 acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.0 3.0 GO:0061515 myeloid cell development(GO:0061515)
0.0 0.3 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 0.1 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.0 0.3 GO:0045777 positive regulation of blood pressure(GO:0045777)
0.0 0.2 GO:0032096 negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
0.0 0.3 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 0.2 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.1 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0 0.2 GO:0072576 liver morphogenesis(GO:0072576)
0.0 0.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.0 GO:0070221 sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)
0.0 0.1 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.0 GO:0030237 female sex determination(GO:0030237) male sex determination(GO:0030238)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.6 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 1.3 GO:0005861 troponin complex(GO:0005861)
0.0 0.1 GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 3.1 GO:0005884 actin filament(GO:0005884)
0.0 0.4 GO:0043209 myelin sheath(GO:0043209)
0.0 0.2 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0016652 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.1 0.3 GO:0032217 riboflavin transporter activity(GO:0032217)
0.1 0.3 GO:0060182 apelin receptor activity(GO:0060182)
0.0 0.3 GO:0004960 thromboxane receptor activity(GO:0004960)
0.0 0.1 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.0 1.3 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.2 GO:0015288 porin activity(GO:0015288)
0.0 0.5 GO:0004382 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.0 0.3 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.3 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.3 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 3.1 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.2 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.0 0.6 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.1 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.0 GO:0070224 sulfide:quinone oxidoreductase activity(GO:0070224)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 0.3 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.2 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.3 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis